PRELP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.29842700
2collagen fibril organization (GO:0030199)5.12020062
3cell migration involved in heart development (GO:0060973)5.10964398
4low-density lipoprotein particle clearance (GO:0034383)4.43762086
5positive regulation of fatty acid oxidation (GO:0046321)4.39247658
6regulation of sequestering of triglyceride (GO:0010889)4.30216029
7positive regulation of fatty acid beta-oxidation (GO:0032000)4.23798010
8* keratan sulfate catabolic process (GO:0042340)4.17075003
9cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.14496271
10retina vasculature morphogenesis in camera-type eye (GO:0061299)4.09528283
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.07222717
12adhesion of symbiont to host cell (GO:0044650)4.03215338
13virion attachment to host cell (GO:0019062)4.03215338
14endothelial cell morphogenesis (GO:0001886)3.95289924
15positive regulation of extracellular matrix organization (GO:1903055)3.68877073
16epoxygenase P450 pathway (GO:0019373)3.53455826
17collagen metabolic process (GO:0032963)3.51196744
18chondrocyte development (GO:0002063)3.46648537
19collagen catabolic process (GO:0030574)3.45077931
20multicellular organismal macromolecule metabolic process (GO:0044259)3.42577841
21brown fat cell differentiation (GO:0050873)3.41868136
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.41502281
23smooth muscle tissue development (GO:0048745)3.39564513
24regulation of fatty acid oxidation (GO:0046320)3.38501025
25adhesion of symbiont to host (GO:0044406)3.34834322
26multicellular organismal metabolic process (GO:0044236)3.32623493
27triglyceride catabolic process (GO:0019433)3.29697862
28fatty acid transmembrane transport (GO:1902001)3.27766981
29complement activation, alternative pathway (GO:0006957)3.26588102
30regulation of fatty acid beta-oxidation (GO:0031998)3.25970437
31multicellular organismal catabolic process (GO:0044243)3.23908638
32blood vessel maturation (GO:0001955)3.23447895
33atrioventricular valve morphogenesis (GO:0003181)3.23444776
34endocrine hormone secretion (GO:0060986)3.20485412
35positive regulation of fatty acid metabolic process (GO:0045923)3.19186567
36basement membrane organization (GO:0071711)3.14636104
37metanephric mesenchyme development (GO:0072075)3.14023121
38cell proliferation involved in metanephros development (GO:0072203)3.10902772
39biotin metabolic process (GO:0006768)3.10600864
40regulation of plasminogen activation (GO:0010755)3.09479355
41regulation of integrin-mediated signaling pathway (GO:2001044)3.08156037
42apoptotic cell clearance (GO:0043277)3.07448358
43extracellular matrix assembly (GO:0085029)3.06707144
44negative regulation of protein autophosphorylation (GO:0031953)3.06395235
45endothelium development (GO:0003158)3.05492203
46positive regulation of glycogen biosynthetic process (GO:0045725)3.04943515
47white fat cell differentiation (GO:0050872)3.04790895
48lipid particle organization (GO:0034389)3.04564102
49fatty acid beta-oxidation (GO:0006635)3.04125184
50neutral lipid catabolic process (GO:0046461)3.03920647
51acylglycerol catabolic process (GO:0046464)3.03920647
52peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03828642
53cardiac myofibril assembly (GO:0055003)3.03683651
54extracellular fibril organization (GO:0043206)3.03439276
55negative regulation of complement activation (GO:0045916)3.01778639
56extracellular matrix disassembly (GO:0022617)3.00795071
57dermatan sulfate biosynthetic process (GO:0030208)3.00436603
58growth hormone secretion (GO:0030252)3.00253445
59endodermal cell differentiation (GO:0035987)2.99611859
60positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.99564026
61glomerular filtration (GO:0003094)2.98075817
62vitamin A metabolic process (GO:0006776)2.96775092
63alpha-linolenic acid metabolic process (GO:0036109)2.96246778
64positive regulation of vasculogenesis (GO:2001214)2.94801953
65carnitine shuttle (GO:0006853)2.94592994
66regulation of vasculogenesis (GO:2001212)2.92319750
67chondroitin sulfate catabolic process (GO:0030207)2.91665794
68vascular endothelial growth factor signaling pathway (GO:0038084)2.91017865
69regulation of complement activation (GO:0030449)2.89744353
70valine metabolic process (GO:0006573)2.89607136
71negative regulation of platelet activation (GO:0010544)2.89162233
72regulation of cholesterol storage (GO:0010885)2.88361774
73negative regulation of cartilage development (GO:0061037)2.88073151
74kidney mesenchyme development (GO:0072074)2.87829237
75cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87283927
76cGMP biosynthetic process (GO:0006182)2.86453059
77ovulation from ovarian follicle (GO:0001542)2.82593523
78type B pancreatic cell proliferation (GO:0044342)2.81581771
79glomerular basement membrane development (GO:0032836)2.76739559
80positive regulation of lipid catabolic process (GO:0050996)2.76413327
81dermatan sulfate metabolic process (GO:0030205)2.76107398
82regulation of protein activation cascade (GO:2000257)2.76002610
83cGMP-mediated signaling (GO:0019934)2.75003614
84striated muscle hypertrophy (GO:0014897)2.74509728
85negative regulation of protein activation cascade (GO:2000258)2.73036918
86opsonization (GO:0008228)2.72476087
87complement activation, classical pathway (GO:0006958)2.72363748
88bone trabecula formation (GO:0060346)2.72057814
