PRDX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to nitrosative stress (GO:0051409)6.72394753
2xenobiotic catabolic process (GO:0042178)6.34817471
3sulfur amino acid catabolic process (GO:0000098)6.13241952
4ethanol oxidation (GO:0006069)5.91158039
5uronic acid metabolic process (GO:0006063)4.97329899
6glucuronate metabolic process (GO:0019585)4.97329899
7cellular glucuronidation (GO:0052695)4.84115219
8valine metabolic process (GO:0006573)4.80052702
9ribosomal small subunit assembly (GO:0000028)4.73257008
10viral transcription (GO:0019083)4.63517208
11ribosomal small subunit biogenesis (GO:0042274)4.59234592
12hormone catabolic process (GO:0042447)4.56098754
13translational termination (GO:0006415)4.52388550
14L-serine metabolic process (GO:0006563)4.44256553
15regulation of cholesterol biosynthetic process (GO:0045540)4.42268130
16primary alcohol catabolic process (GO:0034310)4.38448637
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33637224
18ethanol metabolic process (GO:0006067)4.32073336
19ribosomal large subunit biogenesis (GO:0042273)4.28158205
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26039566
21pyrimidine-containing compound transmembrane transport (GO:0072531)4.19756529
22cotranslational protein targeting to membrane (GO:0006613)4.17975957
23protein targeting to ER (GO:0045047)4.13433898
24establishment of integrated proviral latency (GO:0075713)4.11787472
25maturation of SSU-rRNA (GO:0030490)4.11631678
26formation of translation preinitiation complex (GO:0001731)4.03700514
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.99614307
28one-carbon compound transport (GO:0019755)3.97808790
29cysteine metabolic process (GO:0006534)3.94039258
30glutathione derivative biosynthetic process (GO:1901687)3.93854189
31glutathione derivative metabolic process (GO:1901685)3.93854189
32protein localization to endoplasmic reticulum (GO:0070972)3.92821393
33reverse cholesterol transport (GO:0043691)3.92530360
34translational elongation (GO:0006414)3.85931795
35serine family amino acid biosynthetic process (GO:0009070)3.78590451
36translational initiation (GO:0006413)3.74273810
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73085013
38regulation of cholesterol metabolic process (GO:0090181)3.67811110
39branched-chain amino acid catabolic process (GO:0009083)3.66349713
40low-density lipoprotein particle remodeling (GO:0034374)3.64423066
41high-density lipoprotein particle remodeling (GO:0034375)3.63967925
42alpha-linolenic acid metabolic process (GO:0036109)3.63516688
43nucleobase-containing small molecule interconversion (GO:0015949)3.58748618
44branching involved in prostate gland morphogenesis (GO:0060442)3.57848459
45cellular modified amino acid catabolic process (GO:0042219)3.56458991
46viral life cycle (GO:0019058)3.55948660
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55687719
48ATP synthesis coupled proton transport (GO:0015986)3.55687719
49aldehyde catabolic process (GO:0046185)3.55252650
50benzene-containing compound metabolic process (GO:0042537)3.55074837
51renal absorption (GO:0070293)3.52724231
52cellular protein complex disassembly (GO:0043624)3.52500911
53DNA strand elongation involved in DNA replication (GO:0006271)3.47853542
54proteasome assembly (GO:0043248)3.46561207
55peptide catabolic process (GO:0043171)3.46284406
56glutathione metabolic process (GO:0006749)3.45896787
57branched-chain amino acid metabolic process (GO:0009081)3.44541043
58L-ascorbic acid metabolic process (GO:0019852)3.41994697
59purine nucleobase biosynthetic process (GO:0009113)3.41552791
60oxidative phosphorylation (GO:0006119)3.38223785
61IMP biosynthetic process (GO:0006188)3.38136117
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36214738
63DNA strand elongation (GO:0022616)3.34394152
64ribonucleoprotein complex biogenesis (GO:0022613)3.31859506
65negative regulation of cholesterol transport (GO:0032375)3.30917992
66negative regulation of sterol transport (GO:0032372)3.30917992
67amino-acid betaine metabolic process (GO:0006577)3.29109149
68telomere maintenance via semi-conservative replication (GO:0032201)3.28798451
69L-phenylalanine metabolic process (GO:0006558)3.27621359
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27621359
71translation (GO:0006412)3.24392927
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23036256
73plasma lipoprotein particle remodeling (GO:0034369)3.22451019
74protein-lipid complex remodeling (GO:0034368)3.22451019
75macromolecular complex remodeling (GO:0034367)3.22451019
76vitamin transmembrane transport (GO:0035461)3.22090953
77IMP metabolic process (GO:0046040)3.21991043
78L-phenylalanine catabolic process (GO:0006559)3.19300751
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.19300751
80L-fucose catabolic process (GO:0042355)3.17742897
81fucose catabolic process (GO:0019317)3.17742897
82L-fucose metabolic process (GO:0042354)3.17742897
83regulation of translational fidelity (GO:0006450)3.17042807
84serine family amino acid metabolic process (GO:0009069)3.16813248
85carnitine metabolic process (GO:0009437)3.14447138
86establishment of viral latency (GO:0019043)3.12924641
87homocysteine metabolic process (GO:0050667)3.12346301
88protein complex disassembly (GO:0043241)3.11893539
89galactose metabolic process (GO:0006012)3.10630997
90lipid oxidation (GO:0034440)3.08942816
91protein maturation by protein folding (GO:0022417)3.08240088
92proline metabolic process (GO:0006560)3.07366564
93chaperone-mediated protein transport (GO:0072321)3.06518527
94cellular amino acid catabolic process (GO:0009063)3.06411208
95proline biosynthetic process (GO:0006561)3.06077966
96glycine metabolic process (GO:0006544)3.06042321
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05979043
98protein neddylation (GO:0045116)3.05637224
99DNA unwinding involved in DNA replication (GO:0006268)3.05420484
100CENP-A containing nucleosome assembly (GO:0034080)3.03194072
101protein targeting to membrane (GO:0006612)3.03193538
102mitotic metaphase plate congression (GO:0007080)3.02418057
103nucleobase biosynthetic process (GO:0046112)3.02316035
104tricarboxylic acid cycle (GO:0006099)3.01874937
105flavonoid metabolic process (GO:0009812)3.01559344
