PRELID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.22359109
2ribosomal small subunit assembly (GO:0000028)4.78820301
3purine nucleobase biosynthetic process (GO:0009113)4.67454127
4maturation of SSU-rRNA (GO:0030490)4.60318282
5ribosomal large subunit biogenesis (GO:0042273)4.56147710
6regulation of meiosis I (GO:0060631)4.54723119
7centriole replication (GO:0007099)4.52221547
8piRNA metabolic process (GO:0034587)4.45739006
9proteasome assembly (GO:0043248)4.42544272
10ribosomal small subunit biogenesis (GO:0042274)4.33005340
11formation of translation preinitiation complex (GO:0001731)4.30326788
12nucleobase biosynthetic process (GO:0046112)4.28406669
13viral transcription (GO:0019083)4.12336603
14translational termination (GO:0006415)4.06747155
15ribonucleoprotein complex biogenesis (GO:0022613)3.93715151
16positive regulation of histone H3-K4 methylation (GO:0051571)3.91779028
17DNA strand elongation involved in DNA replication (GO:0006271)3.91356606
18ribosome assembly (GO:0042255)3.87948656
19replication fork processing (GO:0031297)3.81300044
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77466675
21oxidative phosphorylation (GO:0006119)3.77195488
22telomere maintenance via semi-conservative replication (GO:0032201)3.76516404
23retinal cone cell development (GO:0046549)3.76420063
24rRNA modification (GO:0000154)3.74965962
25translational initiation (GO:0006413)3.72947126
26translational elongation (GO:0006414)3.72088280
27DNA strand elongation (GO:0022616)3.72003468
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68683269
29folic acid metabolic process (GO:0046655)3.65964147
30mitotic metaphase plate congression (GO:0007080)3.65924939
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64591499
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64093531
33ribosome biogenesis (GO:0042254)3.63501345
34termination of RNA polymerase III transcription (GO:0006386)3.55624761
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.55624761
36DNA replication checkpoint (GO:0000076)3.55286292
37DNA methylation involved in gamete generation (GO:0043046)3.54281670
38telomere maintenance via recombination (GO:0000722)3.52504988
39respiratory chain complex IV assembly (GO:0008535)3.49578195
40chromatin remodeling at centromere (GO:0031055)3.47732904
41rRNA processing (GO:0006364)3.46273817
42CENP-A containing nucleosome assembly (GO:0034080)3.45837325
43regulation of DNA methylation (GO:0044030)3.44074597
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43811671
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43723513
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43649594
47rRNA metabolic process (GO:0016072)3.40319893
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38158463
49negative regulation of ligase activity (GO:0051352)3.38158463
50fucose catabolic process (GO:0019317)3.33821785
51L-fucose metabolic process (GO:0042354)3.33821785
52L-fucose catabolic process (GO:0042355)3.33821785
53cotranslational protein targeting to membrane (GO:0006613)3.33311581
54negative regulation of transcription regulatory region DNA binding (GO:2000678)3.32342727
55protein targeting to ER (GO:0045047)3.31799090
56translation (GO:0006412)3.31718025
57regulation of cellular amino acid metabolic process (GO:0006521)3.30675997
58synapsis (GO:0007129)3.27780323
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27095598
60mitotic recombination (GO:0006312)3.26751939
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25013059
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24544544
63viral life cycle (GO:0019058)3.23375667
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21675388
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21402337
66cellular component biogenesis (GO:0044085)3.20268934
67DNA replication initiation (GO:0006270)3.19563368
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19551207
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19551207
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19551207
71kinetochore assembly (GO:0051382)3.19333112
72meiotic cell cycle (GO:0051321)3.18462592
73kinetochore organization (GO:0051383)3.18077055
74signal transduction involved in DNA damage checkpoint (GO:0072422)3.17244178
75signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17244178
76protein localization to endoplasmic reticulum (GO:0070972)3.16432913
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16429232
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16429232
79cellular protein complex disassembly (GO:0043624)3.14502025
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13585744
81positive regulation of guanylate cyclase activity (GO:0031284)3.12822431
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.11542793
83pseudouridine synthesis (GO:0001522)3.11153134
84transcription from RNA polymerase I promoter (GO:0006360)3.10288182
85resolution of meiotic recombination intermediates (GO:0000712)3.08993178
86positive regulation of ligase activity (GO:0051351)3.07552769
87double-strand break repair via homologous recombination (GO:0000724)3.07127030
88recombinational repair (GO:0000725)3.07112718
89regulation of guanylate cyclase activity (GO:0031282)3.06355953
90protein K6-linked ubiquitination (GO:0085020)3.05875871
91pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05581145
92termination of RNA polymerase I transcription (GO:0006363)3.04867946
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03929584
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03387453
95metaphase plate congression (GO:0051310)3.02053146
96regulation of female gonad development (GO:2000194)3.01491115
97centriole assembly (GO:0098534)2.99122671
98spliceosomal snRNP assembly (GO:0000387)2.98934039
99DNA replication-independent nucleosome assembly (GO:0006336)2.98765877
100DNA replication-independent nucleosome organization (GO:0034724)2.98765877
1017-methylguanosine mRNA capping (GO:0006370)2.98399348
102cytochrome complex assembly (GO:0017004)2.98358887
103regulation of mitochondrial translation (GO:0070129)2.98281170
