PRELID1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.96009618
2cytidine metabolic process (GO:0046087)4.72178316
3cytidine catabolic process (GO:0006216)4.72178316
4cytidine deamination (GO:0009972)4.72178316
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69282350
6ATP synthesis coupled proton transport (GO:0015986)4.23414792
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23414792
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22645009
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.17141884
10proteasome assembly (GO:0043248)4.11594070
11iron-sulfur cluster assembly (GO:0016226)3.95766584
12metallo-sulfur cluster assembly (GO:0031163)3.95766584
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80287873
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80287873
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.71380677
16positive regulation of T cell apoptotic process (GO:0070234)3.67901024
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63830848
18chaperone-mediated protein transport (GO:0072321)3.58714271
19regulation of cellular amino acid metabolic process (GO:0006521)3.56078527
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51647146
21protein neddylation (GO:0045116)3.48580255
22protein complex biogenesis (GO:0070271)3.42553330
23respiratory electron transport chain (GO:0022904)3.41645478
24Arp2/3 complex-mediated actin nucleation (GO:0034314)3.36841362
25electron transport chain (GO:0022900)3.35339516
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32811269
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31952531
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.30104866
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27514601
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23357523
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23021469
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23021469
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23021469
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21457225
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21457225
36negative regulation of ligase activity (GO:0051352)3.20489498
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20489498
38antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17335689
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15242619
40sequestering of actin monomers (GO:0042989)3.12724616
41mitochondrial respiratory chain complex assembly (GO:0033108)3.12543751
42ribosomal small subunit assembly (GO:0000028)3.11411290
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.09739961
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09739961
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.09189370
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08691196
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07352544
48protein deneddylation (GO:0000338)3.04841411
49regulation of cellular respiration (GO:0043457)3.03121190
50positive regulation of lymphocyte apoptotic process (GO:0070230)3.03021514
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.01777137
52NADH dehydrogenase complex assembly (GO:0010257)3.01777137
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01777137
54cytochrome complex assembly (GO:0017004)2.98082067
55respiratory chain complex IV assembly (GO:0008535)2.96905499
56peptidyl-histidine modification (GO:0018202)2.96568124
57actin nucleation (GO:0045010)2.93754108
58cullin deneddylation (GO:0010388)2.93465305
59response to interferon-beta (GO:0035456)2.90649712
60platelet dense granule organization (GO:0060155)2.90451931
61oxidative phosphorylation (GO:0006119)2.87398123
62regulation of regulatory T cell differentiation (GO:0045589)2.87020018
63ubiquinone biosynthetic process (GO:0006744)2.85432454
64deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.83672082
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.82341248
66termination of RNA polymerase III transcription (GO:0006386)2.82341248
67purine deoxyribonucleotide catabolic process (GO:0009155)2.80177699
68regulation of chronic inflammatory response (GO:0002676)2.79485532
69mannosylation (GO:0097502)2.79414627
70positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78542481
