PRDM14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by miRNA (GO:0060964)5.52613090
2regulation of gene silencing by RNA (GO:0060966)5.52613090
3regulation of posttranscriptional gene silencing (GO:0060147)5.52613090
4establishment of integrated proviral latency (GO:0075713)5.02054672
5protein K6-linked ubiquitination (GO:0085020)4.99652825
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.91940150
7regulation of translation, ncRNA-mediated (GO:0045974)4.91940150
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.91940150
9formation of translation preinitiation complex (GO:0001731)4.90963018
10regulation of histone H3-K9 methylation (GO:0051570)4.72298969
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.71539608
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.71539608
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.65573709
14protein localization to kinetochore (GO:0034501)4.62445770
15DNA replication checkpoint (GO:0000076)4.45299741
16L-serine metabolic process (GO:0006563)4.44354874
17nuclear pore organization (GO:0006999)4.43716030
18histone H4-K12 acetylation (GO:0043983)4.30805392
19single strand break repair (GO:0000012)4.30480589
20DNA replication initiation (GO:0006270)4.27541179
21nuclear pore complex assembly (GO:0051292)4.27182701
22DNA replication-dependent nucleosome assembly (GO:0006335)4.26617894
23DNA replication-dependent nucleosome organization (GO:0034723)4.26617894
24mitotic sister chromatid segregation (GO:0000070)4.25888741
25ribosome biogenesis (GO:0042254)4.22842061
26mitotic metaphase plate congression (GO:0007080)4.18792796
27regulation of helicase activity (GO:0051095)4.15308754
28heterochromatin organization (GO:0070828)4.05330115
29regulation of telomere maintenance via telomerase (GO:0032210)4.01565666
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.00142457
31DNA unwinding involved in DNA replication (GO:0006268)3.90705155
32transcription from mitochondrial promoter (GO:0006390)3.89970150
33replication fork processing (GO:0031297)3.89786480
34DNA strand elongation involved in DNA replication (GO:0006271)3.88948827
35chromatin remodeling at centromere (GO:0031055)3.87386450
36determination of adult lifespan (GO:0008340)3.87298156
37cell fate commitment involved in formation of primary germ layer (GO:0060795)3.84381635
38regulation of cell fate specification (GO:0042659)3.83980518
39daunorubicin metabolic process (GO:0044597)3.81596488
40polyketide metabolic process (GO:0030638)3.81596488
41doxorubicin metabolic process (GO:0044598)3.81596488
42negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.81047897
43mitotic nuclear envelope disassembly (GO:0007077)3.77461201
44lung-associated mesenchyme development (GO:0060484)3.72447798
45establishment of viral latency (GO:0019043)3.66675096
46cullin deneddylation (GO:0010388)3.66666920
47mitochondrial DNA metabolic process (GO:0032042)3.65387875
48DNA strand elongation (GO:0022616)3.64761397
49CENP-A containing nucleosome assembly (GO:0034080)3.63225473
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.62993339
51regulation of mitotic spindle checkpoint (GO:1903504)3.62020098
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62020098
53negative regulation of telomerase activity (GO:0051974)3.61624925
54nucleobase biosynthetic process (GO:0046112)3.56877723
55protein localization to chromosome, centromeric region (GO:0071459)3.56369263
56anterior/posterior axis specification, embryo (GO:0008595)3.56025275
57histone H4-K8 acetylation (GO:0043982)3.55894458
58histone H4-K5 acetylation (GO:0043981)3.55894458
59sister chromatid segregation (GO:0000819)3.54290319
60lysine metabolic process (GO:0006553)3.52404110
61lysine catabolic process (GO:0006554)3.52404110
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.50706937
63L-alpha-amino acid transmembrane transport (GO:1902475)3.50566234
64pore complex assembly (GO:0046931)3.50462813
65membrane disassembly (GO:0030397)3.49066976
66nuclear envelope disassembly (GO:0051081)3.49066976
67regulation of chromatin silencing (GO:0031935)3.48622017
68intestinal epithelial cell development (GO:0060576)3.44758246
69DNA double-strand break processing (GO:0000729)3.43593313
70embryonic process involved in female pregnancy (GO:0060136)3.43342068
71telomere maintenance via semi-conservative replication (GO:0032201)3.43271223
72regulation of SMAD protein import into nucleus (GO:0060390)3.43267016
73purine nucleobase biosynthetic process (GO:0009113)3.40706211
74metaphase plate congression (GO:0051310)3.39821287
75DNA duplex unwinding (GO:0032508)3.38955792
76DNA geometric change (GO:0032392)3.37300879
77histone exchange (GO:0043486)3.37060918
78positive regulation of chromosome segregation (GO:0051984)3.36350943
79regulation of translation in response to stress (GO:0043555)3.34681216
80ribonucleoprotein complex biogenesis (GO:0022613)3.34383082
81establishment of apical/basal cell polarity (GO:0035089)3.30676293
82proline biosynthetic process (GO:0006561)3.28118815
83DNA replication-independent nucleosome organization (GO:0034724)3.27274769
84DNA replication-independent nucleosome assembly (GO:0006336)3.27274769
85regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.26958543
86rRNA modification (GO:0000154)3.25040811
