PPY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.59376195
2Golgi transport vesicle coating (GO:0048200)9.59376195
3regulation of phospholipase A2 activity (GO:0032429)7.13585217
4regulation of cholesterol esterification (GO:0010872)6.82802267
5endocrine pancreas development (GO:0031018)6.30720163
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.29691479
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.22683503
8peptide hormone processing (GO:0016486)6.03619635
9dorsal/ventral axis specification (GO:0009950)5.71762470
10type B pancreatic cell development (GO:0003323)5.68278005
11glandular epithelial cell differentiation (GO:0002067)5.59379876
12protein retention in ER lumen (GO:0006621)5.57354068
13low-density lipoprotein particle remodeling (GO:0034374)5.54056004
14glandular epithelial cell development (GO:0002068)5.16556709
15regulation of acrosome reaction (GO:0060046)5.09895082
16COPII vesicle coating (GO:0048208)4.99080007
17L-alpha-amino acid transmembrane transport (GO:1902475)4.92947541
18insulin secretion (GO:0030073)4.90646383
19positive regulation of insulin secretion (GO:0032024)4.74589003
20regulation of type B pancreatic cell apoptotic process (GO:2000674)4.70505781
21adhesion of symbiont to host cell (GO:0044650)4.67046949
22virion attachment to host cell (GO:0019062)4.67046949
23brain morphogenesis (GO:0048854)4.62524860
24epithelial cell fate commitment (GO:0072148)4.54364370
25cellular response to vitamin D (GO:0071305)4.53792434
26water-soluble vitamin biosynthetic process (GO:0042364)4.51452176
27polarized epithelial cell differentiation (GO:0030859)4.51290807
28signal peptide processing (GO:0006465)4.48623715
29positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.47240665
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.44357862
31glycerophospholipid catabolic process (GO:0046475)4.42211815
32vesicle coating (GO:0006901)4.39146130
33negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.36461329
34protein maturation by protein folding (GO:0022417)4.35476401
35ncRNA 3-end processing (GO:0043628)4.30828564
36inner ear receptor cell differentiation (GO:0060113)4.29949253
37nucleotide transmembrane transport (GO:1901679)4.28986525
38serotonin metabolic process (GO:0042428)4.25220874
39positive regulation of nuclease activity (GO:0032075)4.21770896
40indolalkylamine metabolic process (GO:0006586)4.19623640
41L-fucose catabolic process (GO:0042355)4.12116010
42fucose catabolic process (GO:0019317)4.12116010
43L-fucose metabolic process (GO:0042354)4.12116010
44negative regulation of cytosolic calcium ion concentration (GO:0051481)4.05668506
45xenobiotic catabolic process (GO:0042178)4.03275512
46exocrine pancreas development (GO:0031017)4.01928038
47regulation of insulin secretion (GO:0050796)4.01363362
48transcytosis (GO:0045056)4.01197812
49columnar/cuboidal epithelial cell development (GO:0002066)4.00639756
50positive regulation of steroid metabolic process (GO:0045940)3.99060759
51auditory receptor cell differentiation (GO:0042491)3.92207552
52endocrine process (GO:0050886)3.86851012
53regulation of systemic arterial blood pressure by hormone (GO:0001990)3.86851012
54regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.86851012
55nonmotile primary cilium assembly (GO:0035058)3.86400013
56toxin metabolic process (GO:0009404)3.86078301
57regulation of Rac protein signal transduction (GO:0035020)3.83632596
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.82724461
59regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.82432133
60macroautophagy (GO:0016236)3.82250816
61positive regulation of peptide hormone secretion (GO:0090277)3.81885745
62regulation of nuclease activity (GO:0032069)3.81556184
63primary amino compound metabolic process (GO:1901160)3.78673937
64potassium ion import (GO:0010107)3.76899456
65nitric oxide mediated signal transduction (GO:0007263)3.76076568
66regulation of autophagic vacuole assembly (GO:2000785)3.75413764
67detection of calcium ion (GO:0005513)3.74709343
68inositol phosphate dephosphorylation (GO:0046855)3.72453073
69phosphorylated carbohydrate dephosphorylation (GO:0046838)3.72453073
70RNA destabilization (GO:0050779)3.70794290
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70592911
72adhesion of symbiont to host (GO:0044406)3.70021851
73positive regulation of peptide secretion (GO:0002793)3.69602578
74peptide hormone secretion (GO:0030072)3.68813769
75intra-Golgi vesicle-mediated transport (GO:0006891)3.65500068
76endoplasmic reticulum unfolded protein response (GO:0030968)3.64832511
77phenylpropanoid metabolic process (GO:0009698)3.63500898
78inositol phosphate catabolic process (GO:0071545)3.62812784
79negative regulation of JUN kinase activity (GO:0043508)3.62476813
80regulation of peptide hormone secretion (GO:0090276)3.61460701
81peptide secretion (GO:0002790)3.60161522
82ER-nucleus signaling pathway (GO:0006984)3.59275894
83cellular response to unfolded protein (GO:0034620)3.57538462
84cellular response to hepatocyte growth factor stimulus (GO:0035729)3.56824999
85response to hepatocyte growth factor (GO:0035728)3.56824999
86regulation of peptide secretion (GO:0002791)3.55039679
87thalamus development (GO:0021794)3.54568125
88negative regulation of glycoprotein biosynthetic process (GO:0010561)3.53856484
89axoneme assembly (GO:0035082)3.53513472
90protein autoprocessing (GO:0016540)3.51093475
91negative regulation of execution phase of apoptosis (GO:1900118)3.50279031
92cellular response to topologically incorrect protein (GO:0035967)3.44017685
93membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.43582349
94regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.43400844
95sequestering of metal ion (GO:0051238)3.42113482
96establishment of apical/basal cell polarity (GO:0035089)3.39091974
97positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.36057591
