PRAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.57572631
2acrosome reaction (GO:0007340)7.29176613
3sperm motility (GO:0030317)7.05807095
4fusion of sperm to egg plasma membrane (GO:0007342)6.26491388
5mesenchymal cell differentiation involved in renal system development (GO:2001012)6.18158255
6mesenchymal cell differentiation involved in kidney development (GO:0072161)6.18158255
7sperm capacitation (GO:0048240)6.06079155
8DNA packaging (GO:0006323)6.00874185
9chromosome condensation (GO:0030261)5.91312370
10binding of sperm to zona pellucida (GO:0007339)5.76381343
11spermatid development (GO:0007286)5.69015591
12spermatid nucleus differentiation (GO:0007289)5.67114859
13sperm-egg recognition (GO:0035036)5.41176954
14plasma membrane fusion (GO:0045026)5.27757811
15regulation of mesoderm development (GO:2000380)5.07853594
16regulation of somitogenesis (GO:0014807)5.05220622
17branching involved in prostate gland morphogenesis (GO:0060442)4.97403349
18single strand break repair (GO:0000012)4.93388899
19positive regulation of endothelial cell differentiation (GO:0045603)4.75098562
20multicellular organism reproduction (GO:0032504)4.56967844
21cell-cell recognition (GO:0009988)4.49492794
22cilium or flagellum-dependent cell motility (GO:0001539)4.39975350
23reproduction (GO:0000003)4.21531214
24somite rostral/caudal axis specification (GO:0032525)4.12383105
25artery development (GO:0060840)4.09321053
26microtubule depolymerization (GO:0007019)3.95404319
27sexual reproduction (GO:0019953)3.87463752
28rRNA methylation (GO:0031167)3.87376479
29spermatogenesis (GO:0007283)3.86702951
30male gamete generation (GO:0048232)3.84783539
31regulation of endothelial cell differentiation (GO:0045601)3.82209128
32prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.80136142
33pharyngeal system development (GO:0060037)3.77329494
34histone exchange (GO:0043486)3.73551245
35calcium ion-dependent exocytosis (GO:0017156)3.69084217
36protein polyglutamylation (GO:0018095)3.68974940
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65224538
38cell migration involved in gastrulation (GO:0042074)3.64822950
39muscle cell fate commitment (GO:0042693)3.61939413
40rRNA modification (GO:0000154)3.60898845
41gamete generation (GO:0007276)3.59529639
42regulation of transcription involved in cell fate commitment (GO:0060850)3.55297266
43receptor recycling (GO:0001881)3.54432365
44microtubule severing (GO:0051013)3.47725304
45germ cell development (GO:0007281)3.46859687
46negative regulation of inclusion body assembly (GO:0090084)3.44108684
47single fertilization (GO:0007338)3.40133244
48polyamine biosynthetic process (GO:0006596)3.35975360
49microtubule polymerization or depolymerization (GO:0031109)3.33756230
50regulation of cardioblast differentiation (GO:0051890)3.33715452
51axonemal dynein complex assembly (GO:0070286)3.32579915
52coronary vasculature morphogenesis (GO:0060977)3.30607303
53membrane protein ectodomain proteolysis (GO:0006509)3.25928600
54cellular process involved in reproduction in multicellular organism (GO:0022412)3.24705453
55muscle organ morphogenesis (GO:0048644)3.20881355
56anterior/posterior axis specification (GO:0009948)3.18593775
57phosphatidylethanolamine biosynthetic process (GO:0006646)3.16978453
58endoderm formation (GO:0001706)3.14665916
59chromatin silencing (GO:0006342)3.12900354
60tooth mineralization (GO:0034505)3.07924497
61embryonic skeletal joint morphogenesis (GO:0060272)3.06325615
62outflow tract septum morphogenesis (GO:0003148)3.05469628
63cellular ketone body metabolic process (GO:0046950)3.04830876
64multicellular organismal movement (GO:0050879)3.03285461
65musculoskeletal movement (GO:0050881)3.03285461
66UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01360802
67nucleosome disassembly (GO:0006337)2.98879801
68protein-DNA complex disassembly (GO:0032986)2.98879801
69multicellular organismal reproductive process (GO:0048609)2.96530073
70negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.95105059
71protein targeting to Golgi (GO:0000042)2.93005248
72male meiosis I (GO:0007141)2.90556228
