PRDM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.14675291
2cytidine metabolic process (GO:0046087)6.14675291
3cytidine catabolic process (GO:0006216)6.14675291
4pyrimidine ribonucleoside catabolic process (GO:0046133)5.52172783
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.51996412
6regulation of regulatory T cell differentiation (GO:0045589)4.89648064
7cellular response to interleukin-15 (GO:0071350)4.66927918
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.50899862
9response to interleukin-15 (GO:0070672)4.48151629
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.27989923
11DNA deamination (GO:0045006)4.17488807
12regulation of interleukin-12 biosynthetic process (GO:0045075)3.97545802
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97234739
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.97234739
15modulation by symbiont of host immune response (GO:0052553)3.97234739
16positive regulation by symbiont of host defense response (GO:0052509)3.97234739
17modulation by symbiont of host defense response (GO:0052031)3.97234739
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97234739
19positive T cell selection (GO:0043368)3.84348138
20positive regulation of interleukin-8 secretion (GO:2000484)3.80167884
21regulation of T cell tolerance induction (GO:0002664)3.75271477
22branching involved in labyrinthine layer morphogenesis (GO:0060670)3.68689479
23regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.64675961
24substrate-dependent cell migration (GO:0006929)3.58323547
25negative regulation of viral genome replication (GO:0045071)3.52002504
26regulation of interferon-beta biosynthetic process (GO:0045357)3.49136976
27positive regulation of defense response to virus by host (GO:0002230)3.48294429
28macrophage activation involved in immune response (GO:0002281)3.44366833
29positive regulation of gamma-delta T cell activation (GO:0046645)3.43396097
30negative regulation of interleukin-12 production (GO:0032695)3.40439880
31regulation of T cell receptor signaling pathway (GO:0050856)3.40211456
32regulation of interleukin-2 biosynthetic process (GO:0045076)3.38599382
33antigen processing and presentation of endogenous antigen (GO:0019883)3.38136444
34T-helper 1 type immune response (GO:0042088)3.35756707
35T cell selection (GO:0045058)3.34598863
36type I interferon signaling pathway (GO:0060337)3.34271458
37cellular response to type I interferon (GO:0071357)3.34271458
38neutrophil activation involved in immune response (GO:0002283)3.32987505
39regulation of natural killer cell mediated immunity (GO:0002715)3.32678064
40regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.32678064
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32059831
42response to type I interferon (GO:0034340)3.30854195
43detection of other organism (GO:0098543)3.29733980
44dendritic cell chemotaxis (GO:0002407)3.29175695
45negative regulation of T cell mediated immunity (GO:0002710)3.28297942
46T cell costimulation (GO:0031295)3.27838945
47regulation of interferon-alpha production (GO:0032647)3.25342112
48detection of bacterium (GO:0016045)3.24890972
49positive regulation of lymphocyte migration (GO:2000403)3.24433850
50lymphocyte costimulation (GO:0031294)3.23030890
51* negative regulation of B cell proliferation (GO:0030889)3.20745697
52immunoglobulin mediated immune response (GO:0016064)3.19042059
53positive regulation of interleukin-1 beta secretion (GO:0050718)3.18802892
54NIK/NF-kappaB signaling (GO:0038061)3.18547458
55positive regulation of natural killer cell mediated immunity (GO:0002717)3.17142127
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.16754932
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16584996
58regulation of interleukin-1 beta secretion (GO:0050706)3.15323912
59T cell receptor signaling pathway (GO:0050852)3.15285054
60regulation of lymphocyte chemotaxis (GO:1901623)3.14033601
61leukocyte aggregation (GO:0070486)3.13746028
62antigen receptor-mediated signaling pathway (GO:0050851)3.11524477
63response to muramyl dipeptide (GO:0032495)3.10371937
64regulation of leukocyte mediated cytotoxicity (GO:0001910)3.10186392
65regulation of B cell receptor signaling pathway (GO:0050855)3.09618555
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08870665
67negative regulation of cell killing (GO:0031342)3.08870665
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.07592752
69dendritic cell migration (GO:0036336)3.07042273
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06759535
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06759535
72regulation of interleukin-8 secretion (GO:2000482)3.06320972
73Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05938472
74regulation of T cell mediated cytotoxicity (GO:0001914)3.05097578
75lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03567130
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03262775
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.02365794
78positive regulation of chemokine biosynthetic process (GO:0045080)3.00912005
79positive thymic T cell selection (GO:0045059)3.00888531
