Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 5.96009618 |
2 | cytidine metabolic process (GO:0046087) | 4.72178316 |
3 | cytidine catabolic process (GO:0006216) | 4.72178316 |
4 | cytidine deamination (GO:0009972) | 4.72178316 |
5 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.69282350 |
6 | ATP synthesis coupled proton transport (GO:0015986) | 4.23414792 |
7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.23414792 |
8 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.22645009 |
9 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.17141884 |
10 | proteasome assembly (GO:0043248) | 4.11594070 |
11 | iron-sulfur cluster assembly (GO:0016226) | 3.95766584 |
12 | metallo-sulfur cluster assembly (GO:0031163) | 3.95766584 |
13 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.80287873 |
14 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.80287873 |
15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.71380677 |
16 | positive regulation of T cell apoptotic process (GO:0070234) | 3.67901024 |
17 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.63830848 |
18 | chaperone-mediated protein transport (GO:0072321) | 3.58714271 |
19 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.56078527 |
20 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.51647146 |
21 | protein neddylation (GO:0045116) | 3.48580255 |
22 | protein complex biogenesis (GO:0070271) | 3.42553330 |
23 | respiratory electron transport chain (GO:0022904) | 3.41645478 |
24 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.36841362 |
25 | electron transport chain (GO:0022900) | 3.35339516 |
26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.32811269 |
27 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.31952531 |
28 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.30104866 |
29 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.27514601 |
30 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.23357523 |
31 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.23021469 |
32 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.23021469 |
33 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.23021469 |
34 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.21457225 |
35 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.21457225 |
36 | negative regulation of ligase activity (GO:0051352) | 3.20489498 |
37 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.20489498 |
38 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.17335689 |
39 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.15242619 |
40 | sequestering of actin monomers (GO:0042989) | 3.12724616 |
41 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.12543751 |
42 | ribosomal small subunit assembly (GO:0000028) | 3.11411290 |
43 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.09739961 |
44 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.09739961 |
45 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.09189370 |
46 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.08691196 |
47 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.07352544 |
48 | protein deneddylation (GO:0000338) | 3.04841411 |
49 | regulation of cellular respiration (GO:0043457) | 3.03121190 |
50 | positive regulation of lymphocyte apoptotic process (GO:0070230) | 3.03021514 |
51 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.01777137 |
52 | NADH dehydrogenase complex assembly (GO:0010257) | 3.01777137 |
53 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.01777137 |
54 | cytochrome complex assembly (GO:0017004) | 2.98082067 |
55 | respiratory chain complex IV assembly (GO:0008535) | 2.96905499 |
56 | peptidyl-histidine modification (GO:0018202) | 2.96568124 |
57 | actin nucleation (GO:0045010) | 2.93754108 |
58 | cullin deneddylation (GO:0010388) | 2.93465305 |
59 | response to interferon-beta (GO:0035456) | 2.90649712 |
60 | platelet dense granule organization (GO:0060155) | 2.90451931 |
61 | oxidative phosphorylation (GO:0006119) | 2.87398123 |
62 | regulation of regulatory T cell differentiation (GO:0045589) | 2.87020018 |
63 | ubiquinone biosynthetic process (GO:0006744) | 2.85432454 |
64 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.83672082 |
