PPP6R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase regulatory subunits, such as SAPS2, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS2 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.72050772
2synaptic vesicle maturation (GO:0016188)4.64722112
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48980374
4mannose metabolic process (GO:0006013)4.12151453
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10222506
6sodium ion export (GO:0071436)4.08582672
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.07696071
8negative regulation of erythrocyte differentiation (GO:0045647)4.07671850
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.01164487
10layer formation in cerebral cortex (GO:0021819)3.90492877
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83364670
12cell communication by electrical coupling (GO:0010644)3.82598413
13negative regulation of fibrinolysis (GO:0051918)3.78725520
14vocalization behavior (GO:0071625)3.75542231
15cellular potassium ion homeostasis (GO:0030007)3.71971993
16regulation of synapse structural plasticity (GO:0051823)3.67470618
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.61846015
18glutamate secretion (GO:0014047)3.58416540
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49483214
20activation of protein kinase A activity (GO:0034199)3.49211737
21synaptic vesicle exocytosis (GO:0016079)3.48153048
22regulation of synaptic vesicle exocytosis (GO:2000300)3.38342066
23regulation of glutamate receptor signaling pathway (GO:1900449)3.36459739
24regulation of ARF protein signal transduction (GO:0032012)3.36302817
25gamma-aminobutyric acid transport (GO:0015812)3.33215691
26positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.31796079
27cell communication involved in cardiac conduction (GO:0086065)3.31639201
28neurotransmitter secretion (GO:0007269)3.30093079
29potassium ion import (GO:0010107)3.29930167
30negative regulation of cell killing (GO:0031342)3.27178073
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27178073
32exploration behavior (GO:0035640)3.26274366
33protein carboxylation (GO:0018214)3.25725677
34peptidyl-glutamic acid carboxylation (GO:0017187)3.25725677
35cerebellar Purkinje cell differentiation (GO:0021702)3.23869077
36regulation of fibrinolysis (GO:0051917)3.17919143
37complement activation, alternative pathway (GO:0006957)3.16938607
38establishment of nucleus localization (GO:0040023)3.12295321
39plasma membrane repair (GO:0001778)3.09697189
40membrane depolarization during action potential (GO:0086010)3.08892873
41neuronal action potential propagation (GO:0019227)3.08852592
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08473314
43regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.06498978
44neurotransmitter-gated ion channel clustering (GO:0072578)3.06358791
45regulation of neuronal synaptic plasticity (GO:0048168)3.05635442
46regulation of synaptic vesicle transport (GO:1902803)3.03961437
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.01720174
48dendrite morphogenesis (GO:0048813)3.00490782
49regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98734535
50protein-lipid complex assembly (GO:0065005)2.98357113
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.97905983
52regulation of apoptotic cell clearance (GO:2000425)2.96519217
53neuromuscular process controlling balance (GO:0050885)2.94750224
54positive regulation of synapse maturation (GO:0090129)2.94667985
55cytoskeletal anchoring at plasma membrane (GO:0007016)2.94475531
56regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.92209892
57response to pheromone (GO:0019236)2.92199764
58dendritic spine morphogenesis (GO:0060997)2.92169533
59positive regulation of gamma-delta T cell activation (GO:0046645)2.91049643
60regulation of ARF GTPase activity (GO:0032312)2.90096381
61protein localization to synapse (GO:0035418)2.89469105
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89405711
63dicarboxylic acid biosynthetic process (GO:0043650)2.87874494
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87552932
65proline transport (GO:0015824)2.87237658
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87089708
67regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83959036
68plasma lipoprotein particle assembly (GO:0034377)2.83586760
69regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83546135
70cellular sodium ion homeostasis (GO:0006883)2.83351479
71negative regulation of cell size (GO:0045792)2.82482399
72regulation of cholesterol homeostasis (GO:2000188)2.80404143
73positive regulation of triglyceride lipase activity (GO:0061365)2.79426543
74positive regulation of lipoprotein lipase activity (GO:0051006)2.79426543
75protein localization to endosome (GO:0036010)2.78913945
76negative regulation of potassium ion transmembrane transport (GO:1901380)2.78269288
77regulation of membrane repolarization (GO:0060306)2.77834975
78regulation of extracellular matrix disassembly (GO:0010715)2.77582620
79regulation of protein activation cascade (GO:2000257)2.77147505
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76896526
81phospholipid efflux (GO:0033700)2.76566090
82long-term memory (GO:0007616)2.76490001
83negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74070342
84antigen processing and presentation of endogenous antigen (GO:0019883)2.73960541
85cerebellar granule cell differentiation (GO:0021707)2.73258240
86positive regulation of potassium ion transmembrane transport (GO:1901381)2.72830802
87synaptic transmission, glutamatergic (GO:0035249)2.70557353
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70344575
89positive regulation of extracellular matrix organization (GO:1903055)2.68920368
90alanine transport (GO:0032328)2.68186629
91regulation of complement activation (GO:0030449)2.67788530
92glycine transport (GO:0015816)2.66732757
93positive thymic T cell selection (GO:0045059)2.66462614
94regulation of calcium ion transmembrane transporter activity (GO:1901019)2.63989928
95regulation of calcium ion transmembrane transport (GO:1903169)2.63989928
96positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.63067582
97response to muramyl dipeptide (GO:0032495)2.63057219
98regulation of dendritic spine morphogenesis (GO:0061001)2.62779638
99glutamate receptor signaling pathway (GO:0007215)2.62747847
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62294521
