PRAMEF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)6.58460375
2positive regulation of uterine smooth muscle contraction (GO:0070474)5.94149585
3multicellular organism reproduction (GO:0032504)5.73897458
4regulation of female gonad development (GO:2000194)5.72584246
5regulation of cytokine production involved in inflammatory response (GO:1900015)5.14048822
6* negative regulation of retinoic acid receptor signaling pathway (GO:0048387)42.5562495
7male meiosis I (GO:0007141)4.95663770
8regulation of female receptivity (GO:0045924)4.59265826
9regulation of uterine smooth muscle contraction (GO:0070472)4.59070237
10aggressive behavior (GO:0002118)4.36782054
11protein kinase C signaling (GO:0070528)4.30302046
12meiosis I (GO:0007127)4.23741136
13regulation of DNA methylation (GO:0044030)4.14635800
14drinking behavior (GO:0042756)4.08307207
15positive regulation of humoral immune response (GO:0002922)4.06720705
16* regulation of retinoic acid receptor signaling pathway (GO:0048385)35.3393449
17regulation of penile erection (GO:0060405)3.97817271
18positive regulation of prostaglandin secretion (GO:0032308)3.97559468
19female mating behavior (GO:0060180)3.94141832
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.93249063
21response to acidic pH (GO:0010447)3.90379092
22glycine transport (GO:0015816)3.87498399
23reproduction (GO:0000003)3.81138745
24hyperosmotic salinity response (GO:0042538)3.77331370
25oocyte development (GO:0048599)3.76854896
26negative regulation of digestive system process (GO:0060457)3.71232134
27cellular response to pH (GO:0071467)3.70681746
28positive regulation of catecholamine secretion (GO:0033605)3.66036570
29sleep (GO:0030431)3.61944751
30negative regulation of reproductive process (GO:2000242)3.53834049
31positive regulation of digestive system process (GO:0060456)3.52922125
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36263972
33regulation of prostaglandin secretion (GO:0032306)3.35276897
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18149020
35mitotic chromosome condensation (GO:0007076)3.10557360
36binding of sperm to zona pellucida (GO:0007339)3.07779026
37maternal behavior (GO:0042711)3.01191620
38regulation of norepinephrine secretion (GO:0014061)2.99701682
39L-amino acid import (GO:0043092)2.91812823
40maturation of SSU-rRNA (GO:0030490)2.89501998
41positive regulation of reproductive process (GO:2000243)2.88453062
42male meiosis (GO:0007140)2.78567737
43rRNA modification (GO:0000154)2.77087334
44rRNA methylation (GO:0031167)2.72898404
45sperm-egg recognition (GO:0035036)2.65602511
46parental behavior (GO:0060746)2.62953835
47positive regulation of icosanoid secretion (GO:0032305)2.62272100
48single fertilization (GO:0007338)2.52354902
49meiotic cell cycle (GO:0051321)2.49516724
50N-terminal protein amino acid acetylation (GO:0006474)2.46738017
51histone H3-K9 demethylation (GO:0033169)2.44116379
52positive regulation of fatty acid transport (GO:2000193)2.43112710
53regulation of steroid hormone secretion (GO:2000831)2.37880524
54positive regulation of renal sodium excretion (GO:0035815)2.30226807
55chromosome condensation (GO:0030261)2.27618335
56response to food (GO:0032094)2.25705450
57transcription from mitochondrial promoter (GO:0006390)2.22815276
58regulation of calcium ion-dependent exocytosis (GO:0017158)2.22064227
59telomere maintenance via telomere lengthening (GO:0010833)2.19967398
60mitotic metaphase plate congression (GO:0007080)2.12919078
61cell-cell recognition (GO:0009988)2.11904639
62fertilization (GO:0009566)2.11890550
