PRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.42633395
2mitotic metaphase plate congression (GO:0007080)6.06208213
3protein localization to chromosome, centromeric region (GO:0071459)5.66080777
4mitotic sister chromatid segregation (GO:0000070)5.65136532
5kinetochore organization (GO:0051383)5.59170005
6mitotic chromosome condensation (GO:0007076)5.52793811
7metaphase plate congression (GO:0051310)5.44122536
8sister chromatid segregation (GO:0000819)5.39290780
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.33085959
10attachment of spindle microtubules to kinetochore (GO:0008608)5.32915057
11regulation of spindle organization (GO:0090224)5.27042605
12establishment of chromosome localization (GO:0051303)4.97898821
13CENP-A containing nucleosome assembly (GO:0034080)4.88172076
14kinetochore assembly (GO:0051382)4.85431559
15chromatin remodeling at centromere (GO:0031055)4.76618783
16regulation of mitotic spindle organization (GO:0060236)4.67254593
17meiotic chromosome segregation (GO:0045132)4.58899223
18nuclear pore organization (GO:0006999)4.52243778
19nuclear pore complex assembly (GO:0051292)4.49839230
20spindle checkpoint (GO:0031577)4.44558124
21mitotic nuclear envelope disassembly (GO:0007077)4.39446120
22DNA replication-independent nucleosome assembly (GO:0006336)4.38560780
23DNA replication-independent nucleosome organization (GO:0034724)4.38560780
24positive regulation of chromosome segregation (GO:0051984)4.35231669
25regulation of chromosome segregation (GO:0051983)4.25881258
26histone exchange (GO:0043486)4.19760147
27protein localization to chromosome (GO:0034502)4.19251743
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.17947283
29DNA unwinding involved in DNA replication (GO:0006268)4.15336517
30positive regulation of mitotic sister chromatid separation (GO:1901970)4.13032362
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.13032362
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.13032362
33microtubule depolymerization (GO:0007019)4.12953950
34chromosome segregation (GO:0007059)4.12929193
35spindle assembly checkpoint (GO:0071173)4.12228402
36nuclear envelope disassembly (GO:0051081)4.08984070
37membrane disassembly (GO:0030397)4.08984070
38negative regulation of chromosome segregation (GO:0051985)4.07218662
39DNA replication checkpoint (GO:0000076)4.06627344
40negative regulation of mitotic sister chromatid separation (GO:2000816)4.04409722
41negative regulation of mitotic sister chromatid segregation (GO:0033048)4.04409722
42negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.04409722
43negative regulation of sister chromatid segregation (GO:0033046)4.04409722
44regulation of mitotic metaphase/anaphase transition (GO:0030071)4.03038219
45mitotic spindle checkpoint (GO:0071174)3.99850427
46mitotic spindle assembly checkpoint (GO:0007094)3.98358649
47DNA strand elongation involved in DNA replication (GO:0006271)3.98108973
48regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.97961042
49DNA replication initiation (GO:0006270)3.97940063
50negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.97798920
51DNA replication-dependent nucleosome assembly (GO:0006335)3.93258626
52DNA replication-dependent nucleosome organization (GO:0034723)3.93258626
53regulation of mitotic sister chromatid separation (GO:0010965)3.85762813
54regulation of mitotic sister chromatid segregation (GO:0033047)3.85762813
55regulation of sister chromatid segregation (GO:0033045)3.85762813
56mitotic recombination (GO:0006312)3.84947177
57DNA strand elongation (GO:0022616)3.80618092
58telomere maintenance via semi-conservative replication (GO:0032201)3.80242566
59chromosome condensation (GO:0030261)3.75695696
60telomere maintenance via recombination (GO:0000722)3.69532795
61establishment of integrated proviral latency (GO:0075713)3.66335936
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65837530
63protein K6-linked ubiquitination (GO:0085020)3.64598239
64mitotic cytokinesis (GO:0000281)3.59856823
65regulation of centrosome cycle (GO:0046605)3.55987890
66regulation of sister chromatid cohesion (GO:0007063)3.55932022
67mitotic sister chromatid cohesion (GO:0007064)3.53292247
68chromatin assembly or disassembly (GO:0006333)3.51638760
69pore complex assembly (GO:0046931)3.51433450
70DNA topological change (GO:0006265)3.50741774
71regulation of translational fidelity (GO:0006450)3.41122128
72DNA packaging (GO:0006323)3.37807715
73ATP-dependent chromatin remodeling (GO:0043044)3.33921771
74histone-serine phosphorylation (GO:0035404)3.32904453
75establishment of mitotic spindle localization (GO:0040001)3.28477043
