PRCC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.87517661
2Golgi transport vesicle coating (GO:0048200)4.69170101
3COPI coating of Golgi vesicle (GO:0048205)4.69170101
4regulation of translational fidelity (GO:0006450)4.62202619
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.55546335
6regulation of gene silencing by RNA (GO:0060966)4.37504470
7regulation of posttranscriptional gene silencing (GO:0060147)4.37504470
8regulation of gene silencing by miRNA (GO:0060964)4.37504470
9heterochromatin organization (GO:0070828)4.34676696
10proline biosynthetic process (GO:0006561)4.11167067
11regulation of hippo signaling (GO:0035330)4.05690432
12DNA unwinding involved in DNA replication (GO:0006268)4.03941399
13establishment of apical/basal cell polarity (GO:0035089)3.96443749
14regulation of translational termination (GO:0006449)3.95149923
15nuclear pore organization (GO:0006999)3.88603997
16spliceosomal tri-snRNP complex assembly (GO:0000244)3.83316002
17protein localization to kinetochore (GO:0034501)3.78797903
18nuclear pore complex assembly (GO:0051292)3.78735214
19mitotic G1 DNA damage checkpoint (GO:0031571)3.77623669
20maternal placenta development (GO:0001893)3.71795663
21negative regulation of cell size (GO:0045792)3.63492215
22intracellular estrogen receptor signaling pathway (GO:0030520)3.62762357
23folic acid-containing compound biosynthetic process (GO:0009396)3.60269230
24apoptotic process involved in morphogenesis (GO:0060561)3.59061684
25mitotic nuclear envelope reassembly (GO:0007084)3.56741005
26nuclear envelope reassembly (GO:0031468)3.56741005
27regulation of RNA export from nucleus (GO:0046831)3.54938992
28peptidyl-arginine omega-N-methylation (GO:0035247)3.50276086
29polarized epithelial cell differentiation (GO:0030859)3.48397358
30negative regulation of histone methylation (GO:0031061)3.47280615
31mitotic nuclear envelope disassembly (GO:0007077)3.44657150
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44423524
33chromatin assembly (GO:0031497)3.41067064
34positive regulation of SMAD protein import into nucleus (GO:0060391)3.40493264
35RNA stabilization (GO:0043489)3.38292425
36mRNA stabilization (GO:0048255)3.38292425
37protein complex localization (GO:0031503)3.34307618
38establishment or maintenance of monopolar cell polarity (GO:0061339)3.32486278
39establishment of monopolar cell polarity (GO:0061162)3.32486278
40trophectodermal cell differentiation (GO:0001829)3.31698288
41nuclear envelope disassembly (GO:0051081)3.31204624
42membrane disassembly (GO:0030397)3.31204624
43mitotic G1/S transition checkpoint (GO:0044819)3.31154056
44sister chromatid segregation (GO:0000819)3.29932636
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27944354
46dosage compensation (GO:0007549)3.27763804
47mitotic sister chromatid segregation (GO:0000070)3.26773197
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25580603
49G1 DNA damage checkpoint (GO:0044783)3.24438303
50paraxial mesoderm development (GO:0048339)3.24114031
51protein retention in ER lumen (GO:0006621)3.23464196
52formation of translation preinitiation complex (GO:0001731)3.20223043
53pentose-phosphate shunt (GO:0006098)3.18841110
54peptidyl-lysine dimethylation (GO:0018027)3.17755690
55negative regulation of erythrocyte differentiation (GO:0045647)3.16030636
56DNA strand elongation involved in DNA replication (GO:0006271)3.16027794
57NLS-bearing protein import into nucleus (GO:0006607)3.15925492
58peptidyl-arginine N-methylation (GO:0035246)3.15348617
59peptidyl-arginine methylation (GO:0018216)3.15348617
60DNA strand elongation (GO:0022616)3.14123242
61positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.12587181
62establishment of integrated proviral latency (GO:0075713)3.09891498
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08160985
64protein localization to chromosome, centromeric region (GO:0071459)3.04694814
65regulation of sister chromatid cohesion (GO:0007063)3.04538482
66cellular protein complex localization (GO:0034629)3.02920897
67positive regulation of chromosome segregation (GO:0051984)3.02165589
68positive regulation of histone deacetylation (GO:0031065)3.01954877
69regulation of SMAD protein import into nucleus (GO:0060390)3.00021674
70DNA replication initiation (GO:0006270)2.97881541
71adherens junction assembly (GO:0034333)2.97441192
72histone H2A monoubiquitination (GO:0035518)2.97313268
73protein maturation by protein folding (GO:0022417)2.96120761
74DNA duplex unwinding (GO:0032508)2.95596468
75rRNA transcription (GO:0009303)2.94820211
76negative regulation of mRNA processing (GO:0050686)2.94752936
77mitotic chromosome condensation (GO:0007076)2.94146012
78glucocorticoid receptor signaling pathway (GO:0042921)2.94079318
79mitotic metaphase plate congression (GO:0007080)2.92174007
80nuclear envelope organization (GO:0006998)2.91055778
81DNA geometric change (GO:0032392)2.90988428
82regulation of histone H3-K9 methylation (GO:0051570)2.88084947
83negative regulation of RNA splicing (GO:0033119)2.87665644
843-UTR-mediated mRNA stabilization (GO:0070935)2.85031623
85negative regulation of mRNA metabolic process (GO:1903312)2.84989832
86mitochondrial fusion (GO:0008053)2.84137658
87regulation of nucleobase-containing compound transport (GO:0032239)2.83442466
88regulation of chromatin binding (GO:0035561)2.80479275