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01284547
107negative regulation of ligase activity (GO:0051352)3.01284547
108nucleotide-sugar biosynthetic process (GO:0009226)3.00664688
109fatty acid oxidation (GO:0019395)3.00059550
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99639445
111chromatin remodeling at centromere (GO:0031055)2.98922555
112serine family amino acid catabolic process (GO:0009071)2.97632099
113nucleotide transmembrane transport (GO:1901679)2.96301615
114macromolecular complex disassembly (GO:0032984)2.95811571
115short-chain fatty acid metabolic process (GO:0046459)2.94581833
116regulation of cholesterol esterification (GO:0010872)2.94579412
117establishment of protein localization to mitochondrial membrane (GO:0090151)2.91909522
118regulation of skeletal muscle contraction (GO:0014819)2.91863095
119ribosome assembly (GO:0042255)2.91667939
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91257601
121respiratory electron transport chain (GO:0022904)2.91069835
122fructose metabolic process (GO:0006000)2.90752380
123mitotic cell cycle arrest (GO:0071850)2.90430225
124lysine metabolic process (GO:0006553)2.90263535
125lysine catabolic process (GO:0006554)2.90263535
126regulation of mitochondrial translation (GO:0070129)2.88173955
127prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87630043
128mitotic chromosome condensation (GO:0007076)2.86696851
129bile acid biosynthetic process (GO:0006699)2.86275451
130sulfur amino acid metabolic process (GO:0000096)2.84849046
131very-low-density lipoprotein particle assembly (GO:0034379)2.83912787
132glyoxylate metabolic process (GO:0046487)2.83078954
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82700660
134protein localization to kinetochore (GO:0034501)2.82432828
135aromatic amino acid family catabolic process (GO:0009074)2.82351867
136galactose catabolic process (GO:0019388)2.82210262
137indole-containing compound catabolic process (GO:0042436)2.81527647
138indolalkylamine catabolic process (GO:0046218)2.81527647
139tryptophan catabolic process (GO:0006569)2.81527647
140electron transport chain (GO:0022900)2.81268294
141gap junction assembly (GO:0016264)2.80274560
1422-oxoglutarate metabolic process (GO:0006103)2.79665281
143positive regulation of steroid metabolic process (GO:0045940)2.78577340
144alpha-amino acid catabolic process (GO:1901606)2.77881503
145organic acid catabolic process (GO:0016054)2.76359051
146carboxylic acid catabolic process (GO:0046395)2.76359051
147fatty acid beta-oxidation (GO:0006635)2.76310509
148DNA replication checkpoint (GO:0000076)2.76021986
149nuclear pore complex assembly (GO:0051292)2.75635687
150positive regulation of triglyceride biosynthetic process (GO:0010867)2.74734671
151regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.74631472
152plasma lipoprotein particle organization (GO:0071827)2.73855335
153tRNA aminoacylation for protein translation (GO:0006418)2.72989436
154mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72912939
155polyketide metabolic process (GO:0030638)2.72847173
156doxorubicin metabolic process (GO:0044598)2.72847173
157daunorubicin metabolic process (GO:0044597)2.72847173
158NADPH regeneration (GO:0006740)2.72842521
159calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.72077995
160cellular component biogenesis (GO:0044085)2.71432707
161UDP-N-acetylglucosamine metabolic process (GO:0006047)2.70654730
162protein complex localization (GO:0031503)2.69610737
163folic acid-containing compound biosynthetic process (GO:0009396)2.69538722
164kynurenine metabolic process (GO:0070189)2.68617111
165Golgi transport vesicle coating (GO:0048200)2.67498929
166COPI coating of Golgi vesicle (GO:0048205)2.67498929
167regulation of cholesterol homeostasis (GO:2000188)2.66658411
168telomere maintenance via recombination (GO:0000722)2.66432032
169regulation of triglyceride catabolic process (GO:0010896)2.66295737
170xenobiotic metabolic process (GO:0006805)2.65800703
171amino acid activation (GO:0043038)2.64931517
172tRNA aminoacylation (GO:0043039)2.64931517
173mitotic sister chromatid segregation (GO:0000070)2.64875483
174pentose-phosphate shunt (GO:0006098)2.64564666
175tryptophan metabolic process (GO:0006568)2.64359353
176tetrahydrofolate metabolic process (GO:0046653)2.64148726
177protein targeting to mitochondrion (GO:0006626)2.63265040
178nuclear-transcribed mRNA catabolic process (GO:0000956)2.61225432
179NADH metabolic process (GO:0006734)2.60423319
180regulation of cellular amino acid metabolic process (GO:0006521)2.58862122
181positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58816589
182ribosome biogenesis (GO:0042254)2.58587320
183mitotic recombination (GO:0006312)2.55252587
184rRNA modification (GO:0000154)2.54749580
185aerobic respiration (GO:0009060)2.52788488
186protein localization to chromosome, centromeric region (GO:0071459)2.51081777
187DNA replication-independent nucleosome organization (GO:0034724)2.50726872
188DNA replication-independent nucleosome assembly (GO:0006336)2.50726872
189regulation of ubiquitin-protein transferase activity (GO:0051438)2.50682613
190cellular protein complex localization (GO:0034629)2.50556900
191heterochromatin organization (GO:0070828)2.49599337
192positive regulation of ligase activity (GO:0051351)2.47706219
193pteridine-containing compound biosynthetic process (GO:0042559)2.47367934
194purine nucleoside monophosphate biosynthetic process (GO:0009127)2.46850034
195purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.46850034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.74513444
2E2F7_22180533_ChIP-Seq_HELA_Human5.77955735
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.68609288
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.45903194
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.19749119
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.85695057
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.84958299
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.56393839
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.35429424
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.33837649
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14631684