76telomere maintenance via telomere lengthening (GO:0010833)3.27763009
77regulation of exit from mitosis (GO:0007096)3.26622837
78nucleobase biosynthetic process (GO:0046112)3.21176696
79nuclear envelope organization (GO:0006998)3.20037240
80spindle assembly involved in mitosis (GO:0090307)3.19679925
81protein complex localization (GO:0031503)3.19390623
82regulation of DNA endoreduplication (GO:0032875)3.17621439
83mitotic spindle organization (GO:0007052)3.17320411
84mitotic cell cycle (GO:0000278)3.16972441
85negative regulation of mitosis (GO:0045839)3.16828499
86spindle organization (GO:0007051)3.16624716
87regulation of centriole replication (GO:0046599)3.15908729
88regulation of centrosome duplication (GO:0010824)3.12096223
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.11306975
90formation of translation preinitiation complex (GO:0001731)3.10718412
91non-recombinational repair (GO:0000726)3.09688772
92double-strand break repair via nonhomologous end joining (GO:0006303)3.09688772
93DNA geometric change (GO:0032392)3.09246518
94DNA conformation change (GO:0071103)3.08212180
95heterochromatin organization (GO:0070828)3.08024949
96DNA duplex unwinding (GO:0032508)3.07119331
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.06657717
98purine nucleobase biosynthetic process (GO:0009113)3.05342979
99regulation of telomere maintenance via telomerase (GO:0032210)2.97680165
100cytoskeleton-dependent cytokinesis (GO:0061640)2.96039896
101mitotic G2/M transition checkpoint (GO:0044818)2.95565142
102chromosome organization (GO:0051276)2.95026496
103mitotic nuclear division (GO:0007067)2.94964286
104resolution of meiotic recombination intermediates (GO:0000712)2.94666558
105nucleobase-containing small molecule interconversion (GO:0015949)2.93667040
106maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92506862
107DNA ligation (GO:0006266)2.89300297
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88866045
109ventricular cardiac muscle cell development (GO:0055015)2.88332511
110mitotic cell cycle checkpoint (GO:0007093)2.86217891
111DNA synthesis involved in DNA repair (GO:0000731)2.85912709
112maturation of SSU-rRNA (GO:0030490)2.85624883
113regulation of histone H3-K9 methylation (GO:0051570)2.85277896
114IMP biosynthetic process (GO:0006188)2.84415531
115negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.84051459
116histone phosphorylation (GO:0016572)2.83772417
117negative regulation of DNA-dependent DNA replication (GO:2000104)2.83614263
118cellular protein complex localization (GO:0034629)2.83271613
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83119049
120telomere maintenance (GO:0000723)2.82476818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.87615555
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.75077151
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.96857274
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.64520440
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.56495465
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.21671276
7AR_21909140_ChIP-Seq_LNCAP_Human3.05375856
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88875986
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72734876
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62904373
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50684474
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.44863919
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44145027
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.40238271
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34398307
16* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33185042
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25599337
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23937489
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.16342423
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.13555290
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.09692521
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08099560
23XRN2_22483619_ChIP-Seq_HELA_Human2.06705779
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00960472
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97776578
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94862844
27VDR_23849224_ChIP-Seq_CD4+_Human1.88041936
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86622676
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78873910
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77478082
31FOXP3_21729870_ChIP-Seq_TREG_Human1.70651639
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69902019
