PPP2R5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.28511017
2daunorubicin metabolic process (GO:0044597)7.28511017
3polyketide metabolic process (GO:0030638)7.28511017
4protein localization to kinetochore (GO:0034501)4.91578618
5mitotic sister chromatid segregation (GO:0000070)4.88819221
6interferon-gamma production (GO:0032609)4.47784497
7protein localization to chromosome, centromeric region (GO:0071459)4.44870298
8sister chromatid segregation (GO:0000819)4.33781423
9mitotic chromosome condensation (GO:0007076)4.25438494
10aminoglycoside antibiotic metabolic process (GO:0030647)4.24927680
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.10399866
12negative regulation of phagocytosis (GO:0050765)4.06977997
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.04272375
14negative regulation of execution phase of apoptosis (GO:1900118)3.99134611
15regulation of cilium movement (GO:0003352)3.96717918
16negative regulation of cell cycle G2/M phase transition (GO:1902750)3.93585361
17regulation of mammary gland epithelial cell proliferation (GO:0033599)3.92468667
18DNA replication-dependent nucleosome organization (GO:0034723)3.88874311
19DNA replication-dependent nucleosome assembly (GO:0006335)3.88874311
20positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.87672019
21regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.87672019
22positive regulation of mRNA catabolic process (GO:0061014)3.79988724
23regulation of telomere maintenance via telomerase (GO:0032210)3.79818206
24synapsis (GO:0007129)3.73196863
25DNA deamination (GO:0045006)3.72909015
26nuclear pore complex assembly (GO:0051292)3.69223985
27positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.66654365
28regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.66654365
29regulation of translation in response to stress (GO:0043555)3.57351107
30positive regulation of granulocyte differentiation (GO:0030854)3.51980606
31cellular response to interleukin-15 (GO:0071350)3.51101780
32activated T cell proliferation (GO:0050798)3.45592831
33histone H2A acetylation (GO:0043968)3.44631617
34negative regulation of telomere maintenance (GO:0032205)3.41607864
35acrosome assembly (GO:0001675)3.39074112
36maintenance of protein location in nucleus (GO:0051457)3.38652437
37protein K11-linked deubiquitination (GO:0035871)3.37284160
38positive regulation of histone H3-K4 methylation (GO:0051571)3.31579728
39fusion of sperm to egg plasma membrane (GO:0007342)3.30671007
40response to interleukin-15 (GO:0070672)3.28747808
41chromosome condensation (GO:0030261)3.28665102
42regulation of regulatory T cell differentiation (GO:0045589)3.24822072
43keratinocyte development (GO:0003334)3.22843192
44pore complex assembly (GO:0046931)3.22559796
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.22555699
46lactate metabolic process (GO:0006089)3.22425049
47negative regulation of telomerase activity (GO:0051974)3.21659476
48signal peptide processing (GO:0006465)3.21308261
49regulation of mRNA catabolic process (GO:0061013)3.19805385
50DNA double-strand break processing (GO:0000729)3.18408209
51prenylation (GO:0097354)3.16833054
52protein prenylation (GO:0018342)3.16833054
53DNA packaging (GO:0006323)3.16604853
54DNA replication checkpoint (GO:0000076)3.14659678
55nuclear pore organization (GO:0006999)3.12818807
56protein K6-linked ubiquitination (GO:0085020)3.10436023
57regulation of glucokinase activity (GO:0033131)3.09012792
58regulation of hexokinase activity (GO:1903299)3.09012792
59negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.07429450
60cullin deneddylation (GO:0010388)3.06439749
61regulation of memory T cell differentiation (GO:0043380)3.02180111
62attachment of spindle microtubules to kinetochore (GO:0008608)3.01934159
63sequestering of actin monomers (GO:0042989)2.98867204
64mast cell activation (GO:0045576)2.97069336
65intra-S DNA damage checkpoint (GO:0031573)2.97044190
66positive regulation of mRNA 3-end processing (GO:0031442)2.96411219
67regulation of response to osmotic stress (GO:0047484)2.94891939
68inositol phosphate catabolic process (GO:0071545)2.94009777
69negative regulation of cell killing (GO:0031342)2.93103353
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93103353
71megakaryocyte development (GO:0035855)2.93038912
72monoubiquitinated protein deubiquitination (GO:0035520)2.90360878
73respiratory chain complex IV assembly (GO:0008535)2.90138754
74establishment of chromosome localization (GO:0051303)2.89801571
75positive regulation of mRNA metabolic process (GO:1903313)2.89337050
76regulation of protein glycosylation (GO:0060049)2.89087917
77cellular ketone body metabolic process (GO:0046950)2.88457766
78cilium or flagellum-dependent cell motility (GO:0001539)2.87691011
79regulation of gamma-delta T cell differentiation (GO:0045586)2.86944691
80neural tube formation (GO:0001841)2.86702758
81regulation of mRNA 3-end processing (GO:0031440)2.86041716
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85934707
83positive regulation of protein autophosphorylation (GO:0031954)2.85643260
84regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.85193296
85histone H4-K5 acetylation (GO:0043981)2.83069340
86histone H4-K8 acetylation (GO:0043982)2.83069340
87regulation of MHC class I biosynthetic process (GO:0045343)2.82681869
88histone mRNA catabolic process (GO:0071044)2.81418301
89protein deneddylation (GO:0000338)2.81370179
90cytidine metabolic process (GO:0046087)2.80745550
91cytidine catabolic process (GO:0006216)2.80745550
92cytidine deamination (GO:0009972)2.80745550
93negative regulation of DNA-dependent DNA replication (GO:2000104)2.80197571
94leukocyte aggregation (GO:0070486)2.80117537
95DNA unwinding involved in DNA replication (GO:0006268)2.79843899
96positive T cell selection (GO:0043368)2.79013023
97regulation of B cell receptor signaling pathway (GO:0050855)2.78585972
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.78239646
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77679224
100cytochrome complex assembly (GO:0017004)2.77311228
101positive regulation of mRNA processing (GO:0050685)2.76696576
