PPP3CB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65658521
2vocalization behavior (GO:0071625)5.53220829
3locomotory exploration behavior (GO:0035641)5.37989774
4synaptic vesicle exocytosis (GO:0016079)5.33354100
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32538301
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31640151
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.29404661
8sarcoplasmic reticulum calcium ion transport (GO:0070296)5.28597207
9synaptic vesicle maturation (GO:0016188)5.13766932
10regulation of glutamate receptor signaling pathway (GO:1900449)4.97526604
11protein localization to synapse (GO:0035418)4.94856722
12glutamate secretion (GO:0014047)4.94032100
13neuron cell-cell adhesion (GO:0007158)4.93465189
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.85620087
15regulation of synaptic vesicle exocytosis (GO:2000300)4.75576940
16layer formation in cerebral cortex (GO:0021819)4.65240559
17exploration behavior (GO:0035640)4.62804729
18muscle filament sliding (GO:0030049)4.54715953
19actin-myosin filament sliding (GO:0033275)4.54715953
20glutamate receptor signaling pathway (GO:0007215)4.53961182
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.48180585
22neuronal action potential propagation (GO:0019227)4.44090707
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.37735920
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33121944
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.27887082
26regulation of synaptic vesicle transport (GO:1902803)4.26752002
27neuron recognition (GO:0008038)4.22288232
28dendritic spine morphogenesis (GO:0060997)4.16175223
29regulation of neuronal synaptic plasticity (GO:0048168)4.14846702
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.09440178
31synaptic transmission, glutamatergic (GO:0035249)4.09070308
32neurotransmitter secretion (GO:0007269)4.07723635
33regulation of cell communication by electrical coupling (GO:0010649)4.05847306
34neuron-neuron synaptic transmission (GO:0007270)4.04088384
35regulation of synapse structural plasticity (GO:0051823)3.96151737
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.91177222
37regulation of dendritic spine morphogenesis (GO:0061001)3.89293169
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.88260114
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86081397
40proline transport (GO:0015824)3.84567378
41long-term memory (GO:0007616)3.83465634
42positive regulation of synapse maturation (GO:0090129)3.81591415
43axonal fasciculation (GO:0007413)3.79608845
44actin-mediated cell contraction (GO:0070252)3.78415355
45neurotransmitter-gated ion channel clustering (GO:0072578)3.72868135
46regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.72177536
47cell communication by electrical coupling (GO:0010644)3.70438989
48regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.70388290
49regulation of postsynaptic membrane potential (GO:0060078)3.68368791
50cellular potassium ion homeostasis (GO:0030007)3.66516647
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.60668866
52activation of protein kinase A activity (GO:0034199)3.60535525
53gamma-aminobutyric acid transport (GO:0015812)3.59106441
54skeletal muscle contraction (GO:0003009)3.51151878
55striated muscle contraction (GO:0006941)3.51108578
56synaptic vesicle endocytosis (GO:0048488)3.51035846
57long-term synaptic potentiation (GO:0060291)3.50510255
58positive regulation of membrane potential (GO:0045838)3.50077747
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49657602
60postsynaptic membrane organization (GO:0001941)3.49077541
61response to histamine (GO:0034776)3.47503858
62* regulation of synaptic plasticity (GO:0048167)3.47438902
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.43940262
64regulation of ARF protein signal transduction (GO:0032012)3.43506316
65presynaptic membrane assembly (GO:0097105)3.42478849
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42102632
67transmission of nerve impulse (GO:0019226)3.39491880
68regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.39110610
69cardiac muscle contraction (GO:0060048)3.37616142
70regulation of dendritic spine development (GO:0060998)3.36710907
71behavioral defense response (GO:0002209)3.35423427
72behavioral fear response (GO:0001662)3.35423427
73potassium ion import (GO:0010107)3.34756128
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33165839
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33156634
76neurotransmitter transport (GO:0006836)3.32278057
77regulation of vesicle fusion (GO:0031338)3.32191191
78regulation of relaxation of muscle (GO:1901077)3.31719652
79potassium ion homeostasis (GO:0055075)3.31305982
80regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.26433071