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.79474816
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.75794727
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75173235
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70073502
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.68210854
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67309910
18CLOCK_20551151_ChIP-Seq_293T_Human2.43476118
19* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33150851
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26483576
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24295050
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.13072793
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11758071
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10099992
25ZNF263_19887448_ChIP-Seq_K562_Human2.08907624
26* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.05702267
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01462049
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00724321
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00108736
30TTF2_22483619_ChIP-Seq_HELA_Human1.93709945
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88940677
32ELK1_19687146_ChIP-ChIP_HELA_Human1.87929552
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86958079
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84558405
35AR_21909140_ChIP-Seq_LNCAP_Human1.78852459
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76245456
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71866767
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71764180
39GATA1_22025678_ChIP-Seq_K562_Human1.70972740
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66175076
41* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64612874
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.63091159
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61924750
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61497723
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.60481232
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58353067
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.57007288
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55328962
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53113943
50GABP_19822575_ChIP-Seq_HepG2_Human1.51624032
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50612407
52GATA4_25053715_ChIP-Seq_YYC3_Human1.49537406
53* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49092392
54FOXP3_21729870_ChIP-Seq_TREG_Human1.48586656
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47899497
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.46985498
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44971974
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44948290
59SOX2_20726797_ChIP-Seq_SW620_Human1.42857751
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41946204
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40924971
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.40341496
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39995195
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.39720212
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39155051
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38814908
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37309885
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34447552
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34317888
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29176283
71* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29158047
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28858420
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28487219
74* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.27437751
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.27119573
76* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26018830
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22651933
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21649911
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.21517440
80* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21101636
81* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19820895
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19090534
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18767096
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17924629
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17637533
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17530221
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17226110
88VDR_23849224_ChIP-Seq_CD4+_Human1.16435977
89* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16006916
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15998119
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14804777
92* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14134939
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.13605686
94* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13118436
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11421687
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11333795
97* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10428071
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09557037
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09504346
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09017186
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.08591447
102* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07596273
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.06578829
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04984599
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03939566
106* KDM5A_27292631_Chip-Seq_BREAST_Human1.02833245
107* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01628179
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01273238
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01140878
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.00873480
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99717220
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.99690973
113* GATA6_25053715_ChIP-Seq_YYC3_Human0.99646792
114* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98455819
