PPP2R5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97264609
2regulation of sequestering of triglyceride (GO:0010889)4.96459711
3negative regulation of cell killing (GO:0031342)4.77162075
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77162075
5neutrophil activation involved in immune response (GO:0002283)4.59599705
6negative regulation of erythrocyte differentiation (GO:0045647)4.43711404
7positive regulation by symbiont of host defense response (GO:0052509)4.35167863
8modulation by symbiont of host defense response (GO:0052031)4.35167863
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.35167863
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.35167863
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.35167863
12modulation by symbiont of host immune response (GO:0052553)4.35167863
13antigen processing and presentation of endogenous antigen (GO:0019883)4.32750919
14detection of other organism (GO:0098543)4.27178810
15regulation of gamma-delta T cell differentiation (GO:0045586)4.05144900
16detection of bacterium (GO:0016045)4.05130595
17low-density lipoprotein particle clearance (GO:0034383)4.03721224
18regulation of B cell receptor signaling pathway (GO:0050855)3.96971284
19fatty acid transmembrane transport (GO:1902001)3.90002349
20detection of molecule of bacterial origin (GO:0032490)3.83811772
21detection of external biotic stimulus (GO:0098581)3.81681737
22response to peptidoglycan (GO:0032494)3.80354008
23negative regulation of granulocyte differentiation (GO:0030853)3.73974951
24macrophage activation involved in immune response (GO:0002281)3.71322619
25carnitine shuttle (GO:0006853)3.60741686
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.59781617
27cellular extravasation (GO:0045123)3.53378385
28biotin metabolic process (GO:0006768)3.52091098
29regulation of triglyceride catabolic process (GO:0010896)3.47898916
30phospholipid homeostasis (GO:0055091)3.46281692
31B cell receptor signaling pathway (GO:0050853)3.35011105
32leukocyte aggregation (GO:0070486)3.31644618
33valine metabolic process (GO:0006573)3.29521357
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29115321
35detection of biotic stimulus (GO:0009595)3.28803426
36positive regulation of fatty acid oxidation (GO:0046321)3.27699243
37neutrophil activation (GO:0042119)3.27003429
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26040075
39regulation of interferon-beta biosynthetic process (GO:0045357)3.25253795
40fatty acid beta-oxidation (GO:0006635)3.24128221
41urea cycle (GO:0000050)3.24090100
42urea metabolic process (GO:0019627)3.24090100
43negative regulation of lipase activity (GO:0060192)3.23978875
44acylglycerol homeostasis (GO:0055090)3.23659911
45triglyceride homeostasis (GO:0070328)3.23659911
46positive regulation of B cell differentiation (GO:0045579)3.23170485
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22283386
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.21873909
49plasma lipoprotein particle clearance (GO:0034381)3.21064546
50negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.19890509
51positive regulation of lipid catabolic process (GO:0050996)3.19384539
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.18465866
53complement activation, alternative pathway (GO:0006957)3.17987353
54brown fat cell differentiation (GO:0050873)3.15389643
55positive regulation of cellular amide metabolic process (GO:0034250)3.14616292
56response to host immune response (GO:0052572)3.14250218
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14250218
58triglyceride catabolic process (GO:0019433)3.13826479
59alpha-linolenic acid metabolic process (GO:0036109)3.11732722
60germinal center formation (GO:0002467)3.11662128
61regulation of cholesterol storage (GO:0010885)3.11275267
62response to interleukin-15 (GO:0070672)3.05787332
63fatty acid oxidation (GO:0019395)3.05099421
64lipid oxidation (GO:0034440)2.99676943
65granulocyte activation (GO:0036230)2.98660800
66neutral lipid catabolic process (GO:0046461)2.98429336
67acylglycerol catabolic process (GO:0046464)2.98429336
68positive regulation of gamma-delta T cell activation (GO:0046645)2.97702855
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96989018
70response to host (GO:0075136)2.96989018
71response to host defenses (GO:0052200)2.96989018
72lipid storage (GO:0019915)2.96518409
73negative regulation of protein autophosphorylation (GO:0031953)2.96242373
74L-phenylalanine catabolic process (GO:0006559)2.94701707
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94701707
76regulation of mast cell degranulation (GO:0043304)2.94369307
77white fat cell differentiation (GO:0050872)2.93904275
78indole-containing compound catabolic process (GO:0042436)2.92531573
79indolalkylamine catabolic process (GO:0046218)2.92531573
80tryptophan catabolic process (GO:0006569)2.92531573
81homocysteine metabolic process (GO:0050667)2.92191699