87regulation of double-strand break repair (GO:2000779)3.25008579
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.24300791
89negative regulation of sister chromatid segregation (GO:0033046)3.24300791
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24300791
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.24300791
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24300791
93IMP metabolic process (GO:0046040)3.23971990
94protein deneddylation (GO:0000338)3.22682412
95regulation of cell fate commitment (GO:0010453)3.22174783
96somite rostral/caudal axis specification (GO:0032525)3.21705625
97mitotic chromosome condensation (GO:0007076)3.20907472
98pre-miRNA processing (GO:0031054)3.19720536
99trophectodermal cell differentiation (GO:0001829)3.19423271
100IMP biosynthetic process (GO:0006188)3.18774444
101chromatin assembly (GO:0031497)3.18520382
102ribosome assembly (GO:0042255)3.16009849
103DNA damage response, detection of DNA damage (GO:0042769)3.11909261
104paraxial mesoderm development (GO:0048339)3.10562144
105negative regulation of gene silencing (GO:0060969)3.09415139
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09009185
107folic acid-containing compound biosynthetic process (GO:0009396)3.05292488
108non-recombinational repair (GO:0000726)3.04147938
109double-strand break repair via nonhomologous end joining (GO:0006303)3.04147938
110ncRNA catabolic process (GO:0034661)3.04108143
111negative regulation of androgen receptor signaling pathway (GO:0060766)3.02102726
112regulation of gene silencing (GO:0060968)3.00931182
113pseudouridine synthesis (GO:0001522)3.00663511
114regulation of translational fidelity (GO:0006450)2.99841673
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.98226578
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98226578
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98226578
118positive regulation of histone H3-K4 methylation (GO:0051571)2.96395397
119mitotic spindle checkpoint (GO:0071174)2.95734247
120nodal signaling pathway (GO:0038092)2.94875179
121positive regulation of SMAD protein import into nucleus (GO:0060391)2.93856343
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.93223556
123ATP-dependent chromatin remodeling (GO:0043044)2.92321462
124negative regulation of chromosome segregation (GO:0051985)2.92049932
125telomere maintenance via recombination (GO:0000722)2.91550161
126telomere maintenance via telomerase (GO:0007004)2.91243342
127female gonad development (GO:0008585)2.91228603
128spindle checkpoint (GO:0031577)2.91142954
129mitotic sister chromatid cohesion (GO:0007064)2.88050445
130mitotic recombination (GO:0006312)2.87233516
131cellular protein complex localization (GO:0034629)2.86652248
132rRNA processing (GO:0006364)2.86420191
133regulation of chromosome segregation (GO:0051983)2.86362950
134rRNA transcription (GO:0009303)2.85232413
135maturation of SSU-rRNA (GO:0030490)2.85151565
136mitotic G1 DNA damage checkpoint (GO:0031571)2.85081199
137maintenance of protein location in nucleus (GO:0051457)2.84901788
138establishment of chromosome localization (GO:0051303)2.84708295
139positive regulation of cell cycle G2/M phase transition (GO:1902751)2.84036206
140positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.84036206
141negative regulation of histone methylation (GO:0031061)2.83636634
142protein complex localization (GO:0031503)2.83380846
143telomere maintenance via telomere lengthening (GO:0010833)2.83091885
144mitochondrial RNA metabolic process (GO:0000959)2.83081946
145regulation of sister chromatid segregation (GO:0033045)2.82885773
146regulation of mitotic sister chromatid separation (GO:0010965)2.82885773
147regulation of mitotic sister chromatid segregation (GO:0033047)2.82885773
148serine family amino acid biosynthetic process (GO:0009070)2.82838692
149DNA demethylation (GO:0080111)2.82718391
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82712160
151regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82712160
152meiotic chromosome segregation (GO:0045132)2.81564591
153kinetochore assembly (GO:0051382)2.81181437
154mitotic spindle assembly checkpoint (GO:0007094)2.76150209
155negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74985778
156regulation of timing of cell differentiation (GO:0048505)2.74572004
157negative regulation of mRNA processing (GO:0050686)2.73762918
158regulation of development, heterochronic (GO:0040034)2.73547094
159notochord development (GO:0030903)2.71149740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02281593
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.41356516
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.41356516
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.41356516
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.61781617
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.42108469
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.14487922
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.03290997
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.99742061
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99304342
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91563187
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.84919292
13TCF3_18692474_ChIP-Seq_MEFs_Mouse2.56279573
14* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.53097179
15NANOG_18555785_ChIP-Seq_MESCs_Mouse2.51360633
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49403841
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.47838112
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.45863954
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40899739
20* SOX2_16153702_ChIP-ChIP_HESCs_Human2.39391626
21* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.35937241
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33201400
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.32060330
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29286877
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24482912
26* NANOG_16153702_ChIP-ChIP_HESCs_Human2.23704879
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15051935
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.06069182
29ZNF274_21170338_ChIP-Seq_K562_Hela2.03736716
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02392960
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.99698945
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99653780
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.95175425
34NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.95104010
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93561620
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.89125451
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.84950460
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83050242
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.82717141
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81861553
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81115518
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.79991720
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79455614
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78142982
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76203927
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76111151
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.75789054
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74904853
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73891245
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72765710
51* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71713848
52POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70352299
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68417603
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67945420
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63698670
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62210813
57XRN2_22483619_ChIP-Seq_HELA_Human1.61515265
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61198150
59SOX2_18692474_ChIP-Seq_MEFs_Mouse1.60473136
60NANOG_18692474_ChIP-Seq_MEFs_Mouse1.57421802
61ELK1_19687146_ChIP-ChIP_HELA_Human1.55829970
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.55488284
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.52919142
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.49294006
65* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.48268293
66* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.47674844
67OCT4_18692474_ChIP-Seq_MEFs_Mouse1.47214310
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47053151
69EWS_26573619_Chip-Seq_HEK293_Human1.46248977
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46162207
71AR_21909140_ChIP-Seq_LNCAP_Human1.43868573
72* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.42362729
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40900154
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.37147573
75* MYC_18940864_ChIP-ChIP_HL60_Human1.36748353
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.36565713
77* P300_19829295_ChIP-Seq_ESCs_Human1.36067480
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33742226
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.32408643
80VDR_22108803_ChIP-Seq_LS180_Human1.31128297
81* FLI1_27457419_Chip-Seq_LIVER_Mouse1.30068970
82* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.29884273
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28217818
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27181078
85FUS_26573619_Chip-Seq_HEK293_Human1.26830284
86VDR_23849224_ChIP-Seq_CD4+_Human1.26636233
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26164863
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.25045413
89GABP_19822575_ChIP-Seq_HepG2_Human1.22221577
90MYC_22102868_ChIP-Seq_BL_Human1.20758585
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19322668
92DCP1A_22483619_ChIP-Seq_HELA_Human1.17825624
93TTF2_22483619_ChIP-Seq_HELA_Human1.17633316
94NANOG_16518401_ChIP-PET_MESCs_Mouse1.17505782
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13664417
96FOXP3_21729870_ChIP-Seq_TREG_Human1.12945762
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.12745978
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12212474
99IRF1_19129219_ChIP-ChIP_H3396_Human1.11866492
100KAP1_27257070_Chip-Seq_ESCs_Mouse1.11306305
101* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09800904
102KDM5A_27292631_Chip-Seq_BREAST_Human1.08289685
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07509413