104protein complex biogenesis (GO:0070271)2.96953799
105energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96708778
106ATP synthesis coupled proton transport (GO:0015986)2.96708778
107response to pheromone (GO:0019236)2.95858757
108telomere maintenance via telomere lengthening (GO:0010833)2.95224621
109male meiosis I (GO:0007141)2.94176429
110transcription-coupled nucleotide-excision repair (GO:0006283)2.93963192
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93316738
112antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93152865
113nucleotide transmembrane transport (GO:1901679)2.92490227
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92260324
115female gamete generation (GO:0007292)2.92044543
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91710853
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.91710853
118NADH dehydrogenase complex assembly (GO:0010257)2.91710853
119platelet dense granule organization (GO:0060155)2.91563114
120G1/S transition of mitotic cell cycle (GO:0000082)2.91185896
121cell cycle G1/S phase transition (GO:0044843)2.91185896
122DNA double-strand break processing (GO:0000729)2.90988502
123RNA capping (GO:0036260)2.90979208
1247-methylguanosine RNA capping (GO:0009452)2.90979208
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.90875696
126meiotic chromosome segregation (GO:0045132)2.88842103
127protein localization to kinetochore (GO:0034501)2.88648911
128reciprocal meiotic recombination (GO:0007131)2.87074952
129reciprocal DNA recombination (GO:0035825)2.87074952
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.87021526
131positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87021526
132positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87021526
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86188129
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.85587349
135nucleotide-excision repair, DNA gap filling (GO:0006297)2.82904376
136regulation of spindle organization (GO:0090224)2.82521430
137arginine metabolic process (GO:0006525)2.81825802
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.79889691
139translesion synthesis (GO:0019985)2.79591267
140photoreceptor cell maintenance (GO:0045494)2.79552649
141male meiosis (GO:0007140)2.79426078
142protein polyglutamylation (GO:0018095)2.79372564
143rRNA methylation (GO:0031167)2.79261724
144arginine catabolic process (GO:0006527)2.78932831
145mitochondrial respiratory chain complex assembly (GO:0033108)2.78441626
146histone exchange (GO:0043486)2.76663078
147regulation of mitotic spindle checkpoint (GO:1903504)2.72871539
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72871539
149transcription initiation from RNA polymerase I promoter (GO:0006361)2.72701674
150protein complex disassembly (GO:0043241)2.72022721
151regulation of histone H3-K9 methylation (GO:0051570)2.71289951
152postreplication repair (GO:0006301)2.69720204
153mitotic nuclear envelope disassembly (GO:0007077)2.69150025
154intestinal epithelial cell development (GO:0060576)2.67684966
155RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67587920
156regulation of ligase activity (GO:0051340)2.67569073
157positive regulation of cell cycle arrest (GO:0071158)2.67464908
158tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66962011
159RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66962011
160gene silencing by RNA (GO:0031047)2.63717055
161negative regulation of DNA-dependent DNA replication (GO:2000104)2.63070989
162establishment of chromosome localization (GO:0051303)2.63038162
163rRNA catabolic process (GO:0016075)2.61268056
164regulation of cilium movement (GO:0003352)2.57680275
165positive regulation of histone methylation (GO:0031062)2.56715182
166thrombin receptor signaling pathway (GO:0070493)2.55131838
167meiosis I (GO:0007127)2.52310851
168regulation of double-strand break repair via homologous recombination (GO:0010569)2.50537871
169branched-chain amino acid catabolic process (GO:0009083)2.50470633
170aggressive behavior (GO:0002118)2.50289227
171DNA replication-dependent nucleosome organization (GO:0034723)2.50140374
172DNA replication-dependent nucleosome assembly (GO:0006335)2.50140374
173centrosome organization (GO:0051297)2.49963634
174pyrimidine dimer repair (GO:0006290)2.49601883
175chromosome organization involved in meiosis (GO:0070192)2.48981998
176mismatch repair (GO:0006298)2.48819964
177multicellular organism reproduction (GO:0032504)2.48529834
178glucuronate metabolic process (GO:0019585)2.47263001
179uronic acid metabolic process (GO:0006063)2.47263001
180mannosylation (GO:0097502)2.46001006
181protein neddylation (GO:0045116)2.44767733
182positive regulation of prostaglandin secretion (GO:0032308)2.41396276
183DNA-dependent DNA replication (GO:0006261)2.40920035
184regulation of acrosome reaction (GO:0060046)2.39845582
185quinone biosynthetic process (GO:1901663)2.39627504
186cellular glucuronidation (GO:0052695)2.39404928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85240287
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06370200
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73507926
4EZH2_22144423_ChIP-Seq_EOC_Human3.58613314
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42595599
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.19809618
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.19183613
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18141819
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.17815669
10ZNF274_21170338_ChIP-Seq_K562_Hela3.17779696
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.04265933
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.04101215
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01330234
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89942778
15VDR_22108803_ChIP-Seq_LS180_Human2.86959721
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85480269
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80157699
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78251454
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63338491
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61477259