89snRNA metabolic process (GO:0016073)2.79204814
90GDP-mannose metabolic process (GO:0019673)2.77589879
91histone H4-K12 acetylation (GO:0043983)2.77214202
92cell-substrate adherens junction assembly (GO:0007045)2.76125837
93focal adhesion assembly (GO:0048041)2.76125837
94DNA replication-dependent nucleosome assembly (GO:0006335)2.76043902
95DNA replication-dependent nucleosome organization (GO:0034723)2.76043902
96NADPH regeneration (GO:0006740)2.75581560
97chromatin silencing (GO:0006342)2.75244706
98establishment of viral latency (GO:0019043)2.74166848
99IMP biosynthetic process (GO:0006188)2.73868706
100negative regulation of glial cell proliferation (GO:0060253)2.73374715
101ribosome biogenesis (GO:0042254)2.73121599
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.72476113
103modulation by virus of host process (GO:0019054)2.72368396
104anterior/posterior axis specification, embryo (GO:0008595)2.71750708
105pore complex assembly (GO:0046931)2.71024848
106histone arginine methylation (GO:0034969)2.70564414
107proline metabolic process (GO:0006560)2.69571675
108positive regulation of RNA splicing (GO:0033120)2.66563033
109apoptotic process involved in development (GO:1902742)2.66443239
110ribosomal small subunit biogenesis (GO:0042274)2.66346993
111NIK/NF-kappaB signaling (GO:0038061)2.65812900
112regulation of mRNA stability (GO:0043488)2.64795323
113negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.64082615
114regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.61997139
115positive regulation of nuclease activity (GO:0032075)2.61397058
116hippo signaling (GO:0035329)2.60989667
117glucose catabolic process (GO:0006007)2.60977748
118negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60896576
119protein export from nucleus (GO:0006611)2.60638090
120activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58702196
121regulation of NFAT protein import into nucleus (GO:0051532)2.58307673
122positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58276428
123positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58276428
124positive regulation of mitotic sister chromatid separation (GO:1901970)2.58276428
125gene silencing (GO:0016458)2.57981052
126NADH metabolic process (GO:0006734)2.57767576
127activation of Rac GTPase activity (GO:0032863)2.57707330
128telomere maintenance via semi-conservative replication (GO:0032201)2.57548959
129modulation by symbiont of host cellular process (GO:0044068)2.57399571
130DNA topological change (GO:0006265)2.57294520
131negative regulation of potassium ion transmembrane transport (GO:1901380)2.55776165
132RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.55614167
133mRNA splicing, via spliceosome (GO:0000398)2.55614167
134glucose 6-phosphate metabolic process (GO:0051156)2.55386185
135regulation of glucose import in response to insulin stimulus (GO:2001273)2.54681174
136establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.53816307
137folic acid metabolic process (GO:0046655)2.52895386
138regulation of translational elongation (GO:0006448)2.52101117
139regulation of early endosome to late endosome transport (GO:2000641)2.51675162
140embryonic process involved in female pregnancy (GO:0060136)2.51454853
141regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.50673509
142positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.50673509
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49740773
144protein localization to endosome (GO:0036010)2.49095206
145nucleosome disassembly (GO:0006337)2.48457544
146protein-DNA complex disassembly (GO:0032986)2.48457544
147nucleobase-containing small molecule interconversion (GO:0015949)2.48316753
148negative regulation of nucleotide catabolic process (GO:0030812)2.47952880
149RNA splicing, via transesterification reactions (GO:0000375)2.47847350
150negative regulation of viral release from host cell (GO:1902187)2.47793145
151cellular hyperosmotic response (GO:0071474)2.47557396
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.46691053
153negative regulation of gene expression, epigenetic (GO:0045814)2.46380613
154regulation of RNA stability (GO:0043487)2.45461029
155regulation of gene silencing (GO:0060968)2.45200333
156chromosome condensation (GO:0030261)2.44694650
157pentose metabolic process (GO:0019321)2.41886447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.27608234
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.39159419
3* MYC_22102868_ChIP-Seq_BL_Human3.31081018
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87025051
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75832218
6* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75539452
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.63149135
8ZNF263_19887448_ChIP-Seq_K562_Human2.35384642
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.30007169
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19765206
11VDR_21846776_ChIP-Seq_THP-1_Human2.16324028
12KDM2B_26808549_Chip-Seq_DND41_Human2.11128500
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09707243
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08841912
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07672250
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97955548
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95632597