63regulation of reproductive process (GO:2000241)2.11361302
64regulation of G0 to G1 transition (GO:0070316)2.10803782
65snRNA transcription (GO:0009301)2.10578863
66amino acid import (GO:0043090)2.10553240
67ventricular cardiac muscle cell development (GO:0055015)2.08907433
68meiotic nuclear division (GO:0007126)2.08839020
69grooming behavior (GO:0007625)2.05128188
70detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.04561605
71regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.04337954
72regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.02785677
73regulation of urine volume (GO:0035809)2.00660753
74regulation of spindle organization (GO:0090224)2.00094177
75skeletal muscle tissue regeneration (GO:0043403)1.99940409
76regulation of histone H3-K9 methylation (GO:0051570)1.99127861
77termination of RNA polymerase III transcription (GO:0006386)1.98934599
78transcription elongation from RNA polymerase III promoter (GO:0006385)1.98934599
79piRNA metabolic process (GO:0034587)1.98793590
80translational termination (GO:0006415)1.96711653
81viral transcription (GO:0019083)1.95878315
82chaperone-mediated protein transport (GO:0072321)1.95553124
83sensory perception of taste (GO:0050909)1.94770416
84chaperone mediated protein folding requiring cofactor (GO:0051085)1.94179241
85regulation of mitotic spindle organization (GO:0060236)1.93648652
86protein K6-linked ubiquitination (GO:0085020)1.92997133
87female gamete generation (GO:0007292)1.90666886
88phosphorelay signal transduction system (GO:0000160)1.89290680
89regulation of icosanoid secretion (GO:0032303)1.88689673
90regulation of cell cycle G2/M phase transition (GO:1902749)1.88388415
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)1.87887623
92autophagic vacuole assembly (GO:0000045)1.85298977
93DNA packaging (GO:0006323)1.82710723
94response to prostaglandin E (GO:0034695)1.82687377
95metaphase plate congression (GO:0051310)1.81116155
96positive regulation of smooth muscle contraction (GO:0045987)1.79200067
97regulation of exit from mitosis (GO:0007096)1.78414094
98meiotic cell cycle process (GO:1903046)1.77663080
99regulation of sensory perception of pain (GO:0051930)1.77125499
100regulation of sensory perception (GO:0051931)1.77125499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.90771303
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.17225752
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.17225752
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.17225752
5NOTCH1_21737748_ChIP-Seq_TLL_Human4.85664134
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66462414
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.63880450
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03323768
9ZNF274_21170338_ChIP-Seq_K562_Hela3.79152698
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56699861
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99559629
12* ETV1_20927104_ChIP-Seq_GIST48_Human2.79468474
13* RBPJ_21746931_ChIP-Seq_IB4_Human2.65802709
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.65575667
15* TBL1_22424771_ChIP-Seq_293T_Human2.46413253
16* NFYB_21822215_ChIP-Seq_K562_Human2.44817247
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41165108
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28025415
19* PHF8_20622853_ChIP-Seq_HELA_Human2.21190335
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.21099011
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.20948336
22MYC_18940864_ChIP-ChIP_HL60_Human2.14787164
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06885909
24* GATA6_21074721_ChIP-Seq_CACO-2_Mouse2.04856647