71protein-cofactor linkage (GO:0018065)2.77255278
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76732739
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75097668
74base-excision repair, AP site formation (GO:0006285)2.73941677
75cellular response to interferon-beta (GO:0035458)2.73073017
76positive regulation of ligase activity (GO:0051351)2.72957134
77protein targeting to mitochondrion (GO:0006626)2.72682684
78positive regulation of interleukin-8 secretion (GO:2000484)2.71943354
79regulation of isotype switching to IgG isotypes (GO:0048302)2.71097847
80hydrogen ion transmembrane transport (GO:1902600)2.70514779
81pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70307620
82L-methionine biosynthetic process (GO:0071265)2.70231620
83amino acid salvage (GO:0043102)2.70231620
84L-methionine salvage (GO:0071267)2.70231620
85rRNA modification (GO:0000154)2.69642297
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.65633171
87GPI anchor biosynthetic process (GO:0006506)2.64419333
88regulation of T cell apoptotic process (GO:0070232)2.63829095
89deoxyribonucleotide catabolic process (GO:0009264)2.63049589
90ubiquinone metabolic process (GO:0006743)2.62797708
91protein localization to mitochondrion (GO:0070585)2.61290490
92establishment of protein localization to mitochondrion (GO:0072655)2.61200980
93GPI anchor metabolic process (GO:0006505)2.58977549
94proton transport (GO:0015992)2.58691177
95purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.58421144
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.57421754
97GDP-mannose metabolic process (GO:0019673)2.54266498
98deoxyribose phosphate catabolic process (GO:0046386)2.54047315
99water-soluble vitamin biosynthetic process (GO:0042364)2.53902412
100regulation of cellular amine metabolic process (GO:0033238)2.53641134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48126728
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.38637368
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.33766370
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31743920
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82972411
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80842974
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.80173724
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.45556524
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.10781231
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97309106
11VDR_23849224_ChIP-Seq_CD4+_Human2.88525011
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77532019
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64576369
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.57889201
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51289631
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47483203
17FOXP3_21729870_ChIP-Seq_TREG_Human2.45622024
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36100755
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.30945334
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19758269
21ELK1_19687146_ChIP-ChIP_HELA_Human2.05351361
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.05219241
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04855137
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03328724
25GABP_19822575_ChIP-Seq_HepG2_Human1.99358352
26DCP1A_22483619_ChIP-Seq_HELA_Human1.98366733
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.92147463
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90651391
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88550999
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81700312
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81644253
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73497763
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69926972
34ZNF274_21170338_ChIP-Seq_K562_Hela1.69858212
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68328253
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67444955
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65335303
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61071685
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61053807