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07509413
105* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07458953
106* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06500889
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06150199
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03078547
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02928295
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02718687
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02664469
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00608251
113TFEB_21752829_ChIP-Seq_HELA_Human1.00250881
114* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98769839
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98294465
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98081069
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92396870
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92263878
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92150159
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91852600
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91704557
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90612742
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89929694
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87803981
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86051012
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83142156
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80063470
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.79210003
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78311512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.14150929
2MP0004957_abnormal_blastocyst_morpholog4.20957662
3MP0010094_abnormal_chromosome_stability3.63329711
4MP0003111_abnormal_nucleus_morphology3.57420250
5MP0003693_abnormal_embryo_hatching3.41176807
6MP0003806_abnormal_nucleotide_metabolis3.19071161
7MP0008058_abnormal_DNA_repair3.13946289
8MP0004133_heterotaxia3.09106053
9MP0003077_abnormal_cell_cycle3.04981001
10MP0002653_abnormal_ependyma_morphology3.04024752
11MP0003890_abnormal_embryonic-extraembry2.93472264
12MP0003283_abnormal_digestive_organ2.83430200
13MP0009672_abnormal_birth_weight2.70678694
14MP0010352_gastrointestinal_tract_polyps2.61775716
15MP0002277_abnormal_respiratory_mucosa2.40006234
16MP0006292_abnormal_olfactory_placode2.31063289
17MP0000350_abnormal_cell_proliferation2.15495799
18MP0003123_paternal_imprinting2.15186486
19MP0001672_abnormal_embryogenesis/_devel2.13745525
20MP0005380_embryogenesis_phenotype2.13745525
21MP0001730_embryonic_growth_arrest2.13140994
22MP0004264_abnormal_extraembryonic_tissu2.05818727
23MP0008932_abnormal_embryonic_tissue2.04914194
24MP0003787_abnormal_imprinting1.97533757
25MP0002084_abnormal_developmental_patter1.92383257
26MP0002085_abnormal_embryonic_tissue1.87932797
27MP0003136_yellow_coat_color1.83672185
28MP0003984_embryonic_growth_retardation1.83669826
29MP0003119_abnormal_digestive_system1.82957760
30MP0002086_abnormal_extraembryonic_tissu1.82681148
31MP0002088_abnormal_embryonic_growth/wei1.80827278
32MP0001293_anophthalmia1.78979340
33MP0003786_premature_aging1.76779963
34MP0001697_abnormal_embryo_size1.76684445
35MP0010030_abnormal_orbit_morphology1.72290763
36MP0008007_abnormal_cellular_replicative1.71592524
37MP0004197_abnormal_fetal_growth/weight/1.62031972
38MP0003718_maternal_effect1.57169568
39MP0001188_hyperpigmentation1.55853991
40MP0005266_abnormal_metabolism1.49379768
41MP0002697_abnormal_eye_size1.47745686
42MP0002080_prenatal_lethality1.42548453
43MP0001299_abnormal_eye_distance/1.42135379
44MP0001849_ear_inflammation1.39056830
45MP0000537_abnormal_urethra_morphology1.38941061
46MP0003705_abnormal_hypodermis_morpholog1.36990590
47MP0003941_abnormal_skin_development1.34856377
48MP0010307_abnormal_tumor_latency1.34294078
49MP0005075_abnormal_melanosome_morpholog1.32159610
50MP0002938_white_spotting1.29479126
51MP0010234_abnormal_vibrissa_follicle1.29186006
52MP0002751_abnormal_autonomic_nervous1.27589920
53MP0008877_abnormal_DNA_methylation1.25487372
54MP0000049_abnormal_middle_ear1.23858880
55MP0003121_genomic_imprinting1.22341621
56MP0005076_abnormal_cell_differentiation1.20349128
57MP0000490_abnormal_crypts_of1.18400213
58MP0008789_abnormal_olfactory_epithelium1.16824711
59MP0001145_abnormal_male_reproductive1.15265932
60MP0000566_synostosis1.15038715
61MP0009278_abnormal_bone_marrow1.14965533
62MP0002736_abnormal_nociception_after1.14672126
63MP0003878_abnormal_ear_physiology1.13356697
64MP0005377_hearing/vestibular/ear_phenot1.13356697
65MP0003567_abnormal_fetal_cardiomyocyte1.10098575
66MP0002254_reproductive_system_inflammat1.09663381
67MP0000313_abnormal_cell_death1.09222273
68MP0003646_muscle_fatigue1.08938459
69MP0002233_abnormal_nose_morphology1.08759287
70MP0002210_abnormal_sex_determination1.07593398
71MP0001485_abnormal_pinna_reflex1.07009804
72MP0000428_abnormal_craniofacial_morphol1.05747220
73MP0002163_abnormal_gland_morphology1.03194008
74MP0000579_abnormal_nail_morphology1.02698211
75MP0003122_maternal_imprinting1.00488231
76MP0006072_abnormal_retinal_apoptosis0.96675009
77MP0006035_abnormal_mitochondrial_morpho0.96142975
78MP0002019_abnormal_tumor_incidence0.95487467
79MP0002092_abnormal_eye_morphology0.95345784
