PRDM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR domain and multiple zinc-finger domains. The encoded protein is involved in regulation of vascular smooth muscle cells (VSMC) contractile proteins. Mutations in this gene result in patent ductus arteriosus 3 (PDA3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1respiratory tube development (GO:0030323)6.40600932
2paraxial mesoderm development (GO:0048339)5.42947563
3embryonic skeletal joint morphogenesis (GO:0060272)5.38612099
4metanephric mesenchyme development (GO:0072075)5.09170866
5notochord development (GO:0030903)5.00224961
6tachykinin receptor signaling pathway (GO:0007217)4.89247937
7prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.83501257
8kidney mesenchyme development (GO:0072074)4.78130238
9lung morphogenesis (GO:0060425)4.76204713
10regulation of organ formation (GO:0003156)4.59634566
11lung vasculature development (GO:0060426)4.54955040
12regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.37773185
13regulation of transforming growth factor beta2 production (GO:0032909)4.37536207
14peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.22381866
15regulation of cardioblast proliferation (GO:0003264)4.19897723
16regulation of secondary heart field cardioblast proliferation (GO:0003266)4.19897723
17regulation of mesoderm development (GO:2000380)4.18918044
18cell differentiation involved in metanephros development (GO:0072202)4.16491204
19cardiac myofibril assembly (GO:0055003)4.15952545
20lymph vessel development (GO:0001945)4.14847802
21endocardial cushion development (GO:0003197)4.08281053
22* regulation of smooth muscle cell differentiation (GO:0051150)4.05639406
23mesenchymal cell differentiation involved in kidney development (GO:0072161)4.04917359
24mesenchymal cell differentiation involved in renal system development (GO:2001012)4.04917359
25mitotic chromosome condensation (GO:0007076)4.01089819
26mitotic metaphase plate congression (GO:0007080)3.99909599
27ventricular cardiac muscle cell development (GO:0055015)3.91472702
28branching involved in prostate gland morphogenesis (GO:0060442)3.88114253
29regulation of cardioblast differentiation (GO:0051890)3.87828175
30outflow tract septum morphogenesis (GO:0003148)3.87592565
31polarized epithelial cell differentiation (GO:0030859)3.84968529
32peripheral nervous system neuron development (GO:0048935)3.84498769
33positive regulation of endothelial cell differentiation (GO:0045603)3.78485255
34regulation of female gonad development (GO:2000194)3.67275064
35proximal/distal pattern formation (GO:0009954)3.59046182
36embryonic forelimb morphogenesis (GO:0035115)3.57689942
37regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.55972950
38uterus development (GO:0060065)3.55412325
39developmental induction (GO:0031128)3.53729110
40cell migration involved in gastrulation (GO:0042074)3.53065684
41positive regulation of DNA-dependent DNA replication (GO:2000105)3.51804533
42cell-cell signaling involved in cell fate commitment (GO:0045168)3.50602259
43epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.50152015
44metanephros development (GO:0001656)3.49740319
45regulation of meiosis (GO:0040020)3.47635261
46regulation of sister chromatid cohesion (GO:0007063)3.46987382
47mesenchymal cell proliferation (GO:0010463)3.44809310
48positive regulation of digestive system process (GO:0060456)3.42625324
49cardiac muscle cell development (GO:0055013)3.40905118
50regulation of heart morphogenesis (GO:2000826)3.40570849
51embryonic foregut morphogenesis (GO:0048617)3.40191746
52metaphase plate congression (GO:0051310)3.39774234
53organ formation (GO:0048645)3.37799750
54* negative regulation of smooth muscle cell differentiation (GO:0051151)3.36170978
55cardiac cell development (GO:0055006)3.35074619
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.33035244
57cardiac epithelial to mesenchymal transition (GO:0060317)3.32902711
58positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.29402633
59embryonic skeletal system morphogenesis (GO:0048704)3.28690298
60forelimb morphogenesis (GO:0035136)3.28611063
61cartilage morphogenesis (GO:0060536)3.27627594
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22698099
63cell proliferation involved in kidney development (GO:0072111)3.19657170
64negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.19259550
65cardiac right ventricle morphogenesis (GO:0003215)3.16991429
66chromosome organization involved in meiosis (GO:0070192)3.13656612
67positive regulation of SMAD protein import into nucleus (GO:0060391)3.11989931
68diaphragm development (GO:0060539)3.10268267
69negative regulation of androgen receptor signaling pathway (GO:0060766)3.07037788
70type B pancreatic cell development (GO:0003323)3.06572539
71positive regulation of embryonic development (GO:0040019)3.06546564
72positive regulation of epithelial to mesenchymal transition (GO:0010718)3.05931538
73mesodermal cell differentiation (GO:0048333)3.05677155
74attachment of spindle microtubules to kinetochore (GO:0008608)3.05504796
75organ induction (GO:0001759)3.04823681
76piRNA metabolic process (GO:0034587)3.04366785
77outer ear morphogenesis (GO:0042473)3.04199388
78hippo signaling (GO:0035329)3.03440776
79myofibril assembly (GO:0030239)3.01130197
80meiotic chromosome segregation (GO:0045132)3.00615137
81lung secretory cell differentiation (GO:0061140)2.99697599
82establishment of chromosome localization (GO:0051303)2.98527128
83cranial nerve morphogenesis (GO:0021602)2.98461290
84mitotic sister chromatid segregation (GO:0000070)2.98333451
85pre-miRNA processing (GO:0031054)2.98324306
86skeletal system morphogenesis (GO:0048705)2.97824798
87mesenchymal-epithelial cell signaling (GO:0060638)2.95715600
88DNA synthesis involved in DNA repair (GO:0000731)2.95683801