101cerebellar Purkinje cell layer development (GO:0021680)2.59247961
102prepulse inhibition (GO:0060134)2.58233982
103regulation of cholesterol esterification (GO:0010872)2.57329249
104neuromuscular process controlling posture (GO:0050884)2.56203187
105cardiac muscle contraction (GO:0060048)2.55619249
106potassium ion homeostasis (GO:0055075)2.54314633
107barbed-end actin filament capping (GO:0051016)2.53212860
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52896851
109membrane repolarization (GO:0086009)2.52546671
110response to laminar fluid shear stress (GO:0034616)2.51538553
111detection of bacterium (GO:0016045)2.50820989
112negative regulation of fatty acid transport (GO:2000192)2.49943215
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.49782191
114urea metabolic process (GO:0019627)2.49659128
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49419305
116positive regulation of Rap GTPase activity (GO:0032854)2.48816603
117regulation of postsynaptic membrane potential (GO:0060078)2.48725991
118carnitine shuttle (GO:0006853)2.48449971
119regulation of extracellular matrix organization (GO:1903053)2.47420576
120detection of other organism (GO:0098543)2.47420226
121very-low-density lipoprotein particle assembly (GO:0034379)2.47008501
122cholesterol efflux (GO:0033344)2.46008614
123urea cycle (GO:0000050)2.45834899
124neurotransmitter transport (GO:0006836)2.45135650
125neuron-neuron synaptic transmission (GO:0007270)2.44580603
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44214301
127modulation by symbiont of host defense response (GO:0052031)2.44140758
128modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44140758
129modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44140758
130positive regulation by organism of defense response of other organism involved in symbiotic interact2.44140758
131modulation by symbiont of host immune response (GO:0052553)2.44140758
132positive regulation by symbiont of host defense response (GO:0052509)2.44140758
133negative regulation of sterol transport (GO:0032372)2.44090888
134negative regulation of cholesterol transport (GO:0032375)2.44090888
135regulation of cholesterol biosynthetic process (GO:0045540)2.43735442
136signal complex assembly (GO:0007172)2.43111285
137thymic T cell selection (GO:0045061)2.42794966
138cardiac myofibril assembly (GO:0055003)2.42608435
139nitrogen cycle metabolic process (GO:0071941)2.42540415
140synaptic vesicle endocytosis (GO:0048488)2.42372002
141regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42012643
142positive regulation of membrane potential (GO:0045838)2.41482682
143regulation of cholesterol metabolic process (GO:0090181)2.41398065
144membrane depolarization (GO:0051899)2.41221160
145cell migration in hindbrain (GO:0021535)2.40750818
146positive regulation of sodium ion transport (GO:0010765)2.40406722
147positive regulation of phagocytosis (GO:0050766)2.39577878
148acute-phase response (GO:0006953)2.39514860
149regulation of monocyte differentiation (GO:0045655)2.39350988
150regulation of T-helper 2 cell differentiation (GO:0045628)2.39314526
151membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.39192741
152vesicle transport along microtubule (GO:0047496)2.39086597
153protein targeting to Golgi (GO:0000042)2.38381178
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.38320169
155nerve growth factor signaling pathway (GO:0038180)2.38261798
156macrophage activation involved in immune response (GO:0002281)2.38103760
157protein-lipid complex subunit organization (GO:0071825)2.38022447
158regulation of neurotransmitter levels (GO:0001505)2.37108482
159regulation of ion transmembrane transporter activity (GO:0032412)2.35698850
160cell differentiation in hindbrain (GO:0021533)2.35073723
161positive regulation of potassium ion transport (GO:0043268)2.34653834
162regulation of synaptic plasticity (GO:0048167)2.34553542
163positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.34268821
164cell-cell junction maintenance (GO:0045217)2.32316848
165activation of JUN kinase activity (GO:0007257)2.31556088
166detection of external biotic stimulus (GO:0098581)2.30237649
167regulation of early endosome to late endosome transport (GO:2000641)2.30024238
168regulation of gamma-delta T cell activation (GO:0046643)2.30000863
169plasma lipoprotein particle remodeling (GO:0034369)2.29378849
170protein-lipid complex remodeling (GO:0034368)2.29378849
171macromolecular complex remodeling (GO:0034367)2.29378849
172regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28526575
173pinocytosis (GO:0006907)2.27254081
174cell-substrate adherens junction assembly (GO:0007045)2.27249297
175focal adhesion assembly (GO:0048041)2.27249297
176regulation of fatty acid biosynthetic process (GO:0042304)2.26640524
177plasma lipoprotein particle organization (GO:0071827)2.26506480
178adherens junction assembly (GO:0034333)2.26370270
179negative regulation of myotube differentiation (GO:0010832)2.26186986
180germinal center formation (GO:0002467)2.25706751
181modulation by symbiont of host cellular process (GO:0044068)2.25160659
182negative regulation of lipid transport (GO:0032369)2.24905099
183antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.24270719
184NIK/NF-kappaB signaling (GO:0038061)2.24154949
185plasma lipoprotein particle clearance (GO:0034381)2.22469870
186regulation of gamma-delta T cell differentiation (GO:0045586)2.22333271
187low-density lipoprotein particle remodeling (GO:0034374)2.21738518
188positive regulation of fatty acid biosynthetic process (GO:0045723)2.20782529
189regulation of leukocyte degranulation (GO:0043300)2.20462952
190activation of MAPKKK activity (GO:0000185)2.18809774
191creatine metabolic process (GO:0006600)2.17611967
192negative regulation of toll-like receptor signaling pathway (GO:0034122)2.16968839
193negative regulation of granulocyte differentiation (GO:0030853)2.15709784
194diacylglycerol metabolic process (GO:0046339)2.15236463
195regulation of phagocytosis (GO:0050764)2.15165136
196detection of molecule of bacterial origin (GO:0032490)2.14982199
197regulation of NFAT protein import into nucleus (GO:0051532)2.14608503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.21417948
2VDR_21846776_ChIP-Seq_THP-1_Human2.86439594
3* DROSHA_22980978_ChIP-Seq_HELA_Human2.63772343