80regulation of lymphocyte migration (GO:2000401)3.00545788
81regulation of chronic inflammatory response (GO:0002676)2.99259081
82positive regulation of interleukin-1 secretion (GO:0050716)2.98844334
83chemokine-mediated signaling pathway (GO:0070098)2.98780215
84regulation of cell killing (GO:0031341)2.98388944
85regulation of T-helper 1 cell differentiation (GO:0045625)2.98185392
86positive regulation of T cell chemotaxis (GO:0010820)2.96593520
87regulation of T cell chemotaxis (GO:0010819)2.96593520
88activated T cell proliferation (GO:0050798)2.95967153
89interferon-gamma production (GO:0032609)2.95010035
90positive regulation of T cell migration (GO:2000406)2.94721265
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.93672362
92regulation of tolerance induction (GO:0002643)2.92483939
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90975280
94response to interferon-beta (GO:0035456)2.90613671
95positive regulation of cellular amide metabolic process (GO:0034250)2.89178956
96neutrophil activation (GO:0042119)2.86031680
97positive regulation of cell killing (GO:0031343)2.85982393
98negative regulation of cytokine production involved in immune response (GO:0002719)2.83633178
99granulocyte activation (GO:0036230)2.83312462
100positive regulation of cholesterol efflux (GO:0010875)2.83109658
101lymphocyte chemotaxis (GO:0048247)2.82924619
102* regulation of B cell proliferation (GO:0030888)2.82785458
103regulation of T cell migration (GO:2000404)2.82153467
104response to peptidoglycan (GO:0032494)2.80723626
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80520978
106endothelial tube morphogenesis (GO:0061154)2.80386573
107morphogenesis of an endothelium (GO:0003159)2.80386573
108* negative regulation of B cell activation (GO:0050869)2.79785029
109regulation of interleukin-1 secretion (GO:0050704)2.79715432
110macrophage activation (GO:0042116)2.78364778
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77764682
112positive regulation of interferon-alpha production (GO:0032727)2.76855738
113regulation of isotype switching to IgG isotypes (GO:0048302)2.76650845
114lymphocyte migration (GO:0072676)2.75864820
115positive regulation of macrophage cytokine production (GO:0060907)2.72054644
116I-kappaB phosphorylation (GO:0007252)2.71410890
117myeloid dendritic cell differentiation (GO:0043011)2.71096135
118regulation of MHC class II biosynthetic process (GO:0045346)2.70375348
119positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.67994100
120B cell receptor signaling pathway (GO:0050853)2.65939879
121tolerance induction (GO:0002507)2.65354053
122CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.62543860
123T-helper cell differentiation (GO:0042093)2.62543860
124cytokine secretion (GO:0050663)2.60562229
125negative thymic T cell selection (GO:0045060)2.59080761
126negative regulation of osteoclast differentiation (GO:0045671)2.58786564
127regulation of gamma-delta T cell activation (GO:0046643)2.56853712
128microglial cell activation (GO:0001774)2.52835306
129myeloid dendritic cell activation (GO:0001773)2.52828525
130Notch signaling involved in heart development (GO:0061314)2.52275346
131establishment of endothelial barrier (GO:0061028)2.51557233
132regulation of fibroblast apoptotic process (GO:2000269)2.51229760
133thymic T cell selection (GO:0045061)2.51167690
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.50069304
135negative T cell selection (GO:0043383)2.49493104
136T cell migration (GO:0072678)2.49101239
137regulation of gamma-delta T cell differentiation (GO:0045586)2.46597672
138interferon-gamma-mediated signaling pathway (GO:0060333)2.46005312
139positive regulation of cytokine biosynthetic process (GO:0042108)2.45734020
140leukocyte cell-cell adhesion (GO:0007159)2.45698927
141B cell proliferation (GO:0042100)2.45147820
142positive regulation of leukocyte apoptotic process (GO:2000108)2.44494025
143regulation of alpha-beta T cell proliferation (GO:0046640)2.43587760
144germinal center formation (GO:0002467)2.43368389
145detection of molecule of bacterial origin (GO:0032490)2.42902003
146B cell mediated immunity (GO:0019724)2.42058900
147negative regulation of NF-kappaB import into nucleus (GO:0042347)2.41167445
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.40244797
149regulation of interleukin-12 production (GO:0032655)2.40184830
150positive regulation of tolerance induction (GO:0002645)2.38925390
151regulation of integrin activation (GO:0033623)2.38781333
152positive regulation of interleukin-2 production (GO:0032743)2.38777322
153regulation of cytokine secretion involved in immune response (GO:0002739)2.36212403
154cytoplasmic mRNA processing body assembly (GO:0033962)2.35997056
155cellular extravasation (GO:0045123)2.35719314
156natural killer cell mediated immunity (GO:0002228)2.35305575
157natural killer cell mediated cytotoxicity (GO:0042267)2.35305575
158myeloid cell activation involved in immune response (GO:0002275)2.34266293
159alpha-beta T cell differentiation involved in immune response (GO:0002293)2.33817730