65 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.82341248 |
66 | termination of RNA polymerase III transcription (GO:0006386) | 2.82341248 |
67 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.80177699 |
68 | regulation of chronic inflammatory response (GO:0002676) | 2.79485532 |
69 | mannosylation (GO:0097502) | 2.79414627 |
70 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.78542481 |
71 | protein-cofactor linkage (GO:0018065) | 2.77255278 |
72 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.76732739 |
73 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.75097668 |
74 | base-excision repair, AP site formation (GO:0006285) | 2.73941677 |
75 | cellular response to interferon-beta (GO:0035458) | 2.73073017 |
76 | positive regulation of ligase activity (GO:0051351) | 2.72957134 |
77 | protein targeting to mitochondrion (GO:0006626) | 2.72682684 |
78 | positive regulation of interleukin-8 secretion (GO:2000484) | 2.71943354 |
79 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.71097847 |
80 | hydrogen ion transmembrane transport (GO:1902600) | 2.70514779 |
81 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.70307620 |
82 | L-methionine biosynthetic process (GO:0071265) | 2.70231620 |
83 | amino acid salvage (GO:0043102) | 2.70231620 |
84 | L-methionine salvage (GO:0071267) | 2.70231620 |
85 | rRNA modification (GO:0000154) | 2.69642297 |
86 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.65633171 |
87 | GPI anchor biosynthetic process (GO:0006506) | 2.64419333 |
88 | regulation of T cell apoptotic process (GO:0070232) | 2.63829095 |
89 | deoxyribonucleotide catabolic process (GO:0009264) | 2.63049589 |
90 | ubiquinone metabolic process (GO:0006743) | 2.62797708 |
91 | protein localization to mitochondrion (GO:0070585) | 2.61290490 |
92 | establishment of protein localization to mitochondrion (GO:0072655) | 2.61200980 |
93 | GPI anchor metabolic process (GO:0006505) | 2.58977549 |
94 | proton transport (GO:0015992) | 2.58691177 |
95 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 2.58421144 |
96 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.57421754 |
97 | GDP-mannose metabolic process (GO:0019673) | 2.54266498 |
98 | deoxyribose phosphate catabolic process (GO:0046386) | 2.54047315 |
99 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.53902412 |
100 | regulation of cellular amine metabolic process (GO:0033238) | 2.53641134 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.48126728 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.38637368 |
3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.33766370 |
4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.31743920 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.82972411 |
6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.80842974 |
7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.80173724 |
8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.45556524 |
9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.10781231 |
10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.97309106 |
11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.88525011 |
12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.77532019 |
13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.64576369 |
14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.57889201 |
15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.51289631 |
16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.47483203 |
17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.45622024 |
18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.36100755 |
19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.30945334 |
20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.19758269 |
21 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.05351361 |
22 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.05219241 |
23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.04855137 |
24 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.03328724 |
25 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.99358352 |
26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.98366733 |
27 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.92147463 |
