PRAMEF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.15010336
2nuclear pore organization (GO:0006999)3.89535868
3mitotic chromosome condensation (GO:0007076)3.82814460
4protein localization to kinetochore (GO:0034501)3.43481185
5pore complex assembly (GO:0046931)3.34505332
6positive regulation of gamma-delta T cell activation (GO:0046645)3.31374840
7piRNA metabolic process (GO:0034587)3.28867056
8protein localization to chromosome, centromeric region (GO:0071459)3.15151309
9mitotic metaphase plate congression (GO:0007080)3.08473638
10mitotic nuclear envelope disassembly (GO:0007077)3.02686302
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98263070
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98263070
13negative regulation of histone methylation (GO:0031061)2.92501473
14nuclear envelope disassembly (GO:0051081)2.92055362
15membrane disassembly (GO:0030397)2.92055362
16NIK/NF-kappaB signaling (GO:0038061)2.87015021
17regulation of spindle organization (GO:0090224)2.84490008
18mitotic sister chromatid cohesion (GO:0007064)2.84395299
19attachment of spindle microtubules to kinetochore (GO:0008608)2.78816934
20protein K6-linked ubiquitination (GO:0085020)2.78377577
21antigen processing and presentation of endogenous antigen (GO:0019883)2.74601116
22monoubiquitinated protein deubiquitination (GO:0035520)2.73431822
23nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.69207993
24regulation of mitotic spindle organization (GO:0060236)2.67484012
25regulation of gamma-delta T cell activation (GO:0046643)2.66368946
26metaphase plate congression (GO:0051310)2.64317656
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63492919
28regulation of gamma-delta T cell differentiation (GO:0045586)2.62652455
29gene silencing by RNA (GO:0031047)2.62308290
30natural killer cell mediated immunity (GO:0002228)2.59307595
31natural killer cell mediated cytotoxicity (GO:0042267)2.59307595
32transport of virus (GO:0046794)2.59185806
33intracellular transport of virus (GO:0075733)2.59185806
34multi-organism transport (GO:0044766)2.59185806
35multi-organism localization (GO:1902579)2.59185806
36multi-organism intracellular transport (GO:1902583)2.59185806
37establishment of chromosome localization (GO:0051303)2.57414534
38meiotic chromosome segregation (GO:0045132)2.56453122
39Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54981417
40regulation of histone H3-K9 methylation (GO:0051570)2.54807358
41* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.53954692
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53416349
43chaperone mediated protein folding requiring cofactor (GO:0051085)2.52558891
44immunoglobulin mediated immune response (GO:0016064)2.50444964
45regulation of RIG-I signaling pathway (GO:0039535)2.50343539
46regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.48486623
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47213825
48histone H2A monoubiquitination (GO:0035518)2.46869371
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.45868863
50negative regulation of meiosis (GO:0045835)2.45777351
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44657987
52histone mRNA catabolic process (GO:0071044)2.39156517
53folic acid-containing compound biosynthetic process (GO:0009396)2.38829275
54positive regulation of protein import into nucleus, translocation (GO:0033160)2.38644777
55B cell mediated immunity (GO:0019724)2.37042733
56Golgi transport vesicle coating (GO:0048200)2.34819314
57COPI coating of Golgi vesicle (GO:0048205)2.34819314
58mismatch repair (GO:0006298)2.32359692
59spindle checkpoint (GO:0031577)2.32262416
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.31544437
61chromatin remodeling at centromere (GO:0031055)2.30776243
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30389078
63protein localization to chromosome (GO:0034502)2.30069073
64sister chromatid cohesion (GO:0007062)2.29546600
65kinetochore organization (GO:0051383)2.29345010
66DNA methylation involved in gamete generation (GO:0043046)2.29320248
67chromosome segregation (GO:0007059)2.28829093
68CENP-A containing nucleosome assembly (GO:0034080)2.28760044