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98005108
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.95256141
27* GATA6_21074721_ChIP-Seq_CACO-2_Human1.92007307
28* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.86337344
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79410298
30NANOG_20526341_ChIP-Seq_ESCs_Human1.77734661
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75167007
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.74409237
33* HNFA_21074721_ChIP-Seq_CACO-2_Human1.69187843
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57263433
35PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.52924635
36* NFYA_21822215_ChIP-Seq_K562_Human1.46265890
37STAT1_20625510_ChIP-Seq_HELA_Human1.46198849
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42780503
39RAC3_21632823_ChIP-Seq_H3396_Human1.40804563
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38977480
41CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.38171103
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36302466
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35350644
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30250546
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29248585
46E2F7_22180533_ChIP-Seq_HELA_Human1.24685053
47SOX2_21211035_ChIP-Seq_LN229_Human1.22888370
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21263545
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20750178
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17570808
51CTCF_20526341_ChIP-Seq_ESCs_Human1.17206606
52CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15497144
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15365400
54AR_21909140_ChIP-Seq_LNCAP_Human1.13307515
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12574384
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.10878982
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09952325
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09945500
59E2F1_20622854_ChIP-Seq_HELA_Human1.08572937
60TP53_22573176_ChIP-Seq_HFKS_Human1.07576755
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.07278651
62VDR_23849224_ChIP-Seq_CD4+_Human1.07067480
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99754031
64VDR_22108803_ChIP-Seq_LS180_Human0.97787620
65GBX2_23144817_ChIP-Seq_PC3_Human0.97734839
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96792255
67P53_21459846_ChIP-Seq_SAOS-2_Human0.95788662
68NCOR_22424771_ChIP-Seq_293T_Human0.94807865
69ELK1_22589737_ChIP-Seq_MCF10A_Human0.93957079
70FOXH1_21741376_ChIP-Seq_ESCs_Human0.91510482
71OCT4_20526341_ChIP-Seq_ESCs_Human0.90495262
72IRF1_19129219_ChIP-ChIP_H3396_Human0.88124681
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87084758
74NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86567278
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85928904
76FOXH1_21741376_ChIP-Seq_EPCs_Human0.84204232
77STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82386905
78FOXP3_21729870_ChIP-Seq_TREG_Human0.81483310
79SMAD4_21799915_ChIP-Seq_A2780_Human0.81354107
80GATA1_26923725_Chip-Seq_HPCs_Mouse0.80929617
81HOXB7_26014856_ChIP-Seq_BT474_Human0.80595658
82ELK1_19687146_ChIP-ChIP_HELA_Human0.80127432
83RNF2_27304074_Chip-Seq_NSC_Mouse0.78725762
84MYC_18555785_ChIP-Seq_MESCs_Mouse0.78577057
85LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.78188347
86TTF2_22483619_ChIP-Seq_HELA_Human0.78030914
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75322878
88KLF4_19829295_ChIP-Seq_ESCs_Human0.75232326
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74398909