89positive regulation of endothelial cell apoptotic process (GO:2000353)2.71806387
90barbed-end actin filament capping (GO:0051016)2.71484689
91renal filtration (GO:0097205)2.68757712
92fatty acid oxidation (GO:0019395)2.68712328
93cell proliferation involved in kidney development (GO:0072111)2.68637779
94muscle hypertrophy (GO:0014896)2.68631731
95positive regulation of cellular response to insulin stimulus (GO:1900078)2.67745203
96positive regulation of glycogen metabolic process (GO:0070875)2.65951978
97lipid oxidation (GO:0034440)2.65731558
98phagocytosis, recognition (GO:0006910)2.65579204
99iron ion import (GO:0097286)2.64691770
100positive regulation of chondrocyte differentiation (GO:0032332)2.64292501
101fibril organization (GO:0097435)2.64210967
102negative regulation of chondrocyte differentiation (GO:0032331)2.64070363
103lymph vessel development (GO:0001945)2.62774803
104positive regulation of p38MAPK cascade (GO:1900745)2.61814232
105homocysteine metabolic process (GO:0050667)2.61797981
106chondroitin sulfate biosynthetic process (GO:0030206)2.61750405
107skin morphogenesis (GO:0043589)2.61589874
108sequestering of extracellular ligand from receptor (GO:0035581)2.61422271
109negative regulation of endothelial cell proliferation (GO:0001937)2.60579041
110cell aggregation (GO:0098743)2.60036219
111cartilage condensation (GO:0001502)2.60036219
112extracellular matrix organization (GO:0030198)2.59737700
113regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59230413
114mesenchyme morphogenesis (GO:0072132)2.58892997
115extracellular structure organization (GO:0043062)2.58864103
116fatty acid catabolic process (GO:0009062)2.57846349
117cardiac muscle hypertrophy (GO:0003300)2.57284836
118myelination in peripheral nervous system (GO:0022011)2.56180211
119peripheral nervous system axon ensheathment (GO:0032292)2.56180211
120cardiac muscle hypertrophy in response to stress (GO:0014898)2.56086073
121muscle hypertrophy in response to stress (GO:0003299)2.56086073
122cardiac muscle adaptation (GO:0014887)2.56086073
123fibroblast migration (GO:0010761)2.54795057
124positive regulation of cartilage development (GO:0061036)2.54217459
125negative regulation of smooth muscle cell migration (GO:0014912)2.53383745
126negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53307492
127myofibril assembly (GO:0030239)2.53214921
128negative regulation of cardiac muscle tissue growth (GO:0055022)2.52578378
129negative regulation of heart growth (GO:0061117)2.52578378
130response to misfolded protein (GO:0051788)2.51260771
131lymphangiogenesis (GO:0001946)2.50737128
132complement activation (GO:0006956)2.50676833
133endocardial cushion morphogenesis (GO:0003203)2.50294494
134* sulfur compound catabolic process (GO:0044273)2.50033470
135regulation of triglyceride catabolic process (GO:0010896)2.49975238
136venous blood vessel morphogenesis (GO:0048845)2.49915771
137chondrocyte proliferation (GO:0035988)2.48376844
138neuron projection extension involved in neuron projection guidance (GO:1902284)2.47432161
139axon extension involved in axon guidance (GO:0048846)2.47432161
140vasculature development (GO:0001944)2.47108434
141positive regulation of fat cell differentiation (GO:0045600)2.45986906
142metanephric nephron tubule development (GO:0072234)2.45363645
143metanephric tubule development (GO:0072170)2.45363645
144peptidyl-glutamic acid carboxylation (GO:0017187)2.45223816
145protein carboxylation (GO:0018214)2.45223816
146triglyceride homeostasis (GO:0070328)2.45214146
147acylglycerol homeostasis (GO:0055090)2.45214146
148negative regulation of gluconeogenesis (GO:0045721)2.44837331
149glial cell proliferation (GO:0014009)2.44702935
150nephron epithelium development (GO:0072009)2.43949406
151protein trimerization (GO:0070206)2.40894590
152negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.40344265
153negative regulation of BMP signaling pathway (GO:0030514)2.38580760
154positive regulation of vascular permeability (GO:0043117)2.37069755
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.37067237
156cGMP metabolic process (GO:0046068)2.36917256
157heart valve morphogenesis (GO:0003179)2.35560621
158regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.34803389
159metanephric nephron epithelium development (GO:0072243)2.33930570
160regulation of endothelial cell differentiation (GO:0045601)2.31744945
161negative regulation of protein localization to cell surface (GO:2000009)2.30665816
162cell volume homeostasis (GO:0006884)2.28843503
163* keratan sulfate biosynthetic process (GO:0018146)2.28575787
164negative regulation of vascular permeability (GO:0043116)2.28119637
165nephron tubule development (GO:0072080)2.27081363
166cyclic purine nucleotide metabolic process (GO:0052652)2.26339483
167regulation of vascular permeability (GO:0043114)2.25293864
168negative regulation of leukocyte chemotaxis (GO:0002689)2.23628996
169cell differentiation involved in metanephros development (GO:0072202)2.21746789
170positive regulation of receptor recycling (GO:0001921)2.21726903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.39515004
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.15692865
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.53596509
4CLOCK_20551151_ChIP-Seq_293T_Human3.49373871