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.52548855
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.40593732
23EWS_26573619_Chip-Seq_HEK293_Human2.38927507
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37022518
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35575945
26VDR_23849224_ChIP-Seq_CD4+_Human2.34243841
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32557452
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23973225
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19217171
30XRN2_22483619_ChIP-Seq_HELA_Human2.17653382
31FUS_26573619_Chip-Seq_HEK293_Human2.15754859
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14000058
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04861609
34DCP1A_22483619_ChIP-Seq_HELA_Human2.03731821
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97856854
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96736685
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95209064
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93508417
39AR_21909140_ChIP-Seq_LNCAP_Human1.92119239
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88699236
41GABP_19822575_ChIP-Seq_HepG2_Human1.85942841
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84311819
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84239507
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.84015560
45FOXP3_21729870_ChIP-Seq_TREG_Human1.83343670
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.79966106
47* IRF1_19129219_ChIP-ChIP_H3396_Human1.73808892
48IGF1R_20145208_ChIP-Seq_DFB_Human1.72619301
49P300_19829295_ChIP-Seq_ESCs_Human1.69052143
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65642926
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.65118774
52GBX2_23144817_ChIP-Seq_PC3_Human1.63613823
53TTF2_22483619_ChIP-Seq_HELA_Human1.61366603
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60645344
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59916687
56TP53_22573176_ChIP-Seq_HFKS_Human1.54356013
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54079696
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51717050
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51388130
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51141873
61ELK1_19687146_ChIP-ChIP_HELA_Human1.49377735
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48473655
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47784455
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47678441
65CBP_20019798_ChIP-Seq_JUKART_Human1.47249727
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47249727
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46089158
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45650768
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41615240
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39459781
71HTT_18923047_ChIP-ChIP_STHdh_Human1.38510701
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38274997
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.38140836
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38115453
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37766416
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37227021
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37188395
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34688616
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31428373
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.31376971
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30507954
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.30507954
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30216007
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30169758
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28972480
86NANOG_19829295_ChIP-Seq_ESCs_Human1.28568131
87SOX2_19829295_ChIP-Seq_ESCs_Human1.28568131
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28066072
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.27629569
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27570324
91ER_23166858_ChIP-Seq_MCF-7_Human1.26975112
92KDM5A_27292631_Chip-Seq_BREAST_Human1.26598700
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25111212
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23521480
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21845241
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20266090
97TCF4_23295773_ChIP-Seq_U87_Human1.19883627
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19864993
99AR_20517297_ChIP-Seq_VCAP_Human1.19029701
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18304380
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.18239152
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17437065
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17355827
104EGR1_19374776_ChIP-ChIP_THP-1_Human1.17063465
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16657948
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15974758
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15039060
108STAT3_23295773_ChIP-Seq_U87_Human1.14695731
109* CDX2_22108803_ChIP-Seq_LS180_Human1.14568389
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14481553
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14352187
112* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14119047
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13793388
114AR_25329375_ChIP-Seq_VCAP_Human1.12192197
115TCF4_22108803_ChIP-Seq_LS180_Human1.11813202
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11652939
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.11479212
118CIITA_25753668_ChIP-Seq_RAJI_Human1.11081832
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10889835
120AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09907762
121TAF15_26573619_Chip-Seq_HEK293_Human1.09227188
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.08213696
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08025882
124* SMAD4_21799915_ChIP-Seq_A2780_Human1.07110904
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06651302