90CTCF_21964334_Chip-Seq_Bcells_Human0.73208956
91GATA3_26560356_Chip-Seq_TH1_Human0.71686539
92GATA3_26560356_Chip-Seq_TH2_Human0.70281090
93MYC_19829295_ChIP-Seq_ESCs_Human0.69432266
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69415242
95E2F4_17652178_ChIP-ChIP_JURKAT_Human0.66846824
96SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.66372890
97NANOG_19829295_ChIP-Seq_ESCs_Human0.65922526
98SOX2_19829295_ChIP-Seq_ESCs_Human0.65922526
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.65700743
100OCT4_19829295_ChIP-Seq_ESCs_Human0.65128088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.30416675
2MP0003718_maternal_effect5.28290061
3MP0009379_abnormal_foot_pigmentation4.18209813
4MP0001986_abnormal_taste_sensitivity4.17517528
5MP0005423_abnormal_somatic_nervous3.96397721
6MP0005394_taste/olfaction_phenotype3.24252098
7MP0005499_abnormal_olfactory_system3.24252098
8MP0005410_abnormal_fertilization3.09774711
9MP0006276_abnormal_autonomic_nervous2.78165608
10MP0003693_abnormal_embryo_hatching2.62025367
11MP0009840_abnormal_foam_cell2.45297202
12MP0008789_abnormal_olfactory_epithelium2.43259118
13MP0002160_abnormal_reproductive_system2.39335627
14MP0001929_abnormal_gametogenesis2.37245794
15MP0002127_abnormal_cardiovascular_syste2.34495250
16MP0008877_abnormal_DNA_methylation2.29773687
17MP0002210_abnormal_sex_determination2.22805803
18MP0005360_urolithiasis2.13657685
19MP0002138_abnormal_hepatobiliary_system2.13166032
20MP0005395_other_phenotype2.12238925
21MP0005647_abnormal_sex_gland2.09019738
22MP0010307_abnormal_tumor_latency2.05206926
23MP0008057_abnormal_DNA_replication2.03756000
24MP0003646_muscle_fatigue2.00585034
25MP0003136_yellow_coat_color1.96669094
26MP0003699_abnormal_female_reproductive1.94177360
27MP0005389_reproductive_system_phenotype1.93547255
28MP0003195_calcinosis1.85099032
29MP0001881_abnormal_mammary_gland1.81172834
30MP0000372_irregular_coat_pigmentation1.79388581
31MP0002277_abnormal_respiratory_mucosa1.75100114
32MP0003077_abnormal_cell_cycle1.73178110
33MP0005646_abnormal_pituitary_gland1.68391388
34MP0010030_abnormal_orbit_morphology1.64653132
35MP0003950_abnormal_plasma_membrane1.63686147
36MP0000653_abnormal_sex_gland1.59494702
37MP0004957_abnormal_blastocyst_morpholog1.58938189
38MP0003111_abnormal_nucleus_morphology1.58488185
39MP0004142_abnormal_muscle_tone1.53053140
40MP0002161_abnormal_fertility/fecundity1.52606591
41MP0003698_abnormal_male_reproductive1.41538875
42MP0003879_abnormal_hair_cell1.39705926
43MP0009333_abnormal_splenocyte_physiolog1.38048800
44MP0001502_abnormal_circadian_rhythm1.37049033
45MP0010094_abnormal_chromosome_stability1.36117932
46MP0002736_abnormal_nociception_after1.34915904
47MP0008058_abnormal_DNA_repair1.34658028
48MP0002254_reproductive_system_inflammat1.26966536
49MP0001968_abnormal_touch/_nociception1.23467498
50MP0001145_abnormal_male_reproductive1.23198667
51MP0001119_abnormal_female_reproductive1.19652862
52MP0010368_abnormal_lymphatic_system1.13512278
53MP0001672_abnormal_embryogenesis/_devel1.05274997
54MP0005380_embryogenesis_phenotype1.05274997
55MP0001293_anophthalmia1.01601990
56MP0001730_embryonic_growth_arrest0.99029257
57MP0002234_abnormal_pharynx_morphology0.98705994
58MP0008932_abnormal_embryonic_tissue0.97140825
59MP0005397_hematopoietic_system_phenotyp0.94666005
60MP0001545_abnormal_hematopoietic_system0.94666005
61MP0004233_abnormal_muscle_weight0.94178399
62MP0002233_abnormal_nose_morphology0.94086575
63MP0000631_abnormal_neuroendocrine_gland0.91886249
64MP0005551_abnormal_eye_electrophysiolog0.90394338