80MP0009697_abnormal_copulation0.93931179
81MP0001984_abnormal_olfaction0.93129983
82MP0002332_abnormal_exercise_endurance0.93119886
83MP0003755_abnormal_palate_morphology0.92516949
84MP0002111_abnormal_tail_morphology0.90580369
85MP0002090_abnormal_vision0.90305720
86MP0009703_decreased_birth_body0.89932245
87MP0000516_abnormal_urinary_system0.89648645
88MP0005367_renal/urinary_system_phenotyp0.89648645
89MP0003315_abnormal_perineum_morphology0.89437242
90MP0001529_abnormal_vocalization0.88993382
91MP0005395_other_phenotype0.87271642
92MP0002796_impaired_skin_barrier0.87171332
93MP0000631_abnormal_neuroendocrine_gland0.87074325
94MP0002102_abnormal_ear_morphology0.86236047
95MP0000371_diluted_coat_color0.86178657
96MP0004142_abnormal_muscle_tone0.85504042
97MP0000432_abnormal_head_morphology0.84971119
98MP0000647_abnormal_sebaceous_gland0.83643012
99MP0002249_abnormal_larynx_morphology0.83003820
100MP0002269_muscular_atrophy0.82616930
101MP0003566_abnormal_cell_adhesion0.80757431
102MP0000653_abnormal_sex_gland0.80171486
103MP0003935_abnormal_craniofacial_develop0.79566221
104MP0001286_abnormal_eye_development0.79419449
105MP0003936_abnormal_reproductive_system0.79368611
106MP0000678_abnormal_parathyroid_gland0.79130810
107* MP0001929_abnormal_gametogenesis0.78941014
108MP0003172_abnormal_lysosome_physiology0.77951007
109MP0002127_abnormal_cardiovascular_syste0.77656860
110MP0008770_decreased_survivor_rate0.77060130
111MP0005501_abnormal_skin_physiology0.74845150
112MP0003453_abnormal_keratinocyte_physiol0.74735183
113MP0001177_atelectasis0.73956547
114MP0004233_abnormal_muscle_weight0.73282159
115MP0005023_abnormal_wound_healing0.73074004
116MP0000762_abnormal_tongue_morphology0.72072187
117MP0005394_taste/olfaction_phenotype0.71838012
118MP0005499_abnormal_olfactory_system0.71838012
119MP0000358_abnormal_cell_content/0.71581999
120MP0003861_abnormal_nervous_system0.70066508
121MP0003186_abnormal_redox_activity0.68321598
122MP0001545_abnormal_hematopoietic_system0.68257016
123MP0005397_hematopoietic_system_phenotyp0.68257016
124MP0005379_endocrine/exocrine_gland_phen0.67597979
125MP0005384_cellular_phenotype0.67278542
126MP0004185_abnormal_adipocyte_glucose0.66987990
127MP0002114_abnormal_axial_skeleton0.66514116
128MP0003937_abnormal_limbs/digits/tail_de0.65814101
129MP0002075_abnormal_coat/hair_pigmentati0.65796604
130MP0003938_abnormal_ear_development0.64790895
131MP0005621_abnormal_cell_physiology0.64348866
132MP0006276_abnormal_autonomic_nervous0.62312203
133MP0002081_perinatal_lethality0.60710764
134MP0004270_analgesia0.60456908
135MP0001346_abnormal_lacrimal_gland0.60400883
136MP0003137_abnormal_impulse_conducting0.58807600
137* MP0003698_abnormal_male_reproductive0.58415838
138MP0004147_increased_porphyrin_level0.58059594
139MP0003195_calcinosis0.56743761

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.61987697
2Rib fusion (HP:0000902)4.32983952
3Abnormality of the labia minora (HP:0012880)4.25289591
4Abnormality of the astrocytes (HP:0100707)4.14050553
5Astrocytoma (HP:0009592)4.14050553
6Breast hypoplasia (HP:0003187)3.91438782
7Rectovaginal fistula (HP:0000143)3.91185319
8Rectal fistula (HP:0100590)3.91185319
9Septo-optic dysplasia (HP:0100842)3.89146206
10Hypochromic microcytic anemia (HP:0004840)3.82497906
11Aplasia/hypoplasia of the humerus (HP:0006507)3.81470237
12Absent radius (HP:0003974)3.72147275
13Short humerus (HP:0005792)3.64093583
14Birth length less than 3rd percentile (HP:0003561)3.59427371
15Rhabdomyosarcoma (HP:0002859)3.58685506
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50794171
17Aplasia involving forearm bones (HP:0009822)3.48860055
18Absent forearm bone (HP:0003953)3.48860055
19Multiple enchondromatosis (HP:0005701)3.46848912
20Intestinal fistula (HP:0100819)3.38141294
21Supernumerary spleens (HP:0009799)3.37909151
22Neoplasm of the oral cavity (HP:0100649)3.37110475
23Glioma (HP:0009733)3.35734090
24Vaginal fistula (HP:0004320)3.34027969
25Chromsome breakage (HP:0040012)3.29640571
26Neoplasm of striated muscle (HP:0009728)3.28536984
27Medulloblastoma (HP:0002885)3.24842506
28Chronic bronchitis (HP:0004469)3.19355779
29Spastic diplegia (HP:0001264)3.18836039
30Impulsivity (HP:0100710)3.09839204
31Abnormality of the salivary glands (HP:0010286)3.09238775
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.09015608
33Patellar aplasia (HP:0006443)3.01267581
34Selective tooth agenesis (HP:0001592)2.99525053
35Shawl scrotum (HP:0000049)2.99295695
36Bilateral microphthalmos (HP:0007633)2.90702541
37Abnormality of the lower motor neuron (HP:0002366)2.88264975
38Carpal bone hypoplasia (HP:0001498)2.86667482
39Premature ovarian failure (HP:0008209)2.84279990
40Abnormality of pyrimidine metabolism (HP:0004353)2.81253467
41Choanal stenosis (HP:0000452)2.81123380
42Abnormality of the ileum (HP:0001549)2.78551879
43Hyperglycinemia (HP:0002154)2.77982822
44Tongue fasciculations (HP:0001308)2.75998685
45Aplasia/Hypoplasia of the patella (HP:0006498)2.74330143
46Neoplasm of the adrenal cortex (HP:0100641)2.70934338
47Malnutrition (HP:0004395)2.70348291
48Agnosia (HP:0010524)2.63340010
49Stenosis of the external auditory canal (HP:0000402)2.63239614
50Meckel diverticulum (HP:0002245)2.62537940
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58645841
