PQBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.13984745
2ATP synthesis coupled proton transport (GO:0015986)4.96664891
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.96664891
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.76220526
5proteasome assembly (GO:0043248)4.76065290
6chaperone-mediated protein transport (GO:0072321)4.64865939
7ribosomal small subunit biogenesis (GO:0042274)4.44166421
8viral transcription (GO:0019083)4.41601847
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37219078
10protein maturation by protein folding (GO:0022417)4.32577684
11rRNA modification (GO:0000154)4.29714257
12translational termination (GO:0006415)4.23288363
13cullin deneddylation (GO:0010388)4.18005328
14protein complex biogenesis (GO:0070271)4.16789670
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12514614
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.12514614
17NADH dehydrogenase complex assembly (GO:0010257)4.12514614
18cotranslational protein targeting to membrane (GO:0006613)3.99681136
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95433264
20protein neddylation (GO:0045116)3.94052073
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.91927592
22termination of RNA polymerase III transcription (GO:0006386)3.91927592
23maturation of 5.8S rRNA (GO:0000460)3.90662723
24protein targeting to ER (GO:0045047)3.89899125
25DNA deamination (GO:0045006)3.89628964
26negative regulation of microtubule polymerization (GO:0031115)3.83809979
27mitochondrial respiratory chain complex assembly (GO:0033108)3.83298936
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81265005
29protein deneddylation (GO:0000338)3.78773093
30protein localization to endoplasmic reticulum (GO:0070972)3.75208326
31establishment of integrated proviral latency (GO:0075713)3.75021173
32ribosomal small subunit assembly (GO:0000028)3.74506151
33GTP biosynthetic process (GO:0006183)3.73771454
34respiratory electron transport chain (GO:0022904)3.71545697
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68591207
36guanosine-containing compound biosynthetic process (GO:1901070)3.66515532
37oxidative phosphorylation (GO:0006119)3.65322426
38electron transport chain (GO:0022900)3.65122158
39translational elongation (GO:0006414)3.63561803
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60738859
41cellular protein complex disassembly (GO:0043624)3.60730740
42pseudouridine synthesis (GO:0001522)3.58912655
43negative regulation of ligase activity (GO:0051352)3.55857638
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55857638
45ribosome assembly (GO:0042255)3.55432039
46protein targeting to mitochondrion (GO:0006626)3.54103769
47viral life cycle (GO:0019058)3.53770460
48positive regulation of ligase activity (GO:0051351)3.53276600
49maturation of SSU-rRNA (GO:0030490)3.48922965
50establishment of protein localization to mitochondrion (GO:0072655)3.48375962
51rRNA methylation (GO:0031167)3.47105555
52DNA damage response, detection of DNA damage (GO:0042769)3.44924628
53ribosome biogenesis (GO:0042254)3.41711119
547-methylguanosine mRNA capping (GO:0006370)3.40561863
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.40049262
56translational initiation (GO:0006413)3.39295069
577-methylguanosine RNA capping (GO:0009452)3.38721764
58RNA capping (GO:0036260)3.38721764
59UTP biosynthetic process (GO:0006228)3.35988931
60regulation of ubiquitin-protein transferase activity (GO:0051438)3.34309296
61dopamine transport (GO:0015872)3.31379595
62translation (GO:0006412)3.30283638
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30178361
64establishment of viral latency (GO:0019043)3.27512617
65regulation of cellular amino acid metabolic process (GO:0006521)3.25533664
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25163879
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24128612
68regulation of ligase activity (GO:0051340)3.22622092
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21600199
70GDP-mannose metabolic process (GO:0019673)3.19062829
71negative regulation of protein ubiquitination (GO:0031397)3.18779198
72regulation of mitochondrial translation (GO:0070129)3.16627398
73protein localization to mitochondrion (GO:0070585)3.16509240
74GMP metabolic process (GO:0046037)3.15001565
75spliceosomal snRNP assembly (GO:0000387)3.13937869
76protein complex disassembly (GO:0043241)3.13259606
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13078262
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13078262
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12515453
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12515453
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11182194
82DNA strand elongation involved in DNA replication (GO:0006271)3.10503567
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09667010
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09667010
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09667010
86cellular component biogenesis (GO:0044085)3.09194797
87inner mitochondrial membrane organization (GO:0007007)3.07959256
88viral mRNA export from host cell nucleus (GO:0046784)3.07619435
89negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.05390165
90spliceosomal complex assembly (GO:0000245)3.05187119
91signal transduction involved in DNA damage checkpoint (GO:0072422)3.04981678