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58300148
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54883613
42XRN2_22483619_ChIP-Seq_HELA_Human1.54778004
43TTF2_22483619_ChIP-Seq_HELA_Human1.51884158
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.48627395
45CIITA_25753668_ChIP-Seq_RAJI_Human1.47925693
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47497635
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45342904
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44579122
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43013665
50MYB_26560356_Chip-Seq_TH2_Human1.42819173
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.41290505
52IGF1R_20145208_ChIP-Seq_DFB_Human1.41176548
53SPI1_23547873_ChIP-Seq_NB4_Human1.36187994
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35240508
55MYC_18940864_ChIP-ChIP_HL60_Human1.31514183
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30751328
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28324500
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27702891
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20094097
60FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19763378
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19751809
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18755930
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.18059376
64TP53_22573176_ChIP-Seq_HFKS_Human1.18014734
65GATA3_26560356_Chip-Seq_TH2_Human1.17003147
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16067733
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15616446
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.15247327
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14174523
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12907153
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07686022
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06730134
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04402449
74BCL6_27268052_Chip-Seq_Bcells_Human1.04218067
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00885232
76VDR_22108803_ChIP-Seq_LS180_Human0.97928645
77ELF1_20517297_ChIP-Seq_JURKAT_Human0.93642184
78KDM5A_27292631_Chip-Seq_BREAST_Human0.93471546
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92298280
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91862623
81AR_20517297_ChIP-Seq_VCAP_Human0.90277128
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90064289
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89986936
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.89122835
85GATA3_27048872_Chip-Seq_THYMUS_Human0.89092663
86NANOG_20526341_ChIP-Seq_ESCs_Human0.86538487
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86125159
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85631770
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84963635
90E2F7_22180533_ChIP-Seq_HELA_Human0.84270910
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84072798
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.84072798
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.83327972
94MYB_26560356_Chip-Seq_TH1_Human0.81554741
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81057515
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80162743
97TAF2_19829295_ChIP-Seq_ESCs_Human0.79666120
98P300_27268052_Chip-Seq_Bcells_Human0.79556367
99NCOR_22424771_ChIP-Seq_293T_Human0.79204506
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79026186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.77330983
2MP0001835_abnormal_antigen_presentation3.73761992
3MP0009785_altered_susceptibility_to3.11650920
4MP0003806_abnormal_nucleotide_metabolis2.78585874
5MP0004147_increased_porphyrin_level2.56451778
6MP0008875_abnormal_xenobiotic_pharmacok2.47262625
7MP0002148_abnormal_hypersensitivity_rea2.44947859
8MP0009333_abnormal_splenocyte_physiolog2.41818561
9MP0006072_abnormal_retinal_apoptosis2.39637225
10MP0001800_abnormal_humoral_immune2.36114870
11MP0005000_abnormal_immune_tolerance2.26048133
12MP0001873_stomach_inflammation2.24072732
13MP0008058_abnormal_DNA_repair2.15199710
14MP0003763_abnormal_thymus_physiology2.13595432
15MP0006082_CNS_inflammation2.11956078
16MP0009764_decreased_sensitivity_to2.08797028