89negative regulation of striated muscle cell apoptotic process (GO:0010664)2.95633912
90synaptonemal complex assembly (GO:0007130)2.94954591
91negative regulation of chondrocyte differentiation (GO:0032331)2.94545080
92mesenchyme development (GO:0060485)2.93886438
93reproductive system development (GO:0061458)2.93154507
94mesonephros development (GO:0001823)2.93151444
95mitotic sister chromatid cohesion (GO:0007064)2.92950238
96embryonic digestive tract morphogenesis (GO:0048557)2.92846702
97embryonic organ morphogenesis (GO:0048562)2.92167087
98regulation of mitotic spindle organization (GO:0060236)2.90290444
99cilium or flagellum-dependent cell motility (GO:0001539)2.90238537
100actin-mediated cell contraction (GO:0070252)2.89032483
101collagen fibril organization (GO:0030199)2.88605417
102mesonephric tubule development (GO:0072164)2.88571311
103cell migration involved in heart development (GO:0060973)2.88339880
104muscle filament sliding (GO:0030049)2.88321403
105actin-myosin filament sliding (GO:0033275)2.88321403
106relaxation of smooth muscle (GO:0044557)2.87137480
107regulation of SMAD protein import into nucleus (GO:0060390)2.86650613
108middle ear morphogenesis (GO:0042474)2.85757243
109kinetochore organization (GO:0051383)2.85715644
110regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.84177535
111glomerular basement membrane development (GO:0032836)2.83709734
112positive regulation of cardiac muscle tissue growth (GO:0055023)2.83416967
113glomerulus development (GO:0032835)2.83253566
114protein localization to kinetochore (GO:0034501)2.82054646
115nuclear pore complex assembly (GO:0051292)2.81285879
116cardiac muscle tissue morphogenesis (GO:0055008)2.80710140
117cranial suture morphogenesis (GO:0060363)2.79928925
118ureteric bud development (GO:0001657)2.79922977
119regulation of cardiac muscle cell proliferation (GO:0060043)2.79552210
120cell proliferation involved in metanephros development (GO:0072203)2.78315885
121embryonic digit morphogenesis (GO:0042733)2.77591124
122pericardium development (GO:0060039)2.77585178
123mesonephric epithelium development (GO:0072163)2.76690872
124mesenchymal cell differentiation (GO:0048762)2.76223793
125regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.73628645
126embryonic heart tube development (GO:0035050)2.72550570
127lung alveolus development (GO:0048286)2.72543657
128lung lobe morphogenesis (GO:0060463)2.72509139
129synapsis (GO:0007129)2.71823615
130embryonic skeletal system development (GO:0048706)2.71430406
131nodal signaling pathway (GO:0038092)2.71037009
132embryonic hindlimb morphogenesis (GO:0035116)2.71008131
133regulation of cardiac muscle tissue development (GO:0055024)2.69893431
134cardiac chamber formation (GO:0003207)2.69258145
135thyroid gland development (GO:0030878)2.68886316
136regulation of cardiac muscle tissue growth (GO:0055021)2.68624916
137regulation of spindle organization (GO:0090224)2.67538417
138regulation of endothelial cell differentiation (GO:0045601)2.65660328
139wound healing, spreading of cells (GO:0044319)2.65527409
140skeletal muscle organ development (GO:0060538)2.64872689
141positive regulation of cardiac muscle tissue development (GO:0055025)2.64542320
142sister chromatid segregation (GO:0000819)2.64324575
143axis elongation (GO:0003401)2.64255857
144regulation of meiotic cell cycle (GO:0051445)2.63861842
145positive regulation of cardiac muscle cell proliferation (GO:0060045)2.63283309
146cardiac septum morphogenesis (GO:0060411)2.63139946
147spindle checkpoint (GO:0031577)2.61664144
148extracellular matrix assembly (GO:0085029)2.60941384
149synaptonemal complex organization (GO:0070193)2.60203756
150smooth muscle tissue development (GO:0048745)2.58350885
151secondary heart field specification (GO:0003139)2.58005439
152heart field specification (GO:0003128)2.58005439
153bone trabecula formation (GO:0060346)2.57668429
154signal transduction involved in regulation of gene expression (GO:0023019)2.57368703
155sarcomere organization (GO:0045214)2.57223516
156cardiac ventricle formation (GO:0003211)2.56862936
157fibroblast migration (GO:0010761)2.56466558
158base-excision repair, AP site formation (GO:0006285)2.56371633
159muscle tissue morphogenesis (GO:0060415)2.56035238
160mesenchyme morphogenesis (GO:0072132)2.56007379
161morphogenesis of an endothelium (GO:0003159)2.55571270
162endothelial tube morphogenesis (GO:0061154)2.55571270
163establishment of apical/basal cell polarity (GO:0035089)2.55021783
164male genitalia development (GO:0030539)2.53876465
165regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53336646
166positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.53081434
167negative regulation of cartilage development (GO:0061037)2.52949178
168atrial septum morphogenesis (GO:0060413)2.52473151
169positive regulation of heart growth (GO:0060421)2.52334792
170extracellular fibril organization (GO:0043206)2.52297660
171mitotic nuclear envelope disassembly (GO:0007077)2.52258872
172negative regulation of embryonic development (GO:0045992)2.52258014
173craniofacial suture morphogenesis (GO:0097094)2.52242299
174nuclear pore organization (GO:0006999)2.51140663
175histone H2B ubiquitination (GO:0033523)2.48686722
176embryonic cranial skeleton morphogenesis (GO:0048701)2.48655279
177regulation of establishment or maintenance of cell polarity (GO:0032878)2.46016295
178sister chromatid cohesion (GO:0007062)2.45454801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.71913144
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.65988010
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.93037401
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43949814
5* CBX2_27304074_Chip-Seq_ESCs_Mouse3.14406573
6AR_21909140_ChIP-Seq_LNCAP_Human3.09996665
7EP300_21415370_ChIP-Seq_HL-1_Mouse3.09989269
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97279720
