PRDX3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.91908719
2ventricular system development (GO:0021591)7.69010898
3regulation of cilium movement (GO:0003352)6.65968112
4photoreceptor cell maintenance (GO:0045494)6.12811529
5microtubule bundle formation (GO:0001578)5.72100803
6left/right pattern formation (GO:0060972)5.62497096
7eye photoreceptor cell development (GO:0042462)5.14640866
8peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.95641415
9photoreceptor cell development (GO:0042461)4.93642717
10left/right axis specification (GO:0070986)4.67949093
11regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.43123509
12cilium organization (GO:0044782)4.19995919
13regulation of DNA endoreduplication (GO:0032875)4.04461395
14lateral ventricle development (GO:0021670)4.01475364
15regulation of microtubule-based movement (GO:0060632)3.97849643
16hepatocyte differentiation (GO:0070365)3.94894481
17microtubule-based movement (GO:0007018)3.83561552
18interkinetic nuclear migration (GO:0022027)3.77189881
19peristalsis (GO:0030432)3.72356907
20oxidative demethylation (GO:0070989)3.64464690
21metanephric mesenchyme development (GO:0072075)3.61786853
22iron ion import (GO:0097286)3.61671645
23brain morphogenesis (GO:0048854)3.56698400
24cilium morphogenesis (GO:0060271)3.55433677
25cellular component assembly involved in morphogenesis (GO:0010927)3.53656658
26pericardium development (GO:0060039)3.53173714
27intraciliary transport (GO:0042073)3.39427381
28axis elongation (GO:0003401)3.39127981
29cilium assembly (GO:0042384)3.34605978
30negative regulation of complement activation (GO:0045916)3.16216860
31multicellular organismal aging (GO:0010259)3.13252127
32microtubule depolymerization (GO:0007019)3.09886995
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.05178212
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.05178212
35regulation of translation, ncRNA-mediated (GO:0045974)3.05178212
36kidney mesenchyme development (GO:0072074)3.04096652
37kidney morphogenesis (GO:0060993)3.03425413
38urinary tract smooth muscle contraction (GO:0014848)3.02720752
39fat-soluble vitamin biosynthetic process (GO:0042362)3.01192891
40regulation of interleukin-5 production (GO:0032674)2.98054452
41regulation of pigment cell differentiation (GO:0050932)2.88877809
42nucleus localization (GO:0051647)2.88731773
43negative regulation of protein activation cascade (GO:2000258)2.88669449
44protein localization to cilium (GO:0061512)2.80721262
45protein localization to microtubule cytoskeleton (GO:0072698)2.78400593
46determination of left/right symmetry (GO:0007368)2.73461284
47determination of bilateral symmetry (GO:0009855)2.72687051
48drug catabolic process (GO:0042737)2.71401829
49cell projection assembly (GO:0030031)2.70606752
50snRNA transcription (GO:0009301)2.70318447
51specification of symmetry (GO:0009799)2.67745214
52positive regulation of urine volume (GO:0035810)2.61979991
53regulation of transforming growth factor beta1 production (GO:0032908)2.61845297
54tryptophan catabolic process (GO:0006569)2.59925688
55indole-containing compound catabolic process (GO:0042436)2.59925688
56indolalkylamine catabolic process (GO:0046218)2.59925688
57maintenance of gastrointestinal epithelium (GO:0030277)2.57638737
58O-glycan processing (GO:0016266)2.55743822
59lung lobe morphogenesis (GO:0060463)2.55610469
60smooth muscle tissue development (GO:0048745)2.54537450
61lateral sprouting from an epithelium (GO:0060601)2.52444457
62protein localization to cytoskeleton (GO:0044380)2.48204004
63exogenous drug catabolic process (GO:0042738)2.46216900
64ubiquinone biosynthetic process (GO:0006744)2.45402107
65establishment of protein localization to Golgi (GO:0072600)2.45383364
66lung vasculature development (GO:0060426)2.44453507
67multicellular organismal reproductive behavior (GO:0033057)2.44230171
68synaptic vesicle docking involved in exocytosis (GO:0016081)2.42589755
69trophoblast giant cell differentiation (GO:0060707)2.39859011
70positive regulation of developmental pigmentation (GO:0048087)2.39526367
71kynurenine metabolic process (GO:0070189)2.39101006