160alpha-beta T cell activation involved in immune response (GO:0002287)2.33817730
161T cell differentiation involved in immune response (GO:0002292)2.33817730
162* regulation of B cell differentiation (GO:0045577)2.33665927
163positive regulation of B cell proliferation (GO:0030890)2.32959082
164positive regulation of interferon-beta production (GO:0032728)2.32663922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.17245222
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.46198316
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.37057177
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.35138135
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.24067606
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.22237095
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.90193296
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.89564322
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.27472327
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.16532187
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10057031
12RUNX_20019798_ChIP-Seq_JUKART_Human2.76163210
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67709233
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62054527
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61760317
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.50552802
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.48086705
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47677965
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43880174
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28752333
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19211915
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15557055
23E2F7_22180533_ChIP-Seq_HELA_Human2.06878075
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02901211
25* MYB_26560356_Chip-Seq_TH2_Human1.95660465
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93914551
27* MAF_26560356_Chip-Seq_TH1_Human1.92475296
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90767399
29* MYB_26560356_Chip-Seq_TH1_Human1.81395898
30GATA1_22025678_ChIP-Seq_K562_Human1.80118868
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79835203
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79502610
33TCF7_22412390_ChIP-Seq_EML_Mouse1.77769907
34MYC_22102868_ChIP-Seq_BL_Human1.75848088
35* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74775015
36* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74775015
37* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74775015
38* SMAD_19615063_ChIP-ChIP_OVARY_Human1.65088378
39* VDR_24763502_ChIP-Seq_THP-1_Human1.60050072
40VDR_21846776_ChIP-Seq_THP-1_Human1.56225760
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52334396
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.51720127
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49184285
44* SPI1_23547873_ChIP-Seq_NB4_Human1.48836226
45* PU_27001747_Chip-Seq_BMDM_Mouse1.46816429
46* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45686365
47* UTX_26944678_Chip-Seq_JUKART_Human1.40892978
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39308963
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.37881059
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36834667
51* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36129833
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.35410364
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35122439
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34592938
55* VDR_24787735_ChIP-Seq_THP-1_Human1.32444321
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.32313411
57SCL_19346495_ChIP-Seq_HPC-7_Human1.31708626
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31595976
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31182460
60SPI1_23127762_ChIP-Seq_K562_Human1.29547987
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.29445492
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27757872
63KDM2B_26808549_Chip-Seq_DND41_Human1.26558100
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24601554
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24601554
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.23518353
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22989326
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22062274
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21141797
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.19881865
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.19701219
72* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19698138
73GATA3_27048872_Chip-Seq_THYMUS_Human1.19004469
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11793324
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10391334
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09915949
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.09859505
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07152507
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.04865956
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04704953
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04124722
