PPY2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol esterification (GO:0010872)7.37242169
2regulation of phospholipase A2 activity (GO:0032429)7.36056953
3astrocyte differentiation (GO:0048708)6.20140181
4DNA damage induced protein phosphorylation (GO:0006975)6.18772176
5epithelial cell fate commitment (GO:0072148)5.86238238
6low-density lipoprotein particle remodeling (GO:0034374)5.43698400
7dorsal/ventral axis specification (GO:0009950)5.37066646
8water-soluble vitamin biosynthetic process (GO:0042364)5.33232104
9indolalkylamine metabolic process (GO:0006586)5.28955325
10regulation of acrosome reaction (GO:0060046)5.21398011
11ubiquinone metabolic process (GO:0006743)5.15171067
12regulation of cytokine production involved in inflammatory response (GO:1900015)5.03446142
13kidney morphogenesis (GO:0060993)4.99795523
14serotonin metabolic process (GO:0042428)4.96788852
15regulation of glucocorticoid secretion (GO:2000849)4.88032245
16primary amino compound metabolic process (GO:1901160)4.60316381
17fucose catabolic process (GO:0019317)4.54554238
18L-fucose metabolic process (GO:0042354)4.54554238
19L-fucose catabolic process (GO:0042355)4.54554238
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.49948849
21aldehyde catabolic process (GO:0046185)4.49419622
22regulation of autophagic vacuole assembly (GO:2000785)4.21825238
23ubiquinone biosynthetic process (GO:0006744)4.11242189
24mRNA cleavage (GO:0006379)4.10956156
25dopamine transport (GO:0015872)4.08072467
26protein-chromophore linkage (GO:0018298)4.07451372
27toxin metabolic process (GO:0009404)4.07228537
28nonmotile primary cilium assembly (GO:0035058)3.98035141
29positive regulation of steroid metabolic process (GO:0045940)3.94366269
30regulation of corticosteroid hormone secretion (GO:2000846)3.91154760
31digestion (GO:0007586)3.89106930
32response to dietary excess (GO:0002021)3.83584289
33negative regulation of cytosolic calcium ion concentration (GO:0051481)3.80046782
34indole-containing compound metabolic process (GO:0042430)3.79343868
35insulin secretion (GO:0030073)3.76090258
36positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.66160007
37early endosome to late endosome transport (GO:0045022)3.60664609
38glycerophospholipid catabolic process (GO:0046475)3.57779319
39tryptophan catabolic process (GO:0006569)3.55480585
40indole-containing compound catabolic process (GO:0042436)3.55480585
41indolalkylamine catabolic process (GO:0046218)3.55480585
42membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.47569748
43response to corticosterone (GO:0051412)3.40573202
44potassium ion import (GO:0010107)3.38389155
45response to insecticide (GO:0017085)3.35633847
46triglyceride homeostasis (GO:0070328)3.33763604
47acylglycerol homeostasis (GO:0055090)3.33763604
48quinone biosynthetic process (GO:1901663)3.32416591
49pancreas development (GO:0031016)3.30505362
50regulation of vacuole organization (GO:0044088)3.30252621
51positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.27982250
52negative regulation of circadian rhythm (GO:0042754)3.27846620
53dermatan sulfate biosynthetic process (GO:0030208)3.22165046
54entrainment of circadian clock by photoperiod (GO:0043153)3.19186200
55alkaloid metabolic process (GO:0009820)3.18359642
56regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.15254079
57type B pancreatic cell development (GO:0003323)3.13030066
58catecholamine transport (GO:0051937)3.12897433
59ER overload response (GO:0006983)3.10891768
60regulation of heart rate by cardiac conduction (GO:0086091)3.04065110
61regulation of Rac protein signal transduction (GO:0035020)3.03943560
62membrane repolarization during action potential (GO:0086011)3.02769642
63cell fate commitment involved in formation of primary germ layer (GO:0060795)3.00014180
64behavioral response to nicotine (GO:0035095)2.98801566
65brain morphogenesis (GO:0048854)2.97532946
66substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.95851299
67substrate-independent telencephalic tangential migration (GO:0021826)2.95851299
68axoneme assembly (GO:0035082)2.95496216
69plasma lipoprotein particle remodeling (GO:0034369)2.91773567
