PRAMEF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.31544877
2positive regulation of protein homooligomerization (GO:0032464)5.95671617
3transcription from mitochondrial promoter (GO:0006390)5.57297219
4meiosis I (GO:0007127)5.49119009
5rRNA modification (GO:0000154)4.93274471
6regulation of DNA methylation (GO:0044030)4.63062748
7chaperone-mediated protein transport (GO:0072321)4.42607586
8rRNA methylation (GO:0031167)4.37227284
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.29113851
10regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.23183340
11regulation of acrosome reaction (GO:0060046)4.05705404
12autophagic vacuole assembly (GO:0000045)4.04976573
13* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)33.8468978
14multicellular organism reproduction (GO:0032504)3.91061931
15ribosome assembly (GO:0042255)3.87179871
16mitotic metaphase plate congression (GO:0007080)3.82955145
17male meiosis (GO:0007140)3.80291696
18termination of RNA polymerase III transcription (GO:0006386)3.63840933
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.63840933
20ventricular cardiac muscle cell development (GO:0055015)3.60272927
21regulation of G0 to G1 transition (GO:0070316)3.44638377
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.22529353
23mitochondrial RNA metabolic process (GO:0000959)3.21571088
24very-low-density lipoprotein particle assembly (GO:0034379)3.21377981
25attachment of spindle microtubules to kinetochore (GO:0008608)3.16518118
26regulation of spindle organization (GO:0090224)3.13905675
27regulation of protein homooligomerization (GO:0032462)3.08165936
28aggressive behavior (GO:0002118)3.06812993
29skeletal muscle tissue regeneration (GO:0043403)3.04096550
30metaphase plate congression (GO:0051310)3.00825177
31* regulation of retinoic acid receptor signaling pathway (GO:0048385)28.3092184
32piRNA metabolic process (GO:0034587)2.95311596
33positive regulation of chromosome segregation (GO:0051984)2.94580555
34protein K6-linked ubiquitination (GO:0085020)2.91456900
35positive regulation of cAMP-mediated signaling (GO:0043950)2.90268171
36regulation of oxidative phosphorylation (GO:0002082)2.84549613
37regulation of female gonad development (GO:2000194)2.83415880
38polyamine biosynthetic process (GO:0006596)2.83011322
39rRNA processing (GO:0006364)2.81268768
40mitotic chromosome condensation (GO:0007076)2.80358080
41regulation of female receptivity (GO:0045924)2.79106431
42ribosome biogenesis (GO:0042254)2.77733585
43maturation of 5.8S rRNA (GO:0000460)2.75716151
44regulation of cytokine production involved in inflammatory response (GO:1900015)2.75178912
45meiotic cell cycle (GO:0051321)2.73228887
46rRNA metabolic process (GO:0016072)2.71258212
47meiotic nuclear division (GO:0007126)2.71112855
48regulation of mitotic spindle organization (GO:0060236)2.68848410
49transcription from RNA polymerase III promoter (GO:0006383)2.68262748
50maturation of SSU-rRNA (GO:0030490)2.66365208
51regulation of penile erection (GO:0060405)2.66003267
52activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.65631576
53reproduction (GO:0000003)2.64073317
54response to UV-C (GO:0010225)2.61428628
55snRNA transcription (GO:0009301)2.59849743
56proteasome assembly (GO:0043248)2.59800914
57detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.59660434
58meiotic cell cycle process (GO:1903046)2.58979702
59positive regulation of protein oligomerization (GO:0032461)2.58145325
60N-terminal protein amino acid acetylation (GO:0006474)2.58083339
61positive regulation of prostaglandin secretion (GO:0032308)2.55616979
62drinking behavior (GO:0042756)2.53983901
63pseudouridine synthesis (GO:0001522)2.52104737
64regulation of uterine smooth muscle contraction (GO:0070472)2.51841099
65ribonucleoprotein complex biogenesis (GO:0022613)2.46084401
66hyperosmotic salinity response (GO:0042538)2.44213044
67negative regulation of reproductive process (GO:2000242)2.42176198
68histone mRNA metabolic process (GO:0008334)2.40069316
69positive regulation of catecholamine secretion (GO:0033605)2.38972569
70female mating behavior (GO:0060180)2.38167781
71regulation of meiosis I (GO:0060631)2.37784627