82* SMRT_27268052_Chip-Seq_Bcells_Human1.03858847
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00889226
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99517630
85* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97221617
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96550065
87SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95948748
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95261699
89* EZH2_27294783_Chip-Seq_NPCs_Mouse0.95150688
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95032472
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.94223105
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92872738
93* GATA3_26560356_Chip-Seq_TH1_Human0.92767578
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91448286
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91043680
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90289468
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90200335
98MAF_26560356_Chip-Seq_TH2_Human0.89601475
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89095398
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89061135
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88704161
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87163075
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86876986
104* GATA3_26560356_Chip-Seq_TH2_Human0.86726658
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.84665738
106* KDM2B_26808549_Chip-Seq_JURKAT_Human0.83644762
107CJUN_26792858_Chip-Seq_BT549_Human0.83025126
108* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82993111
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82735668
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82713991
111CLOCK_20551151_ChIP-Seq_293T_Human0.82699588
112* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82061601
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80883424
114RXR_22108803_ChIP-Seq_LS180_Human0.80760423
115* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80620832
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.80349370
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80108885
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79943158
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79679123
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78613343
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78596894
122* TP63_23658742_ChIP-Seq_EP156T_Human0.77638886
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77372888
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76783307
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76629221
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.76080323
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75802722
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72763733
129VDR_22108803_ChIP-Seq_LS180_Human0.71141965
130* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.71108865
131* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70990815
132* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70799702
133* CRX_20693478_ChIP-Seq_RETINA_Mouse0.69725052
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69077880
135* GATA2_19941826_ChIP-Seq_K562_Human0.68394593
136GATA1_19941826_ChIP-Seq_K562_Human0.67573841
137EGR1_19032775_ChIP-ChIP_M12_Human0.67382604
138* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.66437118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.73712889
2MP0003303_peritoneal_inflammation3.35948314
3MP0005671_abnormal_response_to2.61098344
4MP0001790_abnormal_immune_system2.52534539
5MP0005387_immune_system_phenotype2.52534539
6MP0004947_skin_inflammation2.52382477
7MP0003724_increased_susceptibility_to2.48769977
8MP0001800_abnormal_humoral_immune2.47471035
9MP0003436_decreased_susceptibility_to2.44298306
10MP0005000_abnormal_immune_tolerance2.43375851
11MP0003300_gastrointestinal_ulcer2.31084609
12MP0009785_altered_susceptibility_to2.26694408
13MP0002452_abnormal_antigen_presenting2.26169360
14MP0004510_myositis2.17566361
15MP0002148_abnormal_hypersensitivity_rea2.17355148
16MP0006082_CNS_inflammation2.14165388
17MP0002723_abnormal_immune_serum2.09900299
18MP0005076_abnormal_cell_differentiation2.05978444
19MP0002419_abnormal_innate_immunity2.03537574
20* MP0005025_abnormal_response_to1.98746202
21MP0002254_reproductive_system_inflammat1.97657020
22MP0003448_altered_tumor_morphology1.96283281
23MP0002006_tumorigenesis1.93028021
24MP0002405_respiratory_system_inflammati1.92411630
25MP0001819_abnormal_immune_cell1.89970382
26MP0002420_abnormal_adaptive_immunity1.88977457
27MP0001873_stomach_inflammation1.87744674
28MP0000685_abnormal_immune_system1.87608809
29MP0002166_altered_tumor_susceptibility1.83729094
30MP0003453_abnormal_keratinocyte_physiol1.83111016
31MP0001853_heart_inflammation1.81858036
32MP0010234_abnormal_vibrissa_follicle1.78338487
33MP0002796_impaired_skin_barrier1.71792821
34MP0010352_gastrointestinal_tract_polyps1.68401417
35MP0003705_abnormal_hypodermis_morpholog1.66963390
36MP0002009_preneoplasia1.63935051
37MP0001879_abnormal_lymphatic_vessel1.60263029