4MYC_22102868_ChIP-Seq_BL_Human2.52633101
5KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.43399168
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.35414914
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33617414
8TCF7_22412390_ChIP-Seq_EML_Mouse2.31593898
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30592529
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25722305
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.25630427
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17110571
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16155275
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10608635
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09675292
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08992518
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08992518
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05432522
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01997139
20REST_21632747_ChIP-Seq_MESCs_Mouse2.01173000
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98102916
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.95834455
23RACK7_27058665_Chip-Seq_MCF-7_Human1.87432158
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86509032
25GBX2_23144817_ChIP-Seq_PC3_Human1.84221636
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.81085485
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77908466
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.77666168
29VDR_24763502_ChIP-Seq_THP-1_Human1.76322618
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75336097
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72840172
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71601910
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71050751
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69388323
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68821436
36P68_20966046_ChIP-Seq_HELA_Human1.67196457
37KDM2B_26808549_Chip-Seq_K562_Human1.65879333
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.65709071
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.63768641
40MAF_26560356_Chip-Seq_TH1_Human1.61750661
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52838673
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.52525394
43CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52174200
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49927894
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49772399
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.49253545
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49148855
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48271016
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48115414
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48051204
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.46775741
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.46571838
53UTX_26944678_Chip-Seq_JUKART_Human1.46082044
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44872359
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42233802
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.41898748
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.41851044
58MAF_26560356_Chip-Seq_TH2_Human1.39893833
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39399420
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39215750
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39100461
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.38502594
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38271892
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38252140
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.36810017
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36656058
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36205711
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35797715
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35708267
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34862929
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33325232
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33071983
73ZNF274_21170338_ChIP-Seq_K562_Hela1.31341086
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30253479
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28825724
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.28655985
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28588188
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.26913369
79BCOR_27268052_Chip-Seq_Bcells_Human1.26456574
80SPI1_23127762_ChIP-Seq_K562_Human1.25973744
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25274883
82KDM2B_26808549_Chip-Seq_DND41_Human1.24107633
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.23788548
84AR_19668381_ChIP-Seq_PC3_Human1.23413933
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.22537225
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22418280
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.22344102
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21194364
89AR_21572438_ChIP-Seq_LNCaP_Human1.20489641
90ZNF263_19887448_ChIP-Seq_K562_Human1.20432260
91BCL6_27268052_Chip-Seq_Bcells_Human1.20255397
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.19824067
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18961922
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18594517
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18549650
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18397198
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17264336
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.17106331
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16874244
100LXR_22292898_ChIP-Seq_THP-1_Human1.16567052
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16344570
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15961958
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15856516
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15662161
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14860273
106CLOCK_20551151_ChIP-Seq_293T_Human1.13758927
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12712683
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.12700638
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12685098
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11623951
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11622093
