PRELID1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)6.81663350
2cytidine deamination (GO:0009972)6.81663350
3cytidine metabolic process (GO:0046087)6.81663350
4DNA deamination (GO:0045006)6.37652266
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.03870520
6proteasome assembly (GO:0043248)5.50729819
7protein neddylation (GO:0045116)5.49356586
8positive regulation of T cell apoptotic process (GO:0070234)5.40987708
9eosinophil chemotaxis (GO:0048245)5.38700334
10macrophage chemotaxis (GO:0048246)5.35301674
11negative regulation by host of viral transcription (GO:0043922)5.28383613
12sequestering of actin monomers (GO:0042989)5.21390992
13eosinophil migration (GO:0072677)4.85021045
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.52885982
15positive regulation of lymphocyte apoptotic process (GO:0070230)4.51665052
16positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.51611741
17piRNA metabolic process (GO:0034587)4.36090735
18negative regulation of T cell differentiation in thymus (GO:0033085)4.28164129
19indole-containing compound catabolic process (GO:0042436)4.11174849
20indolalkylamine catabolic process (GO:0046218)4.11174849
21tryptophan catabolic process (GO:0006569)4.11174849
22male meiosis (GO:0007140)4.10468308
23regulation of lymphocyte chemotaxis (GO:1901623)4.01018358
24positive regulation of action potential (GO:0045760)3.95035078
25monocyte chemotaxis (GO:0002548)3.88538887
26kynurenine metabolic process (GO:0070189)3.80285593
27synapsis (GO:0007129)3.72973115
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72884919
29positive regulation of tolerance induction (GO:0002645)3.72666769
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.72647246
31regulation of mitochondrial translation (GO:0070129)3.66694567
32positive regulation of cellular response to oxidative stress (GO:1900409)3.62208202
33positive regulation of response to oxidative stress (GO:1902884)3.62208202
34chaperone-mediated protein transport (GO:0072321)3.48881380
35regulation of T cell tolerance induction (GO:0002664)3.46523809
36tryptophan metabolic process (GO:0006568)3.46222582
37negative regulation of organelle assembly (GO:1902116)3.38151128
38protein complex biogenesis (GO:0070271)3.36632930
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35472867
40ATP synthesis coupled proton transport (GO:0015986)3.35472867
41DNA methylation involved in gamete generation (GO:0043046)3.30458789
42male meiosis I (GO:0007141)3.24726290
43regulation of transcription from RNA polymerase I promoter (GO:0006356)3.24161600
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24038583
45positive regulation of calcium-mediated signaling (GO:0050850)3.22346220
46regulation of chemokine-mediated signaling pathway (GO:0070099)3.16760954
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13669772
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.13669772
49NADH dehydrogenase complex assembly (GO:0010257)3.13669772
50respiratory electron transport chain (GO:0022904)3.13450805
51positive regulation of lymphocyte migration (GO:2000403)3.10535257
52electron transport chain (GO:0022900)3.10366053
53axon ensheathment in central nervous system (GO:0032291)3.09926931
54central nervous system myelination (GO:0022010)3.09926931
55opioid receptor signaling pathway (GO:0038003)3.09424425
56base-excision repair, AP site formation (GO:0006285)3.07965138
57negative regulation of ligase activity (GO:0051352)3.07597591
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07597591
59mitochondrial respiratory chain complex assembly (GO:0033108)3.07444086
60positive regulation of prostaglandin secretion (GO:0032308)3.02192922
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95282118
62regulation of cellular amino acid metabolic process (GO:0006521)2.94813649
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91477280
64transcription from mitochondrial promoter (GO:0006390)2.90001828
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89690668
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89149159
67positive regulation of steroid hormone secretion (GO:2000833)2.88065852
68DNA demethylation (GO:0080111)2.87514943
69positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.87295460
70regulation of glucocorticoid secretion (GO:2000849)2.86381336
71positive regulation of leukocyte apoptotic process (GO:2000108)2.84996308
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84803081
73positive regulation of ligase activity (GO:0051351)2.83801247
74DNA double-strand break processing (GO:0000729)2.81525180
75inner mitochondrial membrane organization (GO:0007007)2.80144733
76regulation of lymphocyte migration (GO:2000401)2.79986586
77regulation of chronic inflammatory response (GO:0002676)2.78988207
78meiosis I (GO:0007127)2.78423370
79macroautophagy (GO:0016236)2.78019035
80regulation of mononuclear cell migration (GO:0071675)2.77898339
81retinal ganglion cell axon guidance (GO:0031290)2.74551364
82negative regulation of T cell receptor signaling pathway (GO:0050860)2.71421281
83positive regulation of natural killer cell mediated immunity (GO:0002717)2.71387410
84cellular response to interleukin-15 (GO:0071350)2.69539005
85positive regulation of DNA repair (GO:0045739)2.67799631
86negative regulation of astrocyte differentiation (GO:0048712)2.67373153
87regulation of tolerance induction (GO:0002643)2.66005637
88positive regulation of cell cycle arrest (GO:0071158)2.63753840
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62743971
90regulation of T cell apoptotic process (GO:0070232)2.62643075
91pyrimidine nucleoside catabolic process (GO:0046135)2.62557884
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60459568
93aromatic amino acid family catabolic process (GO:0009074)2.59695834
94protein homotrimerization (GO:0070207)2.57970660
95regulation of activation of Janus kinase activity (GO:0010533)2.57915026
96regulation of ubiquitin-protein transferase activity (GO:0051438)2.57499685
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.56131055
98amine catabolic process (GO:0009310)2.56020553
99cellular biogenic amine catabolic process (GO:0042402)2.56020553
100negative regulation of interleukin-1 beta production (GO:0032691)2.55973564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.15865844
2EZH2_22144423_ChIP-Seq_EOC_Human5.48749160
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.85809367
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.65446232
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.57689585
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25848891
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09944778
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97120341
9ZNF274_21170338_ChIP-Seq_K562_Hela2.93129610
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90298535
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70797638
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.40494617
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20735713
14HTT_18923047_ChIP-ChIP_STHdh_Human2.18590278
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15524201
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07041214
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88967705
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.84282743
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72525942
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70724743
21POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70360478
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.64467484
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63789443
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63429157
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63253448
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60192412
27AR_21572438_ChIP-Seq_LNCaP_Human1.59561180
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59524044
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56520459
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54709756
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51676241
32VDR_23849224_ChIP-Seq_CD4+_Human1.48617438
33MYC_18940864_ChIP-ChIP_HL60_Human1.46157924
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43653696
35PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.42655553
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.41549867
37FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41366629
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38010355
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35221998
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34321982
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.32704847
42P300_19829295_ChIP-Seq_ESCs_Human1.31821616
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30452698
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28259279
45TP53_22573176_ChIP-Seq_HFKS_Human1.26543954
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.26296510
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25948482
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22912261
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.22315229
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20878025
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17728659
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.17515321
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16483632
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.09172543
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09172543
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.06604294
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05519913
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04886252
59TAF15_26573619_Chip-Seq_HEK293_Human1.04424842
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02399486
61FUS_26573619_Chip-Seq_HEK293_Human1.02009020
62AR_20517297_ChIP-Seq_VCAP_Human1.00976808
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99280258
64GABP_19822575_ChIP-Seq_HepG2_Human0.97673819
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97392011
66NANOG_19829295_ChIP-Seq_ESCs_Human0.97045556
67SOX2_19829295_ChIP-Seq_ESCs_Human0.97045556
68ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94948104
69AR_25329375_ChIP-Seq_VCAP_Human0.93155816
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92997273
71ELK1_19687146_ChIP-ChIP_HELA_Human0.92409707
72PRDM14_20953172_ChIP-Seq_ESCs_Human0.92310180
73KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92230550
74GATA3_27048872_Chip-Seq_THYMUS_Human0.91278368
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90821684
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88167738
77GATA3_26560356_Chip-Seq_TH2_Human0.86656834
78VDR_22108803_ChIP-Seq_LS180_Human0.86209702
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85690122
80FLI1_21867929_ChIP-Seq_CD8_Mouse0.84908030
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84146304
82RNF2_27304074_Chip-Seq_NSC_Mouse0.83839505
83BCAT_22108803_ChIP-Seq_LS180_Human0.83423923
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82774759
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82066560
86SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81986611
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81867440
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81500055
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81203803
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.80983147
91ERG_20517297_ChIP-Seq_VCAP_Human0.80850111
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80599155
93ZFX_18555785_Chip-Seq_ESCs_Mouse0.80151163
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.80102960
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.79733211
96REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78722562
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77716342
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77715375
99CTCF_18555785_Chip-Seq_ESCs_Mouse0.77629536
100FOXP3_21729870_ChIP-Seq_TREG_Human0.77216722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.60564480
2MP0008875_abnormal_xenobiotic_pharmacok2.97952574
3MP0004145_abnormal_muscle_electrophysio2.73301088
4MP0003786_premature_aging2.41025933
5MP0005310_abnormal_salivary_gland2.35155355
6MP0000538_abnormal_urinary_bladder2.29371410
7MP0009333_abnormal_splenocyte_physiolog2.27667864
8MP0000372_irregular_coat_pigmentation2.14342565
9MP0001905_abnormal_dopamine_level2.12283987
10MP0003763_abnormal_thymus_physiology2.10639163
11MP0006072_abnormal_retinal_apoptosis2.09193190