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95365743
19TCF7_22412390_ChIP-Seq_EML_Mouse1.93962120
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92671403
21* ELK3_25401928_ChIP-Seq_HUVEC_Human1.88187093
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86583711
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85612516
24* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84686684
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82217078
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81049189
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73571905
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71876051
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64464328
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63099553
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62652224
32LXR_22292898_ChIP-Seq_THP-1_Human1.62591282
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62322810
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58034127
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57454154
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56411015
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55422217
38* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53677662
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53023543
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.51921879
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51581299
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50222154
43* ATF3_27146783_Chip-Seq_COLON_Human1.48720574
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48658958
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46388594
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46388594
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46388594
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46308316
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45995378
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.45913069
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45001414
52* XRN2_22483619_ChIP-Seq_HELA_Human1.44076349
53* NANOG_21062744_ChIP-ChIP_HESCs_Human1.44065432
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43318936
55* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43285379
56AR_21909140_ChIP-Seq_LNCAP_Human1.41452199
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38365431
58* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35823260
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.35200140
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34838608
61* DCP1A_22483619_ChIP-Seq_HELA_Human1.34294532
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.33642385
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32300520
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.31716995
65* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31299852
66* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30280279
67GABP_19822575_ChIP-Seq_HepG2_Human1.29284997
68UTX_26944678_Chip-Seq_JUKART_Human1.28590516
69* ETS1_20019798_ChIP-Seq_JURKAT_Human1.28242019
70MAF_26560356_Chip-Seq_TH1_Human1.27957184
71CIITA_25753668_ChIP-Seq_RAJI_Human1.27928914
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.26995168
73CLOCK_20551151_ChIP-Seq_293T_Human1.25160564
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24481088
75KDM2B_26808549_Chip-Seq_K562_Human1.24253717
76CREB1_26743006_Chip-Seq_LNCaP_Human1.24029639
77* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23907479
78* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23720140
79* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21686838
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21303571
81* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19800463
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.19787589
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19711401
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.19665420
85* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19637576
86* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19302743
87* TTF2_22483619_ChIP-Seq_HELA_Human1.18783442
88* NCOR1_26117541_ChIP-Seq_K562_Human1.18492543
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18428128
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18138877
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17915062
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17899180
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17154657
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16988762
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16869450
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16810895
97* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16125488
98P68_20966046_ChIP-Seq_HELA_Human1.16077504
99VDR_24763502_ChIP-Seq_THP-1_Human1.14106312
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14080443
101* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13847021
102MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13527185
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12635095
104* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12602233
105* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12065692
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11486284
107* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11086679