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10838259
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10831958
114NCOR1_26117541_ChIP-Seq_K562_Human1.10281534
115SMAD4_21799915_ChIP-Seq_A2780_Human1.08942223
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08925952
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08074028
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.07954192
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07678175
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.07203197
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06956830
122AHR_22903824_ChIP-Seq_MCF-7_Human1.06842536
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06289210
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.06058051
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05361456
126CTCF_27219007_Chip-Seq_Bcells_Human1.05045336
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03577697
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03470275
129PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02814860
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02417588
131PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02150679
132TBX20_22328084_ChIP-Seq_HEART_Mouse1.01853545
133TBX20_22080862_ChIP-Seq_HEART_Mouse1.01853545
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.01744765
135SCL_19346495_ChIP-Seq_HPC-7_Human1.01628877
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01332175
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01252486
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00363392
139TP63_22573176_ChIP-Seq_HFKS_Human1.00290904
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99790595
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.99556434
142GATA1_19941826_ChIP-Seq_K562_Human0.99532471
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.99473973
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98910702
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98581492
146TP53_22127205_ChIP-Seq_IMR90_Human0.96286244
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95609513
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94759995
149TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94523495
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93556868
151TP53_16413492_ChIP-PET_HCT116_Human0.92626801
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92464662
153CREB1_26743006_Chip-Seq_LNCaP_Human0.90439852
154STAT3_23295773_ChIP-Seq_U87_Human0.90436395
155TET1_21490601_ChIP-Seq_MESCs_Mouse0.90109278
156KLF4_19829295_ChIP-Seq_ESCs_Human0.90101446
157SMC4_20622854_ChIP-Seq_HELA_Human0.88922641
158TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88243191
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88131170
160KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86374126
161BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85804245
162SMAD3_21741376_ChIP-Seq_HESCs_Human0.85790992
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83264392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.72147110
2MP0005451_abnormal_body_composition3.46386856
3MP0005058_abnormal_lysosome_morphology3.41671077
4MP0003635_abnormal_synaptic_transmissio3.21928600
5MP0002837_dystrophic_cardiac_calcinosis3.14842168
6MP0003436_decreased_susceptibility_to3.10086654
7MP0003172_abnormal_lysosome_physiology3.00745656
8MP0003303_peritoneal_inflammation2.97977509
9MP0004270_analgesia2.93325779
10MP0000751_myopathy2.69068230
11MP0009840_abnormal_foam_cell2.54321212
12MP0008260_abnormal_autophagy2.51083591
13MP0003646_muscle_fatigue2.49852085
14MP0002063_abnormal_learning/memory/cond2.45394177
15MP0009046_muscle_twitch2.45310576
16MP0009780_abnormal_chondrocyte_physiolo2.39122446
17MP0009745_abnormal_behavioral_response2.34757289
18MP0002909_abnormal_adrenal_gland2.31680110
19MP0002822_catalepsy2.28842177
20MP0002064_seizures2.25902264
21MP0003191_abnormal_cellular_cholesterol2.24816634
22MP0004130_abnormal_muscle_cell2.23933738
23MP0003300_gastrointestinal_ulcer2.21992322
24MP0004145_abnormal_muscle_electrophysio2.09547244
25MP0004215_abnormal_myocardial_fiber2.07258423
26MP0003880_abnormal_central_pattern2.04292321
27MP0008569_lethality_at_weaning2.02109649
28MP0009278_abnormal_bone_marrow1.95419777
29MP0003329_amyloid_beta_deposits1.84669620
30MP0004084_abnormal_cardiac_muscle1.83597692
31MP0002572_abnormal_emotion/affect_behav1.79360417
32MP0004036_abnormal_muscle_relaxation1.79191273
33MP0005409_darkened_coat_color1.77511700
34MP0004858_abnormal_nervous_system1.77010254
35MP0005076_abnormal_cell_differentiation1.76742995
36MP0008961_abnormal_basal_metabolism1.75784283
37MP0005423_abnormal_somatic_nervous1.75565167
38MP0001968_abnormal_touch/_nociception1.75359181
39MP0002734_abnormal_mechanical_nocicepti1.74515389
40MP0002272_abnormal_nervous_system1.74357615
41MP0001849_ear_inflammation1.74110830
42MP0000685_abnormal_immune_system1.66170801
43MP0000569_abnormal_digit_pigmentation1.65122795
44MP0001486_abnormal_startle_reflex1.60063981
45MP0002419_abnormal_innate_immunity1.59636292
46MP0005025_abnormal_response_to1.59238194
47MP0004087_abnormal_muscle_fiber1.54151499
48MP0004233_abnormal_muscle_weight1.50896992
49MP0000749_muscle_degeneration1.49404003
50MP0004811_abnormal_neuron_physiology1.49382988
51MP0004947_skin_inflammation1.49342851
52MP0001440_abnormal_grooming_behavior1.48311965
53MP0005464_abnormal_platelet_physiology1.44773410
54MP0003137_abnormal_impulse_conducting1.44603485
55MP0001790_abnormal_immune_system1.43393291
56MP0005387_immune_system_phenotype1.43393291
57MP0003283_abnormal_digestive_organ1.42407337
58MP0003091_abnormal_cell_migration1.42113531
59MP0005360_urolithiasis1.41574098
60MP0002067_abnormal_sensory_capabilities1.41551099
61MP0004185_abnormal_adipocyte_glucose1.41457669
62MP0002139_abnormal_hepatobiliary_system1.40197065
63MP0001533_abnormal_skeleton_physiology1.38917087
64MP0000858_altered_metastatic_potential1.38311524
65MP0002269_muscular_atrophy1.38234779
66MP0004924_abnormal_behavior1.36786087
67MP0005386_behavior/neurological_phenoty1.36786087
68MP0002735_abnormal_chemical_nociception1.36627767
69MP0004885_abnormal_endolymph1.34637165
70MP0003633_abnormal_nervous_system1.34327354
71MP0000747_muscle_weakness1.34254158
72MP0003705_abnormal_hypodermis_morpholog1.33423569