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.93765190
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.90993919
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.83442913
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78921685
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.78243305
14FUS_26573619_Chip-Seq_HEK293_Human2.70509995
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.68332668
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.59950119
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.55850192
18* ISL1_27105846_Chip-Seq_CPCs_Mouse2.52656643
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30249909
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27936929
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27936929
22SALL4_18804426_ChIP-ChIP_XEN_Mouse2.27740979
23MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.25260652
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.20924113
25ESR1_20079471_ChIP-ChIP_T-47D_Human2.20224153
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12073575
27GBX2_23144817_ChIP-Seq_PC3_Human2.10930453
28ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04969739
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.04929907
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99746163
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98659656
32* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94861304
33TAF15_26573619_Chip-Seq_HEK293_Human1.94061734
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93962109
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91268415
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89062314
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87659581
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82658637
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.76864682
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76073145
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.74728890
42* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70983775
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.70476999
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68720893
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67632711
46CJUN_26792858_Chip-Seq_BT549_Human1.63637075
47* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62873734
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.59853329
49* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59387530
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58362612
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57542827
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.56874326
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51616413
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50551116
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.48648783
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47760497
57AHR_22903824_ChIP-Seq_MCF-7_Human1.47431284
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.46394318
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45498561
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42735954
61PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42273603
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39791260
63* P300_19829295_ChIP-Seq_ESCs_Human1.38636439
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38560521
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38346347
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.36314977
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36245813
68IGF1R_20145208_ChIP-Seq_DFB_Human1.34035177
69BRD4_25478319_ChIP-Seq_HGPS_Human1.33482140
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32959622
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32957448
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.32637503
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31754089
74AR_21572438_ChIP-Seq_LNCaP_Human1.31134237
75SMAD4_21799915_ChIP-Seq_A2780_Human1.30679131
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.30094226
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29763344
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29142538
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.29013716
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28559459
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28559459
82* STAT3_23295773_ChIP-Seq_U87_Human1.28068323
83MYC_18940864_ChIP-ChIP_HL60_Human1.27611492
84EZH2_22144423_ChIP-Seq_EOC_Human1.25907233
85ER_23166858_ChIP-Seq_MCF-7_Human1.25816752
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25517340
87GATA4_21415370_ChIP-Seq_HL-1_Mouse1.23423636
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22657563
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22288562
90CLOCK_20551151_ChIP-Seq_293T_Human1.22148926
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21832258
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21434316
93* EZH2_27294783_Chip-Seq_ESCs_Mouse1.21373817
94* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19141194
95RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18911412
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18350104
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.18286425
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17041101
99* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16364539
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16063023
101* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14967097
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.14911526
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14412061
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14332758
105ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14265236
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13851058