108* CHD1_26751641_Chip-Seq_LNCaP_Human1.10107661
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10051090
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09798096
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07742274
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07706102
113OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07306487
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06966907
115TFEB_21752829_ChIP-Seq_HELA_Human1.06072841
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05623434
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05498708
118* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05406671
119* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04703314
120GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03374039
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03199656
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01951575
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01832239
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00893930
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00047226
126MAF_26560356_Chip-Seq_TH2_Human0.99809331
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99718483
128SMC4_20622854_ChIP-Seq_HELA_Human0.99092170
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98694674
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98599268
131TP53_22127205_ChIP-Seq_IMR90_Human0.97806598
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96611626
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.95744173
134* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95092634
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94397162
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94111682
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93928121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.44810482
2MP0005076_abnormal_cell_differentiation3.21326549
3MP0005451_abnormal_body_composition3.20448608
4MP0010352_gastrointestinal_tract_polyps3.12941126
5MP0003111_abnormal_nucleus_morphology2.66607027
6MP0004957_abnormal_blastocyst_morpholog2.55137200
7MP0008260_abnormal_autophagy2.45959414
8MP0001730_embryonic_growth_arrest2.40316706
9MP0005058_abnormal_lysosome_morphology2.24081810
10MP0003077_abnormal_cell_cycle2.17605700
11MP0009278_abnormal_bone_marrow2.13210778
12MP0004197_abnormal_fetal_growth/weight/2.13078510
13MP0004185_abnormal_adipocyte_glucose2.11155665
14MP0010030_abnormal_orbit_morphology2.10339997
15MP0010307_abnormal_tumor_latency2.02659667
16MP0000537_abnormal_urethra_morphology1.99561016
17MP0003123_paternal_imprinting1.99354456
18MP0003693_abnormal_embryo_hatching1.98068787
19MP0001672_abnormal_embryogenesis/_devel1.97933623
20MP0005380_embryogenesis_phenotype1.97933623
21MP0002084_abnormal_developmental_patter1.97025541
22MP0000678_abnormal_parathyroid_gland1.94541786
23MP0000350_abnormal_cell_proliferation1.94359273
24MP0003984_embryonic_growth_retardation1.91776301
25MP0010234_abnormal_vibrissa_follicle1.91142232
26MP0002088_abnormal_embryonic_growth/wei1.90014835
27MP0002086_abnormal_extraembryonic_tissu1.86590975
28MP0001849_ear_inflammation1.85902576
29MP0003283_abnormal_digestive_organ1.84201974
30MP0004233_abnormal_muscle_weight1.83735130
31MP0009053_abnormal_anal_canal1.83197452
32MP0010094_abnormal_chromosome_stability1.83177414
33MP0001697_abnormal_embryo_size1.83091945
34MP0008057_abnormal_DNA_replication1.81458274
35MP0002653_abnormal_ependyma_morphology1.80205885
36MP0002085_abnormal_embryonic_tissue1.79178502
37MP0000733_abnormal_muscle_development1.78246332
38MP0003119_abnormal_digestive_system1.77915835
39MP0002796_impaired_skin_barrier1.77759902
40MP0003566_abnormal_cell_adhesion1.75305455
41MP0009333_abnormal_splenocyte_physiolog1.73858861
42MP0002080_prenatal_lethality1.62781817
43MP0002249_abnormal_larynx_morphology1.55089133
44MP0008961_abnormal_basal_metabolism1.53919475
45MP0003567_abnormal_fetal_cardiomyocyte1.49571839
46MP0002269_muscular_atrophy1.40947450
47MP0009840_abnormal_foam_cell1.40858455
48MP0008058_abnormal_DNA_repair1.40429800
49MP0002877_abnormal_melanocyte_morpholog1.37484910
50MP0010630_abnormal_cardiac_muscle1.37094035
51MP0001346_abnormal_lacrimal_gland1.36968908
52MP0004087_abnormal_muscle_fiber1.36308762
53MP0003303_peritoneal_inflammation1.34795310
54MP0005623_abnormal_meninges_morphology1.33802320
55MP0000747_muscle_weakness1.33553924
56MP0003890_abnormal_embryonic-extraembry1.32994616
57MP0003115_abnormal_respiratory_system1.32367406
58MP0000750_abnormal_muscle_regeneration1.30509248
59MP0000428_abnormal_craniofacial_morphol1.27896139
60MP0001293_anophthalmia1.27393579
61MP0009672_abnormal_birth_weight1.26365711
62MP0003221_abnormal_cardiomyocyte_apopto1.22587678
63MP0005666_abnormal_adipose_tissue1.22333086
64MP0004084_abnormal_cardiac_muscle1.21338492
65MP0002925_abnormal_cardiovascular_devel1.14330362
66MP0000858_altered_metastatic_potential1.12466558
67MP0008770_decreased_survivor_rate1.12221364
68MP0005023_abnormal_wound_healing1.11706866
69MP0003300_gastrointestinal_ulcer1.10850948
70MP0002092_abnormal_eye_morphology1.10640378
71MP0009703_decreased_birth_body1.08815567
72MP0002697_abnormal_eye_size1.05164008
73MP0000751_myopathy1.04836747
74MP0005375_adipose_tissue_phenotype1.04328573
75MP0005397_hematopoietic_system_phenotyp1.03572782