70protein-lipid complex remodeling (GO:0034368)2.91773567
71macromolecular complex remodeling (GO:0034367)2.91773567
72monoamine transport (GO:0015844)2.89049825
73regulation of DNA damage checkpoint (GO:2000001)2.87746943
74cardiac conduction (GO:0061337)2.87411051
75response to mineralocorticoid (GO:0051385)2.85103153
76dopamine biosynthetic process (GO:0042416)2.84685615
77regulation of lipoprotein metabolic process (GO:0050746)2.84356013
78estrogen biosynthetic process (GO:0006703)2.82954019
79dermatan sulfate metabolic process (GO:0030205)2.82379715
80photoperiodism (GO:0009648)2.80444464
81regulation of steroid hormone secretion (GO:2000831)2.78819777
82uronic acid metabolic process (GO:0006063)2.78379146
83glucuronate metabolic process (GO:0019585)2.78379146
84L-ascorbic acid metabolic process (GO:0019852)2.77811853
85regulation of calcium ion-dependent exocytosis (GO:0017158)2.74345307
86nephron epithelium morphogenesis (GO:0072088)2.72585409
87nephron tubule morphogenesis (GO:0072078)2.72585409
88aromatic amino acid family catabolic process (GO:0009074)2.72309730
89nodal signaling pathway (GO:0038092)2.71829782
90cardiac muscle adaptation (GO:0014887)2.71547165
91cardiac muscle hypertrophy in response to stress (GO:0014898)2.71547165
92muscle hypertrophy in response to stress (GO:0003299)2.71547165
93tryptophan metabolic process (GO:0006568)2.70981717
94negative regulation of appetite (GO:0032099)2.69526676
95negative regulation of response to food (GO:0032096)2.69526676
96regulation of synaptic transmission, dopaminergic (GO:0032225)2.68907063
97glandular epithelial cell development (GO:0002068)2.67839605
98cornea development in camera-type eye (GO:0061303)2.67400867
99induction of positive chemotaxis (GO:0050930)2.66575979
100positive regulation of protein homooligomerization (GO:0032464)2.66509228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.30573549
2TAF15_26573619_Chip-Seq_HEK293_Human4.45908992
3PIAS1_25552417_ChIP-Seq_VCAP_Human2.62042719
4ZNF274_21170338_ChIP-Seq_K562_Hela2.30372977
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25355298
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.02777657
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92209973
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91341157
9ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83737891
10GBX2_23144817_ChIP-Seq_PC3_Human1.68518492
11MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65904818
12ARNT_22903824_ChIP-Seq_MCF-7_Human1.64669990
13ER_23166858_ChIP-Seq_MCF-7_Human1.62262772
14IGF1R_20145208_ChIP-Seq_DFB_Human1.61970535
15LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61256356
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61239651
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59066872
18NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56903163
19TP53_22573176_ChIP-Seq_HFKS_Human1.54695513
20FUS_26573619_Chip-Seq_HEK293_Human1.53957739
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51028281
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.49034384
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48377136
24PHF8_20622853_ChIP-Seq_HELA_Human1.47139016
25VDR_22108803_ChIP-Seq_LS180_Human1.45839346
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45212049
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41537887
28AHR_22903824_ChIP-Seq_MCF-7_Human1.39854179
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.38467476
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38162728
31AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37052433
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35578893
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34805102
34AR_25329375_ChIP-Seq_VCAP_Human1.34471221
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27054004
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23378286
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20923541
38NFYA_21822215_ChIP-Seq_K562_Human1.20768780
39STAT3_23295773_ChIP-Seq_U87_Human1.20437970
40SMAD4_21799915_ChIP-Seq_A2780_Human1.19853306
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.19408797
42PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19379113
43P300_19829295_ChIP-Seq_ESCs_Human1.19328343
44BCAT_22108803_ChIP-Seq_LS180_Human1.18312650
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.17631589
46ETV1_20927104_ChIP-Seq_GIST48_Human1.17239466
47TCF4_23295773_ChIP-Seq_U87_Human1.17167472
48NFYB_21822215_ChIP-Seq_K562_Human1.17154982
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17010508
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16634672
51CDX2_22108803_ChIP-Seq_LS180_Human1.15896476
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14975318
53FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14158625
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12974994
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.12860256
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12089250
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11552650
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10823055
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10072588
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09364510
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09003281
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07922001
63SMAD3_21741376_ChIP-Seq_HESCs_Human1.05798187
64HOXB7_26014856_ChIP-Seq_BT474_Human1.05572918
65RUNX2_22187159_ChIP-Seq_PCA_Human1.05092977
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04740668
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04431070
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04397987
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.04303401
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03415070
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02889255
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.02250265
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02247738
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.01701749
75TBL1_22424771_ChIP-Seq_293T_Human1.01612291
76REST_21632747_ChIP-Seq_MESCs_Mouse1.01479903
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.01161828
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.00865471
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.00738330
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99015461
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98954170
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.98566446
83FOXA1_25552417_ChIP-Seq_VCAP_Human0.98121641
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97528223
85HNFA_21074721_ChIP-Seq_CACO-2_Human0.95803165
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95761352
87TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.95031279
88CMYC_18555785_Chip-Seq_ESCs_Mouse0.95026889
89AR_20517297_ChIP-Seq_VCAP_Human0.94921727
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93801115
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93300010
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.93027281
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92545903
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92128025
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91434446
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.91407643
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89634213
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89281567
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.88872079
100RBPJ_21746931_ChIP-Seq_IB4_Human0.88393265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.48370036
2MP0002638_abnormal_pupillary_reflex6.41492765
3MP0002909_abnormal_adrenal_gland3.56375763
4MP0000538_abnormal_urinary_bladder3.06662063
5MP0005379_endocrine/exocrine_gland_phen2.66441070
6MP0001502_abnormal_circadian_rhythm2.55984007
7MP0009046_muscle_twitch2.46324819
8MP0005365_abnormal_bile_salt2.38718902
9MP0004043_abnormal_pH_regulation2.34597648
10MP0003787_abnormal_imprinting2.27281356
11MP0001501_abnormal_sleep_pattern2.20506996
12MP0002693_abnormal_pancreas_physiology2.16033486
13MP0010386_abnormal_urinary_bladder2.09787034
14MP0001984_abnormal_olfaction2.09774769
15MP0005423_abnormal_somatic_nervous2.09435100
16MP0006276_abnormal_autonomic_nervous2.08803589