98regulation of Golgi to plasma membrane protein transport (GO:0042996)3.35000273
99cerebellar Purkinje cell layer development (GO:0021680)3.34824088
100positive regulation of calcium ion import (GO:0090280)3.33781345
101positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.32510536
102DNA damage induced protein phosphorylation (GO:0006975)3.32168169
103regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.30989010
104ER overload response (GO:0006983)3.30553892
105astrocyte differentiation (GO:0048708)3.29660116
106positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.27783971
107plasma lipoprotein particle remodeling (GO:0034369)3.27385991
108protein-lipid complex remodeling (GO:0034368)3.27385991
109macromolecular complex remodeling (GO:0034367)3.27385991
110regulation of sequestering of triglyceride (GO:0010889)3.25281345
111cellular response to glucagon stimulus (GO:0071377)3.24283007
112regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.21089667
113regulation of synaptic transmission, dopaminergic (GO:0032225)3.20726258
114reflex (GO:0060004)3.19693972
115monoamine transport (GO:0015844)3.18743907
116regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.17310464
117protein targeting to Golgi (GO:0000042)3.16081494
118regulation of response to food (GO:0032095)3.15365290
119drinking behavior (GO:0042756)3.15352822
120intestinal cholesterol absorption (GO:0030299)3.13833222
121chemosensory behavior (GO:0007635)3.13045503
122mRNA modification (GO:0016556)3.13032225
123potassium ion export (GO:0071435)3.12732061
124positive regulation of vesicle fusion (GO:0031340)3.11557194
125positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.11487747
126regulation of calcium ion-dependent exocytosis (GO:0017158)3.10971122
127ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.09495037
128regulation of hormone secretion (GO:0046883)3.09096243
129cellular response to vitamin (GO:0071295)3.07634299
130regulation of vacuole organization (GO:0044088)3.06590193
131polyol catabolic process (GO:0046174)3.05485027
132response to endoplasmic reticulum stress (GO:0034976)3.03570374
133regulation of heart rate by cardiac conduction (GO:0086091)3.02849182
134protein localization to Golgi apparatus (GO:0034067)3.02449474
135membrane repolarization during action potential (GO:0086011)3.02395468
136indole-containing compound metabolic process (GO:0042430)3.02185611
137L-phenylalanine catabolic process (GO:0006559)3.01316593
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.01316593
139regulation of systemic arterial blood pressure (GO:0003073)3.00428834
140benzene-containing compound metabolic process (GO:0042537)3.00086732
141response to ischemia (GO:0002931)2.99943492
142pancreas development (GO:0031016)2.97407562
143positive regulation of glycoprotein metabolic process (GO:1903020)2.97050446
144positive regulation of hormone secretion (GO:0046887)2.96659063
145establishment or maintenance of monopolar cell polarity (GO:0061339)2.95240659
146establishment of monopolar cell polarity (GO:0061162)2.95240659
147regulation of protein glycosylation (GO:0060049)2.94032645
148phosphatidylethanolamine biosynthetic process (GO:0006646)2.93960690
149negative regulation of response to food (GO:0032096)2.92829164
150negative regulation of appetite (GO:0032099)2.92829164
151hormone secretion (GO:0046879)2.92289800
152negative regulation of digestive system process (GO:0060457)2.91770894
153response to dietary excess (GO:0002021)2.91741201
154regulation of peptide transport (GO:0090087)2.91515318
155positive regulation of hormone biosynthetic process (GO:0046886)2.89601234
156regulation of glucocorticoid secretion (GO:2000849)2.88754801
157cellular ketone body metabolic process (GO:0046950)2.88230489
158cornea development in camera-type eye (GO:0061303)2.86772625
159nephron tubule morphogenesis (GO:0072078)2.86396971
160nephron epithelium morphogenesis (GO:0072088)2.86396971
161mechanosensory behavior (GO:0007638)2.85960148
162cardiac muscle hypertrophy in response to stress (GO:0014898)2.84791345
163muscle hypertrophy in response to stress (GO:0003299)2.84791345
164cardiac muscle adaptation (GO:0014887)2.84791345
165early endosome to late endosome transport (GO:0045022)2.81464316
166positive regulation of neurological system process (GO:0031646)2.75905576
167regulation of cell proliferation involved in kidney development (GO:1901722)2.75310879
168aromatic amino acid family catabolic process (GO:0009074)2.72760163
169epithelial cilium movement (GO:0003351)2.71179888
170artery smooth muscle contraction (GO:0014824)2.69150001
171mechanoreceptor differentiation (GO:0042490)2.68675243
172eosinophil chemotaxis (GO:0048245)2.68414853
173regulation of vasoconstriction (GO:0019229)2.68389189
174dentate gyrus development (GO:0021542)2.67866905
175cardiac conduction (GO:0061337)2.67626811
176cellular response to gonadotropin stimulus (GO:0071371)2.67321010
177response to pheromone (GO:0019236)2.66572720
178phosphatidylethanolamine metabolic process (GO:0046337)2.62258865
179dopamine transport (GO:0015872)2.61437558
180L-phenylalanine metabolic process (GO:0006558)2.60507725
181erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.60507725
182aromatic amino acid family metabolic process (GO:0009072)2.59585947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF15_26573619_Chip-Seq_HEK293_Human3.89162525
2GATA1_22025678_ChIP-Seq_K562_Human3.17047571
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.82363872
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55175981
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.46133231
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.43125257
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38893172
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30680049
9FUS_26573619_Chip-Seq_HEK293_Human2.19146092
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.16986016
