PQLC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.48023807
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.48023807
3L-phenylalanine metabolic process (GO:0006558)6.38405980
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.38405980
5aromatic amino acid family catabolic process (GO:0009074)5.82717130
6indole-containing compound catabolic process (GO:0042436)5.36862824
7indolalkylamine catabolic process (GO:0046218)5.36862824
8tryptophan catabolic process (GO:0006569)5.36862824
9kynurenine metabolic process (GO:0070189)5.25290625
10cysteine metabolic process (GO:0006534)5.18160109
11bile acid biosynthetic process (GO:0006699)5.09359602
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07000031
13tryptophan metabolic process (GO:0006568)5.02477779
14glyoxylate metabolic process (GO:0046487)4.96646868
15nitrogen cycle metabolic process (GO:0071941)4.87523377
16serine family amino acid catabolic process (GO:0009071)4.82676502
17regulation of cholesterol esterification (GO:0010872)4.80542877
18sulfur amino acid catabolic process (GO:0000098)4.80057104
19negative regulation of fibrinolysis (GO:0051918)4.75277225
20regulation of protein activation cascade (GO:2000257)4.62153177
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57605519
22high-density lipoprotein particle remodeling (GO:0034375)4.53413374
23urea cycle (GO:0000050)4.51008827
24urea metabolic process (GO:0019627)4.51008827
25protein carboxylation (GO:0018214)4.50085358
26peptidyl-glutamic acid carboxylation (GO:0017187)4.50085358
27regulation of fibrinolysis (GO:0051917)4.49947641
28complement activation, alternative pathway (GO:0006957)4.49644366
29aromatic amino acid family metabolic process (GO:0009072)4.43372527
30amino-acid betaine metabolic process (GO:0006577)4.38554858
31glycine metabolic process (GO:0006544)4.38333640
32alpha-linolenic acid metabolic process (GO:0036109)4.38216325
33regulation of complement activation (GO:0030449)4.36594878
34bile acid metabolic process (GO:0008206)4.31271729
35negative regulation of erythrocyte differentiation (GO:0045647)4.26240794
36coenzyme catabolic process (GO:0009109)4.07397908
37serine family amino acid metabolic process (GO:0009069)3.99106557
38lysine catabolic process (GO:0006554)3.98933701
39lysine metabolic process (GO:0006553)3.98933701
40alpha-amino acid catabolic process (GO:1901606)3.98301971
41regulation of triglyceride catabolic process (GO:0010896)3.91910779
42plasma lipoprotein particle remodeling (GO:0034369)3.91687133
43protein-lipid complex remodeling (GO:0034368)3.91687133
44macromolecular complex remodeling (GO:0034367)3.91687133
45bile acid and bile salt transport (GO:0015721)3.91471411
46amine catabolic process (GO:0009310)3.87750368
47cellular biogenic amine catabolic process (GO:0042402)3.87750368
48phospholipid efflux (GO:0033700)3.87695010
49reverse cholesterol transport (GO:0043691)3.80480793
50triglyceride homeostasis (GO:0070328)3.80431163
51acylglycerol homeostasis (GO:0055090)3.80431163
52tyrosine metabolic process (GO:0006570)3.78514657
53fibrinolysis (GO:0042730)3.76148628
54homocysteine metabolic process (GO:0050667)3.73838315
55cellular glucuronidation (GO:0052695)3.72905082
56benzene-containing compound metabolic process (GO:0042537)3.70050616
57cellular amino acid catabolic process (GO:0009063)3.68810734
58serine family amino acid biosynthetic process (GO:0009070)3.65095962
59cellular ketone body metabolic process (GO:0046950)3.64160103
60indolalkylamine metabolic process (GO:0006586)3.63866451
61positive regulation of lipoprotein lipase activity (GO:0051006)3.61998594
62positive regulation of triglyceride lipase activity (GO:0061365)3.61998594
63response to peptidoglycan (GO:0032494)3.61005879
64cofactor catabolic process (GO:0051187)3.60282864
65blood coagulation, intrinsic pathway (GO:0007597)3.58371138
66imidazole-containing compound metabolic process (GO:0052803)3.58274693
67negative regulation of sterol transport (GO:0032372)3.56447796
68negative regulation of cholesterol transport (GO:0032375)3.56447796
69low-density lipoprotein particle remodeling (GO:0034374)3.52943196
70arginine metabolic process (GO:0006525)3.51888193
71intestinal cholesterol absorption (GO:0030299)3.47749295
72regulation of cholesterol homeostasis (GO:2000188)3.46932178
73plasma lipoprotein particle clearance (GO:0034381)3.45290550
74heme transport (GO:0015886)3.41832557
75complement activation, classical pathway (GO:0006958)3.40016788
76glucuronate metabolic process (GO:0019585)3.38698873
77uronic acid metabolic process (GO:0006063)3.38698873
78carboxylic acid catabolic process (GO:0046395)3.37951103
79organic acid catabolic process (GO:0016054)3.37951103
80aldehyde catabolic process (GO:0046185)3.36992136
81ethanol oxidation (GO:0006069)3.36636177
82urate metabolic process (GO:0046415)3.35139571
83carnitine metabolic process (GO:0009437)3.34818425
84cellular modified amino acid catabolic process (GO:0042219)3.33904158
85protein activation cascade (GO:0072376)3.33112576
86cholesterol efflux (GO:0033344)3.32810983
87NAD biosynthetic process (GO:0009435)3.31728854
88complement activation (GO:0006956)3.31538303
89xenobiotic catabolic process (GO:0042178)3.30107491
902-oxoglutarate metabolic process (GO:0006103)3.27001837
91nicotinamide nucleotide biosynthetic process (GO:0019359)3.23349919
92pyridine nucleotide biosynthetic process (GO:0019363)3.23349919
93regulation of bile acid biosynthetic process (GO:0070857)3.22884012
94acetyl-CoA metabolic process (GO:0006084)3.21450790
95pyrimidine nucleoside catabolic process (GO:0046135)3.19626933
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18862578
97negative regulation of cell killing (GO:0031342)3.18862578
98fatty acid catabolic process (GO:0009062)3.16401223
99monocarboxylic acid catabolic process (GO:0072329)3.16341506
100cholesterol homeostasis (GO:0042632)3.16163430
101fatty acid oxidation (GO:0019395)3.15308270
102glutamate metabolic process (GO:0006536)3.13797424
103detection of other organism (GO:0098543)3.13709452
104regulation of cholesterol metabolic process (GO:0090181)3.13635011
105detection of bacterium (GO:0016045)3.12603789
106response to nitrosative stress (GO:0051409)3.11445001