17MP0002876_abnormal_thyroid_physiology2.08401705
18MP0001944_abnormal_pancreas_morphology2.07579075
19MP0002163_abnormal_gland_morphology2.04422942
20MP0008961_abnormal_basal_metabolism1.78445372
21MP0009780_abnormal_chondrocyte_physiolo1.68859136
22MP0002733_abnormal_thermal_nociception1.63696371
23MP0005310_abnormal_salivary_gland1.62883102
24MP0001968_abnormal_touch/_nociception1.62404797
25MP0010329_abnormal_lipoprotein_level1.61367005
26MP0001756_abnormal_urination1.54953986
27MP0005085_abnormal_gallbladder_physiolo1.52888690
28MP0002837_dystrophic_cardiac_calcinosis1.50694513
29MP0005646_abnormal_pituitary_gland1.50299152
30MP0004019_abnormal_vitamin_homeostasis1.50212896
31MP0000013_abnormal_adipose_tissue1.48518089
32MP0005332_abnormal_amino_acid1.47607897
33MP0002138_abnormal_hepatobiliary_system1.43198334
34MP0002736_abnormal_nociception_after1.42699418
35MP0005535_abnormal_body_temperature1.39110500
36MP0001970_abnormal_pain_threshold1.36646473
37MP0005220_abnormal_exocrine_pancreas1.35681687
38MP0002078_abnormal_glucose_homeostasis1.33362940
39MP0000383_abnormal_hair_follicle1.28068837
40MP0004885_abnormal_endolymph1.26158796
41MP0008775_abnormal_heart_ventricle1.25652944
42MP0003283_abnormal_digestive_organ1.24784073
43MP0004085_abnormal_heartbeat1.19205014
44MP0001905_abnormal_dopamine_level1.15801316
45MP0005595_abnormal_vascular_smooth1.15630136
46MP0002272_abnormal_nervous_system1.14743909
47MP0002572_abnormal_emotion/affect_behav1.13951155
48MP0002139_abnormal_hepatobiliary_system1.13554009
49MP0008877_abnormal_DNA_methylation1.10412409
50MP0009745_abnormal_behavioral_response1.08287796
51MP0003137_abnormal_impulse_conducting1.06022426
52MP0002734_abnormal_mechanical_nocicepti1.05106001
53MP0000631_abnormal_neuroendocrine_gland1.03857907
54MP0001764_abnormal_homeostasis1.00716020
55MP0010678_abnormal_skin_adnexa1.00014639
56MP0002254_reproductive_system_inflammat0.95369483
57MP0003953_abnormal_hormone_level0.95081063
58MP0003646_muscle_fatigue0.94528582
59MP0001919_abnormal_reproductive_system0.93212815
60MP0005645_abnormal_hypothalamus_physiol0.92758914
61MP0001765_abnormal_ion_homeostasis0.92617474
62MP0000639_abnormal_adrenal_gland0.83964465
63MP0008995_early_reproductive_senescence0.83851510
64MP0005394_taste/olfaction_phenotype0.82764269
65MP0005499_abnormal_olfactory_system0.82764269
66MP0004215_abnormal_myocardial_fiber0.81612461
67MP0002557_abnormal_social/conspecific_i0.80802082
68MP0002069_abnormal_eating/drinking_beha0.80747328
69MP0002064_seizures0.79656904
70MP0003195_calcinosis0.77753037
71MP0006072_abnormal_retinal_apoptosis0.77537960
72MP0004924_abnormal_behavior0.76701514
73MP0005386_behavior/neurological_phenoty0.76701514
74MP0004145_abnormal_muscle_electrophysio0.75112976
75MP0002877_abnormal_melanocyte_morpholog0.73786650
76MP0006082_CNS_inflammation0.73251152
77MP0003121_genomic_imprinting0.71502202
78MP0002118_abnormal_lipid_homeostasis0.71111713
79MP0001661_extended_life_span0.70965457
80MP0000003_abnormal_adipose_tissue0.69524505
81MP0005389_reproductive_system_phenotype0.67052782
82MP0002063_abnormal_learning/memory/cond0.66958979
83MP0005551_abnormal_eye_electrophysiolog0.65973277
84MP0008873_increased_physiological_sensi0.64007049
85MP0008875_abnormal_xenobiotic_pharmacok0.63675768
86MP0004133_heterotaxia0.61990445
87MP0003252_abnormal_bile_duct0.60887946
88MP0004270_analgesia0.60440098
89MP0009643_abnormal_urine_homeostasis0.58900810
90MP0008057_abnormal_DNA_replication0.58046735
91MP0005253_abnormal_eye_physiology0.58014231
92MP0005620_abnormal_muscle_contractility0.57908653
93MP0003635_abnormal_synaptic_transmissio0.57215069
94MP0001664_abnormal_digestion0.57167575
95MP0000613_abnormal_salivary_gland0.55449114
96MP0008872_abnormal_physiological_respon0.53181134
97MP0003868_abnormal_feces_composition0.52947682
98MP0005448_abnormal_energy_balance0.51864022
99MP0003633_abnormal_nervous_system0.50655483
100MP0003011_delayed_dark_adaptation0.50078095

Predicted human phenotypes

RankGene SetZ-score
1Facial shape deformation (HP:0011334)6.86025516
2Potter facies (HP:0002009)6.86025516
3Mitral stenosis (HP:0001718)4.85549178