17MP0003724_increased_susceptibility_to2.03213012
18MP0002723_abnormal_immune_serum2.01786412
19MP0001790_abnormal_immune_system1.96788001
20MP0005387_immune_system_phenotype1.96788001
21MP0003436_decreased_susceptibility_to1.96371113
22MP0003786_premature_aging1.95151406
23MP0005025_abnormal_response_to1.90400677
24MP0002420_abnormal_adaptive_immunity1.89206373
25MP0003186_abnormal_redox_activity1.85797030
26MP0001819_abnormal_immune_cell1.85518443
27MP0002452_abnormal_antigen_presenting1.83961659
28MP0002837_dystrophic_cardiac_calcinosis1.82356287
29MP0000685_abnormal_immune_system1.81066527
30MP0002277_abnormal_respiratory_mucosa1.72543078
31MP0001853_heart_inflammation1.70354468
32MP0003866_abnormal_defecation1.64318152
33MP0002166_altered_tumor_susceptibility1.58427735
34MP0003646_muscle_fatigue1.53059649
35MP0006036_abnormal_mitochondrial_physio1.51867304
36MP0010155_abnormal_intestine_physiology1.51340571
37MP0002006_tumorigenesis1.45914147
38MP0008872_abnormal_physiological_respon1.44656068
39MP0002419_abnormal_innate_immunity1.41458229
40MP0002102_abnormal_ear_morphology1.41373886
41MP0001845_abnormal_inflammatory_respons1.40669886
42MP0000716_abnormal_immune_system1.39567486
43MP0005645_abnormal_hypothalamus_physiol1.38348710
44MP0003693_abnormal_embryo_hatching1.37826315
45MP0002163_abnormal_gland_morphology1.37502034
46MP0001986_abnormal_taste_sensitivity1.37280109
47MP0002398_abnormal_bone_marrow1.32113658
48MP0008789_abnormal_olfactory_epithelium1.30465158
49MP0001905_abnormal_dopamine_level1.30368077
50MP0001529_abnormal_vocalization1.30342514
51MP0008469_abnormal_protein_level1.29004479
52MP0001919_abnormal_reproductive_system1.25388355
53MP0006035_abnormal_mitochondrial_morpho1.23862394
54MP0010094_abnormal_chromosome_stability1.22641466
55MP0000689_abnormal_spleen_morphology1.20912271
56MP0002736_abnormal_nociception_after1.20586373
57MP0005253_abnormal_eye_physiology1.17967667
58MP0005360_urolithiasis1.17464532
59MP0000372_irregular_coat_pigmentation1.17372884
60MP0002429_abnormal_blood_cell1.16765866
61MP0004782_abnormal_surfactant_physiolog1.14608053
62MP0002722_abnormal_immune_system1.13182156
63MP0001968_abnormal_touch/_nociception1.12685464
64MP0002405_respiratory_system_inflammati1.12402304
65MP0000465_gastrointestinal_hemorrhage1.10707378
66MP0001764_abnormal_homeostasis1.06682701
67MP0005075_abnormal_melanosome_morpholog1.05372905
68MP0000703_abnormal_thymus_morphology1.03799272
69MP0005389_reproductive_system_phenotype1.02417598
70MP0008877_abnormal_DNA_methylation1.02118900
71MP0002095_abnormal_skin_pigmentation1.01951863
72MP0005084_abnormal_gallbladder_morpholo1.01441170
73MP0001542_abnormal_bone_strength0.98925654
74MP0009763_increased_sensitivity_to0.95484571
75MP0004142_abnormal_muscle_tone0.95034557
76MP0004145_abnormal_muscle_electrophysio0.93002055
77MP0005551_abnormal_eye_electrophysiolog0.89680049
78MP0005410_abnormal_fertilization0.88342221
79MP0002933_joint_inflammation0.87229942
80MP0005636_abnormal_mineral_homeostasis0.86568770
81MP0008873_increased_physiological_sensi0.84859061
82MP0002019_abnormal_tumor_incidence0.84135460
83MP0009379_abnormal_foot_pigmentation0.81194642
84MP0005319_abnormal_enzyme/_coenzyme0.80818618
85MP0002234_abnormal_pharynx_morphology0.80338415
86MP0006292_abnormal_olfactory_placode0.78206570
87MP0005584_abnormal_enzyme/coenzyme_acti0.77856642
88MP0005332_abnormal_amino_acid0.77725728
89MP0003448_altered_tumor_morphology0.77266063
90MP0005646_abnormal_pituitary_gland0.76167164
91MP0005394_taste/olfaction_phenotype0.75850736
92MP0005499_abnormal_olfactory_system0.75850736
93MP0008007_abnormal_cellular_replicative0.75229768
94MP0003718_maternal_effect0.74118421
95MP0009697_abnormal_copulation0.73024253
96MP0009765_abnormal_xenobiotic_induced0.72457363
97MP0002693_abnormal_pancreas_physiology0.69191689
98MP0002876_abnormal_thyroid_physiology0.67713534
99MP0001533_abnormal_skeleton_physiology0.67508519
100MP0008995_early_reproductive_senescence0.67425588

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.53770031
2Mitochondrial inheritance (HP:0001427)4.46962814
3Abnormal mitochondria in muscle tissue (HP:0008316)4.28016231