102ketone body metabolic process (GO:1902224)2.76020801
103positive regulation of protein deacetylation (GO:0090312)2.75838714
104resolution of meiotic recombination intermediates (GO:0000712)2.74297603
105DNA conformation change (GO:0071103)2.73954888
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72755069
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72755069
108positive regulation of mitotic sister chromatid separation (GO:1901970)2.72755069
109positive regulation of DNA-dependent DNA replication (GO:2000105)2.72160399
110multicellular organism reproduction (GO:0032504)2.71590905
111positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71402351
112rRNA transcription (GO:0009303)2.70860796
113RNA destabilization (GO:0050779)2.70383598
114protein targeting to Golgi (GO:0000042)2.69766367
115establishment of protein localization to Golgi (GO:0072600)2.69663152
116regulation of telomere maintenance (GO:0032204)2.69284786
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68252318
118negative regulation of DNA recombination (GO:0045910)2.68095052
119DNA duplex unwinding (GO:0032508)2.66781958
120negative T cell selection (GO:0043383)2.66269863
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65054796
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63437607
123DNA geometric change (GO:0032392)2.63183307
124mast cell degranulation (GO:0043303)2.63019754
125mast cell activation involved in immune response (GO:0002279)2.63019754
126double-strand break repair via homologous recombination (GO:0000724)2.62485407
127succinate metabolic process (GO:0006105)2.62374158
128positive regulation of protein import into nucleus, translocation (GO:0033160)2.62281589
129recombinational repair (GO:0000725)2.61657165
130negative regulation of necroptotic process (GO:0060546)2.60777580
131pyrimidine ribonucleoside catabolic process (GO:0046133)2.59105205
132positive regulation of gamma-delta T cell activation (GO:0046645)2.58988871
133chromatin assembly (GO:0031497)2.58270012
134valine metabolic process (GO:0006573)2.58140007
135mitotic metaphase plate congression (GO:0007080)2.58022824
136centriole replication (GO:0007099)2.57911147
137chromosome segregation (GO:0007059)2.57248861
138negative thymic T cell selection (GO:0045060)2.57209642
139mitotic sister chromatid cohesion (GO:0007064)2.56770332
140replication fork processing (GO:0031297)2.55938808
141DNA ligation (GO:0006266)2.55018329
142positive regulation of glycolytic process (GO:0045821)2.54688478
143mitotic G2/M transition checkpoint (GO:0044818)2.54280729
144axoneme assembly (GO:0035082)2.51420164
145CENP-A containing nucleosome assembly (GO:0034080)2.51040542
146retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49918403
147regulation of alpha-beta T cell proliferation (GO:0046640)2.49621849
148microtubule severing (GO:0051013)2.49471989
149negative regulation of epidermis development (GO:0045683)2.49260605
150negative regulation of cAMP-mediated signaling (GO:0043951)2.48901950
151T cell migration (GO:0072678)2.48349891
152rRNA methylation (GO:0031167)2.48158891
153regulation of necroptotic process (GO:0060544)2.48065935
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47817410
155DNA replication-independent nucleosome organization (GO:0034724)2.47203815
156DNA replication-independent nucleosome assembly (GO:0006336)2.47203815
157hepatocyte apoptotic process (GO:0097284)2.47088896
158negative regulation of protein oligomerization (GO:0032460)2.45987999
159protein localization to chromosome (GO:0034502)2.45856468
160protein polyglutamylation (GO:0018095)2.44663651
161sperm-egg recognition (GO:0035036)2.44526298
162histone H4-K12 acetylation (GO:0043983)2.43534265
163mitotic nuclear envelope disassembly (GO:0007077)2.43209226
164microtubule depolymerization (GO:0007019)2.42766278
165heart process (GO:0003015)2.41874881
166heart contraction (GO:0060047)2.41874881
167S-adenosylmethionine metabolic process (GO:0046500)2.40599756
168somite rostral/caudal axis specification (GO:0032525)2.40369545
169chromatin remodeling at centromere (GO:0031055)2.40344581
170plasma membrane fusion (GO:0045026)2.38031870
171mitotic recombination (GO:0006312)2.37950469
172polyol catabolic process (GO:0046174)2.37421873
173regulation of isotype switching to IgG isotypes (GO:0048302)2.37198559
174histone exchange (GO:0043486)2.36594043
175establishment of endothelial barrier (GO:0061028)2.35823645
176regulation of microtubule-based movement (GO:0060632)2.35808919
177regulation of gamma-delta T cell activation (GO:0046643)2.35546784
178rRNA catabolic process (GO:0016075)2.35381252
179intra-Golgi vesicle-mediated transport (GO:0006891)2.34895782
180metaphase plate congression (GO:0051310)2.34808135
181regulation of fibroblast apoptotic process (GO:2000269)2.34684857
182regulation of DNA endoreduplication (GO:0032875)2.33840438
183somatic hypermutation of immunoglobulin genes (GO:0016446)2.32981399
184positive regulation of natural killer cell mediated immunity (GO:0002717)2.29532877
185positive regulation of B cell differentiation (GO:0045579)2.28735957
186endocrine pancreas development (GO:0031018)2.28355164
187phosphorylated carbohydrate dephosphorylation (GO:0046838)2.28091080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05693364
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.71861134
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.32726975
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.03388970
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.88366251
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67476329
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.59497561
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.05727757
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.05727757
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.05727757
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.00027511
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96153864
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95728359
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81543290