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06003408
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05992494
128SPI1_23547873_ChIP-Seq_NB4_Human1.05772198
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05428974
130* GATA3_21878914_ChIP-Seq_MCF-7_Human1.05006802
131* NANOG_20526341_ChIP-Seq_ESCs_Human1.04444516
132NCOR_22424771_ChIP-Seq_293T_Human1.04189567
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04048274
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03672249
135PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03524581
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03433479
137OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02266550
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01592092
139TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00349115
140* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00055081
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98747564
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98543227
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98363439
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.97941820
145ZNF263_19887448_ChIP-Seq_K562_Human0.97455309
146CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97001349
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94617097
148HOXB7_26014856_ChIP-Seq_BT474_Human0.94347288
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.92110798
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91816409
151GATA4_25053715_ChIP-Seq_YYC3_Human0.91635192
152E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90671500
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90265390
154BCAT_22108803_ChIP-Seq_LS180_Human0.90111043
155IRF8_22096565_ChIP-ChIP_GC-B_Human0.89709857
156* SMAD4_21741376_ChIP-Seq_EPCs_Human0.89638954
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.88456304
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88418837
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88001663
160IRF8_21731497_ChIP-ChIP_J774_Mouse0.87457976
161DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87322387
162TFEB_21752829_ChIP-Seq_HELA_Human0.87227682
163SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87197077
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86702460
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.86575631
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86015746
167* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85260136
168KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84583145
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84206214
170TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82950833
171MYC_18940864_ChIP-ChIP_HL60_Human0.82691483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.13809569
2MP0004957_abnormal_blastocyst_morpholog4.18025079
3MP0003111_abnormal_nucleus_morphology3.60425568
4MP0005360_urolithiasis3.48563995
5MP0006292_abnormal_olfactory_placode3.38962315
6MP0010094_abnormal_chromosome_stability2.98894755
7MP0003806_abnormal_nucleotide_metabolis2.97136107
8MP0003077_abnormal_cell_cycle2.92248077
9MP0002234_abnormal_pharynx_morphology2.68914501
10MP0009697_abnormal_copulation2.53585123
11MP0003878_abnormal_ear_physiology2.49922604
12MP0005377_hearing/vestibular/ear_phenot2.49922604
13MP0008789_abnormal_olfactory_epithelium2.46128442
14MP0008057_abnormal_DNA_replication2.39428560
15MP0000490_abnormal_crypts_of2.32400361
16MP0008058_abnormal_DNA_repair2.29831264
17MP0003718_maternal_effect2.24073720
18MP0008932_abnormal_embryonic_tissue2.18365004
19MP0008007_abnormal_cellular_replicative2.11477495
20MP0002139_abnormal_hepatobiliary_system2.10990551
21MP0003195_calcinosis2.08175511
22MP0004043_abnormal_pH_regulation2.07585030
23MP0005085_abnormal_gallbladder_physiolo2.06891939
24MP0003315_abnormal_perineum_morphology2.03666985
25MP0002396_abnormal_hematopoietic_system1.95508739
26MP0003123_paternal_imprinting1.93518462
27MP0010352_gastrointestinal_tract_polyps1.93215456
28MP0003186_abnormal_redox_activity1.91037446
29MP0001730_embryonic_growth_arrest1.90033397
30MP0009333_abnormal_splenocyte_physiolog1.87202125
31MP0008872_abnormal_physiological_respon1.83381938
32MP0005646_abnormal_pituitary_gland1.82844017
33MP0001666_abnormal_nutrient_absorption1.78961154
34MP0003567_abnormal_fetal_cardiomyocyte1.78204980
35MP0005499_abnormal_olfactory_system1.77746908
36MP0005394_taste/olfaction_phenotype1.77746908
37MP0005410_abnormal_fertilization1.74171062
38MP0002102_abnormal_ear_morphology1.66221039
39MP0005551_abnormal_eye_electrophysiolog1.61810327
40MP0005451_abnormal_body_composition1.61177265
41MP0003786_premature_aging1.58411034
42MP0009785_altered_susceptibility_to1.57587430
43MP0003183_abnormal_peptide_metabolism1.57584860
44MP0001835_abnormal_antigen_presentation1.57443337
45MP0010155_abnormal_intestine_physiology1.56080157
46MP0008775_abnormal_heart_ventricle1.53854949
47MP0000350_abnormal_cell_proliferation1.51724691
48MP0003941_abnormal_skin_development1.50099162
49MP0000631_abnormal_neuroendocrine_gland1.48666990
50MP0005671_abnormal_response_to1.47719659
51MP0002160_abnormal_reproductive_system1.46691830
52MP0001929_abnormal_gametogenesis1.42272309
53MP0008875_abnormal_xenobiotic_pharmacok1.36910667
54MP0001293_anophthalmia1.36128655
55MP0003646_muscle_fatigue1.35290347
56MP0003950_abnormal_plasma_membrane1.34510963
57MP0005397_hematopoietic_system_phenotyp1.34264788
58MP0001545_abnormal_hematopoietic_system1.34264788
59MP0004084_abnormal_cardiac_muscle1.33381221
60MP0002132_abnormal_respiratory_system1.32656808
61MP0009840_abnormal_foam_cell1.32401740
62MP0002210_abnormal_sex_determination1.31395891
63MP0006036_abnormal_mitochondrial_physio1.31240864
64MP0005380_embryogenesis_phenotype1.29062811
65MP0001672_abnormal_embryogenesis/_devel1.29062811
66MP0006072_abnormal_retinal_apoptosis1.29039479
67MP0005645_abnormal_hypothalamus_physiol1.28508012
68MP0003984_embryonic_growth_retardation1.27213414
69MP0002138_abnormal_hepatobiliary_system1.24662641
70MP0002088_abnormal_embryonic_growth/wei1.24494121
71MP0000653_abnormal_sex_gland1.23395299