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04981678
93nucleobase-containing small molecule interconversion (GO:0015949)3.04550240
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04303737
95peptidyl-arginine omega-N-methylation (GO:0035247)3.03275032
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.02377185
97macromolecular complex disassembly (GO:0032984)3.01536059
98DNA strand elongation (GO:0022616)3.01491801
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01267662
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00681891
101L-serine metabolic process (GO:0006563)3.00453686
102transcription from mitochondrial promoter (GO:0006390)3.00261004
103viral protein processing (GO:0019082)2.98667363
104ribosomal large subunit biogenesis (GO:0042273)2.97730190
105ribonucleoprotein complex biogenesis (GO:0022613)2.97645266
106mitochondrial transport (GO:0006839)2.96276111
107proline biosynthetic process (GO:0006561)2.95556739
108tRNA aminoacylation for protein translation (GO:0006418)2.95001461
109respiratory chain complex IV assembly (GO:0008535)2.94827124
110telomere maintenance via semi-conservative replication (GO:0032201)2.93797091
111rRNA processing (GO:0006364)2.90510064
112positive regulation of cell cycle arrest (GO:0071158)2.90498004
113protein targeting to membrane (GO:0006612)2.85948928
114amino acid activation (GO:0043038)2.85908961
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85792040
116mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.85702904
117formation of translation preinitiation complex (GO:0001731)2.83553768
118catecholamine transport (GO:0051937)2.82610735
119rRNA metabolic process (GO:0016072)2.82357327
120CTP metabolic process (GO:0046036)2.80797083
121CTP biosynthetic process (GO:0006241)2.80797083
122neuron cell-cell adhesion (GO:0007158)2.80395966
123peptidyl-histidine modification (GO:0018202)2.79909410
124regulation of cellular amine metabolic process (GO:0033238)2.76292078
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.71254180
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.69863145
127histone arginine methylation (GO:0034969)2.68774980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.59875596
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.40682584
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01291433
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.90303260
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80084314
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.71997172
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.68049080
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.49250692
9E2F7_22180533_ChIP-Seq_HELA_Human3.36834660
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.32859555
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30773878
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15191934
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14086781
14* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80144179
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.79194853
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59095125
17EZH2_22144423_ChIP-Seq_EOC_Human2.58862264
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51029184
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50188850
20VDR_23849224_ChIP-Seq_CD4+_Human2.40589032
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33695672
22XRN2_22483619_ChIP-Seq_HELA_Human2.29908522
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24924130
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21605380
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12211384
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.10572429
27TTF2_22483619_ChIP-Seq_HELA_Human2.04251549
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.04221137
29DCP1A_22483619_ChIP-Seq_HELA_Human1.95357604
30GABP_19822575_ChIP-Seq_HepG2_Human1.94551714
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.94426355
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85362099
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.81112123
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75530598
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71007992
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67669202
37ELK1_19687146_ChIP-ChIP_HELA_Human1.64462610
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56365774
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54217716
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52984786
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52540608
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52342910
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48349821
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46987801
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46983984
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42788080
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40813890
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40369006
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.39861046
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38643057
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37747491
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37395215
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36978549