72early endosome to late endosome transport (GO:0045022)2.39017158
73regulation of establishment of planar polarity (GO:0090175)2.37019744
74negative regulation of humoral immune response (GO:0002921)2.36730624
75microtubule severing (GO:0051013)2.35913345
76blastocyst development (GO:0001824)2.34823480
77regulation of p38MAPK cascade (GO:1900744)2.33763149
78tryptophan metabolic process (GO:0006568)2.32094556
79regulation of phospholipase A2 activity (GO:0032429)2.30668011
80microtubule-based process (GO:0007017)2.29287199
81phasic smooth muscle contraction (GO:0014821)2.27880444
82regulation of smooth muscle cell differentiation (GO:0051150)2.24459730
83protein O-linked glycosylation (GO:0006493)2.20946601
84lung development (GO:0030324)2.20420111
85Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.20140428
86parturition (GO:0007567)2.19505263
87genitalia morphogenesis (GO:0035112)2.18369601
88microtubule polymerization or depolymerization (GO:0031109)2.17350378
89regulation of integrin-mediated signaling pathway (GO:2001044)2.15961477
90embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13362674
91ovulation from ovarian follicle (GO:0001542)2.13337509
92embryonic cranial skeleton morphogenesis (GO:0048701)2.12061142
93cilium or flagellum-dependent cell motility (GO:0001539)18.2406219
94retinal rod cell development (GO:0046548)15.6924966
95retinal cone cell development (GO:0046549)15.1761198
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.5455507
97cilium movement (GO:0003341)12.7635192
98axoneme assembly (GO:0035082)12.6005909
99motile cilium assembly (GO:0044458)11.8558909
100axonemal dynein complex assembly (GO:0070286)11.3325423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.42569083
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.50772309
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.87924404
4AR_21572438_ChIP-Seq_LNCaP_Human3.79094235
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92587783
6IGF1R_20145208_ChIP-Seq_DFB_Human2.86445682
7GBX2_23144817_ChIP-Seq_PC3_Human2.77145342
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74026964
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.51737575
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.46964800
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.18341910
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13459849
13SMAD4_21799915_ChIP-Seq_A2780_Human2.09329592
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04717999
15FOXM1_26456572_ChIP-Seq_MCF-7_Human1.93896513
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93039703
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91704041
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.86823984
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85932911
20GATA1_22025678_ChIP-Seq_K562_Human1.85920487
21TP53_16413492_ChIP-PET_HCT116_Human1.83635204
22STAT3_23295773_ChIP-Seq_U87_Human1.76692115
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76463769
24AHR_22903824_ChIP-Seq_MCF-7_Human1.75165867
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.71327148
26TAF15_26573619_Chip-Seq_HEK293_Human1.68069321
27CBP_20019798_ChIP-Seq_JUKART_Human1.67912514
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67912514
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.67695585
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65890686
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.65462574
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.62012798
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59577039
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58196615
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57522729
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.53472567
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52559412
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.52246295
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51754147
40P300_19829295_ChIP-Seq_ESCs_Human1.47372102
41CJUN_26792858_Chip-Seq_BT549_Human1.46836807
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45253304
43CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43883232
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42964156
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42795854
46TP53_18474530_ChIP-ChIP_U2OS_Human1.39836025
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38738963
48FUS_26573619_Chip-Seq_HEK293_Human1.38738406
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36234861
50TCF4_23295773_ChIP-Seq_U87_Human1.34249173
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32866245
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.31334235
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.31193437
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30417368
55EWS_26573619_Chip-Seq_HEK293_Human1.29753965
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29744708
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29744708
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29143913
59BCAT_22108803_ChIP-Seq_LS180_Human1.27477121
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26676529
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25435105
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24689533
63P53_22387025_ChIP-Seq_ESCs_Mouse1.22522517
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22414186
65SMAD3_21741376_ChIP-Seq_HESCs_Human1.20671539
66KDM2B_26808549_Chip-Seq_REH_Human1.19918398
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19825228
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.19439817
69ER_23166858_ChIP-Seq_MCF-7_Human1.19050146
70VDR_22108803_ChIP-Seq_LS180_Human1.18162195
71AR_25329375_ChIP-Seq_VCAP_Human1.17708974
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13833043
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13567647
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12332731
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12248474
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.11573659
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.11053605
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09950967
79CDX2_22108803_ChIP-Seq_LS180_Human1.09449470
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.08123709
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.07560818
82RUNX2_22187159_ChIP-Seq_PCA_Human1.06023927
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03314707
84TP63_23658742_ChIP-Seq_EP156T_Human1.02193505
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.00857499
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99790230
87TCF4_22108803_ChIP-Seq_LS180_Human0.99628270
88SOX2_21211035_ChIP-Seq_LN229_Gbm0.99391329
89DROSHA_22980978_ChIP-Seq_HELA_Human0.99257334
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.98839811
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98807436
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94922864
93TBL1_22424771_ChIP-Seq_293T_Human0.93953448
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.92299954
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.91373992
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.91319228
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91311121
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89955783
99NANOG_19829295_ChIP-Seq_ESCs_Human0.89314325
100SOX2_19829295_ChIP-Seq_ESCs_Human0.89314325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.48090538
2MP0005623_abnormal_meninges_morphology4.09097388
3MP0005253_abnormal_eye_physiology3.51503672
4MP0001346_abnormal_lacrimal_gland3.46768512
5MP0003950_abnormal_plasma_membrane3.21411704
6MP0010368_abnormal_lymphatic_system3.01526717
7MP0005551_abnormal_eye_electrophysiolog2.96917074
8MP0008057_abnormal_DNA_replication2.69567281
9MP0000383_abnormal_hair_follicle2.51698024
10MP0004272_abnormal_basement_membrane2.47260458
11MP0001661_extended_life_span2.46264254
12MP0001958_emphysema2.29603873
13MP0010386_abnormal_urinary_bladder2.29592901
14MP0005083_abnormal_biliary_tract2.27244372
15MP0008438_abnormal_cutaneous_collagen2.22238021
16MP0005248_abnormal_Harderian_gland2.19301309
17MP0005503_abnormal_tendon_morphology2.18914458
18MP0004043_abnormal_pH_regulation2.15856356