11GBX2_23144817_ChIP-Seq_PC3_Human2.16754463
12ZNF263_19887448_ChIP-Seq_K562_Human2.11482212
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03603527
14ER_23166858_ChIP-Seq_MCF-7_Human2.02647685
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.4864071
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82495891
17P300_19829295_ChIP-Seq_ESCs_Human1.77421784
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76561826
19IGF1R_20145208_ChIP-Seq_DFB_Human1.75286373
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70322499
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68988350
22REST_21632747_ChIP-Seq_MESCs_Mouse1.65719803
23AR_25329375_ChIP-Seq_VCAP_Human1.65302814
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65222437
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64399707
26SMAD3_21741376_ChIP-Seq_EPCs_Human1.62797199
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60502686
28NFIB_24661679_ChIP-Seq_LUNG_Mouse1.59059825
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57601543
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54705007
31GATA1_19941826_ChIP-Seq_K562_Human1.52877505
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.52599926
33RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52371213
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.50560541
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49014866
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47542954
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46288381
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44802059
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44316087
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44131369
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43109955
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41470990
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40331811
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.40190298
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.39283431
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38341835
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37896059
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35835090
49ZNF274_21170338_ChIP-Seq_K562_Hela1.32953888
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31450236
51EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29908687
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.29691083
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29197438
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28623922
55CDX2_22108803_ChIP-Seq_LS180_Human1.27702250
56FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27267877
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27255091
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27051361
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26078325
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22531005
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21574933
62STAT3_23295773_ChIP-Seq_U87_Human1.20764482
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20604664
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20329677
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.19892623
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19609385
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19311959
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18544286
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17152912
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.15613183
71VDR_22108803_ChIP-Seq_LS180_Human1.15328139
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.14883772
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14847100
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.14208494
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14133222
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14133222
77EZH2_22144423_ChIP-Seq_EOC_Human1.13867664
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.13431557
79EWS_26573619_Chip-Seq_HEK293_Human1.11649617
80HTT_18923047_ChIP-ChIP_STHdh_Human1.11625727
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.11590496
82FOXA1_25552417_ChIP-Seq_VCAP_Human1.10896559
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10425585
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10393322
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09823835
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.09016112
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08672053
88P53_22387025_ChIP-Seq_ESCs_Mouse1.08385135
89RUNX2_22187159_ChIP-Seq_PCA_Human1.07263233
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06804115
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.04566952
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04511756
93IRF1_19129219_ChIP-ChIP_H3396_Human1.04448616
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.03739690
95PHF8_20622853_ChIP-Seq_HELA_Human1.03392954
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.03211280
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03044663
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02843142
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.01593080
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.01155264
101TBL1_22424771_ChIP-Seq_293T_Human1.00958206
102* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00683236
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.00460073
104SOX2_19829295_ChIP-Seq_ESCs_Human1.00224214
105NANOG_19829295_ChIP-Seq_ESCs_Human1.00224214
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99502884
107SMAD4_21799915_ChIP-Seq_A2780_Human0.99156554
108STAT3_18555785_Chip-Seq_ESCs_Mouse0.98451107
109FOXA2_19822575_ChIP-Seq_HepG2_Human0.98304013
110TCF4_22108803_ChIP-Seq_LS180_Human0.98174105
111KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97889585