76MP0001545_abnormal_hematopoietic_system1.03572782
77MP0000266_abnormal_heart_morphology1.02738796
78MP0003436_decreased_susceptibility_to1.02477021
79MP0005330_cardiomyopathy1.01297941
80MP0003763_abnormal_thymus_physiology1.01166234
81MP0008932_abnormal_embryonic_tissue0.98701066
82MP0000759_abnormal_skeletal_muscle0.98625244
83MP0001915_intracranial_hemorrhage0.97654720
84MP0005384_cellular_phenotype0.97354027
85MP0002111_abnormal_tail_morphology0.94063302
86MP0004858_abnormal_nervous_system0.93412647
87MP0009931_abnormal_skin_appearance0.93345714
88MP0000313_abnormal_cell_death0.89888841
89MP0002089_abnormal_postnatal_growth/wei0.89787124
90MP0004130_abnormal_muscle_cell0.89246420
91MP0002019_abnormal_tumor_incidence0.88035796
92MP0000003_abnormal_adipose_tissue0.87801421
93MP0003315_abnormal_perineum_morphology0.87775047
94MP0004264_abnormal_extraembryonic_tissu0.87536031
95MP0002396_abnormal_hematopoietic_system0.87043148
96MP0008007_abnormal_cellular_replicative0.86988586
97MP0001661_extended_life_span0.86087954
98MP0003453_abnormal_keratinocyte_physiol0.84733344
99MP0000681_abnormal_thyroid_gland0.84546587
100MP0002106_abnormal_muscle_physiology0.84383956
101MP0001727_abnormal_embryo_implantation0.82892312
102MP0003935_abnormal_craniofacial_develop0.82374021
103MP0002398_abnormal_bone_marrow0.82250976
104MP0001784_abnormal_fluid_regulation0.81930893
105MP0000490_abnormal_crypts_of0.81609363
106MP0003861_abnormal_nervous_system0.80040828
107MP0003091_abnormal_cell_migration0.79537675
108MP0004510_myositis0.79440912
109MP0000358_abnormal_cell_content/0.78930745
110MP0000534_abnormal_ureter_morphology0.78477205
111MP0004808_abnormal_hematopoietic_stem0.77693074
112MP0004947_skin_inflammation0.77435150
113MP0000467_abnormal_esophagus_morphology0.76879645
114MP0003942_abnormal_urinary_system0.75956729
115MP0003121_genomic_imprinting0.74897667
116MP0004133_heterotaxia0.74051047
117MP0000566_synostosis0.73337944
118MP0004145_abnormal_muscle_electrophysio0.72780940
119MP0003172_abnormal_lysosome_physiology0.72660559
120MP0002060_abnormal_skin_morphology0.72422183
121MP0002722_abnormal_immune_system0.71728896
122MP0003786_premature_aging0.71672686
123MP0005621_abnormal_cell_physiology0.68106179
124MP0001348_abnormal_lacrimal_gland0.68072739
125MP0000477_abnormal_intestine_morphology0.67805696
126MP0000703_abnormal_thymus_morphology0.67111042
127MP0003646_muscle_fatigue0.66309356
128MP0002429_abnormal_blood_cell0.66069398
129MP0002932_abnormal_joint_morphology0.65875368
130MP0001216_abnormal_epidermal_layer0.65097065
131MP0005501_abnormal_skin_physiology0.64541751

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)3.75093159
2Abnormal gallbladder physiology (HP:0012438)3.75093159
3Ependymoma (HP:0002888)3.57160852
4Progressive muscle weakness (HP:0003323)3.43898695
5Abnormality of the lower motor neuron (HP:0002366)3.04948041
6Centrally nucleated skeletal muscle fibers (HP:0003687)3.03708103
7Astrocytoma (HP:0009592)3.02273038
8Abnormality of the astrocytes (HP:0100707)3.02273038
9Ragged-red muscle fibers (HP:0003200)2.88848465
10Hyperacusis (HP:0010780)2.87882007
11Ulnar bowing (HP:0003031)2.81739310
12Distal lower limb amyotrophy (HP:0008944)2.81202176
13Long palpebral fissure (HP:0000637)2.79993592
14Cerebral aneurysm (HP:0004944)2.76238662
15Microvesicular hepatic steatosis (HP:0001414)2.73555305
16Difficulty climbing stairs (HP:0003551)2.62705918
17Broad distal phalanx of finger (HP:0009836)2.61473377
18Pseudobulbar signs (HP:0002200)2.57433797
19Increased connective tissue (HP:0009025)2.56837560
20Myopathic facies (HP:0002058)2.51400451
21Distal lower limb muscle weakness (HP:0009053)2.49619323
22Shallow orbits (HP:0000586)2.46557195
23Vertebral compression fractures (HP:0002953)2.46525877
24Exercise-induced muscle cramps (HP:0003710)2.45408288
25Adenoma sebaceum (HP:0009720)2.45028480
26Angiofibromas (HP:0010615)2.45028480
27Septate vagina (HP:0001153)2.43114260
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42159537
29Short 4th metacarpal (HP:0010044)2.42159537
30Achilles tendon contracture (HP:0001771)2.39988674
31Distal upper limb amyotrophy (HP:0007149)2.39456562
32Upper limb amyotrophy (HP:0009129)2.39456562
33Genu recurvatum (HP:0002816)2.34663937
34Sparse lateral eyebrow (HP:0005338)2.34450198
35Multiple enchondromatosis (HP:0005701)2.33213940
36Hand muscle atrophy (HP:0009130)2.31829631
37Difficulty running (HP:0009046)2.29313281
38Metaphyseal cupping (HP:0003021)2.27094455
39Abnormality of the Achilles tendon (HP:0005109)2.26977529
40Abnormality of the phalanges of the hallux (HP:0010057)2.24700361
41Abnormality of the 4th metacarpal (HP:0010012)2.24253660
42Increased nuchal translucency (HP:0010880)2.23902919
43Selective tooth agenesis (HP:0001592)2.23090945
44Abnormality of the umbilical cord (HP:0010881)2.21332122
45Hypercortisolism (HP:0001578)2.20093439
46Renal duplication (HP:0000075)2.19584917
47Fibroma (HP:0010614)2.18636306
48Abnormality of the fetal cardiovascular system (HP:0010948)2.16062615
49Abnormal umbilical cord blood vessels (HP:0011403)2.16062615
50Single umbilical artery (HP:0001195)2.16062615
51Heterotopia (HP:0002282)2.15505160
52Neoplasm of striated muscle (HP:0009728)2.15486216
53Spastic diplegia (HP:0001264)2.14924568
54Rough bone trabeculation (HP:0100670)2.14898034