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13415105
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11294887
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.11175926
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.11175926
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11073950
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10396893
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09861180
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08932974
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07633741
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06958529
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06821814
118TP53_16413492_ChIP-PET_HCT116_Human1.06726313
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06067793
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05427820
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05308947
122GATA1_26923725_Chip-Seq_HPCs_Mouse1.05171453
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04216781
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02519358
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02357024
126RUNX2_22187159_ChIP-Seq_PCA_Human1.01333464
127ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01259850
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01159507
129EWS_26573619_Chip-Seq_HEK293_Human1.00559654
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00228550
131BCAT_22108803_ChIP-Seq_LS180_Human1.00085077
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97355589
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97278556
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95834597
135* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91545197
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90866269
137GF1B_26923725_Chip-Seq_HPCs_Mouse0.90639475
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90487024
139TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90375459
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.90334766
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.90280144
142PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89599098
143* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89073028
144MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86451964
145* TP53_20018659_ChIP-ChIP_R1E_Mouse0.85058685
146TTF2_22483619_ChIP-Seq_HELA_Human0.83977259
147KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83623614
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83623614
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83623614
150* RNF2_27304074_Chip-Seq_NSC_Mouse0.83175095
151MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82629390
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82492547
153MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82335114
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82033696
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81524036
156TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81418867
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81334125
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80907259
159TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80116170
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79535433
161ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78963624
162TP53_18474530_ChIP-ChIP_U2OS_Human0.77892644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.22871683
2MP0003122_maternal_imprinting3.46719092
3MP0003121_genomic_imprinting3.27173068
4MP0002102_abnormal_ear_morphology3.11693042
5MP0009384_cardiac_valve_regurgitation2.96227844
6MP0005451_abnormal_body_composition2.65498033
7MP0003385_abnormal_body_wall2.33153351
8MP0002160_abnormal_reproductive_system2.32392908
9MP0010030_abnormal_orbit_morphology2.32308417
10MP0003937_abnormal_limbs/digits/tail_de2.22571434
11MP0002108_abnormal_muscle_morphology2.19867400
12MP0005187_abnormal_penis_morphology2.12578732
13MP0005257_abnormal_intraocular_pressure2.06786893
14MP0003942_abnormal_urinary_system2.05492596
15MP0010368_abnormal_lymphatic_system2.04988773
16MP0004272_abnormal_basement_membrane2.02488316
17MP0008438_abnormal_cutaneous_collagen2.00976328
18MP0002249_abnormal_larynx_morphology1.91207687
19MP0003718_maternal_effect1.90799071
20MP0000537_abnormal_urethra_morphology1.89696760
21MP0003693_abnormal_embryo_hatching1.85801230
22MP0003567_abnormal_fetal_cardiomyocyte1.85655225
23MP0004084_abnormal_cardiac_muscle1.84894448
24MP0009250_abnormal_appendicular_skeleto1.81417607
25MP0003119_abnormal_digestive_system1.79472718
26MP0000516_abnormal_urinary_system1.67863128
27MP0005367_renal/urinary_system_phenotyp1.67863128
28MP0003315_abnormal_perineum_morphology1.65918119
29MP0000534_abnormal_ureter_morphology1.65345810
30MP0003115_abnormal_respiratory_system1.63759699
31MP0002282_abnormal_trachea_morphology1.60882196
32MP0009053_abnormal_anal_canal1.60651026
33MP0008057_abnormal_DNA_replication1.60460932
34MP0006138_congestive_heart_failure1.59320142
35MP0001346_abnormal_lacrimal_gland1.58662650
36MP0002127_abnormal_cardiovascular_syste1.58000131
37MP0003705_abnormal_hypodermis_morpholog1.55592743
38MP0000767_abnormal_smooth_muscle1.53130047
39MP0003077_abnormal_cell_cycle1.52620800
40MP0000383_abnormal_hair_follicle1.51845644
41MP0004957_abnormal_blastocyst_morpholog1.50098354
42MP0002653_abnormal_ependyma_morphology1.48475185
43MP0002295_abnormal_pulmonary_circulatio1.48091710
44MP0001958_emphysema1.45226069
45MP0000462_abnormal_digestive_system1.44879926
46MP0003111_abnormal_nucleus_morphology1.44305798
47MP0010094_abnormal_chromosome_stability1.43426356
48MP0008932_abnormal_embryonic_tissue1.43013195
49MP0003890_abnormal_embryonic-extraembry1.42926847
50MP0003566_abnormal_cell_adhesion1.41558069
51MP0001661_extended_life_span1.41219496