4Limb dystonia (HP:0002451)4.38643057
5Widely patent fontanelles and sutures (HP:0004492)4.20453001
6Prominent supraorbital ridges (HP:0000336)4.15510123
7Arthropathy (HP:0003040)4.11325917
8Cerebellar dysplasia (HP:0007033)3.97914148
9Type II lissencephaly (HP:0007260)3.92021626
10Diastasis recti (HP:0001540)3.82131438
11Severe muscular hypotonia (HP:0006829)3.73483190
12Mesangial abnormality (HP:0001966)3.68498084
13Hyperventilation (HP:0002883)3.64851246
14Decreased circulating renin level (HP:0003351)3.51120476
15Abnormal rod and cone electroretinograms (HP:0008323)3.27861082
16Tongue fasciculations (HP:0001308)3.25891475
17Distal arthrogryposis (HP:0005684)3.25184264
18Hypoglycemic coma (HP:0001325)3.14169551
19Hypothermia (HP:0002045)3.13370872
20Abnormality of renal excretion (HP:0011036)3.11940645
21Short hallux (HP:0010109)3.09736469
22Renal dysplasia (HP:0000110)3.08137770
23J-shaped sella turcica (HP:0002680)3.08052053
24Large for gestational age (HP:0001520)3.02878722
25Round ear (HP:0100830)2.96984163
26Vascular calcification (HP:0004934)2.95608483
27Hypotension (HP:0002615)2.92351015
28Wrist flexion contracture (HP:0001239)2.84572994
29Abnormal urine output (HP:0012590)2.84390842
30Muscle fibrillation (HP:0010546)2.82804853
31Aplasia/Hypoplasia of the hallux (HP:0008362)2.78785299
32Renal tubular acidosis (HP:0001947)2.76919241
33Medial flaring of the eyebrow (HP:0010747)2.72751132
34Proximal tubulopathy (HP:0000114)2.71977152
35Reduced antithrombin III activity (HP:0001976)2.71230904
36Abnormal cartilage morphology (HP:0002763)2.65509044
37Thickened helices (HP:0000391)2.65502223
38Glycosuria (HP:0003076)2.57149675
39Abnormality of urine glucose concentration (HP:0011016)2.57149675
40Cardiovascular calcification (HP:0011915)2.53496939
41Hypomagnesemia (HP:0002917)2.53004543
42Lissencephaly (HP:0001339)2.44082171
43Attenuation of retinal blood vessels (HP:0007843)2.41124835
44Exocrine pancreatic insufficiency (HP:0001738)2.40934920
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40223950
46Abnormality of alanine metabolism (HP:0010916)2.40223950
47Hyperalaninemia (HP:0003348)2.40223950
48Renal cortical cysts (HP:0000803)2.39371127
49Microretrognathia (HP:0000308)2.36108161
50Agitation (HP:0000713)2.35523831
51Abnormality of magnesium homeostasis (HP:0004921)2.33216458
52Generalized aminoaciduria (HP:0002909)2.31901347
53Insulin-resistant diabetes mellitus (HP:0000831)2.29901090
54Abnormal pupillary function (HP:0007686)2.28745997
55Bony spicule pigmentary retinopathy (HP:0007737)2.28733955
56Pancreatic fibrosis (HP:0100732)2.27472555
57Ketoacidosis (HP:0001993)2.26888347
58Hypoplasia of the fovea (HP:0007750)2.25595346
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.25595346
60Abnormality of the renal cortex (HP:0011035)2.19764131
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19134304
62Abnormality of the femoral head (HP:0003368)2.15870601
63Hyperinsulinemic hypoglycemia (HP:0000825)2.15640819
64Pancreatic cysts (HP:0001737)2.14776394
65Pachygyria (HP:0001302)2.12472747
66Difficulty running (HP:0009046)2.10429650
67Disproportionate short-trunk short stature (HP:0003521)2.07182320
68Nephronophthisis (HP:0000090)2.06605165
69Urethral obstruction (HP:0000796)2.04727760
70Nephrogenic diabetes insipidus (HP:0009806)2.02448629
71Multifactorial inheritance (HP:0001426)2.02182937
72Wide cranial sutures (HP:0010537)1.99737704
73Type I transferrin isoform profile (HP:0003642)1.97975212
74Barrel-shaped chest (HP:0001552)1.96467129
75CNS hypomyelination (HP:0003429)1.94988493
76Abnormal biliary tract physiology (HP:0012439)1.92385095
77Bile duct proliferation (HP:0001408)1.92385095
78Congenital primary aphakia (HP:0007707)1.91016554
79Metabolic alkalosis (HP:0200114)1.90765379
80Thin upper lip vermilion (HP:0000219)1.88683727
81Large eyes (HP:0001090)1.88381110
82Gait imbalance (HP:0002141)1.88231922
83Late onset (HP:0003584)1.85959363
84Joint swelling (HP:0001386)1.85176139
85Prolonged QT interval (HP:0001657)1.80805170
86Abnormality of the renal medulla (HP:0100957)1.79754221
87Abnormality of the vitreous humor (HP:0004327)1.77754081
88Absent epiphyses (HP:0010577)1.75036860