72transcription elongation from RNA polymerase II promoter (GO:0006368)2.36767673
73chaperone mediated protein folding requiring cofactor (GO:0051085)2.36286804
74regulation of transforming growth factor beta2 production (GO:0032909)2.35560888
75binding of sperm to zona pellucida (GO:0007339)2.32075743
76cellular biogenic amine biosynthetic process (GO:0042401)2.30535093
77positive regulation of digestive system process (GO:0060456)2.29579031
78regulation of transforming growth factor beta1 production (GO:0032908)2.28991986
79DNA-templated transcription, elongation (GO:0006354)2.28843713
80protein localization to chromosome, centromeric region (GO:0071459)2.28059322
81intestinal epithelial cell development (GO:0060576)2.27850382
82oocyte development (GO:0048599)2.26096850
83DNA methylation involved in gamete generation (GO:0043046)2.24817022
84ribosomal small subunit biogenesis (GO:0042274)2.24230283
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.23721717
86DNA replication checkpoint (GO:0000076)2.21854366
87regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.21584130
88telomere maintenance via telomere lengthening (GO:0010833)2.19919041
89DNA-templated transcription, termination (GO:0006353)2.19339548
90mitotic sister chromatid segregation (GO:0000070)2.19099161
91pyrimidine-containing compound transmembrane transport (GO:0072531)2.19052061
92CENP-A containing nucleosome assembly (GO:0034080)2.18891791
93regulation of cellular respiration (GO:0043457)2.18777518
94amine biosynthetic process (GO:0009309)2.18523359
95positive regulation of cardiac muscle cell proliferation (GO:0060045)2.18418876
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.17815123
97response to acidic pH (GO:0010447)2.17541668
98negative regulation of RNA splicing (GO:0033119)2.17425608
99protein targeting to mitochondrion (GO:0006626)2.16939736
100negative regulation of digestive system process (GO:0060457)2.14317438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_21737748_ChIP-Seq_TLL_Human4.66104587
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28386140
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.16344482
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97143063
5ZNF274_21170338_ChIP-Seq_K562_Hela3.91603625
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.75175921
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.56229847
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.56229847
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.56229847
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.34309404
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.29763350
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.28388075
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88421375
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82998735
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81898587
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80003652
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66510940
18E2F7_22180533_ChIP-Seq_HELA_Human2.58482926
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56251725
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.51923470
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43987253
22EZH2_22144423_ChIP-Seq_EOC_Human2.41263057
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30144789
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20201101
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19553441
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.15083846
27VDR_23849224_ChIP-Seq_CD4+_Human2.06154089
28* ETV1_20927104_ChIP-Seq_GIST48_Human2.01295960
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97219278
30* RBPJ_21746931_ChIP-Seq_IB4_Human1.84901682
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.82697779
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79117684
33TTF2_22483619_ChIP-Seq_HELA_Human1.74811432
34* PHF8_20622853_ChIP-Seq_HELA_Human1.71607565
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71058823
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70755701
37GABP_19822575_ChIP-Seq_HepG2_Human1.70562970
38* NFYB_21822215_ChIP-Seq_K562_Human1.66860889