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34040632
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31728090
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31122839
57REST_21632747_ChIP-Seq_MESCs_Mouse1.29706110
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29628425
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28615250
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27617318
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25867682
62TFEB_21752829_ChIP-Seq_HELA_Human1.25615356
63CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25189930
64* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23692028
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.22346055
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22331626
67IRF1_19129219_ChIP-ChIP_H3396_Human1.20367327
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18146432
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15620274
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15497035
71MYC_22102868_ChIP-Seq_BL_Human1.15104165
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15001950
73* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13617572
74MYC_18940864_ChIP-ChIP_HL60_Human1.13594668
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13550644
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12306146
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11832012
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11494381
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.11376894
80CIITA_25753668_ChIP-Seq_RAJI_Human1.10817765
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10097360
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.09442089
83TAF15_26573619_Chip-Seq_HEK293_Human1.09235142
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.08667257
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08213249
86* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06861924
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05829546
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05297828
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04376090
90VDR_21846776_ChIP-Seq_THP-1_Human1.03983210
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03205264
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.03082457
93* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02863152
94IGF1R_20145208_ChIP-Seq_DFB_Human1.02627349
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.01983850
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01261248
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95989216
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.95313508
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95150696
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94332262
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94052496
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93944326
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92281374
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91935644
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91863288
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91744458
107JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91168019
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.91101137
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90761137
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90482783
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90188009
112GBX2_23144817_ChIP-Seq_PC3_Human0.89775267
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89701396
114CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89481563
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88827139
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88234611
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87907797
118ZNF263_19887448_ChIP-Seq_K562_Human0.86730013
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86045945
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85504104
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84354362
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82860034
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82347733
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82031049
125* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81807608
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81583427
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.81405680
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81025912
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.80367283
130EWS_26573619_Chip-Seq_HEK293_Human0.79899600
131* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79261693
132KDM5A_27292631_Chip-Seq_BREAST_Human0.79022558
133E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78827019
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78387277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.53526439
2MP0003880_abnormal_central_pattern4.16653891
3MP0001529_abnormal_vocalization3.22591386
4MP0003186_abnormal_redox_activity3.19894547
5MP0001905_abnormal_dopamine_level2.71234853
6MP0005423_abnormal_somatic_nervous2.64979014
7MP0004859_abnormal_synaptic_plasticity2.55381778
8MP0003122_maternal_imprinting2.49589899
9MP0006276_abnormal_autonomic_nervous2.48781603