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.26411066
82dendrite morphogenesis (GO:0048813)3.26058031
83neuromuscular synaptic transmission (GO:0007274)3.25340069
84positive regulation of neurotransmitter secretion (GO:0001956)3.24789137
85vesicle transport along microtubule (GO:0047496)3.24357203
86cell communication involved in cardiac conduction (GO:0086065)3.22643880
87innervation (GO:0060384)3.22481314
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22279444
89regulation of neurotransmitter secretion (GO:0046928)3.21927197
90fear response (GO:0042596)3.19845737
91positive regulation of dendritic spine development (GO:0060999)3.17028952
92dendritic spine organization (GO:0097061)3.14865002
93presynaptic membrane organization (GO:0097090)3.14304800
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12702443
95regulation of calcium ion transmembrane transporter activity (GO:1901019)3.11236275
96regulation of calcium ion transmembrane transport (GO:1903169)3.11236275
97detection of calcium ion (GO:0005513)3.10505979
98membrane depolarization (GO:0051899)3.10433857
99neuromuscular process controlling balance (GO:0050885)3.08854491
100synapse assembly (GO:0007416)3.08508120
101organelle transport along microtubule (GO:0072384)3.07843615
102sodium ion export (GO:0071436)3.07314749
103regulation of neurotransmitter levels (GO:0001505)3.05228548
104myofibril assembly (GO:0030239)3.04945298
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03988274
106negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.02682380
107creatine metabolic process (GO:0006600)3.02280078
108regulation of voltage-gated calcium channel activity (GO:1901385)3.01198072
109regulation of female receptivity (GO:0045924)3.00840327
110* learning (GO:0007612)3.00214880
111cerebellar Purkinje cell differentiation (GO:0021702)3.00186976
112auditory behavior (GO:0031223)2.99555976
113regulation of skeletal muscle contraction (GO:0014819)2.99289516
114central nervous system projection neuron axonogenesis (GO:0021952)2.98408314
115actin filament-based movement (GO:0030048)2.97237011
116positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.97152435
117cerebellar granule cell differentiation (GO:0021707)2.96885189
118positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96825745
119positive regulation of neurotransmitter transport (GO:0051590)2.95711949
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95512152
121membrane depolarization during action potential (GO:0086010)2.95457180
122synapse organization (GO:0050808)2.94618737
123cellular sodium ion homeostasis (GO:0006883)2.92809365
124cell migration in hindbrain (GO:0021535)2.92278646
125plasma membrane repair (GO:0001778)2.91687783
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90952478
127regulation of neurotransmitter transport (GO:0051588)2.90231006
128synaptic transmission (GO:0007268)2.89833573
129regulation of membrane repolarization (GO:0060306)2.89555593
130negative regulation of dendrite morphogenesis (GO:0050774)2.88980509
131neuronal ion channel clustering (GO:0045161)2.88762613
132mating behavior (GO:0007617)2.87994922
133regulation of glutamate secretion (GO:0014048)2.87706198
134L-amino acid import (GO:0043092)2.86833702
135long term synaptic depression (GO:0060292)2.86755060
136regulation of synapse maturation (GO:0090128)2.85849916
137* intraspecies interaction between organisms (GO:0051703)2.85272907
138* social behavior (GO:0035176)2.85272907
139* regulation of synaptic transmission (GO:0050804)2.84761547
140regulation of actin filament-based movement (GO:1903115)2.84045776
141negative regulation of potassium ion transmembrane transport (GO:1901380)2.79796823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.56645880
2* GBX2_23144817_ChIP-Seq_PC3_Human3.49567448
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16943603
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15307126
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05623840
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70129231
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70129231
8REST_21632747_ChIP-Seq_MESCs_Mouse2.68953325
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66359169
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.58848180
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55572538
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52450898
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50633794
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48601882
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47443144
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42302479
17DROSHA_22980978_ChIP-Seq_HELA_Human2.30768935
