PPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)6.88841505
2positive regulation by symbiont of host defense response (GO:0052509)6.42710951
3modulation by symbiont of host defense response (GO:0052031)6.42710951
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.42710951
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.42710951
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.42710951
7modulation by symbiont of host immune response (GO:0052553)6.42710951
8regulation of B cell receptor signaling pathway (GO:0050855)5.97378380
9glycosphingolipid catabolic process (GO:0046479)5.69759859
10regulation of interferon-beta biosynthetic process (GO:0045357)5.62399749
11glycolipid catabolic process (GO:0019377)5.14745766
12cellular response to exogenous dsRNA (GO:0071360)5.13215650
13antigen processing and presentation of endogenous antigen (GO:0019883)4.88654759
14ceramide catabolic process (GO:0046514)4.77491199
15oligosaccharide catabolic process (GO:0009313)4.36614228
16response to host immune response (GO:0052572)4.22098330
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22098330
18macrophage activation involved in immune response (GO:0002281)4.17039136
19positive regulation of antigen processing and presentation (GO:0002579)4.09445993
20positive regulation of chemokine biosynthetic process (GO:0045080)3.97101555
21macrophage activation (GO:0042116)3.93158712
22positive regulation of interferon-alpha production (GO:0032727)3.92844795
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.91742200
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91742200
25regulation of dendritic cell antigen processing and presentation (GO:0002604)3.87178771
26B cell mediated immunity (GO:0019724)3.86827632
27respiratory burst (GO:0045730)3.84502854
28positive regulation of gamma-delta T cell activation (GO:0046645)3.78789798
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77555281
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.77502239
31response to host (GO:0075136)3.77502239
32response to host defenses (GO:0052200)3.77502239
33positive regulation of monocyte chemotaxis (GO:0090026)3.72156350
34regulation of interferon-alpha production (GO:0032647)3.70393549
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62987986
36positive regulation of mast cell degranulation (GO:0043306)3.60677740
37positive regulation of mast cell activation involved in immune response (GO:0033008)3.60677740
38cellular response to interferon-beta (GO:0035458)3.58873157
39Rac protein signal transduction (GO:0016601)3.56685694
40positive regulation of macrophage cytokine production (GO:0060907)3.56022330
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.49070781
42positive regulation of cellular amide metabolic process (GO:0034250)3.48780107
43regulation of antigen processing and presentation (GO:0002577)3.44671772
44negative regulation of interleukin-12 production (GO:0032695)3.40524662
45amino sugar catabolic process (GO:0046348)3.33417067
46regulation of mast cell degranulation (GO:0043304)3.27762653
47regulation of lymphocyte migration (GO:2000401)3.25855064
48mast cell activation (GO:0045576)3.25814282
49phagocytosis, engulfment (GO:0006911)3.24927518
50antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16862022
51production of molecular mediator involved in inflammatory response (GO:0002532)3.12659799
52import into cell (GO:0098657)3.11149384
53glycoside metabolic process (GO:0016137)3.09520491
54* intracellular pH reduction (GO:0051452)3.09170641
55positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.06834528
56I-kappaB phosphorylation (GO:0007252)3.06460018
57regulation of hypersensitivity (GO:0002883)3.06352014
58neutrophil activation (GO:0042119)3.05804098
59granulocyte activation (GO:0036230)3.05332960
60positive regulation of B cell differentiation (GO:0045579)3.04590359
61regulation of beta-amyloid formation (GO:1902003)3.03573623
62ganglioside metabolic process (GO:0001573)3.01774257
63L-amino acid import (GO:0043092)3.01369322
64regulation of chemokine biosynthetic process (GO:0045073)2.99532147
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97825189
66regulation of mast cell activation involved in immune response (GO:0033006)2.97531258
67purine nucleobase biosynthetic process (GO:0009113)2.96966154
68myeloid cell activation involved in immune response (GO:0002275)2.96478370
69response to thyroid hormone (GO:0097066)2.96169118
70regulation of monocyte chemotaxis (GO:0090025)2.95604145
71detection of other organism (GO:0098543)2.94790145
72regulation of superoxide anion generation (GO:0032928)2.93905104
73gonadal mesoderm development (GO:0007506)2.91656597
74neutrophil mediated immunity (GO:0002446)2.90456540
75* sphingolipid catabolic process (GO:0030149)2.89920547
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89190132
77* pH reduction (GO:0045851)2.88958615
78positive regulation of T cell migration (GO:2000406)2.88525490
79response to peptidoglycan (GO:0032494)2.86122417
80positive regulation of leukocyte degranulation (GO:0043302)2.85998822
81positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.85772620
82phagosome maturation (GO:0090382)2.85412404
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85161974
84proteasome assembly (GO:0043248)2.84996413
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83952568
86positive regulation of bone remodeling (GO:0046852)2.82389635
87positive regulation of bone resorption (GO:0045780)2.82389635
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81116355
89mannose metabolic process (GO:0006013)2.80661223
90purine deoxyribonucleotide catabolic process (GO:0009155)2.80127000
91regulation of interferon-gamma biosynthetic process (GO:0045072)2.80065422