19MP0005275_abnormal_skin_tensile2.14981198
20MP0005360_urolithiasis2.09498847
21MP0003045_fibrosis2.01867864
22MP0005085_abnormal_gallbladder_physiolo2.01863244
23MP0006054_spinal_hemorrhage1.94243219
24MP0010030_abnormal_orbit_morphology1.92528948
25MP0002168_other_aberrant_phenotype1.88131163
26MP0004145_abnormal_muscle_electrophysio1.87358253
27MP0003195_calcinosis1.82143014
28MP0005195_abnormal_posterior_eye1.78487106
29MP0000569_abnormal_digit_pigmentation1.73430218
30MP0010678_abnormal_skin_adnexa1.72263829
31MP0003868_abnormal_feces_composition1.68601681
32MP0010352_gastrointestinal_tract_polyps1.66802179
33MP0005377_hearing/vestibular/ear_phenot1.63849813
34MP0003878_abnormal_ear_physiology1.63849813
35MP0008875_abnormal_xenobiotic_pharmacok1.62280237
36MP0009780_abnormal_chondrocyte_physiolo1.61837547
37MP0001851_eye_inflammation1.59552777
38MP0002282_abnormal_trachea_morphology1.55689486
39MP0002160_abnormal_reproductive_system1.53074906
40MP0005391_vision/eye_phenotype1.51035234
41MP0003941_abnormal_skin_development1.46578996
42MP0002139_abnormal_hepatobiliary_system1.46531440
43MP0001879_abnormal_lymphatic_vessel1.46313530
44MP0000767_abnormal_smooth_muscle1.45872436
45MP0002108_abnormal_muscle_morphology1.43564294
46MP0002822_catalepsy1.42060287
47MP0005395_other_phenotype1.38177886
48MP0004036_abnormal_muscle_relaxation1.37285211
49MP0009046_muscle_twitch1.33263727
50MP0006138_congestive_heart_failure1.27533757
51MP0001299_abnormal_eye_distance/1.17363216
52MP0002060_abnormal_skin_morphology1.13224884
53MP0001666_abnormal_nutrient_absorption1.06756233
54MP0004147_increased_porphyrin_level0.98371443
55MP0009384_cardiac_valve_regurgitation0.97877814
56MP0009115_abnormal_fat_cell0.94518900
57MP0008961_abnormal_basal_metabolism0.94043346
58MP0003935_abnormal_craniofacial_develop0.93901592
59MP0002135_abnormal_kidney_morphology0.92933299
60MP0010329_abnormal_lipoprotein_level0.92790354
61MP0000631_abnormal_neuroendocrine_gland0.91841403
62MP0002229_neurodegeneration0.91316716
63MP0003646_muscle_fatigue0.90054869
64MP0005388_respiratory_system_phenotype0.89862293
65MP0002133_abnormal_respiratory_system0.89862293
66MP0000534_abnormal_ureter_morphology0.89344162
67MP0005595_abnormal_vascular_smooth0.89225243
68MP0005164_abnormal_response_to0.88954653
69MP0000751_myopathy0.88702227
70MP0005646_abnormal_pituitary_gland0.86763633
71MP0002876_abnormal_thyroid_physiology0.85840484
72MP0009697_abnormal_copulation0.83333996
73MP0000462_abnormal_digestive_system0.83295735
74MP0005220_abnormal_exocrine_pancreas0.82233482
75MP0000427_abnormal_hair_cycle0.82228018
76MP0001177_atelectasis0.81637858
77MP0009643_abnormal_urine_homeostasis0.80610260
78MP0002254_reproductive_system_inflammat0.78288404
79MP0002277_abnormal_respiratory_mucosa0.77534230
80MP0001324_abnormal_eye_pigmentation0.75548116
81MP0001963_abnormal_hearing_physiology0.75203936
82MP0000639_abnormal_adrenal_gland0.74998202
83MP0002128_abnormal_blood_circulation0.73348952
84MP0005332_abnormal_amino_acid0.72806714
85MP0003942_abnormal_urinary_system0.72037403
86MP0005620_abnormal_muscle_contractility0.70888483
87MP0005187_abnormal_penis_morphology0.70143431
88MP0000465_gastrointestinal_hemorrhage0.70129443
89MP0001502_abnormal_circadian_rhythm0.69027215
90MP0005023_abnormal_wound_healing0.64908656
91MP0005389_reproductive_system_phenotype0.64264342
92MP0003656_abnormal_erythrocyte_physiolo0.62150661
93MP0002925_abnormal_cardiovascular_devel0.61766196
94MP0000627_abnormal_mammary_gland0.61229607
95MP0003943_abnormal_hepatobiliary_system0.60515071
96MP0004084_abnormal_cardiac_muscle0.59908590
97MP0001873_stomach_inflammation0.59613820
98MP0003718_maternal_effect0.59562742
99MP0005645_abnormal_hypothalamus_physiol0.58701092
100MP0004133_heterotaxia0.57348741

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)8.76086179
2Abnormal ciliary motility (HP:0012262)8.56472975
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.15576980
4Abnormal respiratory epithelium morphology (HP:0012253)7.73098997
5Abnormal respiratory motile cilium morphology (HP:0005938)7.73098997