73MP0004085_abnormal_heartbeat1.32326340
74MP0000013_abnormal_adipose_tissue1.31846635
75MP0001501_abnormal_sleep_pattern1.31606983
76MP0002733_abnormal_thermal_nociception1.30689977
77MP0005000_abnormal_immune_tolerance1.30002833
78MP0002089_abnormal_postnatal_growth/wei1.28621398
79MP0005620_abnormal_muscle_contractility1.28564633
80MP0003183_abnormal_peptide_metabolism1.28483447
81MP0005330_cardiomyopathy1.28350617
82MP0003763_abnormal_thymus_physiology1.27155597
83MP0005085_abnormal_gallbladder_physiolo1.23701992
84MP0003690_abnormal_glial_cell1.23427879
85MP0000955_abnormal_spinal_cord1.23364515
86MP0003724_increased_susceptibility_to1.22924571
87MP0005365_abnormal_bile_salt1.22637722
88MP0002933_joint_inflammation1.22347147
89MP0000778_abnormal_nervous_system1.22039477
90MP0002998_abnormal_bone_remodeling1.21923161
91MP0002184_abnormal_innervation1.21496391
92MP0001800_abnormal_humoral_immune1.21132291
93MP0001958_emphysema1.20904080
94MP0003252_abnormal_bile_duct1.19488896
95MP0003566_abnormal_cell_adhesion1.19384534
96MP0001835_abnormal_antigen_presentation1.19182669
97MP0004510_myositis1.19021413
98MP0001970_abnormal_pain_threshold1.17554247
99MP0005375_adipose_tissue_phenotype1.17250477
100MP0003453_abnormal_keratinocyte_physiol1.17234200
101MP0002557_abnormal_social/conspecific_i1.16112635
102MP0010329_abnormal_lipoprotein_level1.14960230
103MP0002972_abnormal_cardiac_muscle1.14801429
104MP0002736_abnormal_nociception_after1.12973709
105MP0002723_abnormal_immune_serum1.12215851
106MP0010155_abnormal_intestine_physiology1.12141191
107MP0003279_aneurysm1.10830181
108MP0003045_fibrosis1.10741462
109MP0008438_abnormal_cutaneous_collagen1.10429478
110MP0002066_abnormal_motor_capabilities/c1.10426535
111MP0002138_abnormal_hepatobiliary_system1.09912343
112MP0005083_abnormal_biliary_tract1.08551340
113MP0000759_abnormal_skeletal_muscle1.07234748
114MP0003879_abnormal_hair_cell1.06888023
115MP0003631_nervous_system_phenotype1.06344572
116MP0005187_abnormal_penis_morphology1.05751526
117MP0001348_abnormal_lacrimal_gland1.05027793
118MP0002420_abnormal_adaptive_immunity1.04839280
119MP0002249_abnormal_larynx_morphology1.04377073
120MP0000920_abnormal_myelination1.04197243
121MP0002971_abnormal_brown_adipose1.03471123
122MP0001819_abnormal_immune_cell1.03242424
123MP0002106_abnormal_muscle_physiology1.02639720
124MP0009333_abnormal_splenocyte_physiolog1.02190167
125MP0005535_abnormal_body_temperature1.01228243
126MP0004484_altered_response_of1.01127057
127MP0000604_amyloidosis1.00578645
128MP0002882_abnormal_neuron_morphology1.00077912
129MP0000609_abnormal_liver_physiology0.99894982
130MP0008775_abnormal_heart_ventricle0.98861714
131MP0000678_abnormal_parathyroid_gland0.98164015
132MP0006082_CNS_inflammation0.96350877
133MP0002452_abnormal_antigen_presenting0.94978437
134MP0001915_intracranial_hemorrhage0.93334139
135MP0008469_abnormal_protein_level0.92410710
136MP0008874_decreased_physiological_sensi0.92214136
137MP0003634_abnormal_glial_cell0.91917643
138MP0004043_abnormal_pH_regulation0.91066146
139MP0002405_respiratory_system_inflammati0.90704331
140MP0005166_decreased_susceptibility_to0.90213790
141MP0009785_altered_susceptibility_to0.89902524
142MP0001502_abnormal_circadian_rhythm0.89316329
143MP0001545_abnormal_hematopoietic_system0.86297659
144MP0005397_hematopoietic_system_phenotyp0.86297659
145MP0005369_muscle_phenotype0.86230986
146MP0002090_abnormal_vision0.85522972
147MP0010630_abnormal_cardiac_muscle0.85440950
148MP0005666_abnormal_adipose_tissue0.84189825
149MP0003828_pulmonary_edema0.84050554
150MP0000716_abnormal_immune_system0.83906481
151MP0002152_abnormal_brain_morphology0.83067103
152MP0000733_abnormal_muscle_development0.82203534
153MP0003656_abnormal_erythrocyte_physiolo0.81891115
154MP0001299_abnormal_eye_distance/0.80990132
155MP0003075_altered_response_to0.80974481
156MP0000767_abnormal_smooth_muscle0.80851834
157MP0001544_abnormal_cardiovascular_syste0.80650671
158MP0005385_cardiovascular_system_phenoty0.80650671
159MP0010234_abnormal_vibrissa_follicle0.80548373
160MP0002229_neurodegeneration0.80350377
161MP0006138_congestive_heart_failure0.79894755
162MP0002234_abnormal_pharynx_morphology0.79776596
163MP0005671_abnormal_response_to0.79487547
164MP0002398_abnormal_bone_marrow0.79284144
165MP0002078_abnormal_glucose_homeostasis0.78934781
166MP0002118_abnormal_lipid_homeostasis0.78785158
167MP0000003_abnormal_adipose_tissue0.78685844
168MP0001845_abnormal_inflammatory_respons0.77579728
169MP0001851_eye_inflammation0.77519166
170MP0002069_abnormal_eating/drinking_beha0.77343754
171MP0003866_abnormal_defecation0.74599683
172MP0005023_abnormal_wound_healing0.72590578
173MP0005257_abnormal_intraocular_pressure0.70389545

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.30121808
2Focal motor seizures (HP:0011153)3.82273903
3Exercise-induced myalgia (HP:0003738)3.69991972
4Action tremor (HP:0002345)3.68519745
5Focal seizures (HP:0007359)3.67455166
6Visual hallucinations (HP:0002367)3.61844826
7Dysmetric saccades (HP:0000641)3.57011148
8Sudden death (HP:0001699)3.47343391
9Complement deficiency (HP:0004431)3.41580818
10Systemic lupus erythematosus (HP:0002725)3.39499557
11Bundle branch block (HP:0011710)3.35033345
12Eczematoid dermatitis (HP:0000976)3.31153220
13Abnormality of complement system (HP:0005339)3.18671023
14Abnormality of the lower motor neuron (HP:0002366)3.12874604
15Hemorrhage of the eye (HP:0011885)3.06192689
16Obstructive sleep apnea (HP:0002870)3.01000663
17Ventricular fibrillation (HP:0001663)3.00067566
18Cerebral aneurysm (HP:0004944)2.96306703
19Impaired social interactions (HP:0000735)2.95631861
20Abnormal social behavior (HP:0012433)2.95631861
21Progressive cerebellar ataxia (HP:0002073)2.95163648
22Joint hemorrhage (HP:0005261)2.88437965
23Recurrent gram-negative bacterial infections (HP:0005420)2.88266724
24Difficulty running (HP:0009046)2.88100399
25Poor eye contact (HP:0000817)2.85174896
26Impaired vibration sensation in the lower limbs (HP:0002166)2.80577748
27Exercise-induced muscle cramps (HP:0003710)2.78166108
28Hyporeflexia of lower limbs (HP:0002600)2.76184523
29Supranuclear gaze palsy (HP:0000605)2.74595130
30Dysdiadochokinesis (HP:0002075)2.73902973
31Depression (HP:0000716)2.70287887
32Glomerulonephritis (HP:0000099)2.67571456
33Postural instability (HP:0002172)2.66908573
34Protrusio acetabuli (HP:0003179)2.63096868