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.21160964
19AR_21572438_ChIP-Seq_LNCaP_Human2.15042843
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.14997957
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14640862
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.13549219
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.11602903
24TAF15_26573619_Chip-Seq_HEK293_Human2.08110958
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05628703
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98151964
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96933426
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94958310
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94175751
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87148993
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83386540
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78416206
33SMAD4_21799915_ChIP-Seq_A2780_Human1.77648690
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70428708
35ZNF274_21170338_ChIP-Seq_K562_Hela1.67999816
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61637440
37P300_19829295_ChIP-Seq_ESCs_Human1.58175810
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57538133
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55537561
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55002326
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54137074
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.45736415
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43417218
44FUS_26573619_Chip-Seq_HEK293_Human1.43301445
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.41487724
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.41086664
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40450417
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40304654
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40297351
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38518975
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38104934
52AR_25329375_ChIP-Seq_VCAP_Human1.35405107
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33980910
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.33818453
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32601276
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29109683
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.29102004
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.28154588
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26263432
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.25859174
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25671821
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25369482
63STAT3_23295773_ChIP-Seq_U87_Human1.24885395
64AR_19668381_ChIP-Seq_PC3_Human1.22193485
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21523671
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21163433
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21161920
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19197935
69* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19072717
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.18972789
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17213785
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17127350
73TP53_16413492_ChIP-PET_HCT116_Human1.17087257
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15030161
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.14822542
76RNF2_27304074_Chip-Seq_NSC_Mouse1.13807285
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.13574479
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13307588
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13080426
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13033871
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12072935
82IGF1R_20145208_ChIP-Seq_DFB_Human1.12055555
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.11908982
84TCF4_23295773_ChIP-Seq_U87_Human1.11766015
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10518483
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09803822
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09727963
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09607836
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09463597
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07062928
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05999474
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04276187
93RUNX2_22187159_ChIP-Seq_PCA_Human1.04238466
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04164042
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03561360
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02759116
97AHR_22903824_ChIP-Seq_MCF-7_Human1.02556430