107macrophage activation involved in immune response (GO:0002281)3.08069558
108modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01382097
109positive regulation by organism of defense response of other organism involved in symbiotic interact3.01382097
110modulation by symbiont of host immune response (GO:0052553)3.01382097
111positive regulation by symbiont of host defense response (GO:0052509)3.01382097
112modulation by symbiont of host defense response (GO:0052031)3.01382097
113modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01382097
114mannose metabolic process (GO:0006013)2.98006073
115negative regulation of interleukin-12 production (GO:0032695)2.95704367
116regulation of T-helper 2 cell differentiation (GO:0045628)2.95197606
117positive regulation of gamma-delta T cell activation (GO:0046645)2.94591130
118low-density lipoprotein particle clearance (GO:0034383)2.91416660
119detection of external biotic stimulus (GO:0098581)2.88570961
120cellular response to thyroid hormone stimulus (GO:0097067)2.85082693
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82301435
122detection of molecule of bacterial origin (GO:0032490)2.80261746
123germinal center formation (GO:0002467)2.80042534
124neutrophil activation involved in immune response (GO:0002283)2.77952967
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77894214
126antigen processing and presentation of endogenous antigen (GO:0019883)2.75165855
127response to muramyl dipeptide (GO:0032495)2.74690943
128regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73293793
129lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73022498
130regulation of leukocyte degranulation (GO:0043300)2.66526238
131immunoglobulin mediated immune response (GO:0016064)2.66094990
132barbed-end actin filament capping (GO:0051016)2.65062253
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.64817452
134negative regulation of granulocyte differentiation (GO:0030853)2.61017156
135acute-phase response (GO:0006953)2.60239544
136protein localization to endosome (GO:0036010)2.59454246
137regulation of mast cell degranulation (GO:0043304)2.59250532
138positive regulation of extracellular matrix organization (GO:1903055)2.58981382
139positive regulation of fatty acid biosynthetic process (GO:0045723)2.57929785
140detection of biotic stimulus (GO:0009595)2.57339659
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.56454095
142regulation of cholesterol storage (GO:0010885)2.51456422
143response to thyroid hormone (GO:0097066)2.50795158
144activation of MAPKKK activity (GO:0000185)2.49848099
145NIK/NF-kappaB signaling (GO:0038061)2.47468030
146positive regulation of cholesterol efflux (GO:0010875)2.46326211
147negative regulation of cytokine production involved in immune response (GO:0002719)2.44874126
148positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43847862
149positive regulation of cellular amide metabolic process (GO:0034250)2.41133928
150regulation of gamma-delta T cell activation (GO:0046643)2.38592104
151negative regulation of leukocyte mediated immunity (GO:0002704)2.36564491
152adhesion of symbiont to host (GO:0044406)2.36063167
153regulation of regulated secretory pathway (GO:1903305)2.34131848
154glycosphingolipid catabolic process (GO:0046479)2.32407245
155regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.29106331
156adhesion of symbiont to host cell (GO:0044650)2.28547304
157virion attachment to host cell (GO:0019062)2.28547304
158hydrogen peroxide biosynthetic process (GO:0050665)2.28305793
159negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.27408434
160modulation by symbiont of host cellular process (GO:0044068)2.26564268
161regulation of mast cell activation involved in immune response (GO:0033006)2.26398300
162negative regulation of toll-like receptor signaling pathway (GO:0034122)2.24403140
163positive thymic T cell selection (GO:0045059)2.23641232
164pinocytosis (GO:0006907)2.23296763
165negative regulation of lymphocyte mediated immunity (GO:0002707)2.23261322
166positive regulation of phagocytosis (GO:0050766)2.22965041
167negative regulation of innate immune response (GO:0045824)2.22678060
168N-acetylneuraminate metabolic process (GO:0006054)2.22307478
169positive regulation of type 2 immune response (GO:0002830)2.18823782
170positive regulation of blood coagulation (GO:0030194)2.18260054
171positive regulation of hemostasis (GO:1900048)2.18260054
172killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.18192696
173disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.18192696
174regulation of early endosome to late endosome transport (GO:2000641)2.18149220
175regulation of monocyte differentiation (GO:0045655)2.17139710
176myeloid dendritic cell differentiation (GO:0043011)2.16943426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.74590367
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.73059861
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.88705337
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.41049179
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.90212840
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.81070891
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71508372
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.49711922
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.68300704
10VDR_21846776_ChIP-Seq_THP-1_Human2.77486863
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62085188
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.49207722
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.48968205
14ZNF263_19887448_ChIP-Seq_K562_Human2.30311362
15GATA1_22025678_ChIP-Seq_K562_Human2.25798299
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16871325
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.11700578
18VDR_24763502_ChIP-Seq_THP-1_Human2.00861505
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00859808
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97457030
21KDM2B_26808549_Chip-Seq_DND41_Human1.95380719
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94103907
23TCF7_22412390_ChIP-Seq_EML_Mouse1.92121607
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82785542