33DCP1A_22483619_ChIP-Seq_HELA_Human1.67065517
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67040901
35ELK1_19687146_ChIP-ChIP_HELA_Human1.66489559
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.64814003
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.63808234
38TTF2_22483619_ChIP-Seq_HELA_Human1.60558395
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56304099
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56129763
41CIITA_25753668_ChIP-Seq_RAJI_Human1.48563498
42GABP_19822575_ChIP-Seq_HepG2_Human1.47607604
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42164541
44KDM5A_27292631_Chip-Seq_BREAST_Human1.40381385
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37427737
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37344983
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36989783
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35985893
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34872269
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33713440
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30436637
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29907228
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28235373
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27994204
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27679537
56ZNF263_19887448_ChIP-Seq_K562_Human1.26523275
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23462177
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22045489
59* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20712173
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20428560
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17843906
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16702214
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16665467
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15532446
65MYC_22102868_ChIP-Seq_BL_Human1.14921095
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13550201
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07547044
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03699504
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.03187798
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00103124
71NANOG_21062744_ChIP-ChIP_HESCs_Human0.99569941
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98437789
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98134405
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97647935
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96421486
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94983241
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94571894
78CHD1_26751641_Chip-Seq_LNCaP_Human0.94547481
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93851901
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92409542
81MYC_18940864_ChIP-ChIP_HL60_Human0.90622996
82TFEB_21752829_ChIP-Seq_HELA_Human0.90033161
83SRF_21415370_ChIP-Seq_HL-1_Mouse0.89620629
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88660653
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88088368
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87534377
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87473251
88PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87058415
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86707807
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85684708
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83767607
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82116264
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.80142489
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79826594
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79623860
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79446786
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77696426
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.77182948
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75846594
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75500959
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74985942
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74653712
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74313406
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.73785849
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72725027
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72200515
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71158105
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70352102
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70295341