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62633529
40AR_21909140_ChIP-Seq_LNCAP_Human1.61883479
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61341101
42* TBL1_22424771_ChIP-Seq_293T_Human1.60362561
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59613301
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57033602
45MYC_18940864_ChIP-ChIP_HL60_Human1.56926315
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53065437
47* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.50357610
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48969103
49TP53_22573176_ChIP-Seq_HFKS_Human1.47869133
50FOXP3_21729870_ChIP-Seq_TREG_Human1.47035363
51* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.46895798
52* GATA6_21074721_ChIP-Seq_CACO-2_Human1.45660382
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.39376532
54IRF1_19129219_ChIP-ChIP_H3396_Human1.35153597
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34886787
56ELK1_19687146_ChIP-ChIP_HELA_Human1.33055653
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30188256
58* HNFA_21074721_ChIP-Seq_CACO-2_Human1.25835914
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25804117
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.25228608
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.23542364
62XRN2_22483619_ChIP-Seq_HELA_Human1.22125424
63PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21045189
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19208557
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18971192
66LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14703386
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13741588
68* NFYA_21822215_ChIP-Seq_K562_Human1.12024058
69LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10820958
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06163902
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03159036
72MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99696211
73KDM5A_27292631_Chip-Seq_BREAST_Human0.99141426
74GATA1_26923725_Chip-Seq_HPCs_Mouse0.97301395
75ZNF263_19887448_ChIP-Seq_K562_Human0.94869382
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94615360
77VDR_22108803_ChIP-Seq_LS180_Human0.92732773
78DCP1A_22483619_ChIP-Seq_HELA_Human0.90431500
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90217794
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89254856
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.88187986
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88154257
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88100598
84RAC3_21632823_ChIP-Seq_H3396_Human0.87766345
85E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87724458
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87548258
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87355749
88HOXB7_26014856_ChIP-Seq_BT474_Human0.87182782
89NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85740728
90NANOG_20526341_ChIP-Seq_ESCs_Human0.83404096
91CBX2_22325352_ChIP-Seq_293T-Rex_Human0.81848419
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79807983
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79457283
94STAT1_20625510_ChIP-Seq_HELA_Human0.78273306
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78013124
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.76134885
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75535366
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75305975
99CTCF_20526341_ChIP-Seq_ESCs_Human0.74870546
100* NCOR_22424771_ChIP-Seq_293T_Human0.74186095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity7.17518175
2MP0005423_abnormal_somatic_nervous6.24322035
3MP0006292_abnormal_olfactory_placode4.57084165
4MP0003718_maternal_effect4.33807043
5MP0003693_abnormal_embryo_hatching3.50110236
6MP0003646_muscle_fatigue2.81179016
7MP0009379_abnormal_foot_pigmentation2.79335024
8MP0008260_abnormal_autophagy2.73983233
9MP0004957_abnormal_blastocyst_morpholog2.70111607
10MP0003111_abnormal_nucleus_morphology2.49672557
11MP0008877_abnormal_DNA_methylation2.46819617
12MP0002127_abnormal_cardiovascular_syste2.29712512
13MP0008058_abnormal_DNA_repair2.14534532
14MP0003077_abnormal_cell_cycle2.06224658