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.23604307
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.17227183
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.00957995
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.80604367
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.66530718
10EZH2_22144423_ChIP-Seq_EOC_Human2.45649095
11* LXR_22158963_ChIP-Seq_LIVER_Mouse2.44971969
12* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.43230927
13GATA1_22025678_ChIP-Seq_K562_Human2.36489785
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.36114965
15* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12919086
16* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.10452590
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.07682606
18CJUN_26792858_Chip-Seq_BT549_Human2.04137303
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.04131159
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03919411
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.90279379
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82139303
23AR_21572438_ChIP-Seq_LNCaP_Human1.76105650
24GBX2_23144817_ChIP-Seq_PC3_Human1.74204362
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70113708
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63725723
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.63574261
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.61383554
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56800747
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50418252
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50282912
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50282912
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50126695
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.49383631
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.49383631
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47905416
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47723374
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.46721973
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.44060720
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.43875959
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.41039752
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40671338
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37931296
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37808678
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36850949
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36075438
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36075438
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35944128
49PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.32516341
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30196929
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30080397
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28985552
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27449395
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27325293
55* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27283610
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26907590
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25126123
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24435407
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.23310520
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22465833
61VDR_22108803_ChIP-Seq_LS180_Human1.21340739
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20722745
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.20561942
64* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.19896578
65SOX2_20726797_ChIP-Seq_SW620_Human1.18204346
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18007219
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17878680
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17353398
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16696964
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16231545
71TP53_18474530_ChIP-ChIP_U2OS_Human1.13094275
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12108246
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11759721
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10389543
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10169394
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08599549
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07307672
78BRD4_25478319_ChIP-Seq_HGPS_Human1.06697338
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06197194
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.05483223
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05209628
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.04888731
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03974131
84* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03674371
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.01998290
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01879352
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01549589
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01331129
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01152303
90RXR_22108803_ChIP-Seq_LS180_Human1.01058027
91SA1_22415368_ChIP-Seq_MEFs_Mouse0.99768739
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98675219
93SMAD4_21799915_ChIP-Seq_A2780_Human0.98391844