69formation of translation preinitiation complex (GO:0001731)2.27241464
70positive regulation of interferon-beta production (GO:0032728)2.26375735
71regulation of translation in response to stress (GO:0043555)2.25858705
72negative T cell selection (GO:0043383)2.24938711
73DNA replication initiation (GO:0006270)2.24311829
74nucleus organization (GO:0006997)2.24001341
75DNA replication checkpoint (GO:0000076)2.22884624
76regulation of chromosome segregation (GO:0051983)2.22460901
77maturation of 5.8S rRNA (GO:0000460)2.22344598
78male meiosis (GO:0007140)2.22078249
79DNA duplex unwinding (GO:0032508)2.21677671
80DNA geometric change (GO:0032392)2.21623198
81mitotic sister chromatid segregation (GO:0000070)2.20977161
82regulation of response to interferon-gamma (GO:0060330)2.20548869
83regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.20302521
84meiotic nuclear division (GO:0007126)2.20190509
85DNA replication-dependent nucleosome assembly (GO:0006335)2.19601575
86DNA replication-dependent nucleosome organization (GO:0034723)2.19601575
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.19401653
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.19401653
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.19401653
90viral protein processing (GO:0019082)2.18504339
91negative regulation of chromosome segregation (GO:0051985)2.18375761
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.18248105
93negative regulation of sister chromatid segregation (GO:0033046)2.18248105
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.18248105
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.18248105
96regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.18007272
97mitotic spindle checkpoint (GO:0071174)2.17291244
98regulation of telomere maintenance via telomerase (GO:0032210)2.16810162
99snRNA transcription (GO:0009301)2.16755377
100sister chromatid segregation (GO:0000819)2.15554639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.98190304
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.12056299
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.69957592
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53226981
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.88607193
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50593841
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46341937
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45012979
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44199461
10ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.25758173
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09879771
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09455956
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.09404937
14MYC_22102868_ChIP-Seq_BL_Human2.08856187
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.03266489
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.97631344
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93460357
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92134314
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90901827
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88625796
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87348211
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85366037
23MYB_26560356_Chip-Seq_TH2_Human1.83103727
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74361483
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69594118
26VDR_23849224_ChIP-Seq_CD4+_Human1.68526756
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66887510
28ELK1_19687146_ChIP-ChIP_HELA_Human1.66829600
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55707850
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.55296236
31MYB_26560356_Chip-Seq_TH1_Human1.53503833
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53241340
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49811984
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47272014
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47059551
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45679023
37FOXP3_21729870_ChIP-Seq_TREG_Human1.45476465