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97415298
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97017510
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96917094
115REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96289704
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96283918
117NMYC_18555785_Chip-Seq_ESCs_Mouse0.95881520
118AHR_22903824_ChIP-Seq_MCF-7_Human0.95107180
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94786031
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94786031
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94596223
122* CREB1_26743006_Chip-Seq_LNCaP_Human0.94509098
123PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93854612
124SOX2_20726797_ChIP-Seq_SW620_Human0.93666715
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92446517
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.92424892
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92273550
128AR_19668381_ChIP-Seq_PC3_Human0.91755831
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91693566
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91333139
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90971345
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90067395
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.89691392
134TCF4_23295773_ChIP-Seq_U87_Human0.89082952
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88775041
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87911696
137DROSHA_22980978_ChIP-Seq_HELA_Human0.87721222
138SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85819887
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.85524058
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.84631639
141TP53_22573176_ChIP-Seq_HFKS_Human0.84273705
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82623754
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.80360607
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.80360607
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80147759
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80049049
147PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78282327
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77753636
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.77663865
150* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77229449
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75326063
152LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73800961
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.73301729
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72737047
155EP300_21415370_ChIP-Seq_HL-1_Mouse0.72556754
156BCAT_22108803_ChIP-Seq_LS180_Human0.72000412
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71750195
158POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71693689
159FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70806088
160EZH2_27304074_Chip-Seq_ESCs_Mouse0.70789976
161LXR_22292898_ChIP-Seq_THP-1_Human0.69655758
162CTBP2_25329375_ChIP-Seq_LNCAP_Human0.69308676
163FLI1_21867929_ChIP-Seq_TH2_Mouse0.68490545
164FOXA1_21572438_ChIP-Seq_LNCaP_Human0.67901369
165PPARA_22158963_ChIP-Seq_LIVER_Mouse0.67879441
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.67872184
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.67838474
168EED_16625203_ChIP-ChIP_MESCs_Mouse0.67323595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue6.36305536
2MP0003183_abnormal_peptide_metabolism5.27358205
3MP0002877_abnormal_melanocyte_morpholog4.67091429
4MP0003195_calcinosis4.54361136
5MP0002909_abnormal_adrenal_gland4.08906578
6MP0005645_abnormal_hypothalamus_physiol3.56097573
7MP0003283_abnormal_digestive_organ3.52603933
8MP0001944_abnormal_pancreas_morphology3.52422596
9MP0002693_abnormal_pancreas_physiology3.43637675
10MP0010386_abnormal_urinary_bladder3.33060926
11MP0005379_endocrine/exocrine_gland_phen3.31313503
12MP0000003_abnormal_adipose_tissue3.27476647
13MP0001501_abnormal_sleep_pattern3.27170304
14MP0004043_abnormal_pH_regulation3.27077363
15MP0009780_abnormal_chondrocyte_physiolo3.18974578
16MP0000678_abnormal_parathyroid_gland2.98184880
17MP0002837_dystrophic_cardiac_calcinosis2.63531953
18MP0005220_abnormal_exocrine_pancreas2.57887528
19MP0005310_abnormal_salivary_gland2.46179054
20MP0009046_muscle_twitch2.45356957
21MP0003646_muscle_fatigue2.34008264
22MP0001984_abnormal_olfaction2.31849790
23MP0008775_abnormal_heart_ventricle2.25239417
24MP0004270_analgesia2.21647782
25MP0005423_abnormal_somatic_nervous2.20582822
26MP0003172_abnormal_lysosome_physiology2.10744319
27MP0002078_abnormal_glucose_homeostasis2.08662433
28MP0000383_abnormal_hair_follicle2.07029126
29MP0002254_reproductive_system_inflammat2.03761999
30MP0004264_abnormal_extraembryonic_tissu2.02540751
31MP0001502_abnormal_circadian_rhythm1.97957762
32MP0010678_abnormal_skin_adnexa1.91399149
33MP0002234_abnormal_pharynx_morphology1.87009969
34MP0004019_abnormal_vitamin_homeostasis1.79312188
35MP0002638_abnormal_pupillary_reflex1.77201830
36MP0003122_maternal_imprinting1.73847111
37MP0003300_gastrointestinal_ulcer1.69725994
38MP0008877_abnormal_DNA_methylation1.67953185
39MP0001765_abnormal_ion_homeostasis1.63789516
40MP0001764_abnormal_homeostasis1.61498383
41MP0006072_abnormal_retinal_apoptosis1.61357010
42MP0002896_abnormal_bone_mineralization1.60620511
43MP0002138_abnormal_hepatobiliary_system1.56557452
44MP0006276_abnormal_autonomic_nervous1.54448605
45MP0003959_abnormal_lean_body1.50869465
46MP0005375_adipose_tissue_phenotype1.49168596
47MP0003941_abnormal_skin_development1.45612708
48MP0005085_abnormal_gallbladder_physiolo1.45246655
49MP0005365_abnormal_bile_salt1.44925727
50MP0003011_delayed_dark_adaptation1.42220532
51MP0002272_abnormal_nervous_system1.38334651
52MP0008057_abnormal_DNA_replication1.34986625
53MP0005360_urolithiasis1.33748007
54MP0001661_extended_life_span1.31367428
55MP0004215_abnormal_myocardial_fiber1.30623921
