PPP5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)5.85268275
2DNA unwinding involved in DNA replication (GO:0006268)5.43285254
3folic acid-containing compound biosynthetic process (GO:0009396)4.95259319
4Golgi transport vesicle coating (GO:0048200)4.87027333
5COPI coating of Golgi vesicle (GO:0048205)4.87027333
6DNA strand elongation involved in DNA replication (GO:0006271)4.83071329
7IMP biosynthetic process (GO:0006188)4.72483219
8nucleobase biosynthetic process (GO:0046112)4.70481628
9mitotic chromosome condensation (GO:0007076)4.62662371
10DNA strand elongation (GO:0022616)4.54691349
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.45137009
12maturation of SSU-rRNA (GO:0030490)4.42733675
13nuclear pore complex assembly (GO:0051292)4.40244706
14DNA replication initiation (GO:0006270)4.33787872
15peptidyl-arginine omega-N-methylation (GO:0035247)4.27859601
16purine nucleobase biosynthetic process (GO:0009113)4.27753091
17telomere maintenance via semi-conservative replication (GO:0032201)4.24605014
18IMP metabolic process (GO:0046040)4.15226776
19regulation of translational termination (GO:0006449)4.14867856
20regulation of mammary gland epithelial cell proliferation (GO:0033599)4.07850410
21folic acid metabolic process (GO:0046655)4.06491567
22proline biosynthetic process (GO:0006561)4.03805125
23ribosomal small subunit assembly (GO:0000028)4.01165610
24mitotic nuclear envelope disassembly (GO:0007077)3.99889614
25protein retention in ER lumen (GO:0006621)3.91888679
26DNA deamination (GO:0045006)3.91736676
27regulation of mitochondrial translation (GO:0070129)3.80854545
28nuclear envelope disassembly (GO:0051081)3.78144286
29membrane disassembly (GO:0030397)3.78144286
30nuclear pore organization (GO:0006999)3.77022843
31DNA replication checkpoint (GO:0000076)3.76777986
32negative regulation of RNA splicing (GO:0033119)3.75297647
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.75172502
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.75035781
35regulation of translational fidelity (GO:0006450)3.72306930
36somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60681905
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.60681905
38histone arginine methylation (GO:0034969)3.57947901
39postreplication repair (GO:0006301)3.55398970
40ribosome biogenesis (GO:0042254)3.51832946
41peptidyl-arginine methylation (GO:0018216)3.51575061
42peptidyl-arginine N-methylation (GO:0035246)3.51575061
43DNA duplex unwinding (GO:0032508)3.49937314
44translesion synthesis (GO:0019985)3.47496994
45DNA geometric change (GO:0032392)3.46185542
46negative regulation of mRNA processing (GO:0050686)3.46105948
47protein localization to kinetochore (GO:0034501)3.44464925
48nucleosome disassembly (GO:0006337)3.43453490
49protein-DNA complex disassembly (GO:0032986)3.43453490
50cellular protein complex localization (GO:0034629)3.42029936
51protein maturation by protein folding (GO:0022417)3.40625171
52establishment of integrated proviral latency (GO:0075713)3.40574293
53translational elongation (GO:0006414)3.39950117
54DNA replication-dependent nucleosome organization (GO:0034723)3.39397018
55DNA replication-dependent nucleosome assembly (GO:0006335)3.39397018
56mitotic G1 DNA damage checkpoint (GO:0031571)3.39002477
57negative regulation of cell size (GO:0045792)3.36577475
58translational initiation (GO:0006413)3.35819512
59telomere maintenance via recombination (GO:0000722)3.34159068
60viral transcription (GO:0019083)3.32612896
61glycine metabolic process (GO:0006544)3.32518851
62pore complex assembly (GO:0046931)3.26452838
63regulation of oxidative phosphorylation (GO:0002082)3.24927250
64translational termination (GO:0006415)3.21847979
65mitotic nuclear envelope reassembly (GO:0007084)3.21762868
66nuclear envelope reassembly (GO:0031468)3.21762868
67telomere maintenance via telomere lengthening (GO:0010833)3.18512556
68negative regulation of mRNA metabolic process (GO:1903312)3.17587191
69regulation of mitotic spindle organization (GO:0060236)3.17336789
70mitotic recombination (GO:0006312)3.14861827
71pteridine-containing compound biosynthetic process (GO:0042559)3.13849090
72chromosome condensation (GO:0030261)3.07061314
73ribosomal large subunit biogenesis (GO:0042273)3.06031551
74ribonucleoprotein complex biogenesis (GO:0022613)3.04472672
75ribosome assembly (GO:0042255)2.99458172
76DNA double-strand break processing (GO:0000729)2.98342218
77adherens junction assembly (GO:0034333)2.97179917
78pre-miRNA processing (GO:0031054)2.95796754
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95764421
80intra-S DNA damage checkpoint (GO:0031573)2.95535964
81base-excision repair (GO:0006284)2.95177389
82nuclear envelope organization (GO:0006998)2.95161916
83L-serine metabolic process (GO:0006563)2.95028082
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94751056
85positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.91497672
86histone H2A acetylation (GO:0043968)2.90303268
87protein complex localization (GO:0031503)2.90136554
88tetrahydrofolate metabolic process (GO:0046653)2.89176285
89spliceosomal snRNP assembly (GO:0000387)2.88226115
90mitotic sister chromatid segregation (GO:0000070)2.87308450
91regulation of NFAT protein import into nucleus (GO:0051532)2.86052287
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82196486