6Abnormal respiratory motile cilium physiology (HP:0012261)7.39878989
7Chronic hepatic failure (HP:0100626)6.20368686
8Tubulointerstitial nephritis (HP:0001970)5.94029369
9Abnormal rod and cone electroretinograms (HP:0008323)5.41119167
10Rhinitis (HP:0012384)5.34610489
11Chronic bronchitis (HP:0004469)5.32976246
12Bony spicule pigmentary retinopathy (HP:0007737)4.59937718
13Constricted visual fields (HP:0001133)4.43515959
14Bronchiectasis (HP:0002110)4.38373164
15Aortic aneurysm (HP:0004942)4.28561104
16Bronchitis (HP:0012387)4.01741060
17Nasal polyposis (HP:0100582)3.93615999
18Subcapsular cataract (HP:0000523)3.87263022
19Cone-rod dystrophy (HP:0000548)3.45041165
20Hypoalphalipoproteinemia (HP:0003233)3.36230247
21Abnormality of the nasal mucosa (HP:0000433)3.25717986
22Abnormal hair whorl (HP:0010721)3.20930494
23Menstrual irregularities (HP:0000858)3.13250542
24Recurrent bronchitis (HP:0002837)3.11516869
25Renovascular hypertension (HP:0100817)2.97719727
26Recurrent sinusitis (HP:0011108)2.86935589
27Progressive sensorineural hearing impairment (HP:0000408)2.85580636
28Tubulointerstitial abnormality (HP:0001969)2.74957435
29Insulin-resistant diabetes mellitus (HP:0000831)2.68412421
30Supernumerary spleens (HP:0009799)2.58078472
31Recurrent otitis media (HP:0000403)2.52464997
32Posterior subcapsular cataract (HP:0007787)2.39232537
33Chronic sinusitis (HP:0011109)2.37737702
34Hyperactive renin-angiotensin system (HP:0000841)2.29138344
35Abnormality of the fingertips (HP:0001211)2.19408577
36Decreased circulating renin level (HP:0003351)2.19163397
37Premature skin wrinkling (HP:0100678)2.16070804
38Polar cataract (HP:0010696)2.15752091
39Infertility (HP:0000789)2.11433137
40Portal hypertension (HP:0001409)2.06653012
41Macroorchidism (HP:0000053)2.04656026
42Long nose (HP:0003189)2.00757268
43Dynein arm defect of respiratory motile cilia (HP:0012255)12.4501292
44Absent/shortened dynein arms (HP:0200106)12.4501292
45Nephronophthisis (HP:0000090)1.97967705
46Increased purine levels (HP:0004368)1.96140914
47Hyperuricemia (HP:0002149)1.96140914
48Hypolipoproteinemia (HP:0010981)1.92532351
49Heterotopia (HP:0002282)1.92426761
50Abnormality of the renal medulla (HP:0100957)1.86067009
51Abnormality of the hepatic vasculature (HP:0006707)1.84024163
52Bell-shaped thorax (HP:0001591)1.83360646
53Anteriorly placed anus (HP:0001545)1.77319949
54Partial agenesis of the corpus callosum (HP:0001338)1.73593356
55Scanning speech (HP:0002168)1.73549713
56Narrow nasal bridge (HP:0000446)1.72801489
57Delayed closure of the anterior fontanelle (HP:0001476)1.72650233
58Deep philtrum (HP:0002002)1.71084086
59Occipital encephalocele (HP:0002085)1.68578581
60Hyperkalemia (HP:0002153)1.67946049
61Abnormality of midbrain morphology (HP:0002418)1.67051684
62Molar tooth sign on MRI (HP:0002419)1.67051684
63Growth hormone deficiency (HP:0000824)1.64951171
64Medial flaring of the eyebrow (HP:0010747)1.59415903
65Wide anterior fontanel (HP:0000260)1.58511822
66Hamartoma of the eye (HP:0010568)1.54198128
67Congenital primary aphakia (HP:0007707)1.53151340
68Large for gestational age (HP:0001520)1.52969465
69Central scotoma (HP:0000603)1.50369357
70Aortic dissection (HP:0002647)1.50130008
71Narrow palate (HP:0000189)1.49066888
72Papillary thyroid carcinoma (HP:0002895)1.48350255
73Type II diabetes mellitus (HP:0005978)1.46523094
74Gait imbalance (HP:0002141)1.46018390
75Recurrent pneumonia (HP:0006532)1.44473195
76Nephritis (HP:0000123)1.43796017
77Truncal obesity (HP:0001956)1.41682580
78Goiter (HP:0000853)1.40845030
79Cerebellar dysplasia (HP:0007033)1.40398929
80Abnormality of the astrocytes (HP:0100707)1.40382892
81Astrocytoma (HP:0009592)1.40382892
82Renal salt wasting (HP:0000127)1.39207327
83Neoplasm of the heart (HP:0100544)1.36286401
84Gingivitis (HP:0000230)1.36031351
85Nephrogenic diabetes insipidus (HP:0009806)1.35940739
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.35847924
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.34692052
88Scotoma (HP:0000575)1.34503569
89Broad hallux (HP:0010055)1.34444911
90Retinitis pigmentosa (HP:0000510)1.34297344