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.44868804
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.44276072
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43745403
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.43528710
42SPI1_23547873_ChIP-Seq_NB4_Human1.41178482
43XRN2_22483619_ChIP-Seq_HELA_Human1.41014732
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40401944
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39084519
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38284670
47MAF_26560356_Chip-Seq_TH1_Human1.37789613
48AR_21909140_ChIP-Seq_LNCAP_Human1.37469385
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36594702
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35596260
51TFEB_21752829_ChIP-Seq_HELA_Human1.35442518
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33109445
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33042067
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32532103
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31843836
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31569158
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.30928590
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30924153
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27585815
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25798904
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25005521
62UTX_26944678_Chip-Seq_JUKART_Human1.22217563
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20747984
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20312516
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.19788774
66GATA3_27048872_Chip-Seq_THYMUS_Human1.19427999
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18743536
68GABP_19822575_ChIP-Seq_HepG2_Human1.18436243
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17773009
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17572175
71KDM5A_27292631_Chip-Seq_BREAST_Human1.15962419
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14836105
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14817950
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14716274
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14353518
76* RUNX1_22412390_ChIP-Seq_EML_Mouse1.12811761
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11004011
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10807263
79CIITA_25753668_ChIP-Seq_RAJI_Human1.07715894
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06618787
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03795082
82RUNX_20019798_ChIP-Seq_JUKART_Human1.03016205
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.02404603
84TCF7_22412390_ChIP-Seq_EML_Mouse1.01842804
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98107205
86DCP1A_22483619_ChIP-Seq_HELA_Human0.98056741
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97823104
88GATA1_22025678_ChIP-Seq_K562_Human0.95760939
89MAF_26560356_Chip-Seq_TH2_Human0.95552897
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95461222
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94716152
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94690004
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94141005
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94081876
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.93732184
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93248871
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93142806
98GATA3_26560356_Chip-Seq_TH2_Human0.90434113
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90430176
100TTF2_22483619_ChIP-Seq_HELA_Human0.89113517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching2.75185718
2MP0008057_abnormal_DNA_replication2.67169354
3MP0003077_abnormal_cell_cycle2.59931278
4MP0003763_abnormal_thymus_physiology2.54266061
5MP0010352_gastrointestinal_tract_polyps2.39775293
6MP0008007_abnormal_cellular_replicative2.35863481
7MP0002877_abnormal_melanocyte_morpholog2.34219853
8MP0003111_abnormal_nucleus_morphology2.34067717
9MP0010307_abnormal_tumor_latency2.24962468
10MP0010094_abnormal_chromosome_stability2.21614613
11MP0009333_abnormal_splenocyte_physiolog2.11980404