93tricarboxylic acid cycle (GO:0006099)2.81945288
94pentose-phosphate shunt (GO:0006098)2.81926860
95heterochromatin organization (GO:0070828)2.81081278
96pseudouridine synthesis (GO:0001522)2.80368020
97nucleobase-containing small molecule interconversion (GO:0015949)2.80193727
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.79951750
99tRNA aminoacylation for protein translation (GO:0006418)2.79718250
100focal adhesion assembly (GO:0048041)2.78442790
101cell-substrate adherens junction assembly (GO:0007045)2.78442790
102regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77440009
103regulation of RNA export from nucleus (GO:0046831)2.76933051
104RNA stabilization (GO:0043489)2.75981081
105mRNA stabilization (GO:0048255)2.75981081
106peptidyl-lysine dimethylation (GO:0018027)2.75681309
107DNA topological change (GO:0006265)2.75512443
108mRNA splicing, via spliceosome (GO:0000398)2.75207389
109RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75207389
110mitotic G1/S transition checkpoint (GO:0044819)2.74490758
111rRNA transcription (GO:0009303)2.74483082
112proline metabolic process (GO:0006560)2.74316554
113protein localization to chromosome, centromeric region (GO:0071459)2.73857975
114mitochondrial DNA metabolic process (GO:0032042)2.73005069
115mitotic sister chromatid cohesion (GO:0007064)2.72795311
116tRNA aminoacylation (GO:0043039)2.72256957
117amino acid activation (GO:0043038)2.72256957
118maternal placenta development (GO:0001893)2.71351963
119DNA conformation change (GO:0071103)2.71218624
120regulation of spindle organization (GO:0090224)2.70578994
121folic acid-containing compound metabolic process (GO:0006760)2.70574544
122RNA splicing, via transesterification reactions (GO:0000375)2.70337553
123apoptotic process involved in morphogenesis (GO:0060561)2.69514162
124intracellular estrogen receptor signaling pathway (GO:0030520)2.69031310
125termination of RNA polymerase II transcription (GO:0006369)2.69010864
126viral mRNA export from host cell nucleus (GO:0046784)2.68857678
1273-UTR-mediated mRNA stabilization (GO:0070935)2.67744272
128protein export from nucleus (GO:0006611)2.67177542
129oxidative phosphorylation (GO:0006119)2.67074829
130serine family amino acid biosynthetic process (GO:0009070)2.66153664
131establishment of viral latency (GO:0019043)2.65770131
132spliceosomal tri-snRNP complex assembly (GO:0000244)2.65653801
133fatty acid homeostasis (GO:0055089)2.64538947
134rRNA processing (GO:0006364)2.64453628
135glucocorticoid receptor signaling pathway (GO:0042921)2.60205937
136mitotic metaphase plate congression (GO:0007080)2.59591308
137positive regulation of DNA-dependent DNA replication (GO:2000105)2.59435933
138oxaloacetate metabolic process (GO:0006107)2.59180160
139regulation of histone H3-K9 methylation (GO:0051570)2.58676624
140cellular protein complex disassembly (GO:0043624)2.58563701
141DNA packaging (GO:0006323)2.58261609
142mitochondrial fusion (GO:0008053)2.58128096
143dosage compensation (GO:0007549)2.58060584
144glycolytic process (GO:0006096)2.57844241
145G1 DNA damage checkpoint (GO:0044783)2.57839449
146snRNA metabolic process (GO:0016073)2.57736469
147pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.57255179
148protein complex disassembly (GO:0043241)2.56983867
149sister chromatid segregation (GO:0000819)2.56558703
150rRNA metabolic process (GO:0016072)2.55794335
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55582618
152regulation of nucleobase-containing compound transport (GO:0032239)2.52120255
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51905106
154negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50562732
155protein localization to endosome (GO:0036010)2.49837768
156chromatin assembly (GO:0031497)2.49048219
157regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.47846203
158positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.47846203
159glucose catabolic process (GO:0006007)2.46358716
160DNA synthesis involved in DNA repair (GO:0000731)2.45696283
161NADPH regeneration (GO:0006740)2.45379977

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.03249650
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.25736302
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.70029834
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.97934109
5* MYC_22102868_ChIP-Seq_BL_Human2.81541339
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75137471
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56961378
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39352843
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32317912
10XRN2_22483619_ChIP-Seq_HELA_Human2.22145366
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.21478358
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06369556
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04897936
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01429353
15CIITA_25753668_ChIP-Seq_RAJI_Human1.98803906
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.97512892
17VDR_21846776_ChIP-Seq_THP-1_Human1.93304612
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91996064
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88580644
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.78737846
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78327437