12MP0006082_CNS_inflammation2.08373178
13MP0001188_hyperpigmentation2.06415477
14MP0002751_abnormal_autonomic_nervous2.05477878
15MP0005389_reproductive_system_phenotype2.01479194
16MP0008995_early_reproductive_senescence1.92776676
17MP0000566_synostosis1.90390369
18MP0002160_abnormal_reproductive_system1.89970666
19MP0009046_muscle_twitch1.88041734
20MP0001984_abnormal_olfaction1.82054693
21MP0003252_abnormal_bile_duct1.78489659
22MP0009745_abnormal_behavioral_response1.72489703
23MP0003186_abnormal_redox_activity1.71087719
24MP0009780_abnormal_chondrocyte_physiolo1.66389528
25MP0008007_abnormal_cellular_replicative1.65951176
26MP0001501_abnormal_sleep_pattern1.63060761
27MP0004147_increased_porphyrin_level1.62140740
28MP0004215_abnormal_myocardial_fiber1.61708655
29MP0005085_abnormal_gallbladder_physiolo1.59573068
30MP0001919_abnormal_reproductive_system1.58585709
31MP0010307_abnormal_tumor_latency1.49196569
32MP0002277_abnormal_respiratory_mucosa1.48332557
33MP0002837_dystrophic_cardiac_calcinosis1.48147113
34MP0008877_abnormal_DNA_methylation1.41264849
35MP0004742_abnormal_vestibular_system1.38333438
36MP0003283_abnormal_digestive_organ1.37158753
37MP0002638_abnormal_pupillary_reflex1.36762409
38MP0002210_abnormal_sex_determination1.35167839
39MP0008961_abnormal_basal_metabolism1.31887074
40MP0000749_muscle_degeneration1.29482555
41MP0003646_muscle_fatigue1.27486986
42MP0004924_abnormal_behavior1.25085202
43MP0005386_behavior/neurological_phenoty1.25085202
44MP0001502_abnormal_circadian_rhythm1.19853403
45MP0004142_abnormal_muscle_tone1.13432890
46MP0008058_abnormal_DNA_repair1.13251486
47MP0001929_abnormal_gametogenesis1.09869586
48MP0010386_abnormal_urinary_bladder1.08570667
49MP0003137_abnormal_impulse_conducting1.07991605
50MP0002928_abnormal_bile_duct1.04579041
51MP0001800_abnormal_humoral_immune1.04516872
52MP0005253_abnormal_eye_physiology1.03713456
53MP0000653_abnormal_sex_gland1.02810417
54MP0001970_abnormal_pain_threshold1.02759524
55MP0001790_abnormal_immune_system1.01731987
56MP0005387_immune_system_phenotype1.01731987
57MP0005623_abnormal_meninges_morphology1.00534989
58MP0001486_abnormal_startle_reflex1.00356884
59MP0002148_abnormal_hypersensitivity_rea0.98530917
60MP0003936_abnormal_reproductive_system0.96351247
61MP0001542_abnormal_bone_strength0.95133755
62MP0001958_emphysema0.94820592
63MP0002067_abnormal_sensory_capabilities0.94629305
64MP0002184_abnormal_innervation0.93762659
65MP0002420_abnormal_adaptive_immunity0.93562865
66MP0003718_maternal_effect0.92013774
67MP0001819_abnormal_immune_cell0.91480084
68MP0002249_abnormal_larynx_morphology0.91344554
69MP0010094_abnormal_chromosome_stability0.90937138
70MP0002723_abnormal_immune_serum0.90661064
71MP0000703_abnormal_thymus_morphology0.89633307
72MP0002272_abnormal_nervous_system0.89264338
73MP0004885_abnormal_endolymph0.88663123
74MP0002733_abnormal_thermal_nociception0.88559357
75MP0001764_abnormal_homeostasis0.88239451
76MP0004484_altered_response_of0.87299458
77MP0001145_abnormal_male_reproductive0.87026004
78MP0003698_abnormal_male_reproductive0.86303591
79MP0003136_yellow_coat_color0.85028823
80MP0001119_abnormal_female_reproductive0.84780408
81MP0006036_abnormal_mitochondrial_physio0.81954916
82MP0004036_abnormal_muscle_relaxation0.80948213
83MP0005646_abnormal_pituitary_gland0.80846712
84MP0001529_abnormal_vocalization0.80704042
85MP0003959_abnormal_lean_body0.77749926
86MP0002398_abnormal_bone_marrow0.76980662
87MP0005174_abnormal_tail_pigmentation0.76507973
88MP0003195_calcinosis0.74168604
89MP0002822_catalepsy0.73522902
90MP0002909_abnormal_adrenal_gland0.73010090
91MP0000631_abnormal_neuroendocrine_gland0.72927676
92MP0003693_abnormal_embryo_hatching0.71343410
93MP0006035_abnormal_mitochondrial_morpho0.70974452
94MP0001727_abnormal_embryo_implantation0.70181170
95MP0000716_abnormal_immune_system0.70082267
96MP0000689_abnormal_spleen_morphology0.69347716
97MP0009785_altered_susceptibility_to0.68634659
98MP0002405_respiratory_system_inflammati0.68206831
99MP0005000_abnormal_immune_tolerance0.68191113
100MP0002064_seizures0.67695672

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.88498672
2Gastrointestinal infarctions (HP:0005244)4.74099619