12MP0004957_abnormal_blastocyst_morpholog2.10163839
13MP0001835_abnormal_antigen_presentation2.08162175
14MP0005397_hematopoietic_system_phenotyp2.00325269
15MP0001545_abnormal_hematopoietic_system2.00325269
16MP0005076_abnormal_cell_differentiation1.95710009
17MP0005671_abnormal_response_to1.87676717
18MP0009785_altered_susceptibility_to1.83196380
19MP0001800_abnormal_humoral_immune1.81909043
20MP0005387_immune_system_phenotype1.74689982
21MP0001790_abnormal_immune_system1.74689982
22MP0002398_abnormal_bone_marrow1.71317683
23MP0000685_abnormal_immune_system1.69657351
24MP0002452_abnormal_antigen_presenting1.69389685
25MP0009278_abnormal_bone_marrow1.69151171
26MP0008058_abnormal_DNA_repair1.68510445
27MP0002420_abnormal_adaptive_immunity1.67415476
28MP0008877_abnormal_DNA_methylation1.65211930
29MP0001819_abnormal_immune_cell1.64806462
30MP0000350_abnormal_cell_proliferation1.62502779
31MP0004947_skin_inflammation1.58238441
32MP0002405_respiratory_system_inflammati1.57722465
33MP0002723_abnormal_immune_serum1.55429335
34MP0005000_abnormal_immune_tolerance1.55067717
35MP0004808_abnormal_hematopoietic_stem1.48354015
36MP0000689_abnormal_spleen_morphology1.46045797
37MP0000703_abnormal_thymus_morphology1.45146802
38MP0003786_premature_aging1.44648320
39MP0000716_abnormal_immune_system1.43831505
40MP0002006_tumorigenesis1.42699968
41MP0002722_abnormal_immune_system1.41453661
42MP0010030_abnormal_orbit_morphology1.38193492
43MP0003436_decreased_susceptibility_to1.37954167
44MP0002166_altered_tumor_susceptibility1.37356994
45MP0003448_altered_tumor_morphology1.37072857
46MP0002419_abnormal_innate_immunity1.34829997
47MP0006054_spinal_hemorrhage1.34385454
48MP0001730_embryonic_growth_arrest1.31513805
49MP0010234_abnormal_vibrissa_follicle1.28973563
50MP0002429_abnormal_blood_cell1.28037916
51MP0002019_abnormal_tumor_incidence1.27680410
52MP0005025_abnormal_response_to1.24204472
53MP0003300_gastrointestinal_ulcer1.21515603
54MP0005023_abnormal_wound_healing1.20810519
55MP0005257_abnormal_intraocular_pressure1.20713220
56MP0002148_abnormal_hypersensitivity_rea1.20360507
57MP0000858_altered_metastatic_potential1.19978684
58MP0003724_increased_susceptibility_to1.19513580
59MP0001929_abnormal_gametogenesis1.15577993
60MP0010155_abnormal_intestine_physiology1.15511095
61MP0003705_abnormal_hypodermis_morpholog1.15179911
62MP0003091_abnormal_cell_migration1.13637319
63MP0001851_eye_inflammation1.12730223
64MP0001873_stomach_inflammation1.12294217
65MP0003303_peritoneal_inflammation1.11483642
66MP0008260_abnormal_autophagy1.11272166
67MP0003718_maternal_effect1.10708450
68MP0001853_heart_inflammation1.07911614
69MP0000490_abnormal_crypts_of1.07593715
70MP0003950_abnormal_plasma_membrane1.05886861
71MP0005621_abnormal_cell_physiology1.05535353
72MP0001697_abnormal_embryo_size1.05112989
73MP0002933_joint_inflammation1.03527477
74MP0001845_abnormal_inflammatory_respons1.01189824
75MP0002653_abnormal_ependyma_morphology0.99136427
76MP0002210_abnormal_sex_determination0.98506471
77MP0003123_paternal_imprinting0.98235855
78MP0006082_CNS_inflammation0.98228465
79MP0002396_abnormal_hematopoietic_system0.97768831
80MP0003890_abnormal_embryonic-extraembry0.96518219
81MP0003453_abnormal_keratinocyte_physiol0.95625158
82MP0000313_abnormal_cell_death0.94235686
83MP0008932_abnormal_embryonic_tissue0.94137607
84MP0005380_embryogenesis_phenotype0.93543317
85MP0001672_abnormal_embryogenesis/_devel0.93543317
86MP0005410_abnormal_fertilization0.91986339
87MP0008995_early_reproductive_senescence0.90445230
88MP0003943_abnormal_hepatobiliary_system0.88561480
89MP0003828_pulmonary_edema0.88449631
90MP0001533_abnormal_skeleton_physiology0.88130784
91MP0003984_embryonic_growth_retardation0.87983653
92MP0002163_abnormal_gland_morphology0.87208405
93MP0002088_abnormal_embryonic_growth/wei0.86994987
94MP0005310_abnormal_salivary_gland0.85747865
95MP0001119_abnormal_female_reproductive0.85620942
96MP0002080_prenatal_lethality0.83869034
97MP0002086_abnormal_extraembryonic_tissu0.83724787
98MP0000569_abnormal_digit_pigmentation0.82464465
99MP0002084_abnormal_developmental_patter0.81389311