10MP0001986_abnormal_taste_sensitivity2.44269742
11MP0002736_abnormal_nociception_after2.43161924
12MP0001968_abnormal_touch/_nociception2.39799316
13MP0009379_abnormal_foot_pigmentation2.37118529
14MP0009745_abnormal_behavioral_response2.36362617
15MP0003635_abnormal_synaptic_transmissio2.36172418
16MP0002163_abnormal_gland_morphology2.30831248
17MP0002064_seizures2.25119979
18MP0008007_abnormal_cellular_replicative2.21399908
19MP0002572_abnormal_emotion/affect_behav2.21287938
20MP0006292_abnormal_olfactory_placode2.13363425
21MP0005645_abnormal_hypothalamus_physiol2.11038813
22MP0005451_abnormal_body_composition2.08850814
23MP0002734_abnormal_mechanical_nocicepti2.08345526
24MP0005058_abnormal_lysosome_morphology2.07455699
25MP0002272_abnormal_nervous_system2.04118561
26MP0004142_abnormal_muscle_tone1.98559066
27MP0009046_muscle_twitch1.97111653
28MP0002063_abnormal_learning/memory/cond1.96179623
29MP0001440_abnormal_grooming_behavior1.94397738
30MP0004147_increased_porphyrin_level1.90386535
31MP0002735_abnormal_chemical_nociception1.89881827
32MP0002184_abnormal_innervation1.88639382
33MP0004270_analgesia1.86352868
34MP0000358_abnormal_cell_content/1.83971156
35MP0001970_abnormal_pain_threshold1.81512899
36MP0009840_abnormal_foam_cell1.76230254
37MP0002733_abnormal_thermal_nociception1.74811311
38MP0002638_abnormal_pupillary_reflex1.72399927
39MP0001486_abnormal_startle_reflex1.67340645
40MP0000372_irregular_coat_pigmentation1.65548975
41MP0001730_embryonic_growth_arrest1.62072120
42MP0005379_endocrine/exocrine_gland_phen1.60165610
43MP0001188_hyperpigmentation1.58739238
44MP0002822_catalepsy1.58438224
45MP0000313_abnormal_cell_death1.56218595
46MP0001501_abnormal_sleep_pattern1.54632852
47MP0006072_abnormal_retinal_apoptosis1.51833922
48MP0000778_abnormal_nervous_system1.50219902
49MP0000350_abnormal_cell_proliferation1.50017636
50MP0002067_abnormal_sensory_capabilities1.46698592
51MP0005075_abnormal_melanosome_morpholog1.45718903
52MP0001764_abnormal_homeostasis1.43167634
53MP0008057_abnormal_DNA_replication1.41703155
54MP0002751_abnormal_autonomic_nervous1.39386382
55MP0001984_abnormal_olfaction1.37854316
56MP0001727_abnormal_embryo_implantation1.36262825
57MP0003315_abnormal_perineum_morphology1.35342703
58MP0003121_genomic_imprinting1.33853324
59MP0002557_abnormal_social/conspecific_i1.33470542
60MP0004742_abnormal_vestibular_system1.32469153
61MP0003693_abnormal_embryo_hatching1.29749868
62MP0004924_abnormal_behavior1.27479683
63MP0005386_behavior/neurological_phenoty1.27479683
64MP0003011_delayed_dark_adaptation1.25835489
65MP0002837_dystrophic_cardiac_calcinosis1.25722364
66MP0010030_abnormal_orbit_morphology1.24809403
67MP0000631_abnormal_neuroendocrine_gland1.23194917
68MP0002132_abnormal_respiratory_system1.22582554
69MP0008789_abnormal_olfactory_epithelium1.21102358
70MP0001853_heart_inflammation1.18785017
71MP0002080_prenatal_lethality1.18270157
72MP0004811_abnormal_neuron_physiology1.10761970
73MP0005499_abnormal_olfactory_system1.10346766
74MP0005394_taste/olfaction_phenotype1.10346766
75MP0002210_abnormal_sex_determination1.09717835
76MP0004957_abnormal_blastocyst_morpholog1.09583397
77MP0003656_abnormal_erythrocyte_physiolo1.08911163
78MP0006035_abnormal_mitochondrial_morpho1.08881455
79MP0003879_abnormal_hair_cell1.08413098
80MP0002102_abnormal_ear_morphology1.07935796
81MP0005330_cardiomyopathy1.07320609
82MP0003763_abnormal_thymus_physiology1.07238100
83MP0008058_abnormal_DNA_repair1.06342069
84MP0005501_abnormal_skin_physiology1.06261858
85MP0002019_abnormal_tumor_incidence1.05816660
86MP0002066_abnormal_motor_capabilities/c1.04179655
87MP0009278_abnormal_bone_marrow1.03525176
88MP0008872_abnormal_physiological_respon1.03242863
89MP0008260_abnormal_autophagy1.01904826
90MP0003221_abnormal_cardiomyocyte_apopto1.01433736
91MP0002882_abnormal_neuron_morphology1.01334392
92MP0005551_abnormal_eye_electrophysiolog1.00901382
93MP0001697_abnormal_embryo_size1.00713641
94MP0010094_abnormal_chromosome_stability1.00491506
95MP0002752_abnormal_somatic_nervous0.98819538
96MP0008877_abnormal_DNA_methylation0.98474252
97MP0003786_premature_aging0.98048079
98MP0002139_abnormal_hepatobiliary_system0.97731882
99MP0005671_abnormal_response_to0.97023883
100MP0002938_white_spotting0.97003104
101MP0005332_abnormal_amino_acid0.96996315
102MP0000955_abnormal_spinal_cord0.95034526
103MP0000490_abnormal_crypts_of0.94783111
104MP0005646_abnormal_pituitary_gland0.94392695
105MP0001502_abnormal_circadian_rhythm0.93703247
106MP0005084_abnormal_gallbladder_morpholo0.93542956
107MP0000678_abnormal_parathyroid_gland0.93362631
108MP0006036_abnormal_mitochondrial_physio0.92876905
109MP0008932_abnormal_embryonic_tissue0.92766398
110MP0008569_lethality_at_weaning0.91167767
111MP0005409_darkened_coat_color0.91098744
112MP0005636_abnormal_mineral_homeostasis0.88310762
113MP0001929_abnormal_gametogenesis0.87628567
114MP0000750_abnormal_muscle_regeneration0.87574580
115MP0003077_abnormal_cell_cycle0.86839952
116MP0003191_abnormal_cellular_cholesterol0.86641281
117MP0003938_abnormal_ear_development0.84577414
118MP0001145_abnormal_male_reproductive0.84297849
119MP0003787_abnormal_imprinting0.83956478
120MP0001963_abnormal_hearing_physiology0.83387971
121MP0005253_abnormal_eye_physiology0.83068103
122MP0005083_abnormal_biliary_tract0.81715352