28 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.90651391 |
29 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.88550999 |
30 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.81700312 |
31 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.81644253 |
32 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.73497763 |
33 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.69926972 |
34 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.69858212 |
35 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.68328253 |
36 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67444955 |
37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.65335303 |
38 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.61071685 |
39 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.61053807 |
40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.58300148 |
41 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.54883613 |
42 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.54778004 |
43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.51884158 |
44 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.48627395 |
45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.47925693 |
46 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.47497635 |
47 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.45342904 |
48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44579122 |
49 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.43013665 |
50 | MYB_26560356_Chip-Seq_TH2_Human | 1.42819173 |
51 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.41290505 |
52 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.41176548 |
53 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.36187994 |
54 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.35240508 |
55 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.31514183 |
56 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.30751328 |
57 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.28324500 |
58 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.27702891 |
59 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20094097 |
60 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.19763378 |
61 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.19751809 |
62 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.18755930 |
63 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.18059376 |
64 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.18014734 |
65 | GATA3_26560356_Chip-Seq_TH2_Human | 1.17003147 |
66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16067733 |
67 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.15616446 |
68 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.15247327 |
69 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.14174523 |
70 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12907153 |
71 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.07686022 |
72 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06730134 |
73 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.04402449 |
74 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.04218067 |
75 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.00885232 |
76 | VDR_22108803_ChIP-Seq_LS180_Human | 0.97928645 |
77 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93642184 |
78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.93471546 |
79 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92298280 |
80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91862623 |
81 | AR_20517297_ChIP-Seq_VCAP_Human | 0.90277128 |
82 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.90064289 |
83 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.89986936 |
84 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89122835 |
85 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.89092663 |
86 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.86538487 |
87 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.86125159 |
88 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.85631770 |
89 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.84963635 |
90 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.84270910 |
91 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.84072798 |