3Acute hepatic failure (HP:0006554)4.47502829
4Elevated erythrocyte sedimentation rate (HP:0003565)4.19104915
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.01885473
6Abnormal protein N-linked glycosylation (HP:0012347)4.01885473
7Abnormal protein glycosylation (HP:0012346)4.01885473
8Abnormal glycosylation (HP:0012345)4.01885473
9Optic neuritis (HP:0100653)3.42916099
10Retrobulbar optic neuritis (HP:0100654)3.42916099
11Arthropathy (HP:0003040)3.41228575
12Acute necrotizing encephalopathy (HP:0006965)3.37258252
13Abnormality of placental membranes (HP:0011409)3.25683412
14Amniotic constriction ring (HP:0009775)3.25683412
15Mitochondrial inheritance (HP:0001427)3.20066102
16Type 2 muscle fiber atrophy (HP:0003554)3.14382500
17Hemiplegia (HP:0002301)3.09559286
18Abnormality of T cell number (HP:0011839)3.08126836
19Hypoproteinemia (HP:0003075)2.97468578
20Increased CSF lactate (HP:0002490)2.95855964
21Abnormal mitochondria in muscle tissue (HP:0008316)2.88492040
22T lymphocytopenia (HP:0005403)2.86860691
23Acute encephalopathy (HP:0006846)2.80201275
24Orchitis (HP:0100796)2.79638406
25Abnormality of the prostate (HP:0008775)2.77759583
26Progressive macrocephaly (HP:0004481)2.73521678
27Abnormality of alanine metabolism (HP:0010916)2.71873878
28Hyperalaninemia (HP:0003348)2.71873878
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71873878
30Abnormality of lateral ventricle (HP:0030047)2.63448310
31Myositis (HP:0100614)2.62406459
32Short tibia (HP:0005736)2.62350075
33Carpal bone hypoplasia (HP:0001498)2.61082246
34Renal Fanconi syndrome (HP:0001994)2.60882638
35Muscle fiber atrophy (HP:0100295)2.60263596
36Increased hepatocellular lipid droplets (HP:0006565)2.57544324
37Gangrene (HP:0100758)2.55440371
38Amyotrophic lateral sclerosis (HP:0007354)2.52255071
39Absent/shortened dynein arms (HP:0200106)2.48951453
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.48951453
41Severe visual impairment (HP:0001141)2.47196293
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46425441
43IgG deficiency (HP:0004315)2.45462022
44Horizontal nystagmus (HP:0000666)2.36764196
45Lipid accumulation in hepatocytes (HP:0006561)2.35098191
46Diastasis recti (HP:0001540)2.34408803
47Optic disc pallor (HP:0000543)2.32007508
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.24847175
49Ulnar claw (HP:0001178)2.24802589
50Keratoconjunctivitis sicca (HP:0001097)2.20713417
51Beaking of vertebral bodies (HP:0004568)2.20547601
52Fibular aplasia (HP:0002990)2.17743628
53Gonadotropin excess (HP:0000837)2.17659714
54Aplasia/hypoplasia of the uterus (HP:0008684)2.17217052
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17137284
56Encephalitis (HP:0002383)2.13343296
57Cerebral edema (HP:0002181)2.09699900
58Abnormal number of incisors (HP:0011064)2.08865937
59Distal arthrogryposis (HP:0005684)2.08137222
60Peritonitis (HP:0002586)2.08115786
61Abnormality of midbrain morphology (HP:0002418)2.07931454
62Molar tooth sign on MRI (HP:0002419)2.07931454
63Posterior subcapsular cataract (HP:0007787)2.06977323
64Abdominal situs inversus (HP:0003363)2.05155570
65Abnormality of abdominal situs (HP:0011620)2.05155570
66Abnormal ciliary motility (HP:0012262)2.03819548
67Abolished electroretinogram (ERG) (HP:0000550)2.01533950
68Increased intramyocellular lipid droplets (HP:0012240)1.99596530
69Increased serum lactate (HP:0002151)1.97667479
70Episodic fever (HP:0001954)1.95975224
71Aplasia involving bones of the extremities (HP:0009825)1.95408802
72Aplasia involving bones of the upper limbs (HP:0009823)1.95408802
73Aplasia of the phalanges of the hand (HP:0009802)1.95408802
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94769782
75Hepatocellular necrosis (HP:0001404)1.94763775
76Keratoconjunctivitis (HP:0001096)1.92305375
77Popliteal pterygium (HP:0009756)1.91807456
78Hypoplasia of the uterus (HP:0000013)1.91776020
79Chest pain (HP:0100749)1.91510581
80Fetal akinesia sequence (HP:0001989)1.91070324
81Abnormality of male internal genitalia (HP:0000022)1.91042581
82True hermaphroditism (HP:0010459)1.90929197
83Nephronophthisis (HP:0000090)1.89644464
84Abnormal respiratory motile cilium morphology (HP:0005938)1.89566636