56MP0001986_abnormal_taste_sensitivity1.29840824
57MP0001756_abnormal_urination1.28056531
58MP0003787_abnormal_imprinting1.26538068
59MP0003252_abnormal_bile_duct1.26308778
60MP0010329_abnormal_lipoprotein_level1.25522943
61MP0003953_abnormal_hormone_level1.23994361
62MP0000613_abnormal_salivary_gland1.21539734
63MP0004885_abnormal_endolymph1.20888225
64MP0003868_abnormal_feces_composition1.20148045
65MP0009643_abnormal_urine_homeostasis1.17396405
66MP0008961_abnormal_basal_metabolism1.17134952
67MP0004145_abnormal_muscle_electrophysio1.14822070
68MP0005595_abnormal_vascular_smooth1.13852591
69MP0005332_abnormal_amino_acid1.13362100
70MP0003137_abnormal_impulse_conducting1.12873932
71MP0003123_paternal_imprinting1.08999033
72MP0003786_premature_aging1.07376240
73MP0005084_abnormal_gallbladder_morpholo1.04988514
74MP0001958_emphysema1.04190764
75MP0002163_abnormal_gland_morphology1.03566610
76MP0002572_abnormal_emotion/affect_behav1.01660303
77MP0002971_abnormal_brown_adipose1.01392086
78MP0000631_abnormal_neuroendocrine_gland1.00624963
79MP0002928_abnormal_bile_duct1.00418942
80MP0004133_heterotaxia0.99841549
81MP0003045_fibrosis0.99702956
82MP0002734_abnormal_mechanical_nocicepti0.98871887
83MP0000230_abnormal_systemic_arterial0.98526169
84MP0009745_abnormal_behavioral_response0.98482328
85MP0003879_abnormal_hair_cell0.97955713
86MP0000372_irregular_coat_pigmentation0.96808191
87MP0003119_abnormal_digestive_system0.94977255
88MP0000427_abnormal_hair_cycle0.94288340
89MP0005620_abnormal_muscle_contractility0.93563381
90MP0010234_abnormal_vibrissa_follicle0.92720418
91MP0002876_abnormal_thyroid_physiology0.91408333
92MP0000639_abnormal_adrenal_gland0.89584251
93MP0001299_abnormal_eye_distance/0.88549650
94MP0001919_abnormal_reproductive_system0.86751850
95MP0002938_white_spotting0.86128265
96MP0006054_spinal_hemorrhage0.85316504
97MP0003121_genomic_imprinting0.83302567
98MP0005636_abnormal_mineral_homeostasis0.82826286
99MP0005551_abnormal_eye_electrophysiolog0.82764180
100MP0005646_abnormal_pituitary_gland0.78542247
101MP0000538_abnormal_urinary_bladder0.78267390
102MP0001270_distended_abdomen0.78132638
103MP0002127_abnormal_cardiovascular_syste0.78096598
104MP0001666_abnormal_nutrient_absorption0.77909095
105MP0002064_seizures0.77834245
106MP0001968_abnormal_touch/_nociception0.75548164
107MP0006082_CNS_inflammation0.74482219
108MP0005535_abnormal_body_temperature0.72590706
109MP0008875_abnormal_xenobiotic_pharmacok0.72303312
110MP0005058_abnormal_lysosome_morphology0.71434617
111MP0005389_reproductive_system_phenotype0.71124424
112MP0005330_cardiomyopathy0.70995148
113MP0002229_neurodegeneration0.69521037
114MP0005076_abnormal_cell_differentiation0.69109451
115MP0002139_abnormal_hepatobiliary_system0.67336762
116MP0005386_behavior/neurological_phenoty0.67051668
117MP0004924_abnormal_behavior0.67051668
118MP0003186_abnormal_redox_activity0.66601981
119MP0005257_abnormal_intraocular_pressure0.65986995
120MP0000462_abnormal_digestive_system0.65759317
121MP0005334_abnormal_fat_pad0.64369123
122MP0002168_other_aberrant_phenotype0.61462097
123MP0001188_hyperpigmentation0.61229441
124MP0002751_abnormal_autonomic_nervous0.59105904
125MP0001664_abnormal_digestion0.59017095
126MP0005408_hypopigmentation0.57794118
127MP0005448_abnormal_energy_balance0.57604023
128MP0005670_abnormal_white_adipose0.57526890
129MP0002177_abnormal_outer_ear0.57051121
130MP0004085_abnormal_heartbeat0.56402218
131MP0000428_abnormal_craniofacial_morphol0.55621222
132MP0002069_abnormal_eating/drinking_beha0.55111734
133MP0002733_abnormal_thermal_nociception0.54892421
134MP0001485_abnormal_pinna_reflex0.53760085
135MP0000681_abnormal_thyroid_gland0.51472451
136MP0000955_abnormal_spinal_cord0.49793382
137MP0009642_abnormal_blood_homeostasis0.49510676
138MP0002118_abnormal_lipid_homeostasis0.49272490
139MP0005253_abnormal_eye_physiology0.47624910
140MP0005452_abnormal_adipose_tissue0.47620613
141MP0001879_abnormal_lymphatic_vessel0.47440687
142MP0003633_abnormal_nervous_system0.46209417
143MP0009672_abnormal_birth_weight0.45417225
144MP0002009_preneoplasia0.45384988
145MP0003638_abnormal_response/metabolism_0.45155474
146MP0004130_abnormal_muscle_cell0.43905289
147MP0001970_abnormal_pain_threshold0.42583538
148MP0000470_abnormal_stomach_morphology0.41996839
149MP0004036_abnormal_muscle_relaxation0.41896298
150MP0005248_abnormal_Harderian_gland0.41454908

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.90393178
2Facial shape deformation (HP:0011334)7.85880136
3Potter facies (HP:0002009)7.85880136
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.75895450
5Hypoglycemic seizures (HP:0002173)7.01442231
6Symptomatic seizures (HP:0011145)6.09744303
7Hyperglycemia (HP:0003074)5.78313334
8Hypoglycemic coma (HP:0001325)5.54881562
9Vascular calcification (HP:0004934)5.42849306
10Pancreatic islet-cell hyperplasia (HP:0004510)5.37397164
11Abnormality of calcium-phosphate metabolism (HP:0100530)5.33067061
12Insulin-resistant diabetes mellitus (HP:0000831)5.03738077
13Abnormality of endocrine pancreas physiology (HP:0012093)4.95812008
14Abnormality of the pancreatic islet cells (HP:0006476)4.95812008
15Large for gestational age (HP:0001520)4.85408558
16Cardiovascular calcification (HP:0011915)4.79588477
17Ketoacidosis (HP:0001993)4.48325562
18Late onset (HP:0003584)4.34057579
19Progressive sensorineural hearing impairment (HP:0000408)4.03483908
20Widely patent fontanelles and sutures (HP:0004492)3.90552750
21Decreased circulating renin level (HP:0003351)3.88265095
22Abnormality of renal excretion (HP:0011036)3.79617349
23Prominent supraorbital ridges (HP:0000336)3.73016399
24Urinary glycosaminoglycan excretion (HP:0003541)3.63658122
25Mucopolysacchariduria (HP:0008155)3.63658122
26Hyperparathyroidism (HP:0000843)3.62044654
27Prominent metopic ridge (HP:0005487)3.61768611
28Mitral stenosis (HP:0001718)3.52072920