92 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.84072798 |
93 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83327972 |
94 | MYB_26560356_Chip-Seq_TH1_Human | 0.81554741 |
95 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.81057515 |
96 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.80162743 |
97 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.79666120 |
98 | P300_27268052_Chip-Seq_Bcells_Human | 0.79556367 |
99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.79204506 |
100 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.79026186 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005671_abnormal_response_to | 4.77330983 |
2 | MP0001835_abnormal_antigen_presentation | 3.73761992 |
3 | MP0009785_altered_susceptibility_to | 3.11650920 |
4 | MP0003806_abnormal_nucleotide_metabolis | 2.78585874 |
5 | MP0004147_increased_porphyrin_level | 2.56451778 |
6 | MP0008875_abnormal_xenobiotic_pharmacok | 2.47262625 |
7 | MP0002148_abnormal_hypersensitivity_rea | 2.44947859 |
8 | MP0009333_abnormal_splenocyte_physiolog | 2.41818561 |
9 | MP0006072_abnormal_retinal_apoptosis | 2.39637225 |
10 | MP0001800_abnormal_humoral_immune | 2.36114870 |
11 | MP0005000_abnormal_immune_tolerance | 2.26048133 |
12 | MP0001873_stomach_inflammation | 2.24072732 |
13 | MP0008058_abnormal_DNA_repair | 2.15199710 |
14 | MP0003763_abnormal_thymus_physiology | 2.13595432 |
15 | MP0006082_CNS_inflammation | 2.11956078 |
16 | MP0009764_decreased_sensitivity_to | 2.08797028 |
17 | MP0003724_increased_susceptibility_to | 2.03213012 |
18 | MP0002723_abnormal_immune_serum | 2.01786412 |
19 | MP0001790_abnormal_immune_system | 1.96788001 |
20 | MP0005387_immune_system_phenotype | 1.96788001 |
21 | MP0003436_decreased_susceptibility_to | 1.96371113 |
22 | MP0003786_premature_aging | 1.95151406 |
23 | MP0005025_abnormal_response_to | 1.90400677 |
24 | MP0002420_abnormal_adaptive_immunity | 1.89206373 |
25 | MP0003186_abnormal_redox_activity | 1.85797030 |
26 | MP0001819_abnormal_immune_cell | 1.85518443 |
27 | MP0002452_abnormal_antigen_presenting | 1.83961659 |
28 | MP0002837_dystrophic_cardiac_calcinosis | 1.82356287 |
29 | MP0000685_abnormal_immune_system | 1.81066527 |
30 | MP0002277_abnormal_respiratory_mucosa | 1.72543078 |
31 | MP0001853_heart_inflammation | 1.70354468 |
32 | MP0003866_abnormal_defecation | 1.64318152 |
33 | MP0002166_altered_tumor_susceptibility | 1.58427735 |
34 | MP0003646_muscle_fatigue | 1.53059649 |
35 | MP0006036_abnormal_mitochondrial_physio | 1.51867304 |
36 | MP0010155_abnormal_intestine_physiology | 1.51340571 |
37 | MP0002006_tumorigenesis | 1.45914147 |
38 | MP0008872_abnormal_physiological_respon | 1.44656068 |
39 | MP0002419_abnormal_innate_immunity | 1.41458229 |
40 | MP0002102_abnormal_ear_morphology | 1.41373886 |
41 | MP0001845_abnormal_inflammatory_respons | 1.40669886 |
42 | MP0000716_abnormal_immune_system | 1.39567486 |
43 | MP0005645_abnormal_hypothalamus_physiol | 1.38348710 |
44 | MP0003693_abnormal_embryo_hatching | 1.37826315 |
45 | MP0002163_abnormal_gland_morphology | 1.37502034 |
46 | MP0001986_abnormal_taste_sensitivity | 1.37280109 |
47 | MP0002398_abnormal_bone_marrow | 1.32113658 |
48 | MP0008789_abnormal_olfactory_epithelium | 1.30465158 |
49 | MP0001905_abnormal_dopamine_level | 1.30368077 |
50 | MP0001529_abnormal_vocalization | 1.30342514 |
51 | MP0008469_abnormal_protein_level | 1.29004479 |
52 | MP0001919_abnormal_reproductive_system | 1.25388355 |
53 | MP0006035_abnormal_mitochondrial_morpho | 1.23862394 |
54 | MP0010094_abnormal_chromosome_stability | 1.22641466 |
55 | MP0000689_abnormal_spleen_morphology | 1.20912271 |
56 | MP0002736_abnormal_nociception_after | 1.20586373 |
57 | MP0005253_abnormal_eye_physiology | 1.17967667 |
58 | MP0005360_urolithiasis | 1.17464532 |
59 | MP0000372_irregular_coat_pigmentation | 1.17372884 |
60 | MP0002429_abnormal_blood_cell | 1.16765866 |
61 | MP0004782_abnormal_surfactant_physiolog | 1.14608053 |
62 | MP0002722_abnormal_immune_system | 1.13182156 |
63 | MP0001968_abnormal_touch/_nociception | 1.12685464 |
64 | MP0002405_respiratory_system_inflammati | 1.12402304 |
65 | MP0000465_gastrointestinal_hemorrhage | 1.10707378 |
66 | MP0001764_abnormal_homeostasis | 1.06682701 |