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69917086
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69385422
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69273343
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67908453
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67695580
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.64978016
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63790823
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.63536312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52115946
2MP0003111_abnormal_nucleus_morphology5.01551892
3MP0010094_abnormal_chromosome_stability4.88451810
4MP0003077_abnormal_cell_cycle4.27547949
5MP0004957_abnormal_blastocyst_morpholog4.03805795
6MP0008057_abnormal_DNA_replication3.80025952
7MP0008058_abnormal_DNA_repair3.15475373
8MP0008007_abnormal_cellular_replicative3.03638823
9MP0008932_abnormal_embryonic_tissue2.67472183
10MP0003123_paternal_imprinting2.39481159
11MP0010307_abnormal_tumor_latency2.33173892
12MP0008877_abnormal_DNA_methylation2.30988506
13MP0001730_embryonic_growth_arrest2.28205923
14MP0000350_abnormal_cell_proliferation2.27960701
15MP0002877_abnormal_melanocyte_morpholog2.25885355
16MP0003718_maternal_effect2.02428542
17MP0009697_abnormal_copulation1.92418286
18MP0003786_premature_aging1.88598657
19MP0002396_abnormal_hematopoietic_system1.87222002
20MP0001672_abnormal_embryogenesis/_devel1.83288660
21MP0005380_embryogenesis_phenotype1.83288660
22MP0001697_abnormal_embryo_size1.75753931
23MP0010352_gastrointestinal_tract_polyps1.75490320
24MP0003121_genomic_imprinting1.66170536
25MP0002085_abnormal_embryonic_tissue1.65513470
26MP0010030_abnormal_orbit_morphology1.63023217
27MP0005076_abnormal_cell_differentiation1.61389803
28MP0003984_embryonic_growth_retardation1.57704330
29MP0002088_abnormal_embryonic_growth/wei1.53646667
30MP0002080_prenatal_lethality1.52181020
31MP0002084_abnormal_developmental_patter1.48552802
32MP0004233_abnormal_muscle_weight1.45647045
33MP0004808_abnormal_hematopoietic_stem1.45121277
34MP0002210_abnormal_sex_determination1.44106069
35MP0002086_abnormal_extraembryonic_tissu1.41672796
36MP0005623_abnormal_meninges_morphology1.40966530
37MP0004197_abnormal_fetal_growth/weight/1.40735673
38MP0000490_abnormal_crypts_of1.36289502
39MP0000313_abnormal_cell_death1.32893303
40MP0001346_abnormal_lacrimal_gland1.32776474
41MP0003567_abnormal_fetal_cardiomyocyte1.32183269
42MP0003937_abnormal_limbs/digits/tail_de1.30907962
43MP0003950_abnormal_plasma_membrane1.27145130
44MP0002019_abnormal_tumor_incidence1.24372933
45MP0001929_abnormal_gametogenesis1.22461725
46MP0001145_abnormal_male_reproductive1.20412964
47MP0001293_anophthalmia1.18649928
48MP0009053_abnormal_anal_canal1.16720602
49MP0003315_abnormal_perineum_morphology1.16343968
50MP0004185_abnormal_adipocyte_glucose1.16259925
51MP0003705_abnormal_hypodermis_morpholog1.13181709
52MP0003941_abnormal_skin_development1.12985297
53MP0003890_abnormal_embryonic-extraembry1.12795032
54MP0000653_abnormal_sex_gland1.10573559
55MP0010234_abnormal_vibrissa_follicle1.08827691
56MP0000537_abnormal_urethra_morphology1.06658497
57MP0001119_abnormal_female_reproductive1.04307742
58MP0000358_abnormal_cell_content/1.03783071
59MP0002009_preneoplasia1.03295998
60MP0005397_hematopoietic_system_phenotyp0.95015123
61MP0001545_abnormal_hematopoietic_system0.95015123
62MP0003385_abnormal_body_wall0.93202128
63MP0006054_spinal_hemorrhage0.91281757
64MP0005501_abnormal_skin_physiology0.90467061
65MP0002111_abnormal_tail_morphology0.90346206
66MP0006292_abnormal_olfactory_placode0.90093397
67MP0000428_abnormal_craniofacial_morphol0.87462787
68MP0002234_abnormal_pharynx_morphology0.86267155
69MP0009278_abnormal_bone_marrow0.85180738
70MP0004147_increased_porphyrin_level0.83704474
71MP0000703_abnormal_thymus_morphology0.82716549
72MP0001661_extended_life_span0.82154722
73MP0001286_abnormal_eye_development0.82127555
74MP0005621_abnormal_cell_physiology0.80375159
75MP0003115_abnormal_respiratory_system0.79971406
76MP0002092_abnormal_eye_morphology0.79730872
77MP0009672_abnormal_birth_weight0.79654060
78MP0000432_abnormal_head_morphology0.79342816
79MP0003566_abnormal_cell_adhesion0.78676999
80MP0001915_intracranial_hemorrhage0.78030105
81MP0005384_cellular_phenotype0.76964685
82MP0002938_white_spotting0.76523416
83MP0001727_abnormal_embryo_implantation0.76077665
84MP0003755_abnormal_palate_morphology0.76075308
85MP0002233_abnormal_nose_morphology0.75632523
86MP0005389_reproductive_system_phenotype0.75530401
87MP0009703_decreased_birth_body0.75364797