65MP0002139_abnormal_hepatobiliary_system0.90265904
66MP0001919_abnormal_reproductive_system0.88864569
67MP0003121_genomic_imprinting0.88088803
68MP0004215_abnormal_myocardial_fiber0.86144494
69MP0003890_abnormal_embryonic-extraembry0.82463038
70MP0000350_abnormal_cell_proliferation0.80147413
71MP0000627_abnormal_mammary_gland0.80134019
72MP0003119_abnormal_digestive_system0.79726977
73MP0003938_abnormal_ear_development0.76997161
74MP0005085_abnormal_gallbladder_physiolo0.75470771
75MP0002163_abnormal_gland_morphology0.74242978
76MP0003984_embryonic_growth_retardation0.74092444
77MP0001440_abnormal_grooming_behavior0.70564622
78MP0001324_abnormal_eye_pigmentation0.70438110
79MP0002269_muscular_atrophy0.70334258
80MP0002095_abnormal_skin_pigmentation0.69970542
81MP0002088_abnormal_embryonic_growth/wei0.67719023
82MP0001529_abnormal_vocalization0.67282840
83MP0003866_abnormal_defecation0.66345782
84MP0003936_abnormal_reproductive_system0.65515181
85MP0000049_abnormal_middle_ear0.64650044
86MP0004381_abnormal_hair_follicle0.63965854
87MP0005174_abnormal_tail_pigmentation0.63472952
88MP0001666_abnormal_nutrient_absorption0.63299381
89MP0005197_abnormal_uvea_morphology0.61058436
90MP0001984_abnormal_olfaction0.59728915
91MP0002272_abnormal_nervous_system0.58954923
92MP0002873_normal_phenotype0.56335969
93MP0005645_abnormal_hypothalamus_physiol0.56320752
94MP0002169_no_abnormal_phenotype0.55859769
95MP0002102_abnormal_ear_morphology0.54901595
96MP0003186_abnormal_redox_activity0.54571882
97MP0005075_abnormal_melanosome_morpholog0.53845840
98MP0001486_abnormal_startle_reflex0.52369176
99MP0000762_abnormal_tongue_morphology0.52140148
100MP0000569_abnormal_digit_pigmentation0.50861884

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.00910288
2Malnutrition (HP:0004395)6.97346484
3Premature ovarian failure (HP:0008209)5.20044562
4Aplasia/Hypoplasia of the fovea (HP:0008060)4.68824323
5Hypoplasia of the fovea (HP:0007750)4.68824323
6Aplasia/hypoplasia of the uterus (HP:0008684)4.33527876
7Rhinitis (HP:0012384)4.25951784
8Hypercortisolism (HP:0001578)4.18863284
9Infertility (HP:0000789)3.98793870
10Carpal bone hypoplasia (HP:0001498)3.86379386
11Anterior segment dysgenesis (HP:0007700)3.77567054
12Myokymia (HP:0002411)3.72446876
13Birth length less than 3rd percentile (HP:0003561)3.70798406
14Abnormality of the fovea (HP:0000493)3.62305723
15Hypoplasia of the uterus (HP:0000013)3.61313174
16Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.55562144
17Steatorrhea (HP:0002570)3.51694217
18Aplasia/Hypoplasia involving the musculature (HP:0001460)3.25896883
19Aplasia/Hypoplasia of the tibia (HP:0005772)3.20186703
20Attenuation of retinal blood vessels (HP:0007843)3.20138574
21Sensory axonal neuropathy (HP:0003390)3.19263744
22Muscle stiffness (HP:0003552)3.13871427
23Preauricular pit (HP:0004467)3.13326818
24Periauricular skin pits (HP:0100277)3.13326818
25Abnormality of the septum pellucidum (HP:0007375)3.10048820
26Hypophosphatemic rickets (HP:0004912)3.02736694
27Aplasia/Hypoplasia of the macula (HP:0008059)3.00804537
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91555789
29Constricted visual fields (HP:0001133)2.89757155
30Impulsivity (HP:0100710)2.86383381
31Abnormality of abdominal situs (HP:0011620)2.81779482
32Abdominal situs inversus (HP:0003363)2.81779482
33Fat malabsorption (HP:0002630)2.81244281
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.76143107
35Aplasia/Hypoplasia affecting the retina (HP:0008061)2.75716962
36Short tibia (HP:0005736)2.70928158
37Adrenal overactivity (HP:0002717)2.60123762