73regulation of secondary heart field cardioblast proliferation (GO:0003266)2.90449666
74regulation of cardioblast proliferation (GO:0003264)2.90449666
75peristalsis (GO:0030432)2.85912855
76endothelial cell proliferation (GO:0001935)2.82833252
77phosphatidylethanolamine metabolic process (GO:0046337)2.82401654
78retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80866370
79urinary tract smooth muscle contraction (GO:0014848)2.77363001
80positive regulation of cardiac muscle cell differentiation (GO:2000727)2.76522306
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.74465444
82establishment of protein localization to Golgi (GO:0072600)2.73224308
83ketone body metabolic process (GO:1902224)2.70071195
84cranial nerve morphogenesis (GO:0021602)2.69667543
85fertilization (GO:0009566)2.68723585
86retrograde transport, vesicle recycling within Golgi (GO:0000301)2.68574256
87glycerol ether metabolic process (GO:0006662)2.65659408
88regulation of protein polyubiquitination (GO:1902914)2.65622100
89negative regulation of DNA repair (GO:0045738)2.65047495
90piRNA metabolic process (GO:0034587)2.64469464
91outer ear morphogenesis (GO:0042473)2.62468203
92negative regulation of embryonic development (GO:0045992)2.61896423
93cellular response to BMP stimulus (GO:0071773)2.61849367
94response to BMP (GO:0071772)2.61849367
95cardiocyte differentiation (GO:0035051)2.60429218
96embryonic axis specification (GO:0000578)2.58829757
97cardiac muscle cell differentiation (GO:0055007)2.58110324
98anterior/posterior axis specification, embryo (GO:0008595)2.55233364
99motile cilium assembly (GO:0044458)2.54445154
100phospholipid scrambling (GO:0017121)2.54428509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.42042793
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.39436725
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.62138140
4VDR_22108803_ChIP-Seq_LS180_Human3.09382271
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88884682
6AR_21909140_ChIP-Seq_LNCAP_Human2.84606705
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35305004
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15475232
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.01131073
10EED_16625203_ChIP-ChIP_MESCs_Mouse1.96447882
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.77681395
12CBP_20019798_ChIP-Seq_JUKART_Human1.77681395
13AR_21572438_ChIP-Seq_LNCaP_Human1.68649654
14ERA_21632823_ChIP-Seq_H3396_Human1.67208248
15ERG_20517297_ChIP-Seq_VCAP_Human1.66451215
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63544657
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62581933
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62364289
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60784076
20FUS_26573619_Chip-Seq_HEK293_Human1.56318728
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.54604738
22YY1_22570637_ChIP-Seq_MALME-3M_Human1.49995500
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.48822909
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48477733
25SMAD4_21741376_ChIP-Seq_HESCs_Human1.43792680
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.41666252
27RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39367295
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39022583
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.37851936
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37432890
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.34020393
32E2F1_17053090_ChIP-ChIP_MCF-7_Human1.33120806
33OCT4_20526341_ChIP-Seq_ESCs_Human1.32290286
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30917735
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30691939
36CTCF_27219007_Chip-Seq_Bcells_Human1.28019515
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.27452415
38CHD1_26751641_Chip-Seq_LNCaP_Human1.26496397
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25980521
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25817640
41RAC3_21632823_ChIP-Seq_H3396_Human1.25724480
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.21680101
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21227159
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21227159