52MP0003935_abnormal_craniofacial_develop1.40983668
53MP0000749_muscle_degeneration1.40868509
54MP0001672_abnormal_embryogenesis/_devel1.38953787
55MP0005380_embryogenesis_phenotype1.38953787
56MP0003279_aneurysm1.38566909
57MP0001730_embryonic_growth_arrest1.37722521
58MP0002084_abnormal_developmental_patter1.36371497
59MP0003943_abnormal_hepatobiliary_system1.32539516
60MP0005275_abnormal_skin_tensile1.32238556
61MP0002085_abnormal_embryonic_tissue1.32160932
62MP0003828_pulmonary_edema1.32099758
63MP0000428_abnormal_craniofacial_morphol1.28687229
64MP0008877_abnormal_DNA_methylation1.27924673
65MP0000049_abnormal_middle_ear1.27458105
66MP0005389_reproductive_system_phenotype1.27399083
67MP0002114_abnormal_axial_skeleton1.26780832
68MP0003941_abnormal_skin_development1.26511953
69MP0002088_abnormal_embryonic_growth/wei1.25059596
70MP0008995_early_reproductive_senescence1.25008427
71MP0002925_abnormal_cardiovascular_devel1.24575335
72MP0003984_embryonic_growth_retardation1.24236091
73MP0002932_abnormal_joint_morphology1.23143781
74MP0001697_abnormal_embryo_size1.22164833
75MP0002233_abnormal_nose_morphology1.18666695
76MP0002234_abnormal_pharynx_morphology1.17680520
77MP0003755_abnormal_palate_morphology1.17019298
78MP0010630_abnormal_cardiac_muscle1.16820799
79MP0000733_abnormal_muscle_development1.16709544
80MP0005503_abnormal_tendon_morphology1.16118054
81MP0000566_synostosis1.15807929
82MP0005508_abnormal_skeleton_morphology1.13019332
83MP0000266_abnormal_heart_morphology1.12830723
84MP0005385_cardiovascular_system_phenoty1.12334094
85MP0001544_abnormal_cardiovascular_syste1.12334094
86MP0002972_abnormal_cardiac_muscle1.11471773
87MP0002086_abnormal_extraembryonic_tissu1.10783890
88MP0001119_abnormal_female_reproductive1.10595174
89MP0001177_atelectasis1.10376876
90MP0003950_abnormal_plasma_membrane1.10206187
91MP0001879_abnormal_lymphatic_vessel1.09944392
92MP0004145_abnormal_muscle_electrophysio1.08893492
93MP0000432_abnormal_head_morphology1.08647322
94MP0004197_abnormal_fetal_growth/weight/1.08624546
95MP0004782_abnormal_surfactant_physiolog1.07215139
96MP0001175_abnormal_lung_morphology1.06759056
97MP0000427_abnormal_hair_cycle1.06677882
98MP0001614_abnormal_blood_vessel1.06512848
99MP0004087_abnormal_muscle_fiber1.06114651
100MP0000762_abnormal_tongue_morphology1.06004413
101MP0005623_abnormal_meninges_morphology1.04411855
102MP0004036_abnormal_muscle_relaxation1.01816668
103MP0003221_abnormal_cardiomyocyte_apopto1.00994318
104MP0002116_abnormal_craniofacial_bone1.00697588
105MP0002111_abnormal_tail_morphology1.00619352
106MP0002697_abnormal_eye_size1.00131157
107MP0002115_abnormal_skeleton_extremities0.98835952
108MP0005248_abnormal_Harderian_gland0.96933335
109MP0000163_abnormal_cartilage_morphology0.96885034
110MP0005620_abnormal_muscle_contractility0.96840438
111MP0003283_abnormal_digestive_organ0.96412698
112MP0002938_white_spotting0.95601423
113MP0001664_abnormal_digestion0.95560147
114MP0004510_myositis0.95550420
115MP0000470_abnormal_stomach_morphology0.94881645
116MP0009697_abnormal_copulation0.94841895
117MP0001299_abnormal_eye_distance/0.94822627
118MP0002128_abnormal_blood_circulation0.94301831
119MP0003137_abnormal_impulse_conducting0.93980637
120MP0004133_heterotaxia0.93693895
121MP0001286_abnormal_eye_development0.93075078
122MP0008775_abnormal_heart_ventricle0.92847293
123MP0004085_abnormal_heartbeat0.92474178
124MP0009703_decreased_birth_body0.89651515
125MP0002109_abnormal_limb_morphology0.89542017
126MP0000013_abnormal_adipose_tissue0.88826036
127MP0003786_premature_aging0.88150848
128MP0002177_abnormal_outer_ear0.87432876
129MP0006054_spinal_hemorrhage0.83739764
130MP0003699_abnormal_female_reproductive0.83286648
131MP0002210_abnormal_sex_determination0.79596036
132MP0003938_abnormal_ear_development0.78755427
133MP0010678_abnormal_skin_adnexa0.78000200
134MP0003936_abnormal_reproductive_system0.76414861
135MP0000631_abnormal_neuroendocrine_gland0.75014227
136MP0000538_abnormal_urinary_bladder0.73086053
137MP0010386_abnormal_urinary_bladder0.69305438
138MP0002877_abnormal_melanocyte_morpholog0.69267659
139MP0000653_abnormal_sex_gland0.68457301
140MP0000681_abnormal_thyroid_gland0.68124516
141MP0004134_abnormal_chest_morphology0.65840656
142MP0001145_abnormal_male_reproductive0.65739434
143MP0005388_respiratory_system_phenotype0.65439128
144MP0002133_abnormal_respiratory_system0.65439128
145MP0005646_abnormal_pituitary_gland0.63894808

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)4.67489517
2Shawl scrotum (HP:0000049)3.88944699
3Vascular tortuosity (HP:0004948)3.75542936
4Pulmonary artery stenosis (HP:0004415)3.41524813
5Double outlet right ventricle (HP:0001719)3.26072092
6Congenital malformation of the right heart (HP:0011723)3.26072092
7Abnormality of the fetal cardiovascular system (HP:0010948)3.26029459
8Abnormal umbilical cord blood vessels (HP:0011403)3.26029459
9Single umbilical artery (HP:0001195)3.26029459
10Midline defect of the nose (HP:0004122)3.15403358
11Soft skin (HP:0000977)3.07051241
12Renal duplication (HP:0000075)3.04801662
13Patellar aplasia (HP:0006443)3.04081758
14Cutaneous finger syndactyly (HP:0010554)3.03298292
15Protrusio acetabuli (HP:0003179)2.94571603
16Shallow orbits (HP:0000586)2.94347536
17Hepatoblastoma (HP:0002884)2.92062440
18Aplasia/Hypoplasia of the patella (HP:0006498)2.90067622
19Bifid tongue (HP:0010297)2.85076645
20Breast hypoplasia (HP:0003187)2.84053082
21Diastasis recti (HP:0001540)2.83285863
22Aortic dissection (HP:0002647)2.72881497
23Short hallux (HP:0010109)2.70660788
24Bicornuate uterus (HP:0000813)2.67685388
25Male infertility (HP:0003251)2.66869602
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65440420
27Short 4th metacarpal (HP:0010044)2.65440420
28Exercise-induced muscle cramps (HP:0003710)2.65224703