38Microretrognathia (HP:0000308)2.56151163
39Facial cleft (HP:0002006)2.55738299
40Abnormal ciliary motility (HP:0012262)2.54531333
41Hypergonadotropic hypogonadism (HP:0000815)2.53828879
42Septo-optic dysplasia (HP:0100842)2.52443098
43Bony spicule pigmentary retinopathy (HP:0007737)2.50359676
44Multiple enchondromatosis (HP:0005701)2.48451542
45Dysphonia (HP:0001618)2.45562700
46Limb dystonia (HP:0002451)2.45158635
47Absent septum pellucidum (HP:0001331)2.44593576
48Congenital ichthyosiform erythroderma (HP:0007431)2.36715560
49Aplasia/hypoplasia of the humerus (HP:0006507)2.36461036
50Cone-rod dystrophy (HP:0000548)2.33650110
51Pendular nystagmus (HP:0012043)2.33054638
52Congenital sensorineural hearing impairment (HP:0008527)2.31790408
53Retinal atrophy (HP:0001105)2.31106364
54Central scotoma (HP:0000603)2.28853931
55Cortical visual impairment (HP:0100704)2.22493820
56Cleft eyelid (HP:0000625)2.22437427
57Reticulocytopenia (HP:0001896)2.21924664
58Skin pits (HP:0100276)2.17137609
59Osteomalacia (HP:0002749)2.15730258
60Aplasia of the musculature (HP:0100854)2.15723207
61Gaze-evoked nystagmus (HP:0000640)2.13952655
62Abnormality of the pubic bones (HP:0003172)2.13217915
63Esotropia (HP:0000565)2.12335821
64Macular degeneration (HP:0000608)2.12248247
65Absent radius (HP:0003974)2.11620005
66Abnormality of cells of the erythroid lineage (HP:0012130)2.10836902
67Fibular aplasia (HP:0002990)2.03595744
68Patent foramen ovale (HP:0001655)2.02891866
69Abnormal respiratory motile cilium morphology (HP:0005938)2.00346525
70Abnormal respiratory epithelium morphology (HP:0012253)2.00346525
71Decreased central vision (HP:0007663)1.99736160
72Glossoptosis (HP:0000162)1.99331496
73Nausea (HP:0002018)1.99168904
74Aplasia involving forearm bones (HP:0009822)1.98796754
75Absent forearm bone (HP:0003953)1.98796754
76Midline defect of the nose (HP:0004122)1.98260309
77Progressive cerebellar ataxia (HP:0002073)1.97665607
78Anhidrosis (HP:0000970)1.96804486
79Decreased circulating renin level (HP:0003351)1.95879296
80Fused cervical vertebrae (HP:0002949)1.95420638
81Atresia of the external auditory canal (HP:0000413)1.94085901
82Clumsiness (HP:0002312)1.93750534
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.90800254
84Selective tooth agenesis (HP:0001592)1.90501997
85Progressive sensorineural hearing impairment (HP:0000408)1.89958657
86Abnormal number of erythroid precursors (HP:0012131)1.89785990
87Delayed CNS myelination (HP:0002188)1.87730575
88Abnormal respiratory motile cilium physiology (HP:0012261)1.87577777
89Absent thumb (HP:0009777)1.87261188
90Cranial hyperostosis (HP:0004437)1.86361582
91Concave nail (HP:0001598)1.86339923
92Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85479718
93Impaired proprioception (HP:0010831)1.84672045
94Progressive hearing impairment (HP:0001730)1.84492773
95Pancreatic cysts (HP:0001737)1.83198337
96Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81313865
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.80512696
98Absent/shortened dynein arms (HP:0200106)1.80512696
99Progressive inability to walk (HP:0002505)1.79220592
100Chronic sinusitis (HP:0011109)1.78527596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.93397007
2BUB14.15336064
3CDK194.02733031
4LATS23.99629901
5SRPK13.47824215
6NEK63.44362127
7BRSK23.11470128
8TRIM283.09664676
9STK162.69496446
10FRK2.45412950
11BRSK12.36092588
12MAP3K92.16577205
13ZAK2.15596646
14MARK31.89124124
15PLK11.80934536
16EIF2AK31.65113074
17TLK11.61603854
18ACVR1B1.59604550
19MELK1.51562862
20WNK11.51290321
21MAP3K51.50015822