52Cerebral hypomyelination (HP:0006808)2.57375908
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.56704083
54Abnormality of the septum pellucidum (HP:0007375)2.54900175
55Absent thumb (HP:0009777)2.52562752
56Abnormality of glycine metabolism (HP:0010895)2.51968848
57Abnormality of serine family amino acid metabolism (HP:0010894)2.51968848
58Fused cervical vertebrae (HP:0002949)2.51559488
59Muscle fibrillation (HP:0010546)2.50891354
60Abnormal lung lobation (HP:0002101)2.50588472
61Absent septum pellucidum (HP:0001331)2.50072165
62Trismus (HP:0000211)2.49438718
63Nephroblastoma (Wilms tumor) (HP:0002667)2.48027172
64Facial hemangioma (HP:0000329)2.46751446
65Abdominal situs inversus (HP:0003363)2.43411177
66Abnormality of abdominal situs (HP:0011620)2.43411177
67Maternal diabetes (HP:0009800)2.38571596
68Abnormality of homocysteine metabolism (HP:0010919)2.38472069
69Homocystinuria (HP:0002156)2.38472069
70Short hallux (HP:0010109)2.38156798
71Ectopic kidney (HP:0000086)2.31691444
72Aplasia/Hypoplasia of the hallux (HP:0008362)2.31333522
73Hypoglycemic seizures (HP:0002173)2.31150689
74Aqueductal stenosis (HP:0002410)2.29977021
75Adenoma sebaceum (HP:0009720)2.29914255
76Angiofibromas (HP:0010615)2.29914255
77Colon cancer (HP:0003003)2.26808830
78Optic nerve hypoplasia (HP:0000609)2.25474904
79Embryonal renal neoplasm (HP:0011794)2.25230879
80Protruding tongue (HP:0010808)2.24933934
81Pendular nystagmus (HP:0012043)2.24161138
82Abnormality of the preputium (HP:0100587)2.22371129
83Missing ribs (HP:0000921)2.22109045
84Spinal muscular atrophy (HP:0007269)2.22050557
85Concave nail (HP:0001598)2.20255174
86Degeneration of anterior horn cells (HP:0002398)2.19515999
87Abnormality of the anterior horn cell (HP:0006802)2.19515999
88Abnormality of serum amino acid levels (HP:0003112)2.18440808
89Cortical dysplasia (HP:0002539)2.15989712
90Basal cell carcinoma (HP:0002671)2.15959140
91Abnormal sex determination (HP:0012244)2.14732552
92Sex reversal (HP:0012245)2.14732552
93Abnormal number of incisors (HP:0011064)2.13050294
94Vertebral fusion (HP:0002948)2.12142114
95Abnormality of chromosome stability (HP:0003220)2.11593245
96Pancreatic islet-cell hyperplasia (HP:0004510)2.10116076
97Vertebral clefting (HP:0008428)2.07185305
98Facial cleft (HP:0002006)2.04870217
99Delayed puberty (HP:0000823)2.02954814
100Atrophy/Degeneration involving motor neurons (HP:0007373)2.02591460
101Duodenal stenosis (HP:0100867)1.99469785
102Small intestinal stenosis (HP:0012848)1.99469785
103Esophageal atresia (HP:0002032)1.98218821
104Hypoplastic female external genitalia (HP:0012815)1.97928631
105Rough bone trabeculation (HP:0100670)1.96707212
106Preaxial foot polydactyly (HP:0001841)1.96287803
107Embryonal neoplasm (HP:0002898)1.95872262
108Triphalangeal thumb (HP:0001199)1.94944753
109Cellular immunodeficiency (HP:0005374)1.93936442
110Hyperglycinuria (HP:0003108)1.93370130
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.91421684
112Hemivertebrae (HP:0002937)1.90893278
113Hyperinsulinemic hypoglycemia (HP:0000825)1.89216711
114Hepatoblastoma (HP:0002884)1.88907102
115Tracheoesophageal fistula (HP:0002575)1.87328910
116Metaphyseal cupping (HP:0003021)1.87228687
117Bifid tongue (HP:0010297)1.84997097
118Testicular atrophy (HP:0000029)1.84458682
119Oral leukoplakia (HP:0002745)1.83674407
120Atresia of the external auditory canal (HP:0000413)1.83572036
121Myelodysplasia (HP:0002863)1.83497410
122Volvulus (HP:0002580)1.83221358
123Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.82715021
124Hypoplasia of the pons (HP:0012110)1.82630330
125Abnormality of the clitoris (HP:0000056)1.81683773
126Labial hypoplasia (HP:0000066)1.81345432
127Intestinal atresia (HP:0011100)1.80634384
128Dandy-Walker malformation (HP:0001305)1.80451291
129Broad thumb (HP:0011304)1.80009220
130Abnormality of the duodenum (HP:0002246)1.79984226
131Breast aplasia (HP:0100783)1.79560150
132Orthostatic hypotension (HP:0001278)1.79387807
133Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78181455
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78120044
135Gastrointestinal atresia (HP:0002589)1.77742282
136Absent eyebrow (HP:0002223)1.77644739
137Horseshoe kidney (HP:0000085)1.77392663
138Neoplasm of the colon (HP:0100273)1.77099865
139Biliary tract neoplasm (HP:0100574)1.76287108
140Supernumerary ribs (HP:0005815)1.76190497
141Cafe-au-lait spot (HP:0000957)1.75809395
142Sloping forehead (HP:0000340)1.75080644
143Hypoplasia of the radius (HP:0002984)1.74723474
144Secondary amenorrhea (HP:0000869)1.74669978
145Gastrointestinal carcinoma (HP:0002672)1.74173043
146Malignant gastrointestinal tract tumors (HP:0006749)1.74173043
147Vertebral hypoplasia (HP:0008417)1.74147976
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74147976
149Abnormality of the middle phalanges of the toes (HP:0010183)1.72545245
150Progressive inability to walk (HP:0002505)1.71421505
151Neoplasm of the adrenal gland (HP:0100631)1.71068965
152Abnormal hair whorl (HP:0010721)1.69689932
153Clitoromegaly (HP:0000057)1.68731463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.40481767
2WEE13.75968986
3AKT33.41422793
4TTK3.10066468
5BUB13.06236076
6VRK22.99740348
7EPHA22.96458923
8ZAK2.90861974
9TAF12.73970137