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90912801
83linoleic acid metabolic process (GO:0043651)2.90220784
84aromatic amino acid family catabolic process (GO:0009074)2.90146658
85nitrogen cycle metabolic process (GO:0071941)2.89474550
86immunoglobulin mediated immune response (GO:0016064)2.88538404
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88172010
88negative regulation of leukocyte mediated immunity (GO:0002704)2.86429496
89positive regulation of histone deacetylation (GO:0031065)2.86332170
90myeloid cell activation involved in immune response (GO:0002275)2.84100870
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83110313
92negative regulation of interleukin-12 production (GO:0032695)2.82705607
93leukocyte migration involved in inflammatory response (GO:0002523)2.81765547
94antigen processing and presentation via MHC class Ib (GO:0002475)2.81354558
95acetyl-CoA metabolic process (GO:0006084)2.81125337
96fatty acid catabolic process (GO:0009062)2.80749456
97embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79712664
98positive regulation of lipid storage (GO:0010884)2.79269887
99tryptophan metabolic process (GO:0006568)2.79245956
100positive regulation of granulocyte differentiation (GO:0030854)2.78761254
101negative regulation of lipid storage (GO:0010888)2.77548978
102carnitine transmembrane transport (GO:1902603)2.77489416
103regulation of leukocyte degranulation (GO:0043300)2.77392691
104positive regulation of cholesterol transport (GO:0032376)2.76819872
105positive regulation of sterol transport (GO:0032373)2.76819872
106regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75970812
107macrophage activation (GO:0042116)2.73145809
108negative regulation of T cell mediated immunity (GO:0002710)2.72698592
109positive regulation of cholesterol efflux (GO:0010875)2.72383522
110respiratory burst (GO:0045730)2.71332431
111regulation of B cell differentiation (GO:0045577)2.68403700
112positive thymic T cell selection (GO:0045059)2.68234619
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67989290
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66812053
115regulation of mast cell activation involved in immune response (GO:0033006)2.65964655
116microglial cell activation (GO:0001774)2.64279775
117regulation of triglyceride metabolic process (GO:0090207)2.64248360
118amino-acid betaine metabolic process (GO:0006577)2.62950260
119regulation of T-helper 2 cell differentiation (GO:0045628)2.62490000
120production of molecular mediator involved in inflammatory response (GO:0002532)2.61770235
121carnitine transport (GO:0015879)2.61227397
122amino-acid betaine transport (GO:0015838)2.61227397
123kynurenine metabolic process (GO:0070189)2.59869577
124phospholipid efflux (GO:0033700)2.59512469
125negative regulation of T-helper cell differentiation (GO:0045623)2.59480687
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59480687
127L-phenylalanine metabolic process (GO:0006558)2.58711084
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58711084
129negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57051218
130regulation of protein activation cascade (GO:2000257)2.56274025
131histone H3-K36 demethylation (GO:0070544)2.53314004
132short-chain fatty acid metabolic process (GO:0046459)2.51435023
133regulation of fatty acid beta-oxidation (GO:0031998)2.50935659
134regulation of bile acid biosynthetic process (GO:0070857)2.50552678
135leukocyte degranulation (GO:0043299)2.49083075
136response to muramyl dipeptide (GO:0032495)2.48725966
137growth hormone receptor signaling pathway (GO:0060396)2.48474967
138positive regulation of mast cell activation (GO:0033005)2.46616467
139definitive hemopoiesis (GO:0060216)2.45794168
140regulation of complement activation (GO:0030449)2.45188854
141peptidyl-glutamic acid carboxylation (GO:0017187)2.44857032
142protein carboxylation (GO:0018214)2.44857032
143regulation of fatty acid oxidation (GO:0046320)2.44463162
144regulation of granulocyte differentiation (GO:0030852)2.43693092
145intracellular lipid transport (GO:0032365)2.43635009
146cellular response to thyroid hormone stimulus (GO:0097067)2.42985917
147negative regulation of humoral immune response (GO:0002921)2.42825511
148acylglycerol biosynthetic process (GO:0046463)2.42296748
149neutral lipid biosynthetic process (GO:0046460)2.42296748
150interferon-gamma-mediated signaling pathway (GO:0060333)2.42152525
151positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.41784474
152monocarboxylic acid catabolic process (GO:0072329)2.41504555
153type I interferon signaling pathway (GO:0060337)2.41227559
154cellular response to type I interferon (GO:0071357)2.41227559
155fatty acid homeostasis (GO:0055089)2.40902585
156regulation of tolerance induction (GO:0002643)2.40593267
157histone H3-K4 trimethylation (GO:0080182)2.40449625
158plasma lipoprotein particle assembly (GO:0034377)2.39507842