98TP53_18474530_ChIP-ChIP_U2OS_Human1.01340218
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00899183
100VDR_22108803_ChIP-Seq_LS180_Human1.00712477
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00615257
102JUN_21703547_ChIP-Seq_K562_Human1.00437844
103BCAT_22108803_ChIP-Seq_LS180_Human1.00233914
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99635491
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99194910
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99194910
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96845573
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95702819
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.95669143
110* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95289701
111ER_23166858_ChIP-Seq_MCF-7_Human0.94973341
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94184415
113* TP53_20018659_ChIP-ChIP_R1E_Mouse0.92712807
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91517654
115KDM2B_26808549_Chip-Seq_K562_Human0.91200207
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90500249
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.89956651
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.89956651
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89758295
120CTCF_27219007_Chip-Seq_Bcells_Human0.88701813
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87330386
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87330386
123DPY_21335234_ChIP-Seq_ESCs_Mouse0.86456176
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84827304
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84677681
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.84633934
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83126393
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82654757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.50961220
2MP0003880_abnormal_central_pattern5.19178489
3MP0003635_abnormal_synaptic_transmissio4.27320209
4MP0004270_analgesia4.00608537
5MP0002063_abnormal_learning/memory/cond3.48673468
6MP0009745_abnormal_behavioral_response3.45257504
7MP0002064_seizures3.09907236
8MP0001968_abnormal_touch/_nociception2.99714965
9MP0002572_abnormal_emotion/affect_behav2.84811588
10MP0009046_muscle_twitch2.82349302
11MP0000749_muscle_degeneration2.79505344
12MP0002734_abnormal_mechanical_nocicepti2.57516264
13MP0005423_abnormal_somatic_nervous2.53385827
14MP0002272_abnormal_nervous_system2.44247133
15MP0001486_abnormal_startle_reflex2.43919623
16MP0001440_abnormal_grooming_behavior2.31005422
17MP0002736_abnormal_nociception_after2.30103848
18MP0002735_abnormal_chemical_nociception2.21179329
19MP0001501_abnormal_sleep_pattern2.18883483
20MP0002822_catalepsy2.17539487
21MP0009780_abnormal_chondrocyte_physiolo2.08680491
22MP0002733_abnormal_thermal_nociception2.04643815
23MP0000778_abnormal_nervous_system2.02128471
24MP0002067_abnormal_sensory_capabilities1.98792026
25MP0002184_abnormal_innervation1.96103900
26MP0003329_amyloid_beta_deposits1.91926683
27MP0001970_abnormal_pain_threshold1.88553725
28* MP0000759_abnormal_skeletal_muscle1.82529687
29MP0004924_abnormal_behavior1.79933331
30MP0005386_behavior/neurological_phenoty1.79933331
31MP0002106_abnormal_muscle_physiology1.77832869
32MP0004811_abnormal_neuron_physiology1.77391986
33MP0002557_abnormal_social/conspecific_i1.77031416
34MP0008569_lethality_at_weaning1.74541229
35MP0006276_abnormal_autonomic_nervous1.73431182
36* MP0004087_abnormal_muscle_fiber1.71725266
37MP0002909_abnormal_adrenal_gland1.70552405
38MP0001984_abnormal_olfaction1.69529331
39MP0002837_dystrophic_cardiac_calcinosis1.65091038
40MP0004145_abnormal_muscle_electrophysio1.64753602
41MP0004084_abnormal_cardiac_muscle1.64686818
42MP0000955_abnormal_spinal_cord1.53549049
43MP0005369_muscle_phenotype1.52607536
44MP0004858_abnormal_nervous_system1.51324537
45MP0003123_paternal_imprinting1.44481670
46MP0003690_abnormal_glial_cell1.43359973
47MP0003787_abnormal_imprinting1.42178941
48* MP0002066_abnormal_motor_capabilities/c1.40542940
49MP0002882_abnormal_neuron_morphology1.39671977
50MP0001529_abnormal_vocalization1.38115988
51MP0002269_muscular_atrophy1.37663881
52MP0003879_abnormal_hair_cell1.37028022
53MP0002332_abnormal_exercise_endurance1.35195819
54MP0000751_myopathy1.34934711
55MP0004885_abnormal_endolymph1.28049034
56MP0001188_hyperpigmentation1.27117682
57MP0005645_abnormal_hypothalamus_physiol1.20292721
58MP0001502_abnormal_circadian_rhythm1.19307675
59MP0001905_abnormal_dopamine_level1.19258438
60MP0003633_abnormal_nervous_system1.18846303
61MP0002152_abnormal_brain_morphology1.17464705
62MP0003122_maternal_imprinting1.16268816
63MP0005646_abnormal_pituitary_gland1.15805069
64MP0000750_abnormal_muscle_regeneration1.13586324