38MP0000569_abnormal_digit_pigmentation1.59205512
39MP0003763_abnormal_thymus_physiology1.59011585
40MP0010155_abnormal_intestine_physiology1.54079745
41MP0010307_abnormal_tumor_latency1.52674123
42MP0009278_abnormal_bone_marrow1.49118705
43MP0005310_abnormal_salivary_gland1.48465536
44MP0003866_abnormal_defecation1.46539648
45MP0002398_abnormal_bone_marrow1.46512025
46MP0003191_abnormal_cellular_cholesterol1.44837076
47MP0000716_abnormal_immune_system1.43068265
48MP0000465_gastrointestinal_hemorrhage1.42346093
49MP0001533_abnormal_skeleton_physiology1.40001564
50MP0003828_pulmonary_edema1.37532962
51MP0005167_abnormal_blood-brain_barrier1.37520744
52MP0006054_spinal_hemorrhage1.36722201
53MP0001845_abnormal_inflammatory_respons1.33005278
54MP0002998_abnormal_bone_remodeling1.30333398
55MP0003566_abnormal_cell_adhesion1.30260695
56MP0005275_abnormal_skin_tensile1.25315266
57MP0001216_abnormal_epidermal_layer1.24500255
58MP0003045_fibrosis1.22279354
59MP0000858_altered_metastatic_potential1.21966438
60MP0000343_altered_response_to1.21049676
61MP0002098_abnormal_vibrissa_morphology1.19466344
62MP0001851_eye_inflammation1.19277586
63MP0000689_abnormal_spleen_morphology1.18287753
64MP0002722_abnormal_immune_system1.15255684
65MP0010368_abnormal_lymphatic_system1.14679823
66MP0000647_abnormal_sebaceous_gland1.14518079
67MP0001243_abnormal_dermal_layer1.14221464
68MP0008057_abnormal_DNA_replication1.11676766
69MP0002429_abnormal_blood_cell1.11435052
70MP0005464_abnormal_platelet_physiology1.09702925
71MP0008004_abnormal_stomach_pH1.09467298
72MP0009764_decreased_sensitivity_to1.08615001
73* MP0009333_abnormal_splenocyte_physiolog1.06253032
74MP0000490_abnormal_crypts_of1.04933147
75MP0005397_hematopoietic_system_phenotyp1.02848393
76MP0001545_abnormal_hematopoietic_system1.02848393
77MP0005501_abnormal_skin_physiology1.02681390
78MP0009765_abnormal_xenobiotic_induced1.02014161
79MP0000767_abnormal_smooth_muscle1.01451872
80MP0001191_abnormal_skin_condition1.00068648
81MP0003075_altered_response_to0.98129932
82MP0002163_abnormal_gland_morphology0.97631037
83MP0000703_abnormal_thymus_morphology0.96122461
84MP0005166_decreased_susceptibility_to0.94238335
85MP0009763_increased_sensitivity_to0.93826999
86MP0005023_abnormal_wound_healing0.92353648
87MP0010678_abnormal_skin_adnexa0.91252430
88MP0004808_abnormal_hematopoietic_stem0.89336722
89MP0000371_diluted_coat_color0.88446660
90MP0002933_joint_inflammation0.87953096
91MP0002277_abnormal_respiratory_mucosa0.87840699
92MP0004264_abnormal_extraembryonic_tissu0.87231624
93MP0004381_abnormal_hair_follicle0.85284639
94MP0004272_abnormal_basement_membrane0.84113113
95MP0000377_abnormal_hair_follicle0.83327076
96MP0005390_skeleton_phenotype0.83292144
97MP0005174_abnormal_tail_pigmentation0.83191382
98MP0008469_abnormal_protein_level0.81304483
99MP0002060_abnormal_skin_morphology0.80824736
100MP0000383_abnormal_hair_follicle0.79382384
101MP0001663_abnormal_digestive_system0.77084729
102MP0000627_abnormal_mammary_gland0.75635224
103MP0002138_abnormal_hepatobiliary_system0.75099645
104MP0005248_abnormal_Harderian_gland0.73876307
105MP0005058_abnormal_lysosome_morphology0.73820790
106MP0000249_abnormal_blood_vessel0.73696440
107MP0003172_abnormal_lysosome_physiology0.73404569
108MP0001915_intracranial_hemorrhage0.73223969
109MP0009931_abnormal_skin_appearance0.73050242
110MP0001542_abnormal_bone_strength0.72880389
111MP0002396_abnormal_hematopoietic_system0.70801871
112MP0009840_abnormal_foam_cell0.70414445
113MP0005075_abnormal_melanosome_morpholog0.69052198
114MP0002136_abnormal_kidney_physiology0.66034385
115MP0004883_abnormal_blood_vessel0.65573248
116MP0000015_abnormal_ear_pigmentation0.64399034
117MP0005164_abnormal_response_to0.64309059
118MP0003795_abnormal_bone_structure0.63224150
119MP0000604_amyloidosis0.60541405
120MP0003279_aneurysm0.58984845
121MP0002019_abnormal_tumor_incidence0.57152602
122MP0003183_abnormal_peptide_metabolism0.56644646
123MP0002876_abnormal_thyroid_physiology0.54390340
124MP0001348_abnormal_lacrimal_gland0.49992749
125MP0002332_abnormal_exercise_endurance0.49644815
126MP0000367_abnormal_coat/_hair0.47965002
127MP0008873_increased_physiological_sensi0.47149341

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.01377963
2Eczematoid dermatitis (HP:0000976)5.37663427
3Retrobulbar optic neuritis (HP:0100654)5.02748678
4Optic neuritis (HP:0100653)5.02748678
5T lymphocytopenia (HP:0005403)4.97492126
6Orchitis (HP:0100796)4.83890007
7Myositis (HP:0100614)4.47189160
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.38831843
9Recurrent abscess formation (HP:0002722)4.26575570
10IgG deficiency (HP:0004315)3.85650744
11Abnormality of T cells (HP:0002843)3.85191637
12Mediastinal lymphadenopathy (HP:0100721)3.67153052
13Recurrent bacterial skin infections (HP:0005406)3.63225663
14Chronic diarrhea (HP:0002028)3.52386638
15Increased IgM level (HP:0003496)3.45049397
16Pulmonary infiltrates (HP:0002113)3.32057853
17Increased IgE level (HP:0003212)3.17104972
18Abnormality of T cell physiology (HP:0011840)3.16756352
19Arterial thrombosis (HP:0004420)3.15132738