29Agitation (HP:0000713)3.51778096
30Abnormal rod and cone electroretinograms (HP:0008323)3.46237682
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33659821
32Abnormality of polysaccharide metabolism (HP:0011012)3.33659821
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33659821
34Hypokalemia (HP:0002900)3.29639519
35Septate vagina (HP:0001153)3.23915486
36Urethral obstruction (HP:0000796)3.16402215
37Type II lissencephaly (HP:0007260)3.11191955
38Abnormality of the metopic suture (HP:0005556)3.10046556
39Hyperventilation (HP:0002883)3.09968606
40Increased circulating renin level (HP:0000848)3.04123417
41Hyperkalemia (HP:0002153)3.03550599
42Abnormality of renin-angiotensin system (HP:0000847)3.02759619
43Skin nodule (HP:0200036)3.02603581
44Progressive hearing impairment (HP:0001730)2.98596302
45Insulin resistance (HP:0000855)2.97870097
46Dysostosis multiplex (HP:0000943)2.97729202
47Abnormal urine output (HP:0012590)2.96416508
48Abnormal biliary tract physiology (HP:0012439)2.94097764
49Bile duct proliferation (HP:0001408)2.94097764
50Retinal atrophy (HP:0001105)2.93148963
51Abnormality of potassium homeostasis (HP:0011042)2.92649831
52Conjugated hyperbilirubinemia (HP:0002908)2.91764297
53Hydroureter (HP:0000072)2.90781671
54Osteomalacia (HP:0002749)2.87738286
55Hyperphosphatemia (HP:0002905)2.87139080
56Medial flaring of the eyebrow (HP:0010747)2.84226396
57Abnormal pancreas size (HP:0012094)2.83764054
58Unilateral renal agenesis (HP:0000122)2.82007761
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77568947
60Pancreatic cysts (HP:0001737)2.75478592
61Methylmalonic acidemia (HP:0002912)2.71518818
62Volvulus (HP:0002580)2.70152976
63Papilledema (HP:0001085)2.66719582
64Short hallux (HP:0010109)2.65120976
65Pancreatic fibrosis (HP:0100732)2.64527486
66EEG with generalized epileptiform discharges (HP:0011198)2.61871303
67Limb dystonia (HP:0002451)2.61577895
68Stomatitis (HP:0010280)2.61449562
69Arthropathy (HP:0003040)2.61076693
70Hypsarrhythmia (HP:0002521)2.61046050
71Attenuation of retinal blood vessels (HP:0007843)2.51744581
72Epileptiform EEG discharges (HP:0011182)2.50502978
73Abnormality of vitamin B metabolism (HP:0004340)2.48901002
74Aplasia/Hypoplasia of the hallux (HP:0008362)2.41392910
75Ketosis (HP:0001946)2.41070098
76Tachypnea (HP:0002789)2.41002371
77Bifid tongue (HP:0010297)2.40787510
78Cerebellar dysplasia (HP:0007033)2.40674280
79Abnormality of urine glucose concentration (HP:0011016)2.40654848
80Glycosuria (HP:0003076)2.40654848
81Abnormality of renal resorption (HP:0011038)2.35871415
82Thickened helices (HP:0000391)2.34093166
83Hyperactive renin-angiotensin system (HP:0000841)2.32730782
84Cystic liver disease (HP:0006706)2.32418247
85Hypotension (HP:0002615)2.29938417
86Abnormality of the intrinsic pathway (HP:0010989)2.26357392
87Enlarged penis (HP:0000040)2.26203503
88True hermaphroditism (HP:0010459)2.25819289
89Bony spicule pigmentary retinopathy (HP:0007737)2.24380980
90Hypercortisolism (HP:0001578)2.23062226
91Hypophosphatemia (HP:0002148)2.22575072
92Restlessness (HP:0000711)2.22323143
93Cervical subluxation (HP:0003308)2.21289496
94Hyperphosphaturia (HP:0003109)2.20737878
95Prolonged QT interval (HP:0001657)2.20490583
96Generalized hyperpigmentation (HP:0007440)2.20101469
97Congenital primary aphakia (HP:0007707)2.18714305
98Macroorchidism (HP:0000053)2.18332053
99Chronic bronchitis (HP:0004469)2.17649933
100Furrowed tongue (HP:0000221)2.16152325
101Gait imbalance (HP:0002141)2.14382464
102Methylmalonic aciduria (HP:0012120)2.14216359
103Steatorrhea (HP:0002570)2.13431417
104Menstrual irregularities (HP:0000858)2.08051123
105Nephrogenic diabetes insipidus (HP:0009806)2.07762652
106J-shaped sella turcica (HP:0002680)2.02680318
107Abnormality of homocysteine metabolism (HP:0010919)2.01342331
108Homocystinuria (HP:0002156)2.01342331
109Polydipsia (HP:0001959)2.01315185
110Abnormal drinking behavior (HP:0030082)2.01315185
111Progressive neurologic deterioration (HP:0002344)1.98960551
112Congenital glaucoma (HP:0001087)1.98853829
113Submucous cleft hard palate (HP:0000176)1.98266422
114Redundant skin (HP:0001582)1.97597544
115Adrenal overactivity (HP:0002717)1.96633124
116Barrel-shaped chest (HP:0001552)1.95369329
117Megaloblastic anemia (HP:0001889)1.95135735
118Disproportionate short-trunk short stature (HP:0003521)1.93734424
119Dysautonomia (HP:0002459)1.93264694
120Truncal obesity (HP:0001956)1.92816846
121Missing ribs (HP:0000921)1.92156396
122Hypoplastic labia majora (HP:0000059)1.91455143
123Abnormality of chloride homeostasis (HP:0011422)1.90424593
124Global brain atrophy (HP:0002283)1.89997860
125Abdominal distention (HP:0003270)1.89039200
126Tubular atrophy (HP:0000092)1.88918788
127Severe visual impairment (HP:0001141)1.87152358
128Wide cranial sutures (HP:0010537)1.84849847
129Limb hypertonia (HP:0002509)1.84427698
130Nephronophthisis (HP:0000090)1.83421561
131Abolished electroretinogram (ERG) (HP:0000550)1.83406821
132Abnormal urine phosphate concentration (HP:0012599)1.83223748
133Abnormality of vitamin metabolism (HP:0100508)1.80662294
134Abnormality of the vitamin B12 metabolism (HP:0004341)1.77833601
135Oligohydramnios (HP:0001562)1.77226496
136Occipital encephalocele (HP:0002085)1.75539225
137Cardiomegaly (HP:0001640)1.74003722
138Abnormality of magnesium homeostasis (HP:0004921)1.73277133
139Impaired smooth pursuit (HP:0007772)1.72818329
140Round ear (HP:0100830)1.72316345
141Hypothermia (HP:0002045)1.72287672
142Exocrine pancreatic insufficiency (HP:0001738)1.72209372
143Spinal muscular atrophy (HP:0007269)1.71125157
144Zonular cataract (HP:0010920)1.70959114
145Hyperaldosteronism (HP:0000859)1.70204022
146Gaze-evoked nystagmus (HP:0000640)1.69790468
147Constricted visual fields (HP:0001133)1.69770042
148Tetany (HP:0001281)1.68857823
149Abnormality of the labia majora (HP:0012881)1.68705755
150Broad-based gait (HP:0002136)1.67566399