65MP0002972_abnormal_cardiac_muscle1.12594566
66MP0000920_abnormal_myelination1.10118474
67MP0004142_abnormal_muscle_tone1.05401801
68MP0000569_abnormal_digit_pigmentation1.05321436
69MP0004233_abnormal_muscle_weight1.01331272
70MP0003631_nervous_system_phenotype1.01254652
71MP0000013_abnormal_adipose_tissue1.00329557
72MP0000733_abnormal_muscle_development0.98330339
73MP0010234_abnormal_vibrissa_follicle0.97182844
74MP0002069_abnormal_eating/drinking_beha0.92967487
75MP0004215_abnormal_myocardial_fiber0.91191937
76MP0002108_abnormal_muscle_morphology0.89954125
77MP0004085_abnormal_heartbeat0.89312946
78MP0008874_decreased_physiological_sensi0.89176698
79MP0002971_abnormal_brown_adipose0.87531540
80MP0004510_myositis0.87365830
81MP0004742_abnormal_vestibular_system0.86904323
82MP0005187_abnormal_penis_morphology0.86203334
83MP0008961_abnormal_basal_metabolism0.85518790
84MP0005330_cardiomyopathy0.85476953
85MP0000604_amyloidosis0.83570561
86MP0005499_abnormal_olfactory_system0.82215578
87MP0005394_taste/olfaction_phenotype0.82215578
88MP0002229_neurodegeneration0.81608579
89MP0005409_darkened_coat_color0.81531759
90MP0000631_abnormal_neuroendocrine_gland0.81331582
91MP0005535_abnormal_body_temperature0.81105317
92MP0008872_abnormal_physiological_respon0.80216252
93MP0005551_abnormal_eye_electrophysiolog0.79137809
94MP0003045_fibrosis0.78661594
95MP0010386_abnormal_urinary_bladder0.76799986
96MP0003283_abnormal_digestive_organ0.74453384
97* MP0004484_altered_response_of0.72444336
98MP0002752_abnormal_somatic_nervous0.71578172
99MP0001963_abnormal_hearing_physiology0.71536875
100MP0006138_congestive_heart_failure0.70832554
101MP0000003_abnormal_adipose_tissue0.70767435
102MP0004130_abnormal_muscle_cell0.67810303
103MP0003632_abnormal_nervous_system0.67653032
104MP0003634_abnormal_glial_cell0.67511522
105MP0003861_abnormal_nervous_system0.66929332
106MP0000747_muscle_weakness0.65956927
107MP0005620_abnormal_muscle_contractility0.65648196
108MP0010630_abnormal_cardiac_muscle0.65395676
109MP0003137_abnormal_impulse_conducting0.65328920
110MP0001348_abnormal_lacrimal_gland0.64274083
111MP0001177_atelectasis0.64229028
112MP0005375_adipose_tissue_phenotype0.63462347
113MP0002234_abnormal_pharynx_morphology0.62954434
114MP0002090_abnormal_vision0.59740227
115MP0001943_abnormal_respiration0.59633636
116MP0005623_abnormal_meninges_morphology0.58034552
117MP0001299_abnormal_eye_distance/0.57162013
118MP0001664_abnormal_digestion0.57053931
119MP0002876_abnormal_thyroid_physiology0.55660049
120MP0001485_abnormal_pinna_reflex0.55498949
121MP0003646_muscle_fatigue0.54691091
122MP0003075_altered_response_to0.54482593
123MP0004036_abnormal_muscle_relaxation0.52915769
124MP0010769_abnormal_survival0.52249556

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.44985057
2Muscle fiber inclusion bodies (HP:0100299)6.61175012
3Nemaline bodies (HP:0003798)6.53213869
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.35058357
5Focal seizures (HP:0007359)5.66706176
6Myokymia (HP:0002411)5.56892979
7Type 1 muscle fiber predominance (HP:0003803)5.50105822
8Visual hallucinations (HP:0002367)5.46724301
9Epileptic encephalopathy (HP:0200134)4.80336108
10Atonic seizures (HP:0010819)4.75077021
11Absence seizures (HP:0002121)4.41051175
12Exercise-induced muscle cramps (HP:0003710)4.38001738
13Febrile seizures (HP:0002373)4.10622092
14Distal arthrogryposis (HP:0005684)4.06273439
15Dialeptic seizures (HP:0011146)3.93800676
16Broad-based gait (HP:0002136)3.91825041
17Hyperventilation (HP:0002883)3.89626390
18Progressive cerebellar ataxia (HP:0002073)3.83972268
19Generalized tonic-clonic seizures (HP:0002069)3.82348603
20Round ear (HP:0100830)3.72494687
21Hyporeflexia of lower limbs (HP:0002600)3.70766678
22Calf muscle hypertrophy (HP:0008981)3.62824549
23EMG: myopathic abnormalities (HP:0003458)3.53345398
24Poor eye contact (HP:0000817)3.53219970
25Supranuclear gaze palsy (HP:0000605)3.50958959
26Muscle fiber splitting (HP:0003555)3.46686688
27Papilledema (HP:0001085)3.44923887
28Subaortic stenosis (HP:0001682)3.39909124
29Abnormality of the left ventricular outflow tract (HP:0011103)3.39909124
30Sudden death (HP:0001699)3.35801596
31Bundle branch block (HP:0011710)3.35687441
32Amblyopia (HP:0000646)3.34117650
33Difficulty running (HP:0009046)3.30223665
34Cerebral inclusion bodies (HP:0100314)3.28804460
35Myopathic facies (HP:0002058)3.26424720
36Drooling (HP:0002307)3.25089036
37Excessive salivation (HP:0003781)3.25089036
38Action tremor (HP:0002345)3.23128405
39Abnormal social behavior (HP:0012433)3.18905340
40Impaired social interactions (HP:0000735)3.18905340
41Abnormality of skeletal muscle fiber size (HP:0012084)3.15754235
42Truncal ataxia (HP:0002078)3.12887064