92regulation of B cell differentiation (GO:0045577)2.79497684
93negative regulation of mast cell activation (GO:0033004)2.78489962
94neutrophil activation involved in immune response (GO:0002283)2.76610654
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.76414816
96detection of bacterium (GO:0016045)2.75923285
97regulation of T cell migration (GO:2000404)2.75516900
98regulation of leukocyte degranulation (GO:0043300)2.73951429
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73820261
100signal peptide processing (GO:0006465)2.73679053
101defense response to protozoan (GO:0042832)2.71225751
102antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.70595713
103cellular response to thyroid hormone stimulus (GO:0097067)2.69723389
104purine nucleotide salvage (GO:0032261)2.69325569
105glucosamine-containing compound catabolic process (GO:1901072)2.68547835
106positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.67914232
107cellular extravasation (GO:0045123)2.67535664
108glycosylceramide metabolic process (GO:0006677)2.66407401
109negative regulation of osteoclast differentiation (GO:0045671)2.65364442
110detection of molecule of bacterial origin (GO:0032490)2.64357997
111histamine secretion (GO:0001821)2.63648148
112macrophage differentiation (GO:0030225)2.62748220
113ATP hydrolysis coupled proton transport (GO:0015991)2.62501636
114energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.62501636
115detection of external biotic stimulus (GO:0098581)2.61716228
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61021250
117negative regulation of ligase activity (GO:0051352)2.61021250
118positive regulation of interleukin-12 production (GO:0032735)2.59624965
119antigen processing and presentation via MHC class Ib (GO:0002475)2.59187227
120* membrane lipid catabolic process (GO:0046466)2.59071999
121regulation of amyloid precursor protein catabolic process (GO:1902991)2.58613216
122regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57956070
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55658354
124IMP biosynthetic process (GO:0006188)2.55631483
125myeloid leukocyte activation (GO:0002274)2.55630561
126negative regulation of B cell proliferation (GO:0030889)2.55461028
127purine-containing compound salvage (GO:0043101)2.55131390
128response to interferon-beta (GO:0035456)2.54972182
129positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54670420
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53265642
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53242830
132deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.51505157
133amyloid precursor protein catabolic process (GO:0042987)2.51292541
134G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50573559
135interferon-gamma-mediated signaling pathway (GO:0060333)2.49527528
136regulation of mast cell activation (GO:0033003)2.49178978
137regulation of gamma-delta T cell activation (GO:0046643)2.48906349
138immunoglobulin mediated immune response (GO:0016064)2.47763333
139NADPH regeneration (GO:0006740)2.47302596
140negative regulation of type 2 immune response (GO:0002829)2.46787383
141activated T cell proliferation (GO:0050798)2.45231081
142regulation of macrophage cytokine production (GO:0010935)2.44535087
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44281366
144regulation of cellular amino acid metabolic process (GO:0006521)2.43233908
145regulation of inflammatory response to antigenic stimulus (GO:0002861)2.42746051
146regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.42719949
147positive regulation of lymphocyte migration (GO:2000403)2.42081025
148oxidative phosphorylation (GO:0006119)2.41727728
149G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.41686160
150positive regulation of mast cell activation (GO:0033005)2.41542506
151nucleobase biosynthetic process (GO:0046112)2.39188804
152telomere maintenance via semi-conservative replication (GO:0032201)2.39002016
153response to protozoan (GO:0001562)2.38413270
154mast cell degranulation (GO:0043303)2.38073541
155mast cell activation involved in immune response (GO:0002279)2.38073541
156pentose-phosphate shunt (GO:0006098)2.37978447
157purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.36886221
158detection of biotic stimulus (GO:0009595)2.36601486
159leukocyte degranulation (GO:0043299)2.36257730
160myeloid dendritic cell activation (GO:0001773)2.35357156
161DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.35043246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.39114206
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.42030244
3E2F7_22180533_ChIP-Seq_HELA_Human4.33179346
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64305856
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.46847245
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.28049424
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.22576751
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.13584226
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04263057
10IKZF1_21737484_ChIP-ChIP_HCT116_Human3.03604580
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90318255
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.79556961
13* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77880989
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64640705
15GBX2_23144817_ChIP-Seq_PC3_Human2.53782031
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48098955
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.46047241
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45479510
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44534957
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40905334
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29669221
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29651209