115CHD1_26751641_Chip-Seq_LNCaP_Human0.98000078
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97524079
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97359223
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97069616
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96771925
120* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96508783
121* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96238047
122ETS1_20019798_ChIP-Seq_JURKAT_Human0.95815437
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95508683
124* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95165779
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94501428
126TFEB_21752829_ChIP-Seq_HELA_Human0.94113125
127DCP1A_22483619_ChIP-Seq_HELA_Human0.94013840
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93783998
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93056999
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91496602
131* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90964714
132* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90964714
133ERG_20517297_ChIP-Seq_VCAP_Human0.89828291
134* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89102174
135* RACK7_27058665_Chip-Seq_MCF-7_Human0.88991506
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.88957974
137* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87830209
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86453218
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86091479
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85703781
141XRN2_22483619_ChIP-Seq_HELA_Human0.84874035
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84414996
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.84243187
144* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83301449
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83163929
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82647821
147* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82439879
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80522903
149* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76749790
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75867112
151* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75855466
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.75186818
153AR_20517297_ChIP-Seq_VCAP_Human0.75175428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.63452443
2MP0002139_abnormal_hepatobiliary_system4.88097363
3MP0003806_abnormal_nucleotide_metabolis4.15583557
4MP0005365_abnormal_bile_salt3.68656621
5MP0003941_abnormal_skin_development3.41349071
6* MP0003186_abnormal_redox_activity3.38323588
7MP0004957_abnormal_blastocyst_morpholog3.26258996
8MP0005085_abnormal_gallbladder_physiolo3.01873884
9MP0005360_urolithiasis2.95296146
10MP0003693_abnormal_embryo_hatching2.71697304
11MP0004043_abnormal_pH_regulation2.70071297
12MP0008438_abnormal_cutaneous_collagen2.63216875
13MP0008932_abnormal_embryonic_tissue2.55552493
14MP0003111_abnormal_nucleus_morphology2.49008666
15MP0004272_abnormal_basement_membrane2.44731046
16MP0009697_abnormal_copulation2.41885418
17MP0005647_abnormal_sex_gland2.38660701
18MP0010329_abnormal_lipoprotein_level2.37519286
19MP0003705_abnormal_hypodermis_morpholog2.37141374
20MP0005332_abnormal_amino_acid2.36980706
21MP0010094_abnormal_chromosome_stability2.20148641
22MP0009840_abnormal_foam_cell2.19758123
23MP0003077_abnormal_cell_cycle2.16075573
24MP0001853_heart_inflammation2.07009437
25MP0002254_reproductive_system_inflammat1.98448450
26MP0001661_extended_life_span1.92851989
27MP0008058_abnormal_DNA_repair1.91540939
28MP0003656_abnormal_erythrocyte_physiolo1.88037514
29MP0008007_abnormal_cellular_replicative1.84975992
30MP0009764_decreased_sensitivity_to1.79891538
31MP0010234_abnormal_vibrissa_follicle1.76330000
32MP0001666_abnormal_nutrient_absorption1.75022604
33MP0009643_abnormal_urine_homeostasis1.74615832
34MP0005319_abnormal_enzyme/_coenzyme1.71612960
35MP0003690_abnormal_glial_cell1.71261573
36MP0001730_embryonic_growth_arrest1.67138949
37MP0004019_abnormal_vitamin_homeostasis1.65945124
38MP0000613_abnormal_salivary_gland1.64849723
39MP0006292_abnormal_olfactory_placode1.64768431
40MP0001764_abnormal_homeostasis1.64609802
41MP0005636_abnormal_mineral_homeostasis1.64067500
42MP0001293_anophthalmia1.57816082
43MP0003300_gastrointestinal_ulcer1.54462869
44MP0000751_myopathy1.51273453
45MP0002166_altered_tumor_susceptibility1.49589058
46MP0000749_muscle_degeneration1.48856169
47MP0000566_synostosis1.48185525
48MP0004782_abnormal_surfactant_physiolog1.46815728
49MP0000350_abnormal_cell_proliferation1.43032823
50MP0004233_abnormal_muscle_weight1.42355684
51MP0003191_abnormal_cellular_cholesterol1.40880529
52MP0001697_abnormal_embryo_size1.40556964
53MP0002697_abnormal_eye_size1.38360834
54MP0009672_abnormal_birth_weight1.37719527
55MP0003252_abnormal_bile_duct1.37427465
56MP0003011_delayed_dark_adaptation1.37172067
57MP0000609_abnormal_liver_physiology1.36996026
58MP0002938_white_spotting1.36975197
59MP0008789_abnormal_olfactory_epithelium1.36625610
60MP0001756_abnormal_urination1.34454861
61MP0005380_embryogenesis_phenotype1.33014373
62MP0001672_abnormal_embryogenesis/_devel1.33014373
63MP0001873_stomach_inflammation1.29451256
64MP0002080_prenatal_lethality1.27113987
65MP0005310_abnormal_salivary_gland1.26992857
66MP0002085_abnormal_embryonic_tissue1.26391906
67MP0002118_abnormal_lipid_homeostasis1.25072781
68MP0003984_embryonic_growth_retardation1.24222286
69MP0002084_abnormal_developmental_patter1.23940906
70MP0003315_abnormal_perineum_morphology1.23764593
71MP0010368_abnormal_lymphatic_system1.22632285
72MP0003942_abnormal_urinary_system1.21130323
73MP0009379_abnormal_foot_pigmentation1.20885828
74MP0003075_altered_response_to1.20637660
75MP0009053_abnormal_anal_canal1.20327868
76MP0003950_abnormal_plasma_membrane1.19396385
77MP0005584_abnormal_enzyme/coenzyme_acti1.19266979
78MP0005501_abnormal_skin_physiology1.18948530
79MP0005058_abnormal_lysosome_morphology1.18904982
80MP0004264_abnormal_extraembryonic_tissu1.18347662
81MP0009384_cardiac_valve_regurgitation1.17799155
82MP0002088_abnormal_embryonic_growth/wei1.17607518