55Disproportionate tall stature (HP:0001519)2.13440102
56Abnormality of the distal phalanges of the toes (HP:0010182)2.12965323
57Hyperparathyroidism (HP:0000843)2.12704717
58Basal cell carcinoma (HP:0002671)2.12175931
59Insomnia (HP:0100785)2.09967918
60Glioma (HP:0009733)2.09929739
61Protrusio acetabuli (HP:0003179)2.09615422
62Fibrous tissue neoplasm (HP:0012316)2.09113148
63Lymphangioma (HP:0100764)2.08915940
64Progressive external ophthalmoplegia (HP:0000590)2.06633372
65Gastrointestinal carcinoma (HP:0002672)2.06380838
66Malignant gastrointestinal tract tumors (HP:0006749)2.06380838
67Rectal prolapse (HP:0002035)2.05602458
68Hypertensive crisis (HP:0100735)2.04711452
69Truncus arteriosus (HP:0001660)2.02701468
70Ankle contracture (HP:0006466)2.01157752
71Broad thumb (HP:0011304)1.99218554
72Deviation of the thumb (HP:0009603)1.96889808
73Hyporeflexia of lower limbs (HP:0002600)1.96731484
74Testicular atrophy (HP:0000029)1.96108744
75Back pain (HP:0003418)1.95220763
76Rib fusion (HP:0000902)1.94920885
77Proximal placement of thumb (HP:0009623)1.93235604
78Shoulder girdle muscle weakness (HP:0003547)1.93103929
79EMG: neuropathic changes (HP:0003445)1.92993063
80Skin tags (HP:0010609)1.91779064
81Reticulocytosis (HP:0001923)1.91085684
82Muscle fiber splitting (HP:0003555)1.90560292
83Cholelithiasis (HP:0001081)1.90255639
84Subacute progressive viral hepatitis (HP:0006572)1.89877810
85Cellulitis (HP:0100658)1.89579457
86Broad face (HP:0000283)1.89010556
87Rhabdomyosarcoma (HP:0002859)1.88727875
88Mitral valve prolapse (HP:0001634)1.88698900
89Abnormality of the thoracic spine (HP:0100711)1.87212810
90Lower limb amyotrophy (HP:0007210)1.86703154
91Asymmetry of the thorax (HP:0001555)1.85733422
92Increased density of long bones (HP:0006392)1.84436999
93Turricephaly (HP:0000262)1.83118878
94Ulnar deviation of the wrist (HP:0003049)1.82243688
95Neoplasm of the oral cavity (HP:0100649)1.81724518
96Abnormality of skeletal muscle fiber size (HP:0012084)1.81293568
97Abnormality of the labia minora (HP:0012880)1.80633333
98Unilateral renal agenesis (HP:0000122)1.80308080
99Spinal muscular atrophy (HP:0007269)1.79816092
100Facial hemangioma (HP:0000329)1.79645707
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.77932563
102Abnormality of the calcaneus (HP:0008364)1.77903299
103Patellar dislocation (HP:0002999)1.76929007
104Obstructive sleep apnea (HP:0002870)1.76338636
105Dysmetric saccades (HP:0000641)1.76157849
106Elfin facies (HP:0004428)1.75567212
107Generalized amyotrophy (HP:0003700)1.74550604
108Annular pancreas (HP:0001734)1.74201465
109Biconcave vertebral bodies (HP:0004586)1.73884650
110Aneurysm (HP:0002617)1.73713578
111Enlarged penis (HP:0000040)1.73238304
112Renovascular hypertension (HP:0100817)1.73107046
113Pointed chin (HP:0000307)1.72951716
114Vertebral clefting (HP:0008428)1.71398247
115Short phalanx of the thumb (HP:0009660)1.71198212
116Abnormality of the gallbladder (HP:0005264)1.71143811
117Trismus (HP:0000211)1.71142341
118Pelvic girdle muscle weakness (HP:0003749)1.70186432
119Premature rupture of membranes (HP:0001788)1.70005929
120Biliary tract neoplasm (HP:0100574)1.68641160
121Missing ribs (HP:0000921)1.68138829
122Vertebral fusion (HP:0002948)1.68083239
123Stridor (HP:0010307)1.67871564
124Preauricular skin tag (HP:0000384)1.67627695
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67603100
126Athetosis (HP:0002305)1.67445584
127Deep palmar crease (HP:0006191)1.67174563
128Bulbar palsy (HP:0001283)1.67141331
129Exercise-induced myalgia (HP:0003738)1.67086119
130Abnormality of the fingertips (HP:0001211)1.66670041
131Urethral obstruction (HP:0000796)1.66488473
132Increased variability in muscle fiber diameter (HP:0003557)1.66311264
133Short humerus (HP:0005792)1.66163294
134Breast hypoplasia (HP:0003187)1.65702250
135Overriding aorta (HP:0002623)1.65626828
136Fasciculations (HP:0002380)1.64536877
137Hallux valgus (HP:0001822)1.64219611
138Hypoparathyroidism (HP:0000829)1.63994367
139Upper motor neuron abnormality (HP:0002127)1.63810437
140Diaphragmatic weakness (HP:0009113)1.63738649
141Neuronal loss in central nervous system (HP:0002529)1.63641296
142Hamartoma of the eye (HP:0010568)1.63628783
143Macroorchidism (HP:0000053)1.63448094
144Intestinal polyp (HP:0005266)1.63092468
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62450261
146Medulloblastoma (HP:0002885)1.61769516
147Deviation of the hallux (HP:0010051)1.61614167
148Sudden death (HP:0001699)1.61450459
149Short 1st metacarpal (HP:0010034)1.61344201
150Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61344201
151Peripheral hypomyelination (HP:0007182)1.61339882
152Abnormal large intestine physiology (HP:0012700)1.61302028
153Polycythemia (HP:0001901)1.61124411
154Seborrheic dermatitis (HP:0001051)1.60943258
155Colon cancer (HP:0003003)1.60817216
156Short 5th finger (HP:0009237)1.59512922
157Abnormal trabecular bone morphology (HP:0100671)1.57870137
158Bowed forearm bones (HP:0003956)1.57848267
159Bowing of the arm (HP:0006488)1.57848267
160Cafe-au-lait spot (HP:0000957)1.57408041
161High anterior hairline (HP:0009890)1.56279815
162Aplasia/hypoplasia of the humerus (HP:0006507)1.54713488
163Flat acetabular roof (HP:0003180)1.54493836
164Spinal rigidity (HP:0003306)1.53282340
165Fatigue (HP:0012378)1.53248512
166Bowel incontinence (HP:0002607)1.53180917