15MP0001929_abnormal_gametogenesis2.05406848
16MP0002160_abnormal_reproductive_system2.02431436
17MP0002210_abnormal_sex_determination2.00581163
18MP0005394_taste/olfaction_phenotype1.92939976
19MP0005499_abnormal_olfactory_system1.92939976
20MP0002277_abnormal_respiratory_mucosa1.88737557
21MP0010094_abnormal_chromosome_stability1.86978374
22MP0003136_yellow_coat_color1.84956670
23MP0005395_other_phenotype1.66222679
24MP0010307_abnormal_tumor_latency1.65558198
25MP0009333_abnormal_splenocyte_physiolog1.63548440
26MP0005389_reproductive_system_phenotype1.61202314
27MP0005410_abnormal_fertilization1.53816872
28MP0008789_abnormal_olfactory_epithelium1.49474499
29MP0006036_abnormal_mitochondrial_physio1.41716631
30MP0000653_abnormal_sex_gland1.33252229
31MP0001672_abnormal_embryogenesis/_devel1.29696450
32MP0005380_embryogenesis_phenotype1.29696450
33MP0003698_abnormal_male_reproductive1.28941403
34MP0001145_abnormal_male_reproductive1.24903503
35MP0003938_abnormal_ear_development1.23991243
36MP0005647_abnormal_sex_gland1.20053122
37MP0004215_abnormal_myocardial_fiber1.18441417
38MP0008057_abnormal_DNA_replication1.18236042
39MP0006035_abnormal_mitochondrial_morpho1.17454178
40MP0002161_abnormal_fertility/fecundity1.17367588
41MP0000372_irregular_coat_pigmentation1.15947212
42MP0001697_abnormal_embryo_size1.15921624
43MP0003699_abnormal_female_reproductive1.15792272
44MP0008932_abnormal_embryonic_tissue1.11315415
45MP0006276_abnormal_autonomic_nervous1.11095818
46MP0003195_calcinosis1.10947597
47MP0001529_abnormal_vocalization1.10007797
48MP0009840_abnormal_foam_cell1.09533060
49MP0000358_abnormal_cell_content/1.07000052
50MP0003984_embryonic_growth_retardation1.06929886
51MP0002138_abnormal_hepatobiliary_system1.04840718
52MP0000350_abnormal_cell_proliferation1.04672807
53MP0002088_abnormal_embryonic_growth/wei1.03296266
54MP0005646_abnormal_pituitary_gland1.00236245
55MP0001881_abnormal_mammary_gland1.00040187
56MP0001730_embryonic_growth_arrest0.99581289
57MP0003186_abnormal_redox_activity0.98272630
58MP0001293_anophthalmia0.97576241
59MP0008995_early_reproductive_senescence0.96351699
60MP0004885_abnormal_endolymph0.91046140
61MP0004019_abnormal_vitamin_homeostasis0.90966289
62MP0010030_abnormal_orbit_morphology0.86860991
63MP0000049_abnormal_middle_ear0.86639282
64MP0003943_abnormal_hepatobiliary_system0.86160648
65MP0001119_abnormal_female_reproductive0.84135065
66MP0002735_abnormal_chemical_nociception0.82922386
67MP0001485_abnormal_pinna_reflex0.80568713
68MP0005551_abnormal_eye_electrophysiolog0.79475036
69MP0001919_abnormal_reproductive_system0.79220418
70MP0001968_abnormal_touch/_nociception0.77932608
71MP0005085_abnormal_gallbladder_physiolo0.75637249
72MP0000750_abnormal_muscle_regeneration0.75059849
73MP0004142_abnormal_muscle_tone0.72626176
74MP0002085_abnormal_embryonic_tissue0.72367228
75MP0003121_genomic_imprinting0.72168320
76MP0000647_abnormal_sebaceous_gland0.71769686
77MP0002254_reproductive_system_inflammat0.71042967
78MP0002084_abnormal_developmental_patter0.70852514
79MP0000015_abnormal_ear_pigmentation0.70743686
80MP0001666_abnormal_nutrient_absorption0.70704614
81MP0003936_abnormal_reproductive_system0.70207816
82MP0003567_abnormal_fetal_cardiomyocyte0.70074938
83MP0000631_abnormal_neuroendocrine_gland0.69828355
84MP0003890_abnormal_embryonic-extraembry0.69805758
85MP0003880_abnormal_central_pattern0.69713473
86MP0003119_abnormal_digestive_system0.68902048
87MP0005367_renal/urinary_system_phenotyp0.68744588
88MP0000516_abnormal_urinary_system0.68744588
89MP0002080_prenatal_lethality0.67185249
90MP0001286_abnormal_eye_development0.65888504
91MP0005174_abnormal_tail_pigmentation0.63192668
92MP0001502_abnormal_circadian_rhythm0.62727231
93MP0005451_abnormal_body_composition0.62564334
94MP0003950_abnormal_plasma_membrane0.60651366
95MP0002095_abnormal_skin_pigmentation0.60088864
96MP0002736_abnormal_nociception_after0.59735930
97MP0002873_normal_phenotype0.59486855
98MP0002169_no_abnormal_phenotype0.59230679
99MP0005360_urolithiasis0.58729084
100MP0000490_abnormal_crypts_of0.57670129

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.15577331
2Double outlet right ventricle (HP:0001719)4.60993825