35Hemiplegia (HP:0002301)2.62243128
36Ankle clonus (HP:0011448)2.58582428
37Dysostosis multiplex (HP:0000943)2.55640596
38Urinary bladder sphincter dysfunction (HP:0002839)2.50506195
39Neurofibrillary tangles (HP:0002185)2.49420876
40Intention tremor (HP:0002080)2.47936035
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.46950286
42Truncal ataxia (HP:0002078)2.45017131
43Syncope (HP:0001279)2.44734078
44Prolonged QT interval (HP:0001657)2.42403188
45Myoglobinuria (HP:0002913)2.41940271
46Urinary urgency (HP:0000012)2.41197161
47Insomnia (HP:0100785)2.41180931
48Generalized tonic-clonic seizures (HP:0002069)2.40798318
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40612197
50Urinary glycosaminoglycan excretion (HP:0003541)2.40023806
51Mucopolysacchariduria (HP:0008155)2.40023806
52Xanthomatosis (HP:0000991)2.39720929
53Epileptic encephalopathy (HP:0200134)2.37502425
54Calf muscle hypertrophy (HP:0008981)2.35085340
55Dysmetria (HP:0001310)2.34460842
56Thin bony cortex (HP:0002753)2.34379186
57Atonic seizures (HP:0010819)2.34166794
58Cellulitis (HP:0100658)2.33864891
59Gaze-evoked nystagmus (HP:0000640)2.33311028
60Genetic anticipation (HP:0003743)2.31373788
61Impaired smooth pursuit (HP:0007772)2.29737856
62Atrial fibrillation (HP:0005110)2.29728852
63Absence seizures (HP:0002121)2.29598451
64Abnormality of polysaccharide metabolism (HP:0011012)2.29293875
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29293875
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29293875
67Status epilepticus (HP:0002133)2.26432257
68Febrile seizures (HP:0002373)2.26373876
69Muscle hypertrophy of the lower extremities (HP:0008968)2.24127555
70Macroorchidism (HP:0000053)2.23758126
71Heart block (HP:0012722)2.23041818
72Myotonia (HP:0002486)2.22246757
73Purpura (HP:0000979)2.22233662
74Ventricular arrhythmia (HP:0004308)2.21993524
75Scanning speech (HP:0002168)2.21946942
76Colitis (HP:0002583)2.21511026
77Primary atrial arrhythmia (HP:0001692)2.21428310
78Increased connective tissue (HP:0009025)2.20237403
79Ketoacidosis (HP:0001993)2.19346645
80Anxiety (HP:0000739)2.15226233
81Gingivitis (HP:0000230)2.14229043
82Myopathic facies (HP:0002058)2.13056574
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12117360
84Abnormality of ocular smooth pursuit (HP:0000617)2.10934943
85Abnormal EKG (HP:0003115)2.09101053
86Stridor (HP:0010307)2.09012235
87Polygenic inheritance (HP:0010982)2.08885659
88Abnormality of macrophages (HP:0004311)2.08184969
89Torticollis (HP:0000473)2.07157257
90Deep venous thrombosis (HP:0002625)2.05985156
91Broad-based gait (HP:0002136)2.05883047
92Abnormal atrioventricular conduction (HP:0005150)2.04984005
93Atrioventricular block (HP:0001678)2.04830418
94Abnormality of the calf musculature (HP:0001430)2.03980801
95Lower limb amyotrophy (HP:0007210)2.03579124
96Vertebral compression fractures (HP:0002953)2.03431125
97Broad face (HP:0000283)2.03135292
98Supraventricular tachycardia (HP:0004755)2.02862476
99Ketosis (HP:0001946)2.02246790
100Neuronal loss in central nervous system (HP:0002529)2.02185838
101Termporal pattern (HP:0011008)2.01407793
102Insidious onset (HP:0003587)2.01407793
103Central scotoma (HP:0000603)2.00858707
104Ulnar bowing (HP:0003031)2.00417836
105Spastic gait (HP:0002064)2.00231441
106Hyperacusis (HP:0010780)2.00074709
107Gastrointestinal infarctions (HP:0005244)1.99896658
108Abnormality of skeletal muscle fiber size (HP:0012084)1.99868508
109Upper limb amyotrophy (HP:0009129)1.99742839
110Distal upper limb amyotrophy (HP:0007149)1.99742839
111Supraventricular arrhythmia (HP:0005115)1.98868796
112Increased variability in muscle fiber diameter (HP:0003557)1.98532899
113Flat acetabular roof (HP:0003180)1.98316558
114Hemiparesis (HP:0001269)1.98161993
115Distal lower limb amyotrophy (HP:0008944)1.98012281
116Increased IgE level (HP:0003212)1.97270899
117Dialeptic seizures (HP:0011146)1.96805236
118Cerebral inclusion bodies (HP:0100314)1.96491114
119Pheochromocytoma (HP:0002666)1.96272354
120Resting tremor (HP:0002322)1.95442778
121Aneurysm (HP:0002617)1.94753875
122Impaired vibratory sensation (HP:0002495)1.93930635
123Annular pancreas (HP:0001734)1.93192470
124Disproportionate tall stature (HP:0001519)1.93058543
125Pointed chin (HP:0000307)1.92802667
126Tetraplegia (HP:0002445)1.92790684
127EMG: neuropathic changes (HP:0003445)1.92483383
128Asymmetric septal hypertrophy (HP:0001670)1.91465224
129Myositis (HP:0100614)1.90583001
130Hypercholesterolemia (HP:0003124)1.90551778
131Recurrent abscess formation (HP:0002722)1.88997364
132Abnormality of the Achilles tendon (HP:0005109)1.88953749
133Broad metatarsal (HP:0001783)1.88916252
134Polycythemia (HP:0001901)1.88167606
135Amyloidosis (HP:0011034)1.88103149
136Prolonged partial thromboplastin time (HP:0003645)1.87543853
137Rapidly progressive (HP:0003678)1.86900082
138Abnormality of the common coagulation pathway (HP:0010990)1.86835315
139Abnormality of the fingertips (HP:0001211)1.86617739
140Elfin facies (HP:0004428)1.86117302
141Focal dystonia (HP:0004373)1.85972830
142Peritonitis (HP:0002586)1.85838490
143EMG: myopathic abnormalities (HP:0003458)1.85062444
144Onion bulb formation (HP:0003383)1.84837195
145Abnormality of saccadic eye movements (HP:0000570)1.84800370
146Achilles tendon contracture (HP:0001771)1.83676305
147Drooling (HP:0002307)1.83064240
148Excessive salivation (HP:0003781)1.83064240
149Loss of speech (HP:0002371)1.82729673
150Abnormality of the thoracic spine (HP:0100711)1.82709333
151Hamartoma of the eye (HP:0010568)1.82396763
152Neoplasm of the heart (HP:0100544)1.81437802
153Recurrent bacterial skin infections (HP:0005406)1.81198424
154Gingival bleeding (HP:0000225)1.81108444
155Ventricular tachycardia (HP:0004756)1.80182824
156Lower limb muscle weakness (HP:0007340)1.77854320
157Mitral regurgitation (HP:0001653)1.77712160
158Hypsarrhythmia (HP:0002521)1.77675638
159Cervical subluxation (HP:0003308)1.77230757
160Nephritis (HP:0000123)1.77155273
161Distal lower limb muscle weakness (HP:0009053)1.76851754
162Abnormal eating behavior (HP:0100738)1.76555306
163Myocardial infarction (HP:0001658)1.74304980
164Hypertriglyceridemia (HP:0002155)1.74146540
165Mitral stenosis (HP:0001718)1.73464860
166Thoracic kyphosis (HP:0002942)1.73292914
167Emphysema (HP:0002097)1.72762357
168Biconcave vertebral bodies (HP:0004586)1.72161962