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77688120
26MYC_22102868_ChIP-Seq_BL_Human1.76527524
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75486766
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73765405
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71354219
30P68_20966046_ChIP-Seq_HELA_Human1.69958939
31RACK7_27058665_Chip-Seq_MCF-7_Human1.68902343
32KDM2B_26808549_Chip-Seq_K562_Human1.68100643
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64620455
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64044330
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61735287
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.57760596
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56622043
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55672614
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.54278296
40SMC4_20622854_ChIP-Seq_HELA_Human1.51226788
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.50470814
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50297646
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.49642006
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.48364746
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48155426
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47648455
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46550554
48MAF_26560356_Chip-Seq_TH1_Human1.46114054
49CLOCK_20551151_ChIP-Seq_293T_Human1.46065689
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46052939
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44704591
52* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44019825
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43439776
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.42085296
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41246262
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38391248
57SPI1_23127762_ChIP-Seq_K562_Human1.37772321
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35657651
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34798628
60SCL_19346495_ChIP-Seq_HPC-7_Human1.34596160
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31835633
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31099539
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.29664495
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29489772
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29474325
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28666036
67UTX_26944678_Chip-Seq_JUKART_Human1.27398237
68MAF_26560356_Chip-Seq_TH2_Human1.26748111
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24946159
70HTT_18923047_ChIP-ChIP_STHdh_Human1.23270143
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.22464821
72* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20934392
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20725816
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20175896
75CTCF_27219007_Chip-Seq_Bcells_Human1.19643720
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18621617
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.17883929
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17550270
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.17514390
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15535038
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15529176
82CREB1_26743006_Chip-Seq_LNCaP_Human1.15222446
83RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14900717
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13136826
85KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12916598
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12428406
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11409460
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10529438
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09310845
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09186404
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07625851
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07608910
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05676176
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05616975
95PHF8_20622854_ChIP-Seq_HELA_Human1.04830128
96* DROSHA_22980978_ChIP-Seq_HELA_Human1.04731542
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03810893
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03540586
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.03446799
100E2F1_20622854_ChIP-Seq_HELA_Human1.03436228
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02517624
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02492561
103* TP63_22573176_ChIP-Seq_HFKS_Human1.02485962
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02165794
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01984672
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01419343
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.00520571
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97799896
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.96765830
110GABP_17652178_ChIP-ChIP_JURKAT_Human0.95874424
111GATA4_25053715_ChIP-Seq_YYC3_Human0.94929200
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94213311
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92722560
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.92317358
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90717694
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88783384
117* HNF4A_19822575_ChIP-Seq_HepG2_Human0.88572155
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87922769
119BCOR_27268052_Chip-Seq_Bcells_Human0.86457789
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85647489
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85352327
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84193771
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84146307
124* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83770929
125ETS1_20019798_ChIP-Seq_JURKAT_Human0.83430896
126BCL6_27268052_Chip-Seq_Bcells_Human0.83121095
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82124568
128* RARA_24833708_ChIP-Seq_LIVER_Mouse0.79880478
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79111001
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78445511
131* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77802541
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.76271752
133* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76027445
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75942394
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75851500
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75561821
137* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74965756
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74558988
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.73411374
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72699521
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72692092
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71460741
143RARB_24833708_ChIP-Seq_LIVER_Mouse0.71209304
144* FOXA2_19822575_ChIP-Seq_HepG2_Human0.70883997
145LXR_22292898_ChIP-Seq_THP-1_Human0.70820443
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70574322
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69813133
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69333444
149AR_20517297_ChIP-Seq_VCAP_Human0.68598783
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.68417289
151TAF2_19829295_ChIP-Seq_ESCs_Human0.67959185
152GATA1_19941826_ChIP-Seq_K562_Human0.67306869
153EGR1_19032775_ChIP-ChIP_M12_Human0.66930443
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65097426
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65095267
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.65053284
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65000149
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.62664191
159SA1_27219007_Chip-Seq_Bcells_Human0.62063640
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.62015078
161CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61553291
162CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61330773
163EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.61056733
164ATF3_27146783_Chip-Seq_COLON_Human0.60909773
165ERG_20517297_ChIP-Seq_VCAP_Human0.60853883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.75153805
2MP0005360_urolithiasis5.95472150
3MP0005365_abnormal_bile_salt5.61089234
4MP0005085_abnormal_gallbladder_physiolo5.58977407
5MP0008875_abnormal_xenobiotic_pharmacok4.43299592
6MP0003806_abnormal_nucleotide_metabolis4.10276180
7MP0005083_abnormal_biliary_tract3.85656588
8MP0003303_peritoneal_inflammation3.85469830
9MP0009840_abnormal_foam_cell3.81455317
10MP0010329_abnormal_lipoprotein_level3.08938923
11MP0003172_abnormal_lysosome_physiology2.81391267
12MP0001666_abnormal_nutrient_absorption2.74199108
13MP0003191_abnormal_cellular_cholesterol2.71864860
14MP0005332_abnormal_amino_acid2.62522944
15MP0003656_abnormal_erythrocyte_physiolo2.60615033
16MP0003195_calcinosis2.54747101
17MP0003252_abnormal_bile_duct2.42388798
18MP0004510_myositis2.09933219
19MP0009278_abnormal_bone_marrow2.06408354
20MP0000685_abnormal_immune_system1.95560131
21MP0002118_abnormal_lipid_homeostasis1.93364527
22MP0000609_abnormal_liver_physiology1.91585575
23MP0005000_abnormal_immune_tolerance1.90321077
24MP0003868_abnormal_feces_composition1.89715430
25MP0006082_CNS_inflammation1.88740923
26MP0002148_abnormal_hypersensitivity_rea1.86204848
27MP0003300_gastrointestinal_ulcer1.85865906
28MP0004019_abnormal_vitamin_homeostasis1.84278919
29MP0001835_abnormal_antigen_presentation1.81369841
30MP0001533_abnormal_skeleton_physiology1.81100228
31MP0005319_abnormal_enzyme/_coenzyme1.80696901
32MP0001764_abnormal_homeostasis1.76794715
33MP0005387_immune_system_phenotype1.76346623
34MP0001790_abnormal_immune_system1.76346623
35MP0004147_increased_porphyrin_level1.71723468
36MP0005451_abnormal_body_composition1.64383168
37MP0003186_abnormal_redox_activity1.62826860
38MP0003690_abnormal_glial_cell1.58493541
39MP0003879_abnormal_hair_cell1.55310709
40MP0009697_abnormal_copulation1.52854750
41MP0005167_abnormal_blood-brain_barrier1.50838077
42MP0008260_abnormal_autophagy1.46703290
43MP0002723_abnormal_immune_serum1.45402458
44MP0001800_abnormal_humoral_immune1.41274804
45MP0002998_abnormal_bone_remodeling1.40126698
46MP0002452_abnormal_antigen_presenting1.38934339
47MP0000343_altered_response_to1.38515659
48MP0006036_abnormal_mitochondrial_physio1.37801311
49MP0003724_increased_susceptibility_to1.37598874
50MP0002138_abnormal_hepatobiliary_system1.37089436
51MP0005166_decreased_susceptibility_to1.35191197
52MP0005584_abnormal_enzyme/coenzyme_acti1.32990387
53MP0005671_abnormal_response_to1.32793565
54MP0009643_abnormal_urine_homeostasis1.32642291
55MP0002420_abnormal_adaptive_immunity1.30913826
56MP0001819_abnormal_immune_cell1.29638066
57MP0003453_abnormal_keratinocyte_physiol1.29599249
58MP0009333_abnormal_splenocyte_physiolog1.28633890
59MP0010155_abnormal_intestine_physiology1.25375616
60MP0005636_abnormal_mineral_homeostasis1.23939647
61MP0003828_pulmonary_edema1.21273191
62MP0009764_decreased_sensitivity_to1.20289915
63MP0000858_altered_metastatic_potential1.17207840
64MP0010368_abnormal_lymphatic_system1.16214916
65MP0002405_respiratory_system_inflammati1.15136817
66MP0001849_ear_inflammation1.14741319
67MP0008874_decreased_physiological_sensi1.14150550
68MP0005666_abnormal_adipose_tissue1.14138026
69MP0008469_abnormal_protein_level1.09957875
70MP0005084_abnormal_gallbladder_morpholo1.09360394
71MP0003183_abnormal_peptide_metabolism1.09316813
72MP0000598_abnormal_liver_morphology1.08538792
73MP0005220_abnormal_exocrine_pancreas1.08443296
74MP0002132_abnormal_respiratory_system1.06344362
75MP0003011_delayed_dark_adaptation1.05685037
76MP0000604_amyloidosis1.04846693
77MP0002254_reproductive_system_inflammat1.03876223
78MP0005310_abnormal_salivary_gland1.00658272
79MP0000920_abnormal_myelination1.00384938
80MP0002971_abnormal_brown_adipose1.00136543
81MP0009763_increased_sensitivity_to0.99799490
82MP0005464_abnormal_platelet_physiology0.97846359
83MP0002796_impaired_skin_barrier0.94455952
84MP0003436_decreased_susceptibility_to0.93820126
85MP0000716_abnormal_immune_system0.93327737
86MP0004782_abnormal_surfactant_physiolog0.93054271
87MP0004858_abnormal_nervous_system0.91845937
88MP0003279_aneurysm0.90914583
89MP0009379_abnormal_foot_pigmentation0.89695251
90MP0004381_abnormal_hair_follicle0.88466839
91MP0009642_abnormal_blood_homeostasis0.87815603
92MP0005375_adipose_tissue_phenotype0.86713688
93MP0008004_abnormal_stomach_pH0.86445987
94MP0004859_abnormal_synaptic_plasticity0.85721637
95MP0005376_homeostasis/metabolism_phenot0.85323441
96MP0000249_abnormal_blood_vessel0.84699668
97MP0003091_abnormal_cell_migration0.84213594
98MP0005647_abnormal_sex_gland0.84173580
99MP0002837_dystrophic_cardiac_calcinosis0.84041509
100MP0004185_abnormal_adipocyte_glucose0.83553280
101MP0001756_abnormal_urination0.83074525
102MP0002933_joint_inflammation0.82621216
103MP0003763_abnormal_thymus_physiology0.82577531
104MP0002398_abnormal_bone_marrow0.82005409
105MP0001851_eye_inflammation0.81071361
106MP0005390_skeleton_phenotype0.79135670
107MP0003718_maternal_effect0.79120102
108MP0005076_abnormal_cell_differentiation0.77880307
109MP0003705_abnormal_hypodermis_morpholog0.77421144
110MP0009765_abnormal_xenobiotic_induced0.77046578
111MP0006035_abnormal_mitochondrial_morpho0.76268556
112MP0005023_abnormal_wound_healing0.74486456
113MP0001663_abnormal_digestive_system0.73666259
114MP0002429_abnormal_blood_cell0.72959278
115MP0004130_abnormal_muscle_cell0.70261965
116MP0003329_amyloid_beta_deposits0.69519116
117MP0000689_abnormal_spleen_morphology0.67957817
118MP0005058_abnormal_lysosome_morphology0.67948962
119MP0002722_abnormal_immune_system0.67668396
120MP0001542_abnormal_bone_strength0.66566269
121MP0005535_abnormal_body_temperature0.65874808
122MP0002078_abnormal_glucose_homeostasis0.64643592
123MP0006276_abnormal_autonomic_nervous0.63355705
124MP0001986_abnormal_taste_sensitivity0.62723762
125MP0002735_abnormal_chemical_nociception0.62614401
126MP0005397_hematopoietic_system_phenotyp0.61820007
127MP0001545_abnormal_hematopoietic_system0.61820007
128MP0005408_hypopigmentation0.60196529
129MP0005266_abnormal_metabolism0.59654625
130MP0005334_abnormal_fat_pad0.59621888
131MP0001845_abnormal_inflammatory_respons0.59558472
132MP0003646_muscle_fatigue0.57320711
133MP0001853_heart_inflammation0.56911480
134MP0002419_abnormal_innate_immunity0.56387813
135MP0008873_increased_physiological_sensi0.56278877
136MP0004883_abnormal_blood_vessel0.55419552
137MP0003638_abnormal_response/metabolism_0.54538911
138MP0002060_abnormal_skin_morphology0.54490932
139MP0000465_gastrointestinal_hemorrhage0.53862079
140MP0004947_skin_inflammation0.53304152
141MP0005448_abnormal_energy_balance0.51645188
142MP0002876_abnormal_thyroid_physiology0.51463757
143MP0009931_abnormal_skin_appearance0.51216098
144MP0000579_abnormal_nail_morphology0.51179356
145MP0001661_extended_life_span0.51018123
146MP0005670_abnormal_white_adipose0.50622390
147MP0005165_increased_susceptibility_to0.50574242
148MP0000230_abnormal_systemic_arterial0.49625562
149MP0002136_abnormal_kidney_physiology0.48890983
150MP0005164_abnormal_response_to0.48088825
151MP0001243_abnormal_dermal_layer0.46416023
152MP0005025_abnormal_response_to0.45668224
153MP0002332_abnormal_exercise_endurance0.45583522
154MP0005075_abnormal_melanosome_morpholog0.45353600
155MP0003075_altered_response_to0.44721883
156MP0001216_abnormal_epidermal_layer0.44401266
157MP0009785_altered_susceptibility_to0.43771576
158MP0005595_abnormal_vascular_smooth0.42766524

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37379387
2Intrahepatic cholestasis (HP:0001406)5.52331723
3Deep venous thrombosis (HP:0002625)5.50230343
4Xanthomatosis (HP:0000991)5.20139056
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.12216131
6Prolonged partial thromboplastin time (HP:0003645)5.02712127
7Hypobetalipoproteinemia (HP:0003563)4.66516463
8Hyperlipoproteinemia (HP:0010980)4.56667509
9Complement deficiency (HP:0004431)4.27558387
10Hyperglycinemia (HP:0002154)4.24787935
11Abnormality of glycolipid metabolism (HP:0010969)4.12374174
12Abnormality of liposaccharide metabolism (HP:0010968)4.12374174
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.12374174
14Joint hemorrhage (HP:0005261)3.77250727
15Hyperammonemia (HP:0001987)3.71806918
16Hyperglycinuria (HP:0003108)3.61614376
17Fat malabsorption (HP:0002630)3.58081985
18Abnormality of the common coagulation pathway (HP:0010990)3.57011881
19Eczematoid dermatitis (HP:0000976)3.56567061
20Hypolipoproteinemia (HP:0010981)3.56280636
21Ketosis (HP:0001946)3.50510880
22Increased cerebral lipofuscin (HP:0011813)3.50134356
23Dysostosis multiplex (HP:0000943)3.43082572
24Abnormality of fatty-acid metabolism (HP:0004359)3.42727684
25Conjugated hyperbilirubinemia (HP:0002908)3.40703506
26Abnormality of serine family amino acid metabolism (HP:0010894)3.39606761
27Abnormality of glycine metabolism (HP:0010895)3.39606761
28Abnormality of macrophages (HP:0004311)3.34001542
29Abnormality of the intrinsic pathway (HP:0010989)3.32698869
30Abnormality of complement system (HP:0005339)3.29781935
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.28578506
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.27730902
33Purpura (HP:0000979)3.25158972
34Epidermoid cyst (HP:0200040)3.21845555
35Hypoalphalipoproteinemia (HP:0003233)3.20925194
36Abnormality of methionine metabolism (HP:0010901)3.17665497
37Hyperbilirubinemia (HP:0002904)3.17211452
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16673445
39Gout (HP:0001997)3.15063994
40Hypoglycemic coma (HP:0001325)3.12916242
41Increased neuronal autofluorescent lipopigment (HP:0002074)3.06145928
42Neurofibrillary tangles (HP:0002185)3.04595368
43Steatorrhea (HP:0002570)3.04126641
44Abnormality of aspartate family amino acid metabolism (HP:0010899)3.00471047
45Abnormality of pyrimidine metabolism (HP:0004353)2.98528319
46Myositis (HP:0100614)2.97230118
47Recurrent abscess formation (HP:0002722)2.93948402
48Abnormality of serum amino acid levels (HP:0003112)2.92439952
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.91405781
50Abnormality of polysaccharide metabolism (HP:0011012)2.86168589
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86168589
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86168589
53Orchitis (HP:0100796)2.84955835
54Dicarboxylic aciduria (HP:0003215)2.79755277
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79755277
56Lethargy (HP:0001254)2.77735353
57Loss of speech (HP:0002371)2.72637659
58Abnormality of nucleobase metabolism (HP:0010932)2.71190510
59Recurrent bacterial skin infections (HP:0005406)2.69178141
60Mucopolysacchariduria (HP:0008155)2.69045219
61Urinary glycosaminoglycan excretion (HP:0003541)2.69045219
62Systemic lupus erythematosus (HP:0002725)2.68487778
63Hypercholesterolemia (HP:0003124)2.67565369
64Cerebral edema (HP:0002181)2.65621734
65Generalized aminoaciduria (HP:0002909)2.63855510
66Cerebral inclusion bodies (HP:0100314)2.62708147
67Mediastinal lymphadenopathy (HP:0100721)2.60915528
68Abnormality of purine metabolism (HP:0004352)2.57521606
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.57376911
70Vacuolated lymphocytes (HP:0001922)2.56820236
71Hemorrhage of the eye (HP:0011885)2.55311466
72Metabolic acidosis (HP:0001942)2.54792220
73Axonal loss (HP:0003447)2.52740394
74Increased IgE level (HP:0003212)2.50179937
75Myocardial infarction (HP:0001658)2.44971083
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44377758
77Retrobulbar optic neuritis (HP:0100654)2.42232702
78Optic neuritis (HP:0100653)2.42232702
79Obstructive lung disease (HP:0006536)2.41072466
80Chronic obstructive pulmonary disease (HP:0006510)2.41072466
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39355298
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39355298
83Asymmetric septal hypertrophy (HP:0001670)2.38656610
84Increased muscle lipid content (HP:0009058)2.37818848
85Spontaneous abortion (HP:0005268)2.35291366
86Recurrent gram-negative bacterial infections (HP:0005420)2.34785911
87Increased intramyocellular lipid droplets (HP:0012240)2.32359784
88Cellulitis (HP:0100658)2.31740663
89Elevated erythrocyte sedimentation rate (HP:0003565)2.31238908
90Poikilocytosis (HP:0004447)2.31083895
91Delayed CNS myelination (HP:0002188)2.31055220
92Abnormality of the nasal mucosa (HP:0000433)2.30756494
93Supranuclear gaze palsy (HP:0000605)2.29825235
94Glomerulonephritis (HP:0000099)2.29560154
95Ketoacidosis (HP:0001993)2.28347745
96Gingivitis (HP:0000230)2.28267805
97Hepatic necrosis (HP:0002605)2.27324461
98Abnormality of iron homeostasis (HP:0011031)2.26587501
99Acanthocytosis (HP:0001927)2.25883758
100Brushfield spots (HP:0001088)2.25067258
101Mutism (HP:0002300)2.24882068
102Amyloidosis (HP:0011034)2.24670825
103Polygenic inheritance (HP:0010982)2.23694197
104Abnormal gallbladder morphology (HP:0012437)2.23386073
105Hypertriglyceridemia (HP:0002155)2.23005205
106Cholelithiasis (HP:0001081)2.22062591
107Abnormality of transition element cation homeostasis (HP:0011030)2.21936524
108Neuronal loss in central nervous system (HP:0002529)2.21515390
109Pancreatitis (HP:0001733)2.17953976
110Nausea (HP:0002018)2.17113735
111Increased serum ferritin (HP:0003281)2.16532639
112Stomatitis (HP:0010280)2.16012522
113Prolonged bleeding time (HP:0003010)2.15543327
114Nephritis (HP:0000123)2.14737160
115Gastrointestinal infarctions (HP:0005244)2.14306907
116Abnormality of the Achilles tendon (HP:0005109)2.14217895
117Hepatocellular carcinoma (HP:0001402)2.13980407
118Irritability (HP:0000737)2.12540594
119Polycythemia (HP:0001901)2.12437169
120Neonatal onset (HP:0003623)2.11524673
121Meningitis (HP:0001287)2.09286206
122Vomiting (HP:0002013)2.09127470
123Spontaneous hematomas (HP:0007420)2.08858920
124Achilles tendon contracture (HP:0001771)2.07331999
125Thoracic kyphosis (HP:0002942)2.06914537
126Alopecia of scalp (HP:0002293)2.06690129
127Palpitations (HP:0001962)2.05225749
128Menorrhagia (HP:0000132)2.03577272
129Nuclear cataract (HP:0100018)2.02372720
130Skin nodule (HP:0200036)2.00185723
131Abnormality of urine glucose concentration (HP:0011016)1.99181400
132Glycosuria (HP:0003076)1.99181400
133Reduced antithrombin III activity (HP:0001976)1.98404539
134Pulmonary embolism (HP:0002204)1.98046332
135Opisthotonus (HP:0002179)1.97890133
136Thrombophlebitis (HP:0004418)1.97694305
137Distal lower limb muscle weakness (HP:0009053)1.97399380
138Obstructive sleep apnea (HP:0002870)1.96855389
139Visual hallucinations (HP:0002367)1.96246361
140Nasal polyposis (HP:0100582)1.95974810
141Gingival bleeding (HP:0000225)1.95331601
142Pathologic fracture (HP:0002756)1.95197428
143Petechiae (HP:0000967)1.95167593
144Cholecystitis (HP:0001082)1.94497043
145Abnormal gallbladder physiology (HP:0012438)1.94497043
146Lactic acidosis (HP:0003128)1.94179176
147Vertebral compression fractures (HP:0002953)1.94128987
148Rhabdomyolysis (HP:0003201)1.92322117
149Late onset (HP:0003584)1.88047464
150Colitis (HP:0002583)1.86404751
151Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85477658
152Vasculitis (HP:0002633)1.84991754
153Malnutrition (HP:0004395)1.84247451
154Hepatocellular necrosis (HP:0001404)1.84126805
155Epistaxis (HP:0000421)1.83040989
156Gastrointestinal stroma tumor (HP:0100723)1.83005790
157Recurrent skin infections (HP:0001581)1.82493033
158Pulmonary infiltrates (HP:0002113)1.82097784
159Increased purine levels (HP:0004368)1.80779891
160Hyperuricemia (HP:0002149)1.80779891
161Emphysema (HP:0002097)1.80316198
162Dementia (HP:0000726)1.79354927
163Abnormality of the thoracic spine (HP:0100711)1.78861301
164Vascular calcification (HP:0004934)1.78140404
165Hypochromic anemia (HP:0001931)1.77104724
166Hyperglycemia (HP:0003074)1.76269682
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75532917
168Thin bony cortex (HP:0002753)1.74809630
169Keratoconjunctivitis sicca (HP:0001097)1.74484180
170Cerebral palsy (HP:0100021)1.73779479
171Abnormality of the gallbladder (HP:0005264)1.73241311
172Cerebral aneurysm (HP:0004944)1.72273022
173Segmental peripheral demyelination/remyelination (HP:0003481)1.72267983
174Acute encephalopathy (HP:0006846)1.71102787
175Progressive neurologic deterioration (HP:0002344)1.71031335
176Abnormality of the periventricular white matter (HP:0002518)1.69811987
177Urticaria (HP:0001025)1.69511293
178Hepatosplenomegaly (HP:0001433)1.69483594
179Acne (HP:0001061)1.69358008
180Diminished motivation (HP:0000745)1.67448688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.03346136
2ERN13.82163223
3NME23.78301060
4PRPF4B3.77550492
5MAP2K32.87441838
6FGFR42.69993423
7MAP3K32.39679718
8MAPKAPK32.33253980
9RIPK12.19294275
10STK162.15876784
11FLT31.91908865
12PIM21.91247257
13KDR1.89722305
14ARAF1.83172731
15TAOK31.71061242
16IRAK31.68317334
17TYK21.65175579
18TAOK11.62063843
19MAP2K21.59336243
20PIK3CG1.56388530
21MAP2K41.54216467
22MAP2K61.53670280
23INSRR1.49494368
24BRAF1.47333650
25ICK1.44182163
26PINK11.43352515
27SMG11.39762562
28TIE11.39736892
29MAP3K121.37872501
30IRAK41.34971236
31ABL21.31752839
32FES1.29320099
33TNK21.27671722
34ZAP701.26447764
35ERBB41.25773214
36MATK1.25743450
37BUB11.24169820
38KIT1.24096044
39WEE11.23663384
40CSK1.22486192
41MAP3K111.22230399
42BLK1.21213833
43MARK21.20887190
44MAPK111.20005628
45DDR21.19820523
46PDPK11.18607951
47MST1R1.16868699
48MYLK1.15744341
49NME11.15604030
50STK241.14728030
51SIK11.13084526
52DAPK21.10970818
53CAMKK11.09253424
54TGFBR21.07750984
55SIK21.07123861
56TESK11.05710986
57EPHA31.05177824
58EEF2K1.03588517
59EPHA21.01689995
60TBK11.00894724
61PRKD21.00186218
62CDC42BPA0.99967482
63NEK90.98482301
64JAK30.97315813
65GRK60.96076745
66PDK10.95458381
67MOS0.95083381
68PRKD30.94983241
69MAP2K10.94864029
70MAP4K10.94354568
71RPS6KA20.92612044
72ZAK0.91084757
73RIPK40.90636389
74MAPK40.89758033
75TESK20.87494666
76PKN20.87223963
77PAK60.84994621
78TTN0.82928731
79RPS6KL10.82530470
80RPS6KC10.82530470
81GRK50.82325797
82PDK40.79678142
83PDK30.79678142
84DYRK30.79514922
85IKBKE0.78909008
86EIF2AK10.78219440
87FGR0.75887421
88MAP3K10.73229267
89AKT30.73059150
90HCK0.72454801
91BMX0.72352357
92MAP3K50.71578768
93MAP3K60.71469235
94PDK20.69921582
95JAK10.68802982
96CAMK1D0.68517594
97EIF2AK30.68037812
98MAP3K20.67347052
99RPS6KA60.66199685
100MAPK120.65701473
101ADRBK20.65091003
102HIPK20.64002345
103GRK70.63152286
104RPS6KA40.62342738
105JAK20.62103715
106BRSK20.61898607
107PTK60.58737960
108MAP3K70.57960388
109TYRO30.56947538
110MAP3K130.56721203
111TAOK20.55382737
112TGFBR10.54971554
113LYN0.53513087
114MAPK150.53496107
115MAPK70.53257890
116BMPR1B0.53242827
117DYRK1B0.52921270
118TEC0.52810167
119STK380.52727721
120OBSCN0.52489705
121IRAK20.48805330
122EPHB10.48176402
123AURKA0.46752484
124MAP3K90.46568714
125MAP3K140.45658716
126MARK30.45522363
127TXK0.44989865
128PRKG20.44781112
129SGK30.44152376
130SYK0.44011426
131LCK0.42260091
132RPS6KB20.42257465
133CDK80.41980139
134RET0.41732380
135CAMKK20.40892806
136IKBKB0.40536030
137TRIB30.40412789
138NTRK10.39558135
139KSR20.39237620
140PIK3CA0.39204641
141CAMK2G0.38899372
142DAPK30.37867518
143ERBB20.37861315
144PRKACG0.37466578
145IRAK10.36984540
146LMTK20.36975209
147PRKCH0.36566407
148PRKCD0.34140434
149CSF1R0.33476682
150RAF10.33032905
151PRKCZ0.33028947
152BTK0.32774884

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26383046
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03009269
3Other glycan degradation_Homo sapiens_hsa005113.00443614
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87801952
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65480690
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61725147
7Complement and coagulation cascades_Homo sapiens_hsa046102.60329682
8Arginine biosynthesis_Homo sapiens_hsa002202.41758889
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38555658
10Fatty acid degradation_Homo sapiens_hsa000712.37481713
11Vitamin B6 metabolism_Homo sapiens_hsa007502.37005708
12Tryptophan metabolism_Homo sapiens_hsa003802.26889563
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24400521
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21278612
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.16876084
16Peroxisome_Homo sapiens_hsa041462.13347955
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13233914
18Osteoclast differentiation_Homo sapiens_hsa043802.10805157
19Caffeine metabolism_Homo sapiens_hsa002322.07915639
20Chemical carcinogenesis_Homo sapiens_hsa052042.03212341
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02438707
22Folate biosynthesis_Homo sapiens_hsa007901.97506561
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91153265
24Leishmaniasis_Homo sapiens_hsa051401.90315342
25Butanoate metabolism_Homo sapiens_hsa006501.83776624
26Nitrogen metabolism_Homo sapiens_hsa009101.82974532
27Staphylococcus aureus infection_Homo sapiens_hsa051501.80009429
28Histidine metabolism_Homo sapiens_hsa003401.77860806
29beta-Alanine metabolism_Homo sapiens_hsa004101.77608368
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.75667023
31Propanoate metabolism_Homo sapiens_hsa006401.72754630
32Retinol metabolism_Homo sapiens_hsa008301.67132584
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65595673
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65132489
35Fatty acid metabolism_Homo sapiens_hsa012121.58296788
36PPAR signaling pathway_Homo sapiens_hsa033201.56926879
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.53810776
38B cell receptor signaling pathway_Homo sapiens_hsa046621.50746316
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49493883
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49438268
41Fatty acid elongation_Homo sapiens_hsa000621.49121701
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47874258
43Tuberculosis_Homo sapiens_hsa051521.47859480
44Selenocompound metabolism_Homo sapiens_hsa004501.42753526
45Acute myeloid leukemia_Homo sapiens_hsa052211.41038338
46Sulfur relay system_Homo sapiens_hsa041221.40897762
47Phenylalanine metabolism_Homo sapiens_hsa003601.40808159
48Malaria_Homo sapiens_hsa051441.37442376
49Fat digestion and absorption_Homo sapiens_hsa049751.31947845
50Starch and sucrose metabolism_Homo sapiens_hsa005001.31764812
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30741960
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28424011
53Allograft rejection_Homo sapiens_hsa053301.25127755
54Sulfur metabolism_Homo sapiens_hsa009201.23186075
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.23153162
56Pyruvate metabolism_Homo sapiens_hsa006201.21229783
57Tyrosine metabolism_Homo sapiens_hsa003501.19532932
58VEGF signaling pathway_Homo sapiens_hsa043701.17484442
59ABC transporters_Homo sapiens_hsa020101.15716319
60TNF signaling pathway_Homo sapiens_hsa046681.15101270
61Vitamin digestion and absorption_Homo sapiens_hsa049771.12444282
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12220103
63Carbon metabolism_Homo sapiens_hsa012001.11808477
64Bile secretion_Homo sapiens_hsa049761.11106975
65Biosynthesis of amino acids_Homo sapiens_hsa012301.09253992
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07291003
67Toxoplasmosis_Homo sapiens_hsa051451.06172006
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04729182
69Graft-versus-host disease_Homo sapiens_hsa053321.03660072
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02996422
71Steroid biosynthesis_Homo sapiens_hsa001001.02666823
72Glutathione metabolism_Homo sapiens_hsa004801.02427170
73NF-kappa B signaling pathway_Homo sapiens_hsa040641.00117447
74Autoimmune thyroid disease_Homo sapiens_hsa053200.98649650
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.97337333
76Arginine and proline metabolism_Homo sapiens_hsa003300.96628382
77Regulation of autophagy_Homo sapiens_hsa041400.95072450
78Pentose phosphate pathway_Homo sapiens_hsa000300.94897208
79Rheumatoid arthritis_Homo sapiens_hsa053230.94010651
80Phagosome_Homo sapiens_hsa041450.92890691
81Asthma_Homo sapiens_hsa053100.91385587
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87584073
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86811923
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86232515
85African trypanosomiasis_Homo sapiens_hsa051430.85038378
86Influenza A_Homo sapiens_hsa051640.83397732
87Synaptic vesicle cycle_Homo sapiens_hsa047210.82951331
88Amoebiasis_Homo sapiens_hsa051460.82027226
89Salmonella infection_Homo sapiens_hsa051320.82010342
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80033342
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77662905
92Hepatitis C_Homo sapiens_hsa051600.77585408
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.77468552
94Chemokine signaling pathway_Homo sapiens_hsa040620.75911610
95Glycerolipid metabolism_Homo sapiens_hsa005610.75643691
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.75537048
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75413601
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73316986
99Hematopoietic cell lineage_Homo sapiens_hsa046400.72499785
100Notch signaling pathway_Homo sapiens_hsa043300.72128407
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.69329912
102Bladder cancer_Homo sapiens_hsa052190.68939268
103Galactose metabolism_Homo sapiens_hsa000520.68798475
104GnRH signaling pathway_Homo sapiens_hsa049120.68476887
105Chronic myeloid leukemia_Homo sapiens_hsa052200.68377837
106Metabolic pathways_Homo sapiens_hsa011000.68335140
107Type I diabetes mellitus_Homo sapiens_hsa049400.67934885
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67132057
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64208899
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63862270
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62709955
112Endocytosis_Homo sapiens_hsa041440.62261828
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61318191
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61174392
115Non-small cell lung cancer_Homo sapiens_hsa052230.59649596
116Antigen processing and presentation_Homo sapiens_hsa046120.59518408
117T cell receptor signaling pathway_Homo sapiens_hsa046600.59126753
118Fructose and mannose metabolism_Homo sapiens_hsa000510.58889618
119Prolactin signaling pathway_Homo sapiens_hsa049170.58590771
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57987269
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57375268
122Type II diabetes mellitus_Homo sapiens_hsa049300.56860676
123Platelet activation_Homo sapiens_hsa046110.56728110
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.56262258
125Viral myocarditis_Homo sapiens_hsa054160.55458906
126Collecting duct acid secretion_Homo sapiens_hsa049660.53203728
127Legionellosis_Homo sapiens_hsa051340.53042166
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.52244602
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.51491181
130Oxidative phosphorylation_Homo sapiens_hsa001900.51363420
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51313240
132Apoptosis_Homo sapiens_hsa042100.50142447
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.49999124
134Proteasome_Homo sapiens_hsa030500.49877120
135Long-term potentiation_Homo sapiens_hsa047200.45743780
136Renal cell carcinoma_Homo sapiens_hsa052110.45527018
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45432159
138mTOR signaling pathway_Homo sapiens_hsa041500.44431680
139Pancreatic cancer_Homo sapiens_hsa052120.43307057
140Linoleic acid metabolism_Homo sapiens_hsa005910.40601037
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38619596
142Prion diseases_Homo sapiens_hsa050200.37086103
143One carbon pool by folate_Homo sapiens_hsa006700.35932771
144Pyrimidine metabolism_Homo sapiens_hsa002400.34767183
145Parkinsons disease_Homo sapiens_hsa050120.34423656
146RNA polymerase_Homo sapiens_hsa030200.21884730
147Arachidonic acid metabolism_Homo sapiens_hsa005900.21341541
148Lysine degradation_Homo sapiens_hsa003100.20952019
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18937679
150Ribosome_Homo sapiens_hsa030100.18169733
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.14842927
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12563338
153Lysosome_Homo sapiens_hsa041420.11712623
154Alzheimers disease_Homo sapiens_hsa050100.09753256
155Insulin resistance_Homo sapiens_hsa049310.09698809
156Protein export_Homo sapiens_hsa030600.09226887
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.04066876
158Huntingtons disease_Homo sapiens_hsa050160.04013125
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.00480352
160Insulin signaling pathway_Homo sapiens_hsa04910-0.0913721
161Pertussis_Homo sapiens_hsa05133-0.0864510
162Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0596882
163Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0573567
164Purine metabolism_Homo sapiens_hsa00230-0.0490449
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0373952
166Thyroid cancer_Homo sapiens_hsa05216-0.0110536

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