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75036860
90Cardiomegaly (HP:0001640)1.74977600
91Limb hypertonia (HP:0002509)1.73367948
92Choreoathetosis (HP:0001266)1.72939247
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72521711
94Menstrual irregularities (HP:0000858)1.71731414
95Abnormal pancreas size (HP:0012094)1.71073904
96Abolished electroretinogram (ERG) (HP:0000550)1.69957279
97Abnormality of vitamin B metabolism (HP:0004340)1.68199236
98Mixed hearing impairment (HP:0000410)1.67388120
99Preaxial foot polydactyly (HP:0001841)1.62632117
100Hemiparesis (HP:0001269)1.61993010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B5.29739043
2PIK3CG4.01623948
3ACVR1B3.98857998
4MAP3K63.72125186
5MAP3K43.29347120
6MAP2K72.89173105
7FRK2.84011643
8DAPK22.82234125
9PKN22.67442481
10TGFBR12.52855412
11ERN12.30718485
12ZAK2.25777381
13MAP2K62.20774597
14PNCK2.18345694
15CSNK1G12.04848458
16FLT31.94058983
17CSNK1G31.88192896
18CDK81.87608751
19PHKG21.72182383
20PHKG11.72182383
21TAOK31.68913413
22MAP4K21.60639247
23MAP2K41.58364547
24PDK21.54623226
25IRAK21.45384356
26RET1.45158272
27CSNK1G21.41679320
28ADRBK21.33168430
29MUSK1.25797088
30SGK21.22647482
31MST41.15741153
32GRK11.15361595
33BMX1.13749179
34MAP3K51.10035422
35MAP3K21.06037690
36PAK31.02635482
37LIMK11.01710551
38FGFR20.97316295
39MELK0.95122326
40SGK2230.92742357
41SGK4940.92742357
42AKT30.90174844
43PTK20.89066068
44PRKCE0.85367561
45NTRK30.82969662
46TESK10.79880071
47PINK10.79035469
48PIK3CA0.75263382
49RPS6KB10.74501313
50CDK90.74483170
51CDK120.73111878
52WNK40.72251626
53PRKCI0.71072456
54INSRR0.67529945
55STK240.66332629
56CASK0.65728748
57GSK3A0.59996804
58TAF10.57857664
59PRKAA10.57287132
60IRAK10.55167717
61ITK0.54990158
62SGK30.53683390
63SCYL20.50072717
64CAMK1G0.49859712
65PDK10.48724437
66FGFR10.47299070
67PRKCH0.45938366
68PRKCQ0.43661140
69NME10.43605314
70CSNK1A10.43432116
71HIPK20.42856609
72DAPK10.42475955
73MAP3K120.41672600
74MAP2K20.41292597
75PDPK10.40653346
76CAMK2D0.40409739
77PDGFRB0.38432608
78CSNK1E0.36762650
79LMTK20.35643544
80DMPK0.35380604
81MAPK150.34235257
82FER0.33163666
83PRKD20.32743828
84DAPK30.31629465
85PRKG10.31472897
86PRKG20.31460163
87MAP2K10.31260388
88TLK10.30794606
89RPS6KA20.30705745
90NLK0.30064997
91MAP3K70.29764903
92SGK10.28956766
93ROCK10.28544222
94TIE10.27917845
95ERBB30.27574749
96ADRBK10.27145559
97PRKACA0.26255175
98PRKCG0.24904023
99PBK0.24782934
100MKNK20.24619647

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.59051604
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.55223544
3Tryptophan metabolism_Homo sapiens_hsa003803.28418517
4Circadian rhythm_Homo sapiens_hsa047102.69881539
5Renin-angiotensin system_Homo sapiens_hsa046142.67372460
6Cocaine addiction_Homo sapiens_hsa050302.46146208
7Butanoate metabolism_Homo sapiens_hsa006502.32815384
8Folate biosynthesis_Homo sapiens_hsa007902.25644573
9Insulin secretion_Homo sapiens_hsa049112.17670428
10Amphetamine addiction_Homo sapiens_hsa050312.13474054
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13368211
12Mineral absorption_Homo sapiens_hsa049782.07564971
13Sulfur metabolism_Homo sapiens_hsa009202.01615352
14Nitrogen metabolism_Homo sapiens_hsa009101.98158819
15Serotonergic synapse_Homo sapiens_hsa047261.80724549
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74188067
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66222067
18Renin secretion_Homo sapiens_hsa049241.61591777
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58907428
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.55767009
21Type II diabetes mellitus_Homo sapiens_hsa049301.52557640
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48263766
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43501509
24Pancreatic secretion_Homo sapiens_hsa049721.39095642
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38006517
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34900814
27beta-Alanine metabolism_Homo sapiens_hsa004101.32263041
28ABC transporters_Homo sapiens_hsa020101.24997123
29Dopaminergic synapse_Homo sapiens_hsa047281.22748666
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21697641