151Absent eyebrow (HP:0002223)1.66790495
152Hyponatremia (HP:0002902)1.66542218
153Severe muscular hypotonia (HP:0006829)1.65705683
154Muscular hypotonia of the trunk (HP:0008936)1.65517294
155Abnormality of the dental root (HP:0006486)1.64511232
156Taurodontia (HP:0000679)1.64511232
157Abnormality of permanent molar morphology (HP:0011071)1.64511232
158Hemiparesis (HP:0001269)1.63042424
159Growth hormone excess (HP:0000845)1.62071970
160Congenital sensorineural hearing impairment (HP:0008527)1.61971673
161Pheochromocytoma (HP:0002666)1.61682289
162Enlarged kidneys (HP:0000105)1.61212601
163Blue irides (HP:0000635)1.60788548
164Hypomagnesemia (HP:0002917)1.60569066
165Protuberant abdomen (HP:0001538)1.59889528
166Hypocalcemia (HP:0002901)1.59084745
167Ulnar deviation of the wrist (HP:0003049)1.59045943
168Increased CSF protein (HP:0002922)1.56413870
169Orthostatic hypotension (HP:0001278)1.55339295
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55306170
171Aplasia/Hypoplasia of the fovea (HP:0008060)1.54704422
172Hypoplasia of the fovea (HP:0007750)1.54704422
173Abnormality of the common coagulation pathway (HP:0010990)1.53922936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.49154882
2INSRR4.89480287
3ACVR1B4.69198493
4IRAK44.21756342
5FRK4.07071241
6TAOK34.05046335
7MAP3K63.42562152
8PIK3CG3.30239853
9MAPK153.28285186
10PASK3.26318260
11MAP4K23.26169992
12PRKD33.23691119
13MAP3K23.16848575
14MAP3K43.02082269
15IRAK33.00195041
16UHMK12.80391064
17HIPK22.78344732
18MAP2K72.76272944
19WNK42.32116025
20STK242.20194806
21FGFR22.05348727
22MST41.94582648
23CAMKK21.90349946
24MAP3K11.89611331
25MAP2K41.81781809
26MAP3K51.75671247
27TRIB31.73295812
28PNCK1.62278358
29MAP2K61.61955907
30ERN11.52441496
31EPHA31.51960812
32PRKCH1.44811033
33IRAK11.44748380
34BMPR1B1.34483422
35PTK2B1.33151392
36PDGFRA1.31025865
37SCYL21.29262584
38NTRK11.26668083
39NTRK31.23539414
40CSNK1G11.20212215
41BMX1.19398754
42AKT31.18574757
43TAF11.18223560
44WNK11.18197183
45FLT31.16830298
46ADRBK21.16789694
47MELK1.13077590
48TRPM71.12742119
49BRSK21.12299729
50IRAK21.07397359
51GRK11.06090458
52PTK21.04007462
53PTK60.95543464
54CDC42BPA0.94497851
55DYRK1B0.92695555
56PHKG10.90694843
57PHKG20.90694843
58STK38L0.89988703
59PAK30.89252001
60MAP3K90.86100943
61PRKD20.85670870
62ZAK0.83179184
63MAPK110.82455359
64FER0.81554976
65CASK0.80620646
66RET0.76556254
67STK390.69705958
68PDPK10.69132808
69GSK3A0.66782295
70CAMKK10.66301289
71TAOK10.64222139
72PRKCQ0.63981239
73PRKAA10.60965585
74PDK10.60963731
75ALK0.60357088
76CSNK1G30.59101786
77FGR0.58876737
78MET0.58393623
79MAP3K30.56538755
80LATS10.55978606
81PRKG10.55879833
82LIMK10.55845211
83SIK10.55452199
84OXSR10.55370904
85JAK20.54523633
86VRK10.53828888
87RPS6KA20.53323701
88MAP2K20.52468491
89EPHB10.52302784
90FGFR40.51970163
91MAP3K100.51493737
92PIK3CA0.51455053
93CAMK2D0.51040844
94JAK10.50470061
95PRKCI0.49656198
96KSR20.48884795
97STK30.47597596
98RPS6KB20.45345323
99DAPK10.45214079
100MAPK130.44721814
101PRKD10.44666779
102CSNK1G20.43097666
103SGK2230.42884981
104SGK4940.42884981
105SGK30.42600705
106BCR0.41358319
107MTOR0.41280040
108EIF2AK30.41135886
109ROCK10.40308170
110EPHA20.40218589
111PRKCE0.40102966
112BMPR20.36215972
113PDGFRB0.36161606
114PRKAA20.35788326
115SGK20.35768642
116MAPKAPK30.34789110
117BRSK10.33152284
118FGFR30.32298503
119MUSK0.32127483
120IKBKB0.32075962
121CAMK2B0.30229679
122RPS6KA10.29923676
123PRKACG0.27751259
124NLK0.26066131
125CDK50.25600308
126TNK20.25272161
127ADRBK10.24540120
128CAMK1G0.24028048
129MAP2K10.23784766
130CDK120.23683187
131RPS6KA30.23504026
132MARK20.23500141
133PRKACA0.22799652
134MAPK140.20217874
135PRKDC0.19306974
136IGF1R0.18846882
137TESK10.17671570
138PRKCA0.17487527
139CSNK1A1L0.16534366
140CSNK1A10.15889032
141AKT10.15802185
142ITK0.14477464
143SGK10.13964346
144ERBB30.13499112
145GSK3B0.13426029
146BRAF0.13408050
147RPS6KB10.12640353
148PINK10.12520505
149DAPK20.11957056
150RPS6KL10.11735672
151RPS6KC10.11735672

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.95349784
2Protein export_Homo sapiens_hsa030604.66464430
3Insulin secretion_Homo sapiens_hsa049113.79669229
4Type I diabetes mellitus_Homo sapiens_hsa049402.75108739
5Type II diabetes mellitus_Homo sapiens_hsa049302.68580480
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.62184215
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.03507503
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00394701
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97593923
10Mineral absorption_Homo sapiens_hsa049781.71684191
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71639694
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64570828
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52616225
14Sulfur metabolism_Homo sapiens_hsa009201.52254038
15Vibrio cholerae infection_Homo sapiens_hsa051101.51461008
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.51428052
17Cocaine addiction_Homo sapiens_hsa050301.42217862
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40695417
19Glucagon signaling pathway_Homo sapiens_hsa049221.39385915
20Pancreatic secretion_Homo sapiens_hsa049721.38187984
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36131463
22N-Glycan biosynthesis_Homo sapiens_hsa005101.34409171
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33450205
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31154942
25Caffeine metabolism_Homo sapiens_hsa002321.28630002
26Lysosome_Homo sapiens_hsa041421.27917017
27Basal transcription factors_Homo sapiens_hsa030221.22164307
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21654427
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21523150
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18608808
31Collecting duct acid secretion_Homo sapiens_hsa049661.18248089
32Amphetamine addiction_Homo sapiens_hsa050311.17716157