91Progressive hearing impairment (HP:0001730)1.33627677
92Abnormality of the nasal septum (HP:0000419)1.32874432
93Dilatation of the ascending aorta (HP:0005111)1.31346010
94Tubular atrophy (HP:0000092)1.31084087
95Nephrocalcinosis (HP:0000121)1.30615195
96Abnormality of the 2nd finger (HP:0004100)1.29843888
97Hypokalemic alkalosis (HP:0001949)1.29483990
98Dental crowding (HP:0000678)1.28407771
99Vaginal atresia (HP:0000148)1.27973021
100Intrahepatic cholestasis (HP:0001406)1.27601622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.02512392
2BCR3.69365809
3MAP4K23.63204851
4MST43.54449974
5MAPK152.91977297
6STK162.87237137
7CDK122.76210267
8PIK3CA2.70176775
9LATS12.34168920
10TYK22.02903270
11IRAK12.01918797
12ERBB21.94230059
13CDK81.91069412
14SGK21.85648089
15MST1R1.81755666
16AKT31.74574483
17MYLK1.66984900
18STK391.60199570
19MET1.37039799
20GRK11.36036450
21FER1.31429138
22DMPK1.30987582
23CSNK1A1L1.28002333
24TLK11.24016248
25SGK2231.22855604
26SGK4941.22855604
27BMPR1B1.22511364
28MUSK1.19156174
29EPHA31.16636184
30MAP3K71.15137594
31OXSR11.13945468
32EIF2AK31.13358293
33NLK1.09567013
34TRPM71.07188686
35TTN1.06029467
36CDC42BPA1.05757830
37TGFBR11.04718977
38RPS6KA21.01493243
39PDGFRB0.95374293
40NEK90.93720240
41FGFR20.92194748
42NUAK10.88072443
43STK110.87347334
44WNK10.86982983
45SGK30.85581995
46OBSCN0.82378169
47STK30.81468726
48MAP3K20.81161735
49ACVR1B0.80302145
50PAK30.77763345
51PNCK0.76060890
52STK38L0.75754530
53PRKCE0.74027795
54PIK3CG0.70644309
55MKNK20.70561959
56MARK20.69121394
57CSNK1G10.68962439
58CLK10.67891982
59MELK0.66836863
60EIF2AK10.65176763
61JAK10.63808294
62GSK3A0.63491877
63IRAK20.63207125
64CHUK0.61020301
65EGFR0.60512153
66BLK0.60204322
67PLK20.59791080
68MAPKAPK20.59603512
69PTK60.59593754
70ZAK0.58632185
71MAP3K40.57897264
72PDK20.57289503
73RPS6KA60.55934495
74PRKCI0.55908990
75CAMK1G0.53257446
76ADRBK10.52968866
77PBK0.52731714
78TIE10.50617837
79FGFR10.50225202
80ERBB40.47960759
81INSRR0.47367771
82PTK2B0.45926618
83BUB10.43260619
84DAPK20.42802298
85ADRBK20.42140327
86BRD40.38305553
87MTOR0.37920217
88PRKD10.37536308
89AKT20.37475673
90WNK30.36640525
91RPS6KC10.36326969
92RPS6KL10.36326969
93STK40.35910567
94IRAK40.35440581
95ROCK10.35046409
96WNK40.34172559
97CAMK2A0.33685811
98VRK10.33296369
99TRIM280.32482256
100TGFBR20.31306885

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.11462213
2ABC transporters_Homo sapiens_hsa020103.17435965
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.09811041
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.91807274
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.57080981
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56980978
7Retinol metabolism_Homo sapiens_hsa008302.37588656
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36822886
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06245680
10Chemical carcinogenesis_Homo sapiens_hsa052042.05179614
11Histidine metabolism_Homo sapiens_hsa003401.99713669
12ECM-receptor interaction_Homo sapiens_hsa045121.98310435
13Circadian rhythm_Homo sapiens_hsa047101.95454609
14Adherens junction_Homo sapiens_hsa045201.93670131
15Complement and coagulation cascades_Homo sapiens_hsa046101.93305448
16Arginine biosynthesis_Homo sapiens_hsa002201.90424601
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85642582
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78652579
19Linoleic acid metabolism_Homo sapiens_hsa005911.72663720
20Tryptophan metabolism_Homo sapiens_hsa003801.66551528
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56801119
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55071953
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51219064
24Sphingolipid metabolism_Homo sapiens_hsa006001.49952122
25Huntingtons disease_Homo sapiens_hsa050161.48529512
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47581367
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40092284
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36856802
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.26046791
30Focal adhesion_Homo sapiens_hsa045101.20825690