159regulation of platelet aggregation (GO:0090330)2.39454957
160regulation of macrophage derived foam cell differentiation (GO:0010743)2.39180440
161response to type I interferon (GO:0034340)2.38908178
162B cell mediated immunity (GO:0019724)2.38895078
163regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.38411598
164lipid homeostasis (GO:0055088)2.38163259
165cellular response to interleukin-15 (GO:0071350)2.37930505
166regulation of necroptotic process (GO:0060544)2.37461233
167negative thymic T cell selection (GO:0045060)2.37443001
168G-protein coupled receptor internalization (GO:0002031)2.36537444
169embryonic process involved in female pregnancy (GO:0060136)2.36511536
170transcytosis (GO:0045056)2.35888624
171positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35588279
172regulation of regulated secretory pathway (GO:1903305)2.35535679
173triglyceride biosynthetic process (GO:0019432)2.35166103
174negative regulation of glycoprotein biosynthetic process (GO:0010561)2.35140200
175megakaryocyte development (GO:0035855)2.34846536
176regulation of alpha-beta T cell proliferation (GO:0046640)2.34091493
177antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33564868
178antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.33564868
179import into cell (GO:0098657)2.32077107
180regulation of lipid catabolic process (GO:0050994)2.32071154
181negative T cell selection (GO:0043383)2.31984293
182regulation of T cell tolerance induction (GO:0002664)2.31924729
183mannose metabolic process (GO:0006013)2.31875735
184positive regulation of triglyceride lipase activity (GO:0061365)2.31856992
185positive regulation of lipoprotein lipase activity (GO:0051006)2.31856992
186regulation of gamma-delta T cell activation (GO:0046643)2.31341237
187I-kappaB phosphorylation (GO:0007252)2.31088799
188negative regulation of complement activation (GO:0045916)2.30779605
189neutrophil mediated immunity (GO:0002446)2.30665840
190positive T cell selection (GO:0043368)2.30624057
191bile acid metabolic process (GO:0008206)2.29802906
192carnitine metabolic process (GO:0009437)2.29742526
193regulation of triglyceride biosynthetic process (GO:0010866)2.29250343
194cholesterol homeostasis (GO:0042632)2.28829974
195branched-chain amino acid metabolic process (GO:0009081)2.27335493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.37694407
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.32606213
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.08490604
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01402810
5MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88869632
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84635535
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.75044434
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.69836411
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.64664330
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44254000
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35472974
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.34348316
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31508431
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.25583930
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.16195069
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12960648
17SPI1_23127762_ChIP-Seq_K562_Human2.09038402
18VDR_24763502_ChIP-Seq_THP-1_Human2.07846666
19* SPI1_23547873_ChIP-Seq_NB4_Human2.04805338
20MYB_26560356_Chip-Seq_TH2_Human2.03059337
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02407029
22RUNX1_22412390_ChIP-Seq_EML_Mouse1.98558618
23MAF_26560356_Chip-Seq_TH1_Human1.96825754
24VDR_21846776_ChIP-Seq_THP-1_Human1.95202188
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.91512477
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88358479
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87886051
28TCF7_22412390_ChIP-Seq_EML_Mouse1.86456363
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83174639
30MYC_22102868_ChIP-Seq_BL_Human1.81324738
31MYB_26560356_Chip-Seq_TH1_Human1.80290568
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74208266
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71940211
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71756012
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70699117
36GATA1_22025678_ChIP-Seq_K562_Human1.70158994
37* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67700589
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67489828
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66552728
40GATA1_19941826_ChIP-Seq_K562_Human1.57384832
41GBX2_23144817_ChIP-Seq_PC3_Human1.57283371
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55428366
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55367988
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55347387
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50727328