3Congenital malformation of the right heart (HP:0011723)4.60993825
4Birth length less than 3rd percentile (HP:0003561)4.22277500
5Aplasia/hypoplasia of the uterus (HP:0008684)4.17478950
6Patent foramen ovale (HP:0001655)4.17060526
7Abnormal pancreas size (HP:0012094)4.13619101
8Carpal bone hypoplasia (HP:0001498)3.91577405
9Abnormal umbilical cord blood vessels (HP:0011403)3.67933868
10Single umbilical artery (HP:0001195)3.67933868
11Abnormality of the fetal cardiovascular system (HP:0010948)3.67933868
12Abnormality of the aortic arch (HP:0012303)3.55037031
13Aplasia/Hypoplasia involving the musculature (HP:0001460)3.46616255
14Hypoplasia of the uterus (HP:0000013)3.37330978
15Premature ovarian failure (HP:0008209)3.28662289
16Malnutrition (HP:0004395)3.22437084
17Ureteral duplication (HP:0000073)3.17176904
18Microvesicular hepatic steatosis (HP:0001414)3.15427614
19Hypercortisolism (HP:0001578)2.98325392
20Short tibia (HP:0005736)2.83601213
21Abnormality of the septum pellucidum (HP:0007375)2.75163332
22Preauricular pit (HP:0004467)2.74502105
23Periauricular skin pits (HP:0100277)2.74502105
24Hypoglycemic seizures (HP:0002173)2.73762959
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.73336527
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71880826
27Hypoplasia of the fovea (HP:0007750)2.71783135
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.71783135
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59084708
30Constricted visual fields (HP:0001133)2.58488362
31Hypergonadotropic hypogonadism (HP:0000815)2.58049508
32Pendular nystagmus (HP:0012043)2.57838029
33Fused cervical vertebrae (HP:0002949)2.56710337
34Concave nail (HP:0001598)2.54588217
35Abnormality of magnesium homeostasis (HP:0004921)2.53711089
36Hyperglycemia (HP:0003074)2.50232240
37Infertility (HP:0000789)2.46889257
38Horseshoe kidney (HP:0000085)2.43490561
39Limb dystonia (HP:0002451)2.40923312
40Hypophosphatemic rickets (HP:0004912)2.39614295
41Dysphonia (HP:0001618)2.39585764
42Abnormal rod and cone electroretinograms (HP:0008323)2.39068257
43Absent radius (HP:0003974)2.29819698
44Cleft eyelid (HP:0000625)2.29596469
45Glycosuria (HP:0003076)2.27719761
46Abnormality of urine glucose concentration (HP:0011016)2.27719761
47Microretrognathia (HP:0000308)2.24554328
48Hypomagnesemia (HP:0002917)2.22988843
49Meckel diverticulum (HP:0002245)2.22010322
50Abnormality of the ileum (HP:0001549)2.21454864
51Short 1st metacarpal (HP:0010034)2.21061971
52Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.21061971
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20250363
54Abnormality of alanine metabolism (HP:0010916)2.20250363
55Hyperalaninemia (HP:0003348)2.20250363
56Progressive muscle weakness (HP:0003323)2.20185653
57Symptomatic seizures (HP:0011145)2.18635312
58Aplasia involving forearm bones (HP:0009822)2.18262726
59Absent forearm bone (HP:0003953)2.18262726
60Sensory axonal neuropathy (HP:0003390)2.17736650
61Attenuation of retinal blood vessels (HP:0007843)2.16273924
62Midline defect of the nose (HP:0004122)2.15426827
63Absent thumb (HP:0009777)2.15207769
64Cerebral hypomyelination (HP:0006808)2.14997791
65Abnormality of the fovea (HP:0000493)2.14842152
66Facial cleft (HP:0002006)2.14511158
67Stenosis of the external auditory canal (HP:0000402)2.13497703
68Ileus (HP:0002595)2.12712523
693-Methylglutaconic aciduria (HP:0003535)2.11437900
70Increased serum lactate (HP:0002151)2.11005268
71Posterior subcapsular cataract (HP:0007787)2.10543523
72Reticulocytopenia (HP:0001896)2.09503057
73Absent septum pellucidum (HP:0001331)2.09101215
74Rhinitis (HP:0012384)2.08536780
75Abnormality of the preputium (HP:0100587)2.08214099
76Abnormal biliary tract morphology (HP:0012440)2.03305778
77Multiple enchondromatosis (HP:0005701)2.02089714
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01626284
79Abnormality of cells of the erythroid lineage (HP:0012130)2.00656779
80Abnormal number of erythroid precursors (HP:0012131)1.99655440
81Tetany (HP:0001281)1.99108835
82Reduced antithrombin III activity (HP:0001976)1.97145947
83Median cleft lip (HP:0000161)1.94669679
84Osteomalacia (HP:0002749)1.94248520
85Abnormality of the 1st metacarpal (HP:0010009)1.94194562