29Adrenal hypoplasia (HP:0000835)2.63326226
30Embryonal renal neoplasm (HP:0011794)2.63049143
31Follicular hyperkeratosis (HP:0007502)2.57329406
32Nephroblastoma (Wilms tumor) (HP:0002667)2.54013615
33Cutaneous syndactyly (HP:0012725)2.45345286
34Osteomalacia (HP:0002749)2.44464297
35Volvulus (HP:0002580)2.44407817
36Arterial tortuosity (HP:0005116)2.42377741
37Bell-shaped thorax (HP:0001591)2.42325557
38Broad toe (HP:0001837)2.42198205
39Birth length less than 3rd percentile (HP:0003561)2.41264910
40Hypoplastic left heart (HP:0004383)2.37623314
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.37000304
42Preaxial foot polydactyly (HP:0001841)2.31060673
43Ectopic kidney (HP:0000086)2.30936604
44Abnormality of the 4th metacarpal (HP:0010012)2.29155414
45Supernumerary spleens (HP:0009799)2.28654443
46Subaortic stenosis (HP:0001682)2.27321838
47Abnormality of the left ventricular outflow tract (HP:0011103)2.27321838
48Flat capital femoral epiphysis (HP:0003370)2.26512419
49Camptodactyly of toe (HP:0001836)2.25799408
50Septate vagina (HP:0001153)2.25539479
51Transposition of the great arteries (HP:0001669)2.25347661
52Abnormal connection of the cardiac segments (HP:0011545)2.25347661
53Abnormal ventriculo-arterial connection (HP:0011563)2.25347661
54Abnormality of incisor morphology (HP:0011063)2.24663508
55Meckel diverticulum (HP:0002245)2.23728653
56Abnormal lung lobation (HP:0002101)2.22563184
57Wide anterior fontanel (HP:0000260)2.21716147
58Abnormality of the phalanges of the hallux (HP:0010057)2.18822197
59Duplication of thumb phalanx (HP:0009942)2.17368943
60Premature rupture of membranes (HP:0001788)2.14931003
61Short middle phalanx of the 5th finger (HP:0004220)2.13369485
62Lip pit (HP:0100267)2.13160596
63Abnormality of the middle phalanges of the toes (HP:0010183)2.12583861
64Morphological abnormality of the middle ear (HP:0008609)2.12235839
65Chromsome breakage (HP:0040012)2.12199539
66Rectal prolapse (HP:0002035)2.11183619
67Asymmetry of the thorax (HP:0001555)2.10878077
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.10675973
69Lipoatrophy (HP:0100578)2.10662233
70Infantile muscular hypotonia (HP:0008947)2.09267101
71Deviation of the thumb (HP:0009603)2.07653013
72Bladder diverticulum (HP:0000015)2.06592687
73Papillary thyroid carcinoma (HP:0002895)2.06260485
74Microglossia (HP:0000171)2.05462510
75Persistence of primary teeth (HP:0006335)2.05178497
76Increased corneal curvature (HP:0100692)2.04885355
77Keratoconus (HP:0000563)2.04885355
78Patent foramen ovale (HP:0001655)2.03659289
79Wrist flexion contracture (HP:0001239)2.03455706
80Absent radius (HP:0003974)2.02653771
81Atrial fibrillation (HP:0005110)2.00938046
82Renal dysplasia (HP:0000110)2.00912728
83Gonadotropin excess (HP:0000837)2.00573083
84Abnormality of the ileum (HP:0001549)2.00330470
85Abnormality of the parietal bone (HP:0002696)2.00217974
86Broad palm (HP:0001169)1.99973063
87Long toe (HP:0010511)1.97557925
88Periauricular skin pits (HP:0100277)1.96726577
89Preauricular pit (HP:0004467)1.96726577
90Abnormality of the renal collecting system (HP:0004742)1.96066065
91Truncal obesity (HP:0001956)1.94554606
92Absent phalangeal crease (HP:0006109)1.93786196
93Aplasia involving bones of the extremities (HP:0009825)1.93056886
94Aplasia involving bones of the upper limbs (HP:0009823)1.93056886
95Aplasia of the phalanges of the hand (HP:0009802)1.93056886
96Aneurysm (HP:0002617)1.91774884
97Submucous cleft hard palate (HP:0000176)1.90259988
98Abnormality of the pulmonary veins (HP:0011718)1.90215209
99Aplasia/Hypoplasia of the breasts (HP:0010311)1.89961316
100Hypoplastic heart (HP:0001961)1.89884587
101Steppage gait (HP:0003376)1.89538687
102Increased number of teeth (HP:0011069)1.89161592
103Aplasia involving forearm bones (HP:0009822)1.88931388
104Absent forearm bone (HP:0003953)1.88931388
105Unilateral renal agenesis (HP:0000122)1.88741002
106Occipital encephalocele (HP:0002085)1.88691040
107Broad hallux (HP:0010055)1.88665900
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.88097324
109Abnormality of the umbilical cord (HP:0010881)1.87521736
110Ankle contracture (HP:0006466)1.87353844
111Short 5th finger (HP:0009237)1.87316744
112Chorioretinal atrophy (HP:0000533)1.86150732
113Primary atrial arrhythmia (HP:0001692)1.86089283
114Coarctation of aorta (HP:0001680)1.85685249
115Abnormality of the distal phalanges of the toes (HP:0010182)1.83543451
116Abnormality of dentin (HP:0010299)1.83538525
117Absent frontal sinuses (HP:0002688)1.82310073
118Duplicated collecting system (HP:0000081)1.81987896
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80840612
120Hypoplasia of the iris (HP:0007676)1.80831588
121Breast aplasia (HP:0100783)1.80551228
122Abnormality of chromosome segregation (HP:0002916)1.79607112
123Abnormal number of incisors (HP:0011064)1.77454712
124Abnormality of the incisor (HP:0000676)1.77183842
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.75840063
126Bicuspid aortic valve (HP:0001647)1.75592342
127Colon cancer (HP:0003003)1.75045430
128Supraventricular arrhythmia (HP:0005115)1.74727916
129Partial duplication of thumb phalanx (HP:0009944)1.74620563
130Ulnar bowing (HP:0003031)1.74214506
131Macroorchidism (HP:0000053)1.74166638
132Joint contractures involving the joints of the feet (HP:0100492)1.73788319
133Flexion contracture of toe (HP:0005830)1.73788319
134Supraventricular tachycardia (HP:0004755)1.73676356
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.73338200
136Spondylolisthesis (HP:0003302)1.72343480
137Lymphangioma (HP:0100764)1.72338998
138Aplasia/Hypoplasia of the lens (HP:0008063)1.71760225
139Atrioventricular canal defect (HP:0006695)1.71593307
140Cerebral aneurysm (HP:0004944)1.71017995
141Tarsal synostosis (HP:0008368)1.70599716
142Sudden death (HP:0001699)1.70469641
143Broad thumb (HP:0011304)1.69960272