123MP0003123_paternal_imprinting0.80606697
124MP0003567_abnormal_fetal_cardiomyocyte0.80248311
125MP0001672_abnormal_embryogenesis/_devel0.80071926
126MP0005380_embryogenesis_phenotype0.80071926
127MP0002152_abnormal_brain_morphology0.78553059
128MP0005171_absent_coat_pigmentation0.78529627
129MP0001664_abnormal_digestion0.78262462
130MP0000026_abnormal_inner_ear0.78222791
131MP0002876_abnormal_thyroid_physiology0.76846883
132MP0005408_hypopigmentation0.76597590
133MP0002095_abnormal_skin_pigmentation0.75504298
134MP0003718_maternal_effect0.74079718
135MP0001243_abnormal_dermal_layer0.73233661
136MP0000653_abnormal_sex_gland0.73013549
137MP0008873_increased_physiological_sensi0.72154515
138MP0000703_abnormal_thymus_morphology0.72001375
139MP0009672_abnormal_birth_weight0.70910060
140MP0002090_abnormal_vision0.70091952
141MP0002229_neurodegeneration0.70046111
142MP0005266_abnormal_metabolism0.69954008
143MP0001545_abnormal_hematopoietic_system0.69761367
144MP0005397_hematopoietic_system_phenotyp0.69761367
145MP0002277_abnormal_respiratory_mucosa0.69605459
146MP0010386_abnormal_urinary_bladder0.68893807
147MP0009333_abnormal_splenocyte_physiolog0.68575693
148MP0002396_abnormal_hematopoietic_system0.67386519
149MP0002069_abnormal_eating/drinking_beha0.67065507
150MP0005584_abnormal_enzyme/coenzyme_acti0.66883629
151MP0004233_abnormal_muscle_weight0.66800293
152MP0003111_abnormal_nucleus_morphology0.66614098
153MP0001919_abnormal_reproductive_system0.66236557
154MP0000015_abnormal_ear_pigmentation0.66220720
155MP0005384_cellular_phenotype0.66003168
156MP0002877_abnormal_melanocyte_morpholog0.65584316
157MP0002398_abnormal_bone_marrow0.63758300
158MP0008995_early_reproductive_senescence0.63639357
159MP0003984_embryonic_growth_retardation0.63238052
160MP0002796_impaired_skin_barrier0.62988942
161MP0003136_yellow_coat_color0.62057099
162MP0002148_abnormal_hypersensitivity_rea0.58559128
163MP0002088_abnormal_embryonic_growth/wei0.58216529
164MP0002161_abnormal_fertility/fecundity0.57831274
165MP0001881_abnormal_mammary_gland0.57662557
166MP0005319_abnormal_enzyme/_coenzyme0.57399950
167MP0002429_abnormal_blood_cell0.57164805
168MP0000343_altered_response_to0.57130676
169MP0003698_abnormal_male_reproductive0.57067652
170MP0002085_abnormal_embryonic_tissue0.56753965

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.09647766
2Mitochondrial inheritance (HP:0001427)4.90821688
3Abnormal mitochondria in muscle tissue (HP:0008316)4.66788403
4Increased hepatocellular lipid droplets (HP:0006565)4.30902137
5Hepatocellular necrosis (HP:0001404)4.26250750
6Progressive macrocephaly (HP:0004481)4.08064491
7Increased CSF lactate (HP:0002490)4.05596000
8Abnormality of cells of the erythroid lineage (HP:0012130)3.94494452
9Renal Fanconi syndrome (HP:0001994)3.81505049
10Focal motor seizures (HP:0011153)3.79244636
11Cerebral hypomyelination (HP:0006808)3.78343130
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.77570711
13Acute encephalopathy (HP:0006846)3.72835014
14Abnormal number of erythroid precursors (HP:0012131)3.67352281
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.50982212
16Lipid accumulation in hepatocytes (HP:0006561)3.48349169
17Cholecystitis (HP:0001082)3.32730840
18Abnormal gallbladder physiology (HP:0012438)3.32730840
19Microvesicular hepatic steatosis (HP:0001414)3.24395758
20Oral leukoplakia (HP:0002745)3.21688514
21Exertional dyspnea (HP:0002875)3.17169532
223-Methylglutaconic aciduria (HP:0003535)3.16201971
23Increased intramyocellular lipid droplets (HP:0012240)3.14566900
24Increased serum pyruvate (HP:0003542)3.13386663
25Abnormality of glycolysis (HP:0004366)3.13386663
26Hepatic necrosis (HP:0002605)3.07644939
27Myokymia (HP:0002411)2.93563278
28Limb dystonia (HP:0002451)2.91300274
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89505528
30Increased serum lactate (HP:0002151)2.87735651
31Exercise intolerance (HP:0003546)2.79088377
32Respiratory difficulties (HP:0002880)2.71587519
33Atonic seizures (HP:0010819)2.68122151
34Delusions (HP:0000746)2.66511053
35Optic disc pallor (HP:0000543)2.65968504
36Abnormal hair whorl (HP:0010721)2.65299418
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63777357
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63777357
39Multiple enchondromatosis (HP:0005701)2.62513060
40Leukodystrophy (HP:0002415)2.62111436
41Degeneration of anterior horn cells (HP:0002398)2.61741783
42Abnormality of the anterior horn cell (HP:0006802)2.61741783
43Abnormal trabecular bone morphology (HP:0100671)2.60135801
44Emotional lability (HP:0000712)2.59057218
45Hypothermia (HP:0002045)2.57007129
46Gait imbalance (HP:0002141)2.56664816
47Pancytopenia (HP:0001876)2.54502548
48Abnormal pupillary function (HP:0007686)2.54246700
49Lethargy (HP:0001254)2.50068352
50Abnormality of lateral ventricle (HP:0030047)2.49171342
51Macrocytic anemia (HP:0001972)2.49098543
52Reticulocytopenia (HP:0001896)2.48840055
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45986216
54Lactic acidosis (HP:0003128)2.43503063
55Respiratory failure (HP:0002878)2.41128480
56Abnormality of the labia minora (HP:0012880)2.39790150
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39563051
58Visual hallucinations (HP:0002367)2.38492968
59Medial flaring of the eyebrow (HP:0010747)2.37341626