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50562234
47UTX_26944678_Chip-Seq_JUKART_Human1.49446123
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47544129
49RUNX_20019798_ChIP-Seq_JUKART_Human1.46576997
50* NFE2_27457419_Chip-Seq_LIVER_Mouse1.45424905
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.43851436
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43090662
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41224533
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.39792913
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.39607623
56* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39402341
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38950614
58* GATA2_19941826_ChIP-Seq_K562_Human1.38016606
59KDM2B_26808549_Chip-Seq_DND41_Human1.37718550
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.37522013
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37240431
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36185769
63* PU_27001747_Chip-Seq_BMDM_Mouse1.35221750
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.34794988
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33890018
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32000845
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31439975
68* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31220380
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31174512
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31142010
71CLOCK_20551151_ChIP-Seq_293T_Human1.31123657
72GATA3_27048872_Chip-Seq_THYMUS_Human1.27297965
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26946254
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.26059380
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25981991
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.25848555
77MAF_26560356_Chip-Seq_TH2_Human1.25807684
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25394165
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25206911
80* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24876035
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23780306
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.23734713
83* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22332289
84* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20111311
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19707405
86VDR_24787735_ChIP-Seq_THP-1_Human1.19488342
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.19075439
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18770979
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17450143
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17295937
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16995588
92DROSHA_22980978_ChIP-Seq_HELA_Human1.16494495
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14935606
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14506391
95* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13427613
96* NCOR1_26117541_ChIP-Seq_K562_Human1.13343040
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13070421
98* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12726407
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10468477
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.10328389
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09759752
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08736146
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07735860
104TP53_16413492_ChIP-PET_HCT116_Human1.07568071
105* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07331351
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07193947
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05777943
108* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05771861
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04621330
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03433885
111* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03112370
112* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02283484
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01762854
114AHR_22903824_ChIP-Seq_MCF-7_Human1.01168316
115* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01069339
116* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00555792
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99181726
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99048457
119* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98457570
120* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98450063
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97797781
122BCAT_22108803_ChIP-Seq_LS180_Human0.97149541
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97131807
124* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96766662
125* P53_22387025_ChIP-Seq_ESCs_Mouse0.96652203
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95934903
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95896810
128* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95892028
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95803650
130* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95720630
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.95387506
132SCL_19346495_ChIP-Seq_HPC-7_Human0.94962307
133* RACK7_27058665_Chip-Seq_MCF-7_Human0.94847693
134* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94632290
135* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94632290
136* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94406422
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.94402830
138STAT3_23295773_ChIP-Seq_U87_Human0.94028344
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93986226
140* PU1_27457419_Chip-Seq_LIVER_Mouse0.93685813
141GATA3_26560356_Chip-Seq_TH2_Human0.93671192
142* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93192981
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93146487
144RXR_22108803_ChIP-Seq_LS180_Human0.92719545
145* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92665346
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92565595
147* CRX_20693478_ChIP-Seq_RETINA_Mouse0.92111974
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91736836
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.91297963
150* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91074503
151RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90658086
152* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90271798
153* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89908707
154* STAT3_18555785_Chip-Seq_ESCs_Mouse0.89845129
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.89577372
156* CMYC_18555785_Chip-Seq_ESCs_Mouse0.89151418
157* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88790956
158AR_21572438_ChIP-Seq_LNCaP_Human0.88122781
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86985525
160CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86897421
161* NMYC_18555785_Chip-Seq_ESCs_Mouse0.86720727
162ESR1_20079471_ChIP-ChIP_T-47D_Human0.86502730
163* ZFX_18555785_Chip-Seq_ESCs_Mouse0.85986130
164* P300_18555785_Chip-Seq_ESCs_Mouse0.85645232
165* TBL1_22424771_ChIP-Seq_293T_Human0.85114624
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84262087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.77436035
2MP0005360_urolithiasis3.97979863
3MP0002139_abnormal_hepatobiliary_system3.75864319
4MP0005365_abnormal_bile_salt3.66665887
5MP0005666_abnormal_adipose_tissue3.05415072
6MP0005085_abnormal_gallbladder_physiolo2.96825782
7MP0010329_abnormal_lipoprotein_level2.77595191
8MP0004130_abnormal_muscle_cell2.72013514
9MP0004185_abnormal_adipocyte_glucose2.68352245
10MP0003252_abnormal_bile_duct2.60011321
11MP0002971_abnormal_brown_adipose2.39004342
12MP0005451_abnormal_body_composition2.29172265
13MP0003724_increased_susceptibility_to2.22472761
14MP0000569_abnormal_digit_pigmentation2.05600988
15MP0003191_abnormal_cellular_cholesterol2.05234336
16MP0001661_extended_life_span2.04576597
17MP0005375_adipose_tissue_phenotype2.01284472
18MP0002118_abnormal_lipid_homeostasis1.92081511
19MP0008260_abnormal_autophagy1.91184956
20MP0003045_fibrosis1.87804847
21MP0004381_abnormal_hair_follicle1.83934649
22MP0005334_abnormal_fat_pad1.81999500
23MP0000609_abnormal_liver_physiology1.77054498
24MP0002138_abnormal_hepatobiliary_system1.70697609
25MP0002254_reproductive_system_inflammat1.70521498
26MP0008875_abnormal_xenobiotic_pharmacok1.70320373
27MP0006082_CNS_inflammation1.69249650
28MP0003300_gastrointestinal_ulcer1.64264504
29MP0002148_abnormal_hypersensitivity_rea1.60984151
30MP0000465_gastrointestinal_hemorrhage1.60176338
31MP0003868_abnormal_feces_composition1.59694402
32MP0009115_abnormal_fat_cell1.59580497
33MP0002132_abnormal_respiratory_system1.59349186
34MP0009764_decreased_sensitivity_to1.56121052
35MP0000383_abnormal_hair_follicle1.55384519
36MP0002398_abnormal_bone_marrow1.54239395
37MP0001790_abnormal_immune_system1.49648987
38MP0005387_immune_system_phenotype1.49648987
39MP0005058_abnormal_lysosome_morphology1.48755456
40MP0001851_eye_inflammation1.46237068
41MP0003172_abnormal_lysosome_physiology1.42660094
42MP0003656_abnormal_erythrocyte_physiolo1.42650066
43MP0004019_abnormal_vitamin_homeostasis1.41699284
44MP0010234_abnormal_vibrissa_follicle1.40268734
45MP0002405_respiratory_system_inflammati1.39689633
46MP0001666_abnormal_nutrient_absorption1.39386592
47MP0002166_altered_tumor_susceptibility1.38677975
48MP0000716_abnormal_immune_system1.37967585
49MP0003436_decreased_susceptibility_to1.36921791
50MP0000858_altered_metastatic_potential1.36565346
51MP0009333_abnormal_splenocyte_physiolog1.36516083
52MP0003183_abnormal_peptide_metabolism1.36515428
53MP0005397_hematopoietic_system_phenotyp1.35099926
54MP0001545_abnormal_hematopoietic_system1.35099926
55MP0003828_pulmonary_edema1.34379413
56MP0001800_abnormal_humoral_immune1.33593248