144Sandal gap (HP:0001852)1.69783638
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69580667
146Knee flexion contracture (HP:0006380)1.69567385
147Abnormal pancreas size (HP:0012094)1.69152409
148Short clavicles (HP:0000894)1.68985490
149Skin pits (HP:0100276)1.68974745
150Mitral valve prolapse (HP:0001634)1.67981418
151Aplasia cutis congenita (HP:0001057)1.67860813
152Partial duplication of the phalanx of hand (HP:0009999)1.66974075
153Carpal synostosis (HP:0009702)1.66442025
154Deep philtrum (HP:0002002)1.66095649
155Abnormal biliary tract physiology (HP:0012439)1.66016398
156Bile duct proliferation (HP:0001408)1.66016398
157Spinal rigidity (HP:0003306)1.65934106
158Anterior segment dysgenesis (HP:0007700)1.65871749
159Striae distensae (HP:0001065)1.65694164
160Broad metatarsal (HP:0001783)1.64842320
161Hypoplastic labia majora (HP:0000059)1.63812625
162Abnormality of the ischium (HP:0003174)1.63801092
163Vaginal atresia (HP:0000148)1.62828086
164Arteriovenous malformation (HP:0100026)1.62518501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.72469192
2PLK44.56142477
3LATS23.88199632
4LATS13.84111488
5PNCK3.58512575
6ZAK3.38463046
7STK38L3.31743085
8MYLK2.88115409
9FRK2.62954209
10ICK2.55632167
11TTK2.50756945
12OBSCN2.48197703
13CASK2.30893663
14CAMK1G2.20754001
15ERBB42.16393624
16MAP3K62.06915349
17DMPK1.95133918
18GRK11.92208418
19TRIB31.88328235
20CDK81.85397946
21EPHB21.84941646
22MOS1.84794563
23PRKD31.78796589
24STK241.78328794
25CDC71.76295797
26BRAF1.63780590
27STK31.56258896
28BMPR1B1.54133331
29PDGFRA1.53907576
30EEF2K1.48286635
31NEK91.46091747
32ILK1.43248837
33BUB11.39388135
34NEK21.38900486
35PIK3CA1.37586454
36AKT31.33962680
37WNK11.32569142
38KSR21.31156803
39CHEK21.31037972
40NEK61.24573814
41MELK1.24236843
42STK101.22712210
43STK161.18638841
44NUAK11.18084035
45BMPR21.14342025
46FGFR21.13013517
47MAP3K81.11111496
48LIMK11.07972265
49PLK11.04864390
50DYRK31.03806201
51RAF11.00366572
52CLK10.99228407
53TTN0.98190789
54AURKB0.96646225
55ROCK10.96396594
56CDC42BPA0.95664395
57ADRBK20.95057926
58PLK30.94754498
59TRIM280.94241274
60INSRR0.93784142
61MAPK130.93102893
62PKN20.92027974
63CDK30.91293132
64PAK20.91066677
65SRPK10.88832304
66PBK0.88088465
67CAMK1D0.87780066
68TAOK10.87746646
69SGK20.87411928
70BRD40.84139378
71DYRK20.82930096
72TGFBR10.81688882
73RPS6KA60.78951674
74TRPM70.76444313
75PTK2B0.75529584
76MAP3K100.75359160
77ERBB30.72883760
78PAK10.71776984
79CDK70.70545165
80ADRBK10.70089659
81KDR0.68796210
82TIE10.68360509
83TESK10.68238963
84RPS6KB10.67977985
85RPS6KC10.67166455
86RPS6KL10.67166455
87TGFBR20.67148169
88STK380.66841180
89PLK20.66330144
90PTK20.66297695
91FGFR10.66254552
92WNK30.66093170
93CAMK40.65621089
94AKT20.64117437
95NEK10.63090194
96AURKA0.62811644
97KSR10.61837989
98ATR0.61653118
99RPS6KA20.61245086
100RPS6KB20.60903378
101PAK30.58873607
102MAP3K40.58763369
103CDK90.58621834
104DDR20.57496545
105STK390.56500642
106CHUK0.56465156
107CHEK10.56423615
108PIK3CG0.52707662
109MAP3K130.52592265
110CSNK1G20.52535036
111PRKD20.52175656
112ACVR1B0.51240400
113CSNK1G10.49415726
114BRSK20.47888504
115ATM0.47494393
116TNIK0.47339997
117MET0.46545275
118STK40.46060270
119GRK50.45661360
120PDGFRB0.44099605
121MAP2K20.43697495
122PRKAA20.42977700
123MUSK0.42147647
124MAP3K20.41628354
125BCR0.38034977
126MTOR0.37953635
127MAP2K10.37915312
128MAP3K90.37750167
129RPS6KA50.37719919
130MAP3K30.37630925
131MAPKAPK30.37332516
132FLT30.37298203
133SGK4940.36430313
134SGK2230.36430313
135ARAF0.35452842
136SGK30.35110090
137PRKD10.35018560
138CDK40.34709790
139MAPK100.34138201
140CDK120.34135357
141WEE10.32387894
142TAOK30.32038231
143ROCK20.31806701
144CDK10.30971400
145PAK60.30952734
146PAK40.29214035
147MKNK10.29028619
148CDK20.28924584
149CSNK1A1L0.28432742
150MKNK20.28336486
151PRKCI0.27710734
152RPS6KA40.27672987
153LRRK20.26972904
154RET0.26792254

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.53894027
2TGF-beta signaling pathway_Homo sapiens_hsa043503.47677039
3Hippo signaling pathway_Homo sapiens_hsa043903.13644037
4Basal cell carcinoma_Homo sapiens_hsa052172.80810243
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.54697214
6Hedgehog signaling pathway_Homo sapiens_hsa043402.27081208
7Dilated cardiomyopathy_Homo sapiens_hsa054142.22172605
8RNA degradation_Homo sapiens_hsa030182.19663385
9Basal transcription factors_Homo sapiens_hsa030222.18618362
10Adherens junction_Homo sapiens_hsa045202.15563680
11Selenocompound metabolism_Homo sapiens_hsa004502.12031541
12Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.03421751
13Mismatch repair_Homo sapiens_hsa034302.00815219
14RNA transport_Homo sapiens_hsa030131.99511245
15MicroRNAs in cancer_Homo sapiens_hsa052061.98196113
16Oocyte meiosis_Homo sapiens_hsa041141.95555086
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93556358
18DNA replication_Homo sapiens_hsa030301.93467577
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.89862468
20Homologous recombination_Homo sapiens_hsa034401.85085079
21Tight junction_Homo sapiens_hsa045301.79249843
22ECM-receptor interaction_Homo sapiens_hsa045121.77121952
23Base excision repair_Homo sapiens_hsa034101.76387846
24Focal adhesion_Homo sapiens_hsa045101.71357658
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68256477
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66511937
27Non-homologous end-joining_Homo sapiens_hsa034501.66443326
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.66402174
29Ovarian steroidogenesis_Homo sapiens_hsa049131.65677443
30Cardiac muscle contraction_Homo sapiens_hsa042601.64564482
31Nucleotide excision repair_Homo sapiens_hsa034201.57583385
32Wnt signaling pathway_Homo sapiens_hsa043101.56833890
33mRNA surveillance pathway_Homo sapiens_hsa030151.52005851
34Sulfur relay system_Homo sapiens_hsa041221.49663399