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26524394
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25817097
25RUNX_20019798_ChIP-Seq_JUKART_Human2.23270538
26* TFEB_21752829_ChIP-Seq_HELA_Human2.20620131
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14939599
28AR_21572438_ChIP-Seq_LNCaP_Human2.08766223
29* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07462414
30* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05678639
31* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01089240
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.00471336
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99381035
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.99053678
35VDR_23849224_ChIP-Seq_CD4+_Human1.96829371
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96667047
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.94976038
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90947028
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.88707909
40FOXP3_21729870_ChIP-Seq_TREG_Human1.84473111
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83445412
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82635263
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82516885
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79904113
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79709110
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77195791
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.77088233
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75811601
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73349420
50SPI1_23127762_ChIP-Seq_K562_Human1.72863359
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67148658
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64173388
53TAF15_26573619_Chip-Seq_HEK293_Human1.63582868
54ELK1_19687146_ChIP-ChIP_HELA_Human1.63494903
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62965503
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60150950
57* DCP1A_22483619_ChIP-Seq_HELA_Human1.59213049
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58919397
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58341104
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57434562
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56910070
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52141995
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49299415
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49231990
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48815762
66EZH2_22144423_ChIP-Seq_EOC_Human1.48728374
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47778215
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44498908
69* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42509003
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41522343
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41354876
72* GABP_19822575_ChIP-Seq_HepG2_Human1.41242848
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37471005
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35341127
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33740295
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33668677
77SCL_19346495_ChIP-Seq_HPC-7_Human1.33142581
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.33114083
79DROSHA_22980978_ChIP-Seq_HELA_Human1.33059574
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31647075
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30404441
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28966889
83VDR_21846776_ChIP-Seq_THP-1_Human1.28653886
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28646714
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27515864
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27121654
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26582208
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24917752
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24487876
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24450724
91SPI1_23547873_ChIP-Seq_NB4_Human1.24254425
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22786249
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21787831
94* MYB_26560356_Chip-Seq_TH2_Human1.21712083
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18393621
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18251510
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17773777
98P300_19829295_ChIP-Seq_ESCs_Human1.17346078
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.17001816
100* MYB_26560356_Chip-Seq_TH1_Human1.16942724
101CIITA_25753668_ChIP-Seq_RAJI_Human1.15668461
102* KDM5A_27292631_Chip-Seq_BREAST_Human1.14782411
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14686839
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.10944875
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.10351100
106* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10234483
107SMAD4_21799915_ChIP-Seq_A2780_Human1.10182146
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09815832
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09759146
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09644641
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09644641
112* VDR_24787735_ChIP-Seq_THP-1_Human1.09504481
113MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09072347
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07579132
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07551186
116PU_27001747_Chip-Seq_BMDM_Mouse1.07545295
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06640259
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05914779
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04150862
120* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03497432
121* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01785461
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.01457475
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00765461
124* GATA3_26560356_Chip-Seq_TH2_Human1.00445358
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99689129
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99550467
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99550467
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99454473
129GATA1_22025678_ChIP-Seq_K562_Human0.98645927
130HTT_18923047_ChIP-ChIP_STHdh_Human0.98392364
131AR_25329375_ChIP-Seq_VCAP_Human0.98212893
132* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97572716
133* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96959092
134EGR1_19032775_ChIP-ChIP_M12_Human0.96661048
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96647152
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.95218517
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94355192
138* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94078854
139* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93311910
140* GATA3_27048872_Chip-Seq_THYMUS_Human0.93210965
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93175713
142* MAF_26560356_Chip-Seq_TH1_Human0.92724275
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92208886
144GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92115808
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91679502
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91662027
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.91458858
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91398591
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.91363802
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91323212
151* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90759546
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89283198
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.89197891
154FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88625624
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.88388863
156JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88103779
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.87893889
158P53_22387025_ChIP-Seq_ESCs_Mouse0.87373838
159VDR_24763502_ChIP-Seq_THP-1_Human0.87087076
160P300_18555785_Chip-Seq_ESCs_Mouse0.86772414
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.85324487
162PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85256644
163PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85016263
164FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82761568
165TP53_16413492_ChIP-PET_HCT116_Human0.82463218
166RNF2_27304074_Chip-Seq_ESCs_Mouse0.82356273
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81927319
168SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81833327
169PU1_27457419_Chip-Seq_LIVER_Mouse0.80647490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.55998159
2MP0004147_increased_porphyrin_level3.48659640
3MP0003806_abnormal_nucleotide_metabolis3.47333311
4MP0005058_abnormal_lysosome_morphology3.18864911
5MP0005671_abnormal_response_to2.96336819
6MP0003172_abnormal_lysosome_physiology2.72181502
7MP0002148_abnormal_hypersensitivity_rea2.66924805
8MP0003183_abnormal_peptide_metabolism2.42498465
9MP0001790_abnormal_immune_system2.33222034
10MP0005387_immune_system_phenotype2.33222034
11MP0002419_abnormal_innate_immunity2.30299630
12MP0000685_abnormal_immune_system2.29711759
13MP0002452_abnormal_antigen_presenting2.14828119
14MP0009785_altered_susceptibility_to2.10385204
15MP0005000_abnormal_immune_tolerance2.10229499
16MP0003690_abnormal_glial_cell2.00300757
17MP0000920_abnormal_myelination1.99077999
18MP0005025_abnormal_response_to1.98503857
19MP0005310_abnormal_salivary_gland1.96633292
20MP0001819_abnormal_immune_cell1.95744932
21MP0003191_abnormal_cellular_cholesterol1.89444757
22MP0001958_emphysema1.84343639
23MP0008260_abnormal_autophagy1.83894271
24MP0002420_abnormal_adaptive_immunity1.83021835
25MP0001800_abnormal_humoral_immune1.77314057
26MP0002723_abnormal_immune_serum1.72618350
27MP0002166_altered_tumor_susceptibility1.69749136
28MP0003436_decreased_susceptibility_to1.67980987
29MP0005464_abnormal_platelet_physiology1.64232109
30MP0004510_myositis1.61110840
31MP0008007_abnormal_cellular_replicative1.59054539
32MP0001853_heart_inflammation1.58254415
33MP0002876_abnormal_thyroid_physiology1.57862419
34MP0001545_abnormal_hematopoietic_system1.54544530
35MP0005397_hematopoietic_system_phenotyp1.54544530
36MP0003724_increased_susceptibility_to1.54496105
37MP0010307_abnormal_tumor_latency1.54195661
38MP0003880_abnormal_central_pattern1.53355413
39MP0003300_gastrointestinal_ulcer1.52853221
40MP0010094_abnormal_chromosome_stability1.51855490
41MP0008058_abnormal_DNA_repair1.48796485
42MP0009840_abnormal_foam_cell1.45188066
43* MP0002064_seizures1.41990172
44MP0009278_abnormal_bone_marrow1.41111229
45MP0000343_altered_response_to1.40422566
46MP0000015_abnormal_ear_pigmentation1.40414627
47MP0003075_altered_response_to1.38791644
48MP0003866_abnormal_defecation1.38121707
49MP0003111_abnormal_nucleus_morphology1.35579004
50MP0003045_fibrosis1.35134936
51MP0006036_abnormal_mitochondrial_physio1.34069238
52MP0003656_abnormal_erythrocyte_physiolo1.32881049
53MP0005409_darkened_coat_color1.28074932
54MP0002396_abnormal_hematopoietic_system1.25772499
55MP0003786_premature_aging1.25410672
56MP0000681_abnormal_thyroid_gland1.25144128
57MP0003303_peritoneal_inflammation1.21317007
58MP0002272_abnormal_nervous_system1.20830561
59MP0003195_calcinosis1.20560909
60MP0003186_abnormal_redox_activity1.20440889
61MP0001533_abnormal_skeleton_physiology1.19673446
62MP0001905_abnormal_dopamine_level1.18434226