94BCAT_22108803_ChIP-Seq_LS180_Human0.98185118
95JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96689217
96CBX2_27304074_Chip-Seq_ESCs_Mouse0.95720931
97ZNF263_19887448_ChIP-Seq_K562_Human0.94899557
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94565714
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.94145553
100TP53_16413492_ChIP-PET_HCT116_Human0.93942015
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.92820396
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92592860
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92237984
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91925539
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91013500
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.89932966
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89563703
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89143541
109EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88739250
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.87557002
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85577864
112VDR_24787735_ChIP-Seq_THP-1_Human0.85564582
113AHR_22903824_ChIP-Seq_MCF-7_Human0.83832365
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83518889
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82721310
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82589437
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82498595
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82159091
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.81957884
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81819969
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81151718
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.78684129
123DROSHA_22980978_ChIP-Seq_HELA_Human0.78583592
124KDM2B_26808549_Chip-Seq_K562_Human0.78427184
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78388955
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77900478
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77850028
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77832988
129* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77755025
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77681220
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77681220
132KDM2B_26808549_Chip-Seq_REH_Human0.77610594
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.77510919
134CTCF_27219007_Chip-Seq_Bcells_Human0.77436983
135RACK7_27058665_Chip-Seq_MCF-7_Human0.77183350
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77033172
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76736846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.35005354
2MP0005275_abnormal_skin_tensile5.39866364
3MP0005503_abnormal_tendon_morphology5.26578619
4MP0003011_delayed_dark_adaptation3.65055757
5MP0003705_abnormal_hypodermis_morpholog3.64733065
6MP0005670_abnormal_white_adipose3.48630691
7MP0001958_emphysema3.17584881
8MP0003279_aneurysm2.90137075
9MP0004272_abnormal_basement_membrane2.74070617
10MP0005666_abnormal_adipose_tissue2.35685582
11MP0004130_abnormal_muscle_cell2.20913910
12MP0010368_abnormal_lymphatic_system2.10239024
13MP0009384_cardiac_valve_regurgitation2.08018076
14MP0002837_dystrophic_cardiac_calcinosis2.05918779
15MP0000751_myopathy2.04539966
16MP0002108_abnormal_muscle_morphology2.00248355
17MP0000013_abnormal_adipose_tissue1.92935031
18MP0005375_adipose_tissue_phenotype1.92330255
19MP0002933_joint_inflammation1.92250706
20MP0004185_abnormal_adipocyte_glucose1.85181957
21MP0005508_abnormal_skeleton_morphology1.82553446
22MP0002295_abnormal_pulmonary_circulatio1.76610875
23MP0002060_abnormal_skin_morphology1.70343137
24MP0001879_abnormal_lymphatic_vessel1.65676482
25MP0003646_muscle_fatigue1.61447246
26MP0003566_abnormal_cell_adhesion1.60613455
27MP0000003_abnormal_adipose_tissue1.60276008
28MP0005167_abnormal_blood-brain_barrier1.57260510
29MP0003724_increased_susceptibility_to1.55234968
30MP0002282_abnormal_trachea_morphology1.53931053
31MP0004134_abnormal_chest_morphology1.53641178
32MP0010329_abnormal_lipoprotein_level1.46464594
33MP0009780_abnormal_chondrocyte_physiolo1.38609864
34MP0000163_abnormal_cartilage_morphology1.38296133
35MP0006054_spinal_hemorrhage1.37523963
36MP0002139_abnormal_hepatobiliary_system1.31572299
37MP0002971_abnormal_brown_adipose1.29541903
38MP0005390_skeleton_phenotype1.26600156
39MP0009250_abnormal_appendicular_skeleto1.24125396
40MP0000343_altered_response_to1.23017002
41MP0005023_abnormal_wound_healing1.20070270
42MP0001533_abnormal_skeleton_physiology1.18815935
43MP0008004_abnormal_stomach_pH1.15922901
44MP0006138_congestive_heart_failure1.15818621
45MP0002115_abnormal_skeleton_extremities1.12234003
46MP0009115_abnormal_fat_cell1.11690770
47MP0002896_abnormal_bone_mineralization1.10962165
48MP0002127_abnormal_cardiovascular_syste1.10752084
49MP0000230_abnormal_systemic_arterial1.09960363
50MP0005365_abnormal_bile_salt1.07675881
51MP0000750_abnormal_muscle_regeneration1.07135087
52MP0002168_other_aberrant_phenotype1.04422514
53MP0003252_abnormal_bile_duct1.03101734
54MP0003045_fibrosis1.02017588
55MP0003191_abnormal_cellular_cholesterol1.01442217
56MP0005257_abnormal_intraocular_pressure1.00677129
57MP0005595_abnormal_vascular_smooth1.00338144
58MP0005164_abnormal_response_to0.99719702
59MP0000767_abnormal_smooth_muscle0.99701445