67 | MP0005075_abnormal_melanosome_morpholog | 1.05372905 |
68 | MP0000703_abnormal_thymus_morphology | 1.03799272 |
69 | MP0005389_reproductive_system_phenotype | 1.02417598 |
70 | MP0008877_abnormal_DNA_methylation | 1.02118900 |
71 | MP0002095_abnormal_skin_pigmentation | 1.01951863 |
72 | MP0005084_abnormal_gallbladder_morpholo | 1.01441170 |
73 | MP0001542_abnormal_bone_strength | 0.98925654 |
74 | MP0009763_increased_sensitivity_to | 0.95484571 |
75 | MP0004142_abnormal_muscle_tone | 0.95034557 |
76 | MP0004145_abnormal_muscle_electrophysio | 0.93002055 |
77 | MP0005551_abnormal_eye_electrophysiolog | 0.89680049 |
78 | MP0005410_abnormal_fertilization | 0.88342221 |
79 | MP0002933_joint_inflammation | 0.87229942 |
80 | MP0005636_abnormal_mineral_homeostasis | 0.86568770 |
81 | MP0008873_increased_physiological_sensi | 0.84859061 |
82 | MP0002019_abnormal_tumor_incidence | 0.84135460 |
83 | MP0009379_abnormal_foot_pigmentation | 0.81194642 |
84 | MP0005319_abnormal_enzyme/_coenzyme | 0.80818618 |
85 | MP0002234_abnormal_pharynx_morphology | 0.80338415 |
86 | MP0006292_abnormal_olfactory_placode | 0.78206570 |
87 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.77856642 |
88 | MP0005332_abnormal_amino_acid | 0.77725728 |
89 | MP0003448_altered_tumor_morphology | 0.77266063 |
90 | MP0005646_abnormal_pituitary_gland | 0.76167164 |
91 | MP0005394_taste/olfaction_phenotype | 0.75850736 |
92 | MP0005499_abnormal_olfactory_system | 0.75850736 |
93 | MP0008007_abnormal_cellular_replicative | 0.75229768 |
94 | MP0003718_maternal_effect | 0.74118421 |
95 | MP0009697_abnormal_copulation | 0.73024253 |
96 | MP0009765_abnormal_xenobiotic_induced | 0.72457363 |
97 | MP0002693_abnormal_pancreas_physiology | 0.69191689 |
98 | MP0002876_abnormal_thyroid_physiology | 0.67713534 |
99 | MP0001533_abnormal_skeleton_physiology | 0.67508519 |
100 | MP0008995_early_reproductive_senescence | 0.67425588 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.53770031 |
2 | Mitochondrial inheritance (HP:0001427) | 4.46962814 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.28016231 |
4 | Increased CSF lactate (HP:0002490) | 4.06174718 |
5 | Hepatocellular necrosis (HP:0001404) | 4.00302783 |
6 | Acute encephalopathy (HP:0006846) | 3.93829002 |
7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.83942289 |
8 | 3-Methylglutaconic aciduria (HP:0003535) | 3.72704647 |
9 | Progressive macrocephaly (HP:0004481) | 3.71213895 |
10 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.70480739 |
11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.58077037 |
12 | Increased intramyocellular lipid droplets (HP:0012240) | 3.56482680 |
13 | Hepatic necrosis (HP:0002605) | 3.52659221 |
14 | Abnormality of alanine metabolism (HP:0010916) | 3.36108361 |
15 | Hyperalaninemia (HP:0003348) | 3.36108361 |
16 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.36108361 |
17 | Increased serum lactate (HP:0002151) | 3.32098932 |
18 | IgG deficiency (HP:0004315) | 3.31579229 |
19 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.31441503 |
20 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.31441503 |
21 | Aplastic anemia (HP:0001915) | 3.21507139 |
22 | Lactic acidosis (HP:0003128) | 3.18091435 |
23 | Cerebral edema (HP:0002181) | 3.16262213 |
24 | Renal Fanconi syndrome (HP:0001994) | 3.07673105 |
25 | Increased muscle lipid content (HP:0009058) | 3.05098153 |
26 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.03267751 |
27 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.02086878 |
28 | Stomatitis (HP:0010280) | 2.81729344 |
29 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.76072898 |
30 | Exertional dyspnea (HP:0002875) | 2.70106335 |
31 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.56062304 |
32 | Optic disc pallor (HP:0000543) | 2.51328527 |
33 | Abnormal glycosylation (HP:0012345) | 2.50542687 |
34 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.50542687 |
35 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.50542687 |
36 | Abnormal protein glycosylation (HP:0012346) | 2.50542687 |
37 | Severe combined immunodeficiency (HP:0004430) | 2.50239162 |
38 | Abnormality of midbrain morphology (HP:0002418) | 2.49574126 |