167Premature skin wrinkling (HP:0100678)1.52921555
168Hammertoe (HP:0001765)1.52721391
169Long eyelashes (HP:0000527)1.51156230
170Overlapping toe (HP:0001845)1.50664485
171Thin ribs (HP:0000883)1.50295048
172Distal sensory impairment (HP:0002936)1.50262386
173Glossoptosis (HP:0000162)1.49506768
174Elbow flexion contracture (HP:0002987)1.49048299
175Microretrognathia (HP:0000308)1.48431177
176Self-mutilation (HP:0000742)1.48145142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.48028813
2SMG14.15656930
3MAP3K103.77615524
4EEF2K3.67330799
5PKN23.60830466
6CDK123.58211096
7PRPF4B3.11653611
8ICK2.86415200
9NME22.79861699
10IRAK32.71578084
11VRK22.65542227
12NEK22.10711480
13NEK11.96503680
14CDC71.95850462
15TTN1.90063296
16TAOK21.87673883
17ALK1.80212145
18TESK11.73787620
19SCYL21.72102451
20LATS21.70485687
21TYRO31.63075932
22PDGFRA1.54793566
23BMX1.54767714
24PTK61.48024881
25LATS11.47868094
26ERN11.47152064
27RIPK11.46599369
28ARAF1.41546575
29MTOR1.41442342
30RPS6KB21.38826106
31SIK31.38044582
32PIM21.35407771
33STK101.35352867
34CDK41.31020420
35PAK41.28647284
36BUB11.26847735
37SIK11.25767469
38LRRK21.23689551
39CDK61.19690447
40GRK61.19330608
41TAOK11.17746999
42DDR21.17644049
43MAP3K81.13607326
44KSR21.06308107
45TTK1.05491570
46SRPK11.04821446
47PRKD31.00948424
48EPHA20.95286891
49CDK70.92143141
50MAP3K30.89467141
51MAP3K90.87532990
52DMPK0.86538260
53CDK90.85705408
54EIF2AK10.85193664
55MAP4K10.83391794
56MAP3K110.82892743
57WEE10.82789985
58CHEK10.82770737
59SIK20.81039855
60BRAF0.80358667
61IRAK20.78549844
62MAP2K20.76175221
63CAMK1D0.74631970
64PAK20.72883757
65TESK20.72419939
66BRSK10.71891977
67MAP2K30.71121624
68CDK20.71018303
69KDR0.69461802
70PAK60.68897596
71TBK10.68325735
72PIM10.68325229
73KSR10.68141889
74MAP3K10.67946435
75AKT20.67206750
76ILK0.66444778
77CDK80.66301708
78STK40.66143923
79MARK20.65081764
80PLK10.64353448
81PTK20.64080558
82STK30.63959655
83PASK0.63486033
84RPS6KA10.62925004
85UHMK10.62505963
86FGFR10.62264301
87EPHB10.59538240
88RAF10.59322480
89FLT30.59239025
90DAPK10.58996404
91MAP3K70.58925525
92DYRK1B0.57898182
93IRAK40.57755305
94MAPK110.57564500
95PHKG20.56629151
96PHKG10.56629151
97RPS6KA40.55926640
98CHEK20.54905449
99DYRK30.54581860
100AURKB0.53852923
101RPS6KA20.53813583
102TSSK60.52241902
103STK380.51978110
104CDC42BPA0.51719407
105CAMK1G0.51045362
106RIPK40.49217379
107PDGFRB0.49195419
108MELK0.48726282
109AURKA0.48485702
110CDK11A0.48064742
111MAP3K60.47841781
112CSNK1E0.47432634
113LIMK10.45221248
114RET0.45206314
115BCKDK0.44371766
116ATR0.44328236
117FGFR40.44026319
118PDPK10.43757461
119PRKAA10.43737218
120PBK0.43705291
121NME10.42931219
122GSK3A0.42603431
123CDK150.42194508
124NTRK10.41887594
125RPS6KC10.41714329
126RPS6KL10.41714329
127BRD40.41610936
128FGFR30.40400940
129MET0.40296116
130ATM0.39920452
131MARK30.39297177
132PRKD20.38853025
133CDK140.38561507
134CDK180.38464099
135CDK10.37988672
136PAK10.37773648
137CSNK1D0.37688315
138CSK0.36456819
139HIPK20.35438656
140MATK0.35300051
141MAPKAPK20.34796774
142TAF10.34555825
143RPS6KA60.33044039

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.26077368
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18092986
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09427991
4mTOR signaling pathway_Homo sapiens_hsa041502.04686193
5mRNA surveillance pathway_Homo sapiens_hsa030152.00945338
6Chronic myeloid leukemia_Homo sapiens_hsa052201.84338200
7DNA replication_Homo sapiens_hsa030301.82745067
8Spliceosome_Homo sapiens_hsa030401.81509515
9Notch signaling pathway_Homo sapiens_hsa043301.78827091
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77724328
11Lysine degradation_Homo sapiens_hsa003101.72367883
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.68972724
13Biosynthesis of amino acids_Homo sapiens_hsa012301.66842227
14Cell cycle_Homo sapiens_hsa041101.65493307
15Bladder cancer_Homo sapiens_hsa052191.62647723
16Nitrogen metabolism_Homo sapiens_hsa009101.62153679
17One carbon pool by folate_Homo sapiens_hsa006701.60406799
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53613228
19Hippo signaling pathway_Homo sapiens_hsa043901.52954780
20MicroRNAs in cancer_Homo sapiens_hsa052061.51398491
21Basal cell carcinoma_Homo sapiens_hsa052171.49121016
22Mismatch repair_Homo sapiens_hsa034301.45155904
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42218783
24Non-small cell lung cancer_Homo sapiens_hsa052231.38884206
25Other glycan degradation_Homo sapiens_hsa005111.37486878
26Endometrial cancer_Homo sapiens_hsa052131.36489553
27Base excision repair_Homo sapiens_hsa034101.35856492
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33733597
29Adherens junction_Homo sapiens_hsa045201.31752022
30Colorectal cancer_Homo sapiens_hsa052101.29973159
31Prion diseases_Homo sapiens_hsa050201.28908931
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28508621
33Small cell lung cancer_Homo sapiens_hsa052221.27987873
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27089420
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.25609016
36Thyroid cancer_Homo sapiens_hsa052161.24155442
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23758451
38Proteoglycans in cancer_Homo sapiens_hsa052051.23173095
39Pyrimidine metabolism_Homo sapiens_hsa002401.22567536
40Galactose metabolism_Homo sapiens_hsa000521.22502754