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57441693
16ZNF274_21170338_ChIP-Seq_K562_Hela2.36926580
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.35999539
18VDR_22108803_ChIP-Seq_LS180_Human2.33311742
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28005699
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20318758
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15834601
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.06599654
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04143383
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00935376
25EWS_26573619_Chip-Seq_HEK293_Human1.95836549
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95157508
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94310137
28SCL_19346495_ChIP-Seq_HPC-7_Human1.92821100
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91160862
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90719647
31IGF1R_20145208_ChIP-Seq_DFB_Human1.85289021
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.83665830
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83039398
34FUS_26573619_Chip-Seq_HEK293_Human1.78982922
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.76200557
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75480084
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75297374
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72305997
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.72187544
40* EST1_17652178_ChIP-ChIP_JURKAT_Human1.71138312
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70692862
42TAF15_26573619_Chip-Seq_HEK293_Human1.70672753
43* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.69253432
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.69013625
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68967272
46* ER_23166858_ChIP-Seq_MCF-7_Human1.68866243
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64789443
48MYB_26560356_Chip-Seq_TH2_Human1.64146392
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62620912
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59809989
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59610194
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.55004604
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54730298
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52480267
55GBX2_23144817_ChIP-Seq_PC3_Human1.52432243
56* SPI1_23547873_ChIP-Seq_NB4_Human1.51428934
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51124674
58FOXP3_21729870_ChIP-Seq_TREG_Human1.48084795
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46794800
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46462161
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46299168
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44984075
63ELK1_19687146_ChIP-ChIP_HELA_Human1.43916363
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43719580
65MYB_26560356_Chip-Seq_TH1_Human1.43251292
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42503017
67P300_19829295_ChIP-Seq_ESCs_Human1.41654309
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40100766
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39041276
70* MYC_22102868_ChIP-Seq_BL_Human1.36370470
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.34710749
72VDR_23849224_ChIP-Seq_CD4+_Human1.33444905
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.33122015
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33014596
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32857996
76P53_22387025_ChIP-Seq_ESCs_Mouse1.31259522
77GATA3_26560356_Chip-Seq_TH2_Human1.30937620
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30563793
79RUNX_20019798_ChIP-Seq_JUKART_Human1.30353474
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.29701560
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29384777
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.29312392
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28897081
84* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27766534
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26753083
86IRF1_19129219_ChIP-ChIP_H3396_Human1.26544995
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25893308
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25846729
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24782397
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24770773
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22807579
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22596936
93STAT3_23295773_ChIP-Seq_U87_Human1.21269094
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.19757986
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19431405
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19068849
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18679708
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.18615200
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18455960
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.18358108
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17930210
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17858324
103BCAT_22108803_ChIP-Seq_LS180_Human1.17817745
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17769849
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17105021
106SMAD4_21799915_ChIP-Seq_A2780_Human1.17077816
107P300_18555785_Chip-Seq_ESCs_Mouse1.16502364
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16493777
109TP53_22573176_ChIP-Seq_HFKS_Human1.16414777
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.16263228
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16227220
112* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16165976
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15805607
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.15485903
115* SALL4_22934838_ChIP-ChIP_CD34+_Human1.13282682
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12959278
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.12522060
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.11739577
119IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11697825
120SOX2_19829295_ChIP-Seq_ESCs_Human1.10832841