60MP0002638_abnormal_pupillary_reflex0.98435958
61MP0005623_abnormal_meninges_morphology0.97199264
62MP0010030_abnormal_orbit_morphology0.96930258
63MP0005360_urolithiasis0.96719068
64MP0004084_abnormal_cardiac_muscle0.94814271
65MP0001542_abnormal_bone_strength0.94195242
66MP0008775_abnormal_heart_ventricle0.93944159
67MP0005551_abnormal_eye_electrophysiolog0.93822250
68MP0002118_abnormal_lipid_homeostasis0.93215268
69MP0004087_abnormal_muscle_fiber0.91234951
70MP0000749_muscle_degeneration0.90786665
71MP0005388_respiratory_system_phenotype0.90659468
72MP0002133_abnormal_respiratory_system0.90659468
73MP0004085_abnormal_heartbeat0.90395329
74MP0005330_cardiomyopathy0.89773638
75MP0002998_abnormal_bone_remodeling0.88338185
76MP0005334_abnormal_fat_pad0.87408292
77MP0003091_abnormal_cell_migration0.85369473
78MP0002249_abnormal_larynx_morphology0.85195013
79MP0005385_cardiovascular_system_phenoty0.85084162
80MP0001544_abnormal_cardiovascular_syste0.85084162
81MP0002113_abnormal_skeleton_development0.84875983
82MP0003950_abnormal_plasma_membrane0.84122531
83MP0002909_abnormal_adrenal_gland0.83580475
84MP0004883_abnormal_blood_vessel0.83450957
85MP0001243_abnormal_dermal_layer0.83287136
86MP0005620_abnormal_muscle_contractility0.82232284
87MP0002876_abnormal_thyroid_physiology0.81345119
88MP0000049_abnormal_middle_ear0.79454077
89MP0003828_pulmonary_edema0.79323796
90MP0004036_abnormal_muscle_relaxation0.78865101
91MP0004484_altered_response_of0.77596031
92MP0010386_abnormal_urinary_bladder0.77589085
93MP0001986_abnormal_taste_sensitivity0.77302088
94MP0001270_distended_abdomen0.77062922
95MP0000759_abnormal_skeletal_muscle0.76751730
96MP0005253_abnormal_eye_physiology0.76015003
97MP0001661_extended_life_span0.74285827
98MP0003137_abnormal_impulse_conducting0.74119708
99MP0002128_abnormal_blood_circulation0.72846146
100MP0004019_abnormal_vitamin_homeostasis0.72285555
101MP0001177_atelectasis0.71932364
102MP0002089_abnormal_postnatal_growth/wei0.71783524
103MP0005369_muscle_phenotype0.71740172
104MP0004215_abnormal_myocardial_fiber0.71631725
105MP0002970_abnormal_white_adipose0.71616015
106MP0002972_abnormal_cardiac_muscle0.71459827
107MP0000249_abnormal_blood_vessel0.71195639
108MP0002254_reproductive_system_inflammat0.69417066
109MP0001299_abnormal_eye_distance/0.69142637
110MP0003690_abnormal_glial_cell0.67451725
111MP0002932_abnormal_joint_morphology0.65248691
112MP0001614_abnormal_blood_vessel0.65148168
113MP0003385_abnormal_body_wall0.64514667
114MP0005165_increased_susceptibility_to0.64498002
115MP0003186_abnormal_redox_activity0.63689032
116MP0002090_abnormal_vision0.63294807
117MP0003283_abnormal_digestive_organ0.63286238
118MP0003300_gastrointestinal_ulcer0.63166903
119MP0003329_amyloid_beta_deposits0.63156561
120MP0005171_absent_coat_pigmentation0.61604215
121MP0002106_abnormal_muscle_physiology0.61365310
122MP0001501_abnormal_sleep_pattern0.61295539
123MP0001756_abnormal_urination0.59615892
124MP0010630_abnormal_cardiac_muscle0.58305741
125MP0001502_abnormal_circadian_rhythm0.57751458
126MP0003795_abnormal_bone_structure0.54443298
127MP0000747_muscle_weakness0.53482262

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.12868017
2Premature rupture of membranes (HP:0001788)5.40563520
3Systemic lupus erythematosus (HP:0002725)4.80719289
4Broad metatarsal (HP:0001783)4.58465680
5Epiphyseal dysplasia (HP:0002656)4.29491743
6Ankle contracture (HP:0006466)4.20241378
7Neonatal short-limb short stature (HP:0008921)4.06089371
8Hypoplastic ischia (HP:0003175)4.02468533
9Follicular hyperkeratosis (HP:0007502)3.77805626
10Aortic dissection (HP:0002647)3.72635640
11Aortic aneurysm (HP:0004942)3.69545368
12Cervical subluxation (HP:0003308)3.68426771
13Abnormality of the ischium (HP:0003174)3.60232704
14Increased connective tissue (HP:0009025)3.44569600
15Vitreoretinal degeneration (HP:0000655)3.38671263
16Irregular epiphyses (HP:0010582)3.34901360
17Cupped ribs (HP:0000887)3.32575071
18Soft skin (HP:0000977)3.31397374
19Aortic valve stenosis (HP:0001650)3.21644465
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.21600571
21Type 1 muscle fiber predominance (HP:0003803)3.20859128
22Metaphyseal dysplasia (HP:0100255)3.20561664
23Spinal rigidity (HP:0003306)3.20368690
24Shallow orbits (HP:0000586)3.14256923
25Osteoarthritis (HP:0002758)3.12832506
26Ulnar deviation of the wrist (HP:0003049)3.01168970
27Ulnar claw (HP:0001178)2.96865080
28Cerebral aneurysm (HP:0004944)2.92881613
29Glomerulonephritis (HP:0000099)2.90037637
30Bladder diverticulum (HP:0000015)2.89240795
31Patent foramen ovale (HP:0001655)2.83766951
32Mitral valve prolapse (HP:0001634)2.80599690
33Flat acetabular roof (HP:0003180)2.79321047
34Irregular vertebral endplates (HP:0003301)2.78190511
35Vascular tortuosity (HP:0004948)2.76034333
36Wrist flexion contracture (HP:0001239)2.72574236
37Muscle fiber splitting (HP:0003555)2.71840188
38Nephritis (HP:0000123)2.69096066
39Increased variability in muscle fiber diameter (HP:0003557)2.68907892
40Papilledema (HP:0001085)2.65972876
41Beaking of vertebral bodies (HP:0004568)2.65739815
42Ectopia lentis (HP:0001083)2.62695220
43Dilatation of the ascending aorta (HP:0005111)2.60490777
44Acanthosis nigricans (HP:0000956)2.60253787
45Congenital stationary night blindness (HP:0007642)2.55760633
46Spinal cord compression (HP:0002176)2.54353433