63MP0005451_abnormal_body_composition1.16951567
64MP0002722_abnormal_immune_system1.16085979
65MP0000716_abnormal_immune_system1.15965742
66MP0000569_abnormal_digit_pigmentation1.15606974
67MP0008438_abnormal_cutaneous_collagen1.15563453
68MP0005171_absent_coat_pigmentation1.14883532
69MP0003635_abnormal_synaptic_transmissio1.13386073
70MP0002254_reproductive_system_inflammat1.13022141
71MP0009745_abnormal_behavioral_response1.12561939
72MP0002405_respiratory_system_inflammati1.09240889
73MP0002933_joint_inflammation1.07609334
74MP0001845_abnormal_inflammatory_respons1.07475661
75MP0006035_abnormal_mitochondrial_morpho1.07380985
76MP0009384_cardiac_valve_regurgitation1.06709514
77MP0010386_abnormal_urinary_bladder1.05571335
78MP0003879_abnormal_hair_cell1.05224543
79* MP0009046_muscle_twitch1.05007418
80MP0005410_abnormal_fertilization1.03440344
81MP0003633_abnormal_nervous_system1.03397915
82MP0005503_abnormal_tendon_morphology1.03395419
83* MP0002572_abnormal_emotion/affect_behav1.02785848
84MP0008995_early_reproductive_senescence1.01985371
85MP0000371_diluted_coat_color1.01530986
86MP0002006_tumorigenesis1.01284664
87MP0004947_skin_inflammation1.00791621
88MP0000858_altered_metastatic_potential1.00457778
89MP0000358_abnormal_cell_content/0.99458676
90MP0004742_abnormal_vestibular_system0.98946420
91MP0004859_abnormal_synaptic_plasticity0.98763071
92MP0005319_abnormal_enzyme/_coenzyme0.97592814
93MP0002736_abnormal_nociception_after0.97392238
94MP0003448_altered_tumor_morphology0.95460530
95MP0003329_amyloid_beta_deposits0.94348542
96MP0008057_abnormal_DNA_replication0.94217068
97MP0002398_abnormal_bone_marrow0.93043416
98MP0005408_hypopigmentation0.92647837
99MP0000604_amyloidosis0.91264758
100MP0001542_abnormal_bone_strength0.91217442
101MP0001727_abnormal_embryo_implantation0.90554927
102MP0004957_abnormal_blastocyst_morpholog0.90530551
103MP0001968_abnormal_touch/_nociception0.89409633
104* MP0002067_abnormal_sensory_capabilities0.88851565
105MP0005167_abnormal_blood-brain_barrier0.88200565
106MP0005165_increased_susceptibility_to0.87226602
107MP0009333_abnormal_splenocyte_physiolog0.86865689
108MP0005166_decreased_susceptibility_to0.86576296
109MP0006054_spinal_hemorrhage0.86445435
110MP0003693_abnormal_embryo_hatching0.86171614
111MP0003631_nervous_system_phenotype0.85935294
112MP0005647_abnormal_sex_gland0.85199440
113MP0003634_abnormal_glial_cell0.84529278
114MP0002998_abnormal_bone_remodeling0.83914054
115MP0000372_irregular_coat_pigmentation0.83515406
116MP0008569_lethality_at_weaning0.83127441
117MP0002877_abnormal_melanocyte_morpholog0.82607893
118MP0003878_abnormal_ear_physiology0.82415446
119MP0005377_hearing/vestibular/ear_phenot0.82415446
120MP0003632_abnormal_nervous_system0.82395604
121MP0009763_increased_sensitivity_to0.82300842
122MP0005595_abnormal_vascular_smooth0.82068740
123MP0001851_eye_inflammation0.81832344
124* MP0000689_abnormal_spleen_morphology0.81416096
125MP0009764_decreased_sensitivity_to0.80690096
126MP0002429_abnormal_blood_cell0.80553251
127MP0000465_gastrointestinal_hemorrhage0.80550536
128MP0001486_abnormal_startle_reflex0.79179405
129MP0000703_abnormal_thymus_morphology0.78904545
130MP0003077_abnormal_cell_cycle0.78179663
131MP0004381_abnormal_hair_follicle0.77477675
132MP0008004_abnormal_stomach_pH0.77369801
133MP0004142_abnormal_muscle_tone0.76904417
134MP0008469_abnormal_protein_level0.76716973
135MP0005646_abnormal_pituitary_gland0.74655366
136MP0002019_abnormal_tumor_incidence0.73407952
137MP0004808_abnormal_hematopoietic_stem0.72730060
138MP0002063_abnormal_learning/memory/cond0.72552087
139MP0002909_abnormal_adrenal_gland0.70427184
140MP0003828_pulmonary_edema0.70246631
141* MP0006082_CNS_inflammation0.70245280
142MP0002277_abnormal_respiratory_mucosa0.70070682
143* MP0002090_abnormal_vision0.68473733
144MP0002295_abnormal_pulmonary_circulatio0.68153189
145MP0005075_abnormal_melanosome_morpholog0.67799025
146MP0010155_abnormal_intestine_physiology0.67045590
147MP0005174_abnormal_tail_pigmentation0.66896783
148MP0001986_abnormal_taste_sensitivity0.66674767

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)6.53642860
2Abnormality of glycolipid metabolism (HP:0010969)6.53642860
3Abnormality of liposaccharide metabolism (HP:0010968)6.53642860
4Cerebral palsy (HP:0100021)4.43021016
5Recurrent abscess formation (HP:0002722)4.41024004
6Obstructive lung disease (HP:0006536)4.38581134
7Chronic obstructive pulmonary disease (HP:0006510)4.38581134
8Chronic otitis media (HP:0000389)4.32769612
9Vacuolated lymphocytes (HP:0001922)4.15624908
10Dysostosis multiplex (HP:0000943)3.86894912
11Recurrent bacterial skin infections (HP:0005406)3.61115893
12Agnosia (HP:0010524)3.53637039
13Stomatitis (HP:0010280)3.32482844
14Eczematoid dermatitis (HP:0000976)3.31410637
15Disinhibition (HP:0000734)3.25311436
16Meningitis (HP:0001287)3.23463485
17Acrocyanosis (HP:0001063)3.03614479
18Poor head control (HP:0002421)3.02176359
19Testicular atrophy (HP:0000029)2.98592556
20Urinary glycosaminoglycan excretion (HP:0003541)2.97036265
21Mucopolysacchariduria (HP:0008155)2.97036265
22Emphysema (HP:0002097)2.96475939
23* Increased cerebral lipofuscin (HP:0011813)2.94194055
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.91892565
25J-shaped sella turcica (HP:0002680)2.86000659
26Nephritis (HP:0000123)2.82363588
27Abnormality of complement system (HP:0005339)2.77822099
28Elevated erythrocyte sedimentation rate (HP:0003565)2.76936677
29Chronic sinusitis (HP:0011109)2.75753693
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74931699
31Abnormality of polysaccharide metabolism (HP:0011012)2.74931699
32Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74931699
33Hemoptysis (HP:0002105)2.69976850
34Diminished motivation (HP:0000745)2.69403854