121NANOG_19829295_ChIP-Seq_ESCs_Human1.10832841
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10388052
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10272857
124AR_21909140_ChIP-Seq_LNCAP_Human1.10187099
125* SRF_21415370_ChIP-Seq_HL-1_Mouse1.10166790
126* TCF4_23295773_ChIP-Seq_U87_Human1.09855642
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.09811935
128NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08880469
129CIITA_25753668_ChIP-Seq_RAJI_Human1.07697550
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07589738
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07470939
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07318060
133CTCF_18555785_Chip-Seq_ESCs_Mouse1.06465997
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05728861
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05597150
136E2F1_21310950_ChIP-Seq_MCF-7_Human1.05478362
137CBP_20019798_ChIP-Seq_JUKART_Human1.05085518
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05085518
139* MAF_26560356_Chip-Seq_TH1_Human1.03437540
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.01576742
141CDX2_22108803_ChIP-Seq_LS180_Human1.01442946
142* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00817241
143IRF8_27001747_Chip-Seq_BMDM_Mouse1.00101536
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99515180
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98362172
146* GABP_17652178_ChIP-ChIP_JURKAT_Human0.97263526
147POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97129506
148YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96570698
149* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95824719
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95604598
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94891728
152ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94808875
153SPI1_23127762_ChIP-Seq_K562_Human0.94773655
154UTX_26944678_Chip-Seq_JUKART_Human0.93761555
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93660605
156TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93106143
157* GATA3_27048872_Chip-Seq_THYMUS_Human0.91332389
158* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91078409
159TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90582943
160SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90137905
161* TCF7_22412390_ChIP-Seq_EML_Mouse0.88764251
162MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88716055
163HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87069933
164NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86676426
165STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86212583
166ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83966570
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82261191
168ETS1_20019798_ChIP-Seq_JURKAT_Human0.82086015
169* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81504887
170TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80671633
171* KDM5A_27292631_Chip-Seq_BREAST_Human0.80600507
172NOTCH1_21737748_ChIP-Seq_TLL_Human0.80043980
173XRN2_22483619_ChIP-Seq_HELA_Human0.79157806
174* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78474742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.92747292
2MP0002396_abnormal_hematopoietic_system3.18168908
3MP0006292_abnormal_olfactory_placode2.92488775
4MP0005410_abnormal_fertilization2.90733227
5MP0005075_abnormal_melanosome_morpholog2.78801313
6MP0000372_irregular_coat_pigmentation2.63273123
7MP0010094_abnormal_chromosome_stability2.57014714
8MP0004957_abnormal_blastocyst_morpholog2.55052698
9MP0001835_abnormal_antigen_presentation2.50111101
10MP0008995_early_reproductive_senescence2.44254968
11MP0004264_abnormal_extraembryonic_tissu2.44215359
12MP0005671_abnormal_response_to2.40793226
13MP0002102_abnormal_ear_morphology2.40464540
14MP0010234_abnormal_vibrissa_follicle2.38995918
15MP0003077_abnormal_cell_cycle2.36721289
16MP0008007_abnormal_cellular_replicative2.27199880
17MP0002837_dystrophic_cardiac_calcinosis2.18868717
18MP0003763_abnormal_thymus_physiology2.18458959
19MP0003111_abnormal_nucleus_morphology2.07033694
20MP0002163_abnormal_gland_morphology2.05295838
21MP0003890_abnormal_embryonic-extraembry1.98268880
22MP0005379_endocrine/exocrine_gland_phen1.95616858
23MP0003123_paternal_imprinting1.90711928
24MP0003121_genomic_imprinting1.88016550
25MP0002693_abnormal_pancreas_physiology1.80723861
26MP0006072_abnormal_retinal_apoptosis1.74186597
27MP0002638_abnormal_pupillary_reflex1.71925158
28MP0002398_abnormal_bone_marrow1.68248372
29MP0000427_abnormal_hair_cycle1.64118236
30MP0003195_calcinosis1.58016039
31MP0003693_abnormal_embryo_hatching1.57582578
32MP0002420_abnormal_adaptive_immunity1.55478206
33MP0005645_abnormal_hypothalamus_physiol1.54337174
34MP0001800_abnormal_humoral_immune1.52652470
35MP0001819_abnormal_immune_cell1.52378031
36MP0009785_altered_susceptibility_to1.51975429
37MP0004808_abnormal_hematopoietic_stem1.48401362
38MP0005000_abnormal_immune_tolerance1.44827846
39MP0005253_abnormal_eye_physiology1.44037972
40MP0000703_abnormal_thymus_morphology1.41911264
41MP0005394_taste/olfaction_phenotype1.41580689
42MP0005499_abnormal_olfactory_system1.41580689
43MP0008058_abnormal_DNA_repair1.41180677
44MP0002928_abnormal_bile_duct1.41004780
45MP0000749_muscle_degeneration1.39852461
46MP0003122_maternal_imprinting1.38704061
47MP0004147_increased_porphyrin_level1.38469134
48MP0000689_abnormal_spleen_morphology1.37661402
49MP0002722_abnormal_immune_system1.37097189
50MP0001984_abnormal_olfaction1.37093100
51MP0002405_respiratory_system_inflammati1.36336781
52MP0002452_abnormal_antigen_presenting1.35466732
53MP0006082_CNS_inflammation1.34706679
54MP0000716_abnormal_immune_system1.33328444
55MP0000350_abnormal_cell_proliferation1.33121283
56MP0009333_abnormal_splenocyte_physiolog1.32383226
57MP0002909_abnormal_adrenal_gland1.32315247
58MP0001873_stomach_inflammation1.30384167
59MP0004043_abnormal_pH_regulation1.29265715
60MP0000490_abnormal_crypts_of1.29258484
61MP0009780_abnormal_chondrocyte_physiolo1.27132701
62MP0006036_abnormal_mitochondrial_physio1.26568413
63MP0003787_abnormal_imprinting1.26473376