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76859642
23* GABP_19822575_ChIP-Seq_HepG2_Human1.71145880
24* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67641078
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65724295
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64894406
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60221227
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59052261
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58684106
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57745949
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56999308
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56434284
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55155772
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54343780
35AR_21909140_ChIP-Seq_LNCAP_Human1.54243131
36* E2F1_21310950_ChIP-Seq_MCF-7_Human1.48820605
37FOXP3_21729870_ChIP-Seq_TREG_Human1.46873446
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46574145
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46149342
40VDR_23849224_ChIP-Seq_CD4+_Human1.45786151
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44252375
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43883587
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.43263906
44* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43105221
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.42406546
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41916216
47CLOCK_20551151_ChIP-Seq_293T_Human1.40803567
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38169780
49LXR_22292898_ChIP-Seq_THP-1_Human1.38147470
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37298879
51CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36865307
52KDM5A_27292631_Chip-Seq_BREAST_Human1.32599695
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31959570
54DCP1A_22483619_ChIP-Seq_HELA_Human1.30243626
55* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29998664
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27891641
57TTF2_22483619_ChIP-Seq_HELA_Human1.26553137
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26359653
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26126453
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.25972306
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24377560
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22009421
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21496722
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19226575
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19037145
66* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18471955
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18456486
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18274559
69ZNF263_19887448_ChIP-Seq_K562_Human1.18197790
70* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17845003
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17426331
72TCF7_22412390_ChIP-Seq_EML_Mouse1.17357397
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17064894
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16238360
75UTX_26944678_Chip-Seq_JUKART_Human1.15847579
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15828647
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15808819
78* KDM2B_26808549_Chip-Seq_DND41_Human1.15612423
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15163094
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12917650
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12729148
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12614249
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12135317
84P68_20966046_ChIP-Seq_HELA_Human1.11974682
85KDM2B_26808549_Chip-Seq_K562_Human1.11008099
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10773807
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10580474
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09130859
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07186018
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06203053
91TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05526525
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05399455
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04810774
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03875100
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03850657
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.03357675
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.03355508
98MAF_26560356_Chip-Seq_TH1_Human1.03126937
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02695757
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02487850
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01962654
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01677498
103ATF3_27146783_Chip-Seq_COLON_Human1.01417878
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00633127
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00570936
106SMC4_20622854_ChIP-Seq_HELA_Human1.00368434
107CREB1_26743006_Chip-Seq_LNCaP_Human1.00269861
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.00227572
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.99889636
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99883295
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99703420