10CDC72.61712944
11TNIK2.53459876
12NEK12.48587937
13CDK72.43696080
14PBK2.27866603
15PLK12.27120213
16ICK2.09119975
17NUAK12.02179961
18WNK32.01924987
19TYRO31.98118456
20NEK21.96123134
21CHEK21.85559154
22PLK41.79549313
23MATK1.79308639
24CDK191.75356038
25DDR21.74050132
26GRK51.68294405
27FGFR21.65483698
28RPS6KB21.65415849
29BRSK21.53457339
30LATS21.51095270
31SMG11.45552394
32MAP3K101.43640915
33SRPK11.33134413
34TSSK61.30648245
35TRIM281.29871305
36AURKA1.29057816
37CHEK11.27445616
38LATS11.27072552
39ATR1.26848887
40STK31.20880741
41MAP3K61.20844259
42PIM21.20540111
43ACVR1B1.20082495
44NME11.16074405
45ALK1.14515975
46AURKB1.14449241
47STK101.13729584
48GRK61.13696907
49CDK41.11903942
50TESK21.10882919
51DYRK31.10322177
52FRK1.09460534
53FGFR11.09345478
54PAK41.08436042
55NLK1.08258384
56PRKCI1.06721265
57PDK31.04609484
58PDK41.04609484
59ABL21.04014645
60PDK21.03914469
61CASK1.03572723
62CDK21.02453296
63CSNK1G11.02410006
64PIM11.02055691
65EIF2AK11.02011269
66PINK11.01979672
67BRD41.00326904
68PLK31.00142329
69OXSR10.99786209
70BMPR1B0.99609988
71ATM0.98879922
72BCKDK0.95798350
73DAPK10.95144860
74CDK60.93354482
75TIE10.89169127
76PNCK0.88312781
77MTOR0.86128859
78CAMK1D0.85917546
79ARAF0.83796145
80STK38L0.83113594
81CAMK1G0.82342976
82DYRK20.82146730
83INSRR0.80113041
84LMTK20.78547868
85STK240.77849848
86BRAF0.77343117
87CSNK1E0.77076630
88MAPKAPK30.75767882
89MAP3K80.74741893
90BRSK10.73699317
91CSNK1G20.72733100
92MAP3K110.72466226
93YES10.72438824
94BMX0.72396731
95ERBB40.71693938
96AKT20.70443764
97CSK0.69567114
98MAP3K40.69412378
99PASK0.68329486
100CSNK2A20.66974823
101MAPK150.65671494
102CDK10.64882294
103EIF2AK30.61929639
104MAP4K20.61832938
105PLK20.61761080
106PRKDC0.61653629
107BCR0.60118962
108PAK10.60113811
109MKNK20.59433300
110EEF2K0.59258400
111TLK10.59104537
112FGR0.58566093
113EIF2AK20.57911242
114CSNK1G30.57876366
115CSNK2A10.57642816
116MAPK70.57126039
117ERN10.56301236
118PRKG20.56214059
119DYRK1A0.54402181
120MELK0.54173574
121STK160.53928340
122KDR0.51032165
123NME20.49817705
124STK40.49293952
125GRK10.48298503
126PTK20.48106112
127MAP3K90.46700535
128EGFR0.46212819
129FLT30.46002276
130CDK30.45205229
131STK380.45174910
132CSNK1D0.43942000
133MET0.43612924
134MAPK100.42566970
135CSNK1A1L0.41460795
136MAPK140.41073385
137VRK10.39807386
138TAOK20.39511195
139CSNK1A10.39029385
140CSF1R0.38891472
141GSK3A0.38637930
142MKNK10.38389900
143UHMK10.37858670
144GSK3B0.36792979
145PRKCG0.36386837
146TEC0.36048186
147PRKCE0.35841344
148DYRK1B0.35793549
149MST40.35496223
150TGFBR10.35357654
151PDGFRA0.35062829
152RPS6KA40.28613816

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.82313723
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.65449631
3DNA replication_Homo sapiens_hsa030304.42249649
4RNA transport_Homo sapiens_hsa030133.56887154
5Base excision repair_Homo sapiens_hsa034103.01282916
6RNA polymerase_Homo sapiens_hsa030202.87171280
7Spliceosome_Homo sapiens_hsa030402.86617315
8Homologous recombination_Homo sapiens_hsa034402.69184637
9Nucleotide excision repair_Homo sapiens_hsa034202.62992257
10Cell cycle_Homo sapiens_hsa041102.47980493
11Fanconi anemia pathway_Homo sapiens_hsa034602.42762978
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41468331
13One carbon pool by folate_Homo sapiens_hsa006702.35860180
14Ribosome_Homo sapiens_hsa030102.33618820
15Vitamin B6 metabolism_Homo sapiens_hsa007502.22311848
16mRNA surveillance pathway_Homo sapiens_hsa030152.03622225
17Folate biosynthesis_Homo sapiens_hsa007901.93786771
18Proteasome_Homo sapiens_hsa030501.84642105
19Basal transcription factors_Homo sapiens_hsa030221.76022005
20p53 signaling pathway_Homo sapiens_hsa041151.73703250
21Pyrimidine metabolism_Homo sapiens_hsa002401.72676886
22RNA degradation_Homo sapiens_hsa030181.69839182
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60850626
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51045302
25Fructose and mannose metabolism_Homo sapiens_hsa000511.44348263
26Biosynthesis of amino acids_Homo sapiens_hsa012301.42854475
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40677669
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39258092
29mTOR signaling pathway_Homo sapiens_hsa041501.25306348
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22475765
31Non-homologous end-joining_Homo sapiens_hsa034501.21424331
32Propanoate metabolism_Homo sapiens_hsa006401.20979665
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15964949
34Selenocompound metabolism_Homo sapiens_hsa004501.08234881
35Fatty acid elongation_Homo sapiens_hsa000621.08175997
36Oocyte meiosis_Homo sapiens_hsa041141.08167448
37Protein export_Homo sapiens_hsa030601.06617956
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05237119
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.04093287
40Steroid biosynthesis_Homo sapiens_hsa001001.02846732
41Pyruvate metabolism_Homo sapiens_hsa006200.99387099
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98986548
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.93047331
44Hippo signaling pathway_Homo sapiens_hsa043900.92938149
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92416030
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90253497
47Vitamin digestion and absorption_Homo sapiens_hsa049770.88295536