22NEK21.43521051
23PRKCI1.41777622
24TAOK31.39507684
25PKN11.39454201
26CDK71.39320718
27NTRK31.38261717
28AURKB1.35837103
29PLK31.28930890
30AURKA1.28633413
31STK31.28143401
32NME11.17377098
33DYRK31.15927293
34GSK3A1.14060007
35INSRR1.08542790
36STK240.97701716
37CHEK10.97646817
38WNK30.97547956
39CDK90.96357143
40CSNK1E0.92446008
41CDC70.92400464
42PIM10.90053704
43LRRK20.89614165
44KDR0.89422043
45PDK20.86779815
46CHEK20.85089317
47ADRBK20.74392681
48PIM20.68718161
49PBK0.66353093
50VRK10.64295131
51PAK10.64215046
52CSNK2A10.62919478
53PIK3CG0.61759789
54CSNK2A20.60904775
55CDK20.58649812
56BMPR1B0.58352471
57AKT20.56484122
58WEE10.56285879
59PLK40.55013309
60RAF10.53917961
61TTK0.51471131
62ATR0.51299120
63LATS10.50736565
64TNK20.46619247
65STK40.45937446
66CDK10.45577270
67VRK20.44300109
68PAK20.43549705
69CDK120.42819701
70NUAK10.42790441
71CAMK10.40711859
72MTOR0.40275543
73TGFBR10.40235334
74PDK10.38517949
75MAPK110.38383960
76ADRBK10.37333560
77PRKG10.36833321
78ARAF0.36798635
79GRK50.35669061
80CSNK1D0.35190133
81DMPK0.31465597
82MAP3K130.30097681
83GSK3B0.29792642
84STK38L0.29582157
85CDK11A0.29492637
86OXSR10.27934873
87PRKCG0.26655180
88ATM0.25517953
89MAPK130.25105727
90GRK10.24763337
91PRKCE0.24329581
92MAPK10.23414053
93CSNK1A10.20458581
94PRKACA0.19524058
95CSNK1G10.18968609
96NTRK20.18445998
97CAMK2A0.17382033
98STK390.16876364
99PRKD10.16747904
100MAPK90.16737021

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030226.42258470
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92196132
3Ribosome_Homo sapiens_hsa030103.78569628
4RNA polymerase_Homo sapiens_hsa030203.48985866
5mRNA surveillance pathway_Homo sapiens_hsa030153.26062856
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.16192235
7Taste transduction_Homo sapiens_hsa047423.12670498
8Ovarian steroidogenesis_Homo sapiens_hsa049133.05879740
9Cell cycle_Homo sapiens_hsa041103.01894734
10Regulation of autophagy_Homo sapiens_hsa041402.84776372
11Folate biosynthesis_Homo sapiens_hsa007902.73078067
12Oocyte meiosis_Homo sapiens_hsa041142.31733658
13RNA transport_Homo sapiens_hsa030132.24312213
14p53 signaling pathway_Homo sapiens_hsa041152.24147910
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.19710550
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00222136
17Spliceosome_Homo sapiens_hsa030401.90507077
18Olfactory transduction_Homo sapiens_hsa047401.60014070
19Fatty acid biosynthesis_Homo sapiens_hsa000611.54813715
20ABC transporters_Homo sapiens_hsa020101.49296920
21Cardiac muscle contraction_Homo sapiens_hsa042601.27668952
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.21216711
23Sulfur metabolism_Homo sapiens_hsa009201.11345903
24Homologous recombination_Homo sapiens_hsa034401.11145874
25Serotonergic synapse_Homo sapiens_hsa047261.06892600
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04975629
27Viral carcinogenesis_Homo sapiens_hsa052031.02623306
28RNA degradation_Homo sapiens_hsa030181.02380540
29Pyrimidine metabolism_Homo sapiens_hsa002401.01317332
30Fanconi anemia pathway_Homo sapiens_hsa034600.96299955
31Mismatch repair_Homo sapiens_hsa034300.96180579
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.94536700
33Caffeine metabolism_Homo sapiens_hsa002320.94504920
34Huntingtons disease_Homo sapiens_hsa050160.94471441
35Base excision repair_Homo sapiens_hsa034100.92114589
36Nicotine addiction_Homo sapiens_hsa050330.91764031
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87569929
38Morphine addiction_Homo sapiens_hsa050320.84280854
39Nucleotide excision repair_Homo sapiens_hsa034200.80796427