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99496403
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99406877
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.99200223
115TFEB_21752829_ChIP-Seq_HELA_Human0.98885941
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97761170
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97459503
118BCL6_27268052_Chip-Seq_Bcells_Human0.97331246
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97305783
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96922660
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96414055
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96302376
123RACK7_27058665_Chip-Seq_MCF-7_Human0.95401041
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95000415
125PHF8_20622854_ChIP-Seq_HELA_Human0.94331880
126KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93640105
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93198329
128MAF_26560356_Chip-Seq_TH2_Human0.93040602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.34052226
2MP0003111_abnormal_nucleus_morphology3.79396314
3MP0004957_abnormal_blastocyst_morpholog3.75627889
4MP0010094_abnormal_chromosome_stability3.75061258
5* MP0003077_abnormal_cell_cycle3.22639137
6MP0002396_abnormal_hematopoietic_system3.05546021
7MP0010352_gastrointestinal_tract_polyps3.04685402
8MP0001730_embryonic_growth_arrest2.65911519
9MP0002877_abnormal_melanocyte_morpholog2.54817873
10MP0005623_abnormal_meninges_morphology2.54130134
11MP0003806_abnormal_nucleotide_metabolis2.47505038
12MP0003123_paternal_imprinting2.45273660
13MP0003705_abnormal_hypodermis_morpholog2.35711246
14MP0005451_abnormal_body_composition2.26557501
15MP0003283_abnormal_digestive_organ2.14859009
16MP0008058_abnormal_DNA_repair2.13284198
17MP0008057_abnormal_DNA_replication2.12647866
18MP0000350_abnormal_cell_proliferation2.09994961
19MP0008007_abnormal_cellular_replicative2.06799429
20MP0009840_abnormal_foam_cell2.00876824
21MP0002653_abnormal_ependyma_morphology1.92480824
22MP0004185_abnormal_adipocyte_glucose1.92041066
23MP0002080_prenatal_lethality1.82640522
24MP0001697_abnormal_embryo_size1.80682818
25MP0008932_abnormal_embryonic_tissue1.77911153
26MP0004084_abnormal_cardiac_muscle1.76960799
27MP0004808_abnormal_hematopoietic_stem1.74741663
28MP0004858_abnormal_nervous_system1.71592616
29MP0002269_muscular_atrophy1.71257812
30MP0002089_abnormal_postnatal_growth/wei1.69814333
31MP0005380_embryogenesis_phenotype1.66537776
32MP0001672_abnormal_embryogenesis/_devel1.66537776
33MP0008438_abnormal_cutaneous_collagen1.66281004
34MP0002249_abnormal_larynx_morphology1.63952993
35MP0000003_abnormal_adipose_tissue1.63457618
36MP0010234_abnormal_vibrissa_follicle1.62626113
37MP0006036_abnormal_mitochondrial_physio1.61361032
38MP0001346_abnormal_lacrimal_gland1.61192975
39MP0003984_embryonic_growth_retardation1.60073119
40MP0004233_abnormal_muscle_weight1.58965462
41MP0005257_abnormal_intraocular_pressure1.58581102
42MP0004272_abnormal_basement_membrane1.58429541
43MP0000371_diluted_coat_color1.58078514
44MP0002088_abnormal_embryonic_growth/wei1.57376729
45MP0004197_abnormal_fetal_growth/weight/1.52314828
46MP0000313_abnormal_cell_death1.50071805
47MP0001661_extended_life_span1.49545388
48MP0002084_abnormal_developmental_patter1.48529547
49MP0000747_muscle_weakness1.47971519
50MP0002086_abnormal_extraembryonic_tissu1.47838480
51MP0000490_abnormal_crypts_of1.46437970
52MP0003646_muscle_fatigue1.46420592
53MP0000358_abnormal_cell_content/1.44384419
54MP0004133_heterotaxia1.44360671
55MP0003221_abnormal_cardiomyocyte_apopto1.42714783
56MP0002019_abnormal_tumor_incidence1.42643131
57MP0000751_myopathy1.42040241
58MP0002085_abnormal_embryonic_tissue1.41930262
59MP0003385_abnormal_body_wall1.41301636
60MP0000678_abnormal_parathyroid_gland1.39709738
61MP0000733_abnormal_muscle_development1.39598811
62MP0008961_abnormal_basal_metabolism1.38416996
63MP0005330_cardiomyopathy1.31522945
64MP0004859_abnormal_synaptic_plasticity1.30279857
65MP0009672_abnormal_birth_weight1.28989116
66MP0005501_abnormal_skin_physiology1.28440738
67MP0010307_abnormal_tumor_latency1.27698043
68MP0005397_hematopoietic_system_phenotyp1.27267773
69MP0001545_abnormal_hematopoietic_system1.27267773
70MP0008260_abnormal_autophagy1.24649715
71MP0000703_abnormal_thymus_morphology1.23801879
72MP0003942_abnormal_urinary_system1.23692580
73MP0010030_abnormal_orbit_morphology1.22057538
74MP0000566_synostosis1.21526427
75MP0003119_abnormal_digestive_system1.20597039
76MP0003567_abnormal_fetal_cardiomyocyte1.19723186
77MP0001849_ear_inflammation1.17106809
78MP0001348_abnormal_lacrimal_gland1.16830487
79MP0005266_abnormal_metabolism1.13513962
80MP0002697_abnormal_eye_size1.13040637
81MP0005076_abnormal_cell_differentiation1.12833034
82MP0003115_abnormal_respiratory_system1.11883294
83MP0010630_abnormal_cardiac_muscle1.08972924
84MP0006035_abnormal_mitochondrial_morpho1.08637664
85MP0005360_urolithiasis1.07590529
86MP0009278_abnormal_bone_marrow1.07000089
87MP0000534_abnormal_ureter_morphology1.05304203
88MP0003786_premature_aging1.04202862
89MP0000749_muscle_degeneration1.02467606
90MP0002722_abnormal_immune_system1.02012314
91MP0004087_abnormal_muscle_fiber0.99064559
92MP0005375_adipose_tissue_phenotype0.98125749
93MP0002398_abnormal_bone_marrow0.98075770
94MP0003315_abnormal_perineum_morphology0.97934250