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18236292
46E2F1_20622854_ChIP-Seq_HELA_Human1.18011759
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.17054328
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16650299
49FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15867683
50NANOG_20526341_ChIP-Seq_ESCs_Human1.15020985
51EZH2_22144423_ChIP-Seq_EOC_Human1.14759849
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14738622
53CSB_26484114_Chip-Seq_FIBROBLAST_Human1.11838305
54PHF8_20622854_ChIP-Seq_HELA_Human1.11483064
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10782615
56TTF2_22483619_ChIP-Seq_HELA_Human1.09798376
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09363766
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08370110
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06831575
60P68_20966046_ChIP-Seq_HELA_Human1.06041198
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04594245
62BCL6_27268052_Chip-Seq_Bcells_Human1.04266308
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03807134
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03550722
65AR_25329375_ChIP-Seq_VCAP_Human1.02736301
66RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00495608
67P300_27268052_Chip-Seq_Bcells_Human1.00476808
68BCOR_27268052_Chip-Seq_Bcells_Human0.99814767
69RARA_24833708_ChIP-Seq_LIVER_Mouse0.99091706
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98690640
71XRN2_22483619_ChIP-Seq_HELA_Human0.97697776
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97694366
73FOXP1_21924763_ChIP-Seq_HESCs_Human0.97042249
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96968230
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96968230
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96968230
77ELF5_23300383_ChIP-Seq_T47D_Human0.96841709
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96824837
79LXR_22292898_ChIP-Seq_THP-1_Human0.96801487
80P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96511548
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96137614
82CTCF_20526341_ChIP-Seq_ESCs_Human0.96045897
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95200249
84P300_19829295_ChIP-Seq_ESCs_Human0.94242338
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94240037
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92755073
87TP53_20018659_ChIP-ChIP_R1E_Mouse0.92462411
88SMC4_20622854_ChIP-Seq_HELA_Human0.92410739
89FOXA1_25552417_ChIP-Seq_VCAP_Human0.91964866
90P53_21459846_ChIP-Seq_SAOS-2_Human0.91396339
91UBF1/2_26484160_Chip-Seq_HMECs_Human0.90302516
92RUNX2_22187159_ChIP-Seq_PCA_Human0.90070569
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89532283
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89188980
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.87164658
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.86655869
97HOXB7_26014856_ChIP-Seq_BT474_Human0.86617670
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86543130
99TP53_18474530_ChIP-ChIP_U2OS_Human0.85810056
100NANOG_19829295_ChIP-Seq_ESCs_Human0.85042193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.48430901
2MP0001879_abnormal_lymphatic_vessel3.74894560
3MP0010368_abnormal_lymphatic_system3.12413306
4MP0002234_abnormal_pharynx_morphology3.05726254
5MP0005670_abnormal_white_adipose3.03363450
6MP0003698_abnormal_male_reproductive2.70011904
7MP0003890_abnormal_embryonic-extraembry2.49059406
8MP0001929_abnormal_gametogenesis2.37805527
9MP0004858_abnormal_nervous_system2.12763492
10MP0009384_cardiac_valve_regurgitation2.12711665
11MP0000678_abnormal_parathyroid_gland2.07694786
12MP0003119_abnormal_digestive_system1.88420894
13MP0004145_abnormal_muscle_electrophysio1.83174942
14MP0001348_abnormal_lacrimal_gland1.82260141
15MP0001485_abnormal_pinna_reflex1.81078719
16MP0002127_abnormal_cardiovascular_syste1.77269679
17MP0000534_abnormal_ureter_morphology1.76849480
18MP0003567_abnormal_fetal_cardiomyocyte1.72591498
19MP0002009_preneoplasia1.71438523
20MP0000537_abnormal_urethra_morphology1.69049333
21MP0010030_abnormal_orbit_morphology1.66296804
22MP0003693_abnormal_embryo_hatching1.64675958
23MP0002249_abnormal_larynx_morphology1.64209602
24MP0005379_endocrine/exocrine_gland_phen1.56471566
25MP0002163_abnormal_gland_morphology1.54798016
26MP0000613_abnormal_salivary_gland1.53734814
27MP0000049_abnormal_middle_ear1.48146612
28MP0005367_renal/urinary_system_phenotyp1.47784693
29MP0000516_abnormal_urinary_system1.47784693
30MP0002822_catalepsy1.46509844
31MP0002210_abnormal_sex_determination1.46475580
32MP0002161_abnormal_fertility/fecundity1.46113590
33MP0003315_abnormal_perineum_morphology1.43797449
34MP0005377_hearing/vestibular/ear_phenot1.41959677
35MP0003878_abnormal_ear_physiology1.41959677
36MP0002932_abnormal_joint_morphology1.39925370
37MP0004957_abnormal_blastocyst_morpholog1.35406515
38MP0009053_abnormal_anal_canal1.33595153
39MP0001145_abnormal_male_reproductive1.33441316
40MP0001293_anophthalmia1.30970335
41MP0005647_abnormal_sex_gland1.23651612
42MP0003279_aneurysm1.23575262
43MP0000653_abnormal_sex_gland1.22327149
44MP0003385_abnormal_body_wall1.22055687
45MP0002160_abnormal_reproductive_system1.19247494
46MP0009250_abnormal_appendicular_skeleto1.15586012
47MP0004272_abnormal_basement_membrane1.09989657
48MP0002282_abnormal_trachea_morphology1.09989262
49MP0000762_abnormal_tongue_morphology1.09258835
50MP0003935_abnormal_craniofacial_develop1.08856894
51MP0005409_darkened_coat_color1.07950489
52MP0000163_abnormal_cartilage_morphology1.07046705
53MP0003718_maternal_effect1.07015520
54MP0003077_abnormal_cell_cycle1.07010905
55MP0002132_abnormal_respiratory_system1.06315984
56MP0005380_embryogenesis_phenotype1.05120063
57MP0001672_abnormal_embryogenesis/_devel1.05120063
58MP0004264_abnormal_extraembryonic_tissu1.04641740
59MP0003011_delayed_dark_adaptation1.02756291
60MP0005167_abnormal_blood-brain_barrier1.02488002
61MP0004233_abnormal_muscle_weight1.01427824
62MP0000733_abnormal_muscle_development1.00694047
63MP0009697_abnormal_copulation0.99389467
64MP0005257_abnormal_intraocular_pressure0.98523333
65MP0002084_abnormal_developmental_patter0.95854383
66MP0004085_abnormal_heartbeat0.94890067
67MP0002085_abnormal_embryonic_tissue0.93497858
68MP0002138_abnormal_hepatobiliary_system0.91971676
69MP0004036_abnormal_muscle_relaxation0.91443594
70MP0001730_embryonic_growth_arrest0.89012457
71MP0002102_abnormal_ear_morphology0.88795805
72MP0005451_abnormal_body_composition0.86428275
73MP0005623_abnormal_meninges_morphology0.86186520
74MP0003942_abnormal_urinary_system0.85485907
75MP0001486_abnormal_startle_reflex0.84958386
76MP0003937_abnormal_limbs/digits/tail_de0.82971283
77MP0002116_abnormal_craniofacial_bone0.82851974
78MP0003705_abnormal_hypodermis_morpholog0.81987770
79MP0004742_abnormal_vestibular_system0.81817471
80MP0001544_abnormal_cardiovascular_syste0.81129846
81MP0005385_cardiovascular_system_phenoty0.81129846
82MP0003936_abnormal_reproductive_system0.80864730
83MP0003984_embryonic_growth_retardation0.80484891
84MP0005423_abnormal_somatic_nervous0.80163791
85MP0006138_congestive_heart_failure0.78907685
86MP0001727_abnormal_embryo_implantation0.78011314
87MP0002108_abnormal_muscle_morphology0.77471248
88MP0000428_abnormal_craniofacial_morphol0.77142862
89MP0008004_abnormal_stomach_pH0.77084926
90MP0002114_abnormal_axial_skeleton0.77002869
91MP0000767_abnormal_smooth_muscle0.76200511
92MP0000026_abnormal_inner_ear0.76111061
93MP0002111_abnormal_tail_morphology0.76025654
94MP0001286_abnormal_eye_development0.75211056
95MP0001968_abnormal_touch/_nociception0.74244798
96MP0003755_abnormal_palate_morphology0.73902805
97MP0002088_abnormal_embryonic_growth/wei0.73159398
98MP0003123_paternal_imprinting0.72699528
99MP0002796_impaired_skin_barrier0.70083076
100MP0002925_abnormal_cardiovascular_devel0.69874254

Predicted human phenotypes

RankGene SetZ-score
1Anal stenosis (HP:0002025)4.77932525
2Fibular aplasia (HP:0002990)4.74249607
3Azoospermia (HP:0000027)4.44490743
4Abnormality of the lumbar spine (HP:0100712)3.88939637
5Abnormal spermatogenesis (HP:0008669)3.77663322
6Congenital malformation of the right heart (HP:0011723)3.57190162
7Double outlet right ventricle (HP:0001719)3.57190162
8Asymmetry of the thorax (HP:0001555)3.48146537
9Subcapsular cataract (HP:0000523)3.36674012
10Thoracic kyphosis (HP:0002942)3.21602576
11Severe visual impairment (HP:0001141)3.16059574
12Bifid uvula (HP:0000193)3.11604534
13Periauricular skin pits (HP:0100277)2.97123138
14Preauricular pit (HP:0004467)2.97123138
15Abnormality of the parathyroid morphology (HP:0011766)2.91978574
16Abnormality of the aortic arch (HP:0012303)2.90832025
17Hyperkalemia (HP:0002153)2.90336333
18Amelogenesis imperfecta (HP:0000705)2.88249849
19Anomalous pulmonary venous return (HP:0010772)2.87695859
20Unilateral renal agenesis (HP:0000122)2.87178080
21Gonadotropin excess (HP:0000837)2.86927073
22Bony spicule pigmentary retinopathy (HP:0007737)2.79219901
23Abnormality of the pulmonary veins (HP:0011718)2.77311949
24Resting tremor (HP:0002322)2.72487316
25Overfolded helix (HP:0000396)2.72014060
26Nasal speech (HP:0001611)2.68129543
27Rough bone trabeculation (HP:0100670)2.63927949
28Absent/shortened dynein arms (HP:0200106)2.61493860
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.61493860
30Abnormality of the fetal cardiovascular system (HP:0010948)2.61084652
31Abnormal umbilical cord blood vessels (HP:0011403)2.61084652
32Single umbilical artery (HP:0001195)2.61084652
33Asymmetric septal hypertrophy (HP:0001670)2.58656054
34Flat acetabular roof (HP:0003180)2.56412092
35Glossoptosis (HP:0000162)2.55548134
36Hypoplastic left heart (HP:0004383)2.55531723
37Abnormal ventriculo-arterial connection (HP:0011563)2.52432968
38Transposition of the great arteries (HP:0001669)2.52432968
39Abnormal connection of the cardiac segments (HP:0011545)2.52432968
40Abnormally folded helix (HP:0008544)2.49403725
41Abnormal trabecular bone morphology (HP:0100671)2.48289710
42Tubulointerstitial nephritis (HP:0001970)2.43044194
43Bell-shaped thorax (HP:0001591)2.39738712
44Pigmentary retinal degeneration (HP:0001146)2.37577979
45Hypoplastic heart (HP:0001961)2.37260706
46Abnormal tarsal ossification (HP:0008369)2.32499008
47Broad ribs (HP:0000885)2.31959728
48Hypoplastic ischia (HP:0003175)2.30269411
49Attenuation of retinal blood vessels (HP:0007843)2.29748671
50Oral leukoplakia (HP:0002745)2.29681165
51Natal tooth (HP:0000695)2.28955565
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27724022
53Skin pits (HP:0100276)2.26868955
54Partial agenesis of the corpus callosum (HP:0001338)2.26315874
55Abnormality of the ischium (HP:0003174)2.24007839
56Short 1st metacarpal (HP:0010034)2.20889945
57Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.20889945
58Renal cortical cysts (HP:0000803)2.20182358
59Abnormality of the thoracic spine (HP:0100711)2.17922223
60Tinnitus (HP:0000360)2.16010815
61Myelomeningocele (HP:0002475)2.14455823
62Abnormality of the 1st metacarpal (HP:0010009)2.11666007
63Spontaneous abortion (HP:0005268)2.10154651
64Advanced eruption of teeth (HP:0006288)2.09620443
65Abnormalities of placenta or umbilical cord (HP:0001194)2.09055050
66Esophageal varix (HP:0002040)2.08170679
67Sensory axonal neuropathy (HP:0003390)2.07595293
68Anal atresia (HP:0002023)2.06142248
69Short phalanx of the thumb (HP:0009660)2.04611103
70Generalized aminoaciduria (HP:0002909)2.02008865
71Hepatocellular necrosis (HP:0001404)1.96730409
72Abnormality of the umbilical cord (HP:0010881)1.96534823
73Polar cataract (HP:0010696)1.96033000
74Infertility (HP:0000789)1.95268401
75Abnormal pancreas size (HP:0012094)1.94672038
76Potter facies (HP:0002009)1.94320800
77Facial shape deformation (HP:0011334)1.94320800
78Flattened epiphyses (HP:0003071)1.93605830
79Bulbous nose (HP:0000414)1.93072893
80Abnormal ciliary motility (HP:0012262)1.92479961
81Abnormal respiratory motile cilium physiology (HP:0012261)1.90572451
82Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.88885206
83Truncus arteriosus (HP:0001660)1.87203319
84Calf muscle hypertrophy (HP:0008981)1.86410537
85Nephronophthisis (HP:0000090)1.85563733
86Abnormality of the odontoid process (HP:0003310)1.84813936
87Woolly hair (HP:0002224)1.84194368
88Abdominal situs inversus (HP:0003363)1.82569556
89Abnormality of abdominal situs (HP:0011620)1.82569556
90Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82134954
91Multiple enchondromatosis (HP:0005701)1.81403096
92Testicular atrophy (HP:0000029)1.81050170
93Aplasia/hypoplasia of the humerus (HP:0006507)1.80722276
94Short middle phalanx of the 5th finger (HP:0004220)1.80592937
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.79029286
96Abnormality of the phalanges of the hallux (HP:0010057)1.78608173
97Aortic regurgitation (HP:0001659)1.78164546
98Muscle hypertrophy of the lower extremities (HP:0008968)1.77624276
99Abnormal respiratory motile cilium morphology (HP:0005938)1.77368213
100Abnormal respiratory epithelium morphology (HP:0012253)1.77368213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD35.22160723
2PLK45.16048549
3TIE13.92610403
4TESK13.73721994
5AKT33.38420530
6BMPR1B3.10491585
7DDR22.77069727
8ACVR1B2.44459684
9CAMK1G2.41381756
10NME22.36803817
11STK382.31871978
12EPHA22.27496667
13CAMK1D2.14988709
14MAP4K21.65703610
15ARAF1.64381519
16FER1.61041660
17PLK21.57330338
18ERBB41.57178636
19TNK21.54987714
20PBK1.49457588
21PKN21.46840649
22STK391.31751114
23BUB11.20129419
24EEF2K1.13817268
25TGFBR11.10277934
26TEC1.10059309
27BRSK21.07643838
28TRIM281.05926049
29PIM21.00569834
30GRK10.99050084
31VRK20.97642642
32PNCK0.97528585
33CDK70.92909001
34BRD40.92649479
35PTK20.91809625
36STK160.91684707
37CDK30.89946251
38TAOK10.86733104
39PRKD20.86118591
40INSRR0.85675070
41TESK20.81021543
42BRSK10.79328093
43BRAF0.78796925
44DYRK30.78575897
45MAPK150.77348126
46DYRK1B0.75650861
47PRKAA20.74968925
48RPS6KA20.74717678
49MST1R0.73499358
50IRAK30.72308959
51DAPK20.71445838
52RPS6KL10.70149715
53RPS6KC10.70149715
54STK38L0.69490398
55SRPK10.68505845
56WNK40.68443505
57PDPK10.67880848
58SGK4940.65321485
59SGK2230.65321485
60RPS6KA60.64843710
61MAP3K80.64709728
62AKT20.63035784
63DAPK30.63002107
64LATS20.61096633
65TRIB30.60678076
66MET0.59419007
67CDK80.58526836
68LMTK20.58281911
69KDR0.57937471
70MAPKAPK30.57624639
71MAP3K30.57395893
72FLT30.56550596
73PAK40.56387822
74SMG10.55350874
75PDK10.54987456
76PAK20.53624476
77CAMK40.52863614
78RPS6KB20.52253585
79MTOR0.49739506
80ILK0.49440029
81MUSK0.49219159
82TGFBR20.46732297
83BLK0.46445961
84NUAK10.45330032
85AURKA0.45104806
86PTK2B0.44197659
87RPS6KA40.44042631
88LATS10.43256670
89NEK10.43243906
90EPHB20.41823872
91RAF10.41134945
92ERBB30.40281102
93MKNK20.39491939
94SGK20.38268184
95OBSCN0.37863564
96RPS6KA50.35585855
97MAP3K110.35325139
98MAP2K10.33763446
99PIK3CG0.33205781
100PDK20.31600884

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.13852154
2Fatty acid biosynthesis_Homo sapiens_hsa000614.13354787
3Selenocompound metabolism_Homo sapiens_hsa004504.09209207
4Ribosome_Homo sapiens_hsa030102.69221491
5Pyruvate metabolism_Homo sapiens_hsa006202.58185945
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42677855
7Fatty acid metabolism_Homo sapiens_hsa012122.07149425
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99430099
9Huntingtons disease_Homo sapiens_hsa050161.97139969
10Olfactory transduction_Homo sapiens_hsa047401.84877925
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84036117
12Proteasome_Homo sapiens_hsa030501.81241797
13RNA transport_Homo sapiens_hsa030131.81115303
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80622286
15Basal transcription factors_Homo sapiens_hsa030221.69043667
16Homologous recombination_Homo sapiens_hsa034401.51839556
17Parkinsons disease_Homo sapiens_hsa050121.49383133
18Arginine and proline metabolism_Homo sapiens_hsa003301.43747531
19Hedgehog signaling pathway_Homo sapiens_hsa043401.43486060
20Caffeine metabolism_Homo sapiens_hsa002321.42731601
21RNA polymerase_Homo sapiens_hsa030201.40815073
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29568844
23Fatty acid degradation_Homo sapiens_hsa000711.28285892
24Basal cell carcinoma_Homo sapiens_hsa052171.27617918
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25309025
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24530066
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24038281
28Sulfur relay system_Homo sapiens_hsa041221.22476684
29Propanoate metabolism_Homo sapiens_hsa006401.21724933
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19524611
31Peroxisome_Homo sapiens_hsa041461.19002875
32Pyrimidine metabolism_Homo sapiens_hsa002401.17391870
33Taste transduction_Homo sapiens_hsa047421.13626790
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13612006
35Oxidative phosphorylation_Homo sapiens_hsa001901.13253498
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13081748
37Renin-angiotensin system_Homo sapiens_hsa046141.12913169
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12437980
39Butanoate metabolism_Homo sapiens_hsa006501.08452075
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.08184165
41Purine metabolism_Homo sapiens_hsa002301.06599086
42Phenylalanine metabolism_Homo sapiens_hsa003601.02964866
43Spliceosome_Homo sapiens_hsa030400.94814981
44Steroid biosynthesis_Homo sapiens_hsa001000.93676103
45Wnt signaling pathway_Homo sapiens_hsa043100.92887557
46Cardiac muscle contraction_Homo sapiens_hsa042600.89482846
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87723485
48Alzheimers disease_Homo sapiens_hsa050100.87041855
49TGF-beta signaling pathway_Homo sapiens_hsa043500.86907663
50Hippo signaling pathway_Homo sapiens_hsa043900.85136256
51Salivary secretion_Homo sapiens_hsa049700.79913359
52Renin secretion_Homo sapiens_hsa049240.75322467
53RNA degradation_Homo sapiens_hsa030180.75160870
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.74718322
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72328060
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71461304
57Lysine degradation_Homo sapiens_hsa003100.71431850
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.69456170
59Oocyte meiosis_Homo sapiens_hsa041140.69026964
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68071733
61Vitamin digestion and absorption_Homo sapiens_hsa049770.63933081
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63288568
63Carbon metabolism_Homo sapiens_hsa012000.62771407
64cAMP signaling pathway_Homo sapiens_hsa040240.62448897
65Tight junction_Homo sapiens_hsa045300.61932993
66Base excision repair_Homo sapiens_hsa034100.61605813
67Calcium signaling pathway_Homo sapiens_hsa040200.60930741
68Metabolic pathways_Homo sapiens_hsa011000.59957391
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58943758
70Fanconi anemia pathway_Homo sapiens_hsa034600.58551159
71Glutathione metabolism_Homo sapiens_hsa004800.56578658
72N-Glycan biosynthesis_Homo sapiens_hsa005100.55898922
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.55110225
74Gap junction_Homo sapiens_hsa045400.54360607
75Biosynthesis of amino acids_Homo sapiens_hsa012300.52918815
76Phototransduction_Homo sapiens_hsa047440.50853362
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49253495
78Dorso-ventral axis formation_Homo sapiens_hsa043200.48359368
79PPAR signaling pathway_Homo sapiens_hsa033200.47574815
80Serotonergic synapse_Homo sapiens_hsa047260.46654009
81Mineral absorption_Homo sapiens_hsa049780.45626145
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45227153
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45108931
84Melanogenesis_Homo sapiens_hsa049160.44569048
85Nucleotide excision repair_Homo sapiens_hsa034200.42142883
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42138275
87Tryptophan metabolism_Homo sapiens_hsa003800.39986674
88mRNA surveillance pathway_Homo sapiens_hsa030150.39758352
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39428236
90Vitamin B6 metabolism_Homo sapiens_hsa007500.37149491
91One carbon pool by folate_Homo sapiens_hsa006700.37118502
92Prostate cancer_Homo sapiens_hsa052150.35454389
93Sulfur metabolism_Homo sapiens_hsa009200.32997821
94Ovarian steroidogenesis_Homo sapiens_hsa049130.32085839
95Histidine metabolism_Homo sapiens_hsa003400.30773698
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26558173
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26076434
98beta-Alanine metabolism_Homo sapiens_hsa004100.25411845
99Protein export_Homo sapiens_hsa030600.24804325
100ABC transporters_Homo sapiens_hsa020100.23633076

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