85Abnormal respiratory epithelium morphology (HP:0012253)1.89566636
86Abnormality of the middle phalanges of the toes (HP:0010183)1.88353556
87Atrophy/Degeneration involving motor neurons (HP:0007373)1.87385541
88Pancreatic cysts (HP:0001737)1.87040636
89Abnormality of T cells (HP:0002843)1.84646717
90Malignant hyperthermia (HP:0002047)1.83746089
91Attenuation of retinal blood vessels (HP:0007843)1.82944896
92Pendular nystagmus (HP:0012043)1.82290911
93Hemoptysis (HP:0002105)1.81304789
94Febrile seizures (HP:0002373)1.81291195
95Thyroiditis (HP:0100646)1.79596642
96X-linked dominant inheritance (HP:0001423)1.79095932
97Increased IgM level (HP:0003496)1.78859946
98Increased serum pyruvate (HP:0003542)1.77273327
99Lactic acidosis (HP:0003128)1.77259370
100Leukocytosis (HP:0001974)1.77020996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.30917372
2PNCK4.24345330
3ADRBK23.82667344
4GRK73.16394649
5KDR2.95698650
6BUB12.90888842
7EIF2AK32.85696832
8MET2.80265825
9CASK2.78684187
10ITK2.15147667
11BCKDK2.04095881
12NTRK12.02083186
13PLK21.66955596
14WNK31.66229069
15EPHB21.64530401
16TLK11.60443279
17CSF1R1.57876701
18PTK2B1.56849477
19SRPK11.55750533
20CDK191.54983033
21MAP3K91.52135558
22FRK1.51110245
23MAP4K21.49659689
24NUAK11.49510678
25MAPK131.48403056
26DYRK31.48331526
27BMX1.44289588
28PINK11.38453619
29EPHA41.33324455
30LIMK11.25726492
31OXSR11.15763320
32ERBB31.14430583
33ZAK1.10984579
34CAMK1G1.08424245
35NEK11.07786051
36EIF2AK11.04662311
37FGR1.04591166
38ROCK11.02927157
39PRKCQ0.99871404
40TSSK60.97967125
41PDGFRB0.93632440
42FGFR10.92536911
43STK390.86707400
44SYK0.84962332
45MAP2K20.83200023
46MAP4K10.82418733
47VRK20.80692109
48OBSCN0.80001508
49ERBB20.79923290
50AURKA0.77349026
51NTRK20.76909816
52PIK3CA0.76399367
53MATK0.75386034
54FGFR30.74826346
55STK160.69198228
56PASK0.68639830
57GRK10.68595990
58VRK10.68553479
59PDK20.61324412
60LCK0.60763209
61MAP2K70.59780792
62ATR0.59484402
63DYRK20.59250348
64TYRO30.58460636
65CAMK2A0.57395033
66IGF1R0.53089728
67MARK10.52504448
68MKNK20.52210440
69PRKCE0.51339661
70EGFR0.50626134
71WNK40.46863370
72TESK20.45408632
73INSR0.43373087
74BRSK20.43358841
75ADRBK10.42293132
76PHKG20.41203002
77PHKG10.41203002
78CDK30.40360280
79RPS6KA50.37990951
80RET0.37684504
81RPS6KA40.37204626
82GRK60.37026059
83CSNK2A10.36560669
84CSNK1G30.35844933
85INSRR0.35841977
86NTRK30.34456333
87PRKACA0.34163806
88KSR10.33401476
89PRKCA0.32452405
90ZAP700.32296760
91BRSK10.32274631
92PKN10.32089897
93CSK0.31393820
94IKBKE0.29923323
95DYRK1A0.28952152
96RPS6KA10.27272150
97STK38L0.26225839
98IKBKB0.26069588
99CSNK1E0.25889009
100WEE10.25563516

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.42201934
2Proteasome_Homo sapiens_hsa030504.47070121
3Oxidative phosphorylation_Homo sapiens_hsa001903.59861377
4Parkinsons disease_Homo sapiens_hsa050123.50215428
5Protein export_Homo sapiens_hsa030602.78967659
6Cardiac muscle contraction_Homo sapiens_hsa042602.74555546
7Primary immunodeficiency_Homo sapiens_hsa053402.60981706
8Autoimmune thyroid disease_Homo sapiens_hsa053202.42362035
9Huntingtons disease_Homo sapiens_hsa050162.24949904
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22869720
11Alzheimers disease_Homo sapiens_hsa050102.20552462
12Graft-versus-host disease_Homo sapiens_hsa053322.10278410
13Allograft rejection_Homo sapiens_hsa053302.06772395
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05936295
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.02287986
16RNA polymerase_Homo sapiens_hsa030201.90886282
17Antigen processing and presentation_Homo sapiens_hsa046121.77471674
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47658062
19Rheumatoid arthritis_Homo sapiens_hsa053231.44020434
20Ribosome_Homo sapiens_hsa030101.43693416
21Basal transcription factors_Homo sapiens_hsa030221.40320837
22N-Glycan biosynthesis_Homo sapiens_hsa005101.37615531
23T cell receptor signaling pathway_Homo sapiens_hsa046601.36159837
24Mismatch repair_Homo sapiens_hsa034301.30486049
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27998665
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25357489
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23464335
28Type I diabetes mellitus_Homo sapiens_hsa049401.23247406