64MP0003183_abnormal_peptide_metabolism1.24798633
65MP0002723_abnormal_immune_serum1.24683564
66MP0003880_abnormal_central_pattern1.24474239
67MP0002653_abnormal_ependyma_morphology1.23622281
68MP0002429_abnormal_blood_cell1.23614398
69MP0001672_abnormal_embryogenesis/_devel1.22557726
70MP0005380_embryogenesis_phenotype1.22557726
71MP0002877_abnormal_melanocyte_morpholog1.21000434
72MP0001944_abnormal_pancreas_morphology1.18378754
73MP0002009_preneoplasia1.17775396
74MP0005408_hypopigmentation1.17467251
75MP0004381_abnormal_hair_follicle1.16738476
76MP0006054_spinal_hemorrhage1.16511989
77MP0005025_abnormal_response_to1.16236779
78MP0003011_delayed_dark_adaptation1.14116258
79MP0002127_abnormal_cardiovascular_syste1.13805489
80MP0003984_embryonic_growth_retardation1.13585859
81MP0001986_abnormal_taste_sensitivity1.13522608
82MP0002148_abnormal_hypersensitivity_rea1.13035048
83MP0005551_abnormal_eye_electrophysiolog1.12751394
84MP0000343_altered_response_to1.11587557
85MP0000313_abnormal_cell_death1.11041939
86MP0002088_abnormal_embryonic_growth/wei1.10837464
87MP0002166_altered_tumor_susceptibility1.08782291
88MP0008932_abnormal_embryonic_tissue1.08141451
89MP0005174_abnormal_tail_pigmentation1.07938318
90MP0010352_gastrointestinal_tract_polyps1.07462460
91MP0008877_abnormal_DNA_methylation1.07356470
92MP0002006_tumorigenesis1.06024154
93MP0003448_altered_tumor_morphology1.05448915
94MP0005310_abnormal_salivary_gland1.04205165
95MP0002876_abnormal_thyroid_physiology1.02540872
96MP0001929_abnormal_gametogenesis1.02492140
97MP0001919_abnormal_reproductive_system1.01419712
98MP0000569_abnormal_digit_pigmentation1.01042198
99MP0000858_altered_metastatic_potential1.00974882
100MP0003436_decreased_susceptibility_to1.00684449
101MP0000685_abnormal_immune_system0.99600250
102MP0003646_muscle_fatigue0.97099906
103MP0002019_abnormal_tumor_incidence0.97072591
104MP0008872_abnormal_physiological_respon0.96133210
105MP0004484_altered_response_of0.96072071
106MP0003698_abnormal_male_reproductive0.95886617
107MP0001730_embryonic_growth_arrest0.95266237
108MP0003786_premature_aging0.94694478
109MP0002332_abnormal_exercise_endurance0.94432794
110MP0004084_abnormal_cardiac_muscle0.93547948
111MP0003656_abnormal_erythrocyte_physiolo0.92069008
112MP0005084_abnormal_gallbladder_morpholo0.91938617
113MP0002419_abnormal_innate_immunity0.90672842
114MP0005387_immune_system_phenotype0.90511747
115MP0001790_abnormal_immune_system0.90511747
116MP0002090_abnormal_vision0.90015964
117MP0005248_abnormal_Harderian_gland0.89585409
118MP0000015_abnormal_ear_pigmentation0.89012608
119MP0003172_abnormal_lysosome_physiology0.88681232
120MP0005636_abnormal_mineral_homeostasis0.88081141
121MP0005389_reproductive_system_phenotype0.87609473
122MP0005623_abnormal_meninges_morphology0.87576474
123MP0002086_abnormal_extraembryonic_tissu0.87140817
124MP0001764_abnormal_homeostasis0.86549496
125MP0001697_abnormal_embryo_size0.86232665
126MP0003866_abnormal_defecation0.85996467
127MP0003828_pulmonary_edema0.84812894
128MP0006035_abnormal_mitochondrial_morpho0.84266727
129MP0002078_abnormal_glucose_homeostasis0.82852039
130MP0004142_abnormal_muscle_tone0.82151928
131MP0002277_abnormal_respiratory_mucosa0.82055905
132MP0000516_abnormal_urinary_system0.80814654
133MP0005367_renal/urinary_system_phenotyp0.80814654
134MP0010155_abnormal_intestine_physiology0.80033183
135MP0001545_abnormal_hematopoietic_system0.79938120
136MP0005397_hematopoietic_system_phenotyp0.79938120
137MP0002254_reproductive_system_inflammat0.79909852
138MP0005646_abnormal_pituitary_gland0.79787566
139MP0000631_abnormal_neuroendocrine_gland0.79311176
140MP0010307_abnormal_tumor_latency0.78600382
141MP0001293_anophthalmia0.78592435
142MP0004858_abnormal_nervous_system0.77968657
143MP0003045_fibrosis0.76151193
144MP0002095_abnormal_skin_pigmentation0.75286008
145MP0004510_myositis0.74926200
146MP0003252_abnormal_bile_duct0.74522059
147MP0005266_abnormal_metabolism0.74167516
148MP0000653_abnormal_sex_gland0.74141497
149MP0002210_abnormal_sex_determination0.73003751
150MP0004215_abnormal_myocardial_fiber0.71368198
151MP0001845_abnormal_inflammatory_respons0.69226709
152MP0003950_abnormal_plasma_membrane0.69201256
153MP0002132_abnormal_respiratory_system0.69157619
154MP0009697_abnormal_copulation0.69043953
155MP0002080_prenatal_lethality0.68586771
156MP0002085_abnormal_embryonic_tissue0.68050980

Predicted human phenotypes

RankGene SetZ-score
1Nephroblastoma (Wilms tumor) (HP:0002667)4.17822824
2Bilateral microphthalmos (HP:0007633)4.06036433
3Embryonal renal neoplasm (HP:0011794)3.86667254
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60093495
5Chromsome breakage (HP:0040012)3.54631504
6Abnormal lung lobation (HP:0002101)3.53760983
7Thyroiditis (HP:0100646)3.40643949
8Amyotrophic lateral sclerosis (HP:0007354)3.34990066
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.33429836
10Hypochromic microcytic anemia (HP:0004840)3.31956922
11Combined immunodeficiency (HP:0005387)3.29821773
12Degeneration of anterior horn cells (HP:0002398)3.27143085
13Abnormality of the anterior horn cell (HP:0006802)3.27143085
14Nasal polyposis (HP:0100582)3.23553181
15Atrophy/Degeneration involving motor neurons (HP:0007373)3.12689326
16Stomatitis (HP:0010280)2.96757882
17Multiple enchondromatosis (HP:0005701)2.85986407
18Hepatoblastoma (HP:0002884)2.83783451
19Renal cortical cysts (HP:0000803)2.82984112
20Pancreatic cysts (HP:0001737)2.81556374
21Elevated erythrocyte sedimentation rate (HP:0003565)2.81206464
22Meckel diverticulum (HP:0002245)2.76084337
23Hypoproteinemia (HP:0003075)2.74384459
24Myositis (HP:0100614)2.73479200
25Ependymoma (HP:0002888)2.71242078
26Abnormality of the lower motor neuron (HP:0002366)2.71034326
27Recurrent abscess formation (HP:0002722)2.70783630
28Hypothermia (HP:0002045)2.70472371
29Ketoacidosis (HP:0001993)2.66768241
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.66152696
31Abnormality of the nasal mucosa (HP:0000433)2.65957692
32Recurrent bronchitis (HP:0002837)2.65117796
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.65088061