20Keratoconjunctivitis sicca (HP:0001097)3.10301138
21Abnormality of eosinophils (HP:0001879)3.09105566
22Gangrene (HP:0100758)3.01675154
23Vasculitis (HP:0002633)2.93338518
24Recurrent cutaneous fungal infections (HP:0011370)2.90898545
25Chronic mucocutaneous candidiasis (HP:0002728)2.90898545
26Severe combined immunodeficiency (HP:0004430)2.90858949
27Hematochezia (HP:0002573)2.88255155
28Colitis (HP:0002583)2.86712767
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.85464915
30Eosinophilia (HP:0001880)2.83371774
31Hypoproteinemia (HP:0003075)2.82883338
32Abnormality of the nasal septum (HP:0000419)2.82031676
33Recurrent viral infections (HP:0004429)2.81374812
34Pulmonary fibrosis (HP:0002206)2.79895832
35Keratoconjunctivitis (HP:0001096)2.78788270
36Abnormality of macrophages (HP:0004311)2.78370453
37Lymphopenia (HP:0001888)2.74932151
38Hemoptysis (HP:0002105)2.74724263
39Recurrent fungal infections (HP:0002841)2.73994868
40Autoimmune thrombocytopenia (HP:0001973)2.73114444
41Meningitis (HP:0001287)2.72146908
42Thyroiditis (HP:0100646)2.71955670
43Myocardial infarction (HP:0001658)2.69885413
44Recurrent gram-negative bacterial infections (HP:0005420)2.69668734
45Elevated erythrocyte sedimentation rate (HP:0003565)2.60712447
46Chronic obstructive pulmonary disease (HP:0006510)2.60116024
47Obstructive lung disease (HP:0006536)2.60116024
48Oral leukoplakia (HP:0002745)2.59756400
49Cellulitis (HP:0100658)2.55273814
50Thick nail (HP:0001805)2.51294641
51Skin rash (HP:0000988)2.50422698
52Joint swelling (HP:0001386)2.50346356
53Hypotrichosis (HP:0001006)2.50267566
54Esophageal varix (HP:0002040)2.46497118
55Stomatitis (HP:0010280)2.44669426
56Gingivitis (HP:0000230)2.43950601
57Interstitial pulmonary disease (HP:0006530)2.41595186
58Pustule (HP:0200039)2.41379013
59Inflammation of the large intestine (HP:0002037)2.39008084
60Abnormality of the fingertips (HP:0001211)2.38440166
61Parakeratosis (HP:0001036)2.38105061
62Granulocytopenia (HP:0001913)2.37758885
63Chorioretinal atrophy (HP:0000533)2.34281351
64Erythroderma (HP:0001019)2.34093553
65Abnormality of the pleura (HP:0002103)2.34091605
66Combined immunodeficiency (HP:0005387)2.33149998
67Prostate neoplasm (HP:0100787)2.30439272
68Midline defect of the nose (HP:0004122)2.29415627
69Agammaglobulinemia (HP:0004432)2.28348467
70Spontaneous hematomas (HP:0007420)2.27961665
71IgA deficiency (HP:0002720)2.27956038
72Gastrointestinal infarctions (HP:0005244)2.25409800
73Chronic otitis media (HP:0000389)2.24235462
74Verrucae (HP:0200043)2.23030265
75Papilloma (HP:0012740)2.23030265
76Stomach cancer (HP:0012126)2.22753969
77Amaurosis fugax (HP:0100576)2.22420205
78Polyneuropathy (HP:0001271)2.22405441
79Periodontitis (HP:0000704)2.22268948
80Abnormality of the prostate (HP:0008775)2.19958936
81Recurrent bronchitis (HP:0002837)2.18955185
82Panhypogammaglobulinemia (HP:0003139)2.18809113
83Abnormality of male internal genitalia (HP:0000022)2.18136250
84Chest pain (HP:0100749)2.17996589
85Gastrointestinal inflammation (HP:0004386)2.17083343
86Recurrent skin infections (HP:0001581)2.15835023
87Glomerulopathy (HP:0100820)2.15420645
88Pigmentary retinal degeneration (HP:0001146)2.14869867
89Aplasia cutis congenita (HP:0001057)2.12899268
90Adactyly (HP:0009776)2.12668670
91Short 4th metacarpal (HP:0010044)2.12629800
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12629800
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10157212
94Porencephaly (HP:0002132)2.09677983
95Congenital ichthyosiform erythroderma (HP:0007431)2.09538339
96Epistaxis (HP:0000421)2.07986773
97Abnormality of the pericardium (HP:0001697)2.07088107
98Lymphoma (HP:0002665)2.06771070
99B lymphocytopenia (HP:0010976)2.06667819
100Abnormality of B cell number (HP:0010975)2.06667819
101Absent hand (HP:0004050)2.06544610
102Premature loss of primary teeth (HP:0006323)2.06251210
103Pendular nystagmus (HP:0012043)2.06207671
104Short middle phalanx of the 5th finger (HP:0004220)2.05253649
105Osteomyelitis (HP:0002754)2.04920202
106Anorexia (HP:0002039)2.04317725
107Recurrent sinusitis (HP:0011108)2.03879009
108Spondylolisthesis (HP:0003302)2.02955787
109Trigonocephaly (HP:0000243)2.02433055
110Portal hypertension (HP:0001409)2.01455572
111Aplastic anemia (HP:0001915)2.01255962
112Depressed nasal tip (HP:0000437)1.99274421
113Milia (HP:0001056)1.98068470
114Ureteral obstruction (HP:0006000)1.97819990
115Ectropion (HP:0000656)1.97724914
116Osteolytic defects of the hand bones (HP:0009699)1.96812400
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.96812400
118Erythema (HP:0010783)1.96509166
119Emphysema (HP:0002097)1.94859148
120Alveolar cell carcinoma (HP:0006519)1.94763258
121Pulmonary embolism (HP:0002204)1.94439457
122Fatigue (HP:0012378)1.93739000
123Blepharitis (HP:0000498)1.92659480
124Abnormality of the parietal bone (HP:0002696)1.91913903
125Abnormality of the hepatic vasculature (HP:0006707)1.90654023
126Abnormality of the axillary hair (HP:0100134)1.89406129
127Hypergammaglobulinemia (HP:0010702)1.87271930
128Ureteral stenosis (HP:0000071)1.87084973
129Urticaria (HP:0001025)1.84747326