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.88106617
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87037550
50Nicotine addiction_Homo sapiens_hsa050330.87002463
51Galactose metabolism_Homo sapiens_hsa000520.86487756
52Carbon metabolism_Homo sapiens_hsa012000.82460235
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82231827
54Phototransduction_Homo sapiens_hsa047440.81582755
55Parkinsons disease_Homo sapiens_hsa050120.81520973
56Purine metabolism_Homo sapiens_hsa002300.75365001
57Oxidative phosphorylation_Homo sapiens_hsa001900.75046159
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.74650001
59Basal cell carcinoma_Homo sapiens_hsa052170.72750497
60Arginine and proline metabolism_Homo sapiens_hsa003300.71019520
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70329944
62Hedgehog signaling pathway_Homo sapiens_hsa043400.69618593
63Epstein-Barr virus infection_Homo sapiens_hsa051690.68576231
64beta-Alanine metabolism_Homo sapiens_hsa004100.66289024
65TGF-beta signaling pathway_Homo sapiens_hsa043500.65835889
66MicroRNAs in cancer_Homo sapiens_hsa052060.65722907
67Linoleic acid metabolism_Homo sapiens_hsa005910.65537296
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65342741
69Fatty acid biosynthesis_Homo sapiens_hsa000610.64108693
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62408783
71Thyroid cancer_Homo sapiens_hsa052160.60115556
72Arachidonic acid metabolism_Homo sapiens_hsa005900.59584583
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59010075
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58561352
75Notch signaling pathway_Homo sapiens_hsa043300.55888553
76Taste transduction_Homo sapiens_hsa047420.54597679
77Glutathione metabolism_Homo sapiens_hsa004800.52796103
78Sulfur relay system_Homo sapiens_hsa041220.51795158
79Tryptophan metabolism_Homo sapiens_hsa003800.51367953
80Viral carcinogenesis_Homo sapiens_hsa052030.51098656
81Lysine degradation_Homo sapiens_hsa003100.50546771
82Adherens junction_Homo sapiens_hsa045200.50200741
83Retinol metabolism_Homo sapiens_hsa008300.49913169
84Ether lipid metabolism_Homo sapiens_hsa005650.48783343
85Pentose phosphate pathway_Homo sapiens_hsa000300.48423017
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48344980
87Tight junction_Homo sapiens_hsa045300.47449316
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46053433
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44975824
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44533233
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43313552
92Herpes simplex infection_Homo sapiens_hsa051680.43162658
93Bladder cancer_Homo sapiens_hsa052190.41067063
94Butanoate metabolism_Homo sapiens_hsa006500.40041004
95Fatty acid degradation_Homo sapiens_hsa000710.39257305
96Fatty acid metabolism_Homo sapiens_hsa012120.38759253
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38532129
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.37940610
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.37209735
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35841427
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34827195
102Regulation of autophagy_Homo sapiens_hsa041400.33842159
103HTLV-I infection_Homo sapiens_hsa051660.31297632
104Wnt signaling pathway_Homo sapiens_hsa043100.30788064
105Colorectal cancer_Homo sapiens_hsa052100.29720847
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29593375
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29342376
108Alzheimers disease_Homo sapiens_hsa050100.28913798
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28214714
110Melanoma_Homo sapiens_hsa052180.26690377
111Cardiac muscle contraction_Homo sapiens_hsa042600.26318033
112Pathways in cancer_Homo sapiens_hsa052000.26247024
113Shigellosis_Homo sapiens_hsa051310.26006032
114Caffeine metabolism_Homo sapiens_hsa002320.25860791
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25175615
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25108830
117Starch and sucrose metabolism_Homo sapiens_hsa005000.24611225
118Metabolic pathways_Homo sapiens_hsa011000.23953026
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23273015
120Huntingtons disease_Homo sapiens_hsa050160.23031428
121Fat digestion and absorption_Homo sapiens_hsa049750.22524336
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22417552
123Other glycan degradation_Homo sapiens_hsa005110.21855610
124Systemic lupus erythematosus_Homo sapiens_hsa053220.20781523
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19439376
126Small cell lung cancer_Homo sapiens_hsa052220.15859762
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15680370
128Legionellosis_Homo sapiens_hsa051340.14427962
129HIF-1 signaling pathway_Homo sapiens_hsa040660.13817970
130Arginine biosynthesis_Homo sapiens_hsa002200.13656441
131Choline metabolism in cancer_Homo sapiens_hsa052310.13582719
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12134099
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.10611406
134AMPK signaling pathway_Homo sapiens_hsa041520.09527612
135Acute myeloid leukemia_Homo sapiens_hsa052210.09142539
136Antigen processing and presentation_Homo sapiens_hsa046120.08597660

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