169Reticulocytosis (HP:0001923)1.72130398
170Segmental peripheral demyelination/remyelination (HP:0003481)1.70706484
171Gastrointestinal inflammation (HP:0004386)1.68384864
172Obstructive lung disease (HP:0006536)1.68009020
173Chronic obstructive pulmonary disease (HP:0006510)1.68009020
174Turricephaly (HP:0000262)1.67689043
175Epistaxis (HP:0000421)1.66337772
176Increased cerebral lipofuscin (HP:0011813)1.66126423
177Hyperlipoproteinemia (HP:0010980)1.65882323
178Orchitis (HP:0100796)1.62913417
179Menorrhagia (HP:0000132)1.61620218
180Slow saccadic eye movements (HP:0000514)1.61401501
181Joint stiffness (HP:0001387)1.60828375
182Metaphyseal cupping (HP:0003021)1.59936449
183Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59616335
184Meningitis (HP:0001287)1.59382881
185Increased serum ferritin (HP:0003281)1.59302987
186Hypercortisolism (HP:0001578)1.58754992
187Hand muscle atrophy (HP:0009130)1.58138518
188Abnormal gallbladder physiology (HP:0012438)1.57797788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.09178884
2ERN12.98588174
3TRIB32.89729810
4NTRK32.83578480
5PRKD32.55125492
6EPHA42.46295048
7MAP3K42.40750821
8MARK12.33480932
9PHKG22.14003866
10PHKG12.14003866
11MAP2K32.13064531
12RIPK12.12794130
13PAK62.12416458
14DAPK22.03346535
15CAMKK12.00767615
16SMG11.92460390
17LMTK21.90387659
18MAP4K11.88856821
19KSR21.82606403
20PKN21.80377969
21MINK11.77227123
22CDK121.75491052
23NTRK21.70596198
24TTN1.67589451
25MAP3K111.65743396
26STK381.63617524
27MAP2K41.61500534
28BLK1.51503910
29CAMK1G1.48744629
30TYRO31.40026191
31NTRK11.39901697
32TYK21.35608129
33ICK1.35240047
34SIK21.34539254
35RET1.33427178
36PRKCH1.30566125
37PDK31.24838408
38PDK41.24838408
39KSR11.22281935
40MAP3K71.22197493
41PDGFRA1.21584684
42TAOK11.21148062
43IRAK31.20926835
44SIK11.20448407
45TNK21.19292392
46CDK51.17458561
47ZAP701.16699430
48DMPK1.15079886
49PRKD21.15036087
50EPHB11.13925126
51FGFR21.13609981
52MAP3K31.10561713
53TBK11.08021208
54NEK11.07622824
55SGK31.07531800
56MAP3K21.04240994
57CAMKK21.04114780
58PINK11.02017434
59PAK31.01793475
60TAOK21.01488412
61CAMK1D0.99054170
62GRK60.98121514
63MAP3K60.95035921
64EEF2K0.95008942
65CDC42BPA0.92358028
66WNK10.91721976
67STK110.90234369
68DYRK1B0.86626726
69MAP2K70.86600354
70PDK10.85813253
71CAMK10.85720584
72ALK0.85139727
73MAPK110.83950953
74PTK60.83768643
75SGK2230.82967994
76SGK4940.82967994
77CSK0.81904484
78JAK30.81869666
79MARK20.81178791
80UHMK10.81032853
81PDPK10.80730464
82RPS6KC10.78074133
83RPS6KL10.78074133
84SGK20.77888128
85OBSCN0.75144960
86FGFR40.74533132
87PRKAA10.74458607
88MTOR0.73988806
89CAMK40.73899359
90MAP3K100.73772611
91MAP3K140.73626549
92PRPF4B0.73411474
93PRKCG0.72711062
94IRAK40.70697509
95HCK0.67025105
96BTK0.66013536
97PTK2B0.65936035
98INSRR0.65715391
99PRKD10.65714019
100SGK10.65576833
101DDR20.65249473
102SCYL20.65102867
103ARAF0.64518328
104DAPK10.61279541
105LATS20.60502925
106MAPK120.59900713
107HIPK20.59856724
108RPS6KA30.59814315
109MAP3K10.58187916
110RPS6KA60.57532266
111IKBKE0.56128722
112JAK10.55824750
113SYK0.55382662
114BMX0.54758721
115ROCK10.53845027
116CSF1R0.53376419
117TESK20.52454399
118MAPK70.52376897
119RIPK40.52260211
120PRKCZ0.51991566
121FER0.51570897
122MAP3K130.51485350
123CDK150.51065611
124MAPK130.50613443
125FGR0.50521172
126MAPK150.50259497
127CAMK2A0.50215320
128CDK180.48452002
129ERBB20.48149763
130PDGFRB0.47461555
131IRAK20.46041888
132RPS6KA20.45980267
133TNIK0.45957479
134FYN0.45783317
135FGFR30.45483640
136MOS0.44014005
137PKN10.43695500
138FES0.43434197
139JAK20.42007708
140PRKACG0.40407784
141MAP2K20.40330861
142MAP2K60.39942227
143CDK40.39901135
144PTK20.39806971
145CDK11A0.39302887
146LCK0.39277363
147LRRK20.37797872
148PRKAA20.37545219
149MAPK40.36717615

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.02942202
2Other glycan degradation_Homo sapiens_hsa005112.83475069
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30118402
4Complement and coagulation cascades_Homo sapiens_hsa046102.11716508
5Nicotine addiction_Homo sapiens_hsa050331.89655420
6Circadian entrainment_Homo sapiens_hsa047131.89326571
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88393968
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86074386
9Synaptic vesicle cycle_Homo sapiens_hsa047211.82287513
10Long-term potentiation_Homo sapiens_hsa047201.81046122
11GABAergic synapse_Homo sapiens_hsa047271.76756354
12Olfactory transduction_Homo sapiens_hsa047401.74454164
13Glutamatergic synapse_Homo sapiens_hsa047241.73742089
14B cell receptor signaling pathway_Homo sapiens_hsa046621.69671442
15Staphylococcus aureus infection_Homo sapiens_hsa051501.69441529
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67880005
17Insulin secretion_Homo sapiens_hsa049111.67801896
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.65640998
19Acute myeloid leukemia_Homo sapiens_hsa052211.60338377
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59301799
21Osteoclast differentiation_Homo sapiens_hsa043801.57997399
22Salivary secretion_Homo sapiens_hsa049701.56715570
23Gastric acid secretion_Homo sapiens_hsa049711.55936952
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55786779
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55561957
26Morphine addiction_Homo sapiens_hsa050321.55221802
27Type II diabetes mellitus_Homo sapiens_hsa049301.54861701
28Arginine biosynthesis_Homo sapiens_hsa002201.52721057
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47492748
30Amphetamine addiction_Homo sapiens_hsa050311.41098052
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40702061
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39718294
33Dilated cardiomyopathy_Homo sapiens_hsa054141.38324160
34Chronic myeloid leukemia_Homo sapiens_hsa052201.36546017
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36073019
36Cholinergic synapse_Homo sapiens_hsa047251.35932122
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34244667
38Bile secretion_Homo sapiens_hsa049761.34005584
39Dopaminergic synapse_Homo sapiens_hsa047281.33762083
40Oxytocin signaling pathway_Homo sapiens_hsa049211.32906910
41Renin secretion_Homo sapiens_hsa049241.28120879
42Notch signaling pathway_Homo sapiens_hsa043301.23945362
43Leishmaniasis_Homo sapiens_hsa051401.17656778
44Calcium signaling pathway_Homo sapiens_hsa040201.15841572
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14808603