34Abnormality of the ileum (HP:0001549)2.60930320
35Neoplasm of the adrenal cortex (HP:0100641)2.57629330
36Abnormality of the renal cortex (HP:0011035)2.57332880
37Progressive macrocephaly (HP:0004481)2.57164832
38Rib fusion (HP:0000902)2.56047756
39Intestinal atresia (HP:0011100)2.54859454
40Orchitis (HP:0100796)2.54409822
41Absent frontal sinuses (HP:0002688)2.49765668
42T lymphocytopenia (HP:0005403)2.48607603
43Methylmalonic acidemia (HP:0002912)2.45636769
44Myelodysplasia (HP:0002863)2.45409924
45Abnormality of chromosome stability (HP:0003220)2.43680201
46Pancreatic fibrosis (HP:0100732)2.43485315
47Medial flaring of the eyebrow (HP:0010747)2.41335861
48Volvulus (HP:0002580)2.40643930
49Abnormality of chromosome segregation (HP:0002916)2.39736495
50Rhabdomyosarcoma (HP:0002859)2.39587923
51Hypoglycemic seizures (HP:0002173)2.37469421
52Abnormality of endocrine pancreas physiology (HP:0012093)2.37034584
53Abnormality of the pancreatic islet cells (HP:0006476)2.37034584
54Abnormality of T cell number (HP:0011839)2.36353873
55Autoimmune hemolytic anemia (HP:0001890)2.35444104
56IgG deficiency (HP:0004315)2.33400469
57Progressive inability to walk (HP:0002505)2.32013967
58Duodenal stenosis (HP:0100867)2.31639324
59Small intestinal stenosis (HP:0012848)2.31639324
60Absent/shortened dynein arms (HP:0200106)2.30945865
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.30945865
62Aplastic anemia (HP:0001915)2.30223639
63Abnormality of T cell physiology (HP:0011840)2.27949722
64Conjunctival hamartoma (HP:0100780)2.25040131
65Hamartoma of the eye (HP:0010568)2.24965314
66Large for gestational age (HP:0001520)2.24472161
67Abnormality of the prostate (HP:0008775)2.24274028
68Chronic diarrhea (HP:0002028)2.23680155
69Impulsivity (HP:0100710)2.22904569
70Gaze-evoked nystagmus (HP:0000640)2.19293619
71Abnormality of vitamin B metabolism (HP:0004340)2.18893120
72Rectal fistula (HP:0100590)2.18666824
73Rectovaginal fistula (HP:0000143)2.18666824
74True hermaphroditism (HP:0010459)2.18515451
75Intestinal fistula (HP:0100819)2.17824879
76Hyperinsulinemic hypoglycemia (HP:0000825)2.16457019
77Hematochezia (HP:0002573)2.14822005
78Cutaneous melanoma (HP:0012056)2.13913140
79Bronchitis (HP:0012387)2.11413439
80Abnormality of the preputium (HP:0100587)2.10944849
81Stomach cancer (HP:0012126)2.10263631
82Molar tooth sign on MRI (HP:0002419)2.06764527
83Abnormality of midbrain morphology (HP:0002418)2.06764527
84Supernumerary spleens (HP:0009799)2.06750264
85Hyperglycemia (HP:0003074)2.04768391
86Neoplasm of the adrenal gland (HP:0100631)2.04737252
87Papilledema (HP:0001085)2.04247449
8811 pairs of ribs (HP:0000878)2.04198780
89Medulloblastoma (HP:0002885)2.03210628
90Type I transferrin isoform profile (HP:0003642)2.01545092
91Agnosia (HP:0010524)2.00701109
92Acute necrotizing encephalopathy (HP:0006965)2.00286708
93Abnormality of the labia minora (HP:0012880)1.99105076
94Recurrent bacterial skin infections (HP:0005406)1.97886914
95Spinal muscular atrophy (HP:0007269)1.97578601
96Hypoglycemic coma (HP:0001325)1.97369449
97Cellulitis (HP:0100658)1.96928914
98Abnormality of the astrocytes (HP:0100707)1.96122827
99Astrocytoma (HP:0009592)1.96122827
100Neoplasm of striated muscle (HP:0009728)1.96111787
101Severe combined immunodeficiency (HP:0004430)1.96029149
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.95187027
103Sloping forehead (HP:0000340)1.92430559
104Bone marrow hypocellularity (HP:0005528)1.91655369
105Metaphyseal dysplasia (HP:0100255)1.91132371
106Increased IgM level (HP:0003496)1.91006501
107Fair hair (HP:0002286)1.90739004
108Hypomagnesemia (HP:0002917)1.90487455
109Eosinophilia (HP:0001880)1.90461621
110Recurrent viral infections (HP:0004429)1.90292050
111Congenital primary aphakia (HP:0007707)1.90198235
112Prominent metopic ridge (HP:0005487)1.89952059
113Abnormality of T cells (HP:0002843)1.89736322
114Neuroendocrine neoplasm (HP:0100634)1.89735208
115Abnormality of the fovea (HP:0000493)1.89193612
116Missing ribs (HP:0000921)1.87689791
117Breast carcinoma (HP:0003002)1.87076766
118Leukocytosis (HP:0001974)1.86013523
119Neuroblastic tumors (HP:0004376)1.84379809
120Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.84379809
121Neuroblastoma (HP:0003006)1.84379809
122Primitive neuroectodermal tumor (HP:0030065)1.84379809
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.83708720
124Hypoplasia of the fovea (HP:0007750)1.83708720
125Clubbing of toes (HP:0100760)1.83512272
126Nephrogenic diabetes insipidus (HP:0009806)1.82915527
127Embryonal neoplasm (HP:0002898)1.81281017
128Albinism (HP:0001022)1.81069908
129Abnormality of the pleura (HP:0002103)1.79836226
130Gait imbalance (HP:0002141)1.78788827
131Abnormality of the metopic suture (HP:0005556)1.76973540
132Duplicated collecting system (HP:0000081)1.76876861
133Oligodactyly (hands) (HP:0001180)1.76826327
134Pheochromocytoma (HP:0002666)1.76750511
135Generalized hypotonia (HP:0001290)1.76736554
136Angiofibromas (HP:0010615)1.76675853
137Adenoma sebaceum (HP:0009720)1.76675853
138Papillary thyroid carcinoma (HP:0002895)1.76554010
139Retrobulbar optic neuritis (HP:0100654)1.76109339
140Optic neuritis (HP:0100653)1.76109339
141B lymphocytopenia (HP:0010976)1.75594788
142Abnormality of B cell number (HP:0010975)1.75594788
143Generalized hypopigmentation of hair (HP:0011358)1.74574318
144Reduced antithrombin III activity (HP:0001976)1.74177437
145Furrowed tongue (HP:0000221)1.73936272
146Abnormality of the duodenum (HP:0002246)1.72814518
147Dislocated radial head (HP:0003083)1.71777988
148Nephronophthisis (HP:0000090)1.71440049
149Congenital stationary night blindness (HP:0007642)1.71302502
150Rhinitis (HP:0012384)1.71153806
151Pancreatic islet-cell hyperplasia (HP:0004510)1.70986448
152Abnormality of eosinophils (HP:0001879)1.70575221
153Aqueductal stenosis (HP:0002410)1.69831444
154Cystic hygroma (HP:0000476)1.69361362
155Attenuation of retinal blood vessels (HP:0007843)1.68660597
156Anomalous pulmonary venous return (HP:0010772)1.68349432
157Pulmonary infiltrates (HP:0002113)1.68194317
158Abnormal respiratory motile cilium physiology (HP:0012261)1.68153715