39 | Molar tooth sign on MRI (HP:0002419) | 2.49574126 |
40 | Type I transferrin isoform profile (HP:0003642) | 2.48942058 |
41 | T lymphocytopenia (HP:0005403) | 2.47324230 |
42 | Abnormality of T cell number (HP:0011839) | 2.43176805 |
43 | Exercise intolerance (HP:0003546) | 2.42529523 |
44 | Pancreatic cysts (HP:0001737) | 2.42391877 |
45 | Microretrognathia (HP:0000308) | 2.41828591 |
46 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.41707605 |
47 | Constricted visual fields (HP:0001133) | 2.41627148 |
48 | Abnormality of T cells (HP:0002843) | 2.41473550 |
49 | Hypoproteinemia (HP:0003075) | 2.39116614 |
50 | Abolished electroretinogram (ERG) (HP:0000550) | 2.36906741 |
51 | Pancytopenia (HP:0001876) | 2.29450906 |
52 | Respiratory failure (HP:0002878) | 2.28978332 |
53 | Abnormality of the prostate (HP:0008775) | 2.28556101 |
54 | Lethargy (HP:0001254) | 2.26520358 |
55 | Increased IgM level (HP:0003496) | 2.18347769 |
56 | Chronic diarrhea (HP:0002028) | 2.16770955 |
57 | Progressive microcephaly (HP:0000253) | 2.10160559 |
58 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.02917883 |
59 | True hermaphroditism (HP:0010459) | 2.00199784 |
60 | Abnormality of T cell physiology (HP:0011840) | 1.98101436 |
61 | Leukodystrophy (HP:0002415) | 1.97337213 |
62 | Generalized aminoaciduria (HP:0002909) | 1.96796679 |
63 | Recurrent cutaneous fungal infections (HP:0011370) | 1.95177024 |
64 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.95177024 |
65 | IgM deficiency (HP:0002850) | 1.94911496 |
66 | Methylmalonic aciduria (HP:0012120) | 1.94388974 |
67 | Congenital, generalized hypertrichosis (HP:0004540) | 1.93918786 |
68 | Congenital stationary night blindness (HP:0007642) | 1.92715902 |
69 | Combined immunodeficiency (HP:0005387) | 1.92396717 |
70 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.91929112 |
71 | Abnormality of eosinophils (HP:0001879) | 1.90557286 |
72 | Encephalitis (HP:0002383) | 1.90516396 |
73 | Pancreatic fibrosis (HP:0100732) | 1.89314051 |
74 | CNS demyelination (HP:0007305) | 1.87531919 |
75 | Colon cancer (HP:0003003) | 1.87291496 |
76 | Attenuation of retinal blood vessels (HP:0007843) | 1.86655443 |
77 | Amyotrophic lateral sclerosis (HP:0007354) | 1.83634760 |
78 | Type 2 muscle fiber atrophy (HP:0003554) | 1.83183663 |
79 | Respiratory difficulties (HP:0002880) | 1.82274668 |
80 | Myositis (HP:0100614) | 1.80892689 |
81 | Autoimmune hemolytic anemia (HP:0001890) | 1.80341550 |
82 | Glycosuria (HP:0003076) | 1.80150261 |
83 | Abnormality of urine glucose concentration (HP:0011016) | 1.80150261 |
84 | Degeneration of anterior horn cells (HP:0002398) | 1.79755623 |
85 | Abnormality of the anterior horn cell (HP:0006802) | 1.79755623 |
86 | Abnormality of serum amino acid levels (HP:0003112) | 1.78718995 |
87 | Emotional lability (HP:0000712) | 1.77095627 |
88 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.76285729 |
89 | Abnormal biliary tract physiology (HP:0012439) | 1.76034213 |
90 | Bile duct proliferation (HP:0001408) | 1.76034213 |
91 | Abnormality of renal resorption (HP:0011038) | 1.74852824 |
92 | Methylmalonic acidemia (HP:0002912) | 1.72378644 |
93 | Dicarboxylic aciduria (HP:0003215) | 1.71384983 |
94 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.71384983 |
95 | Sclerocornea (HP:0000647) | 1.69515993 |
96 | Muscle fiber atrophy (HP:0100295) | 1.69318836 |
97 | Medial flaring of the eyebrow (HP:0010747) | 1.67960309 |
98 | Microvesicular hepatic steatosis (HP:0001414) | 1.67487175 |
99 | Parakeratosis (HP:0001036) | 1.65881094 |
100 | Pancreatitis (HP:0001733) | 1.65399936 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TXK | 4.16461316 |
2 | TESK2 | 3.68905780 |
3 | KDR | 3.47632832 |
4 | VRK2 | 3.41930019 |
5 | BCKDK | 2.71755340 |
6 | CDK19 | 2.47708947 |
7 | MAP4K2 | 2.17761572 |
8 | BUB1 | 2.07914465 |
9 | SRPK1 | 1.97393638 |
10 | LIMK1 | 1.89282466 |
11 | TRIM28 | 1.89262362 |
12 | EIF2AK3 | 1.87297811 |
13 | MAP4K1 | 1.83207635 |
14 | NUAK1 | 1.77303498 |
15 | ZAK | 1.77086541 |
16 | TESK1 | 1.75958240 |
17 | MAP3K12 | 1.73422251 |
18 | EIF2AK1 | 1.72571116 |
19 | STK16 | 1.70395376 |
20 | CSNK1G3 | 1.59424150 |
21 | ADRBK2 | 1.57730810 |
22 | BCR | 1.54734400 |
23 | RPS6KA4 | 1.42682370 |