72MP0005332_abnormal_amino_acid1.22444176
73MP0003866_abnormal_defecation1.22298947
74MP0005636_abnormal_mineral_homeostasis1.22103485
75MP0000383_abnormal_hair_follicle1.20941718
76MP0002938_white_spotting1.20514013
77MP0002837_dystrophic_cardiac_calcinosis1.20075230
78MP0003252_abnormal_bile_duct1.20043303
79MP0004215_abnormal_myocardial_fiber1.18384938
80MP0000566_synostosis1.17694278
81MP0001697_abnormal_embryo_size1.17049326
82MP0004264_abnormal_extraembryonic_tissu1.16046151
83MP0000313_abnormal_cell_death1.15020402
84MP0000427_abnormal_hair_cycle1.14700217
85MP0003221_abnormal_cardiomyocyte_apopto1.14518384
86MP0000477_abnormal_intestine_morphology1.12580923
87MP0006035_abnormal_mitochondrial_morpho1.11455327
88MP0005389_reproductive_system_phenotype1.10857743
89MP0002080_prenatal_lethality1.10528411
90MP0001664_abnormal_digestion1.09112460
91MP0003698_abnormal_male_reproductive1.09094517
92MP0002233_abnormal_nose_morphology1.08173266
93MP0002019_abnormal_tumor_incidence1.08103318
94MP0005365_abnormal_bile_salt1.08061593
95MP0001145_abnormal_male_reproductive1.07116151
96MP0003121_genomic_imprinting1.06546926
97MP0002148_abnormal_hypersensitivity_rea1.05667543
98MP0002086_abnormal_extraembryonic_tissu1.05474019
99MP0003763_abnormal_thymus_physiology1.04666401
100MP0002006_tumorigenesis1.04607410
101MP0008995_early_reproductive_senescence1.03860762
102MP0008260_abnormal_autophagy1.03641344
103MP0001764_abnormal_homeostasis1.00790854
104MP0006276_abnormal_autonomic_nervous0.98989053
105MP0003828_pulmonary_edema0.98849283
106MP0001853_heart_inflammation0.98812839
107MP0010307_abnormal_tumor_latency0.98397957
108MP0005084_abnormal_gallbladder_morpholo0.97952599
109MP0010678_abnormal_skin_adnexa0.97284692
110MP0002166_altered_tumor_susceptibility0.96728816
111MP0006054_spinal_hemorrhage0.96140223
112MP0005025_abnormal_response_to0.96022491
113MP0001984_abnormal_olfaction0.96015740
114MP0002638_abnormal_pupillary_reflex0.95801934
115MP0002398_abnormal_bone_marrow0.95736880
116MP0005253_abnormal_eye_physiology0.95717036
117MP0001119_abnormal_female_reproductive0.95606467
118MP0004808_abnormal_hematopoietic_stem0.95488814
119MP0003191_abnormal_cellular_cholesterol0.95007777
120MP0003656_abnormal_erythrocyte_physiolo0.94930936
121MP0000230_abnormal_systemic_arterial0.94285850
122MP0001873_stomach_inflammation0.93131200
123MP0002163_abnormal_gland_morphology0.92487337
124MP0002722_abnormal_immune_system0.92366002
125MP0003699_abnormal_female_reproductive0.91194136
126MP0002095_abnormal_skin_pigmentation0.90521157
127MP0003436_decreased_susceptibility_to0.87930513
128MP0001800_abnormal_humoral_immune0.87829704
129MP0000689_abnormal_spleen_morphology0.87553261
130MP0002452_abnormal_antigen_presenting0.86392947
131MP0002429_abnormal_blood_cell0.85552007
132MP0002723_abnormal_immune_serum0.81860153
133MP0004019_abnormal_vitamin_homeostasis0.81518338
134MP0001819_abnormal_immune_cell0.81342558
135MP0005075_abnormal_melanosome_morpholog0.81261035
136MP0000685_abnormal_immune_system0.80060020
137MP0005647_abnormal_sex_gland0.78865625
138MP0002420_abnormal_adaptive_immunity0.77904606
139MP0005000_abnormal_immune_tolerance0.77592820
140MP0003890_abnormal_embryonic-extraembry0.77503503
141MP0002161_abnormal_fertility/fecundity0.76373663
142MP0000716_abnormal_immune_system0.76196731
143MP0000358_abnormal_cell_content/0.76076992
144MP0001529_abnormal_vocalization0.75929731
145MP0004142_abnormal_muscle_tone0.75404354
146MP0010329_abnormal_lipoprotein_level0.74747482
147MP0001501_abnormal_sleep_pattern0.74735599
148MP0003937_abnormal_limbs/digits/tail_de0.74593789
149MP0002009_preneoplasia0.73577076
150MP0002085_abnormal_embryonic_tissue0.73350469
151MP0000015_abnormal_ear_pigmentation0.73229706
152MP0005266_abnormal_metabolism0.73072084
153MP0004782_abnormal_surfactant_physiolog0.72625130
154MP0001542_abnormal_bone_strength0.71834954
155MP0001727_abnormal_embryo_implantation0.71366318
156MP0000647_abnormal_sebaceous_gland0.70470937
157MP0003283_abnormal_digestive_organ0.70338761
158MP0009643_abnormal_urine_homeostasis0.69425365
159MP0008877_abnormal_DNA_methylation0.69371205
160MP0001663_abnormal_digestive_system0.68881410
161MP0008469_abnormal_protein_level0.68399181
162MP0001756_abnormal_urination0.68031956
163MP0004147_increased_porphyrin_level0.67010518
164MP0005379_endocrine/exocrine_gland_phen0.66794317
165MP0001845_abnormal_inflammatory_respons0.66790333
166MP0000750_abnormal_muscle_regeneration0.66162764
167MP0001661_extended_life_span0.65242435
168MP0004197_abnormal_fetal_growth/weight/0.63448212
169MP0000703_abnormal_thymus_morphology0.63423255
170MP0005395_other_phenotype0.63383040
171MP0005319_abnormal_enzyme/_coenzyme0.62372256
172MP0000372_irregular_coat_pigmentation0.61815215
173MP0000537_abnormal_urethra_morphology0.61767566

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.54634291
2Abnormal number of erythroid precursors (HP:0012131)4.41377086
3Birth length less than 3rd percentile (HP:0003561)4.16379199
4Breast hypoplasia (HP:0003187)3.86420294
5Reticulocytopenia (HP:0001896)3.78211005
6Multiple enchondromatosis (HP:0005701)3.54706027
7Pustule (HP:0200039)3.54567541
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.36365273
9Acanthocytosis (HP:0001927)3.32820784
10Pancreatic cysts (HP:0001737)3.29036565
11Rough bone trabeculation (HP:0100670)3.25157251
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24696248
13Macrocytic anemia (HP:0001972)3.22101790
14Hepatic necrosis (HP:0002605)3.20042267
15Carpal bone hypoplasia (HP:0001498)3.11126286
16Abnormality of midbrain morphology (HP:0002418)3.09638548
17Molar tooth sign on MRI (HP:0002419)3.09638548
18Pancreatic fibrosis (HP:0100732)3.08199469
19Supernumerary spleens (HP:0009799)3.00742619
20Oral leukoplakia (HP:0002745)2.99092588
21Acute necrotizing encephalopathy (HP:0006965)2.97557967
22Mitochondrial inheritance (HP:0001427)2.95177245
23Hepatocellular necrosis (HP:0001404)2.88950831
24Increased CSF lactate (HP:0002490)2.88845094
25Pallor (HP:0000980)2.84823574
26Nausea (HP:0002018)2.83008345
27True hermaphroditism (HP:0010459)2.82881377