159Acute encephalopathy (HP:0006846)1.67583307
160Eczematoid dermatitis (HP:0000976)1.67196424
1613-Methylglutaconic aciduria (HP:0003535)1.66273011
162Ketosis (HP:0001946)1.64151090
163Abnormality of the vitamin B12 metabolism (HP:0004341)1.63457719
164Increased circulating renin level (HP:0000848)1.63182156
165Tongue fasciculations (HP:0001308)1.61984320
166Abnormality of the renal medulla (HP:0100957)1.61976330
167Lymphedema (HP:0001004)1.61820804
168Chronic mucocutaneous candidiasis (HP:0002728)1.61718843
169Recurrent cutaneous fungal infections (HP:0011370)1.61718843
170Panhypogammaglobulinemia (HP:0003139)1.61623028
171Neoplasm of the tracheobronchial system (HP:0100552)1.60291916
172Abnormality of the renal collecting system (HP:0004742)1.58740819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.35429779
2CDK124.04721272
3CSF1R3.15602536
4TXK3.02347857
5TRIM283.02073902
6NUAK13.01512914
7GRK62.94894607
8STK102.92584034
9GRK52.91024210
10MAP4K12.69317769
11TAOK32.44485873
12PDK32.40060414
13PDK42.40060414
14GRK72.33123542
15BUB12.32006390
16BRSK22.24659880
17TNIK2.05405974
18ADRBK22.02611776
19TTK1.98232882
20FGFR21.97994571
21NLK1.87973976
22TESK11.86961665
23MAP4K21.84740725
24CDC71.80914750
25CLK11.77631913
26BMPR21.76818452
27PRKD31.72114100
28MATK1.71325638
29TGFBR21.70016929
30GRK11.64187147
31BRSK11.63949513
32ITK1.63370071
33BMPR1B1.62840280
34WNK31.62337201
35MAP3K41.58376243
36WNK11.55952759
37PLK21.52729493
38KIT1.42240900
39PDK21.40563350
40ZAK1.40266867
41EIF2AK21.37522673
42MST41.35512190
43BCR1.33924151
44MAPK71.28569042
45ACVR1B1.28147529
46CAMKK21.27741025
47MKNK21.26705309
48NTRK11.25402297
49WEE11.23536820
50MARK31.23494135
51PAK31.22180588
52FLT31.21842911
53MAP3K141.21308956
54PASK1.20583126
55CDK71.17141393
56RIPK41.16658824
57STK41.16531118
58TESK21.16244101
59PLK11.13315728
60EIF2AK31.12990009
61AKT31.11235009
62MAPK131.10829233
63MAP3K21.09494544
64SRPK11.09410998
65ERN11.09377541
66NTRK31.08642659
67TRPM71.08380481
68ZAP701.08235038
69CCNB11.08179402
70CHEK21.07656812
71TEC1.07623825
72TYRO31.06776434
73TYK21.05508419
74FGFR31.04634747
75STK31.02225965
76STK241.01937519
77PINK11.00865398
78CSK0.98184517
79JAK10.96751986
80SIK30.92512114
81NEK20.90356726
82CHEK10.89298758
83PIM10.88011060
84SYK0.85733462
85ATR0.85716856
86BTK0.82212973
87LCK0.80344433
88MAP2K60.79045738
89IRAK40.77093878
90PLK40.76950863
91PIM20.76829681
92KSR10.76548822
93PLK30.74999798
94IRAK10.73823695
95HIPK20.72685547
96PRKG20.72137708
97MOS0.71967973
98MKNK10.71668377
99IKBKB0.70630882
100TNK20.70552580
101FER0.67233202
102JAK30.66662284
103RAF10.64351774
104PAK40.64263432
105ATM0.59741751
106PRPF4B0.58893966
107PRKCQ0.56653788
108CAMK40.56332291
109NEK10.56108786
110NEK60.55546935
111BLK0.53345310
112PIK3CG0.51910950
113CHUK0.49844118
114HCK0.49690236
115CDK180.48337049
116INSRR0.47914807
117AURKB0.47768054
118PRKCE0.46831077
119PHKG10.46774392
120PHKG20.46774392
121PRKCH0.45008213
122VRK10.44907510
123PRKCD0.43794981
124ADRBK10.43662184
125BRD40.43363270
126CDK20.43329581
127MAP3K120.43199158
128IKBKE0.43127180
129YES10.42713317
130JAK20.40705664
131PDK10.40244401
132FES0.40034072
133ERBB30.39939915
134RPS6KB10.39878465
135RPS6KA60.39651649
136CDK150.39600160
137RPS6KL10.39548792
138RPS6KC10.39548792
139PTK2B0.39136214
140OXSR10.37675621
141MELK0.37377143
142RPS6KA40.37317642
143LYN0.36159394
144MAPKAPK20.36063032
145TLK10.35845968
146EIF2AK10.35656511
147PRKAA20.35653710
148EPHA30.35074328
149NEK90.35071985
150STK390.34946619
151STK110.34513642
152CDK11A0.33913033
153CDK30.33572452
154SGK20.30193593
155CSNK1G10.30168983
156PRKCI0.28429964
157PIK3CA0.28358121

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.77486616
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.39334017
3Butanoate metabolism_Homo sapiens_hsa006502.59180481
4DNA replication_Homo sapiens_hsa030302.56551177
5Primary immunodeficiency_Homo sapiens_hsa053402.46425465
6Mismatch repair_Homo sapiens_hsa034302.39636649
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14346776
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08439160
9Homologous recombination_Homo sapiens_hsa034402.01415892
10Vitamin B6 metabolism_Homo sapiens_hsa007501.99855595
11Propanoate metabolism_Homo sapiens_hsa006401.96776614
12Base excision repair_Homo sapiens_hsa034101.95387724
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93553000
14Cell cycle_Homo sapiens_hsa041101.89595584
15Regulation of autophagy_Homo sapiens_hsa041401.82919304
16Fanconi anemia pathway_Homo sapiens_hsa034601.81665934
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76785877
18Non-homologous end-joining_Homo sapiens_hsa034501.70922345
19RNA transport_Homo sapiens_hsa030131.69511893
20T cell receptor signaling pathway_Homo sapiens_hsa046601.69044823
21RNA degradation_Homo sapiens_hsa030181.67800735
22Antigen processing and presentation_Homo sapiens_hsa046121.59020177
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54523082
24Spliceosome_Homo sapiens_hsa030401.40584271
25Nucleotide excision repair_Homo sapiens_hsa034201.38606085
26Circadian rhythm_Homo sapiens_hsa047101.37520711
27Basal transcription factors_Homo sapiens_hsa030221.36941264
28Viral myocarditis_Homo sapiens_hsa054161.34989166
29Measles_Homo sapiens_hsa051621.32841594
30Phototransduction_Homo sapiens_hsa047441.29920310
31B cell receptor signaling pathway_Homo sapiens_hsa046621.27467518
32* mRNA surveillance pathway_Homo sapiens_hsa030151.27030083
33Selenocompound metabolism_Homo sapiens_hsa004501.22771026
34Fructose and mannose metabolism_Homo sapiens_hsa000511.21725630
35Collecting duct acid secretion_Homo sapiens_hsa049661.18186580
36Oxidative phosphorylation_Homo sapiens_hsa001901.18100905
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.16615512
38Leishmaniasis_Homo sapiens_hsa051401.14671217
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14426563
40One carbon pool by folate_Homo sapiens_hsa006701.13840856
41Thyroid cancer_Homo sapiens_hsa052161.13103876
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11054746
43Arachidonic acid metabolism_Homo sapiens_hsa005901.11052890