33beta-Alanine metabolism_Homo sapiens_hsa004101.15463185
34Propanoate metabolism_Homo sapiens_hsa006401.15168657
35Other glycan degradation_Homo sapiens_hsa005111.13892123
36Renin-angiotensin system_Homo sapiens_hsa046141.13568059
37Cholinergic synapse_Homo sapiens_hsa047251.10986083
38Thyroid hormone synthesis_Homo sapiens_hsa049181.10278077
39Prion diseases_Homo sapiens_hsa050201.09205412
40Taste transduction_Homo sapiens_hsa047421.01972819
41ABC transporters_Homo sapiens_hsa020101.01889798
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.00439304
43Ether lipid metabolism_Homo sapiens_hsa005650.98941943
44Fatty acid degradation_Homo sapiens_hsa000710.93293792
45Estrogen signaling pathway_Homo sapiens_hsa049150.93234519
46Circadian entrainment_Homo sapiens_hsa047130.92735590
47Insulin resistance_Homo sapiens_hsa049310.90904486
48Dopaminergic synapse_Homo sapiens_hsa047280.90598329
49GABAergic synapse_Homo sapiens_hsa047270.89290479
50Cardiac muscle contraction_Homo sapiens_hsa042600.86682569
51Renin secretion_Homo sapiens_hsa049240.84386897
52Long-term potentiation_Homo sapiens_hsa047200.83861116
53Protein digestion and absorption_Homo sapiens_hsa049740.83834593
54Dorso-ventral axis formation_Homo sapiens_hsa043200.83074709
55Circadian rhythm_Homo sapiens_hsa047100.82597270
56Folate biosynthesis_Homo sapiens_hsa007900.82498858
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82379763
58Peroxisome_Homo sapiens_hsa041460.80621516
59Prolactin signaling pathway_Homo sapiens_hsa049170.80364489
60Sphingolipid metabolism_Homo sapiens_hsa006000.80033477
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78607356
62Selenocompound metabolism_Homo sapiens_hsa004500.76090858
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71893517
64Chemical carcinogenesis_Homo sapiens_hsa052040.71360127
65Serotonergic synapse_Homo sapiens_hsa047260.70842361
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69908447
67Morphine addiction_Homo sapiens_hsa050320.68129042
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68117596
69PPAR signaling pathway_Homo sapiens_hsa033200.67877574
70Synaptic vesicle cycle_Homo sapiens_hsa047210.65909327
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65179234
72Melanoma_Homo sapiens_hsa052180.65140993
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65036326
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64248373
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63947770
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63231794
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62801411
78Regulation of autophagy_Homo sapiens_hsa041400.62595708
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62570239
80Gastric acid secretion_Homo sapiens_hsa049710.62117313
81Phototransduction_Homo sapiens_hsa047440.60312664
82Gap junction_Homo sapiens_hsa045400.57472419
83Fat digestion and absorption_Homo sapiens_hsa049750.57181728
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56026709
85mTOR signaling pathway_Homo sapiens_hsa041500.55879557
86Insulin signaling pathway_Homo sapiens_hsa049100.55123658
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54265442
88cAMP signaling pathway_Homo sapiens_hsa040240.53898739
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.53782474
90Oxidative phosphorylation_Homo sapiens_hsa001900.53487367
91Vitamin digestion and absorption_Homo sapiens_hsa049770.52837816
92Melanogenesis_Homo sapiens_hsa049160.52764856
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51721967
94Long-term depression_Homo sapiens_hsa047300.50884946
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50851332
96Fatty acid metabolism_Homo sapiens_hsa012120.50722613
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48502110
98RNA degradation_Homo sapiens_hsa030180.47970052
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.45598719
100Linoleic acid metabolism_Homo sapiens_hsa005910.45042640
101Nicotine addiction_Homo sapiens_hsa050330.44477652
102Glutamatergic synapse_Homo sapiens_hsa047240.42050231
103GnRH signaling pathway_Homo sapiens_hsa049120.41997335
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39478645
105Ovarian steroidogenesis_Homo sapiens_hsa049130.39446824
106Tryptophan metabolism_Homo sapiens_hsa003800.37556146
107Butanoate metabolism_Homo sapiens_hsa006500.37296946
108Inositol phosphate metabolism_Homo sapiens_hsa005620.37135516
109Lysine degradation_Homo sapiens_hsa003100.36832629
110Bladder cancer_Homo sapiens_hsa052190.36724401
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36430850
112Oxytocin signaling pathway_Homo sapiens_hsa049210.35949884
113Thyroid cancer_Homo sapiens_hsa052160.35151656
114Alcoholism_Homo sapiens_hsa050340.35066705
115Metabolic pathways_Homo sapiens_hsa011000.34954157
116Glycerolipid metabolism_Homo sapiens_hsa005610.33437625
117Prostate cancer_Homo sapiens_hsa052150.32428650
118Nitrogen metabolism_Homo sapiens_hsa009100.31894287
119Glioma_Homo sapiens_hsa052140.30578996
120Tyrosine metabolism_Homo sapiens_hsa003500.30345537
121Renal cell carcinoma_Homo sapiens_hsa052110.30234703
122Salivary secretion_Homo sapiens_hsa049700.28965031
123Bile secretion_Homo sapiens_hsa049760.27693360
124AMPK signaling pathway_Homo sapiens_hsa041520.27384339
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26839583
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25009727
127Calcium signaling pathway_Homo sapiens_hsa040200.23459237
128Endometrial cancer_Homo sapiens_hsa052130.23288504
129Starch and sucrose metabolism_Homo sapiens_hsa005000.23258426
130Pertussis_Homo sapiens_hsa051330.22186899
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20943985
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20775780
133Dilated cardiomyopathy_Homo sapiens_hsa054140.19772573
134Olfactory transduction_Homo sapiens_hsa047400.16438683

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