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76322835
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76322835
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75292716
31Impulsivity (HP:0100710)2.74158947
32Median cleft lip (HP:0000161)2.72332941
33Abnormal mitochondria in muscle tissue (HP:0008316)2.71932276
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.71817469
35Abnormality of the anterior horn cell (HP:0006802)2.71038000
36Degeneration of anterior horn cells (HP:0002398)2.71038000
37Dicarboxylic aciduria (HP:0003215)2.70876559
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70876559
39Petechiae (HP:0000967)2.69133261
40Cerebral hypomyelination (HP:0006808)2.68345346
41Trismus (HP:0000211)2.68339700
42Increased serum lactate (HP:0002151)2.68133103
43Short tibia (HP:0005736)2.68075311
44Increased hepatocellular lipid droplets (HP:0006565)2.66006978
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.63111469
46Patellar aplasia (HP:0006443)2.62947273
47Aplasia/Hypoplasia of the patella (HP:0006498)2.55037081
48Exertional dyspnea (HP:0002875)2.51878800
49Renal cortical cysts (HP:0000803)2.51857239
50Aplastic anemia (HP:0001915)2.51391987
51Lipid accumulation in hepatocytes (HP:0006561)2.50093127
52Microretrognathia (HP:0000308)2.48437189
53Abnormal trabecular bone morphology (HP:0100671)2.48227719
54Sparse eyelashes (HP:0000653)2.44609466
55Abnormality of the renal cortex (HP:0011035)2.42415859
56Facial hemangioma (HP:0000329)2.40441808
57Bile duct proliferation (HP:0001408)2.40329680
58Abnormal biliary tract physiology (HP:0012439)2.40329680
59Acute encephalopathy (HP:0006846)2.39973889
60Abnormality of the ileum (HP:0001549)2.39300464
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.39108577
62Hypoplasia of the fovea (HP:0007750)2.39108577
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.35860533
64Posterior subcapsular cataract (HP:0007787)2.33562630
65Abnormal protein glycosylation (HP:0012346)2.32573306
66Abnormal glycosylation (HP:0012345)2.32573306
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32573306
68Abnormal protein N-linked glycosylation (HP:0012347)2.32573306
69Medial flaring of the eyebrow (HP:0010747)2.28600991
70Abnormality of the umbilical cord (HP:0010881)2.27696006
71Duodenal stenosis (HP:0100867)2.27317385
72Small intestinal stenosis (HP:0012848)2.27317385
73Congenital stationary night blindness (HP:0007642)2.24649469
74Short middle phalanx of the 5th finger (HP:0004220)2.24006307
75Abnormality of the labia minora (HP:0012880)2.23474931
76Ureteral duplication (HP:0000073)2.22574149
773-Methylglutaconic aciduria (HP:0003535)2.21796789
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21622077
79Patent foramen ovale (HP:0001655)2.20638518
80Poikilocytosis (HP:0004447)2.20116237
81Abnormality of the fovea (HP:0000493)2.20046950
82Abnormality of the preputium (HP:0100587)2.19873486
83Nephronophthisis (HP:0000090)2.19140865
84Progressive macrocephaly (HP:0004481)2.19014005
85Poor head control (HP:0002421)2.16548811
86Lactic acidosis (HP:0003128)2.14940926
87Cheilitis (HP:0100825)2.13106753
88Hyperglycinemia (HP:0002154)2.08755343
89Hypoplastic iliac wings (HP:0002866)2.07898521
90Abnormality of vitamin B metabolism (HP:0004340)2.07072102
91Renal Fanconi syndrome (HP:0001994)2.06220838
92Lethargy (HP:0001254)2.05196423
93Ileus (HP:0002595)2.04562316
94Respiratory failure (HP:0002878)2.04145842
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03010236
96Abnormality of the vitamin B12 metabolism (HP:0004341)2.02821757
97Abnormality of glycine metabolism (HP:0010895)2.02312713
98Abnormality of serine family amino acid metabolism (HP:0010894)2.02312713
99Colon cancer (HP:0003003)2.01447489
100Secondary amenorrhea (HP:0000869)2.01419204
101Thrombocytosis (HP:0001894)2.01395664
102Abnormality of the renal medulla (HP:0100957)2.00594623
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99227346
104Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98683850
105Clubbing of toes (HP:0100760)1.98636687
106Methylmalonic aciduria (HP:0012120)1.98546753
107Exercise intolerance (HP:0003546)1.98240051
108Increased intramyocellular lipid droplets (HP:0012240)1.97980153
109Irregular epiphyses (HP:0010582)1.97939530
110Abnormality of the phalanges of the 5th finger (HP:0004213)1.97457270
111Cerebral edema (HP:0002181)1.97173189
112Abnormality of the duodenum (HP:0002246)1.96882771
113IgM deficiency (HP:0002850)1.96832109
114CNS demyelination (HP:0007305)1.95247983
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93955064
116Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93930857
117Hypophosphatemic rickets (HP:0004912)1.93542095
118Enlarged kidneys (HP:0000105)1.92959107
119Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.92895931
120Hyperglycinuria (HP:0003108)1.92311926
121Death in infancy (HP:0001522)1.92142653
122Abnormality of alanine metabolism (HP:0010916)1.90956126
123Hyperalaninemia (HP:0003348)1.90956126
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90956126
125Chromsome breakage (HP:0040012)1.90495075
126Decreased central vision (HP:0007663)1.90420967
127Chronic hepatic failure (HP:0100626)1.90071856
128Absent thumb (HP:0009777)1.90063065
129Respiratory difficulties (HP:0002880)1.89548712
130Cleft eyelid (HP:0000625)1.88760080
131Brushfield spots (HP:0001088)1.88325804
132Glycosuria (HP:0003076)1.88277240
133Abnormality of urine glucose concentration (HP:0011016)1.88277240
134Premature ovarian failure (HP:0008209)1.88264028
135Cystic liver disease (HP:0006706)1.87631340
136Attenuation of retinal blood vessels (HP:0007843)1.87099291
137Megaloblastic anemia (HP:0001889)1.86829023
138Central scotoma (HP:0000603)1.86169155
139Cellular immunodeficiency (HP:0005374)1.85947651
140Abnormality of the fetal cardiovascular system (HP:0010948)1.84898554
141Abnormal umbilical cord blood vessels (HP:0011403)1.84898554
142Single umbilical artery (HP:0001195)1.84898554
143Congenital sensorineural hearing impairment (HP:0008527)1.84869984
144Abnormality of chromosome stability (HP:0003220)1.84623459