100MP0002085_abnormal_embryonic_tissue0.79305348

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)3.99605316
2Metaphyseal cupping (HP:0003021)3.28694496
3Recurrent bronchitis (HP:0002837)3.27078849
4Missing ribs (HP:0000921)3.19995110
5Degeneration of anterior horn cells (HP:0002398)2.93390897
6Abnormality of the anterior horn cell (HP:0006802)2.93390897
7Abnormality of the fingertips (HP:0001211)2.93196617
8Cervical subluxation (HP:0003308)2.80118778
9Stomatitis (HP:0010280)2.74655112
10Cutaneous melanoma (HP:0012056)2.65437503
11T lymphocytopenia (HP:0005403)2.64317326
12Birth length less than 3rd percentile (HP:0003561)2.61706799
13Abnormality of T cell number (HP:0011839)2.57005240
14Myositis (HP:0100614)2.54773377
15Carpal bone hypoplasia (HP:0001498)2.53217220
16Recurrent viral infections (HP:0004429)2.52551249
17Bronchitis (HP:0012387)2.49818834
18Prominent nose (HP:0000448)2.43818236
19Flat capital femoral epiphysis (HP:0003370)2.35911774
20Breast hypoplasia (HP:0003187)2.33569532
21Nasal polyposis (HP:0100582)2.30046427
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.29552417
23Myelodysplasia (HP:0002863)2.26115546
24Small epiphyses (HP:0010585)2.25012538
25Recurrent fungal infections (HP:0002841)2.24075448
26Wrist flexion contracture (HP:0001239)2.23801316
27Elevated erythrocyte sedimentation rate (HP:0003565)2.23424138
28Abnormality of chromosome stability (HP:0003220)2.21529433
29Selective tooth agenesis (HP:0001592)2.19535269
30Mild short stature (HP:0003502)2.16162629
31Recurrent abscess formation (HP:0002722)2.12073067
32Orchitis (HP:0100796)2.08504232
33Combined immunodeficiency (HP:0005387)2.08437314
34High pitched voice (HP:0001620)2.06990841
35Eczematoid dermatitis (HP:0000976)2.05432567
36Abnormality of T cells (HP:0002843)2.05295426
37Vertebral hypoplasia (HP:0008417)2.05093181
38Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.05093181
39Lymphopenia (HP:0001888)2.04934142
40Retrobulbar optic neuritis (HP:0100654)2.03781788
41Optic neuritis (HP:0100653)2.03781788
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02913502
43Meckel diverticulum (HP:0002245)2.02466554
44Spinal muscular atrophy (HP:0007269)2.02227343
45IgG deficiency (HP:0004315)2.01777760
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.00886616
47Thrombocytosis (HP:0001894)2.00662341
48Patellar aplasia (HP:0006443)1.98739066
49Abnormality of the labia minora (HP:0012880)1.98271877
50Abnormal spermatogenesis (HP:0008669)1.96048218
51Ulnar deviation of the wrist (HP:0003049)1.95668083
52Irregular vertebral endplates (HP:0003301)1.91131272
53Abnormality of the nasal mucosa (HP:0000433)1.90699244
54Hematochezia (HP:0002573)1.90334131
55Lymphoma (HP:0002665)1.90198165
56Muscle fibrillation (HP:0010546)1.90164352
57Thyroiditis (HP:0100646)1.89132164
58Tongue fasciculations (HP:0001308)1.88343970
59Severe combined immunodeficiency (HP:0004430)1.86140728
60Abnormality of the epiphysis of the femoral head (HP:0010574)1.85839935
61Abnormality of the preputium (HP:0100587)1.85201876
62Male infertility (HP:0003251)1.85098966
63Glossoptosis (HP:0000162)1.84188469
64Absent epiphyses (HP:0010577)1.83104504
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83104504
66IgM deficiency (HP:0002850)1.80619380
67Abnormality of the ileum (HP:0001549)1.79910372
68Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.77400970
69Abnormality of femoral epiphyses (HP:0006499)1.77400970
70Autoimmune thrombocytopenia (HP:0001973)1.76991516
71Bone marrow hypocellularity (HP:0005528)1.76648557
72Acute myeloid leukemia (HP:0004808)1.75217405
73Aplasia/Hypoplasia of the patella (HP:0006498)1.75200822
74Abnormality of the femoral head (HP:0003368)1.74283924
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73034663
76Abnormality of the calcaneus (HP:0008364)1.70226971
77Papillary thyroid carcinoma (HP:0002895)1.69251368
78Persistence of primary teeth (HP:0006335)1.69173554
79Leukopenia (HP:0001882)1.68608021
80Irregular epiphyses (HP:0010582)1.68497846
81Chronic otitis media (HP:0000389)1.68250264
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.67992445
83Leukocytosis (HP:0001974)1.67839136