44Graft-versus-host disease_Homo sapiens_hsa053321.10086636
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09791917
46Olfactory transduction_Homo sapiens_hsa047401.09388285
47Allograft rejection_Homo sapiens_hsa053301.07353535
48Insulin secretion_Homo sapiens_hsa049111.06772116
49Herpes simplex infection_Homo sapiens_hsa051681.06480619
50Hematopoietic cell lineage_Homo sapiens_hsa046401.05860222
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03854164
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01886363
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01638735
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00449579
55Type II diabetes mellitus_Homo sapiens_hsa049301.00446365
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.97325935
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.96317643
58p53 signaling pathway_Homo sapiens_hsa041150.95969817
59Galactose metabolism_Homo sapiens_hsa000520.92221620
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90057176
61Shigellosis_Homo sapiens_hsa051310.89997130
62Viral carcinogenesis_Homo sapiens_hsa052030.89797829
63Acute myeloid leukemia_Homo sapiens_hsa052210.89289811
64* Oocyte meiosis_Homo sapiens_hsa041140.88492015
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86220591
66HTLV-I infection_Homo sapiens_hsa051660.85725925
67Influenza A_Homo sapiens_hsa051640.85152139
68Legionellosis_Homo sapiens_hsa051340.85067361
69Apoptosis_Homo sapiens_hsa042100.84171413
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83496897
71Proteasome_Homo sapiens_hsa030500.83198511
72Fatty acid elongation_Homo sapiens_hsa000620.83182258
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82526636
74Non-small cell lung cancer_Homo sapiens_hsa052230.82190226
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81976194
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79905035
77Dorso-ventral axis formation_Homo sapiens_hsa043200.79654855
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.78867199
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78639465
80Platelet activation_Homo sapiens_hsa046110.77890148
81Pancreatic cancer_Homo sapiens_hsa052120.77767023
82Ether lipid metabolism_Homo sapiens_hsa005650.77170483
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76475071
84Toxoplasmosis_Homo sapiens_hsa051450.76250153
85Chemokine signaling pathway_Homo sapiens_hsa040620.74964833
86Peroxisome_Homo sapiens_hsa041460.74298261
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.74016802
88Epstein-Barr virus infection_Homo sapiens_hsa051690.71108285
89Nitrogen metabolism_Homo sapiens_hsa009100.69910415
90Protein export_Homo sapiens_hsa030600.69146724
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68715955
92FoxO signaling pathway_Homo sapiens_hsa040680.67598357
93RNA polymerase_Homo sapiens_hsa030200.66927721
94Ribosome_Homo sapiens_hsa030100.66314053
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66194345
96MicroRNAs in cancer_Homo sapiens_hsa052060.65117283
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64991490
98Amphetamine addiction_Homo sapiens_hsa050310.64870364
99Inositol phosphate metabolism_Homo sapiens_hsa005620.64670448
100Colorectal cancer_Homo sapiens_hsa052100.63909588
101mTOR signaling pathway_Homo sapiens_hsa041500.63468002
102Parkinsons disease_Homo sapiens_hsa050120.62521339
103Osteoclast differentiation_Homo sapiens_hsa043800.62377851
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61989169
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60524660
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60418781
107VEGF signaling pathway_Homo sapiens_hsa043700.60125087
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59278932
109Hepatitis B_Homo sapiens_hsa051610.57842817
110Autoimmune thyroid disease_Homo sapiens_hsa053200.57012758
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56856157
112Caffeine metabolism_Homo sapiens_hsa002320.56037273
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.56015184
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55910845
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55063061
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54498044
117Salmonella infection_Homo sapiens_hsa051320.53862210
118Type I diabetes mellitus_Homo sapiens_hsa049400.53580481
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52445715
120Pyrimidine metabolism_Homo sapiens_hsa002400.52338320
121Tuberculosis_Homo sapiens_hsa051520.52253896
122Chronic myeloid leukemia_Homo sapiens_hsa052200.51930768
123Endocytosis_Homo sapiens_hsa041440.49181907
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.49095730
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49092695
126Rap1 signaling pathway_Homo sapiens_hsa040150.48349788
127Pentose phosphate pathway_Homo sapiens_hsa000300.47647566
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47504672
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46604344
130Pathways in cancer_Homo sapiens_hsa052000.46588178
131Linoleic acid metabolism_Homo sapiens_hsa005910.46503822
132Purine metabolism_Homo sapiens_hsa002300.45481496
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45438253
134Prolactin signaling pathway_Homo sapiens_hsa049170.43566399
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43451461
136Endometrial cancer_Homo sapiens_hsa052130.43062932
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42616405
138Tryptophan metabolism_Homo sapiens_hsa003800.41333154
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40686202
140ABC transporters_Homo sapiens_hsa020100.39864085
141Taste transduction_Homo sapiens_hsa047420.37578421
142Fatty acid metabolism_Homo sapiens_hsa012120.36601713
143Morphine addiction_Homo sapiens_hsa050320.34184677
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33277975
145Folate biosynthesis_Homo sapiens_hsa007900.32799059
146Sulfur metabolism_Homo sapiens_hsa009200.30018778
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27041137
148Insulin resistance_Homo sapiens_hsa049310.26999443
149Steroid biosynthesis_Homo sapiens_hsa001000.26967280

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