88MP0005023_abnormal_wound_healing0.75035806
89MP0005171_absent_coat_pigmentation0.74879208
90MP0005257_abnormal_intraocular_pressure0.74773514
91MP0000534_abnormal_ureter_morphology0.74437712
92MP0009333_abnormal_splenocyte_physiolog0.74291320
93MP0000762_abnormal_tongue_morphology0.73636628
94MP0002249_abnormal_larynx_morphology0.73328583
95MP0002102_abnormal_ear_morphology0.72506711
96MP0005408_hypopigmentation0.72445706
97MP0000733_abnormal_muscle_development0.72338184
98MP0006035_abnormal_mitochondrial_morpho0.72237856
99MP0003699_abnormal_female_reproductive0.71712213
100MP0003935_abnormal_craniofacial_develop0.70748373
101MP0001849_ear_inflammation0.69171507
102MP0005187_abnormal_penis_morphology0.69070226
103MP0002160_abnormal_reproductive_system0.68886389
104MP0003943_abnormal_hepatobiliary_system0.68758780
105MP0002653_abnormal_ependyma_morphology0.67177265
106MP0009250_abnormal_appendicular_skeleto0.67022207
107MP0002932_abnormal_joint_morphology0.66285378
108MP0002697_abnormal_eye_size0.66233298
109MP0003119_abnormal_digestive_system0.66223270
110MP0000569_abnormal_digit_pigmentation0.65887897
111MP0003938_abnormal_ear_development0.65801144
112MP0000383_abnormal_hair_follicle0.65031916
113MP0004272_abnormal_basement_membrane0.64928388
114MP0000858_altered_metastatic_potential0.62777422
115MP0000049_abnormal_middle_ear0.62655319
116MP0002398_abnormal_bone_marrow0.62522034
117MP0002282_abnormal_trachea_morphology0.62512201
118MP0002722_abnormal_immune_system0.62296911
119MP0005395_other_phenotype0.62293375
120MP0002161_abnormal_fertility/fecundity0.62104895
121MP0003698_abnormal_male_reproductive0.61938293
122MP0002269_muscular_atrophy0.60915742
123MP0003656_abnormal_erythrocyte_physiolo0.60330046
124MP0003787_abnormal_imprinting0.60247033
125MP0000566_synostosis0.58437798
126MP0003861_abnormal_nervous_system0.58048587
127MP0001919_abnormal_reproductive_system0.57252676
128MP0002114_abnormal_axial_skeleton0.56930935
129MP0002925_abnormal_cardiovascular_devel0.56214520
130MP0003942_abnormal_urinary_system0.55123752
131MP0000689_abnormal_spleen_morphology0.54334775

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.08775610
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.91957513
3Birth length less than 3rd percentile (HP:0003561)4.15812144
4Abnormality of chromosome stability (HP:0003220)3.79065602
5Patellar aplasia (HP:0006443)3.73909383
6Meckel diverticulum (HP:0002245)3.62751487
7Impulsivity (HP:0100710)3.59936351
8Aplasia/Hypoplasia of the patella (HP:0006498)3.50158217
9Abnormality of the preputium (HP:0100587)3.45730662
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.44234870
11Breast hypoplasia (HP:0003187)3.42769931
12Abnormality of the ileum (HP:0001549)3.41372974
13Duodenal stenosis (HP:0100867)3.39643062
14Small intestinal stenosis (HP:0012848)3.39643062
15Cortical dysplasia (HP:0002539)3.28066043
16Carpal bone hypoplasia (HP:0001498)3.25113252
17Selective tooth agenesis (HP:0001592)3.05175582
18Absent radius (HP:0003974)3.00827899
19Abnormality of the labia minora (HP:0012880)2.94593136
20Reticulocytopenia (HP:0001896)2.94359148
21Abnormal lung lobation (HP:0002101)2.91710738
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89644620
23Increased nuchal translucency (HP:0010880)2.88789659
24Myelodysplasia (HP:0002863)2.87448879
25Nephroblastoma (Wilms tumor) (HP:0002667)2.86025438
26Ectopic kidney (HP:0000086)2.82362168
27Aplasia involving forearm bones (HP:0009822)2.81343601
28Absent forearm bone (HP:0003953)2.81343601
29Abnormality of the duodenum (HP:0002246)2.77422093
30Colon cancer (HP:0003003)2.76788574
31Medulloblastoma (HP:0002885)2.73966953
32Sloping forehead (HP:0000340)2.73910852
33Embryonal renal neoplasm (HP:0011794)2.68411472
34Volvulus (HP:0002580)2.66664077
35Abnormality of the anterior horn cell (HP:0006802)2.63036459
36Degeneration of anterior horn cells (HP:0002398)2.63036459
37Facial hemangioma (HP:0000329)2.49678854
38Short 4th metacarpal (HP:0010044)2.47939501
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47939501
4011 pairs of ribs (HP:0000878)2.45308982
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42310615
42Abnormality of the carotid arteries (HP:0005344)2.41552403
43Ependymoma (HP:0002888)2.40178063
44Oral leukoplakia (HP:0002745)2.38611137
45Supernumerary spleens (HP:0009799)2.37252550
46Bone marrow hypocellularity (HP:0005528)2.35169716
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31998242
48High anterior hairline (HP:0009890)2.31243161
49Rough bone trabeculation (HP:0100670)2.30491449
50Deviation of the thumb (HP:0009603)2.30343461