86Abnormal spermatogenesis (HP:0008669)1.91796363
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90707895
88Abnormality of the umbilical cord (HP:0010881)1.89009042
89CNS hypomyelination (HP:0003429)1.88429064
90Azoospermia (HP:0000027)1.88039758
91Abnormality of the pons (HP:0007361)1.87643571
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87273251
93Aplasia/hypoplasia of the humerus (HP:0006507)1.87053202
94Supernumerary spleens (HP:0009799)1.85762557
95Truncus arteriosus (HP:0001660)1.83111956
96Breast hypoplasia (HP:0003187)1.80517469
97Pancreatic cysts (HP:0001737)1.79658280
98Hyperinsulinemic hypoglycemia (HP:0000825)1.78075435
99Hypoplasia of the pons (HP:0012110)1.77091358
100Skin pits (HP:0100276)1.76650816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.00596502
2SRPK14.35872587
3TESK24.12435852
4PBK3.17838670
5STK163.10139158
6PDK23.03778676
7TRIM282.95772237
8LATS22.90819235
9CDK192.36630154
10WNK32.33081643
11PLK12.19619677
12TAOK32.09400002
13NEK61.95810336
14PLK31.93787315
15BRSK21.92205122
16BRSK11.90665082
17NEK21.76455679
18AURKA1.74975819
19MARK31.55316175
20AURKB1.46971414
21NUAK11.34887125
22FRK1.34379184
23EIF2AK31.34114394
24STK391.30395399
25DYRK31.29726339
26PINK11.23282682
27BMX1.22021364
28CHEK11.17213129
29OXSR11.14721587
30CHEK21.12568361
31ZAK1.10160207
32PLK41.06976167
33PKN11.06919133
34CDC71.00077684
35PRKCI0.99083210
36STK40.96404778
37PIM10.93370212
38CSNK2A10.92404726
39CSNK1E0.88989012
40WNK40.88791976
41GSK3A0.87742894
42GRK10.87121657
43TTK0.86349894
44TLK10.84937366
45MAP3K40.84606897
46PAK10.83321008
47MAP3K50.81766812
48CDK70.76909417
49PAK60.75853178
50CSNK2A20.73390536
51NTRK30.72315119
52ATR0.71776278
53STK100.71063638
54MAP4K20.70367424
55EPHA40.70197341
56ACVR1B0.69202731
57MST40.69036488
58STK38L0.68700019
59TNIK0.66932928
60PRKCG0.61704085
61STK30.61671926
62PAK20.60629123
63AKT20.60243131
64CDK20.59569164
65WEE10.58771029
66CDK90.58680228
67CSNK1A10.56507143
68CDK10.55077461
69AKT30.54871789
70RAF10.53583592
71PRKCE0.53456810
72MAP3K90.53333400
73BMPR1B0.51537554
74VRK10.51321650
75MELK0.50987114
76INSRR0.49401126
77PRKG10.49235668
78ATM0.47167901
79PHKG10.43604984
80PHKG20.43604984
81PIM20.42665162
82MAP2K70.42621415
83PRKACB0.38939930
84CAMK40.38494368
85ABL20.38277290
86MAPK130.38038767
87LRRK20.35659162
88MAPK110.35320802
89GSK3B0.34019730
90EIF2AK10.32830570
91EIF2AK20.32759648
92PIK3CG0.32476145
93RPS6KA10.31421175
94PRKACA0.30347719
95NME10.30329480
96MAPK10.29718255
97PRKD20.28599116
98PRKD10.28546235
99MAP3K80.27953014
100MARK10.27804140

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.07858089
2Basal transcription factors_Homo sapiens_hsa030225.02160371
3Regulation of autophagy_Homo sapiens_hsa041404.24557995
4RNA polymerase_Homo sapiens_hsa030204.14023924
5Ribosome_Homo sapiens_hsa030103.61782321
6RNA transport_Homo sapiens_hsa030132.99722469
7mRNA surveillance pathway_Homo sapiens_hsa030152.80816544
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.65688329
9Folate biosynthesis_Homo sapiens_hsa007902.60165382
10Spliceosome_Homo sapiens_hsa030402.54557881
11Cell cycle_Homo sapiens_hsa041102.09340558
12Oocyte meiosis_Homo sapiens_hsa041141.90536980
13Steroid biosynthesis_Homo sapiens_hsa001001.85326958
14Taste transduction_Homo sapiens_hsa047421.85158775
15p53 signaling pathway_Homo sapiens_hsa041151.84660831
16RNA degradation_Homo sapiens_hsa030181.80534395
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79522136
18Pyrimidine metabolism_Homo sapiens_hsa002401.74723501
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65999499
20Homologous recombination_Homo sapiens_hsa034401.57844271
21Fanconi anemia pathway_Homo sapiens_hsa034601.57092270
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.50974549
23Huntingtons disease_Homo sapiens_hsa050161.47837906
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.44957929
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43901844
26Mismatch repair_Homo sapiens_hsa034301.34116682
27Proteasome_Homo sapiens_hsa030501.33825618
28Collecting duct acid secretion_Homo sapiens_hsa049661.30529959
29Parkinsons disease_Homo sapiens_hsa050121.28848412