35* Increased neuronal autofluorescent lipopigment (HP:0002074)2.68901273
36Mutism (HP:0002300)2.68704179
37IgM deficiency (HP:0002850)2.68239557
38Azoospermia (HP:0000027)2.64642904
39Abnormality of the pleura (HP:0002103)2.63352318
40Recurrent cutaneous fungal infections (HP:0011370)2.62728206
41Chronic mucocutaneous candidiasis (HP:0002728)2.62728206
42Abnormality of macrophages (HP:0004311)2.60804126
43Myositis (HP:0100614)2.60332750
44Vasculitis (HP:0002633)2.59931807
45Gonadal dysgenesis (HP:0000133)2.58520492
46Apathy (HP:0000741)2.54519565
47Petechiae (HP:0000967)2.49843854
48Pulmonary fibrosis (HP:0002206)2.47366223
49Cellulitis (HP:0100658)2.43853427
50Recurrent skin infections (HP:0001581)2.43066296
51Skin rash (HP:0000988)2.42137039
52Recurrent viral infections (HP:0004429)2.40622660
53Agammaglobulinemia (HP:0004432)2.39780290
54Abnormality of binocular vision (HP:0011514)2.37713555
55Diplopia (HP:0000651)2.37713555
56Cardiomegaly (HP:0001640)2.35203446
57Colitis (HP:0002583)2.34811301
58Arthropathy (HP:0003040)2.34515493
59Amaurosis fugax (HP:0100576)2.33702319
60Basal ganglia calcification (HP:0002135)2.29692222
61Orchitis (HP:0100796)2.28692822
62Progressive neurologic deterioration (HP:0002344)2.27718236
63Clumsiness (HP:0002312)2.26249381
64Abnormality of the prostate (HP:0008775)2.25279764
65Gonadotropin excess (HP:0000837)2.24714657
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24433432
67Restrictive lung disease (HP:0002091)2.23724643
68Recurrent gram-negative bacterial infections (HP:0005420)2.23440984
69Degeneration of anterior horn cells (HP:0002398)2.22873701
70Abnormality of the anterior horn cell (HP:0006802)2.22873701
71Abnormality of the pericardium (HP:0001697)2.20941184
72Interstitial pulmonary disease (HP:0006530)2.20612448
73Type I transferrin isoform profile (HP:0003642)2.20206000
74Recurrent bronchitis (HP:0002837)2.17107943
75Mediastinal lymphadenopathy (HP:0100721)2.17080699
76Nasal polyposis (HP:0100582)2.15712511
77Pulmonary infiltrates (HP:0002113)2.15245687
78Mitral stenosis (HP:0001718)2.11123319
79Microvesicular hepatic steatosis (HP:0001414)2.10963955
80Multiple enchondromatosis (HP:0005701)2.10437010
81Axonal loss (HP:0003447)2.08937165
82Deformed sella turcica (HP:0002681)2.07846341
83* Loss of speech (HP:0002371)2.05863731
84Abnormality of the nasal mucosa (HP:0000433)2.04581004
85Abnormality of the basal ganglia (HP:0002134)2.03218707
86Hypokinesia (HP:0002375)2.02907688
87Urticaria (HP:0001025)2.02473705
88Focal motor seizures (HP:0011153)2.01870915
89Recurrent fungal infections (HP:0002841)1.99324222
90Purpura (HP:0000979)1.96578593
91Systemic lupus erythematosus (HP:0002725)1.96134902
92Inflammation of the large intestine (HP:0002037)1.96000311
93Gastrointestinal stroma tumor (HP:0100723)1.94943453
94Recurrent pneumonia (HP:0006532)1.93168717
95Osteomyelitis (HP:0002754)1.91284277
96Increased serum ferritin (HP:0003281)1.90120720
97Personality changes (HP:0000751)1.90046860
98Vertebral compression fractures (HP:0002953)1.89899918
99Encephalitis (HP:0002383)1.87089121
100Abnormality of B cell number (HP:0010975)1.86606901
101B lymphocytopenia (HP:0010976)1.86606901
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86573590
103Abnormal protein N-linked glycosylation (HP:0012347)1.86573590
104Abnormal protein glycosylation (HP:0012346)1.86573590
105Abnormal glycosylation (HP:0012345)1.86573590
106Hepatosplenomegaly (HP:0001433)1.86492794
107Symptomatic seizures (HP:0011145)1.86490824
108Hypergammaglobulinemia (HP:0010702)1.86365897
109Upper motor neuron abnormality (HP:0002127)1.86307327
110Glomerulopathy (HP:0100820)1.86094527
111Abnormality of male internal genitalia (HP:0000022)1.85397630
112Supranuclear gaze palsy (HP:0000605)1.84739059
113Dementia (HP:0000726)1.84136929
114Neurofibrillary tangles (HP:0002185)1.83831585
115T lymphocytopenia (HP:0005403)1.82976182
116Combined immunodeficiency (HP:0005387)1.81772360
117Paralysis (HP:0003470)1.81448090
118Spastic paraparesis (HP:0002313)1.81043473
119Mucosal telangiectasiae (HP:0100579)1.80525393
120Polyneuropathy (HP:0001271)1.79346614
121Thrombocytosis (HP:0001894)1.79237097
122Acute necrotizing encephalopathy (HP:0006965)1.79095780
123Abnormal mitochondria in muscle tissue (HP:0008316)1.78252549
124Cortical visual impairment (HP:0100704)1.77897390
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76746325
126Prolonged neonatal jaundice (HP:0006579)1.76731493
127Stridor (HP:0010307)1.76667373
128Recurrent sinusitis (HP:0011108)1.75466405
129Nausea (HP:0002018)1.74824516
130Gastrointestinal inflammation (HP:0004386)1.74369161
131Prostate neoplasm (HP:0100787)1.74302877
132Hypomagnesemia (HP:0002917)1.73922695
133IgG deficiency (HP:0004315)1.73824616
134Hepatocellular necrosis (HP:0001404)1.73533708
135Abnormality of lateral ventricle (HP:0030047)1.73027962
136Paresthesia (HP:0003401)1.73002505
137Panhypogammaglobulinemia (HP:0003139)1.72370319
138Abnormality of iron homeostasis (HP:0011031)1.71074821
139Abnormal spermatogenesis (HP:0008669)1.70853261
140Amyloidosis (HP:0011034)1.70699403
141Autoimmune thrombocytopenia (HP:0001973)1.70548209
142Acute encephalopathy (HP:0006846)1.70083177
143Hypoplasia of the odontoid process (HP:0003311)1.69984222
144Myocardial infarction (HP:0001658)1.69886363
145Increased CSF lactate (HP:0002490)1.68890971
146Abnormality of methionine metabolism (HP:0010901)1.68777199
147Optic neuritis (HP:0100653)1.68569775
148Retrobulbar optic neuritis (HP:0100654)1.68569775
149Anorexia (HP:0002039)1.68151717
150Gingivitis (HP:0000230)1.67906299
151Respiratory failure (HP:0002878)1.67425402
152Glomerulonephritis (HP:0000099)1.67091931
153Increased CSF protein (HP:0002922)1.67066138
154Albinism (HP:0001022)1.65795655