84Flattened epiphyses (HP:0003071)1.66801000
85Thin ribs (HP:0000883)1.66454098
86IgA deficiency (HP:0002720)1.66082935
87Atrophy/Degeneration involving motor neurons (HP:0007373)1.65930885
88Abnormality of the radial head (HP:0003995)1.65576357
89Aseptic necrosis (HP:0010885)1.64274956
90Chronic mucocutaneous candidiasis (HP:0002728)1.63860629
91Recurrent cutaneous fungal infections (HP:0011370)1.63860629
92Prominent metopic ridge (HP:0005487)1.63437185
93Abnormality of macrophages (HP:0004311)1.63043729
94Eosinophilia (HP:0001880)1.61503415
95Clubbing of toes (HP:0100760)1.60639044
96Spondylolisthesis (HP:0003302)1.60572080
97Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60218191
98Poor head control (HP:0002421)1.59987348
99Sloping forehead (HP:0000340)1.59254046
100Aortic valve stenosis (HP:0001650)1.59171623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK12.57735777
2IRAK32.52209143
3MAP3K142.48330348
4CDC72.37260381
5TESK22.33610904
6TYK22.24934670
7STK102.18363311
8JAK32.14645990
9ACVR1B2.12367447
10PASK2.09394276
11MAP4K12.07874703
12TSSK62.07685346
13ITK2.04889443
14CDK122.00283497
15SRPK11.95281665
16FRK1.89037718
17BLK1.88595735
18SCYL21.83839054
19PBK1.79202658
20TXK1.71776494
21ZAP701.71067694
22NEK21.61446688
23RPS6KA41.60331641
24EIF2AK31.58362299
25STK31.57190525
26IKBKB1.50869024
27CHUK1.48360629
28FGFR31.46445104
29TTK1.46281200
30PDK21.45477023
31STK41.43295655
32TESK11.33991914
33PIM11.33769616
34MELK1.29058788
35TGFBR11.26810211
36JAK11.24405700
37IKBKE1.18401831
38BUB11.16861098
39MAP3K31.15601089
40EEF2K1.15242975
41FGFR41.14074462
42TEC1.11581465
43DYRK31.11339798
44NLK1.10731279
45EPHA31.07284092
46TBK11.06630293
47MARK31.05747030
48ERBB31.05580955
49PLK11.03211010
50MAPK71.02182760
51PIM21.01607545
52PLK30.99719398
53EPHA20.97763776
54LATS10.96493850
55VRK10.95105081
56ATR0.92859628
57AURKB0.89883061
58NEK90.86984196
59BTK0.83263379
60CHEK10.78318241
61KIT0.78310313
62FGFR20.77318760
63LCK0.73701581
64WEE10.73024156
65CSF1R0.72175079
66MAPKAPK30.70413786
67RPS6KB20.69813889
68ATM0.64789002
69CHEK20.64273739
70STK38L0.64053645
71NEK10.63609097
72MKNK10.63512221
73BRD40.63012376
74FLT30.60778556
75PTK60.60388919
76BRSK20.59885464
77CLK10.59235410
78CDK40.57339920
79TRPM70.56979936
80MAP3K80.56439878
81CSK0.55361922
82ERBB40.53492856
83HCK0.53253602
84SYK0.52566665
85LRRK20.51355363
86CDK70.50470179
87MAPKAPK20.49839346
88DYRK1B0.47832448
89PDK30.47564890
90PDK40.47564890
91MAP3K100.46141450
92JAK20.44804295
93CDK20.44210761
94BRAF0.43520118
95TTN0.42962154
96PLK40.42649513
97CCNB10.41325160
98MAPK110.40474216
99KDR0.40376484
100CDK90.38801395

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.22888500
2Primary immunodeficiency_Homo sapiens_hsa053402.12517017
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.98933749
4Mismatch repair_Homo sapiens_hsa034301.98557255
5DNA replication_Homo sapiens_hsa030301.96287081
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96197365
7Measles_Homo sapiens_hsa051621.91895011
8RNA transport_Homo sapiens_hsa030131.90178470
9Homologous recombination_Homo sapiens_hsa034401.85513366
10p53 signaling pathway_Homo sapiens_hsa041151.80678302
11Antigen processing and presentation_Homo sapiens_hsa046121.76531378
12Spliceosome_Homo sapiens_hsa030401.73506913
13RNA degradation_Homo sapiens_hsa030181.73464457
14Leishmaniasis_Homo sapiens_hsa051401.68777814
15Herpes simplex infection_Homo sapiens_hsa051681.68136858
16Basal transcription factors_Homo sapiens_hsa030221.61490597
17Legionellosis_Homo sapiens_hsa051341.60869459
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58045610
19Fanconi anemia pathway_Homo sapiens_hsa034601.57593683
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55454686
21Epstein-Barr virus infection_Homo sapiens_hsa051691.53380012
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.43328295
23Hepatitis B_Homo sapiens_hsa051611.42530179
24RNA polymerase_Homo sapiens_hsa030201.40752293
25T cell receptor signaling pathway_Homo sapiens_hsa046601.39065733
26Viral carcinogenesis_Homo sapiens_hsa052031.38126909
27Osteoclast differentiation_Homo sapiens_hsa043801.36143740