95MP0003566_abnormal_cell_adhesion0.97842003
96MP0005023_abnormal_wound_healing0.97684692
97MP0001915_intracranial_hemorrhage0.97651544
98MP0000689_abnormal_spleen_morphology0.96199249
99MP0003861_abnormal_nervous_system0.95155168
100MP0003763_abnormal_thymus_physiology0.94587294
101MP0000685_abnormal_immune_system0.93286353
102MP0003890_abnormal_embryonic-extraembry0.92926825
103MP0000537_abnormal_urethra_morphology0.92321060
104MP0002796_impaired_skin_barrier0.91468130
105MP0002114_abnormal_axial_skeleton0.91437915
106MP0000013_abnormal_adipose_tissue0.90979200
107MP0002060_abnormal_skin_morphology0.90829106
108MP0005666_abnormal_adipose_tissue0.90460785
109MP0001299_abnormal_eye_distance/0.90064192
110MP0000762_abnormal_tongue_morphology0.89201498
111MP0002092_abnormal_eye_morphology0.88868358
112MP0000428_abnormal_craniofacial_morphol0.88830707
113MP0000598_abnormal_liver_morphology0.88686939
114MP0002075_abnormal_coat/hair_pigmentati0.86275608
115MP0000750_abnormal_muscle_regeneration0.86013109
116MP0010368_abnormal_lymphatic_system0.84987725
117MP0004215_abnormal_myocardial_fiber0.83267535
118MP0000266_abnormal_heart_morphology0.82974822
119MP0008770_decreased_survivor_rate0.82753564
120MP0009053_abnormal_anal_canal0.81475678
121MP0001293_anophthalmia0.81059901
122MP0000858_altered_metastatic_potential0.80263204
123MP0000467_abnormal_esophagus_morphology0.78825848
124MP0003935_abnormal_craniofacial_develop0.78482762
125MP0003191_abnormal_cellular_cholesterol0.78356931
126MP0005083_abnormal_biliary_tract0.78235806
127MP0002429_abnormal_blood_cell0.77954385
128MP0003091_abnormal_cell_migration0.76862774
129MP0005384_cellular_phenotype0.76826032
130MP0002116_abnormal_craniofacial_bone0.74171536
131MP0002111_abnormal_tail_morphology0.72938050
132MP0000477_abnormal_intestine_morphology0.72150426
133MP0003937_abnormal_limbs/digits/tail_de0.71882921
134MP0002081_perinatal_lethality0.70891960
135MP0000049_abnormal_middle_ear0.70465054
136MP0003329_amyloid_beta_deposits0.69815825
137MP0000462_abnormal_digestive_system0.69526726
138MP0005621_abnormal_cell_physiology0.68546921
139MP0009703_decreased_birth_body0.67793938
140MP0000759_abnormal_skeletal_muscle0.66266288
141MP0009333_abnormal_splenocyte_physiolog0.65313703
142MP0002970_abnormal_white_adipose0.65152581
143MP0000609_abnormal_liver_physiology0.64652606
144MP0005319_abnormal_enzyme/_coenzyme0.63748027
145MP0008877_abnormal_DNA_methylation0.62243971
146MP0005385_cardiovascular_system_phenoty0.61637065
147MP0001544_abnormal_cardiovascular_syste0.61637065
148MP0002909_abnormal_adrenal_gland0.61540002
149MP0006054_spinal_hemorrhage0.61428675
150MP0004036_abnormal_muscle_relaxation0.61148662

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.77922825
2Colon cancer (HP:0003003)4.43364774
3Hyperacusis (HP:0010780)3.42015248
4Medulloblastoma (HP:0002885)3.41475324
5Adenoma sebaceum (HP:0009720)3.28332376
6Angiofibromas (HP:0010615)3.28332376
7Abnormality of the lower motor neuron (HP:0002366)3.26908954
8Abnormality of the astrocytes (HP:0100707)3.19391766
9Astrocytoma (HP:0009592)3.19391766
10Progressive muscle weakness (HP:0003323)3.18208252
11Aplastic anemia (HP:0001915)3.12934860
12Abnormality of cells of the erythroid lineage (HP:0012130)3.08853822
13Insomnia (HP:0100785)2.99333533
14Abnormal number of erythroid precursors (HP:0012131)2.97383075
15Premature rupture of membranes (HP:0001788)2.96544578
16Distal lower limb amyotrophy (HP:0008944)2.92617318
17Ulnar bowing (HP:0003031)2.84321105
18Agnosia (HP:0010524)2.82186729
19Myoglobinuria (HP:0002913)2.76785178
20Broad distal phalanx of finger (HP:0009836)2.71800730
21Basal cell carcinoma (HP:0002671)2.70772022
22Cholecystitis (HP:0001082)2.61403488
23Abnormal gallbladder physiology (HP:0012438)2.61403488
24Abnormality of the anterior horn cell (HP:0006802)2.61355415
25Degeneration of anterior horn cells (HP:0002398)2.61355415
26Annular pancreas (HP:0001734)2.59848250
27Rhabdomyosarcoma (HP:0002859)2.57926019
28Selective tooth agenesis (HP:0001592)2.54107989
29Multiple enchondromatosis (HP:0005701)2.52696303
30Cerebral hypomyelination (HP:0006808)2.51454577
31Spastic diplegia (HP:0001264)2.50298648
32Ragged-red muscle fibers (HP:0003200)2.48831228
33Long palpebral fissure (HP:0000637)2.47685894
34Centrally nucleated skeletal muscle fibers (HP:0003687)2.46979507
35Protrusio acetabuli (HP:0003179)2.45302026
36Birth length less than 3rd percentile (HP:0003561)2.42641880
37High pitched voice (HP:0001620)2.42385485
38Renal duplication (HP:0000075)2.41227733
39Increased connective tissue (HP:0009025)2.40530628
40Elfin facies (HP:0004428)2.40246228
41Increased nuchal translucency (HP:0010880)2.39004304
42Breast hypoplasia (HP:0003187)2.37088594
43Rhabdomyolysis (HP:0003201)2.35574764
44Lower limb amyotrophy (HP:0007210)2.33053043
45Oral leukoplakia (HP:0002745)2.32336498
46Glioma (HP:0009733)2.30591222
47Bowel diverticulosis (HP:0005222)2.28206707
48Neoplasm of striated muscle (HP:0009728)2.26006101
49Abnormality of the calcaneus (HP:0008364)2.25948932
50Amaurosis fugax (HP:0100576)2.24754832
51Overriding aorta (HP:0002623)2.22473408
52Late onset (HP:0003584)2.20445384
53Renovascular hypertension (HP:0100817)2.20176091
54Abnormality of the umbilical cord (HP:0010881)2.19308199
55Disproportionate tall stature (HP:0001519)2.19246841