130Sepsis (HP:0100806)1.84037674
131Abnormality of the nasal mucosa (HP:0000433)1.83965678
132Posterior subcapsular cataract (HP:0007787)1.82877381
133Vacuolated lymphocytes (HP:0001922)1.81791931
134Skull defect (HP:0001362)1.81736797
135Polycythemia (HP:0001901)1.81722728
136Abnormality of nail color (HP:0100643)1.80657621
137IgM deficiency (HP:0002850)1.80377752
138Leukocytosis (HP:0001974)1.80127099
139Skin ulcer (HP:0200042)1.79098341
140Restrictive lung disease (HP:0002091)1.77310720
141Intestinal fistula (HP:0100819)1.77164232
142Abnormality of T cell number (HP:0011839)1.73200995
143Encephalitis (HP:0002383)1.69451946
144Thrombophlebitis (HP:0004418)1.69417978
145Gastrointestinal stroma tumor (HP:0100723)1.69329753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.44754420
2MAP3K143.58460109
3MAP3K103.25708396
4MAP4K13.01856924
5PDK22.63139568
6TYK22.40856979
7CDK122.38584897
8TGFBR22.33027640
9TBK12.25244332
10ERN12.23816681
11JAK32.20154068
12IKBKE2.18319226
13RIPK12.17185412
14RIPK42.13875469
15IKBKB2.11287938
16BMPR1B2.05446182
17JAK11.99698566
18INSRR1.93291324
19IRAK41.91295291
20STK101.89983181
21CHUK1.80797618
22SIK31.77507596
23BLK1.71814844
24ZAP701.65103157
25IRAK31.61891427
26CSK1.56348544
27FGFR31.55659511
28KDR1.51078392
29GRK71.45307355
30ACVR1B1.43641436
31ITK1.41399906
32BMPR21.38647315
33EIF2AK31.34559530
34SIK21.34390106
35CDK61.33130662
36CDK91.27295373
37RPS6KA41.26017328
38PIM11.24412663
39LCK1.20628163
40PIK3CG1.19945697
41FGFR41.19390748
42LATS11.19164216
43DMPK1.18841944
44STK241.17945021
45EPHB11.17872298
46HCK1.16470045
47NEK21.12670145
48MARK31.11430807
49CSF1R1.09545497
50FRK1.07790174
51STK31.07026496
52KIT1.05450062
53CAMKK21.05268975
54SYK1.02768215
55TEC1.01470327
56JAK21.01293652
57TAOK31.01020994
58MAP3K130.99062696
59MST40.95170995
60BTK0.94355104
61EPHA30.92092599
62TYRO30.89963652
63BMX0.87833508
64NEK90.86416519
65PDGFRB0.86329788
66PRPF4B0.86056619
67NLK0.82593070
68YES10.79604488
69IRAK20.77370533
70AKT30.76082219
71ADRBK20.74602549
72PTK60.74430297
73CAMK1D0.74044924
74BRD40.73846865
75EPHB20.72629557
76LRRK20.71967195
77LYN0.69838965
78ABL10.69635419
79EGFR0.66683999
80TRPM70.66306311
81TRIM280.65960651
82MAP3K10.64499386
83GSK3A0.61661160
84MAPK70.61544618
85MELK0.60645764
86NUAK10.59453765
87TGFBR10.59128753
88IRAK10.57303189
89FGR0.56349715
90MAP3K30.55720990
91NEK60.55404456
92MAP3K120.54753566
93FGFR10.53950270
94HIPK20.52585250
95PDK10.50317752
96PRKCQ0.49945167
97CDK40.49850003
98INSR0.49442669
99TNK20.48944992
100STK40.48377138
101MAP2K30.47720582
102MATK0.47047861
103GRK60.46602637
104MAPKAPK20.46062922
105CAMK1G0.45528210
106MAP3K90.43768736
107FGFR20.43564755
108TIE10.42896577
109CLK10.42584309
110ERBB30.41598946
111MOS0.39311700
112MAPKAPK30.38969135
113MAPK110.38829621
114SGK30.38662982
115IGF1R0.38609950
116GRK10.37539102
117PRKD10.36598236
118MAP2K60.35873510
119SIK10.34673747
120PRKCD0.33994790
121MAPK10.33430835
122FER0.32679084
123PRKCH0.32519130
124TAOK10.32499363
125FES0.32491683
126ALK0.32418583
127MTOR0.32386987
128SGK20.32261562
129ERBB40.30119915
130PIK3CA0.29596800
131GRK50.29275125
132FYN0.29273043
133MAPK30.27807401
134TAF10.27232509
135MAPK120.27122752
136MAP3K80.26250863
137MAP3K50.23796096

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.88404299
2Allograft rejection_Homo sapiens_hsa053302.62317829
3Graft-versus-host disease_Homo sapiens_hsa053322.49117405
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.47695238
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42350788
6Osteoclast differentiation_Homo sapiens_hsa043802.36608592
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.35506151
8Staphylococcus aureus infection_Homo sapiens_hsa051502.11501420
9B cell receptor signaling pathway_Homo sapiens_hsa046621.97588849
10Asthma_Homo sapiens_hsa053101.95328165
11Autoimmune thyroid disease_Homo sapiens_hsa053201.94867503
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92718261
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91087436
14Malaria_Homo sapiens_hsa051441.87560799
15Measles_Homo sapiens_hsa051621.86158003
16Primary immunodeficiency_Homo sapiens_hsa053401.83310462
17Legionellosis_Homo sapiens_hsa051341.81495392
18Toxoplasmosis_Homo sapiens_hsa051451.80006323
19T cell receptor signaling pathway_Homo sapiens_hsa046601.72250057
20Tuberculosis_Homo sapiens_hsa051521.65772810
21Pertussis_Homo sapiens_hsa051331.65455220
22Antigen processing and presentation_Homo sapiens_hsa046121.59427770
23Hematopoietic cell lineage_Homo sapiens_hsa046401.58402755
24TNF signaling pathway_Homo sapiens_hsa046681.57237858
25African trypanosomiasis_Homo sapiens_hsa051431.51803256
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51679858
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.45510712
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41019014
29Influenza A_Homo sapiens_hsa051641.36731711
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36319584
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36190713
32Apoptosis_Homo sapiens_hsa042101.34097370
33Rheumatoid arthritis_Homo sapiens_hsa053231.32581081