155Neuronal loss in central nervous system (HP:0002529)1.64631889
156Mitochondrial inheritance (HP:0001427)1.64475004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.01098264
2MAP4K13.97744861
3EIF2AK33.12191234
4CDK193.02856377
5EIF2AK12.99402877
6CSF1R2.91447120
7NME22.87820527
8BLK2.75225799
9KIT2.71924666
10MYLK2.53061976
11BUB12.43165149
12EPHB12.36616942
13TNIK2.29345699
14OXSR12.19341878
15FES2.16148695
16TXK2.15217291
17SYK2.07540342
18IRAK41.99204915
19TBK11.87349343
20PBK1.77965407
21RIPK41.75541194
22STK161.75102205
23TRIM281.71834898
24MAP3K141.71331609
25CASK1.70276911
26GRK11.64501744
27TYK21.63791610
28TESK21.61078726
29BCKDK1.60827411
30ITK1.59922214
31TSSK61.59318250
32TEC1.58251336
33PDK21.44388113
34TAOK31.41257940
35VRK21.38529572
36CSK1.33020599
37NEK11.32335307
38LYN1.30054512
39MAP4K21.28601753
40BMPR1B1.25964883
41JAK11.24430088
42SRPK11.24422447
43TGFBR21.24241179
44NUAK11.24147669
45MST41.23493280
46TTK1.16367165
47FGR1.14638539
48MUSK1.13940311
49STK241.12214221
50BTK1.11267929
51STK391.10978839
52ZAP701.07001924
53MAP2K31.06938140
54HCK1.03278188
55ALK1.00386218
56MAP2K70.99583479
57ERN10.97968997
58ADRBK20.96858440
59PDK10.96756774
60STK100.95506899
61PLK20.94268121
62TNK20.93857360
63PLK30.93837039
64GRK70.93241999
65MAPKAPK50.93122949
66PRKCQ0.92445031
67CDK60.91738846
68IKBKE0.91095204
69SIK30.89515061
70BMPR20.87649150
71PIM20.85807254
72IKBKB0.84556654
73LCK0.83274910
74WNK10.82550735
75WNK30.82004346
76DAPK20.81988745
77MATK0.81556742
78MAP3K30.81435155
79DAPK10.80025994
80PTK2B0.78306442
81MKNK10.78203133
82EIF2AK20.75814560
83FER0.75114116
84CLK10.74278274
85MAPK130.72990163
86NEK90.72059607
87CSNK1G30.71398928
88PRKCH0.70270512
89FLT30.66872117
90MAP2K60.66776223
91CDC70.66526237
92MAPK150.65407161
93NTRK30.65098047
94PAK40.64926022
95WNK40.64186758
96GRK60.63510985
97TESK10.63271180
98MAP3K80.61668554
99CAMKK10.59628610
100CCNB10.58575138
101FYN0.56965481
102NEK60.55853649
103ABL20.55570981
104LRRK20.55032588
105CDK50.54294549
106ATR0.52866341
107PDPK10.51869379
108KDR0.51678856
109PRKCD0.51145069
110MAP3K50.50970883
111CSNK1G10.50412377
112MARK30.49745971
113YES10.49099988
114SGK4940.49075255
115SGK2230.49075255
116PKN10.48576128
117ZAK0.48534987
118PRKCE0.48401915
119MINK10.48082626
120NLK0.47832576
121ROCK20.47815071
122CSNK1G20.46988272
123MAPKAPK20.46406804
124RPS6KA40.46003726
125JAK30.45217223
126MAP3K10.42733837
127TRPM70.41973183
128SGK30.41659849
129PLK40.41622497
130IRAK20.41161652
131CSNK2A10.41013806
132PLK10.41010894
133MAPKAPK30.40264291
134PIK3CG0.40014080
135IRAK30.38978989
136UHMK10.38753050
137SGK20.38667768
138EGFR0.38611843
139CAMKK20.37674480
140TYRO30.37427560
141LIMK10.37314853
142ACVR1B0.37083961
143MAP3K130.37022763
144PRPF4B0.36330907
145SCYL20.36105853
146JAK20.35376836
147GRK50.35052398
148IGF1R0.34318373
149ERBB30.33963777
150NTRK20.33670577
151ABL10.31821006

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.21972256
2Proteasome_Homo sapiens_hsa030503.18509918
3* Lysosome_Homo sapiens_hsa041422.84285970
4Asthma_Homo sapiens_hsa053102.83251692
5Other glycan degradation_Homo sapiens_hsa005112.55573781
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.44870448
7DNA replication_Homo sapiens_hsa030302.36599181
8Graft-versus-host disease_Homo sapiens_hsa053322.18116828
9Protein export_Homo sapiens_hsa030602.09289546
10Mismatch repair_Homo sapiens_hsa034302.04041769
11Phagosome_Homo sapiens_hsa041451.97915724
12Vibrio cholerae infection_Homo sapiens_hsa051101.80291720
13Collecting duct acid secretion_Homo sapiens_hsa049661.77819535
14Primary immunodeficiency_Homo sapiens_hsa053401.76950987
15Rheumatoid arthritis_Homo sapiens_hsa053231.68698531
16Non-homologous end-joining_Homo sapiens_hsa034501.62898765
17Leishmaniasis_Homo sapiens_hsa051401.61636213
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.60159482
19Antigen processing and presentation_Homo sapiens_hsa046121.54982287
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54398681
21B cell receptor signaling pathway_Homo sapiens_hsa046621.52793223
22Malaria_Homo sapiens_hsa051441.52604555
23Salmonella infection_Homo sapiens_hsa051321.47535648
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47259402
25Synaptic vesicle cycle_Homo sapiens_hsa047211.46085679
26Osteoclast differentiation_Homo sapiens_hsa043801.43377135
27Base excision repair_Homo sapiens_hsa034101.42227254
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41293246
29Chemokine signaling pathway_Homo sapiens_hsa040621.37830501
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37638683
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36145976
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34442969
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33405242
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.33258985
35Tuberculosis_Homo sapiens_hsa051521.30967413
36Morphine addiction_Homo sapiens_hsa050321.27870987
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27813785
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26998306
39Staphylococcus aureus infection_Homo sapiens_hsa051501.26926474
40Pertussis_Homo sapiens_hsa051331.26240598
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26016793
42Homologous recombination_Homo sapiens_hsa034401.23757509
43Shigellosis_Homo sapiens_hsa051311.23430117
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21790131
45* Fatty acid elongation_Homo sapiens_hsa000621.20278667
46Nicotine addiction_Homo sapiens_hsa050331.18585370
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18261683
48Salivary secretion_Homo sapiens_hsa049701.13625731
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12730227
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11999150
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11967995