29Phototransduction_Homo sapiens_hsa047441.19119708
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12264768
31Hematopoietic cell lineage_Homo sapiens_hsa046401.07154723
32Nucleotide excision repair_Homo sapiens_hsa034201.06513614
33RNA degradation_Homo sapiens_hsa030181.06107408
34Sulfur metabolism_Homo sapiens_hsa009201.04952810
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02959775
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.01608955
37Steroid biosynthesis_Homo sapiens_hsa001000.98428488
38Chemical carcinogenesis_Homo sapiens_hsa052040.97859438
39RNA transport_Homo sapiens_hsa030130.97739134
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91640322
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.83994800
42Tryptophan metabolism_Homo sapiens_hsa003800.81470404
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79654320
44Olfactory transduction_Homo sapiens_hsa047400.76685007
45Measles_Homo sapiens_hsa051620.76115617
46p53 signaling pathway_Homo sapiens_hsa041150.72913061
47Linoleic acid metabolism_Homo sapiens_hsa005910.72557215
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71034717
49Peroxisome_Homo sapiens_hsa041460.69751966
50Viral myocarditis_Homo sapiens_hsa054160.69011186
51Salmonella infection_Homo sapiens_hsa051320.67825875
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66089925
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.64631903
54Spliceosome_Homo sapiens_hsa030400.64464760
55Purine metabolism_Homo sapiens_hsa002300.61714904
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60831846
57Fanconi anemia pathway_Homo sapiens_hsa034600.60608258
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60129035
59Retinol metabolism_Homo sapiens_hsa008300.59647332
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59484293
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57230035
62Ether lipid metabolism_Homo sapiens_hsa005650.53943864
63Oocyte meiosis_Homo sapiens_hsa041140.51189968
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50402306
65Pyrimidine metabolism_Homo sapiens_hsa002400.50129075
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49341629
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47181721
68Asthma_Homo sapiens_hsa053100.45426607
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.44628868
70Metabolic pathways_Homo sapiens_hsa011000.43851181
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43006912
72Chemokine signaling pathway_Homo sapiens_hsa040620.42655240
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37957018
74Circadian rhythm_Homo sapiens_hsa047100.37392032
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37327971
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.36633689
77Prion diseases_Homo sapiens_hsa050200.36361093
78Sphingolipid metabolism_Homo sapiens_hsa006000.33897860
79Systemic lupus erythematosus_Homo sapiens_hsa053220.33783579
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31630799
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30446801
82Tyrosine metabolism_Homo sapiens_hsa003500.30043409
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30022033
84Epstein-Barr virus infection_Homo sapiens_hsa051690.29551282
85Taste transduction_Homo sapiens_hsa047420.29434178
86Regulation of autophagy_Homo sapiens_hsa041400.29293087
87DNA replication_Homo sapiens_hsa030300.28668365
88Apoptosis_Homo sapiens_hsa042100.27553065
89Nitrogen metabolism_Homo sapiens_hsa009100.27267710
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25872098
91Herpes simplex infection_Homo sapiens_hsa051680.25223898
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21003383
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20649828
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20224126
95Homologous recombination_Homo sapiens_hsa034400.19887777
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17980617
97Collecting duct acid secretion_Homo sapiens_hsa049660.17281925
98Shigellosis_Homo sapiens_hsa051310.17276169
99Base excision repair_Homo sapiens_hsa034100.17041160
100Axon guidance_Homo sapiens_hsa043600.14455547

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