43Impaired vibration sensation in the lower limbs (HP:0002166)3.12691152
44Mutism (HP:0002300)3.11863370
45Depression (HP:0000716)3.06103368
46Abnormality of the calf musculature (HP:0001430)3.04167570
47Gaze-evoked nystagmus (HP:0000640)3.01976364
48Ulnar deviation of the wrist (HP:0003049)2.99598938
49Dysdiadochokinesis (HP:0002075)2.97614138
50Diplopia (HP:0000651)2.97302260
51Abnormality of binocular vision (HP:0011514)2.97302260
52Increased variability in muscle fiber diameter (HP:0003557)2.96617411
53Urinary bladder sphincter dysfunction (HP:0002839)2.91586429
54Termporal pattern (HP:0011008)2.88155761
55Insidious onset (HP:0003587)2.88155761
56Dysmetria (HP:0001310)2.85408109
57Anxiety (HP:0000739)2.85011175
58Calcaneovalgus deformity (HP:0001848)2.78510154
59Frequent falls (HP:0002359)2.78072094
60Progressive inability to walk (HP:0002505)2.77889768
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.75153689
62Neurofibrillary tangles (HP:0002185)2.75121645
63Ankle clonus (HP:0011448)2.69836419
64Amyotrophic lateral sclerosis (HP:0007354)2.69661235
65Urinary urgency (HP:0000012)2.67939313
66Stereotypic behavior (HP:0000733)2.67565874
67Myoglobinuria (HP:0002913)2.62885654
68Epileptiform EEG discharges (HP:0011182)2.61633764
69Hemiparesis (HP:0001269)2.61400292
70Impaired smooth pursuit (HP:0007772)2.60735444
71Genetic anticipation (HP:0003743)2.60608461
72Neck muscle weakness (HP:0000467)2.60073933
73Rimmed vacuoles (HP:0003805)2.58895135
74EMG: neuropathic changes (HP:0003445)2.58409027
75Inappropriate behavior (HP:0000719)2.54153801
76Absent speech (HP:0001344)2.53167239
77Abnormality of the lower motor neuron (HP:0002366)2.52093552
78Abnormal eating behavior (HP:0100738)2.51411111
79Myotonia (HP:0002486)2.49551761
80EEG with generalized epileptiform discharges (HP:0011198)2.47330192
81Deformed tarsal bones (HP:0008119)2.45580563
82Abnormality of the corticospinal tract (HP:0002492)2.44572867
83Asymmetric septal hypertrophy (HP:0001670)2.38267392
84Postural instability (HP:0002172)2.38143438
85Inability to walk (HP:0002540)2.38039452
86Muscle stiffness (HP:0003552)2.37375253
87Heart block (HP:0012722)2.35812699
88Rhabdomyolysis (HP:0003201)2.32763696
89Bradykinesia (HP:0002067)2.32755072
90Hypsarrhythmia (HP:0002521)2.30248208
91Dysmetric saccades (HP:0000641)2.29272791
92Limb dystonia (HP:0002451)2.28614991
93Fetal akinesia sequence (HP:0001989)2.27674679
94Increased connective tissue (HP:0009025)2.20765310
95Scanning speech (HP:0002168)2.20049114
96Abnormal atrioventricular conduction (HP:0005150)2.18744852
97Spastic gait (HP:0002064)2.18687749
98Megalencephaly (HP:0001355)2.18619334
99Absent phalangeal crease (HP:0006109)2.18530029
100Abnormality of ocular smooth pursuit (HP:0000617)2.17943059
101Slender build (HP:0001533)2.14303330
102Abnormality of salivation (HP:0100755)2.13686837
103Protruding tongue (HP:0010808)2.10075865
104Mildly elevated creatine phosphokinase (HP:0008180)2.09194522
105Apathy (HP:0000741)2.09098955
106Generalized myoclonic seizures (HP:0002123)2.07284004
107Shoulder girdle muscle weakness (HP:0003547)2.06786060
108Agitation (HP:0000713)2.05408848
109Rapidly progressive (HP:0003678)2.03785665
110Tetraplegia (HP:0002445)2.03553112
111Exercise-induced myalgia (HP:0003738)2.03053956
112Abnormality of the foot musculature (HP:0001436)2.02215828
113Lower limb muscle weakness (HP:0007340)2.01248481
114Impaired vibratory sensation (HP:0002495)2.01195561
115Ventricular fibrillation (HP:0001663)2.00425310
116Intention tremor (HP:0002080)1.99930720
117Polyphagia (HP:0002591)1.99108506
118Ankyloglossia (HP:0010296)1.98929119
119Lower limb asymmetry (HP:0100559)1.98619566
120Hemiplegia (HP:0002301)1.97593822
121Torticollis (HP:0000473)1.96822041
122Foot dorsiflexor weakness (HP:0009027)1.96674840
123Hyperthyroidism (HP:0000836)1.95586831
124Lower limb amyotrophy (HP:0007210)1.95196762
125Focal dystonia (HP:0004373)1.94296565
126Pheochromocytoma (HP:0002666)1.93667058
127Distal lower limb muscle weakness (HP:0009053)1.92524622
128Status epilepticus (HP:0002133)1.92418977
129Rigidity (HP:0002063)1.92042415
130Obstructive sleep apnea (HP:0002870)1.90876051
131Malignant hyperthermia (HP:0002047)1.90720155
132Atrioventricular block (HP:0001678)1.89096509
133Gait ataxia (HP:0002066)1.86309357
134Syncope (HP:0001279)1.84869606
135Blue irides (HP:0000635)1.84759464
136Psychosis (HP:0000709)1.84614388
137Insomnia (HP:0100785)1.84303574
138Diminished motivation (HP:0000745)1.83231160
139Sporadic (HP:0003745)1.83077409
140Distal lower limb amyotrophy (HP:0008944)1.83047698
141Pointed chin (HP:0000307)1.82984184
142Annular pancreas (HP:0001734)1.81244287
143Gowers sign (HP:0003391)1.80867787
144Neuronal loss in central nervous system (HP:0002529)1.80798850
145Akinesia (HP:0002304)1.80191552
146Aqueductal stenosis (HP:0002410)1.79339949
147Delusions (HP:0000746)1.78667457
148Muscle hypertrophy of the lower extremities (HP:0008968)1.77855054
149Autism (HP:0000717)1.77739029
150Widely spaced teeth (HP:0000687)1.77362796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.40636807
2EPHA44.32756424
3NTRK34.29707854
4MARK13.72647762
5MAP3K93.71552731
6MAP3K43.30702012
7RIPK42.88658700
8MINK12.75622887
9MAP2K72.71665669
10TTN2.31412297
11PNCK2.22108621
12DAPK22.20298826
13MAP3K122.19764295
14MAP2K42.19755123
15KSR22.18919480
16PAK61.99330480
17KSR11.97120701
18SIK21.92603009
19PLK21.87525943
20NTRK21.83023861
21CASK1.79142694
22DAPK11.57787119
23CAMKK11.50265850
24NTRK11.49242705
25CDK51.49224047
26RIPK11.40166966
27PRKD31.37230019
28MAPK131.36626916
29PHKG11.36531333
30PHKG21.36531333
31GRK51.36298261
32MAP3K21.32376351
33FES1.20407214
34BMPR21.20148035
35LATS21.15467852
36PRKCG1.13483574
37TNIK1.10956079
38ARAF1.04661582
39NME11.04463967
40CDK191.03049038
41PIK3CG1.02944575
42MOS1.02186097
43PTK2B1.01240418
44CAMK2A1.00742569
45MAP3K130.98441803
46CAMKK20.98100867
47RAF10.97894936
48LIMK10.96909034
49UHMK10.96576235
50WNK10.96171221
51TYRO30.95948879
52RET0.91169734
53STK380.89458835
54CAMK40.88450127
55PRPF4B0.87270650
56CDK140.85480281
57DYRK1A0.83918187
58CDK180.83706258
59STK110.82338520
60CDK150.81312975
61CSNK1G20.80704583
62CAMK2B0.80109914
63PAK30.77016248
64PDGFRA0.74036233
65MAP3K60.72660624
66CAMK10.71780051
67TAOK10.71547801
68SGK10.71060058
69CAMK1G0.70974205
70FGR0.70942660
71ICK0.70746258
72CDK11A0.70098922
73CCNB10.64499646
74MARK20.63960293
75BRAF0.62576851
76SCYL20.62387912
77MAPK120.60927348
78SGK4940.58784026
79SGK2230.58784026
80PRKCH0.58393947
81TRIB30.57144084
82TRPM70.56705107
83SGK20.56113159
84PDK10.55672585
85MAPK70.55595229
86ERBB30.54715534
87DMPK0.52553044
88MAP3K70.51691981
89PRKG10.50174763
90MAP3K10.49596774
91SGK30.49534839
92PRKCZ0.49177900
93PDPK10.48534621
94FYN0.46737512
95PRKCE0.46448989
96ALK0.46215967
97FER0.44909236
98MAP2K60.44604857
99ROCK10.43891355
100GRK60.43869183
101RPS6KA30.43839195
102MAP2K10.43646658
103DYRK1B0.42165144
104MAPK100.41640128
105TESK10.41309731
106CAMK2D0.41089424
107CDC42BPA0.40871001
108PRKAA10.39996737
109MAP3K110.39412488
110OXSR10.38783287
111MAPK40.38773404
112MAP2K30.35761376
113TNK20.34157220
114GRK70.32800858
115FGFR20.31837168
116PRKCB0.31732670
117CAMK2G0.30906399
118ROCK20.29773074
119FGFR30.29347909
120PINK10.26510939
121RPS6KA20.26466226
122PKN10.25826051
123CSNK1E0.25502039
124PDK40.25491269
125PDK30.25491269

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68613766
2* Long-term potentiation_Homo sapiens_hsa047202.88113641
3Synaptic vesicle cycle_Homo sapiens_hsa047212.78016471
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74223114
5Circadian entrainment_Homo sapiens_hsa047132.66062423
6Olfactory transduction_Homo sapiens_hsa047402.58806838
7GABAergic synapse_Homo sapiens_hsa047272.56133774
8* Glutamatergic synapse_Homo sapiens_hsa047242.48313968
9Morphine addiction_Homo sapiens_hsa050322.44198628
10* Amphetamine addiction_Homo sapiens_hsa050312.40710720
11* Dopaminergic synapse_Homo sapiens_hsa047282.20077666
12Salivary secretion_Homo sapiens_hsa049702.18969411
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15014516
14Gastric acid secretion_Homo sapiens_hsa049711.92816037
15Long-term depression_Homo sapiens_hsa047301.87386387
16Cholinergic synapse_Homo sapiens_hsa047251.87179883
17Insulin secretion_Homo sapiens_hsa049111.85839973
18* Renin secretion_Homo sapiens_hsa049241.83632996
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80069667
20* Oxytocin signaling pathway_Homo sapiens_hsa049211.77669241
21Taste transduction_Homo sapiens_hsa047421.76511238
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71648431
23Serotonergic synapse_Homo sapiens_hsa047261.70991404
24GnRH signaling pathway_Homo sapiens_hsa049121.59066872
25* Calcium signaling pathway_Homo sapiens_hsa040201.58195000
26Cocaine addiction_Homo sapiens_hsa050301.50120975
27Gap junction_Homo sapiens_hsa045401.45665602
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37436580
29Collecting duct acid secretion_Homo sapiens_hsa049661.35424319
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34559536
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33869453
32Estrogen signaling pathway_Homo sapiens_hsa049151.28288795
33Glioma_Homo sapiens_hsa052141.26642994
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26478567
35cAMP signaling pathway_Homo sapiens_hsa040241.24589849
36* Axon guidance_Homo sapiens_hsa043601.17475037
37Cardiac muscle contraction_Homo sapiens_hsa042601.14865299
38Melanogenesis_Homo sapiens_hsa049161.14832697
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13350399
40Type II diabetes mellitus_Homo sapiens_hsa049301.12850685
41* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11776119
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08964494
43ErbB signaling pathway_Homo sapiens_hsa040121.07166540
44Phototransduction_Homo sapiens_hsa047441.00516727
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.96649829
46* Oocyte meiosis_Homo sapiens_hsa041140.95542024
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94375847
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91174157
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90457654
50Dorso-ventral axis formation_Homo sapiens_hsa043200.89904286
51Pancreatic secretion_Homo sapiens_hsa049720.87172834
52Vibrio cholerae infection_Homo sapiens_hsa051100.86437243
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83978726
54Dilated cardiomyopathy_Homo sapiens_hsa054140.81613657
55Choline metabolism in cancer_Homo sapiens_hsa052310.79711951
56AMPK signaling pathway_Homo sapiens_hsa041520.79467130
57Thyroid hormone synthesis_Homo sapiens_hsa049180.77431737
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.77311067
59* VEGF signaling pathway_Homo sapiens_hsa043700.74437564
60* MAPK signaling pathway_Homo sapiens_hsa040100.74065462
61Alzheimers disease_Homo sapiens_hsa050100.73462851
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72208066
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.71630637
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71277369
65* Glucagon signaling pathway_Homo sapiens_hsa049220.67158332
66mTOR signaling pathway_Homo sapiens_hsa041500.65093390
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61558553
68Tight junction_Homo sapiens_hsa045300.61273845
69Ras signaling pathway_Homo sapiens_hsa040140.60216194
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59173030
71Rap1 signaling pathway_Homo sapiens_hsa040150.59012054
72Renal cell carcinoma_Homo sapiens_hsa052110.58589001
73* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58346581
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.58252485
75Non-small cell lung cancer_Homo sapiens_hsa052230.57414983
76Focal adhesion_Homo sapiens_hsa045100.56427673
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55396154
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55279085
79Alcoholism_Homo sapiens_hsa050340.54927012
80Endometrial cancer_Homo sapiens_hsa052130.54519742
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53106581
82Insulin signaling pathway_Homo sapiens_hsa049100.52928600
83African trypanosomiasis_Homo sapiens_hsa051430.52454133
84Arginine and proline metabolism_Homo sapiens_hsa003300.49108022
85Prolactin signaling pathway_Homo sapiens_hsa049170.48781550
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48204047
87Amoebiasis_Homo sapiens_hsa051460.47693849
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47473006
89Colorectal cancer_Homo sapiens_hsa052100.46738115
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46598216
91Insulin resistance_Homo sapiens_hsa049310.46104176
92Oxidative phosphorylation_Homo sapiens_hsa001900.45870235
93* Wnt signaling pathway_Homo sapiens_hsa043100.45774280
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44883726
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44732399
96Type I diabetes mellitus_Homo sapiens_hsa049400.44257915
97Inositol phosphate metabolism_Homo sapiens_hsa005620.43849931
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43509172
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.42275107
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42216418
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42204471
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40608157
103Arginine biosynthesis_Homo sapiens_hsa002200.40347275
104Prion diseases_Homo sapiens_hsa050200.39748498
105Vitamin B6 metabolism_Homo sapiens_hsa007500.39511045
106Parkinsons disease_Homo sapiens_hsa050120.39269325
107Circadian rhythm_Homo sapiens_hsa047100.39266574
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36053601
109Platelet activation_Homo sapiens_hsa046110.35469079
110Endocytosis_Homo sapiens_hsa041440.35416639
111FoxO signaling pathway_Homo sapiens_hsa040680.35234562
112Chemokine signaling pathway_Homo sapiens_hsa040620.34637965
113* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33421610
114Regulation of autophagy_Homo sapiens_hsa041400.31941125
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27953041
116Bile secretion_Homo sapiens_hsa049760.26725008
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26505976

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