52Renin secretion_Homo sapiens_hsa049241.11510819
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11136472
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10364657
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10131336
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09258716
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07393820
58Gastric acid secretion_Homo sapiens_hsa049711.06356942
59GABAergic synapse_Homo sapiens_hsa047271.05656083
60Pentose phosphate pathway_Homo sapiens_hsa000301.04878230
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04529308
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04255247
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.04085209
64Sphingolipid metabolism_Homo sapiens_hsa006001.03793224
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98664691
66Toxoplasmosis_Homo sapiens_hsa051450.97804542
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96428630
68Olfactory transduction_Homo sapiens_hsa047400.95363106
69Glutathione metabolism_Homo sapiens_hsa004800.93960600
70Platelet activation_Homo sapiens_hsa046110.93388166
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93282154
72Spliceosome_Homo sapiens_hsa030400.91722858
73Circadian entrainment_Homo sapiens_hsa047130.88257542
74Influenza A_Homo sapiens_hsa051640.86488892
75Carbon metabolism_Homo sapiens_hsa012000.86028208
76Glutamatergic synapse_Homo sapiens_hsa047240.84499533
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.82867931
78Vitamin B6 metabolism_Homo sapiens_hsa007500.81945616
79Sulfur metabolism_Homo sapiens_hsa009200.81533560
80Serotonergic synapse_Homo sapiens_hsa047260.81147495
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80962525
82Parkinsons disease_Homo sapiens_hsa050120.80778158
83Hematopoietic cell lineage_Homo sapiens_hsa046400.80009345
84cAMP signaling pathway_Homo sapiens_hsa040240.79407442
85Epstein-Barr virus infection_Homo sapiens_hsa051690.78379831
86Calcium signaling pathway_Homo sapiens_hsa040200.77910808
87Pyrimidine metabolism_Homo sapiens_hsa002400.77838064
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77017305
89Ether lipid metabolism_Homo sapiens_hsa005650.76493557
90African trypanosomiasis_Homo sapiens_hsa051430.75747459
91Viral myocarditis_Homo sapiens_hsa054160.75466556
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75074564
93Galactose metabolism_Homo sapiens_hsa000520.74745141
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74494634
95Measles_Homo sapiens_hsa051620.74273406
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73521549
97Endocytosis_Homo sapiens_hsa041440.73189990
98One carbon pool by folate_Homo sapiens_hsa006700.72978066
99Nucleotide excision repair_Homo sapiens_hsa034200.71901185
100Vitamin digestion and absorption_Homo sapiens_hsa049770.70817623
101Mineral absorption_Homo sapiens_hsa049780.70152721
102T cell receptor signaling pathway_Homo sapiens_hsa046600.69816746
103Legionellosis_Homo sapiens_hsa051340.69662450
104Allograft rejection_Homo sapiens_hsa053300.69193874
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65618581
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65036294
107Dopaminergic synapse_Homo sapiens_hsa047280.64792760
108N-Glycan biosynthesis_Homo sapiens_hsa005100.63066313
109Fanconi anemia pathway_Homo sapiens_hsa034600.62818025
110Long-term depression_Homo sapiens_hsa047300.62336708
111Long-term potentiation_Homo sapiens_hsa047200.61410930
112Oxidative phosphorylation_Homo sapiens_hsa001900.60961338
113RNA transport_Homo sapiens_hsa030130.60447755
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59378451
115Regulation of autophagy_Homo sapiens_hsa041400.57559800
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57411797
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56479374
118Folate biosynthesis_Homo sapiens_hsa007900.56127136
119Pancreatic secretion_Homo sapiens_hsa049720.56054126
120Amphetamine addiction_Homo sapiens_hsa050310.55723571
121Renin-angiotensin system_Homo sapiens_hsa046140.55567390
122Cholinergic synapse_Homo sapiens_hsa047250.54607346
123RNA polymerase_Homo sapiens_hsa030200.54098297
124Propanoate metabolism_Homo sapiens_hsa006400.53624171
125Amoebiasis_Homo sapiens_hsa051460.53315128
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52958057
127Herpes simplex infection_Homo sapiens_hsa051680.51640980
128RNA degradation_Homo sapiens_hsa030180.51310558
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.51051932
130Steroid biosynthesis_Homo sapiens_hsa001000.50501789
131Autoimmune thyroid disease_Homo sapiens_hsa053200.50165961
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50152080
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49079885
134Axon guidance_Homo sapiens_hsa043600.48996983
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48745877
136Oxytocin signaling pathway_Homo sapiens_hsa049210.48468501
137Taste transduction_Homo sapiens_hsa047420.48315599
138Type I diabetes mellitus_Homo sapiens_hsa049400.48157952
139Peroxisome_Homo sapiens_hsa041460.47846283
140Alzheimers disease_Homo sapiens_hsa050100.46978215
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44899451
142Purine metabolism_Homo sapiens_hsa002300.44861036
1432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39350391
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37980284
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37968440
146Pyruvate metabolism_Homo sapiens_hsa006200.35452055
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33461497
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.30111984
149Hepatitis B_Homo sapiens_hsa051610.28354694
150Fructose and mannose metabolism_Homo sapiens_hsa000510.27036655

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