47Coxa vara (HP:0002812)2.53145771
48Abnormal tarsal ossification (HP:0008369)2.51760720
49Complement deficiency (HP:0004431)2.51648233
50Vertebral compression fractures (HP:0002953)2.51529377
51Keratoconus (HP:0000563)2.50208997
52Increased corneal curvature (HP:0100692)2.50208997
53Atrophic scars (HP:0001075)2.49832629
54Overgrowth (HP:0001548)2.48116286
55Ovoid vertebral bodies (HP:0003300)2.47214301
56Atrial fibrillation (HP:0005110)2.44821064
57Persistence of primary teeth (HP:0006335)2.44595370
58Blue sclerae (HP:0000592)2.44054875
59Peritonitis (HP:0002586)2.43362892
60Arterial tortuosity (HP:0005116)2.40501935
61Striae distensae (HP:0001065)2.36674377
62Wormian bones (HP:0002645)2.35674283
63Small epiphyses (HP:0010585)2.33386710
64Emphysema (HP:0002097)2.32345066
65Abnormality of the acetabulum (HP:0003170)2.32098512
66Genu recurvatum (HP:0002816)2.31986834
67Flat capital femoral epiphysis (HP:0003370)2.31432019
68Aortic regurgitation (HP:0001659)2.30411148
69Slender build (HP:0001533)2.29487418
70Platyspondyly (HP:0000926)2.29169414
71Abnormality of skeletal muscle fiber size (HP:0012084)2.28128045
72Fragile skin (HP:0001030)2.27728801
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25677429
74Lumbar hyperlordosis (HP:0002938)2.25179423
75Abnormality of the odontoid process (HP:0003310)2.24744438
76Hypoplasia of the iris (HP:0007676)2.23495282
77Rectal prolapse (HP:0002035)2.22597927
78Joint stiffness (HP:0001387)2.21983026
79Abnormal cartilage morphology (HP:0002763)2.21892007
80Mildly elevated creatine phosphokinase (HP:0008180)2.21594605
81Primary atrial arrhythmia (HP:0001692)2.21366461
82Obstructive sleep apnea (HP:0002870)2.20966068
83Bone cyst (HP:0012062)2.19429960
84Hyperextensible skin (HP:0000974)2.19294703
85Limited hip movement (HP:0008800)2.18662490
86Protuberant abdomen (HP:0001538)2.18060303
87Aneurysm (HP:0002617)2.17175571
88Fibular hypoplasia (HP:0003038)2.15708231
89Biconcave vertebral bodies (HP:0004586)2.15370676
90Aplasia/Hypoplasia of the hallux (HP:0008362)2.15066928
91Infantile muscular hypotonia (HP:0008947)2.14678301
92Wide anterior fontanel (HP:0000260)2.14674474
93Scotoma (HP:0000575)2.13532273
94Arthropathy (HP:0003040)2.12598791
95Prominent supraorbital ridges (HP:0000336)2.12413028
96Hip contracture (HP:0003273)2.12048674
97Supraventricular arrhythmia (HP:0005115)2.11668812
98Joint laxity (HP:0001388)2.08870375
99Supraventricular tachycardia (HP:0004755)2.08630969
100Mild short stature (HP:0003502)2.06468412
101Oligomenorrhea (HP:0000876)2.06239560
102Bowel diverticulosis (HP:0005222)2.05673367
103Right ventricular cardiomyopathy (HP:0011663)2.05414709
104Myocardial infarction (HP:0001658)2.00398371
105Abnormality of dentin (HP:0010299)2.00136117
106Broad ribs (HP:0000885)2.00078509
107Coronal craniosynostosis (HP:0004440)1.99715472
108Hydroxyprolinuria (HP:0003080)1.99662864
109Abnormality of proline metabolism (HP:0010907)1.99662864
110Abnormality of the anterior chamber (HP:0000593)1.98805423
111Hypoalphalipoproteinemia (HP:0003233)1.98441599
112Bradycardia (HP:0001662)1.97921647
113Disproportionate tall stature (HP:0001519)1.97765316
114Lymphangioma (HP:0100764)1.97519798
115Spondylolisthesis (HP:0003302)1.97125838
116Prolonged QT interval (HP:0001657)1.96603387
117Genu varum (HP:0002970)1.96028936
118Abnormality of complement system (HP:0005339)1.94896496
119Bell-shaped thorax (HP:0001591)1.94712963
120Pigmentary retinal degeneration (HP:0001146)1.94427112
121Abnormal delivery (HP:0001787)1.93642546
122Abnormality of the epiphysis of the femoral head (HP:0010574)1.93321974
123Hypertriglyceridemia (HP:0002155)1.92741479
124Delayed epiphyseal ossification (HP:0002663)1.91974577
125Pulmonary artery stenosis (HP:0004415)1.91007266
126Abnormality of the femoral head (HP:0003368)1.90778221
127Short hallux (HP:0010109)1.89914650
128Mitral stenosis (HP:0001718)1.89631869
129Sudden death (HP:0001699)1.89063502
130Bronchomalacia (HP:0002780)1.88836022
131Deep venous thrombosis (HP:0002625)1.88501941
132Abnormal vertebral ossification (HP:0100569)1.86238535
133Carpal bone hypoplasia (HP:0001498)1.85923514
134Round ear (HP:0100830)1.85209411
135Thoracolumbar scoliosis (HP:0002944)1.85204197
136Abnormal foot bone ossification (HP:0010675)1.85175462
137Hyperglycinuria (HP:0003108)1.84293556
138Hypoplasia of the odontoid process (HP:0003311)1.83780509
139Mesomelia (HP:0003027)1.82358556
140Abnormality of the vertebral endplates (HP:0005106)1.81823047
141Abnormality of the lumbar spine (HP:0100712)1.81148761
142Xanthomatosis (HP:0000991)1.80211440
143Abnormality of femoral epiphyses (HP:0006499)1.78634477
144Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78634477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.42319854
2DDR24.15545069
3SIK13.72673167
4ERN13.32045717
5CAMK1D2.90689416
6GRK12.83254779
7TGFBR22.56319739
8TIE12.47206691
9MAP3K32.44979450
10BCKDK2.33764085
11LATS12.33134991
12PDGFRA2.32432207
13TTN2.29232646
14EPHB22.24983250
15CAMK1G2.21731817
16RIPK12.13492486
17STK38L2.04871258
18LMTK22.01382862
19MAPKAPK31.84622074
20MYLK1.72387883
21ADRBK21.69614753
22PRKD31.67585145
23ADRBK11.61153642
24LATS21.60169273
25FER1.60029328
26EPHA31.59672609
27GRK51.56031145
28MAP3K61.54122794
29FGFR41.50895864
30MST1R1.44417025
31MUSK1.39118080
32INSRR1.36641767
33EPHB11.35990355
34PKN21.35062739