51Short thumb (HP:0009778)2.29205929
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.27962608
53Duplicated collecting system (HP:0000081)2.27891479
54Cafe-au-lait spot (HP:0000957)2.25743726
55Proximal placement of thumb (HP:0009623)2.25705303
56Absent thumb (HP:0009777)2.25314606
57Horseshoe kidney (HP:0000085)2.21762808
58Rhabdomyosarcoma (HP:0002859)2.19681828
59Tracheoesophageal fistula (HP:0002575)2.16559877
60Hyperacusis (HP:0010780)2.15729144
61Insomnia (HP:0100785)2.15377934
62Neoplasm of the pancreas (HP:0002894)2.14365129
63Duplication of thumb phalanx (HP:0009942)2.13785721
64Clubbing of toes (HP:0100760)2.11692806
65Triphalangeal thumb (HP:0001199)2.10381561
66Abnormality of the fetal cardiovascular system (HP:0010948)2.10157205
67Abnormal umbilical cord blood vessels (HP:0011403)2.10157205
68Single umbilical artery (HP:0001195)2.10157205
69Abnormal number of incisors (HP:0011064)2.08914110
70Atresia of the external auditory canal (HP:0000413)2.04394179
71Abnormality of the umbilical cord (HP:0010881)2.04131473
72High pitched voice (HP:0001620)2.04031591
73Abnormality of cochlea (HP:0000375)2.03036974
74Ankle contracture (HP:0006466)2.01436245
75Abnormality of the proximal phalanges of the hand (HP:0009834)2.00731614
76Oligodactyly (HP:0012165)2.00266057
77Abnormality of the renal collecting system (HP:0004742)1.99498865
78Broad distal phalanx of finger (HP:0009836)1.99116425
79Agnosia (HP:0010524)1.98889083
80Abnormal gallbladder physiology (HP:0012438)1.97356997
81Cholecystitis (HP:0001082)1.97356997
82Oligodactyly (hands) (HP:0001180)1.96165854
83Abnormality of the phalanges of the hallux (HP:0010057)1.95479523
84Abnormality of chromosome segregation (HP:0002916)1.94081951
85Missing ribs (HP:0000921)1.93242104
86Premature graying of hair (HP:0002216)1.91090802
87Progressive muscle weakness (HP:0003323)1.89897355
88Abnormality of reticulocytes (HP:0004312)1.89673663
89Prominent nose (HP:0000448)1.88521619
90Abnormality of the calcaneus (HP:0008364)1.87521985
91Wrist flexion contracture (HP:0001239)1.86881892
92Microvesicular hepatic steatosis (HP:0001414)1.86804104
93Abnormality of glycolysis (HP:0004366)1.86178031
94Aplasia/Hypoplasia of the earlobes (HP:0009906)1.85728154
95Neoplasm of the colon (HP:0100273)1.85635375
96Embryonal neoplasm (HP:0002898)1.85592337
97Septate vagina (HP:0001153)1.84046111
98Small epiphyses (HP:0010585)1.82782289
99Hypoplastic pelvis (HP:0008839)1.81367928
100Glioma (HP:0009733)1.80893928
101Squamous cell carcinoma (HP:0002860)1.80481602
102Ulnar bowing (HP:0003031)1.79930922
103Ureteral duplication (HP:0000073)1.79586436
104Short middle phalanx of the 5th finger (HP:0004220)1.77578706
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77535937
106Absent epiphyses (HP:0010577)1.77535937
107Arteriovenous malformation (HP:0100026)1.76250537
108Overriding aorta (HP:0002623)1.75388850
109Heterotopia (HP:0002282)1.75000650
110Aplasia/hypoplasia of the humerus (HP:0006507)1.74936099
111Deep philtrum (HP:0002002)1.74504970
112Choanal atresia (HP:0000453)1.74358553
113Abnormality of DNA repair (HP:0003254)1.72720209
114Overlapping toe (HP:0001845)1.72073361
115Abnormality of the astrocytes (HP:0100707)1.71687715
116Astrocytoma (HP:0009592)1.71687715
117Slender long bone (HP:0003100)1.71016533
118Cellular immunodeficiency (HP:0005374)1.70008529
119Abnormal trabecular bone morphology (HP:0100671)1.69984660
120Microglossia (HP:0000171)1.69837645
121Entropion (HP:0000621)1.68860327
122Renal duplication (HP:0000075)1.68670001
123Ankyloglossia (HP:0010296)1.67786029
124Flat capital femoral epiphysis (HP:0003370)1.67744676
125Abnormality of cells of the erythroid lineage (HP:0012130)1.67350604
126Poikiloderma (HP:0001029)1.66789732
127Sandal gap (HP:0001852)1.66702559
128Capillary hemangiomas (HP:0005306)1.64621134
129Aplastic anemia (HP:0001915)1.64497711
130Morphological abnormality of the inner ear (HP:0011390)1.62873697
131Orthostatic hypotension (HP:0001278)1.62717528
132Multiple enchondromatosis (HP:0005701)1.62625846
133Ovarian neoplasm (HP:0100615)1.62436656
134Premature ovarian failure (HP:0008209)1.61501437
135Facial cleft (HP:0002006)1.55867779
136Progressive external ophthalmoplegia (HP:0000590)1.55544866
137Obsessive-compulsive behavior (HP:0000722)1.55211943
138Elfin facies (HP:0004428)1.54000779
139Flared metaphyses (HP:0003015)1.53056922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.54089940
2WEE14.48796490
3CDC74.36773179
4NEK23.64882765
5TTK3.34030996
6BRSK23.20637018
7NEK12.82335184
8PLK42.57684076
9* PLK12.44588689
10SRPK12.43249010
11EIF2AK12.28566972
12BRSK12.24292616