34Herpes simplex infection_Homo sapiens_hsa051681.31721459
35Chemokine signaling pathway_Homo sapiens_hsa040621.30670395
36Viral myocarditis_Homo sapiens_hsa054161.21766990
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.21608531
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20207996
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18011771
40Salmonella infection_Homo sapiens_hsa051321.17783537
41Hepatitis B_Homo sapiens_hsa051611.13997060
42Chronic myeloid leukemia_Homo sapiens_hsa052201.12860435
43Small cell lung cancer_Homo sapiens_hsa052221.12626500
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12087198
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09957992
46Shigellosis_Homo sapiens_hsa051311.07380633
47Type I diabetes mellitus_Homo sapiens_hsa049401.04724307
48Adherens junction_Homo sapiens_hsa045201.03531420
49Acute myeloid leukemia_Homo sapiens_hsa052211.03510872
50Pancreatic cancer_Homo sapiens_hsa052120.99945923
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99261996
52Amoebiasis_Homo sapiens_hsa051460.98207191
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95604659
54Notch signaling pathway_Homo sapiens_hsa043300.92062003
55Lysosome_Homo sapiens_hsa041420.90522372
56MicroRNAs in cancer_Homo sapiens_hsa052060.88554565
57Proteoglycans in cancer_Homo sapiens_hsa052050.85863538
58HTLV-I infection_Homo sapiens_hsa051660.85706467
59Hepatitis C_Homo sapiens_hsa051600.84316388
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84122682
61Phagosome_Homo sapiens_hsa041450.82721689
62Proteasome_Homo sapiens_hsa030500.80390970
63Epstein-Barr virus infection_Homo sapiens_hsa051690.79566569
64Prostate cancer_Homo sapiens_hsa052150.77605723
65Renal cell carcinoma_Homo sapiens_hsa052110.77600082
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.77271591
67VEGF signaling pathway_Homo sapiens_hsa043700.75376545
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70566873
69Platelet activation_Homo sapiens_hsa046110.70105051
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69918198
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67902287
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66400109
73Viral carcinogenesis_Homo sapiens_hsa052030.66342343
74Dorso-ventral axis formation_Homo sapiens_hsa043200.66301624
75Pathways in cancer_Homo sapiens_hsa052000.64536650
76Other glycan degradation_Homo sapiens_hsa005110.64372147
77HIF-1 signaling pathway_Homo sapiens_hsa040660.63061993
78Phototransduction_Homo sapiens_hsa047440.62422241
79Vitamin digestion and absorption_Homo sapiens_hsa049770.62004881
80Prolactin signaling pathway_Homo sapiens_hsa049170.62000554
81mTOR signaling pathway_Homo sapiens_hsa041500.61529580
82TGF-beta signaling pathway_Homo sapiens_hsa043500.61504663
83Colorectal cancer_Homo sapiens_hsa052100.61052786
84Focal adhesion_Homo sapiens_hsa045100.58535314
85Circadian rhythm_Homo sapiens_hsa047100.57334532
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57262212
87p53 signaling pathway_Homo sapiens_hsa041150.56954135
88FoxO signaling pathway_Homo sapiens_hsa040680.55314502
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53720122
90MAPK signaling pathway_Homo sapiens_hsa040100.53217480
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52246701
92Insulin resistance_Homo sapiens_hsa049310.49575720
93Rap1 signaling pathway_Homo sapiens_hsa040150.48963657
94Basal cell carcinoma_Homo sapiens_hsa052170.48641361
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48183504
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47776765
97Systemic lupus erythematosus_Homo sapiens_hsa053220.46900625
98Non-small cell lung cancer_Homo sapiens_hsa052230.44606945
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44091675
100Endocytosis_Homo sapiens_hsa041440.43870455
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.41505947
102ECM-receptor interaction_Homo sapiens_hsa045120.40909559
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.40661527
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.39548972
105Type II diabetes mellitus_Homo sapiens_hsa049300.37980155
106Ras signaling pathway_Homo sapiens_hsa040140.37881153
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37638540
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36604778
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35317550
110Prion diseases_Homo sapiens_hsa050200.35306859
111Melanoma_Homo sapiens_hsa052180.32444774
112Collecting duct acid secretion_Homo sapiens_hsa049660.30306266
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26909990
114Ether lipid metabolism_Homo sapiens_hsa005650.21218039
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20908375
116Linoleic acid metabolism_Homo sapiens_hsa005910.19650578
117Sphingolipid metabolism_Homo sapiens_hsa006000.19246796
118RNA degradation_Homo sapiens_hsa030180.13672434
119Nitrogen metabolism_Homo sapiens_hsa009100.13593656
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12717997
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.12423609

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