24 | NEK1 | 1.36678126 |
25 | CSNK1A1L | 1.36080616 |
26 | VRK1 | 1.34982662 |
27 | PIM2 | 1.34487849 |
28 | WNK3 | 1.29748351 |
29 | BMPR2 | 1.25512174 |
30 | MST4 | 1.23975140 |
31 | NME2 | 1.23968742 |
32 | TIE1 | 1.20999996 |
33 | WNK4 | 1.20914098 |
34 | ERBB3 | 1.17123428 |
35 | MAP2K7 | 1.14979422 |
36 | CSNK1G2 | 1.09758271 |
37 | DYRK2 | 1.09051608 |
38 | TLK1 | 1.06304973 |
39 | ITK | 1.05843067 |
40 | GRK1 | 1.04962713 |
41 | IKBKB | 1.04049178 |
42 | FES | 1.00902182 |
43 | DAPK1 | 1.00884722 |
44 | CSNK1G1 | 0.99442763 |
45 | IRAK4 | 0.97497524 |
46 | SYK | 0.90931441 |
47 | TAOK3 | 0.89624855 |
48 | CAMKK2 | 0.89212502 |
49 | MUSK | 0.88243475 |
50 | GRK6 | 0.86053672 |
51 | BMPR1B | 0.85628749 |
52 | RPS6KA5 | 0.85192503 |
53 | OXSR1 | 0.83795876 |
54 | IKBKE | 0.83461856 |
55 | PLK4 | 0.80489828 |
56 | LCK | 0.79598395 |
57 | TEC | 0.79466626 |
58 | MAP3K11 | 0.78533224 |
59 | GRK7 | 0.76190579 |
60 | LYN | 0.74915401 |
61 | EIF2AK2 | 0.73425532 |
62 | CSF1R | 0.72122445 |
63 | SCYL2 | 0.71247290 |
64 | INSRR | 0.68586004 |
65 | KIT | 0.65933024 |
66 | BTK | 0.65602828 |
67 | ZAP70 | 0.64470348 |
68 | TBK1 | 0.59025188 |
69 | ATR | 0.58990840 |
70 | STK39 | 0.58922692 |
71 | MATK | 0.57954184 |
72 | JAK3 | 0.56943567 |
73 | TSSK6 | 0.55537708 |
74 | PRKCQ | 0.55287111 |
75 | PLK3 | 0.54178855 |
76 | NME1 | 0.52829725 |
77 | CSK | 0.52712296 |
78 | MAP3K4 | 0.52472453 |
79 | PASK | 0.49866481 |
80 | CSNK2A1 | 0.48152226 |
81 | ADRBK1 | 0.46384543 |
82 | FRK | 0.45950222 |
83 | RIPK4 | 0.45481078 |
84 | CDK8 | 0.45197633 |
85 | MYLK | 0.44051143 |
86 | TAF1 | 0.43676714 |
87 | AURKA | 0.43380381 |
88 | MAP3K5 | 0.43270120 |
89 | AURKB | 0.41092044 |
90 | PAK1 | 0.39665747 |
91 | CDC7 | 0.38991335 |
92 | CSNK1A1 | 0.37964272 |
93 | ARAF | 0.37716508 |
94 | CSNK2A2 | 0.36708547 |
95 | MAP3K14 | 0.35792694 |
96 | FLT3 | 0.34885052 |
97 | MAPKAPK5 | 0.33737928 |
98 | DAPK3 | 0.32427986 |
99 | TNK2 | 0.32384168 |
100 | PLK1 | 0.31633269 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.37938595 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.50359252 |
3 | Allograft rejection_Homo sapiens_hsa05330 | 2.90526199 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.86311822 |
5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.78643352 |
6 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.75351095 |
7 | Asthma_Homo sapiens_hsa05310 | 2.75002752 |
8 | Ribosome_Homo sapiens_hsa03010 | 2.49621845 |
9 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.39651207 |
10 | Protein export_Homo sapiens_hsa03060 | 2.37155661 |
11 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.32174476 |
12 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.24874417 |
13 | RNA polymerase_Homo sapiens_hsa03020 | 2.21297545 |
14 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.13471656 |
15 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.08507862 |
16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.05706971 |
17 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.87836621 |
18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.82125575 |
19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.77276525 |
20 | DNA replication_Homo sapiens_hsa03030 | 1.74855687 |
21 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.73462210 |
22 | Mismatch repair_Homo sapiens_hsa03430 | 1.71542277 |
23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.65446858 |
24 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.60303158 |
25 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.53694258 |
26 | Homologous recombination_Homo sapiens_hsa03440 | 1.46948269 |
27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.35201034 |
28 | Spliceosome_Homo sapiens_hsa03040 | 1.32300444 |
29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.29833460 |
30 | Viral myocarditis_Homo sapiens_hsa05416 | 1.25123746 |
31 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.24204740 |
32 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.23758253 |
33 | Base excision repair_Homo sapiens_hsa03410 | 1.22006171 |
34 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.15802046 |
35 | Basal transcription factors_Homo sapiens_hsa03022 | 1.13031450 |