56Proximal placement of thumb (HP:0009623)2.18987658
57Myopathic facies (HP:0002058)2.18428575
58Microretrognathia (HP:0000308)2.17931698
59Deviation of the thumb (HP:0009603)2.17495173
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16299477
61Limb-girdle muscle atrophy (HP:0003797)2.16147823
62Shallow orbits (HP:0000586)2.15470667
63Abnormality of glycolysis (HP:0004366)2.14731018
64Hand muscle atrophy (HP:0009130)2.14204250
65Broad face (HP:0000283)2.11604438
66Pointed chin (HP:0000307)2.10969756
67Neuroblastic tumors (HP:0004376)2.09334202
68Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.09334202
69Neuroblastoma (HP:0003006)2.09334202
70Primitive neuroectodermal tumor (HP:0030065)2.09334202
71Intestinal polyp (HP:0005266)2.08267023
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.06551359
73Thrombocytosis (HP:0001894)2.05428192
74Neoplasm of the oral cavity (HP:0100649)2.05039709
75Microvesicular hepatic steatosis (HP:0001414)2.04568699
76Back pain (HP:0003418)2.04441634
77Abnormality of the salivary glands (HP:0010286)2.04299557
78Biconcave vertebral bodies (HP:0004586)2.03711828
79Abnormality of the motor neurons (HP:0002450)2.02879219
80Abnormal neuron morphology (HP:0012757)2.02879219
81Cortical dysplasia (HP:0002539)2.01885138
82Spinal rigidity (HP:0003306)2.01132517
83Reticulocytopenia (HP:0001896)2.00936267
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00891949
85Abnormality of the fetal cardiovascular system (HP:0010948)2.00423069
86Abnormal umbilical cord blood vessels (HP:0011403)2.00423069
87Single umbilical artery (HP:0001195)2.00423069
88Intestinal polyposis (HP:0200008)2.00180208
89Turricephaly (HP:0000262)1.99002550
90Difficulty climbing stairs (HP:0003551)1.96597610
91Neoplasm of the rectum (HP:0100743)1.94314304
92Vertebral compression fractures (HP:0002953)1.93574619
93Truncus arteriosus (HP:0001660)1.91304857
94Short nail (HP:0001799)1.90762044
95Exercise-induced muscle cramps (HP:0003710)1.89970878
96Patellar dislocation (HP:0002999)1.87012770
97Dysmetric saccades (HP:0000641)1.86831402
98Distal upper limb amyotrophy (HP:0007149)1.86324477
99Upper limb amyotrophy (HP:0009129)1.86324477
100Abnormality of the phalanges of the hallux (HP:0010057)1.86218786
101Unsteady gait (HP:0002317)1.86050620
102Fibroma (HP:0010614)1.85444039
103High anterior hairline (HP:0009890)1.84383013
104Athetosis (HP:0002305)1.83525002
105Gout (HP:0001997)1.83004528
106Carpal bone hypoplasia (HP:0001498)1.82393632
107Chromsome breakage (HP:0040012)1.81180998
108Trigonocephaly (HP:0000243)1.80553778
109Hammertoe (HP:0001765)1.79993686
110Calcaneovalgus deformity (HP:0001848)1.79397412
111Neoplasm of the pancreas (HP:0002894)1.79396046
112Broad palm (HP:0001169)1.78434215
113Abnormality of reticulocytes (HP:0004312)1.78275704
114Insidious onset (HP:0003587)1.78071715
115Termporal pattern (HP:0011008)1.78071715
116Distal lower limb muscle weakness (HP:0009053)1.77801359
117Megaloblastic anemia (HP:0001889)1.75278468
118Abnormality of the tricuspid valve (HP:0001702)1.74994328
119Breech presentation (HP:0001623)1.74828110
120Septate vagina (HP:0001153)1.73866294
121Deep palmar crease (HP:0006191)1.73639621
122Absent epiphyses (HP:0010577)1.72535256
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72535256
124Achilles tendon contracture (HP:0001771)1.72460163
125Arnold-Chiari malformation (HP:0002308)1.71059360
126Abnormality of the distal phalanges of the toes (HP:0010182)1.70959132
127Megalocornea (HP:0000485)1.70636178
128Bladder diverticulum (HP:0000015)1.70179755
129Mildly elevated creatine phosphokinase (HP:0008180)1.70079330
130Shoulder girdle muscle weakness (HP:0003547)1.68861853
131Large hands (HP:0001176)1.68423074
132Neoplasm of the small intestine (HP:0100833)1.68297259
133Fibrous tissue neoplasm (HP:0012316)1.68272249
134Advanced eruption of teeth (HP:0006288)1.68209421
135Glossoptosis (HP:0000162)1.68186030
136Cafe-au-lait spot (HP:0000957)1.67951876
137Thin ribs (HP:0000883)1.67901664
138Duplication of thumb phalanx (HP:0009942)1.67790741
139Premature skin wrinkling (HP:0100678)1.67298492
140Macrocytic anemia (HP:0001972)1.67170938
141Biliary tract neoplasm (HP:0100574)1.66749396
142Trismus (HP:0000211)1.66637765
143Asymmetry of the thorax (HP:0001555)1.66491766
144Impaired pain sensation (HP:0007328)1.66048106
145Abnormality of pain sensation (HP:0010832)1.66048106
146Abnormality of the Achilles tendon (HP:0005109)1.65996087
147Flat acetabular roof (HP:0003180)1.65994132
148Vertebral arch anomaly (HP:0008438)1.65886984
149Stridor (HP:0010307)1.65825927
150Reticulocytosis (HP:0001923)1.65529137
151Neoplasm of the colon (HP:0100273)1.65030814
152Abnormal number of incisors (HP:0011064)1.64569189
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.64193114
154Hyperammonemia (HP:0001987)1.63994826
155Urethral obstruction (HP:0000796)1.63404397
156Pseudobulbar signs (HP:0002200)1.63248453
157Verrucae (HP:0200043)1.61550469
158Papilloma (HP:0012740)1.61550469
159Precocious puberty (HP:0000826)1.61035695
160Natal tooth (HP:0000695)1.60791175
161Orthostatic hypotension (HP:0001278)1.60448227
162Ankle contracture (HP:0006466)1.60333566
163Missing ribs (HP:0000921)1.60083071
164EMG: neuropathic changes (HP:0003445)1.59965564
165Exercise-induced myalgia (HP:0003738)1.59903056