31Propanoate metabolism_Homo sapiens_hsa006401.21160569
32N-Glycan biosynthesis_Homo sapiens_hsa005101.19936857
33Bile secretion_Homo sapiens_hsa049761.19161507
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19068620
35Ovarian steroidogenesis_Homo sapiens_hsa049131.14463864
36Protein export_Homo sapiens_hsa030601.14045177
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13253695
38Selenocompound metabolism_Homo sapiens_hsa004501.11815248
39Fatty acid degradation_Homo sapiens_hsa000711.10898418
40Caffeine metabolism_Homo sapiens_hsa002321.09434859
41Linoleic acid metabolism_Homo sapiens_hsa005911.06703376
42Synaptic vesicle cycle_Homo sapiens_hsa047211.06178039
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05178628
44Taste transduction_Homo sapiens_hsa047421.04869647
45Salivary secretion_Homo sapiens_hsa049701.03978564
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02679997
47Cardiac muscle contraction_Homo sapiens_hsa042600.95963160
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93978353
49Thyroid hormone synthesis_Homo sapiens_hsa049180.91466358
50Circadian entrainment_Homo sapiens_hsa047130.88676554
51Phenylalanine metabolism_Homo sapiens_hsa003600.87160321
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79603689
53Histidine metabolism_Homo sapiens_hsa003400.79223260
54Oxidative phosphorylation_Homo sapiens_hsa001900.79108847
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.78303802
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78274936
57RNA degradation_Homo sapiens_hsa030180.77989562
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76919742
59Starch and sucrose metabolism_Homo sapiens_hsa005000.76159183
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.72851735
61Regulation of autophagy_Homo sapiens_hsa041400.72838462
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71970238
63TGF-beta signaling pathway_Homo sapiens_hsa043500.71083252
64Fatty acid metabolism_Homo sapiens_hsa012120.70007391
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69590782
66Basal transcription factors_Homo sapiens_hsa030220.66869716
67Nicotine addiction_Homo sapiens_hsa050330.66174393
68Parkinsons disease_Homo sapiens_hsa050120.65492812
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62277238
70PPAR signaling pathway_Homo sapiens_hsa033200.61867841
71GABAergic synapse_Homo sapiens_hsa047270.61348792
72Calcium signaling pathway_Homo sapiens_hsa040200.59287203
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57509619
74Fat digestion and absorption_Homo sapiens_hsa049750.53581555
75Peroxisome_Homo sapiens_hsa041460.51994027
76Collecting duct acid secretion_Homo sapiens_hsa049660.50720475
77mTOR signaling pathway_Homo sapiens_hsa041500.49958142
78Olfactory transduction_Homo sapiens_hsa047400.48324936
79Ether lipid metabolism_Homo sapiens_hsa005650.47630549
80Tyrosine metabolism_Homo sapiens_hsa003500.47315918
81Chemical carcinogenesis_Homo sapiens_hsa052040.46356493
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45749235
83Metabolic pathways_Homo sapiens_hsa011000.44947981
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44737524
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44333846
86Type I diabetes mellitus_Homo sapiens_hsa049400.43127708
87Phototransduction_Homo sapiens_hsa047440.42506717
88Sulfur relay system_Homo sapiens_hsa041220.41000752
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40792707
90Prion diseases_Homo sapiens_hsa050200.39603795
91Vibrio cholerae infection_Homo sapiens_hsa051100.39263989
92Gastric acid secretion_Homo sapiens_hsa049710.39223078
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37569094
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37415875
95Dorso-ventral axis formation_Homo sapiens_hsa043200.37275863
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36785723
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35455892
98Vitamin B6 metabolism_Homo sapiens_hsa007500.34259549
99Cholinergic synapse_Homo sapiens_hsa047250.33968837
100Glucagon signaling pathway_Homo sapiens_hsa049220.33165453

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