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80310679
41Purine metabolism_Homo sapiens_hsa002300.74518947
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72300734
43Dorso-ventral axis formation_Homo sapiens_hsa043200.70673604
44Epstein-Barr virus infection_Homo sapiens_hsa051690.69814516
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68912176
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64950165
47Fatty acid elongation_Homo sapiens_hsa000620.60708522
48MicroRNAs in cancer_Homo sapiens_hsa052060.60191430
49DNA replication_Homo sapiens_hsa030300.59748108
50Histidine metabolism_Homo sapiens_hsa003400.56624866
51Insulin secretion_Homo sapiens_hsa049110.55499563
52GABAergic synapse_Homo sapiens_hsa047270.52862955
53Herpes simplex infection_Homo sapiens_hsa051680.52744701
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51932315
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50767349
56Bile secretion_Homo sapiens_hsa049760.48373626
57Linoleic acid metabolism_Homo sapiens_hsa005910.47261749
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41945512
59Parkinsons disease_Homo sapiens_hsa050120.40764016
60Wnt signaling pathway_Homo sapiens_hsa043100.40359335
61Steroid biosynthesis_Homo sapiens_hsa001000.37529077
62Inositol phosphate metabolism_Homo sapiens_hsa005620.37314572
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.36714767
64Protein digestion and absorption_Homo sapiens_hsa049740.35888178
65Mineral absorption_Homo sapiens_hsa049780.33786546
66Calcium signaling pathway_Homo sapiens_hsa040200.33746263
67Small cell lung cancer_Homo sapiens_hsa052220.33532521
68Oxytocin signaling pathway_Homo sapiens_hsa049210.33329936
69Hepatitis B_Homo sapiens_hsa051610.32968089
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31807249
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30521997
72Arginine and proline metabolism_Homo sapiens_hsa003300.30172557
73Circadian entrainment_Homo sapiens_hsa047130.29737637
74Phototransduction_Homo sapiens_hsa047440.28365001
75Retinol metabolism_Homo sapiens_hsa008300.28271461
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.27315166
77AMPK signaling pathway_Homo sapiens_hsa041520.27233915
78TGF-beta signaling pathway_Homo sapiens_hsa043500.25301901
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24163504
80Systemic lupus erythematosus_Homo sapiens_hsa053220.23944235
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.22972838
82Salivary secretion_Homo sapiens_hsa049700.18547981
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17965783
84Pancreatic secretion_Homo sapiens_hsa049720.17895091
85Amphetamine addiction_Homo sapiens_hsa050310.17037327
86Long-term depression_Homo sapiens_hsa047300.14960323
87Acute myeloid leukemia_Homo sapiens_hsa052210.14871544
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14201228
89Nitrogen metabolism_Homo sapiens_hsa009100.13369991
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13129992
91Gastric acid secretion_Homo sapiens_hsa049710.12462299
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10852172
93Glutamatergic synapse_Homo sapiens_hsa047240.10732965
94FoxO signaling pathway_Homo sapiens_hsa040680.10691866
95Gap junction_Homo sapiens_hsa045400.10143934
96Arachidonic acid metabolism_Homo sapiens_hsa005900.10045694
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10027541
98Alcoholism_Homo sapiens_hsa050340.09807046
99Metabolic pathways_Homo sapiens_hsa011000.08849535
100Cholinergic synapse_Homo sapiens_hsa047250.08658646

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