13AURKB2.16684576
14PLK32.06203035
15CCNB11.95177589
16CHEK21.81144724
17MKNK11.80561187
18STK101.76182004
19ACVR1B1.65419342
20CDK121.63564641
21ATR1.62228052
22STK41.57008337
23MAP3K81.53369177
24ZAK1.51985934
25SMG11.46640710
26CDK71.45687932
27AURKA1.44789344
28VRK11.44255506
29MST1R1.43922569
30MKNK21.41422878
31RPS6KA41.40882394
32TSSK61.39159745
33VRK21.38074054
34STK31.37820213
35TRIB31.37248240
36CHEK11.37177825
37MELK1.34482261
38EEF2K1.30200425
39CDK41.25150541
40TLK11.23482489
41PASK1.21956307
42RPS6KB21.21255792
43DYRK31.20207138
44ICK1.19819851
45LATS11.19389602
46EIF2AK31.13699690
47TESK21.13146915
48EPHA21.12599012
49IRAK31.02362905
50ATM1.01835441
51STK38L0.99781753
52EIF2AK20.99244484
53MET0.96524655
54* CDK20.85098640
55CDK60.82115311
56* CDK10.80892983
57STK160.80146026
58TAF10.78667483
59BRD40.77873941
60PAK40.77374242
61PDK20.75885477
62NME20.75103091
63ERBB40.72187010
64PBK0.70791108
65BRAF0.66120893
66CLK10.65716137
67LATS20.64821618
68PAK10.62720593
69TGFBR10.62620575
70MAP3K100.58697988
71PIM10.58585952
72CDK80.56429662
73NUAK10.55672710
74CDK11A0.51598554
75MARK30.50919822
76TESK10.50118155
77KSR20.49610180
78NME10.49582973
79SCYL20.49481913
80RAF10.49311890
81CSNK2A10.49080421
82PTK20.45493213
83RPS6KA50.45390728
84LRRK20.44571659
85PDGFRA0.44234700
86KSR10.43174377
87CDK140.42511281
88PRKCI0.41945897
89PDK40.41756187
90PDK30.41756187
91CSNK2A20.40269354
92TTN0.39939389
93CAMK1G0.39161904
94MTOR0.38408207
95PKN20.35906845
96PRKDC0.33603306
97ILK0.32827470
98ALK0.31438924
99AKT20.31260332
100NEK90.30626563
101TRPM70.29500852
102MAPK140.28640887
103SIK10.28193769
104AKT30.27040338
105PAK20.25081558
106MAP3K90.24967822
107MAPK110.24607985
108CDK90.24017615
109STK240.23851184
110PNCK0.23424408
111AKT10.23410212
112CSNK1D0.19685458
113CSNK1E0.19576331
114ERBB30.18711401
115GSK3B0.18421259
116CHUK0.18057627
117MAPKAPK20.17606014
118ERBB20.17549727
119MAPK10.16198099
120CDK30.13239610
121YES10.12583332
122CDK150.12486812
123CDK180.12103664

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61985336
2Mismatch repair_Homo sapiens_hsa034304.08185724
3Cell cycle_Homo sapiens_hsa041103.73619291
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47249907
5Homologous recombination_Homo sapiens_hsa034403.44281600
6RNA transport_Homo sapiens_hsa030133.22001675
7Spliceosome_Homo sapiens_hsa030403.15417483
8Base excision repair_Homo sapiens_hsa034103.03345076
9Fanconi anemia pathway_Homo sapiens_hsa034602.94656537
10Nucleotide excision repair_Homo sapiens_hsa034202.86928552
11RNA polymerase_Homo sapiens_hsa030202.71855320
12Non-homologous end-joining_Homo sapiens_hsa034502.36744600
13One carbon pool by folate_Homo sapiens_hsa006702.29834452
14p53 signaling pathway_Homo sapiens_hsa041152.19265317
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16784662
16Proteasome_Homo sapiens_hsa030502.15717574
17Basal transcription factors_Homo sapiens_hsa030222.14912886
18Pyrimidine metabolism_Homo sapiens_hsa002402.09779636
19RNA degradation_Homo sapiens_hsa030182.04115056
20Ribosome_Homo sapiens_hsa030102.00613861
21mRNA surveillance pathway_Homo sapiens_hsa030151.95759040
22Systemic lupus erythematosus_Homo sapiens_hsa053221.83930548
23Oocyte meiosis_Homo sapiens_hsa041141.62983022
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56219056
25Vitamin B6 metabolism_Homo sapiens_hsa007501.54327764
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53249045
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31775951
28Viral carcinogenesis_Homo sapiens_hsa052031.29304166
29Epstein-Barr virus infection_Homo sapiens_hsa051691.23718263
30MicroRNAs in cancer_Homo sapiens_hsa052061.18877302
31Purine metabolism_Homo sapiens_hsa002301.14266811
32Pyruvate metabolism_Homo sapiens_hsa006201.09568916
33Herpes simplex infection_Homo sapiens_hsa051681.00690717
34HTLV-I infection_Homo sapiens_hsa051660.98818585
35Small cell lung cancer_Homo sapiens_hsa052220.98463999
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93818715
37Sulfur relay system_Homo sapiens_hsa041220.87809824
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83886566
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83344267
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75896320
41Antigen processing and presentation_Homo sapiens_hsa046120.75758595
42Hippo signaling pathway_Homo sapiens_hsa043900.74338038
43Alcoholism_Homo sapiens_hsa050340.73168851
44TGF-beta signaling pathway_Homo sapiens_hsa043500.72313669
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69795182
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67336657