4Increased CSF lactate (HP:0002490)4.06174718
5Hepatocellular necrosis (HP:0001404)4.00302783
6Acute encephalopathy (HP:0006846)3.93829002
7Increased hepatocellular lipid droplets (HP:0006565)3.83942289
83-Methylglutaconic aciduria (HP:0003535)3.72704647
9Progressive macrocephaly (HP:0004481)3.71213895
10Elevated erythrocyte sedimentation rate (HP:0003565)3.70480739
11Lipid accumulation in hepatocytes (HP:0006561)3.58077037
12Increased intramyocellular lipid droplets (HP:0012240)3.56482680
13Hepatic necrosis (HP:0002605)3.52659221
14Abnormality of alanine metabolism (HP:0010916)3.36108361
15Hyperalaninemia (HP:0003348)3.36108361
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.36108361
17Increased serum lactate (HP:0002151)3.32098932
18IgG deficiency (HP:0004315)3.31579229
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.31441503
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.31441503
21Aplastic anemia (HP:0001915)3.21507139
22Lactic acidosis (HP:0003128)3.18091435
23Cerebral edema (HP:0002181)3.16262213
24Renal Fanconi syndrome (HP:0001994)3.07673105
25Increased muscle lipid content (HP:0009058)3.05098153
26Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03267751
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02086878
28Stomatitis (HP:0010280)2.81729344
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76072898
30Exertional dyspnea (HP:0002875)2.70106335
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56062304
32Optic disc pallor (HP:0000543)2.51328527
33Abnormal glycosylation (HP:0012345)2.50542687
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50542687
35Abnormal protein N-linked glycosylation (HP:0012347)2.50542687
36Abnormal protein glycosylation (HP:0012346)2.50542687
37Severe combined immunodeficiency (HP:0004430)2.50239162
38Abnormality of midbrain morphology (HP:0002418)2.49574126
39Molar tooth sign on MRI (HP:0002419)2.49574126
40Type I transferrin isoform profile (HP:0003642)2.48942058
41T lymphocytopenia (HP:0005403)2.47324230
42Abnormality of T cell number (HP:0011839)2.43176805
43Exercise intolerance (HP:0003546)2.42529523
44Pancreatic cysts (HP:0001737)2.42391877
45Microretrognathia (HP:0000308)2.41828591
46Abnormal rod and cone electroretinograms (HP:0008323)2.41707605
47Constricted visual fields (HP:0001133)2.41627148
48Abnormality of T cells (HP:0002843)2.41473550
49Hypoproteinemia (HP:0003075)2.39116614
50Abolished electroretinogram (ERG) (HP:0000550)2.36906741
51Pancytopenia (HP:0001876)2.29450906
52Respiratory failure (HP:0002878)2.28978332
53Abnormality of the prostate (HP:0008775)2.28556101
54Lethargy (HP:0001254)2.26520358
55Increased IgM level (HP:0003496)2.18347769
56Chronic diarrhea (HP:0002028)2.16770955
57Progressive microcephaly (HP:0000253)2.10160559
58Aplasia/hypoplasia of the uterus (HP:0008684)2.02917883
59True hermaphroditism (HP:0010459)2.00199784
60Abnormality of T cell physiology (HP:0011840)1.98101436
61Leukodystrophy (HP:0002415)1.97337213
62Generalized aminoaciduria (HP:0002909)1.96796679
63Recurrent cutaneous fungal infections (HP:0011370)1.95177024
64Chronic mucocutaneous candidiasis (HP:0002728)1.95177024
65IgM deficiency (HP:0002850)1.94911496
66Methylmalonic aciduria (HP:0012120)1.94388974
67Congenital, generalized hypertrichosis (HP:0004540)1.93918786
68Congenital stationary night blindness (HP:0007642)1.92715902
69Combined immunodeficiency (HP:0005387)1.92396717
70Atrophy/Degeneration involving motor neurons (HP:0007373)1.91929112
71Abnormality of eosinophils (HP:0001879)1.90557286
72Encephalitis (HP:0002383)1.90516396
73Pancreatic fibrosis (HP:0100732)1.89314051
74CNS demyelination (HP:0007305)1.87531919
75Colon cancer (HP:0003003)1.87291496
76Attenuation of retinal blood vessels (HP:0007843)1.86655443
77Amyotrophic lateral sclerosis (HP:0007354)1.83634760
78Type 2 muscle fiber atrophy (HP:0003554)1.83183663
79Respiratory difficulties (HP:0002880)1.82274668
80Myositis (HP:0100614)1.80892689
81Autoimmune hemolytic anemia (HP:0001890)1.80341550
82Glycosuria (HP:0003076)1.80150261
83Abnormality of urine glucose concentration (HP:0011016)1.80150261
84Degeneration of anterior horn cells (HP:0002398)1.79755623
85Abnormality of the anterior horn cell (HP:0006802)1.79755623