36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.12958753 |
37 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.06965331 |
38 | RNA degradation_Homo sapiens_hsa03018 | 1.06695548 |
39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.03077849 |
40 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.00742115 |
41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.96663838 |
42 | RNA transport_Homo sapiens_hsa03013 | 0.96189867 |
43 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.92317324 |
44 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.84461188 |
45 | Purine metabolism_Homo sapiens_hsa00230 | 0.82483748 |
46 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.81859742 |
47 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.80493274 |
48 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.79646650 |
49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.79078037 |
50 | Phototransduction_Homo sapiens_hsa04744 | 0.77703185 |
51 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.76045851 |
52 | Shigellosis_Homo sapiens_hsa05131 | 0.75277313 |
53 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.73974472 |
54 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.70278360 |
55 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.70180649 |
56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.70135843 |
57 | Leishmaniasis_Homo sapiens_hsa05140 | 0.69540484 |
58 | Peroxisome_Homo sapiens_hsa04146 | 0.68540114 |
59 | Salmonella infection_Homo sapiens_hsa05132 | 0.67742173 |
60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.66658590 |
61 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.65185670 |
62 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.64489952 |
63 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.63364582 |
64 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.62436637 |
65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.62302070 |
66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62078203 |
67 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.61924732 |
68 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.61786859 |
69 | Sulfur relay system_Homo sapiens_hsa04122 | 0.61649405 |
70 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.60673633 |
71 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.60038185 |
72 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58457305 |
73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58373339 |
74 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.55120998 |
75 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.54606859 |
76 | Measles_Homo sapiens_hsa05162 | 0.53610286 |
77 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.53496169 |
78 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.49377239 |
79 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.45364091 |
80 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.44816775 |
81 | Legionellosis_Homo sapiens_hsa05134 | 0.43752345 |
82 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.42959798 |
83 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39220455 |
84 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.39217753 |
85 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38655796 |
86 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.37619203 |
87 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.37038244 |
88 | Phagosome_Homo sapiens_hsa04145 | 0.36308669 |
89 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.34851424 |
90 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.33741334 |
91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.33387348 |
92 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.32757900 |
93 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.32195031 |
94 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.30554425 |
95 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.29410151 |
96 | Tuberculosis_Homo sapiens_hsa05152 | 0.26842043 |
97 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.25192285 |
98 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.24057527 |
99 | Carbon metabolism_Homo sapiens_hsa01200 | 0.24028453 |
100 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.22926307 |