166Abnormality of the diencephalon (HP:0010662)1.59004643
167Elbow flexion contracture (HP:0002987)1.58861887
168Slender long bone (HP:0003100)1.57344587
169Progressive external ophthalmoplegia (HP:0000590)1.57325961
170Spinal muscular atrophy (HP:0007269)1.57160467
171Insulin resistance (HP:0000855)1.56261855
172Abnormality of skeletal muscle fiber size (HP:0012084)1.56118532
173Entropion (HP:0000621)1.56101052
174Ventricular fibrillation (HP:0001663)1.55870780
175Overlapping toe (HP:0001845)1.55145172
176Cerebral aneurysm (HP:0004944)1.54603875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK197.93417170
2MAP3K105.28160390
3SMG14.07682971
4PKN22.90143124
5EEF2K2.85874452
6CDC72.82711380
7TRIB32.73272841
8BUB12.70930814
9NEK12.63753703
10WEE12.12444713
11SCYL22.03878482
12PRPF4B2.00386101
13MAP2K31.97436749
14NEK21.74804455
15IRAK31.74108208
16BCKDK1.66441581
17TSSK61.59063898
18FLT31.54802397
19SIK11.54038339
20TLK11.50314141
21TESK21.46981463
22ARAF1.44277378
23PASK1.36803236
24CDK41.31434579
25PDGFRA1.24890146
26TGFBR11.24608045
27VRK21.24307264
28LRRK21.21448928
29ALK1.21168621
30ACVR1B1.18662685
31BRSK11.17736448
32ERN11.17035480
33MAPKAPK31.16606318
34STK101.16542363
35PAK41.15460271
36MAP4K11.14720408
37FGFR41.13618123
38BRAF1.10272132
39MAP3K81.07680006
40RPS6KB21.07166884
41DAPK11.06687446
42TAOK11.05955060
43TTK1.04655140
44MAP2K61.00982708
45PTK21.00480800
46NTRK10.99551992
47CDK80.98707101
48BRSK20.95544325
49PLK10.94256334
50LIMK10.93036698
51CDK70.90389912
52EIF2AK10.86910137
53LMTK20.86579274
54MAP3K110.86398814
55MST1R0.83792145
56KDR0.83107063
57AURKA0.81962299
58RPS6KA40.81794850
59PIM20.81493493
60STK40.81395636
61TTN0.81191078
62CAMK1D0.78920911
63ATR0.78311159
64PRKD30.75100537
65PBK0.74415841
66CDK11A0.74246328
67CDK90.74210043
68TESK10.73434946
69CCNB10.72286428
70DYRK30.71045091
71LATS20.70349034
72PAK60.68091018
73PLK40.66167594
74AURKB0.65941806
75MAP3K90.65000297
76ILK0.64021762
77ZAP700.63334668
78PDK30.62729474
79PDK40.62729474
80CDK120.62723369
81MTOR0.62529241
82PAK20.61828339
83PTK60.61311171
84CDK20.60429199
85NME20.60372175
86KSR20.59619901
87BRD40.59220250
88RAF10.58466610
89PLK30.57532134
90CAMK1G0.57054346
91CHEK10.56251186
92PHKG10.54874213
93PHKG20.54874213
94GRK60.54000283
95TAOK20.53495283
96CLK10.53245354
97MARK20.52971218
98MET0.52304740
99CAMKK10.50746808
100BMX0.49297763
101AKT20.49074858
102DAPK30.48342439
103RIPK10.47632242
104MAP3K60.46774779
105DMPK0.44548666
106MAP2K40.42400372
107MAPK110.41346042
108RPS6KA20.40659739
109TIE10.39395427
110MINK10.37851300
111PAK10.37629067
112PRKD20.37458484
113SRPK10.37011476
114BTK0.36449403
115MAP2K70.36380397
116PDPK10.36277805
117ERBB40.36274867
118UHMK10.36227697
119CHEK20.36031078
120CDK60.32387086
121MAP3K70.31462055
122CDK150.31338634
123MAPK120.31245957
124PRKCI0.30909072
125CSNK2A20.30435811
126CSNK1E0.29979199
127MAPK90.28451675
128CDK180.28029546
129KSR10.27918905
130EPHA20.26864797
131ICK0.26377870
132CDK140.24833329
133CDK10.24377108
134ATM0.24173388
135CSF1R0.23919441
136FGFR10.22581412

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.97501171
2Mismatch repair_Homo sapiens_hsa034304.09194598
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.24276454
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.17559430
5Base excision repair_Homo sapiens_hsa034102.89777903
6One carbon pool by folate_Homo sapiens_hsa006702.77429639
7RNA transport_Homo sapiens_hsa030132.74783013
8Spliceosome_Homo sapiens_hsa030402.73647750
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70116794
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63498152
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.52083592
12Ribosome_Homo sapiens_hsa030102.49735929
13Biosynthesis of amino acids_Homo sapiens_hsa012302.42557974
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13609275
15Carbon metabolism_Homo sapiens_hsa012001.98656114
16Cell cycle_Homo sapiens_hsa041101.90436116
17Nucleotide excision repair_Homo sapiens_hsa034201.88234549
18Sulfur relay system_Homo sapiens_hsa041221.76403998
19Pyrimidine metabolism_Homo sapiens_hsa002401.73082690
20Homologous recombination_Homo sapiens_hsa034401.70445435
21Proteasome_Homo sapiens_hsa030501.59119561
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58122846
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.57255559
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46677294
25RNA polymerase_Homo sapiens_hsa030201.37791745
26Renin-angiotensin system_Homo sapiens_hsa046141.37061344
27mRNA surveillance pathway_Homo sapiens_hsa030151.35249347
28Nitrogen metabolism_Homo sapiens_hsa009101.27429381
29Selenocompound metabolism_Homo sapiens_hsa004501.27157633
30Vitamin B6 metabolism_Homo sapiens_hsa007501.22026598
31Pentose phosphate pathway_Homo sapiens_hsa000301.20489956
32RNA degradation_Homo sapiens_hsa030181.11978999
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10215275
34Pancreatic cancer_Homo sapiens_hsa052121.08224101
35Oocyte meiosis_Homo sapiens_hsa041141.05767497
36Pyruvate metabolism_Homo sapiens_hsa006201.04889530
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.02839936
38Glioma_Homo sapiens_hsa052140.99619048
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98364033
40Adherens junction_Homo sapiens_hsa045200.98066933
41Vibrio cholerae infection_Homo sapiens_hsa051100.97674093