86Abnormality of serum amino acid levels (HP:0003112)1.78718995
87Emotional lability (HP:0000712)1.77095627
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.76285729
89Abnormal biliary tract physiology (HP:0012439)1.76034213
90Bile duct proliferation (HP:0001408)1.76034213
91Abnormality of renal resorption (HP:0011038)1.74852824
92Methylmalonic acidemia (HP:0002912)1.72378644
93Dicarboxylic aciduria (HP:0003215)1.71384983
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71384983
95Sclerocornea (HP:0000647)1.69515993
96Muscle fiber atrophy (HP:0100295)1.69318836
97Medial flaring of the eyebrow (HP:0010747)1.67960309
98Microvesicular hepatic steatosis (HP:0001414)1.67487175
99Parakeratosis (HP:0001036)1.65881094
100Pancreatitis (HP:0001733)1.65399936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.16461316
2TESK23.68905780
3KDR3.47632832
4VRK23.41930019
5BCKDK2.71755340
6CDK192.47708947
7MAP4K22.17761572
8BUB12.07914465
9SRPK11.97393638
10LIMK11.89282466
11TRIM281.89262362
12EIF2AK31.87297811
13MAP4K11.83207635
14NUAK11.77303498
15ZAK1.77086541
16TESK11.75958240
17MAP3K121.73422251
18EIF2AK11.72571116
19STK161.70395376
20CSNK1G31.59424150
21ADRBK21.57730810
22BCR1.54734400
23RPS6KA41.42682370
24NEK11.36678126
25CSNK1A1L1.36080616
26VRK11.34982662
27PIM21.34487849
28WNK31.29748351
29BMPR21.25512174
30MST41.23975140
31NME21.23968742
32TIE11.20999996
33WNK41.20914098
34ERBB31.17123428
35MAP2K71.14979422
36CSNK1G21.09758271
37DYRK21.09051608
38TLK11.06304973
39ITK1.05843067
40GRK11.04962713
41IKBKB1.04049178
42FES1.00902182
43DAPK11.00884722
44CSNK1G10.99442763
45IRAK40.97497524
46SYK0.90931441
47TAOK30.89624855
48CAMKK20.89212502
49MUSK0.88243475
50GRK60.86053672
51BMPR1B0.85628749
52RPS6KA50.85192503
53OXSR10.83795876
54IKBKE0.83461856
55PLK40.80489828
56LCK0.79598395
57TEC0.79466626
58MAP3K110.78533224
59GRK70.76190579
60LYN0.74915401
61EIF2AK20.73425532
62CSF1R0.72122445
63SCYL20.71247290
64INSRR0.68586004
65KIT0.65933024
66BTK0.65602828
67ZAP700.64470348
68TBK10.59025188
69ATR0.58990840
70STK390.58922692
71MATK0.57954184
72JAK30.56943567
73TSSK60.55537708
74PRKCQ0.55287111
75PLK30.54178855
76NME10.52829725
77CSK0.52712296
78MAP3K40.52472453
79PASK0.49866481
80CSNK2A10.48152226
81ADRBK10.46384543
82FRK0.45950222
83RIPK40.45481078
84CDK80.45197633
85MYLK0.44051143
86TAF10.43676714
87AURKA0.43380381
88MAP3K50.43270120
89AURKB0.41092044
90PAK10.39665747
91CDC70.38991335
92CSNK1A10.37964272
93ARAF0.37716508
94CSNK2A20.36708547
95MAP3K140.35792694
96FLT30.34885052
97MAPKAPK50.33737928
98DAPK30.32427986
99TNK20.32384168
100PLK10.31633269

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37938595
2Oxidative phosphorylation_Homo sapiens_hsa001903.50359252
3Allograft rejection_Homo sapiens_hsa053302.90526199
4Parkinsons disease_Homo sapiens_hsa050122.86311822
5Autoimmune thyroid disease_Homo sapiens_hsa053202.78643352
6Graft-versus-host disease_Homo sapiens_hsa053322.75351095
7Asthma_Homo sapiens_hsa053102.75002752
8Ribosome_Homo sapiens_hsa030102.49621845
9Caffeine metabolism_Homo sapiens_hsa002322.39651207
10Protein export_Homo sapiens_hsa030602.37155661
11Primary immunodeficiency_Homo sapiens_hsa053402.32174476
12Type I diabetes mellitus_Homo sapiens_hsa049402.24874417
13RNA polymerase_Homo sapiens_hsa030202.21297545
14Antigen processing and presentation_Homo sapiens_hsa046122.13471656
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.08507862
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05706971
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87836621
18Huntingtons disease_Homo sapiens_hsa050161.82125575
19Alzheimers disease_Homo sapiens_hsa050101.77276525
20DNA replication_Homo sapiens_hsa030301.74855687
21Rheumatoid arthritis_Homo sapiens_hsa053231.73462210
22Mismatch repair_Homo sapiens_hsa034301.71542277
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65446858
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60303158
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53694258
26Homologous recombination_Homo sapiens_hsa034401.46948269
27Pyrimidine metabolism_Homo sapiens_hsa002401.35201034
28Spliceosome_Homo sapiens_hsa030401.32300444
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29833460
30Viral myocarditis_Homo sapiens_hsa054161.25123746
31One carbon pool by folate_Homo sapiens_hsa006701.24204740
32Hematopoietic cell lineage_Homo sapiens_hsa046401.23758253
33Base excision repair_Homo sapiens_hsa034101.22006171
34Sulfur metabolism_Homo sapiens_hsa009201.15802046
35Basal transcription factors_Homo sapiens_hsa030221.13031450
36Nucleotide excision repair_Homo sapiens_hsa034201.12958753
37Collecting duct acid secretion_Homo sapiens_hsa049661.06965331
38RNA degradation_Homo sapiens_hsa030181.06695548
39Fanconi anemia pathway_Homo sapiens_hsa034601.03077849
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00742115
41Cardiac muscle contraction_Homo sapiens_hsa042600.96663838
42RNA transport_Homo sapiens_hsa030130.96189867
43Regulation of autophagy_Homo sapiens_hsa041400.92317324
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84461188
45Purine metabolism_Homo sapiens_hsa002300.82483748
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81859742
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80493274
48Non-homologous end-joining_Homo sapiens_hsa034500.79646650
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79078037
50Phototransduction_Homo sapiens_hsa047440.77703185
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76045851
52Shigellosis_Homo sapiens_hsa051310.75277313
53Herpes simplex infection_Homo sapiens_hsa051680.73974472
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.70278360
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70180649
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70135843
57Leishmaniasis_Homo sapiens_hsa051400.69540484
58Peroxisome_Homo sapiens_hsa041460.68540114
59Salmonella infection_Homo sapiens_hsa051320.67742173
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66658590
61Staphylococcus aureus infection_Homo sapiens_hsa051500.65185670
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.64489952
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63364582
64Fatty acid elongation_Homo sapiens_hsa000620.62436637
65Linoleic acid metabolism_Homo sapiens_hsa005910.62302070
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62078203
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61924732
68Epstein-Barr virus infection_Homo sapiens_hsa051690.61786859
69Sulfur relay system_Homo sapiens_hsa041220.61649405
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.60673633
71Propanoate metabolism_Homo sapiens_hsa006400.60038185
72Metabolic pathways_Homo sapiens_hsa011000.58457305
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58373339
74T cell receptor signaling pathway_Homo sapiens_hsa046600.55120998
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54606859
76Measles_Homo sapiens_hsa051620.53610286
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53496169
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49377239
79Nitrogen metabolism_Homo sapiens_hsa009100.45364091
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44816775
81Legionellosis_Homo sapiens_hsa051340.43752345
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42959798
83Systemic lupus erythematosus_Homo sapiens_hsa053220.39220455
84Butanoate metabolism_Homo sapiens_hsa006500.39217753
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38655796
86Tryptophan metabolism_Homo sapiens_hsa003800.37619203
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37038244
88Phagosome_Homo sapiens_hsa041450.36308669
89Chemical carcinogenesis_Homo sapiens_hsa052040.34851424
90Vibrio cholerae infection_Homo sapiens_hsa051100.33741334
91Steroid biosynthesis_Homo sapiens_hsa001000.33387348
92Glutathione metabolism_Homo sapiens_hsa004800.32757900
93Arachidonic acid metabolism_Homo sapiens_hsa005900.32195031
94Biosynthesis of amino acids_Homo sapiens_hsa012300.30554425
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.29410151
96Tuberculosis_Homo sapiens_hsa051520.26842043
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.25192285
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24057527
99Carbon metabolism_Homo sapiens_hsa012000.24028453
100Selenocompound metabolism_Homo sapiens_hsa004500.22926307

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