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66000871
48Pentose phosphate pathway_Homo sapiens_hsa000300.64921037
49Basal cell carcinoma_Homo sapiens_hsa052170.64265340
50Thyroid cancer_Homo sapiens_hsa052160.61862590
51Steroid biosynthesis_Homo sapiens_hsa001000.60307916
52Colorectal cancer_Homo sapiens_hsa052100.60202934
53Adherens junction_Homo sapiens_hsa045200.58358151
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57335548
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56931918
56Apoptosis_Homo sapiens_hsa042100.55921064
57Fructose and mannose metabolism_Homo sapiens_hsa000510.54099221
58Selenocompound metabolism_Homo sapiens_hsa004500.52380841
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50842256
60Hepatitis B_Homo sapiens_hsa051610.49123795
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47960944
62Chronic myeloid leukemia_Homo sapiens_hsa052200.47721353
63Biosynthesis of amino acids_Homo sapiens_hsa012300.47140922
64Notch signaling pathway_Homo sapiens_hsa043300.46666924
65Glioma_Homo sapiens_hsa052140.46173043
66Protein export_Homo sapiens_hsa030600.45185624
67Legionellosis_Homo sapiens_hsa051340.44774837
68Hedgehog signaling pathway_Homo sapiens_hsa043400.44183012
69Huntingtons disease_Homo sapiens_hsa050160.43268893
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.43142820
71Bladder cancer_Homo sapiens_hsa052190.42556426
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.41426793
73FoxO signaling pathway_Homo sapiens_hsa040680.40547696
74Pathways in cancer_Homo sapiens_hsa052000.40497730
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38768421
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38467770
77Viral myocarditis_Homo sapiens_hsa054160.38223692
78Prostate cancer_Homo sapiens_hsa052150.37819363
79Influenza A_Homo sapiens_hsa051640.37089762
80Shigellosis_Homo sapiens_hsa051310.36588909
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36433959
82Pancreatic cancer_Homo sapiens_hsa052120.35361517
83Measles_Homo sapiens_hsa051620.35183612
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.35164989
85Fatty acid elongation_Homo sapiens_hsa000620.34970917
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33665766
87Galactose metabolism_Homo sapiens_hsa000520.32717705
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31107059
89Folate biosynthesis_Homo sapiens_hsa007900.30004996
90Lysine degradation_Homo sapiens_hsa003100.29365453
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28885070
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28842512
93HIF-1 signaling pathway_Homo sapiens_hsa040660.27974115
94Gap junction_Homo sapiens_hsa045400.27802209
95Proteoglycans in cancer_Homo sapiens_hsa052050.27040929
96Renal cell carcinoma_Homo sapiens_hsa052110.26557211
97AMPK signaling pathway_Homo sapiens_hsa041520.24667324
98Glutathione metabolism_Homo sapiens_hsa004800.24609770
99Melanoma_Homo sapiens_hsa052180.24552192
100ErbB signaling pathway_Homo sapiens_hsa040120.24105790
101Tight junction_Homo sapiens_hsa045300.24014748
102mTOR signaling pathway_Homo sapiens_hsa041500.23593286
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22817720
104Hematopoietic cell lineage_Homo sapiens_hsa046400.22685127
105Wnt signaling pathway_Homo sapiens_hsa043100.21943059
106Primary immunodeficiency_Homo sapiens_hsa053400.21939113
107ECM-receptor interaction_Homo sapiens_hsa045120.21819023
108Non-small cell lung cancer_Homo sapiens_hsa052230.21312138
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20804517
110Endometrial cancer_Homo sapiens_hsa052130.19652468
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.19508768
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19234962
113Metabolic pathways_Homo sapiens_hsa011000.18043247
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17860340
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.17267926
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16845932
117N-Glycan biosynthesis_Homo sapiens_hsa005100.16414109
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15177652
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.15042852
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15025939
121Focal adhesion_Homo sapiens_hsa045100.13098674
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.11952956
123Renin-angiotensin system_Homo sapiens_hsa046140.11827930
124Carbon metabolism_Homo sapiens_hsa012000.07533484
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06246640
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06126101

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