28Graft-versus-host disease_Homo sapiens_hsa053321.34198967
29Base excision repair_Homo sapiens_hsa034101.31753929
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.31537343
31Viral myocarditis_Homo sapiens_hsa054161.30640012
32B cell receptor signaling pathway_Homo sapiens_hsa046621.27281239
33Nucleotide excision repair_Homo sapiens_hsa034201.26922857
34HTLV-I infection_Homo sapiens_hsa051661.26423286
35Influenza A_Homo sapiens_hsa051641.24529032
36Allograft rejection_Homo sapiens_hsa053301.24181232
37Proteasome_Homo sapiens_hsa030501.23875860
38Toxoplasmosis_Homo sapiens_hsa051451.22471809
39Apoptosis_Homo sapiens_hsa042101.21852801
40Small cell lung cancer_Homo sapiens_hsa052221.21563352
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20066979
42Pancreatic cancer_Homo sapiens_hsa052121.14904284
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13181278
44Colorectal cancer_Homo sapiens_hsa052101.12200263
45Hematopoietic cell lineage_Homo sapiens_hsa046401.12049167
46TNF signaling pathway_Homo sapiens_hsa046681.11833130
47Shigellosis_Homo sapiens_hsa051311.11733636
48Chronic myeloid leukemia_Homo sapiens_hsa052201.10552031
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07047881
50Type I diabetes mellitus_Homo sapiens_hsa049401.06379265
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05643192
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04584127
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04371297
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04240279
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03479497
56Non-homologous end-joining_Homo sapiens_hsa034501.01451311
57Malaria_Homo sapiens_hsa051441.00637267
58Notch signaling pathway_Homo sapiens_hsa043300.99637418
59MicroRNAs in cancer_Homo sapiens_hsa052060.95207450
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95091406
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93470642
62Pyrimidine metabolism_Homo sapiens_hsa002400.88533701
63mTOR signaling pathway_Homo sapiens_hsa041500.88313610
64Thyroid cancer_Homo sapiens_hsa052160.84399274
65TGF-beta signaling pathway_Homo sapiens_hsa043500.84259824
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82731956
67mRNA surveillance pathway_Homo sapiens_hsa030150.82502211
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81159843
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79511512
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.78779063
71Tuberculosis_Homo sapiens_hsa051520.78679142
72One carbon pool by folate_Homo sapiens_hsa006700.78442767
73FoxO signaling pathway_Homo sapiens_hsa040680.77540211
74Prolactin signaling pathway_Homo sapiens_hsa049170.77163788
75Acute myeloid leukemia_Homo sapiens_hsa052210.76771878
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75313571
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74927416
78Autoimmune thyroid disease_Homo sapiens_hsa053200.74017513
79Prostate cancer_Homo sapiens_hsa052150.63337730
80Oocyte meiosis_Homo sapiens_hsa041140.63018381
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62312128
82Chemokine signaling pathway_Homo sapiens_hsa040620.62287436
83Vitamin B6 metabolism_Homo sapiens_hsa007500.58099304
84Other glycan degradation_Homo sapiens_hsa005110.56901283
85Hepatitis C_Homo sapiens_hsa051600.55090349
86HIF-1 signaling pathway_Homo sapiens_hsa040660.54853322
87Pertussis_Homo sapiens_hsa051330.53682034
88Pathways in cancer_Homo sapiens_hsa052000.52579524
89Salmonella infection_Homo sapiens_hsa051320.52522010
90Adherens junction_Homo sapiens_hsa045200.52266580
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50736741
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.50652011
93Pentose phosphate pathway_Homo sapiens_hsa000300.49895780
94Protein export_Homo sapiens_hsa030600.48720634
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48324459
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.47907849
97Asthma_Homo sapiens_hsa053100.46405424
98Phagosome_Homo sapiens_hsa041450.44650976
99Renal cell carcinoma_Homo sapiens_hsa052110.44408494
100Lysosome_Homo sapiens_hsa041420.43592331

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