31Small cell lung cancer_Homo sapiens_hsa052221.16650489
32Dilated cardiomyopathy_Homo sapiens_hsa054141.11320038
33Peroxisome_Homo sapiens_hsa041461.09495616
34Lysine degradation_Homo sapiens_hsa003101.06962962
35Protein digestion and absorption_Homo sapiens_hsa049741.06592868
36Fatty acid degradation_Homo sapiens_hsa000711.05210536
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02617702
38Mineral absorption_Homo sapiens_hsa049781.01404557
39beta-Alanine metabolism_Homo sapiens_hsa004100.98936361
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.98020323
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97604453
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.97509683
43Nitrogen metabolism_Homo sapiens_hsa009100.96147614
44Taste transduction_Homo sapiens_hsa047420.95030960
45Tight junction_Homo sapiens_hsa045300.94148233
46Dorso-ventral axis formation_Homo sapiens_hsa043200.94043332
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90862645
48Starch and sucrose metabolism_Homo sapiens_hsa005000.90559468
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86005560
50Amoebiasis_Homo sapiens_hsa051460.85469568
51TGF-beta signaling pathway_Homo sapiens_hsa043500.84897648
52Tyrosine metabolism_Homo sapiens_hsa003500.83089940
53One carbon pool by folate_Homo sapiens_hsa006700.81200287
54Propanoate metabolism_Homo sapiens_hsa006400.79612827
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79563467
56Hematopoietic cell lineage_Homo sapiens_hsa046400.78527006
57Phototransduction_Homo sapiens_hsa047440.76212727
58Arachidonic acid metabolism_Homo sapiens_hsa005900.70687543
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69489173
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67575644
61PPAR signaling pathway_Homo sapiens_hsa033200.64453653
62Nicotine addiction_Homo sapiens_hsa050330.63288185
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61073162
64Phenylalanine metabolism_Homo sapiens_hsa003600.59469578
65Vitamin B6 metabolism_Homo sapiens_hsa007500.53874573
66Proteoglycans in cancer_Homo sapiens_hsa052050.52342018
67Ovarian steroidogenesis_Homo sapiens_hsa049130.51137751
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49862052
69Regulation of autophagy_Homo sapiens_hsa041400.49302402
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48411801
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47085369
72Basal transcription factors_Homo sapiens_hsa030220.47003738
73Inositol phosphate metabolism_Homo sapiens_hsa005620.46779863
74Hippo signaling pathway_Homo sapiens_hsa043900.43557838
75Prostate cancer_Homo sapiens_hsa052150.43374580
76Salivary secretion_Homo sapiens_hsa049700.42367301
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.42288911
78Vitamin digestion and absorption_Homo sapiens_hsa049770.42271029
79Caffeine metabolism_Homo sapiens_hsa002320.42157454
80Arginine and proline metabolism_Homo sapiens_hsa003300.40612772
81Glutamatergic synapse_Homo sapiens_hsa047240.39132415
82Bile secretion_Homo sapiens_hsa049760.37551736
83ErbB signaling pathway_Homo sapiens_hsa040120.37525144
84Prolactin signaling pathway_Homo sapiens_hsa049170.36653682
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36490090
86Calcium signaling pathway_Homo sapiens_hsa040200.34844875
87Serotonergic synapse_Homo sapiens_hsa047260.34104962
88Fatty acid biosynthesis_Homo sapiens_hsa000610.31613114
89Thyroid cancer_Homo sapiens_hsa052160.30149814
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29694418
91MicroRNAs in cancer_Homo sapiens_hsa052060.27521510
92Systemic lupus erythematosus_Homo sapiens_hsa053220.27299246
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26760875
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26432558
95Basal cell carcinoma_Homo sapiens_hsa052170.25786134
96Hedgehog signaling pathway_Homo sapiens_hsa043400.25353939
97Biosynthesis of amino acids_Homo sapiens_hsa012300.25332282
98Melanoma_Homo sapiens_hsa052180.24844449
99GABAergic synapse_Homo sapiens_hsa047270.24262632
100Pathways in cancer_Homo sapiens_hsa052000.23136894

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