42Fructose and mannose metabolism_Homo sapiens_hsa000510.96512365
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94031526
44Thyroid cancer_Homo sapiens_hsa052160.92144545
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91469886
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89520317
47Folate biosynthesis_Homo sapiens_hsa007900.87120611
48MicroRNAs in cancer_Homo sapiens_hsa052060.86787340
49Prion diseases_Homo sapiens_hsa050200.85601956
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83486227
51p53 signaling pathway_Homo sapiens_hsa041150.83481168
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83113852
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82784148
54Hippo signaling pathway_Homo sapiens_hsa043900.80925731
55Galactose metabolism_Homo sapiens_hsa000520.80761617
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80273025
57Lysine degradation_Homo sapiens_hsa003100.77611272
58Purine metabolism_Homo sapiens_hsa002300.77295836
59Small cell lung cancer_Homo sapiens_hsa052220.76563511
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.76204666
61ErbB signaling pathway_Homo sapiens_hsa040120.73932882
62Arginine biosynthesis_Homo sapiens_hsa002200.72270858
63Fatty acid degradation_Homo sapiens_hsa000710.71866941
64Focal adhesion_Homo sapiens_hsa045100.68085834
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67827840
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67353017
67Alcoholism_Homo sapiens_hsa050340.66300574
68Synaptic vesicle cycle_Homo sapiens_hsa047210.66202468
69Proteoglycans in cancer_Homo sapiens_hsa052050.64493708
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63443842
71Epstein-Barr virus infection_Homo sapiens_hsa051690.63255686
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63166211
73HTLV-I infection_Homo sapiens_hsa051660.62193276
74Prostate cancer_Homo sapiens_hsa052150.61331940
75Phenylalanine metabolism_Homo sapiens_hsa003600.60925787
76Glucagon signaling pathway_Homo sapiens_hsa049220.59373260
77Tight junction_Homo sapiens_hsa045300.59301164
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59246642
79mTOR signaling pathway_Homo sapiens_hsa041500.57140226
80beta-Alanine metabolism_Homo sapiens_hsa004100.54932502
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54137723
82Renal cell carcinoma_Homo sapiens_hsa052110.53268534
83Viral carcinogenesis_Homo sapiens_hsa052030.52899069
84Basal cell carcinoma_Homo sapiens_hsa052170.52879964
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51101696
86Bladder cancer_Homo sapiens_hsa052190.50819224
87Apoptosis_Homo sapiens_hsa042100.48816556
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.48753947
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48570105
90Antigen processing and presentation_Homo sapiens_hsa046120.47782924
91Wnt signaling pathway_Homo sapiens_hsa043100.47459132
92N-Glycan biosynthesis_Homo sapiens_hsa005100.47102266
93HIF-1 signaling pathway_Homo sapiens_hsa040660.46602840
94Fanconi anemia pathway_Homo sapiens_hsa034600.45960282
95Acute myeloid leukemia_Homo sapiens_hsa052210.45820768
96Melanoma_Homo sapiens_hsa052180.44994941
97Chronic myeloid leukemia_Homo sapiens_hsa052200.44871757
98Non-homologous end-joining_Homo sapiens_hsa034500.44540400
99Melanogenesis_Homo sapiens_hsa049160.44250808
100Dilated cardiomyopathy_Homo sapiens_hsa054140.42094013
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40009782
102Propanoate metabolism_Homo sapiens_hsa006400.38488393
103Non-small cell lung cancer_Homo sapiens_hsa052230.38071315
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36919674
105Insulin signaling pathway_Homo sapiens_hsa049100.36817800
106VEGF signaling pathway_Homo sapiens_hsa043700.35913758
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35877339
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35355768
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34794502
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34572460
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34273249
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33988463
113Arginine and proline metabolism_Homo sapiens_hsa003300.32877503
114Colorectal cancer_Homo sapiens_hsa052100.31328890
115Notch signaling pathway_Homo sapiens_hsa043300.30162359
116Legionellosis_Homo sapiens_hsa051340.28981999
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28699854
118AMPK signaling pathway_Homo sapiens_hsa041520.28293732
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26777626
120Herpes simplex infection_Homo sapiens_hsa051680.24176482
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23042926
122African trypanosomiasis_Homo sapiens_hsa051430.22362828
123Cardiac muscle contraction_Homo sapiens_hsa042600.20511949
124Shigellosis_Homo sapiens_hsa051310.19903835
125Bile secretion_Homo sapiens_hsa049760.19395576
126Primary immunodeficiency_Homo sapiens_hsa053400.18544549
127Glutathione metabolism_Homo sapiens_hsa004800.17432736
128Insulin resistance_Homo sapiens_hsa049310.17122858
129Fatty acid metabolism_Homo sapiens_hsa012120.15238613
130Endometrial cancer_Homo sapiens_hsa052130.14978841
131Fat digestion and absorption_Homo sapiens_hsa049750.14958227
132Tryptophan metabolism_Homo sapiens_hsa003800.13862927

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