83MP0002006_tumorigenesis1.16234179
84MP0000358_abnormal_cell_content/1.15587702
85MP0005083_abnormal_biliary_tract1.14875889
86MP0005166_decreased_susceptibility_to1.14869194
87MP0003937_abnormal_limbs/digits/tail_de1.13721193
88MP0006035_abnormal_mitochondrial_morpho1.13568195
89MP0010030_abnormal_orbit_morphology1.12236662
90MP0003567_abnormal_fetal_cardiomyocyte1.12093313
91MP0005408_hypopigmentation1.11213359
92MP0005330_cardiomyopathy1.08011788
93MP0010155_abnormal_intestine_physiology1.06549616
94MP0009765_abnormal_xenobiotic_induced1.05083883
95MP0003878_abnormal_ear_physiology1.04958029
96MP0005377_hearing/vestibular/ear_phenot1.04958029
97MP0004087_abnormal_muscle_fiber1.04135609
98MP0000490_abnormal_crypts_of1.02653112
99MP0004147_increased_porphyrin_level1.02437304
100MP0004084_abnormal_cardiac_muscle1.01192556
101MP0005275_abnormal_skin_tensile0.99804651
102MP0004185_abnormal_adipocyte_glucose0.98761814
103MP0005503_abnormal_tendon_morphology0.98616389
104MP0003638_abnormal_response/metabolism_0.98198386
105MP0002111_abnormal_tail_morphology0.97683532
106MP0005376_homeostasis/metabolism_phenot0.97123748
107MP0003786_premature_aging0.97114839
108MP0005499_abnormal_olfactory_system0.96854712
109MP0005394_taste/olfaction_phenotype0.96854712
110MP0005165_increased_susceptibility_to0.96552451
111MP0001765_abnormal_ion_homeostasis0.95979672
112MP0001849_ear_inflammation0.95817157
113MP0000343_altered_response_to0.95658910
114MP0001299_abnormal_eye_distance/0.94825561
115MP0002086_abnormal_extraembryonic_tissu0.93900252
116MP0005670_abnormal_white_adipose0.93802674
117MP0003724_increased_susceptibility_to0.93798184
118MP0010630_abnormal_cardiac_muscle0.93690625
119MP0005164_abnormal_response_to0.93491537
120MP0002269_muscular_atrophy0.92509732
121MP0002098_abnormal_vibrissa_morphology0.91899018
122MP0003279_aneurysm0.91481178
123MP0000313_abnormal_cell_death0.90482962
124* MP0002136_abnormal_kidney_physiology0.90440017
125MP0001286_abnormal_eye_development0.90397621
126MP0000759_abnormal_skeletal_muscle0.89772130
127MP0000750_abnormal_muscle_regeneration0.89203518
128MP0005023_abnormal_wound_healing0.88590493
129MP0002233_abnormal_nose_morphology0.87935089
130* MP0002132_abnormal_respiratory_system0.87834220
131MP0004036_abnormal_muscle_relaxation0.87797007
132MP0005623_abnormal_meninges_morphology0.87171604
133MP0003385_abnormal_body_wall0.87164510
134MP0006054_spinal_hemorrhage0.86939255
135MP0002234_abnormal_pharynx_morphology0.86857277
136MP0002092_abnormal_eye_morphology0.86380763
137MP0008872_abnormal_physiological_respon0.86156479
138MP0008469_abnormal_protein_level0.85344449
139MP0000428_abnormal_craniofacial_morphol0.84342515
140MP0006138_congestive_heart_failure0.84297362
141MP0000747_muscle_weakness0.84186326
142MP0002877_abnormal_melanocyte_morpholog0.83935738
143MP0001663_abnormal_digestive_system0.83536941
144MP0003566_abnormal_cell_adhesion0.83461499
145MP0002060_abnormal_skin_morphology0.80228129
146MP0005266_abnormal_metabolism0.80063541
147MP0009763_increased_sensitivity_to0.79426937
148MP0000598_abnormal_liver_morphology0.78210737
149MP0003329_amyloid_beta_deposits0.76937056
150MP0000604_amyloidosis0.76005393
151MP0002138_abnormal_hepatobiliary_system0.75604623
152MP0005464_abnormal_platelet_physiology0.75262536
153MP0003136_yellow_coat_color0.74744062
154MP0004197_abnormal_fetal_growth/weight/0.74435876
155MP0002108_abnormal_muscle_morphology0.73903568
156MP0005666_abnormal_adipose_tissue0.73742678
157MP0000465_gastrointestinal_hemorrhage0.72056867
158MP0010352_gastrointestinal_tract_polyps0.71942823
159MP0005381_digestive/alimentary_phenotyp0.71387837
160MP0000579_abnormal_nail_morphology0.71314769
161MP0003123_paternal_imprinting0.70567242
162MP0006036_abnormal_mitochondrial_physio0.70285951
163MP0008775_abnormal_heart_ventricle0.69937381
164MP0000467_abnormal_esophagus_morphology0.69772374
165MP0002972_abnormal_cardiac_muscle0.69705808
166MP0005508_abnormal_skeleton_morphology0.69474298
167MP0000477_abnormal_intestine_morphology0.69207277
168MP0009250_abnormal_appendicular_skeleto0.69121992
169MP0009703_decreased_birth_body0.68948708
170MP0003866_abnormal_defecation0.68440204
171MP0005220_abnormal_exocrine_pancreas0.66874487
172MP0002277_abnormal_respiratory_mucosa0.64991000
173MP0003718_maternal_effect0.64913158
174MP0000762_abnormal_tongue_morphology0.64758185
175MP0001845_abnormal_inflammatory_respons0.62201861
176MP0001881_abnormal_mammary_gland0.61559348
177MP0000537_abnormal_urethra_morphology0.61369182
178MP0005379_endocrine/exocrine_gland_phen0.60715877
179MP0002796_impaired_skin_barrier0.60042978
180MP0003868_abnormal_feces_composition0.59877223
181MP0009785_altered_susceptibility_to0.59781631
182MP0002876_abnormal_thyroid_physiology0.58417970

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.87212623
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19398285
3Abnormality of serine family amino acid metabolism (HP:0010894)4.19348569
4Abnormality of glycine metabolism (HP:0010895)4.19348569
5Reticulocytopenia (HP:0001896)3.89249416
6Abnormality of cochlea (HP:0000375)3.89006720
7Intrahepatic cholestasis (HP:0001406)3.81193014
8Abnormality of fatty-acid metabolism (HP:0004359)3.68108793
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42493357
10Macrocytic anemia (HP:0001972)3.42466156
11Hyperglycinemia (HP:0002154)3.38032135
12Aplasia involving bones of the upper limbs (HP:0009823)3.34020014
13Aplasia of the phalanges of the hand (HP:0009802)3.34020014
14Aplasia involving bones of the extremities (HP:0009825)3.34020014
15Acute encephalopathy (HP:0006846)3.31967960
16Acute necrotizing encephalopathy (HP:0006965)3.26087093
17Abnormality of glycolysis (HP:0004366)3.23975749
18Steatorrhea (HP:0002570)3.23721277
19Abnormal mitochondria in muscle tissue (HP:0008316)3.22452629
20Hyperammonemia (HP:0001987)3.21676090
21Fat malabsorption (HP:0002630)3.18781617
22Increased serum pyruvate (HP:0003542)3.14703935
23Xanthomatosis (HP:0000991)3.14119180
24Abnormality of cells of the erythroid lineage (HP:0012130)3.13984332
25Premature rupture of membranes (HP:0001788)3.13521908
26Hyperactive renin-angiotensin system (HP:0000841)3.10586371
27Prolonged partial thromboplastin time (HP:0003645)3.09226621
28Hypoglycemic coma (HP:0001325)3.04192763
29Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.89614098
30Hypobetalipoproteinemia (HP:0003563)2.89110967
31Generalized aminoaciduria (HP:0002909)2.88678347
32Abnormality of the axillary hair (HP:0100134)2.85983733
33Abnormality of secondary sexual hair (HP:0009888)2.85983733
34Onycholysis (HP:0001806)2.82853542
35Abnormality of the intrinsic pathway (HP:0010989)2.81966477
36Ketosis (HP:0001946)2.80095801
37Abnormal number of erythroid precursors (HP:0012131)2.77264944
38Facial shape deformation (HP:0011334)2.75948935
39Potter facies (HP:0002009)2.75948935
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74881599
41Morphological abnormality of the inner ear (HP:0011390)2.72103216
42Hyperlipoproteinemia (HP:0010980)2.71868074
43Nemaline bodies (HP:0003798)2.71738818
44Cerebral edema (HP:0002181)2.71244393
45Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.70047155
46Calcaneovalgus deformity (HP:0001848)2.69645368
47Protrusio acetabuli (HP:0003179)2.65898637
48Deep venous thrombosis (HP:0002625)2.60993870
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60472792
50Dicarboxylic aciduria (HP:0003215)2.60472792
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.59961872
52Hypoplasia of the uterus (HP:0000013)2.58697816
53Abnormal gallbladder physiology (HP:0012438)2.54784006
54Cholecystitis (HP:0001082)2.54784006
55Trismus (HP:0000211)2.50870095
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.49477182
57Ketoacidosis (HP:0001993)2.46804421
58Hypolipoproteinemia (HP:0010981)2.46052407
59Esophageal varix (HP:0002040)2.41739613
60Progressive macrocephaly (HP:0004481)2.39677639
61Deformed tarsal bones (HP:0008119)2.38333733
62Lethargy (HP:0001254)2.38072373
63Abnormality of methionine metabolism (HP:0010901)2.37655282
64Muscle fiber inclusion bodies (HP:0100299)2.35554266
65Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.34411818
66Polycythemia (HP:0001901)2.33851789
67Mitochondrial inheritance (HP:0001427)2.32796193
68Reduced antithrombin III activity (HP:0001976)2.31622608
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31546686
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31546686
71Back pain (HP:0003418)2.30519421
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30264975
73Hypoalphalipoproteinemia (HP:0003233)2.30129163
74Breech presentation (HP:0001623)2.29937551
75Aplasia/hypoplasia of the uterus (HP:0008684)2.29265779
76Abnormal hemoglobin (HP:0011902)2.28544245
77Pallor (HP:0000980)2.28404461
78Aplastic anemia (HP:0001915)2.28223892
79Abnormality of the umbilical cord (HP:0010881)2.28122312
80Delayed CNS myelination (HP:0002188)2.26738219
81Proximal tubulopathy (HP:0000114)2.26124696
82Metabolic acidosis (HP:0001942)2.24881462
83Progressive muscle weakness (HP:0003323)2.24123628
84Vacuolated lymphocytes (HP:0001922)2.23934902
85Exercise intolerance (HP:0003546)2.23205853
86Pterygium (HP:0001059)2.22978725
87Short hallux (HP:0010109)2.22195085
88Increased CSF lactate (HP:0002490)2.21291964
89Abnormality of serum amino acid levels (HP:0003112)2.20792826
90Microvesicular hepatic steatosis (HP:0001414)2.19718573
91Respiratory distress (HP:0002098)2.19489986
92Abnormality of the middle phalanges of the toes (HP:0010183)2.18235232
93Renal Fanconi syndrome (HP:0001994)2.17883198
94Abnormality of reticulocytes (HP:0004312)2.16708174
95Abnormalities of placenta or umbilical cord (HP:0001194)2.15732281
96Hyperbilirubinemia (HP:0002904)2.15528545
97Pancreatitis (HP:0001733)2.13062325
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12984636
99Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12680194
100Right ventricular cardiomyopathy (HP:0011663)2.12594635
101Abnormality of the calcaneus (HP:0008364)2.12299087
102Aplasia/Hypoplasia of the hallux (HP:0008362)2.12086260
103Abnormality of proline metabolism (HP:0010907)2.11671794
104Hydroxyprolinuria (HP:0003080)2.11671794
105Hepatocellular necrosis (HP:0001404)2.11344459
106Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10709172
107Increased hepatocellular lipid droplets (HP:0006565)2.10452880
108Type 1 muscle fiber predominance (HP:0003803)2.08216713
109Amniotic constriction ring (HP:0009775)2.07850826
110Abnormality of placental membranes (HP:0011409)2.07850826
111Hypoplastic left heart (HP:0004383)2.07442746
112Hepatic necrosis (HP:0002605)2.06912379
113Increased mean platelet volume (HP:0011877)2.02690186
114Bifid scrotum (HP:0000048)2.02324303
115Type I transferrin isoform profile (HP:0003642)2.01883620
116Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00959042
117Hypoplastic heart (HP:0001961)2.00954338
118Renal cortical cysts (HP:0000803)2.00495016
119Abnormal cartilage morphology (HP:0002763)2.00394731
120Abnormality of the common coagulation pathway (HP:0010990)1.97790310
121Increased intramyocellular lipid droplets (HP:0012240)1.97773140
122Exercise-induced muscle cramps (HP:0003710)1.96447908
123Glycosuria (HP:0003076)1.95427828
124Abnormality of urine glucose concentration (HP:0011016)1.95427828
125Abnormal delivery (HP:0001787)1.95031749
126Abnormality of the anterior horn cell (HP:0006802)1.94753710
127Degeneration of anterior horn cells (HP:0002398)1.94753710
128Short middle phalanx of the 5th finger (HP:0004220)1.92544411
129Abnormality of pyrimidine metabolism (HP:0004353)1.91700779
130Sensorimotor neuropathy (HP:0007141)1.90652610
131Hypoplasia of the thymus (HP:0000778)1.90429648
132Amyloidosis (HP:0011034)1.89088968
133Vertebral compression fractures (HP:0002953)1.88300277
134Abnormality of transition element cation homeostasis (HP:0011030)1.87980580
135Abnormality of the 2nd finger (HP:0004100)1.87288988
136Synostosis involving the elbow (HP:0003938)1.86194520
137Humeroradial synostosis (HP:0003041)1.86194520
138Fibular aplasia (HP:0002990)1.85625271
139Lipid accumulation in hepatocytes (HP:0006561)1.85270556
140Lactic acidosis (HP:0003128)1.85193886
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.84403025
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83638967
143Malnutrition (HP:0004395)1.83272327
144Chromsome breakage (HP:0040012)1.82240083
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81357264
146Microretrognathia (HP:0000308)1.81309973
147Multiple enchondromatosis (HP:0005701)1.80308581
148Symphalangism affecting the phalanges of the hand (HP:0009773)1.79126618
149Distal lower limb muscle weakness (HP:0009053)1.78701849
150Increased muscle lipid content (HP:0009058)1.78078609
151Abnormal tarsal ossification (HP:0008369)1.77963075
152Nausea (HP:0002018)1.77457055
153Spastic diplegia (HP:0001264)1.76489313
154Brushfield spots (HP:0001088)1.76342497
155Adactyly (HP:0009776)1.75968415
156Abnormality of dentin (HP:0010299)1.74613963
157Myoglobinuria (HP:0002913)1.74287643
158Late onset (HP:0003584)1.73486499
159Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73118237
160Ankle contracture (HP:0006466)1.72914361
161Abnormality of the proximal phalanges of the hand (HP:0009834)1.72825294
162Spinal rigidity (HP:0003306)1.72798631
163Cholelithiasis (HP:0001081)1.72633792
164Respiratory failure (HP:0002878)1.71134501
165Rough bone trabeculation (HP:0100670)1.67849873
166Rhabdomyolysis (HP:0003201)1.67526175
167Popliteal pterygium (HP:0009756)1.67040857
168Increased serum lactate (HP:0002151)1.66155471
169Abnormality of skeletal muscle fiber size (HP:0012084)1.64061959
170Gout (HP:0001997)1.63879337
171Redundant skin (HP:0001582)1.63091175
172Partial duplication of thumb phalanx (HP:0009944)1.63029856
173Abnormal lung lobation (HP:0002101)1.62477627
174Testicular atrophy (HP:0000029)1.62329940
175Abnormality of the tricuspid valve (HP:0001702)1.61552648
176Palpitations (HP:0001962)1.60845845
177Abnormal pupillary function (HP:0007686)1.60772061
178Increased connective tissue (HP:0009025)1.59052278
179Selective tooth agenesis (HP:0001592)1.58374680
180Abnormal gallbladder morphology (HP:0012437)1.58038760
181Generalized amyotrophy (HP:0003700)1.57438423
182Abnormal platelet volume (HP:0011876)1.56723903
183Megaloblastic anemia (HP:0001889)1.56233554
184Vertebral hypoplasia (HP:0008417)1.56213027
185Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56213027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.05262756
2BCKDK4.92852432
3ERN13.75218384
4LMTK23.68290843
5VRK23.64448817
6NEK12.99321343
7CDC72.85640859
8TAOK32.85242401
9SIK12.75508308
10TTK2.71575982
11FRK2.50184605
12AKT32.42574965
13PBK2.39350039
14EPHA22.30738777
15SRPK12.26353098
16RPS6KB22.10330194
17TESK11.92537455
18MAP3K31.90415643
19LRRK21.88333854
20MST1R1.87250912
21PLK31.85443460
22MAP3K21.79030811
23MYLK1.76155484
24MAP2K21.73803294
25STK101.60302436
26IRAK31.51603194
27LATS21.46284551
28SMG11.45938457
29PLK41.45080634
30STK161.42634558
31MAP3K121.38582855
32PDK21.36001834
33TESK21.33084734
34MAP2K31.32486773
35MAPKAPK31.29096864
36TRIB31.24235090
37BRSK11.23587747
38NME21.22263540
39PIK3CA1.20351613
40TTN1.20349920
41MKNK11.19263185
42EPHB21.19128591
43PLK11.18644828
44PIK3CG1.13668554
45ZAK1.12868428
46MAPK151.12335573
47EIF2AK31.06552043
48CHEK21.05730278
49BMX1.04563166
50PHKG21.04275729
51PHKG11.04275729
52JAK31.03097012
53NLK0.98413764
54NME10.96981147
55PTK20.96764920
56MET0.96701922
57SCYL20.95193640
58CDK70.95191194
59ARAF0.91001241
60PDK40.89895891
61PDK30.89895891
62TAF10.88966268
63TIE10.88597847
64PAK20.88378375
65KDR0.85068188
66PAK10.83549292
67STK30.83399490
68EIF2AK10.83375119
69MAP3K110.81313221
70CDK80.80591816
71PDGFRA0.79105881
72DMPK0.77578257
73AURKA0.76887570
74NEK20.75645484
75DAPK30.74356269
76MAP3K80.73876212
77LIMK10.73411259
78FLT30.71114236
79NEK90.70187806
80STK38L0.70133988
81BTK0.69787645
82CLK10.69274523
83OBSCN0.67246279
84WEE10.66974510
85TGFBR10.66931342
86MUSK0.66228641
87PTK60.65416934
88DYRK30.65367277
89PINK10.65288109
90LATS10.64893285
91PIM20.64817155
92RPS6KA40.64712678
93CHEK10.63402869
94PRKCI0.62382640
95BRAF0.61984385
96MAP3K140.61052971
97ABL20.60748612
98TBK10.60269178
99ATR0.59170548
100PRKG20.58650891
101GRK10.58196074
102CSNK2A20.57833552
103AKT20.57771278
104VRK10.56952034
105TYK20.54836372
106IKBKE0.54767153
107PASK0.54593219
108FGFR40.53619361
109EPHB10.52055432
110EEF2K0.51777393
111CSNK2A10.51372494
112STK40.50679020
113MAP2K60.49310502
114NTRK10.48928359
115JAK20.48872697
116TEC0.48239130
117TRPM70.47810071
118TRIM280.47167518
119MAP2K10.46286197
120ALK0.46212823
121FGFR10.46169146
122NEK60.44657703
123EIF2AK20.44203091
124MKNK20.44007535
125AURKB0.42570664
126PLK20.40542375
127CCNB10.39625667
128BUB10.39285081
129MATK0.38323125
130STK240.37771043
131RAF10.37753745
132TAOK20.36598265
133PAK40.35403293
134DAPK10.33890713
135TSSK60.33721520
136CSNK1E0.33000083
137ERBB40.32377236
138ILK0.31553750
139CDK10.31490605
140BRSK20.31195104
141IRAK10.30924305
142IKBKB0.30808389
143FER0.30518482
144ERBB20.30143142
145ATM0.29875861
146SGK30.29803807
147BMPR1B0.28869532
148CDK60.28104079
149MAPKAPK50.26806490
150ZAP700.25480316
151CAMK2G0.24813056
152SGK20.24539396
153GRK60.24298167
154ROCK10.23729751

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.73414119
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.38083469
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29540989
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.28188508
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.22694967
6Chemical carcinogenesis_Homo sapiens_hsa052042.99799667
7Mismatch repair_Homo sapiens_hsa034302.90853434
8Sulfur relay system_Homo sapiens_hsa041222.72195191
9Fatty acid degradation_Homo sapiens_hsa000712.68052049
10Nitrogen metabolism_Homo sapiens_hsa009102.60763704
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23969166
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.14529156
13Glutathione metabolism_Homo sapiens_hsa004802.08242497
14Propanoate metabolism_Homo sapiens_hsa006401.99045058
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89536467
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87653693
17Nucleotide excision repair_Homo sapiens_hsa034201.85791198
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.79555875
19Peroxisome_Homo sapiens_hsa041461.73033332
20Caffeine metabolism_Homo sapiens_hsa002321.72122330
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71179221
22Fatty acid metabolism_Homo sapiens_hsa012121.69655801
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.67976855
24Base excision repair_Homo sapiens_hsa034101.67437066
25Retinol metabolism_Homo sapiens_hsa008301.65528482
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65235322
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.59108502
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59098629
29Spliceosome_Homo sapiens_hsa030401.59064615
30beta-Alanine metabolism_Homo sapiens_hsa004101.55945360
31Huntingtons disease_Homo sapiens_hsa050161.55234670
32Tryptophan metabolism_Homo sapiens_hsa003801.53236229
33Histidine metabolism_Homo sapiens_hsa003401.50667633
34RNA transport_Homo sapiens_hsa030131.48912255
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46964670
36Selenocompound metabolism_Homo sapiens_hsa004501.46750318
37Homologous recombination_Homo sapiens_hsa034401.46238167
38Starch and sucrose metabolism_Homo sapiens_hsa005001.43089456
39Protein export_Homo sapiens_hsa030601.42075135
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38390889
41Folate biosynthesis_Homo sapiens_hsa007901.37574443
42Pentose phosphate pathway_Homo sapiens_hsa000301.36321235
43Cell cycle_Homo sapiens_hsa041101.31552226
44PPAR signaling pathway_Homo sapiens_hsa033201.29921424
45Fatty acid biosynthesis_Homo sapiens_hsa000611.28945387
46Arginine biosynthesis_Homo sapiens_hsa002201.28839469
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27812353
48Butanoate metabolism_Homo sapiens_hsa006501.25189504
49Alzheimers disease_Homo sapiens_hsa050101.22585696
50Fructose and mannose metabolism_Homo sapiens_hsa000511.21173457
51Carbon metabolism_Homo sapiens_hsa012001.20827070
52Biosynthesis of amino acids_Homo sapiens_hsa012301.17291507
53Galactose metabolism_Homo sapiens_hsa000521.17275199
54Non-homologous end-joining_Homo sapiens_hsa034501.15465357
55One carbon pool by folate_Homo sapiens_hsa006701.15069082
56Complement and coagulation cascades_Homo sapiens_hsa046101.14585039
57Arginine and proline metabolism_Homo sapiens_hsa003301.05924651
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05541295
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04633088
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02283020
61Pyruvate metabolism_Homo sapiens_hsa006201.00965391
62Fatty acid elongation_Homo sapiens_hsa000620.96398071
63Tyrosine metabolism_Homo sapiens_hsa003500.94785577
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94067007
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90771241
66Ribosome_Homo sapiens_hsa030100.89538576
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87250530
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86042742
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85912805
70Phenylalanine metabolism_Homo sapiens_hsa003600.85399504
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84304358
72Cardiac muscle contraction_Homo sapiens_hsa042600.81083065
73Fanconi anemia pathway_Homo sapiens_hsa034600.78533473
74N-Glycan biosynthesis_Homo sapiens_hsa005100.76587246
75Bile secretion_Homo sapiens_hsa049760.72745575
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71826787
77Thyroid cancer_Homo sapiens_hsa052160.71764152
78ABC transporters_Homo sapiens_hsa020100.71601968
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68885887
80Basal transcription factors_Homo sapiens_hsa030220.66843398
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66449425
82* Metabolic pathways_Homo sapiens_hsa011000.66227610
83RNA degradation_Homo sapiens_hsa030180.66038052
84p53 signaling pathway_Homo sapiens_hsa041150.65015983
85Proteasome_Homo sapiens_hsa030500.65013152
86ECM-receptor interaction_Homo sapiens_hsa045120.63822660
87mRNA surveillance pathway_Homo sapiens_hsa030150.58170807
88Pyrimidine metabolism_Homo sapiens_hsa002400.55996620
89Vitamin B6 metabolism_Homo sapiens_hsa007500.54103612
90Glycerolipid metabolism_Homo sapiens_hsa005610.50516625
91Steroid biosynthesis_Homo sapiens_hsa001000.49409733
92Mineral absorption_Homo sapiens_hsa049780.48931899
93Oxidative phosphorylation_Homo sapiens_hsa001900.48301469
94Basal cell carcinoma_Homo sapiens_hsa052170.48160916
95Other glycan degradation_Homo sapiens_hsa005110.47990449
96Adherens junction_Homo sapiens_hsa045200.47785643
97Vitamin digestion and absorption_Homo sapiens_hsa049770.46646859
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44598089
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.43110359
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42363585
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40521980
102Fat digestion and absorption_Homo sapiens_hsa049750.39896918
103Arachidonic acid metabolism_Homo sapiens_hsa005900.36490844
104Renin-angiotensin system_Homo sapiens_hsa046140.36384361
105Hippo signaling pathway_Homo sapiens_hsa043900.35279359
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.35266405
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34966811
108Legionellosis_Homo sapiens_hsa051340.34750581
109Oocyte meiosis_Homo sapiens_hsa041140.30815988
110Tight junction_Homo sapiens_hsa045300.30332791
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.28679372
112DNA replication_Homo sapiens_hsa030300.27026693
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26638027
114TGF-beta signaling pathway_Homo sapiens_hsa043500.26598670
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26546601
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.24980885
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24695955
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21990992
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20974176
120Staphylococcus aureus infection_Homo sapiens_hsa051500.20722651
121Parkinsons disease_Homo sapiens_hsa050120.19358287
122Hepatitis C_Homo sapiens_hsa051600.17024142
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15148329
124Bladder cancer_Homo sapiens_hsa052190.13345516
125Prion diseases_Homo sapiens_hsa050200.11483764
126RNA polymerase_Homo sapiens_hsa030200.11480458
127Lysosome_Homo sapiens_hsa041420.10750089
128Circadian rhythm_Homo sapiens_hsa047100.09824140
129African trypanosomiasis_Homo sapiens_hsa051430.07837593
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.06439663
131Purine metabolism_Homo sapiens_hsa002300.05984016

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