46Fatty acid degradation_Homo sapiens_hsa000711.11701070
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.11672041
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10657041
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10379107
50GnRH signaling pathway_Homo sapiens_hsa049121.08548000
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07790022
52Butanoate metabolism_Homo sapiens_hsa006501.06965247
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04922772
54Glucagon signaling pathway_Homo sapiens_hsa049221.04810538
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03355878
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02769399
57cAMP signaling pathway_Homo sapiens_hsa040241.01782866
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01459274
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.01295320
60Cardiac muscle contraction_Homo sapiens_hsa042601.00154887
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99707748
62Pertussis_Homo sapiens_hsa051330.98021826
63Estrogen signaling pathway_Homo sapiens_hsa049150.97932433
64Pancreatic cancer_Homo sapiens_hsa052120.97565770
65Propanoate metabolism_Homo sapiens_hsa006400.97330824
66Glioma_Homo sapiens_hsa052140.97137401
67Fatty acid metabolism_Homo sapiens_hsa012120.97077927
68Fructose and mannose metabolism_Homo sapiens_hsa000510.96666809
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96653350
70Gap junction_Homo sapiens_hsa045400.95968167
71T cell receptor signaling pathway_Homo sapiens_hsa046600.95918474
72Long-term depression_Homo sapiens_hsa047300.95094622
73Taste transduction_Homo sapiens_hsa047420.94940187
74Prolactin signaling pathway_Homo sapiens_hsa049170.94036218
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93787560
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93625412
77Cocaine addiction_Homo sapiens_hsa050300.92285561
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90776052
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90111953
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88703824
81Fatty acid biosynthesis_Homo sapiens_hsa000610.88624963
82mTOR signaling pathway_Homo sapiens_hsa041500.88021842
83Tuberculosis_Homo sapiens_hsa051520.88013027
84Insulin resistance_Homo sapiens_hsa049310.87906772
85Lysosome_Homo sapiens_hsa041420.87759789
86PPAR signaling pathway_Homo sapiens_hsa033200.87693130
87Phenylalanine metabolism_Homo sapiens_hsa003600.86790084
88Insulin signaling pathway_Homo sapiens_hsa049100.86118102
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86060294
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.85477743
91Hepatitis C_Homo sapiens_hsa051600.85138470
92TNF signaling pathway_Homo sapiens_hsa046680.82591816
93Amoebiasis_Homo sapiens_hsa051460.82192870
94Dorso-ventral axis formation_Homo sapiens_hsa043200.81787017
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.81743634
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80724598
97Toxoplasmosis_Homo sapiens_hsa051450.80067996
98Pancreatic secretion_Homo sapiens_hsa049720.79068833
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.76629764
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75526227
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.74577061
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.73298889
103Chemokine signaling pathway_Homo sapiens_hsa040620.72803351
104Thyroid hormone synthesis_Homo sapiens_hsa049180.71167467
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71151892
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71082903
107AMPK signaling pathway_Homo sapiens_hsa041520.70266392
108Platelet activation_Homo sapiens_hsa046110.69770007
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69448055
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69281833
111Bladder cancer_Homo sapiens_hsa052190.69088650
112ErbB signaling pathway_Homo sapiens_hsa040120.67865164
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65597322
114Focal adhesion_Homo sapiens_hsa045100.64818054
115Lysine degradation_Homo sapiens_hsa003100.64675633
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.64333437
117Influenza A_Homo sapiens_hsa051640.63630277
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63007689
119Hepatitis B_Homo sapiens_hsa051610.62240923
120Melanogenesis_Homo sapiens_hsa049160.61856384
121Axon guidance_Homo sapiens_hsa043600.60174681
122VEGF signaling pathway_Homo sapiens_hsa043700.59807788
123FoxO signaling pathway_Homo sapiens_hsa040680.59065754
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.58341408
125Galactose metabolism_Homo sapiens_hsa000520.58136885
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.57117928
127Non-small cell lung cancer_Homo sapiens_hsa052230.56608000
128Endometrial cancer_Homo sapiens_hsa052130.56219273
129Choline metabolism in cancer_Homo sapiens_hsa052310.55739959
130Carbon metabolism_Homo sapiens_hsa012000.54978516
131Inositol phosphate metabolism_Homo sapiens_hsa005620.54732584
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53908715
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53592993
134Malaria_Homo sapiens_hsa051440.53436958
135Tryptophan metabolism_Homo sapiens_hsa003800.52421439
136Serotonergic synapse_Homo sapiens_hsa047260.51957049
137Salmonella infection_Homo sapiens_hsa051320.51922625
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.51342186
139HIF-1 signaling pathway_Homo sapiens_hsa040660.51141504
140Pyruvate metabolism_Homo sapiens_hsa006200.50875002
141ABC transporters_Homo sapiens_hsa020100.50390528
142Pentose phosphate pathway_Homo sapiens_hsa000300.50251572
143MAPK signaling pathway_Homo sapiens_hsa040100.49577392
144Apoptosis_Homo sapiens_hsa042100.49416056
145Circadian rhythm_Homo sapiens_hsa047100.48583648
146Colorectal cancer_Homo sapiens_hsa052100.48206124
147Measles_Homo sapiens_hsa051620.45641422
148Proteoglycans in cancer_Homo sapiens_hsa052050.45228852
149Glycerolipid metabolism_Homo sapiens_hsa005610.44646197
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43978178
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42565998
152Prion diseases_Homo sapiens_hsa050200.42383111
153Rap1 signaling pathway_Homo sapiens_hsa040150.40948207
154Renal cell carcinoma_Homo sapiens_hsa052110.39493119
155Endocytosis_Homo sapiens_hsa041440.39302163

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »