PPP3R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)9.90191914
2cell wall macromolecule catabolic process (GO:0016998)9.90191914
3epithelial cilium movement (GO:0003351)9.83111124
4spermatid development (GO:0007286)9.40580961
5motile cilium assembly (GO:0044458)9.37449527
6male meiosis (GO:0007140)9.01891723
7reproduction (GO:0000003)8.85726208
8synaptonemal complex organization (GO:0070193)8.44210455
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.43395426
10cilium movement (GO:0003341)8.42858173
11synaptonemal complex assembly (GO:0007130)8.10761421
12regulation of cilium movement (GO:0003352)7.97354524
13single fertilization (GO:0007338)7.30879138
14sperm capacitation (GO:0048240)6.66859853
15DNA methylation involved in gamete generation (GO:0043046)6.62556243
16negative regulation of inclusion body assembly (GO:0090084)6.59377690
17fertilization (GO:0009566)6.39204706
18spermatogenesis (GO:0007283)6.25766915
19male gamete generation (GO:0048232)6.23553815
20male meiosis I (GO:0007141)6.09660373
21protein targeting to Golgi (GO:0000042)6.04487475
22establishment of protein localization to Golgi (GO:0072600)5.89931782
23gamete generation (GO:0007276)5.72820610
24leukotriene biosynthetic process (GO:0019370)5.72775390
25chromosome organization involved in meiosis (GO:0070192)5.69577618
26adaptation of signaling pathway (GO:0023058)5.69271370
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.56430013
28microtubule depolymerization (GO:0007019)5.44641120
29organic cation transport (GO:0015695)5.44558637
30germ cell development (GO:0007281)5.42413410
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.37564263
32ventricular system development (GO:0021591)5.36333055
33regulation of inclusion body assembly (GO:0090083)5.33085239
34seminiferous tubule development (GO:0072520)5.28541716
35meiotic nuclear division (GO:0007126)5.24850547
36meiosis I (GO:0007127)4.93044668
37calcium ion-dependent exocytosis (GO:0017156)4.88066942
38cell recognition (GO:0008037)4.84311496
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.76691993
40regulation of microtubule-based movement (GO:0060632)4.73734528
41microtubule severing (GO:0051013)4.64996991
42RNA destabilization (GO:0050779)4.53743010
43meiotic cell cycle (GO:0051321)4.53404653
44multicellular organismal reproductive process (GO:0048609)4.49253322
45protein localization to cilium (GO:0061512)4.43135610
46left/right pattern formation (GO:0060972)4.31635036
47protein localization to Golgi apparatus (GO:0034067)4.25754365
48alanine transport (GO:0032328)4.23780409
49serotonin metabolic process (GO:0042428)4.13825667
50cysteine metabolic process (GO:0006534)4.05078137
51genitalia morphogenesis (GO:0035112)4.02625018
52primary amino compound metabolic process (GO:1901160)4.00847802
53monoubiquitinated protein deubiquitination (GO:0035520)3.96459884
54response to acidic pH (GO:0010447)3.94566162
55chaperone-mediated protein complex assembly (GO:0051131)3.93652358
56glycerol ether metabolic process (GO:0006662)3.87749838
57spermatid nucleus differentiation (GO:0007289)3.85795289
58gene silencing by RNA (GO:0031047)3.80656468
59chromosome condensation (GO:0030261)3.78520073
60phosphatidylethanolamine metabolic process (GO:0046337)3.73280833
61leukotriene metabolic process (GO:0006691)3.71156521
62DNA packaging (GO:0006323)3.67111989
63phosphatidylethanolamine biosynthetic process (GO:0006646)3.66803687
64intraciliary transport (GO:0042073)3.66188359
65multicellular organismal development (GO:0007275)3.65751000
66protein polyglutamylation (GO:0018095)3.64176846
67somite rostral/caudal axis specification (GO:0032525)3.59760836
68ether metabolic process (GO:0018904)3.58246161
69regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.57270489
70positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.57270489
71synapsis (GO:0007129)3.45764903
72axoneme assembly (GO:0035082)3.40218827
73negative regulation of organelle assembly (GO:1902116)3.39797166
74meiotic cell cycle process (GO:1903046)3.38749784
75response to pheromone (GO:0019236)3.37330519
76lactate metabolic process (GO:0006089)3.36201681
77nephron tubule morphogenesis (GO:0072078)3.35595640
78nephron epithelium morphogenesis (GO:0072088)3.35595640
79regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.33314074
80positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.33314074
81behavioral response to nicotine (GO:0035095)3.32153572
82carnitine transport (GO:0015879)3.30954771
83amino-acid betaine transport (GO:0015838)3.30954771
84carnitine transmembrane transport (GO:1902603)3.28044929
85tachykinin receptor signaling pathway (GO:0007217)3.27680514
86microtubule-based movement (GO:0007018)3.24501758
87regulation of spindle checkpoint (GO:0090231)3.19046376
88alditol metabolic process (GO:0019400)3.18471745
89glutamate receptor signaling pathway (GO:0007215)3.12496319
90regulation of platelet aggregation (GO:0090330)3.11349207
91protein refolding (GO:0042026)3.10879900
92nucleoside diphosphate phosphorylation (GO:0006165)3.08847847
93negative regulation of homotypic cell-cell adhesion (GO:0034111)3.08767134
94phosphorelay signal transduction system (GO:0000160)3.06925418
95polyol catabolic process (GO:0046174)3.06855515
96mitotic sister chromatid cohesion (GO:0007064)3.06691517
97detection of light stimulus involved in visual perception (GO:0050908)3.04991973
98detection of light stimulus involved in sensory perception (GO:0050962)3.04991973
99negative regulation of cAMP-mediated signaling (GO:0043951)3.04821178
100cilium organization (GO:0044782)3.03704737
101regulation of centriole replication (GO:0046599)3.00493050
102relaxation of smooth muscle (GO:0044557)3.00446555
103smooth muscle tissue development (GO:0048745)3.00220293
104neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.98871128
105regulation of meiosis I (GO:0060631)2.97240389
106protein K11-linked deubiquitination (GO:0035871)2.94649319
107ionotropic glutamate receptor signaling pathway (GO:0035235)2.92427499
108GTP biosynthetic process (GO:0006183)2.91519733
109cilium morphogenesis (GO:0060271)2.91226890
110sequestering of actin monomers (GO:0042989)2.90226688
111rRNA methylation (GO:0031167)2.88633416
112negative regulation of neurotransmitter transport (GO:0051589)2.88191759
113regulation of phosphoprotein phosphatase activity (GO:0043666)2.87138391
114glycolytic process (GO:0006096)2.87029040
115cilium assembly (GO:0042384)2.86942433
116cellular component assembly involved in morphogenesis (GO:0010927)2.85235935
117glutathione metabolic process (GO:0006749)2.83007696
118nuclear pore complex assembly (GO:0051292)2.82962002
119positive regulation of gastrulation (GO:2000543)2.82728331
120regulation of protein polyubiquitination (GO:1902914)2.81122585
121regulation of transcription involved in cell fate commitment (GO:0060850)2.79940366
122gene silencing (GO:0016458)2.78927477
123glycerol metabolic process (GO:0006071)2.78844186
124positive regulation of cAMP-mediated signaling (GO:0043950)2.78287394
125single strand break repair (GO:0000012)2.76429640
126nucleus organization (GO:0006997)2.75764141
127microtubule polymerization or depolymerization (GO:0031109)2.75746954
128cardiac muscle adaptation (GO:0014887)2.72819908
129cardiac muscle hypertrophy in response to stress (GO:0014898)2.72819908
130muscle hypertrophy in response to stress (GO:0003299)2.72819908
131fatty acid derivative biosynthetic process (GO:1901570)2.72290655
132icosanoid biosynthetic process (GO:0046456)2.72290655
133regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71732720
134renal tubule morphogenesis (GO:0061333)2.71449265
135L-serine transport (GO:0015825)2.70108527
136intra-Golgi vesicle-mediated transport (GO:0006891)2.69300678
137regulation of feeding behavior (GO:0060259)2.67514316
138negative regulation of platelet activation (GO:0010544)2.66083254
139cAMP catabolic process (GO:0006198)2.62304222
140positive regulation of mRNA catabolic process (GO:0061014)2.62167822
141peptide catabolic process (GO:0043171)2.61151451
142sulfation (GO:0051923)2.61028978
143negative regulation of heart rate (GO:0010459)2.60615172
144glutathione biosynthetic process (GO:0006750)2.60294704
145cGMP-mediated signaling (GO:0019934)2.59681898
146UTP biosynthetic process (GO:0006228)2.59681049
147peptidyl-glutamic acid modification (GO:0018200)2.57849455
148interferon-gamma secretion (GO:0072643)2.54313916
149centriole assembly (GO:0098534)2.53410080
150centriole replication (GO:0007099)2.52633032
151cilium or flagellum-dependent cell motility (GO:0001539)13.4495692
152fusion of sperm to egg plasma membrane (GO:0007342)13.1738898
153sperm motility (GO:0030317)12.7290780
154acrosome assembly (GO:0001675)11.6410580
155sperm-egg recognition (GO:0035036)11.1820778
156acrosome reaction (GO:0007340)10.8014399
157axonemal dynein complex assembly (GO:0070286)10.6962444
158multicellular organism reproduction (GO:0032504)10.6853559
159binding of sperm to zona pellucida (GO:0007339)10.4546824
160piRNA metabolic process (GO:0034587)10.3744032
161plasma membrane fusion (GO:0045026)10.0264631
162cell-cell recognition (GO:0009988)10.0008080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70854054
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66448269
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36654612
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.06362309
5GBX2_23144817_ChIP-Seq_PC3_Human2.94680803
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68623926
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64575697
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52534686
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49703226
10ZNF274_21170338_ChIP-Seq_K562_Hela2.30747447
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26162757
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.24080689
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19433542
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16195893
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10176360
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09407546
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2290992
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99100927
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.98245642
20VDR_22108803_ChIP-Seq_LS180_Human1.94680705
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89489302
22TAF15_26573619_Chip-Seq_HEK293_Human1.89045706
23FUS_26573619_Chip-Seq_HEK293_Human1.84150478
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82221851
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.78809571
26IGF1R_20145208_ChIP-Seq_DFB_Human1.78648095
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75470897
28P300_19829295_ChIP-Seq_ESCs_Human1.67886767
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64662324
30SMAD4_21799915_ChIP-Seq_A2780_Human1.62652060
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62431598
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61322017
33AR_21572438_ChIP-Seq_LNCaP_Human1.57313911
34STAT1_17558387_ChIP-Seq_HELA_Human1.57144372
35ER_23166858_ChIP-Seq_MCF-7_Human1.54868872
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53423998
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52968244
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.49166060
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48943112
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48808476
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.47366737
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47064516
43DROSHA_22980978_ChIP-Seq_HELA_Human1.46573291
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.46298889
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45318715
46STAT3_23295773_ChIP-Seq_U87_Human1.43818419
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43814283
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.42172547
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41683931
50SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40146563
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39702660
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38557194
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37935810
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37159368
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.36913240
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.36613147
57CBP_20019798_ChIP-Seq_JUKART_Human1.36295463
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36295463
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.36210070
60KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36041096
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35274550
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.35194590
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34953085
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.33971161
65KDM2B_26808549_Chip-Seq_REH_Human1.31677639
66RUNX2_22187159_ChIP-Seq_PCA_Human1.31028974
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28859303
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.28073931
69AR_25329375_ChIP-Seq_VCAP_Human1.27392105
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27204341
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.25574211
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24562203
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23227088
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23202640
75* REST_21632747_ChIP-Seq_MESCs_Mouse1.21978470
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21787244
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21597736
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21569185
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20146253
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17809214
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17380344
82FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17263488
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17177828
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.17000611
85TBL1_22424771_ChIP-Seq_293T_Human1.16495783
86SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15618907
87P53_21459846_ChIP-Seq_SAOS-2_Human1.15582209
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.15502032
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.12761334
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.12628930
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11685740
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11685740
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11170034
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11074082
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10638698
96SCL_19346495_ChIP-Seq_HPC-7_Human1.10335452
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09579133
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08926107
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08594307
100NANOG_19829295_ChIP-Seq_ESCs_Human1.08240908
101SOX2_19829295_ChIP-Seq_ESCs_Human1.08240908
102SMAD3_21741376_ChIP-Seq_ESCs_Human1.07929590
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07542925
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07474293
105CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07085102
106AHR_22903824_ChIP-Seq_MCF-7_Human1.06910708
107RXR_22108803_ChIP-Seq_LS180_Human1.06139341
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.05894328
109GF1_26923725_Chip-Seq_HPCs_Mouse1.05703236
110TP53_18474530_ChIP-ChIP_U2OS_Human1.05426480
111SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04792901
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04438149
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04125859
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03697122
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.03379316
116TCF4_23295773_ChIP-Seq_U87_Human1.02992590
117MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02661156
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01804785
119TCF4_18268006_ChIP-ChIP_LS174T_Human1.01347007
120RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01240451
121EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01240451
122RNF2_27304074_Chip-Seq_NSC_Mouse1.01210007
123ETV1_20927104_ChIP-Seq_GIST48_Human1.00803436
124SMAD4_21741376_ChIP-Seq_HESCs_Human1.00554244
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00152584
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99910348
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99320322
128ERG_20517297_ChIP-Seq_VCAP_Human0.99128915
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98639955
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98411634
131TCF4_22108803_ChIP-Seq_LS180_Human0.98289491
132OCT4_18555785_Chip-Seq_ESCs_Mouse0.98220038
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97439255
134MYC_19829295_ChIP-Seq_ESCs_Human0.97341604
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96939430
136BCAT_22108803_ChIP-Seq_LS180_Human0.96479565
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96049792
138NFYB_21822215_ChIP-Seq_K562_Human0.95901685
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94753201
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.94546085
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94193847
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.93974432
143P53_22387025_ChIP-Seq_ESCs_Mouse0.93916403
144SOX2_21211035_ChIP-Seq_LN229_Gbm0.92786843
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92661623
146RUNX_20019798_ChIP-Seq_JUKART_Human0.92057237
147SPI1_26923725_Chip-Seq_HPCs_Mouse0.92047321
148OCT1_27270436_Chip-Seq_PROSTATE_Human0.92036013
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.91757002
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91591760
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.91590799
152* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91283730
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90904192
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90899173
155* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90890685
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90152725
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89732627
158P300_18555785_Chip-Seq_ESCs_Mouse0.89592730
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88790427
160KLF4_18555785_Chip-Seq_ESCs_Mouse0.87958376
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87526179
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87512867
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.85956583
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85887566
165SOX2_21211035_ChIP-Seq_LN229_Human0.85442048
166ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85091919
167LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84631673
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84613999
169CMYC_18555785_Chip-Seq_ESCs_Mouse0.84075540
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83748543
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83607400
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.83390857
173SMAD4_21741376_ChIP-Seq_EPCs_Human0.81458669
174STAT3_18555785_Chip-Seq_ESCs_Mouse0.81364799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04581787
2MP0001929_abnormal_gametogenesis5.60710855
3MP0008877_abnormal_DNA_methylation5.30089832
4MP0002210_abnormal_sex_determination3.80427824
5MP0002163_abnormal_gland_morphology3.53563947
6MP0005379_endocrine/exocrine_gland_phen3.33669051
7MP0002161_abnormal_fertility/fecundity3.27262519
8MP0001145_abnormal_male_reproductive3.19469020
9MP0009697_abnormal_copulation2.93971955
10MP0002653_abnormal_ependyma_morphology2.84254205
11MP0002138_abnormal_hepatobiliary_system2.82269759
12MP0000653_abnormal_sex_gland2.76268233
13MP0003183_abnormal_peptide_metabolism2.74800032
14MP0003880_abnormal_central_pattern2.16706140
15MP0001348_abnormal_lacrimal_gland2.11988586
16MP0010386_abnormal_urinary_bladder2.09901992
17MP0001879_abnormal_lymphatic_vessel2.05812724
18MP0001486_abnormal_startle_reflex2.02015789
19MP0010368_abnormal_lymphatic_system2.01223584
20MP0005410_abnormal_fertilization15.6105444
21MP0002160_abnormal_reproductive_system1.97434446
22MP0005670_abnormal_white_adipose1.97265602
23MP0002277_abnormal_respiratory_mucosa1.87455366
24MP0009745_abnormal_behavioral_response1.84639088
25MP0002876_abnormal_thyroid_physiology1.83392126
26MP0005623_abnormal_meninges_morphology1.83354993
27MP0003315_abnormal_perineum_morphology1.78601095
28MP0008057_abnormal_DNA_replication1.69212311
29MP0003646_muscle_fatigue1.50902895
30MP0003787_abnormal_imprinting1.49967114
31MP0001501_abnormal_sleep_pattern1.48110002
32MP0003635_abnormal_synaptic_transmissio1.46080586
33MP0002572_abnormal_emotion/affect_behav1.44770828
34MP0002089_abnormal_postnatal_growth/wei1.44313334
35MP0005645_abnormal_hypothalamus_physiol1.43922900
36MP0008872_abnormal_physiological_respon1.41290337
37MP0000230_abnormal_systemic_arterial1.40435477
38MP0001485_abnormal_pinna_reflex1.37725326
39MP0002272_abnormal_nervous_system1.36922987
40MP0004084_abnormal_cardiac_muscle1.34978548
41MP0002282_abnormal_trachea_morphology1.32491710
42MP0002064_seizures1.29906108
43MP0002693_abnormal_pancreas_physiology1.27010696
44MP0005171_absent_coat_pigmentation1.26464958
45MP0008058_abnormal_DNA_repair1.20722786
46MP0001502_abnormal_circadian_rhythm1.20257302
47MP0001756_abnormal_urination1.19833395
48MP0001905_abnormal_dopamine_level1.19090042
49MP0004142_abnormal_muscle_tone1.17460244
50MP0005647_abnormal_sex_gland1.15714089
51MP0001963_abnormal_hearing_physiology1.15530890
52MP0005187_abnormal_penis_morphology1.13676662
53MP0001919_abnormal_reproductive_system1.11239148
54MP0004233_abnormal_muscle_weight1.10499628
55MP0001984_abnormal_olfaction1.09425184
56MP0002067_abnormal_sensory_capabilities1.06650319
57MP0008569_lethality_at_weaning1.04736997
58MP0009046_muscle_twitch1.03754543
59MP0010094_abnormal_chromosome_stability1.03487191
60MP0001346_abnormal_lacrimal_gland1.03472352
61MP0000026_abnormal_inner_ear1.02350132
62MP0008995_early_reproductive_senescence1.02194900
63MP0005595_abnormal_vascular_smooth1.01940191
64MP0002735_abnormal_chemical_nociception1.01296054
65MP0003011_delayed_dark_adaptation1.01210336
66MP0002063_abnormal_learning/memory/cond1.00695508
67MP0004924_abnormal_behavior1.00093787
68MP0005386_behavior/neurological_phenoty1.00093787
69MP0005389_reproductive_system_phenotype0.98493149
70MP0001765_abnormal_ion_homeostasis0.97899625
71MP0002009_preneoplasia0.97576888
72MP0000538_abnormal_urinary_bladder0.94861297
73MP0003890_abnormal_embryonic-extraembry0.94665769
74MP0005167_abnormal_blood-brain_barrier0.94545113
75MP0001944_abnormal_pancreas_morphology0.92647074
76MP0000470_abnormal_stomach_morphology0.90889879
77MP0004885_abnormal_endolymph0.89647003
78MP0002557_abnormal_social/conspecific_i0.88484449
79MP0004883_abnormal_blood_vessel0.87509272
80MP0003959_abnormal_lean_body0.86895752
81MP0004147_increased_porphyrin_level0.86839692
82MP0010329_abnormal_lipoprotein_level0.85436447
83MP0000249_abnormal_blood_vessel0.84292013
84MP0000631_abnormal_neuroendocrine_gland0.82928753
85MP0000569_abnormal_digit_pigmentation0.80020238
86MP0003786_premature_aging0.79980802
87MP0008007_abnormal_cellular_replicative0.79426960
88MP0002733_abnormal_thermal_nociception0.78363903
89MP0004085_abnormal_heartbeat0.77721830
90MP0001968_abnormal_touch/_nociception0.76559965
91MP0002882_abnormal_neuron_morphology0.74052558
92MP0003632_abnormal_nervous_system0.70518510
93MP0000613_abnormal_salivary_gland0.70271085
94MP0000778_abnormal_nervous_system0.70132409
95MP0004270_analgesia0.69244547
96MP0000537_abnormal_urethra_morphology0.68755383
97MP0002234_abnormal_pharynx_morphology0.62784996
98MP0000358_abnormal_cell_content/0.61783091
99MP0005397_hematopoietic_system_phenotyp0.60336430
100MP0001545_abnormal_hematopoietic_system0.60336430
101MP0003115_abnormal_respiratory_system0.59117714
102MP0005377_hearing/vestibular/ear_phenot0.58435569
103MP0003878_abnormal_ear_physiology0.58435569
104MP0003950_abnormal_plasma_membrane0.56123381
105MP0003329_amyloid_beta_deposits0.55299254
106MP0004134_abnormal_chest_morphology0.55199654
107MP0009278_abnormal_bone_marrow0.53299612
108MP0004808_abnormal_hematopoietic_stem0.51531788
109MP0005636_abnormal_mineral_homeostasis0.49357927
110MP0003111_abnormal_nucleus_morphology0.49046723
111MP0003699_abnormal_female_reproductive0.48123881
112MP0005666_abnormal_adipose_tissue0.44796923
113MP0002928_abnormal_bile_duct0.43882243
114MP0004036_abnormal_muscle_relaxation0.43293065
115MP0010307_abnormal_tumor_latency0.42698345
116MP0001324_abnormal_eye_pigmentation0.42172967
117MP0005253_abnormal_eye_physiology0.41124814
118MP0005551_abnormal_eye_electrophysiolog0.40174380
119MP0001293_anophthalmia0.40010442
120MP0001730_embryonic_growth_arrest0.39132047
121MP0001119_abnormal_female_reproductive0.37839180
122MP0006036_abnormal_mitochondrial_physio0.36794374
123MP0005391_vision/eye_phenotype0.33897042
124MP0002269_muscular_atrophy0.33792078
125MP0001727_abnormal_embryo_implantation0.32978225
126MP0001764_abnormal_homeostasis0.31375283
127MP0004019_abnormal_vitamin_homeostasis0.30827213
128MP0002971_abnormal_brown_adipose0.28560119
129MP0004811_abnormal_neuron_physiology0.28422157
130MP0003861_abnormal_nervous_system0.28216501
131MP0002152_abnormal_brain_morphology0.26775138
132MP0003077_abnormal_cell_cycle0.26437923
133MP0000751_myopathy0.25715503
134MP0009115_abnormal_fat_cell0.25488972
135MP0000604_amyloidosis0.25383070
136MP0000313_abnormal_cell_death0.25039321
137MP0003633_abnormal_nervous_system0.24410408
138MP0003879_abnormal_hair_cell0.24057798
139MP0008961_abnormal_basal_metabolism0.23981395
140MP0004133_heterotaxia0.23851346
141MP0000534_abnormal_ureter_morphology0.23666530
142MP0001661_extended_life_span0.23017108
143MP0003045_fibrosis0.22642753
144MP0003631_nervous_system_phenotype0.21583256
145MP0002092_abnormal_eye_morphology0.20375113
146MP0002084_abnormal_developmental_patter0.20227872
147MP0006035_abnormal_mitochondrial_morpho0.20063919
148MP0003942_abnormal_urinary_system0.19930214
149MP0006072_abnormal_retinal_apoptosis0.19673551
150MP0002736_abnormal_nociception_after0.19068346
151MP0001851_eye_inflammation0.17702272
152MP0002169_no_abnormal_phenotype0.17642373
153MP0000427_abnormal_hair_cycle0.17465397
154MP0002873_normal_phenotype0.17415549
155MP0002229_neurodegeneration0.16818209
156MP0002102_abnormal_ear_morphology0.16317578
157MP0003948_abnormal_gas_homeostasis0.16050954
158MP0004043_abnormal_pH_regulation0.15498558
159MP0005423_abnormal_somatic_nervous0.15438816
160MP0001440_abnormal_grooming_behavior0.15351442
161MP0001672_abnormal_embryogenesis/_devel0.13824095
162MP0005380_embryogenesis_phenotype0.13824095
163MP0003936_abnormal_reproductive_system0.13813327
164MP0002108_abnormal_muscle_morphology0.13763216
165MP0001697_abnormal_embryo_size0.13701293
166MP0004742_abnormal_vestibular_system0.13448381
167MP0000001_mammalian_phenotype0.13302006
168MP0005195_abnormal_posterior_eye0.12930971

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.51284301
2Abnormal respiratory motile cilium morphology (HP:0005938)8.99344130
3Abnormal respiratory epithelium morphology (HP:0012253)8.99344130
4Rhinitis (HP:0012384)7.96836878
5Abnormal ciliary motility (HP:0012262)7.57856234
6Chronic bronchitis (HP:0004469)7.49441701
7Infertility (HP:0000789)6.56127863
8Nasal polyposis (HP:0100582)6.38354239
9Abnormality of the nasal mucosa (HP:0000433)5.23944563
10Bronchiectasis (HP:0002110)4.56860894
11Nephronophthisis (HP:0000090)4.52144382
12Bronchitis (HP:0012387)4.50439468
13Genetic anticipation (HP:0003743)3.97901628
14Chronic hepatic failure (HP:0100626)3.88078671
15Progressive cerebellar ataxia (HP:0002073)3.81563743
16Bony spicule pigmentary retinopathy (HP:0007737)3.73367524
17Male infertility (HP:0003251)3.55996214
18Nonprogressive disorder (HP:0003680)3.50199184
19Abnormality of the lower motor neuron (HP:0002366)3.49316681
20Attenuation of retinal blood vessels (HP:0007843)3.48914287
21Abnormality of the renal medulla (HP:0100957)3.43629695
22Abnormal rod and cone electroretinograms (HP:0008323)3.37254741
23Recurrent sinusitis (HP:0011108)3.36316273
24Recurrent otitis media (HP:0000403)3.30440645
25Abnormality of binocular vision (HP:0011514)3.15213852
26Diplopia (HP:0000651)3.15213852
27Thickened calvaria (HP:0002684)3.12653573
28Abnormality of macular pigmentation (HP:0008002)3.08401905
29Gonadotropin excess (HP:0000837)3.07363611
30Progressive inability to walk (HP:0002505)3.02773376
31Abnormal spermatogenesis (HP:0008669)3.01965061
32Hyperkalemia (HP:0002153)3.00013429
33Tubulointerstitial nephritis (HP:0001970)2.94914498
34Inability to walk (HP:0002540)2.89694026
35Flat acetabular roof (HP:0003180)2.84719544
36Carpal bone hypoplasia (HP:0001498)2.84433647
37Abnormality of the lumbar spine (HP:0100712)2.83595430
38Dyskinesia (HP:0100660)2.79862505
39Broad ribs (HP:0000885)2.77840185
40Intestinal atresia (HP:0011100)2.77604139
41Amyotrophic lateral sclerosis (HP:0007354)2.76014252
42Diastasis recti (HP:0001540)2.75915010
43Abnormality of the sella turcica (HP:0002679)2.74743598
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.70661679
45Hypoplasia of the fovea (HP:0007750)2.70661679
46Postural instability (HP:0002172)2.69468350
47Severe visual impairment (HP:0001141)2.67248098
48Abnormality of midbrain morphology (HP:0002418)2.66573899
49Molar tooth sign on MRI (HP:0002419)2.66573899
50Tubular atrophy (HP:0000092)2.62359930
51Drooling (HP:0002307)2.53256124
52Tubulointerstitial abnormality (HP:0001969)2.51614077
53Vertebral arch anomaly (HP:0008438)2.51129114
54Recurrent bronchitis (HP:0002837)2.51104647
55Congenital stationary night blindness (HP:0007642)2.50338862
56Fibular hypoplasia (HP:0003038)2.49871739
57Medial flaring of the eyebrow (HP:0010747)2.48584411
58Thoracic kyphosis (HP:0002942)2.46958642
59Focal motor seizures (HP:0011153)2.44263187
60Excessive salivation (HP:0003781)2.36392402
61Central scotoma (HP:0000603)2.31070465
62Impulsivity (HP:0100710)2.30876245
63Beaking of vertebral bodies (HP:0004568)2.26562447
64Abnormality of the ischium (HP:0003174)2.25170864
65Facial diplegia (HP:0001349)2.24919137
66Spontaneous hematomas (HP:0007420)2.23174755
67Hypoplasia of the thymus (HP:0000778)2.21132912
68Azoospermia (HP:0000027)2.21105380
69Portal hypertension (HP:0001409)2.19798525
70Congenital sensorineural hearing impairment (HP:0008527)2.18770265
71Hypoplastic ischia (HP:0003175)2.17469837
72Abnormality of the fovea (HP:0000493)2.14925074
73Impaired proprioception (HP:0010831)2.14823182
74Colitis (HP:0002583)2.13849195
75Widely spaced teeth (HP:0000687)2.11912345
76Retinal atrophy (HP:0001105)2.11260722
77Postaxial foot polydactyly (HP:0001830)2.09998413
78Thoracolumbar scoliosis (HP:0002944)2.08249250
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07364465
80Abnormality of the hepatic vasculature (HP:0006707)2.06117514
81Hypothermia (HP:0002045)2.05923629
82Asymmetric septal hypertrophy (HP:0001670)2.04704434
83Scotoma (HP:0000575)2.02995795
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02254197
85Tubulointerstitial fibrosis (HP:0005576)2.02241129
86Broad alveolar ridges (HP:0000187)2.02139365
87Stage 5 chronic kidney disease (HP:0003774)2.00776446
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5354736
89Dynein arm defect of respiratory motile cilia (HP:0012255)12.9050100
90Absent/shortened dynein arms (HP:0200106)12.9050100
91Decreased circulating renin level (HP:0003351)1.99848944
92Hemiparesis (HP:0001269)1.99770441
93Upper motor neuron abnormality (HP:0002127)1.99205667
94Protuberant abdomen (HP:0001538)1.98534781
95Conjugated hyperbilirubinemia (HP:0002908)1.97497492
96Abnormality of dental color (HP:0011073)1.95115483
97Agitation (HP:0000713)1.93920268
98Aortic regurgitation (HP:0001659)1.92576475
99Anterior segment dysgenesis (HP:0007700)1.88909016
100Ventricular fibrillation (HP:0001663)1.88480201
101Confusion (HP:0001289)1.87484594
102Congenital hepatic fibrosis (HP:0002612)1.85949329
103Gastrointestinal atresia (HP:0002589)1.85805219
104Abnormality of the renal cortex (HP:0011035)1.84233150
105Cone-rod dystrophy (HP:0000548)1.82906244
106Abnormal drinking behavior (HP:0030082)1.82246196
107Polydipsia (HP:0001959)1.82246196
108Abnormality of the anterior horn cell (HP:0006802)1.81897806
109Degeneration of anterior horn cells (HP:0002398)1.81897806
110Short ribs (HP:0000773)1.81373434
111Abnormality of the wing of the ilium (HP:0011867)1.81228497
112Absent frontal sinuses (HP:0002688)1.80709354
113Oculomotor apraxia (HP:0000657)1.80146403
114Abnormality of dentin (HP:0010299)1.79330012
115Aortic aneurysm (HP:0004942)1.76967368
116Abnormality of potassium homeostasis (HP:0011042)1.74526925
117Spastic tetraparesis (HP:0001285)1.74146884
118Abnormal gallbladder physiology (HP:0012438)1.73282621
119Cholecystitis (HP:0001082)1.73282621
120Abnormality of the dental root (HP:0006486)1.73180125
121Taurodontia (HP:0000679)1.73180125
122Abnormality of permanent molar morphology (HP:0011071)1.73180125
123J-shaped sella turcica (HP:0002680)1.72662504
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71953293
125Aplasia/Hypoplasia of the macula (HP:0008059)1.71651090
126Abnormality of salivation (HP:0100755)1.71479446
127Renal dysplasia (HP:0000110)1.70984942
128Type 2 muscle fiber atrophy (HP:0003554)1.70666406
129Prominent supraorbital ridges (HP:0000336)1.70118856
130Palpebral edema (HP:0100540)1.68897719
131Thyroid-stimulating hormone excess (HP:0002925)1.68756123
132Microglossia (HP:0000171)1.67137105
133Polyphagia (HP:0002591)1.65269660
134Type II lissencephaly (HP:0007260)1.64417307
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63607326
136Absent epiphyses (HP:0010577)1.63607326
137Abnormality of molar (HP:0011077)1.60805407
138Abnormality of molar morphology (HP:0011070)1.60805407
139Abnormality of the dental pulp (HP:0006479)1.60179525
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59214620
141Facial cleft (HP:0002006)1.58657485
142Abnormality of renal excretion (HP:0011036)1.57724467
143Postaxial hand polydactyly (HP:0001162)1.57312773
144Heterotopia (HP:0002282)1.56462298
145Aplasia/Hypoplasia of the fibula (HP:0006492)1.55735079
146Chronic sinusitis (HP:0011109)1.54714568
147Supernumerary spleens (HP:0009799)1.54294524
148Bell-shaped thorax (HP:0001591)1.53999536
149Dyschromatopsia (HP:0007641)1.51956312
150Deformed sella turcica (HP:0002681)1.44320116
15111 pairs of ribs (HP:0000878)1.42807625
152Short thorax (HP:0010306)1.42073240
153Broad distal phalanx of finger (HP:0009836)1.41530751
154Cystic liver disease (HP:0006706)1.40903221
155Median cleft lip (HP:0000161)1.37428533
156Abnormal biliary tract physiology (HP:0012439)1.35990409
157Bile duct proliferation (HP:0001408)1.35990409
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.35709870
159Nephropathy (HP:0000112)1.31781723
160Gait imbalance (HP:0002141)1.30119015
161Congenital primary aphakia (HP:0007707)1.29896298
162Choroideremia (HP:0001139)1.29099019
163Breast carcinoma (HP:0003002)1.28392550
164Decreased central vision (HP:0007663)1.26832711
165Aplasia/Hypoplasia of the lens (HP:0008063)1.26803881
166Abnormality of ocular smooth pursuit (HP:0000617)1.25472753
167Pancreatic fibrosis (HP:0100732)1.25186793
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.24913013
169Abnormal urine output (HP:0012590)1.24851094
170Short femoral neck (HP:0100864)1.23879437
171Conjunctival telangiectasia (HP:0000524)1.23574749
172Pachygyria (HP:0001302)1.22535004
173Decreased motor nerve conduction velocity (HP:0003431)1.22285619
174Cerebellar dysplasia (HP:0007033)1.16818808
175Selective tooth agenesis (HP:0001592)1.16585220
176Gaze-evoked nystagmus (HP:0000640)1.16501410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.02251811
2PDK49.02251811
3PDK25.85623544
4TESK14.90828331
5PRKD33.95467778
6FRK3.94964939
7ICK3.46393341
8PTK2B2.41526666
9WNK42.36037671
10PNCK2.33822792
11STK392.28697938
12BRD42.24880950
13INSRR2.24205172
14CAMKK22.21602230
15YES12.12618243
16EPHB21.93681319
17NEK21.91866072
18SGK4941.70862546
19SGK2231.70862546
20SGK21.49953388
21STK381.46593917
22MST41.37828025
23PLK21.34871023
24CASK1.31043753
25NLK1.29289280
26ZAK1.28386528
27PRKG21.23186724
28UHMK11.23120415
29MARK11.22308930
30ADRBK21.19995751
31MAPK131.18576991
32EPHA31.18400254
33VRK11.16656720
34PAK31.15970003
35CAMK41.10483711
36TLK11.07813533
37DYRK1B1.07260939
38MAPK151.05462548
39WNK11.05208908
40TYRO30.99790811
41PDK10.96268404
42PIK3CG0.94075184
43SGK10.93306995
44CCNB10.89464697
45DYRK20.89300720
46PASK0.87873190
47MKNK20.87673357
48STK30.87556679
49RPS6KA60.85547786
50TAF10.84524024
51GRK60.82347919
52CDC70.78716473
53DYRK30.77526612
54PRKCE0.77520122
55SGK30.76884253
56OXSR10.69109502
57TTK0.67776986
58GRK10.67357171
59RPS6KA50.67038372
60TNIK0.66092443
61PINK10.64369771
62IRAK10.64237379
63CAMK10.60113502
64MAP3K20.58667081
65FER0.58616381
66PBK0.56258893
67CHUK0.56027326
68RPS6KL10.55063181
69RPS6KC10.55063181
70WEE10.55012460
71HIPK20.51160491
72SYK0.50956023
73CAMK1G0.49463617
74NTRK30.48305792
75CHEK20.47943384
76TXK0.47364884
77CHEK10.47110901
78ATR0.47089418
79DDR20.44983087
80CSNK1G20.44256989
81TESK20.41882050
82PDPK10.40702355
83LMTK20.39535133
84OBSCN0.39093781
85NTRK20.38616641
86TIE10.37541545
87ADRBK10.36440187
88MAP4K20.36375056
89EEF2K0.36137725
90BMPR1B0.35169679
91TAOK30.35108493
92CDK190.34115806
93ATM0.33149427
94MUSK0.32287515
95TSSK60.31401757
96LATS10.31385335
97FGFR30.30661957
98STK38L0.30120222
99MAP2K60.28788681
100PAK10.28587250
101MTOR0.27231980
102RIPK40.26730453
103PRKCG0.25910982
104IRAK20.25743046
105PIM10.25452072
106CAMKK10.25283702
107MAP3K30.23779509
108CAMK2B0.23441892
109PRKCD0.22826670
110AKT20.22163681
111PAK20.21940586
112PLK10.21866921
113RPS6KA20.21866662
114PLK40.21356365
115PRKAA10.19647492
116RPS6KB10.19205921
117MAPKAPK50.18948124
118MARK20.18027979
119NEK60.11081762
120WNK30.10191889
121BRAF0.09714198
122CDK120.08767507
123MAP3K40.08451187
124MAP3K100.08298925
125PRKCZ0.07500845
126CDK150.07256184
127PAK40.07134359
128PRKCQ0.06546883
129BRSK20.05866477
130CSNK2A10.05252267
131CDK180.05130701
132CDK10.05092181
133PAK60.04128736
134CDK11A0.04104711
135CSNK1D0.04091186
136PRKACG0.03977633
137PRKG10.03922090
138GSK3B0.03719672
139CDK20.03583479
140MAPK80.03138162
141STK110.02935190
142MARK30.02568536
143CSF1R0.02201122
144CDK140.01957866
145RPS6KA10.01785332
146PRKACB0.01681016
147PRKDC0.01322345
148MAPK1-0.0494688
149PRKACA-0.0476384
150ZAP70-0.0415966
151AURKA-0.0400006
152CSK-0.0353676
153PRKCA-0.0339646
154MAPK10-0.0310918
155TAOK1-0.0239297
156BRSK1-0.0222855
157CAMK2A-0.0221029
158BUB1-0.0216517
159EGFR-0.0200938
160PDGFRB-0.0171476
161CDK3-0.0132241
162STK10-0.0131726
163RPS6KA3-0.0129155
164CSNK2A2-0.0079567
165PRKCB-0.0031066

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.30444623
2Pyruvate metabolism_Homo sapiens_hsa006204.49814306
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.42356399
4Fatty acid biosynthesis_Homo sapiens_hsa000613.54203360
5Propanoate metabolism_Homo sapiens_hsa006403.48116065
6Basal transcription factors_Homo sapiens_hsa030222.70194525
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69777474
8Linoleic acid metabolism_Homo sapiens_hsa005912.59550406
9Selenocompound metabolism_Homo sapiens_hsa004502.59098626
10Nicotine addiction_Homo sapiens_hsa050332.51441163
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.48547778
12Dorso-ventral axis formation_Homo sapiens_hsa043202.48142934
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.44816483
14* Glucagon signaling pathway_Homo sapiens_hsa049222.43363749
15Pentose phosphate pathway_Homo sapiens_hsa000302.40433176
16Fanconi anemia pathway_Homo sapiens_hsa034602.23530709
17Glycerolipid metabolism_Homo sapiens_hsa005612.03013582
18* Glutamatergic synapse_Homo sapiens_hsa047241.92569113
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89229078
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.85709308
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.82872719
22Gap junction_Homo sapiens_hsa045401.82509968
23Type I diabetes mellitus_Homo sapiens_hsa049401.79488556
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78298561
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.75174799
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74379899
27Huntingtons disease_Homo sapiens_hsa050161.73950173
28PPAR signaling pathway_Homo sapiens_hsa033201.70617037
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58471477
30* Oocyte meiosis_Homo sapiens_hsa041141.49448937
31Long-term depression_Homo sapiens_hsa047301.49335910
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.46140537
33Carbon metabolism_Homo sapiens_hsa012001.45544977
34Serotonergic synapse_Homo sapiens_hsa047261.45458930
35Morphine addiction_Homo sapiens_hsa050321.45402589
36Fructose and mannose metabolism_Homo sapiens_hsa000511.44623843
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.43315068
38Nitrogen metabolism_Homo sapiens_hsa009101.42124189
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.39750092
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37774712
41Phototransduction_Homo sapiens_hsa047441.37371671
42Cardiac muscle contraction_Homo sapiens_hsa042601.35849417
43GABAergic synapse_Homo sapiens_hsa047271.33413981
44mRNA surveillance pathway_Homo sapiens_hsa030151.33355467
45Type II diabetes mellitus_Homo sapiens_hsa049301.33072732
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27260797
47Fat digestion and absorption_Homo sapiens_hsa049751.24610645
48Ether lipid metabolism_Homo sapiens_hsa005651.21657090
49RNA transport_Homo sapiens_hsa030131.20380921
50Cholinergic synapse_Homo sapiens_hsa047251.19278972
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16311680
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16260236
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15471104
54Fatty acid metabolism_Homo sapiens_hsa012121.12742543
55Antigen processing and presentation_Homo sapiens_hsa046121.12074145
56African trypanosomiasis_Homo sapiens_hsa051431.09288823
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02811719
58Circadian rhythm_Homo sapiens_hsa047101.02717023
59Fatty acid degradation_Homo sapiens_hsa000711.02214534
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02095457
61Allograft rejection_Homo sapiens_hsa053301.01648010
62Purine metabolism_Homo sapiens_hsa002301.00423696
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96719874
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96100613
65Mineral absorption_Homo sapiens_hsa049780.95439327
66Caffeine metabolism_Homo sapiens_hsa002320.95311879
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95132825
68Biosynthesis of amino acids_Homo sapiens_hsa012300.94559918
69* MAPK signaling pathway_Homo sapiens_hsa040100.87864143
70* Oxytocin signaling pathway_Homo sapiens_hsa049210.87319799
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85522386
72* Long-term potentiation_Homo sapiens_hsa047200.85291551
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84488217
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84065922
75ABC transporters_Homo sapiens_hsa020100.83815171
76* Amphetamine addiction_Homo sapiens_hsa050310.83542059
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82102137
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80399633
79Regulation of autophagy_Homo sapiens_hsa041400.79464321
80Autoimmune thyroid disease_Homo sapiens_hsa053200.79027057
81Glutathione metabolism_Homo sapiens_hsa004800.78901981
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78891369
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78495185
84Estrogen signaling pathway_Homo sapiens_hsa049150.77586691
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77249311
86Graft-versus-host disease_Homo sapiens_hsa053320.76876967
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.73438229
88* T cell receptor signaling pathway_Homo sapiens_hsa046600.70062199
89Collecting duct acid secretion_Homo sapiens_hsa049660.69717289
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69536648
91Chemical carcinogenesis_Homo sapiens_hsa052040.64843069
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.63382354
93Arachidonic acid metabolism_Homo sapiens_hsa005900.61812714
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60791792
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60173694
96Hedgehog signaling pathway_Homo sapiens_hsa043400.60046156
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.59343925
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.58466434
99AMPK signaling pathway_Homo sapiens_hsa041520.53908035
100Insulin secretion_Homo sapiens_hsa049110.53674773
101Platelet activation_Homo sapiens_hsa046110.52243695
102Butanoate metabolism_Homo sapiens_hsa006500.51267794
103Legionellosis_Homo sapiens_hsa051340.50041294
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49061877
105Systemic lupus erythematosus_Homo sapiens_hsa053220.48534597
106Tryptophan metabolism_Homo sapiens_hsa003800.47897100
107Ovarian steroidogenesis_Homo sapiens_hsa049130.47531260
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47462284
109Thyroid hormone synthesis_Homo sapiens_hsa049180.47106560
110GnRH signaling pathway_Homo sapiens_hsa049120.46739214
111Chemokine signaling pathway_Homo sapiens_hsa040620.44986524
112Endocytosis_Homo sapiens_hsa041440.44755310
113Bile secretion_Homo sapiens_hsa049760.41460546
114N-Glycan biosynthesis_Homo sapiens_hsa005100.41397400
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41120066
116* Renin secretion_Homo sapiens_hsa049240.40710960
117Prolactin signaling pathway_Homo sapiens_hsa049170.39536759
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.38583030
119Metabolic pathways_Homo sapiens_hsa011000.38556748
120Inositol phosphate metabolism_Homo sapiens_hsa005620.38169303
121Synaptic vesicle cycle_Homo sapiens_hsa047210.36958790
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.36086364
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34421251
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33993483
125Taste transduction_Homo sapiens_hsa047420.33377833
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33275320
127Renin-angiotensin system_Homo sapiens_hsa046140.32411150
128* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32349884
129Circadian entrainment_Homo sapiens_hsa047130.32057807
130Pancreatic secretion_Homo sapiens_hsa049720.31855915
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30633106
132Salivary secretion_Homo sapiens_hsa049700.30334728
133RNA degradation_Homo sapiens_hsa030180.29620535
134* Calcium signaling pathway_Homo sapiens_hsa040200.29109999
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28619454
136Alcoholism_Homo sapiens_hsa050340.28197694
137Pyrimidine metabolism_Homo sapiens_hsa002400.27189297
138Gastric acid secretion_Homo sapiens_hsa049710.25354485
139cAMP signaling pathway_Homo sapiens_hsa040240.24959378
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24127480
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23275270
142Protein digestion and absorption_Homo sapiens_hsa049740.22084204
143Homologous recombination_Homo sapiens_hsa034400.21627718
144Cell cycle_Homo sapiens_hsa041100.20430016
145Cocaine addiction_Homo sapiens_hsa050300.19593282
146Viral carcinogenesis_Homo sapiens_hsa052030.19521028
147Retinol metabolism_Homo sapiens_hsa008300.17309975
148Sphingolipid metabolism_Homo sapiens_hsa006000.13531145
149Olfactory transduction_Homo sapiens_hsa047400.13138666
150Dopaminergic synapse_Homo sapiens_hsa047280.11241447
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10562290
152Salmonella infection_Homo sapiens_hsa051320.10177325
153Sulfur metabolism_Homo sapiens_hsa009200.09222588

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