60Abnormal autonomic nervous system physiology (HP:0012332)2.35410263
61Pallor (HP:0000980)2.34933549
62Esotropia (HP:0000565)2.32204006
63Congenital primary aphakia (HP:0007707)2.31958383
64CNS hypomyelination (HP:0003429)2.30895830
65Severe visual impairment (HP:0001141)2.30828919
66Progressive muscle weakness (HP:0003323)2.29369219
67Abnormality of renal resorption (HP:0011038)2.29072926
68Spastic paraparesis (HP:0002313)2.29068490
69Nephrogenic diabetes insipidus (HP:0009806)2.28241213
70Increased muscle lipid content (HP:0009058)2.25566174
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23793697
72Abnormal protein N-linked glycosylation (HP:0012347)2.23793697
73Abnormal protein glycosylation (HP:0012346)2.23793697
74Abnormal glycosylation (HP:0012345)2.23793697
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22331270
76Ragged-red muscle fibers (HP:0003200)2.17170505
77Sparse eyelashes (HP:0000653)2.15867313
78Generalized aminoaciduria (HP:0002909)2.14829566
79Epileptic encephalopathy (HP:0200134)2.14218706
80Secondary amenorrhea (HP:0000869)2.13684701
81Reduced antithrombin III activity (HP:0001976)2.13292587
82Polyphagia (HP:0002591)2.11773282
83Testicular atrophy (HP:0000029)2.11360412
84Hypoglycemic coma (HP:0001325)2.10385002
85Muscle fiber atrophy (HP:0100295)2.06043190
86Focal seizures (HP:0007359)2.05052946
87Dicarboxylic aciduria (HP:0003215)2.04295648
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04295648
89* Poor suck (HP:0002033)2.04235957
90Absence seizures (HP:0002121)2.03809093
91Gliosis (HP:0002171)2.03712139
92Death in infancy (HP:0001522)2.01241551
93Abnormality of reticulocytes (HP:0004312)2.00469008
94Abnormal rod and cone electroretinograms (HP:0008323)1.98153136
95Type 2 muscle fiber atrophy (HP:0003554)1.96537500
96Hyperventilation (HP:0002883)1.96310783
97Microretrognathia (HP:0000308)1.96059291
98Upper limb muscle weakness (HP:0003484)1.94967966
99Nausea (HP:0002018)1.92837831
100Progressive microcephaly (HP:0000253)1.90645896
101Methylmalonic aciduria (HP:0012120)1.90427030
102Congenital stationary night blindness (HP:0007642)1.89332532
103Heterochromia iridis (HP:0001100)1.89140467
104IgM deficiency (HP:0002850)1.88975959
105Broad distal phalanx of finger (HP:0009836)1.88945799
106Aplastic anemia (HP:0001915)1.88889537
107Cerebral edema (HP:0002181)1.87339279
108Amyotrophic lateral sclerosis (HP:0007354)1.87339061
109Absent thumb (HP:0009777)1.86967854
110CNS demyelination (HP:0007305)1.86743898
111Type I transferrin isoform profile (HP:0003642)1.86393660
112Neuroendocrine neoplasm (HP:0100634)1.86083324
113IgG deficiency (HP:0004315)1.85973669
114Dialeptic seizures (HP:0011146)1.85822859
115Opisthotonus (HP:0002179)1.82855746
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82708779
117Horseshoe kidney (HP:0000085)1.82028811
118Broad-based gait (HP:0002136)1.80497869
119Premature ovarian failure (HP:0008209)1.80065313
120Lissencephaly (HP:0001339)1.78804887
121Febrile seizures (HP:0002373)1.78781611
122Increased IgM level (HP:0003496)1.77030589
123Dysautonomia (HP:0002459)1.75541197
124X-linked dominant inheritance (HP:0001423)1.74830905
125Vomiting (HP:0002013)1.73593501
126Orthostatic hypotension (HP:0001278)1.72976886
127Hypokinesia (HP:0002375)1.72871329
128Agammaglobulinemia (HP:0004432)1.72748992
129Cholelithiasis (HP:0001081)1.72437797
130Trismus (HP:0000211)1.72381897
131* Blindness (HP:0000618)1.71889529
132Glycosuria (HP:0003076)1.71820776
133Abnormality of urine glucose concentration (HP:0011016)1.71820776
134Seborrheic dermatitis (HP:0001051)1.71070701
135Abnormality of methionine metabolism (HP:0010901)1.69753708
136Parakeratosis (HP:0001036)1.68522600
137Unsteady gait (HP:0002317)1.67434548
138Vaginal atresia (HP:0000148)1.66392238
139Vacuolated lymphocytes (HP:0001922)1.65431255
140Birth length less than 3rd percentile (HP:0003561)1.64545875
141Carpal bone hypoplasia (HP:0001498)1.64087051
142Premature graying of hair (HP:0002216)1.63398278
143Cellular immunodeficiency (HP:0005374)1.62633946
144Pheochromocytoma (HP:0002666)1.61903124
145Aplasia/hypoplasia of the uterus (HP:0008684)1.61484787
146Postnatal microcephaly (HP:0005484)1.61461479
147Gout (HP:0001997)1.61325198
148Abnormal gallbladder morphology (HP:0012437)1.61123949
149Panhypogammaglobulinemia (HP:0003139)1.60942723
150Genital tract atresia (HP:0001827)1.59528337
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58470756
152Chronic sinusitis (HP:0011109)1.58325203
153Rough bone trabeculation (HP:0100670)1.58014788
154Abnormality of the heme biosynthetic pathway (HP:0010472)1.56967568
155B lymphocytopenia (HP:0010976)1.56783908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.40282764
2BUB14.23148175
3STK164.11069097
4NME13.26896680
5CASK3.22205493
6MAP3K123.13826352
7PBK2.70403805
8SIK32.52253341
9PDK22.34977563
10TESK12.19710470
11TSSK62.16368431
12IRAK32.11265394
13CDK191.99794822
14PNCK1.98150067
15MARK11.92066431
16ARAF1.89082526
17TESK21.87323499
18CCNB11.86561294
19DYRK21.84303256
20NEK11.83339805
21UHMK11.78122080
22VRK11.72623391
23NME21.72068592
24BCKDK1.72020994
25EIF2AK11.68580548
26GRK61.62014310
27TRIM281.61976683
28MAP2K71.61783068
29NTRK31.60533681
30MAPK131.52017397
31TTK1.50631775
32PASK1.50488784
33MUSK1.46149486
34PIM21.43992201
35GRK51.42491035
36ZAK1.36966708
37DAPK11.32303951
38MKNK11.32146163
39SMG11.31737637
40SIK21.29170223
41SRPK11.27610240
42EIF2AK31.24895221
43TNIK1.22886394
44LRRK21.22030609
45BRSK11.21376341
46BCR1.15965558
47ADRBK21.12917234
48CDK81.12160959
49MKNK21.11861779
50NTRK21.10464712
51SYK1.09998322
52TAOK21.09243678
53MAP4K11.07349366
54BRAF1.06090327
55WEE11.05785587
56TXK1.05304087
57PLK11.03393357
58AURKB1.01444962
59CSNK1G30.99334527
60PAK40.99238702
61NUAK10.98188417
62PLK20.97021498
63MAPKAPK50.94804528
64MINK10.92585282
65CAMK2B0.91517427
66PLK40.89127090
67DYRK1A0.88653324
68GRK70.87570212
69STK40.86739274
70ABL20.82877516
71LIMK10.82868528
72MAP3K40.82791926
73PRKD30.82616419
74KDR0.81987203
75FES0.81848231
76BLK0.81347648
77CDK11A0.81228972
78ATR0.81149929
79CDK180.81067019
80IRAK20.80429791
81BMPR1B0.79684127
82CHEK20.79133152
83AURKA0.78500986
84EPHA40.78224255
85MYLK0.75417205
86CDK150.74737213
87ALK0.74498760
88CDK140.69770539
89TLK10.69528982
90MAP3K110.68534672
91TBK10.68279990
92MAP3K80.68133567
93CDK70.67797467
94FGR0.67582322
95DYRK30.66482949
96PRKCG0.64952831
97PLK30.64140782
98PRKCI0.63781598
99EPHA20.63753964
100TGFBR10.63584150
101CHEK10.63397252
102WNK30.62588634
103MAPK40.61601794
104ADRBK10.60194222
105CAMK2A0.58458335
106MST40.57805970
107RPS6KB20.57728035
108AKT20.56299984
109YES10.55486127
110ILK0.55039125
111RPS6KA40.54952433
112CSNK2A20.54719331
113RPS6KA50.54120769
114MAP4K20.53242850
115PRPF4B0.53161458
116CDK50.52344577
117CSNK1G20.51888872
118RAF10.51456231
119OXSR10.51436348
120LYN0.50638123
121TNK20.50581158
122ZAP700.49588221
123IKBKB0.48599836
124ACVR1B0.47940164
125CSNK1G10.46911824
126CAMK2G0.46749068
127BTK0.46675658
128DAPK20.45264459
129CSF1R0.44980626
130DAPK30.44896155
131CDK30.44026312
132CSNK2A10.43808683
133AKT30.42853342
134MAPKAPK30.42368110
135STK100.40228365
136EIF2AK20.39252475
137CLK10.39195604
138CDC70.39123555
139MATK0.38951278
140CSNK1A1L0.38758181
141PAK10.38358838
142MAPK150.38339289
143PHKG10.38183629
144PHKG20.38183629
145MARK30.38150608
146MAP3K30.36774153
147CDK20.36467596
148LMTK20.35055612
149CDK10.33171803
150BMX0.32394931
151MAP2K20.32332306

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.36745546
2Proteasome_Homo sapiens_hsa030504.17952552
3Oxidative phosphorylation_Homo sapiens_hsa001904.07122827
4Parkinsons disease_Homo sapiens_hsa050123.57015001
5RNA polymerase_Homo sapiens_hsa030203.53096250
6Alzheimers disease_Homo sapiens_hsa050102.67614181
7Protein export_Homo sapiens_hsa030602.60625614
8Huntingtons disease_Homo sapiens_hsa050162.52857963
9* Spliceosome_Homo sapiens_hsa030402.40870850
10Nicotine addiction_Homo sapiens_hsa050332.37493602
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19400402
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09396868
13DNA replication_Homo sapiens_hsa030302.04970958
14Pyrimidine metabolism_Homo sapiens_hsa002401.96323915
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95733239
16Collecting duct acid secretion_Homo sapiens_hsa049661.88936601
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87672831
18Mismatch repair_Homo sapiens_hsa034301.85290970
19Synaptic vesicle cycle_Homo sapiens_hsa047211.82039899
20Biosynthesis of amino acids_Homo sapiens_hsa012301.71329665
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59297655
22Nucleotide excision repair_Homo sapiens_hsa034201.58057331
23Carbon metabolism_Homo sapiens_hsa012001.53606102
24Primary immunodeficiency_Homo sapiens_hsa053401.51991881
25RNA transport_Homo sapiens_hsa030131.43359491
26Phototransduction_Homo sapiens_hsa047441.42650733
27Vibrio cholerae infection_Homo sapiens_hsa051101.41503584
28Base excision repair_Homo sapiens_hsa034101.41428921
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39468346
30Glutathione metabolism_Homo sapiens_hsa004801.38830981
31GABAergic synapse_Homo sapiens_hsa047271.32507283
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.30982312
33Cardiac muscle contraction_Homo sapiens_hsa042601.27325026
34Purine metabolism_Homo sapiens_hsa002301.26367625
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24995318
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24856472
37Serotonergic synapse_Homo sapiens_hsa047261.24729659
38Pyruvate metabolism_Homo sapiens_hsa006201.24015340
39One carbon pool by folate_Homo sapiens_hsa006701.23388661
40Non-homologous end-joining_Homo sapiens_hsa034501.21573271
41Pentose phosphate pathway_Homo sapiens_hsa000301.20701956
42Fructose and mannose metabolism_Homo sapiens_hsa000511.19864776
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15752596
44Taste transduction_Homo sapiens_hsa047421.14842306
45Morphine addiction_Homo sapiens_hsa050321.14678085
46RNA degradation_Homo sapiens_hsa030181.12564977
47Homologous recombination_Homo sapiens_hsa034401.11931004
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10717626
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08231702
50Regulation of autophagy_Homo sapiens_hsa041401.03693493
51Basal transcription factors_Homo sapiens_hsa030221.01148272
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93132399
53Vitamin B6 metabolism_Homo sapiens_hsa007500.93071744
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90328868
55Galactose metabolism_Homo sapiens_hsa000520.89089868
56Amphetamine addiction_Homo sapiens_hsa050310.85383856
57Olfactory transduction_Homo sapiens_hsa047400.84018375