35CDC42BPA1.33862446
36MAPK151.32201938
37PDK41.31732335
38PDK31.31732335
39PDK21.23826821
40NEK91.23547724
41STK241.22522105
42CAMK11.17395479
43DMPK1.17061113
44JAK11.15373888
45PHKG11.12699781
46PHKG21.12699781
47FGFR31.11786040
48MET1.08490962
49PRKAA21.07443326
50PIK3CA1.02884910
51PTK2B1.01963508
52PRKCH1.01636009
53FGFR21.00548124
54PAK21.00482418
55MARK10.99936017
56TRPM70.98493688
57ROCK10.98240147
58STK30.97371573
59PTK60.94196421
60HIPK20.91734110
61BMPR1B0.90251681
62KDR0.90012959
63PRKD20.86469272
64PRKG20.83697504
65PDGFRB0.82474773
66PKN10.82319965
67STK380.81112175
68GSK3A0.78724914
69NTRK30.77706359
70MAPK120.77682314
71AKT30.76305590
72MAP2K10.75264663
73CSK0.74784477
74PRKG10.74626623
75SGK2230.74619017
76SGK4940.74619017
77SGK20.74526628
78PRKD10.73555777
79PTK20.72322145
80PAK30.71835188
81DAPK30.71737129
82FRK0.68702158
83TESK10.67141734
84FGFR10.63803407
85MTOR0.60432317
86MARK20.59084490
87MAP2K30.57571925
88MAP4K20.57014993
89CDK60.56370298
90ILK0.56256815
91RPS6KA60.53983849
92RPS6KA20.53917189
93PRKAA10.52671748
94DAPK20.52644713
95NLK0.52642926
96RET0.50548977
97PRKACA0.50053491
98IGF1R0.50033239
99BMX0.49788160
100LRRK20.49659904
101TAOK30.48996885
102IRAK10.47701119
103ABL20.45833402
104BLK0.45514349
105JAK20.44921571
106RPS6KL10.44827436
107RPS6KC10.44827436
108MAPK30.44422484
109MAPKAPK50.44421817
110CAMK2A0.43262988
111MAPK10.42583331
112NUAK10.41323192
113PRKACG0.41048898
114NTRK10.40734129
115ACVR1B0.40482640
116OBSCN0.40354892
117WNK30.40231118
118INSR0.39963105
119MAP3K70.39217123
120ROCK20.38973949
121TAOK10.38734826
122SRC0.38538445
123GRK70.38260955
124CAMK2G0.37340089
125MAPK70.36818569
126STK390.36519756
127ERBB40.36118812
128PAK40.35589302
129PIK3CG0.34867330
130MAPK40.34662713
131PRKCA0.34553692
132PDPK10.33863059
133ERBB30.33068492
134PINK10.32912206
135CDK90.31909980
136PRKCE0.31767935
137IRAK30.30418754
138CAMK40.29649636
139NME10.28964154
140MOS0.28575100
141TGFBR10.27366758
142KIT0.26746887
143ABL10.26364729
144MAPK110.26324523

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.27664140
2PPAR signaling pathway_Homo sapiens_hsa033203.13528363
3Propanoate metabolism_Homo sapiens_hsa006402.80569002
4Fatty acid degradation_Homo sapiens_hsa000712.59267808
5Nitrogen metabolism_Homo sapiens_hsa009102.51229663
6Fatty acid metabolism_Homo sapiens_hsa012122.49505494
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.48531699
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45368284
9Protein digestion and absorption_Homo sapiens_hsa049742.33463228
10Fatty acid biosynthesis_Homo sapiens_hsa000612.15172044
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09492350
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07474190
13Phototransduction_Homo sapiens_hsa047442.02330495
14Complement and coagulation cascades_Homo sapiens_hsa046101.82656245
15Focal adhesion_Homo sapiens_hsa045101.78426545
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76263105
17Caffeine metabolism_Homo sapiens_hsa002321.73299986
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62091277
19Linoleic acid metabolism_Homo sapiens_hsa005911.61858882
20Tryptophan metabolism_Homo sapiens_hsa003801.54125802
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.48017936
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.46976918
23Malaria_Homo sapiens_hsa051441.45565081
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41668927
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39108076
26Glycerolipid metabolism_Homo sapiens_hsa005611.38203697
27beta-Alanine metabolism_Homo sapiens_hsa004101.36196296
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33815594
29Starch and sucrose metabolism_Homo sapiens_hsa005001.31349759
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30446001
31Pyruvate metabolism_Homo sapiens_hsa006201.29201866
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26467012
33Circadian rhythm_Homo sapiens_hsa047101.22735941
34Insulin resistance_Homo sapiens_hsa049311.15785460
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15283883
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14663251
37Arginine biosynthesis_Homo sapiens_hsa002201.13681157
38Peroxisome_Homo sapiens_hsa041461.13433006
39AMPK signaling pathway_Homo sapiens_hsa041521.13304852
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13132880
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11856179
42Dilated cardiomyopathy_Homo sapiens_hsa054141.10519269
43Pertussis_Homo sapiens_hsa051331.08832135
44Staphylococcus aureus infection_Homo sapiens_hsa051501.08482596
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07085137
46Butanoate metabolism_Homo sapiens_hsa006501.05892365
47Carbon metabolism_Homo sapiens_hsa012001.05368376
48Amoebiasis_Homo sapiens_hsa051461.03244882
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03102887
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.02486584
51TGF-beta signaling pathway_Homo sapiens_hsa043501.01225169
52Fat digestion and absorption_Homo sapiens_hsa049750.98792162
53Chemical carcinogenesis_Homo sapiens_hsa052040.97660855
54Calcium signaling pathway_Homo sapiens_hsa040200.96517929
55Proteoglycans in cancer_Homo sapiens_hsa052050.96192998
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94256790
57Insulin secretion_Homo sapiens_hsa049110.93700731