145Congenital, generalized hypertrichosis (HP:0004540)1.83923980
146Bundle branch block (HP:0011710)1.83805797
147Meckel diverticulum (HP:0002245)1.83728958
148Generalized aminoaciduria (HP:0002909)1.83411056
149Abnormal cartilage morphology (HP:0002763)1.81523767
150Rhabdomyolysis (HP:0003201)1.81023573
151Increased muscle lipid content (HP:0009058)1.80785367
152Pancytopenia (HP:0001876)1.79989880
153Abnormalities of placenta or umbilical cord (HP:0001194)1.79940174
154Proximal tubulopathy (HP:0000114)1.79691875
155Bone marrow hypocellularity (HP:0005528)1.79104649
156Hypomagnesemia (HP:0002917)1.78076339
157Sclerocornea (HP:0000647)1.77762527
158Abolished electroretinogram (ERG) (HP:0000550)1.77681198
159Postaxial foot polydactyly (HP:0001830)1.77506436
160Methylmalonic acidemia (HP:0002912)1.77145858
161Absent radius (HP:0003974)1.76803941
162Congenital primary aphakia (HP:0007707)1.75144839
163Type I transferrin isoform profile (HP:0003642)1.73801679
164Congenital hepatic fibrosis (HP:0002612)1.73372242
165Premature graying of hair (HP:0002216)1.73290008
166Poikiloderma (HP:0001029)1.73283517
167Triphalangeal thumb (HP:0001199)1.72244714
168Neoplasm of the pancreas (HP:0002894)1.70502579
169Abnormality of the heme biosynthetic pathway (HP:0010472)1.70180322
170Reduced subcutaneous adipose tissue (HP:0003758)1.69989756
171Abnormality of fatty-acid metabolism (HP:0004359)1.69947492
172Abnormality of T cell physiology (HP:0011840)1.69607879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72014206
2WEE14.43855573
3FRK3.40944568
4NME23.36629246
5EIF2AK13.22928000
6STK163.00757660
7MAP4K22.76097564
8PINK12.61466493
9STK392.43374554
10ZAK2.26201865
11BRSK22.23338654
12PLK42.20555195
13TAOK32.17557011
14PIK3CA2.17441027
15EPHA22.16170838
16NEK22.11504419
17BMPR1B2.04485112
18TTK2.01026576
19TSSK61.97341205
20PIM21.89085600
21NEK11.88306339
22TRIM281.84408910
23SRPK11.77399609
24PLK11.72577380
25MST1R1.70711304
26VRK21.69158671
27TNIK1.67922926
28ADRBK21.65738958
29KDR1.65532641
30MAP2K21.60750333
31CDC71.57024047
32BRAF1.55727998
33WNK41.54767865
34ACVR1B1.52319399
35EIF2AK31.47697877
36NUAK11.45111011
37AURKB1.42245370
38STK38L1.41374670
39TESK21.41193618
40IRAK31.40045412
41VRK11.40026233
42OXSR11.34400519
43MAP3K81.31880825
44GRK11.27943422
45CSNK1G31.21743510
46MAP4K11.20785912
47DYRK31.20610459
48PLK31.15238587
49MET1.15077279
50BRSK11.14879474
51WNK31.14263880
52FLT31.13404460
53CSNK1G11.10740489
54OBSCN1.10294574
55MUSK1.09793107
56RPS6KB21.09647330
57AKT31.08644800
58CSNK1A1L1.08530242
59RPS6KA41.06301209
60MST41.06016100
61PLK21.04230825
62TEC1.04064387
63TESK11.03676767
64NME11.01926427
65INSRR1.00585410
66ARAF0.98152107
67STK240.96817871
68MYLK0.94309661
69CDK40.94132071
70ATR0.92842957
71BCKDK0.91392534
72MAPK130.91383711
73CHEK20.90548363
74CDK70.89872592
75CSNK1G20.89332198
76MATK0.89194699
77AURKA0.88513605
78EIF2AK20.88390568
79PBK0.88350974
80MAP3K40.87246849
81ABL20.85089546
82CDK80.84688773
83PDK20.83476161
84TXK0.82265364
85BCR0.81040706
86STK40.80201306
87ZAP700.78923272
88TYK20.78007478
89PIM10.77952824
90MAPKAPK30.77649869
91MAP3K110.77425296
92PAK40.76620805
93LMTK20.76210699
94ERBB30.73608847
95CSNK2A10.73311945
96TLK10.73117053
97ATM0.72509596
98TBK10.71989993
99CCNB10.68759136
100KIT0.68422457
101IKBKB0.68111970
102ILK0.68074156
103BLK0.67981538
104MAP2K70.67120313
105PRKCE0.67007618
106MAP3K120.66592645
107BMPR20.66080345
108PIK3CG0.63371870
109LATS10.62901723
110PAK10.62766602
111MKNK10.62461491
112FER0.61489309
113CDK90.61278090
114NEK90.60585283
115CHEK10.55465772
116SCYL20.52775110
117CSNK2A20.52325484
118RPS6KA50.51610369
119MAP2K30.50348538
120TIE10.49814677
121MKNK20.49236027
122ADRBK10.48121210
123JAK30.46955963
124STK100.46948130
125MAP3K140.45410421
126IRAK40.45349965
127TGFBR10.45105482
128PKN20.45034898
129PASK0.44323124
130LRRK20.43693263
131MAPKAPK50.43395162
132STK30.42261239
133PRKG20.40762653
134PRKCI0.40328751
135CSNK1D0.39427113
136DMPK0.38678455
137CDK20.38382139
138MARK30.37250700
139IKBKE0.36262623
140PRKACA0.35717407
141PNCK0.34928773
142CSNK1A10.34808891
143NEK60.34761566
144MAP2K60.34755048
145DAPK30.34020890
146NLK0.33915351
147PRKCQ0.33612039
148DYRK20.33294991
149PRKCA0.33251808
150PRKG10.32989208
151RAF10.32483769

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.13001020
2Ribosome_Homo sapiens_hsa030104.05202068
3DNA replication_Homo sapiens_hsa030303.65876892
4RNA polymerase_Homo sapiens_hsa030203.50375041
5Mismatch repair_Homo sapiens_hsa034303.16812663
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92512177
7Pyrimidine metabolism_Homo sapiens_hsa002402.55636176
8Homologous recombination_Homo sapiens_hsa034402.54085404
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.48510649
10RNA transport_Homo sapiens_hsa030132.30797130
11Spliceosome_Homo sapiens_hsa030402.23775226
12Base excision repair_Homo sapiens_hsa034102.16715514
13Nucleotide excision repair_Homo sapiens_hsa034202.10811433
14Propanoate metabolism_Homo sapiens_hsa006402.04677854
15Fatty acid elongation_Homo sapiens_hsa000621.94239813
16Parkinsons disease_Homo sapiens_hsa050121.91601704
17Oxidative phosphorylation_Homo sapiens_hsa001901.89232235
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83095360
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81506728
20Sulfur metabolism_Homo sapiens_hsa009201.78775271
21Nitrogen metabolism_Homo sapiens_hsa009101.75575446
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.74707839
23Cell cycle_Homo sapiens_hsa041101.68340650
24One carbon pool by folate_Homo sapiens_hsa006701.65135609
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.65121302
26Pentose phosphate pathway_Homo sapiens_hsa000301.64595672
27Vitamin B6 metabolism_Homo sapiens_hsa007501.57449843
28Butanoate metabolism_Homo sapiens_hsa006501.56714067
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.52076613
30Huntingtons disease_Homo sapiens_hsa050161.49249661
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48898866
32Folate biosynthesis_Homo sapiens_hsa007901.47185203
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46432079
34Retinol metabolism_Homo sapiens_hsa008301.43800197