58Glutamatergic synapse_Homo sapiens_hsa047240.83944373
59Steroid biosynthesis_Homo sapiens_hsa001000.83375828
60Dopaminergic synapse_Homo sapiens_hsa047280.82473602
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80962921
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80505551
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79977491
64Circadian entrainment_Homo sapiens_hsa047130.78585164
65Other glycan degradation_Homo sapiens_hsa005110.75974092
66Epstein-Barr virus infection_Homo sapiens_hsa051690.74818705
67Rheumatoid arthritis_Homo sapiens_hsa053230.74534277
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73658989
69Alcoholism_Homo sapiens_hsa050340.72546460
70Sulfur metabolism_Homo sapiens_hsa009200.71141860
71Cocaine addiction_Homo sapiens_hsa050300.70574822
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66566039
73Type I diabetes mellitus_Homo sapiens_hsa049400.65382639
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64797988
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63958136
76mRNA surveillance pathway_Homo sapiens_hsa030150.63496451
77Cell cycle_Homo sapiens_hsa041100.62494054
78Arginine and proline metabolism_Homo sapiens_hsa003300.61250618
79Long-term potentiation_Homo sapiens_hsa047200.60374212
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59364050
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59230013
82Fanconi anemia pathway_Homo sapiens_hsa034600.57920039
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54644700
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.54603180
85Long-term depression_Homo sapiens_hsa047300.54346357
86Phagosome_Homo sapiens_hsa041450.54299614
87Autoimmune thyroid disease_Homo sapiens_hsa053200.52085535
88Cholinergic synapse_Homo sapiens_hsa047250.50789102
89Propanoate metabolism_Homo sapiens_hsa006400.49746070
90Calcium signaling pathway_Homo sapiens_hsa040200.49727613
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.49694498
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49099309
93Arginine biosynthesis_Homo sapiens_hsa002200.49013364
94Peroxisome_Homo sapiens_hsa041460.48862188
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48031430
96Fatty acid metabolism_Homo sapiens_hsa012120.42257128
97Oocyte meiosis_Homo sapiens_hsa041140.40265203
98Metabolic pathways_Homo sapiens_hsa011000.39635755
99Gap junction_Homo sapiens_hsa045400.39105109
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38872754
101Legionellosis_Homo sapiens_hsa051340.38673324
102African trypanosomiasis_Homo sapiens_hsa051430.38615688
103Phenylalanine metabolism_Homo sapiens_hsa003600.38335816
104Hematopoietic cell lineage_Homo sapiens_hsa046400.38225901
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36983806
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34436478
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34425602
108N-Glycan biosynthesis_Homo sapiens_hsa005100.33946490
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33097917
110Sulfur relay system_Homo sapiens_hsa041220.32761119
111Butanoate metabolism_Homo sapiens_hsa006500.32589916
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.32483527
113Salivary secretion_Homo sapiens_hsa049700.32471453
114Fatty acid elongation_Homo sapiens_hsa000620.31948140
115p53 signaling pathway_Homo sapiens_hsa041150.31651822
116Insulin secretion_Homo sapiens_hsa049110.31007206
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30831638
118Allograft rejection_Homo sapiens_hsa053300.30664355
119Shigellosis_Homo sapiens_hsa051310.28281790
120Herpes simplex infection_Homo sapiens_hsa051680.28078754
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27139047
122T cell receptor signaling pathway_Homo sapiens_hsa046600.24940027
123beta-Alanine metabolism_Homo sapiens_hsa004100.24791441
124Axon guidance_Homo sapiens_hsa043600.24662872
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24606635
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24227123
127Renin secretion_Homo sapiens_hsa049240.23975313
128Oxytocin signaling pathway_Homo sapiens_hsa049210.23755721
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.22672081
130Asthma_Homo sapiens_hsa053100.21870135
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.21568289
132Graft-versus-host disease_Homo sapiens_hsa053320.21102538
133Gastric acid secretion_Homo sapiens_hsa049710.20811027
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18286207
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17627276
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17166118
137Selenocompound metabolism_Homo sapiens_hsa004500.17114921
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16721391
139Folate biosynthesis_Homo sapiens_hsa007900.16409901
140Lysosome_Homo sapiens_hsa041420.16354851
141Antigen processing and presentation_Homo sapiens_hsa046120.15846766
142Systemic lupus erythematosus_Homo sapiens_hsa053220.15297889
143Tryptophan metabolism_Homo sapiens_hsa003800.13854059
144Tyrosine metabolism_Homo sapiens_hsa003500.13414287
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13233034
146Apoptosis_Homo sapiens_hsa042100.08864316
147Viral carcinogenesis_Homo sapiens_hsa052030.08840810
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07970811

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