30DNA replication_Homo sapiens_hsa030301.19950435
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19729152
32Base excision repair_Homo sapiens_hsa034101.19252378
33Oxidative phosphorylation_Homo sapiens_hsa001901.16370622
34Protein export_Homo sapiens_hsa030601.15024521
35Purine metabolism_Homo sapiens_hsa002301.12027669
36Cardiac muscle contraction_Homo sapiens_hsa042601.04683469
37Sulfur metabolism_Homo sapiens_hsa009201.02682375
38Ovarian steroidogenesis_Homo sapiens_hsa049131.01971551
39Dorso-ventral axis formation_Homo sapiens_hsa043200.97585033
40Fatty acid elongation_Homo sapiens_hsa000620.96713635
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.89600043
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88910037
43Fatty acid biosynthesis_Homo sapiens_hsa000610.82746908
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78905431
45Nucleotide excision repair_Homo sapiens_hsa034200.75521091
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.75453267
47Olfactory transduction_Homo sapiens_hsa047400.71945587
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71345033
49Caffeine metabolism_Homo sapiens_hsa002320.68697340
50Epstein-Barr virus infection_Homo sapiens_hsa051690.63156973
51Synaptic vesicle cycle_Homo sapiens_hsa047210.62653705
52Insulin secretion_Homo sapiens_hsa049110.59284599
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58238598
54Inositol phosphate metabolism_Homo sapiens_hsa005620.55840866
55Selenocompound metabolism_Homo sapiens_hsa004500.54762626
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54400758
57Glutathione metabolism_Homo sapiens_hsa004800.50970165
58Nicotine addiction_Homo sapiens_hsa050330.50701233
59Wnt signaling pathway_Homo sapiens_hsa043100.49787457
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48777440
61Viral carcinogenesis_Homo sapiens_hsa052030.47794469
62Phototransduction_Homo sapiens_hsa047440.46572373
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45267190
64Metabolic pathways_Homo sapiens_hsa011000.42264464
65ABC transporters_Homo sapiens_hsa020100.40015795
66Herpes simplex infection_Homo sapiens_hsa051680.39414312
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.39156379
68Linoleic acid metabolism_Homo sapiens_hsa005910.38083464
69Arginine and proline metabolism_Homo sapiens_hsa003300.38031568
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36718281
71Nitrogen metabolism_Homo sapiens_hsa009100.35013397
72Mineral absorption_Homo sapiens_hsa049780.33911088
73Propanoate metabolism_Homo sapiens_hsa006400.32348470
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32089074
75Non-homologous end-joining_Homo sapiens_hsa034500.31531038
76Hedgehog signaling pathway_Homo sapiens_hsa043400.31287510
77Ether lipid metabolism_Homo sapiens_hsa005650.29889123
78Sphingolipid metabolism_Homo sapiens_hsa006000.27982894
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27511521
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27342875
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26808297
82MicroRNAs in cancer_Homo sapiens_hsa052060.26596851
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24455534
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20687084
85Serotonergic synapse_Homo sapiens_hsa047260.19973242
86TGF-beta signaling pathway_Homo sapiens_hsa043500.16769272
87Vibrio cholerae infection_Homo sapiens_hsa051100.16557573
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14331321
89Alzheimers disease_Homo sapiens_hsa050100.14308276
90Sulfur relay system_Homo sapiens_hsa041220.14131529
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13071003
92GABAergic synapse_Homo sapiens_hsa047270.12731473
93Pyruvate metabolism_Homo sapiens_hsa006200.11640389
94Hippo signaling pathway_Homo sapiens_hsa043900.10083691
95Morphine addiction_Homo sapiens_hsa050320.06960285
96Circadian rhythm_Homo sapiens_hsa047100.06488183
97Calcium signaling pathway_Homo sapiens_hsa040200.06022554
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04361477
99One carbon pool by folate_Homo sapiens_hsa006700.03757226
100beta-Alanine metabolism_Homo sapiens_hsa004100.03007508

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