35ABC transporters_Homo sapiens_hsa020101.44962893
36Proteoglycans in cancer_Homo sapiens_hsa052051.43545855
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36080623
38Circadian rhythm_Homo sapiens_hsa047101.31674667
39Fanconi anemia pathway_Homo sapiens_hsa034601.29905121
40Bladder cancer_Homo sapiens_hsa052191.27209416
41Small cell lung cancer_Homo sapiens_hsa052221.22771669
42HTLV-I infection_Homo sapiens_hsa051661.22086163
43p53 signaling pathway_Homo sapiens_hsa041151.20889562
44Nicotine addiction_Homo sapiens_hsa050331.20126387
45Spliceosome_Homo sapiens_hsa030401.18907247
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16782047
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.16662580
48Pathways in cancer_Homo sapiens_hsa052001.12659144
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09456013
50Endometrial cancer_Homo sapiens_hsa052131.08900887
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.08331899
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04603901
53Taste transduction_Homo sapiens_hsa047421.03596758
54Pancreatic cancer_Homo sapiens_hsa052121.03249719
55Melanogenesis_Homo sapiens_hsa049161.01507271
56Melanoma_Homo sapiens_hsa052181.01496652
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01488139
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98066429
59Colorectal cancer_Homo sapiens_hsa052100.96749559
60Choline metabolism in cancer_Homo sapiens_hsa052310.96199164
61HIF-1 signaling pathway_Homo sapiens_hsa040660.95501910
62One carbon pool by folate_Homo sapiens_hsa006700.94618994
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92663274
64Calcium signaling pathway_Homo sapiens_hsa040200.89582371
65Axon guidance_Homo sapiens_hsa043600.88630709
66RNA polymerase_Homo sapiens_hsa030200.88013130
67Lysine degradation_Homo sapiens_hsa003100.87342328
68Notch signaling pathway_Homo sapiens_hsa043300.85398018
69Rap1 signaling pathway_Homo sapiens_hsa040150.81672313
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81453757
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80746478
72Morphine addiction_Homo sapiens_hsa050320.78680268
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77718683
74AMPK signaling pathway_Homo sapiens_hsa041520.75910426
75Circadian entrainment_Homo sapiens_hsa047130.74089130
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.73972344
77Prostate cancer_Homo sapiens_hsa052150.73616905
78GnRH signaling pathway_Homo sapiens_hsa049120.72698767
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71937049
80Thyroid cancer_Homo sapiens_hsa052160.71176874
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70586057
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70225837
83Renin secretion_Homo sapiens_hsa049240.69668321
84Amoebiasis_Homo sapiens_hsa051460.68516683
85Glucagon signaling pathway_Homo sapiens_hsa049220.68218462
86Renal cell carcinoma_Homo sapiens_hsa052110.67903663
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67557016
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64657707
89Chronic myeloid leukemia_Homo sapiens_hsa052200.60935785
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.59340889
91Biosynthesis of amino acids_Homo sapiens_hsa012300.58569755
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58534039
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57910265
94Ras signaling pathway_Homo sapiens_hsa040140.57786916
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56369275
96Tryptophan metabolism_Homo sapiens_hsa003800.56009663
97N-Glycan biosynthesis_Homo sapiens_hsa005100.54821881
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.54692047
99Propanoate metabolism_Homo sapiens_hsa006400.54181906
100Gap junction_Homo sapiens_hsa045400.53347887
101Phototransduction_Homo sapiens_hsa047440.53299220
102mTOR signaling pathway_Homo sapiens_hsa041500.52840241
103FoxO signaling pathway_Homo sapiens_hsa040680.52022772
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51313817
105Dorso-ventral axis formation_Homo sapiens_hsa043200.49891750
106MAPK signaling pathway_Homo sapiens_hsa040100.49742009
107ErbB signaling pathway_Homo sapiens_hsa040120.49371981
108Sphingolipid metabolism_Homo sapiens_hsa006000.49362299
109Type II diabetes mellitus_Homo sapiens_hsa049300.48637883
110Glycerolipid metabolism_Homo sapiens_hsa005610.48434906
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47484814
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46951955
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46585049
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46099454
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.45179777
116Serotonergic synapse_Homo sapiens_hsa047260.43504645
117Protein digestion and absorption_Homo sapiens_hsa049740.43397073
118Huntingtons disease_Homo sapiens_hsa050160.42291521
119Pyrimidine metabolism_Homo sapiens_hsa002400.39052145
120Viral myocarditis_Homo sapiens_hsa054160.37446599
121Long-term depression_Homo sapiens_hsa047300.36924841
122Purine metabolism_Homo sapiens_hsa002300.35651109
123Oxytocin signaling pathway_Homo sapiens_hsa049210.35143127
124Viral carcinogenesis_Homo sapiens_hsa052030.34871467
125Platelet activation_Homo sapiens_hsa046110.31658323
126Ether lipid metabolism_Homo sapiens_hsa005650.29895167
127Arachidonic acid metabolism_Homo sapiens_hsa005900.28624356
128Linoleic acid metabolism_Homo sapiens_hsa005910.27892432
129Glioma_Homo sapiens_hsa052140.27401340
130Estrogen signaling pathway_Homo sapiens_hsa049150.26100175
131cAMP signaling pathway_Homo sapiens_hsa040240.24354873
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.24089515
133Carbon metabolism_Homo sapiens_hsa012000.23811840
134Non-small cell lung cancer_Homo sapiens_hsa052230.23046882
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21369675

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