58Fatty acid elongation_Homo sapiens_hsa000620.93602381
59cAMP signaling pathway_Homo sapiens_hsa040240.93118333
60Sulfur metabolism_Homo sapiens_hsa009200.90686638
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90603090
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90402986
63Phenylalanine metabolism_Homo sapiens_hsa003600.90331675
64Mineral absorption_Homo sapiens_hsa049780.90200176
65Circadian entrainment_Homo sapiens_hsa047130.87067846
66Morphine addiction_Homo sapiens_hsa050320.86550895
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86329319
68Ether lipid metabolism_Homo sapiens_hsa005650.85867863
69Salivary secretion_Homo sapiens_hsa049700.84396601
70Oxytocin signaling pathway_Homo sapiens_hsa049210.84109407
71Lysine degradation_Homo sapiens_hsa003100.83977251
72Bile secretion_Homo sapiens_hsa049760.82470558
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81604760
74Dorso-ventral axis formation_Homo sapiens_hsa043200.78278024
75Tyrosine metabolism_Homo sapiens_hsa003500.77486583
76Adherens junction_Homo sapiens_hsa045200.76910270
77Cardiac muscle contraction_Homo sapiens_hsa042600.75477614
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74684061
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71902165
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.69484040
81Insulin signaling pathway_Homo sapiens_hsa049100.67924769
82Ovarian steroidogenesis_Homo sapiens_hsa049130.64809299
83GABAergic synapse_Homo sapiens_hsa047270.61416113
84Glucagon signaling pathway_Homo sapiens_hsa049220.61173597
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61126543
86Cocaine addiction_Homo sapiens_hsa050300.61094934
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60990265
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60873089
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60625782
90Ras signaling pathway_Homo sapiens_hsa040140.59703774
91Taste transduction_Homo sapiens_hsa047420.59038414
92Gastric acid secretion_Homo sapiens_hsa049710.57167410
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56384865
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56202640
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.56140510
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56096211
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55361088
98Serotonergic synapse_Homo sapiens_hsa047260.54756513
99Small cell lung cancer_Homo sapiens_hsa052220.52592060
100Glutamatergic synapse_Homo sapiens_hsa047240.52433628
101Pancreatic secretion_Homo sapiens_hsa049720.52166213
102Olfactory transduction_Homo sapiens_hsa047400.51806342
103Retinol metabolism_Homo sapiens_hsa008300.51332635
104Phagosome_Homo sapiens_hsa041450.51217987
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50291216
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49674279
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49341117
108Notch signaling pathway_Homo sapiens_hsa043300.48670651
109Viral myocarditis_Homo sapiens_hsa054160.48517984
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48448101
111Arginine and proline metabolism_Homo sapiens_hsa003300.48129849
112Renin secretion_Homo sapiens_hsa049240.47002204
113Axon guidance_Homo sapiens_hsa043600.46034026
114Thyroid hormone synthesis_Homo sapiens_hsa049180.45919620
115Basal cell carcinoma_Homo sapiens_hsa052170.45717082
116Hedgehog signaling pathway_Homo sapiens_hsa043400.44388417
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.44180000
118Melanogenesis_Homo sapiens_hsa049160.43842814
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.43189583
120Asthma_Homo sapiens_hsa053100.42964363
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42837583
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42658240
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41298528
124ABC transporters_Homo sapiens_hsa020100.41126058
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.40683232
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40655103
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40322886
128Bladder cancer_Homo sapiens_hsa052190.40096857
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39806504
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.39611839
131Hippo signaling pathway_Homo sapiens_hsa043900.39559695
132Histidine metabolism_Homo sapiens_hsa003400.37435226
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36887264
134Arachidonic acid metabolism_Homo sapiens_hsa005900.35996497
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.35611723
136Galactose metabolism_Homo sapiens_hsa000520.35524114
137Lysosome_Homo sapiens_hsa041420.32230789
138Prion diseases_Homo sapiens_hsa050200.32213108
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.31184796
140Toxoplasmosis_Homo sapiens_hsa051450.30918543
141HIF-1 signaling pathway_Homo sapiens_hsa040660.30701795
142Vitamin digestion and absorption_Homo sapiens_hsa049770.30662168
143Glutathione metabolism_Homo sapiens_hsa004800.30157327
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29187198
145Platelet activation_Homo sapiens_hsa046110.28463474
146Other glycan degradation_Homo sapiens_hsa005110.27964872
147Selenocompound metabolism_Homo sapiens_hsa004500.27254045
148Rap1 signaling pathway_Homo sapiens_hsa040150.26463735

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