35Phototransduction_Homo sapiens_hsa047441.43052889
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.41709358
37Fructose and mannose metabolism_Homo sapiens_hsa000511.38413541
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32735690
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32635961
40Purine metabolism_Homo sapiens_hsa002301.30310737
41Fanconi anemia pathway_Homo sapiens_hsa034601.28806859
42Basal transcription factors_Homo sapiens_hsa030221.28439491
43Sulfur relay system_Homo sapiens_hsa041221.25539413
44Peroxisome_Homo sapiens_hsa041461.24800152
45p53 signaling pathway_Homo sapiens_hsa041151.18263900
46Olfactory transduction_Homo sapiens_hsa047401.17951227
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10749585
48RNA degradation_Homo sapiens_hsa030181.10454558
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.10193637
50Carbon metabolism_Homo sapiens_hsa012001.06151804
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05184024
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04842661
53Alzheimers disease_Homo sapiens_hsa050101.04454216
54Non-homologous end-joining_Homo sapiens_hsa034501.03848604
55Ether lipid metabolism_Homo sapiens_hsa005651.03069778
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.00946892
57Tryptophan metabolism_Homo sapiens_hsa003800.99148398
58Glutathione metabolism_Homo sapiens_hsa004800.98211988
59Galactose metabolism_Homo sapiens_hsa000520.96392776
60Epstein-Barr virus infection_Homo sapiens_hsa051690.95279552
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93403519
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91605690
63Starch and sucrose metabolism_Homo sapiens_hsa005000.91476669
64Renin-angiotensin system_Homo sapiens_hsa046140.87281015
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.87153268
66Antigen processing and presentation_Homo sapiens_hsa046120.86498110
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86025435
68Arginine biosynthesis_Homo sapiens_hsa002200.83980577
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83145500
70Allograft rejection_Homo sapiens_hsa053300.83126216
71Legionellosis_Homo sapiens_hsa051340.80456280
72Biosynthesis of amino acids_Homo sapiens_hsa012300.80264947
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79707903
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77293708
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75361172
76Herpes simplex infection_Homo sapiens_hsa051680.75310583
77Regulation of autophagy_Homo sapiens_hsa041400.75064762
78Pyruvate metabolism_Homo sapiens_hsa006200.71878777
79Circadian rhythm_Homo sapiens_hsa047100.71131194
80Cardiac muscle contraction_Homo sapiens_hsa042600.70854584
81Fatty acid metabolism_Homo sapiens_hsa012120.66439108
82Ovarian steroidogenesis_Homo sapiens_hsa049130.66428782
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63197827
84Protein digestion and absorption_Homo sapiens_hsa049740.61797449
85Metabolic pathways_Homo sapiens_hsa011000.61712905
86mRNA surveillance pathway_Homo sapiens_hsa030150.60942042
87Fatty acid degradation_Homo sapiens_hsa000710.60801812
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60663076
89Arachidonic acid metabolism_Homo sapiens_hsa005900.58690114
90Protein export_Homo sapiens_hsa030600.57790302
91Selenocompound metabolism_Homo sapiens_hsa004500.56621312
92Linoleic acid metabolism_Homo sapiens_hsa005910.54792017
93Graft-versus-host disease_Homo sapiens_hsa053320.53828348
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53292327
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51170680
96Steroid biosynthesis_Homo sapiens_hsa001000.50811455
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50476138
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50274171
99Systemic lupus erythematosus_Homo sapiens_hsa053220.50113512
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48780579
101ABC transporters_Homo sapiens_hsa020100.48535938
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47988813
103Primary immunodeficiency_Homo sapiens_hsa053400.47577997
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46509252
105Glycerolipid metabolism_Homo sapiens_hsa005610.46331184
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45881003
107Chemical carcinogenesis_Homo sapiens_hsa052040.43887209
108Measles_Homo sapiens_hsa051620.43886957
109Fat digestion and absorption_Homo sapiens_hsa049750.42874412
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.42636996
111Sphingolipid metabolism_Homo sapiens_hsa006000.40251947
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39650324
113Mineral absorption_Homo sapiens_hsa049780.39435420
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39361643
115Taste transduction_Homo sapiens_hsa047420.39359048
116Tyrosine metabolism_Homo sapiens_hsa003500.38726114
117Viral carcinogenesis_Homo sapiens_hsa052030.37956426
118N-Glycan biosynthesis_Homo sapiens_hsa005100.37813751
119Thyroid cancer_Homo sapiens_hsa052160.37682206
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36755813
121Influenza A_Homo sapiens_hsa051640.31480823
122HIF-1 signaling pathway_Homo sapiens_hsa040660.31212033
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31072595
124Leishmaniasis_Homo sapiens_hsa051400.29331155
125Apoptosis_Homo sapiens_hsa042100.28834472
126Hematopoietic cell lineage_Homo sapiens_hsa046400.28822368
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26916196
128Arginine and proline metabolism_Homo sapiens_hsa003300.26515943
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.25593878
130Autoimmune thyroid disease_Homo sapiens_hsa053200.25191480
131Vitamin digestion and absorption_Homo sapiens_hsa049770.24923900
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24727379
133Caffeine metabolism_Homo sapiens_hsa002320.23944787
134Asthma_Homo sapiens_hsa053100.23853674
135Oocyte meiosis_Homo sapiens_hsa041140.22830619
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22376382
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21165617

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