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20936916
42VEGF signaling pathway_Homo sapiens_hsa043701.18844760
43Viral carcinogenesis_Homo sapiens_hsa052031.17209973
44Carbon metabolism_Homo sapiens_hsa012001.15209193
45Arginine biosynthesis_Homo sapiens_hsa002201.15138732
46AMPK signaling pathway_Homo sapiens_hsa041521.15015484
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14720809
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14082314
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13209738
50Acute myeloid leukemia_Homo sapiens_hsa052211.12770411
51Hedgehog signaling pathway_Homo sapiens_hsa043401.11372111
52Glioma_Homo sapiens_hsa052141.09867433
53Renal cell carcinoma_Homo sapiens_hsa052111.09411540
54Dorso-ventral axis formation_Homo sapiens_hsa043201.08367880
55Insulin signaling pathway_Homo sapiens_hsa049101.07983170
56Vibrio cholerae infection_Homo sapiens_hsa051101.06832713
57HTLV-I infection_Homo sapiens_hsa051661.05751674
58Insulin resistance_Homo sapiens_hsa049311.05263472
59Oocyte meiosis_Homo sapiens_hsa041141.04357014
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.03498331
61Fatty acid biosynthesis_Homo sapiens_hsa000611.01573440
62Viral myocarditis_Homo sapiens_hsa054160.99564904
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99133566
64Sulfur relay system_Homo sapiens_hsa041220.98947394
65Shigellosis_Homo sapiens_hsa051310.98673442
66Focal adhesion_Homo sapiens_hsa045100.97922084
67Ribosome_Homo sapiens_hsa030100.97672611
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96161295
69Tight junction_Homo sapiens_hsa045300.96057688
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93228543
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92081788
72Non-homologous end-joining_Homo sapiens_hsa034500.91799044
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90397070
74p53 signaling pathway_Homo sapiens_hsa041150.89547866
75Pancreatic cancer_Homo sapiens_hsa052120.88987560
76Glucagon signaling pathway_Homo sapiens_hsa049220.86788333
77Herpes simplex infection_Homo sapiens_hsa051680.85922208
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85508642
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84609461
80HIF-1 signaling pathway_Homo sapiens_hsa040660.82746282
81Estrogen signaling pathway_Homo sapiens_hsa049150.82120641
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.75578345
83Selenocompound metabolism_Homo sapiens_hsa004500.74946484
84N-Glycan biosynthesis_Homo sapiens_hsa005100.74451130
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73340162
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73148606
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72397106
88Pentose phosphate pathway_Homo sapiens_hsa000300.71681928
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71585094
90Prostate cancer_Homo sapiens_hsa052150.70248960
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68264128
92TGF-beta signaling pathway_Homo sapiens_hsa043500.67153954
93Wnt signaling pathway_Homo sapiens_hsa043100.66987636
94Pathways in cancer_Homo sapiens_hsa052000.66424969
95Hepatitis C_Homo sapiens_hsa051600.65664411
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65111189
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64571084
98Vitamin B6 metabolism_Homo sapiens_hsa007500.64295931
99RNA polymerase_Homo sapiens_hsa030200.64152908
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63624280
101B cell receptor signaling pathway_Homo sapiens_hsa046620.62456886
102FoxO signaling pathway_Homo sapiens_hsa040680.61840056
103Folate biosynthesis_Homo sapiens_hsa007900.61282925
104Phenylalanine metabolism_Homo sapiens_hsa003600.60055735
105Influenza A_Homo sapiens_hsa051640.59366568
106Dilated cardiomyopathy_Homo sapiens_hsa054140.58456729
107Apoptosis_Homo sapiens_hsa042100.58185998
108ErbB signaling pathway_Homo sapiens_hsa040120.56103701
109Prolactin signaling pathway_Homo sapiens_hsa049170.55339931
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55041854
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53686262
112Hepatitis B_Homo sapiens_hsa051610.52638244
113Proteasome_Homo sapiens_hsa030500.52376979
114Systemic lupus erythematosus_Homo sapiens_hsa053220.50778861
115Nucleotide excision repair_Homo sapiens_hsa034200.50206310
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50143633
117* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49027635
118Antigen processing and presentation_Homo sapiens_hsa046120.48954212
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.48787464
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.48356591
121Epstein-Barr virus infection_Homo sapiens_hsa051690.48354148
122Endocytosis_Homo sapiens_hsa041440.47511570
123Fructose and mannose metabolism_Homo sapiens_hsa000510.47179061
124Amoebiasis_Homo sapiens_hsa051460.46296211
125Type II diabetes mellitus_Homo sapiens_hsa049300.46115519
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46015212
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44772614
128Salmonella infection_Homo sapiens_hsa051320.43574822
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43226968
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.39923925
131Inositol phosphate metabolism_Homo sapiens_hsa005620.37954589

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