57MP0001835_abnormal_antigen_presentation1.30439595
58MP0002419_abnormal_innate_immunity1.27819416
59MP0005083_abnormal_biliary_tract1.27230553
60MP0002722_abnormal_immune_system1.26083116
61MP0000689_abnormal_spleen_morphology1.25510005
62MP0003866_abnormal_defecation1.21976840
63MP0005647_abnormal_sex_gland1.19234638
64MP0005535_abnormal_body_temperature1.18722711
65MP0004883_abnormal_blood_vessel1.18392084
66MP0003075_altered_response_to1.17929144
67MP0005166_decreased_susceptibility_to1.17290753
68MP0002006_tumorigenesis1.17087997
69MP0002009_preneoplasia1.16764558
70MP0002429_abnormal_blood_cell1.16324428
71MP0010352_gastrointestinal_tract_polyps1.16221054
72MP0000427_abnormal_hair_cycle1.15316562
73MP0010678_abnormal_skin_adnexa1.14628749
74MP0009763_increased_sensitivity_to1.13586074
75MP0008961_abnormal_basal_metabolism1.12305688
76MP0000579_abnormal_nail_morphology1.11140860
77MP0005332_abnormal_amino_acid1.10624477
78MP0002060_abnormal_skin_morphology1.10460057
79MP0000703_abnormal_thymus_morphology1.10197240
80MP0003950_abnormal_plasma_membrane1.09844162
81MP0009785_altered_susceptibility_to1.09763921
82MP0008004_abnormal_stomach_pH1.09357672
83MP0005025_abnormal_response_to1.08593607
84MP0002168_other_aberrant_phenotype1.08264068
85MP0002970_abnormal_white_adipose1.07945860
86MP0003303_peritoneal_inflammation1.07769001
87MP0005164_abnormal_response_to1.06807387
88MP0004510_myositis1.05016719
89MP0002876_abnormal_thyroid_physiology1.03522042
90MP0003690_abnormal_glial_cell1.02957808
91MP0004808_abnormal_hematopoietic_stem1.02552103
92MP0003806_abnormal_nucleotide_metabolis1.02450114
93MP0002723_abnormal_immune_serum1.00883875
94MP0002452_abnormal_antigen_presenting0.99869829
95MP0003705_abnormal_hypodermis_morpholog0.98985862
96MP0004264_abnormal_extraembryonic_tissu0.98976802
97MP0005409_darkened_coat_color0.97979490
98MP0004947_skin_inflammation0.97188757
99MP0006138_congestive_heart_failure0.96677335
100MP0010155_abnormal_intestine_physiology0.96152540
101MP0008469_abnormal_protein_level0.95879399
102MP0000003_abnormal_adipose_tissue0.94104282
103MP0005464_abnormal_platelet_physiology0.92950287
104MP0009643_abnormal_urine_homeostasis0.92893479
105MP0005448_abnormal_energy_balance0.92496192
106MP0002877_abnormal_melanocyte_morpholog0.91826778
107MP0003566_abnormal_cell_adhesion0.91181872
108MP0000685_abnormal_immune_system0.89692826
109MP0002078_abnormal_glucose_homeostasis0.89686613
110MP0003091_abnormal_cell_migration0.89104805
111MP0005000_abnormal_immune_tolerance0.89002562
112MP0000343_altered_response_to0.88959625
113MP0009278_abnormal_bone_marrow0.88566256
114MP0002396_abnormal_hematopoietic_system0.86733843
115MP0000249_abnormal_blood_vessel0.86451406
116MP0004484_altered_response_of0.86413997
117MP0005167_abnormal_blood-brain_barrier0.83540534
118MP0001873_stomach_inflammation0.82658400
119MP0001853_heart_inflammation0.82035047
120MP0003221_abnormal_cardiomyocyte_apopto0.81902536
121MP0009840_abnormal_foam_cell0.81745790
122MP0002837_dystrophic_cardiac_calcinosis0.81706114
123MP0003195_calcinosis0.81308015
124MP0001845_abnormal_inflammatory_respons0.81243586
125MP0005310_abnormal_salivary_gland0.80974919
126MP0001819_abnormal_immune_cell0.80719952
127MP0005319_abnormal_enzyme/_coenzyme0.80251173
128MP0002420_abnormal_adaptive_immunity0.80105612
129MP0001764_abnormal_homeostasis0.79740475
130MP0003453_abnormal_keratinocyte_physiol0.77257924
131MP0002998_abnormal_bone_remodeling0.77041524
132MP0003959_abnormal_lean_body0.76519917
133MP0002136_abnormal_kidney_physiology0.75623783
134MP0002928_abnormal_bile_duct0.73360362
135MP0005671_abnormal_response_to0.73207590
136MP0003646_muscle_fatigue0.72645340
137MP0002933_joint_inflammation0.71703019
138MP0001881_abnormal_mammary_gland0.71681561
139MP0005452_abnormal_adipose_tissue0.70927193
140MP0001879_abnormal_lymphatic_vessel0.70710703
141MP0002796_impaired_skin_barrier0.69452556
142MP0005584_abnormal_enzyme/coenzyme_acti0.68239687
143MP0001533_abnormal_skeleton_physiology0.67733588
144MP0003763_abnormal_thymus_physiology0.67420678
145MP0002277_abnormal_respiratory_mucosa0.67078743

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)3.99319149
2Deep venous thrombosis (HP:0002625)3.76367059
3Myositis (HP:0100614)3.71340176
4Renal cortical cysts (HP:0000803)3.59637499
5Myocardial infarction (HP:0001658)3.55129093
6Prolonged partial thromboplastin time (HP:0003645)3.46277373
7Orchitis (HP:0100796)3.46089134
8Joint hemorrhage (HP:0005261)3.43296363
9Hyperglycinuria (HP:0003108)3.31941983
10Hypoalphalipoproteinemia (HP:0003233)3.27997402
11Hypoglycemic coma (HP:0001325)3.23719084
12Complement deficiency (HP:0004431)3.23220738
13Retrobulbar optic neuritis (HP:0100654)3.23086731
14Optic neuritis (HP:0100653)3.23086731
15Hyperlipoproteinemia (HP:0010980)3.20690247
16Epidermoid cyst (HP:0200040)3.16064724
17Intrahepatic cholestasis (HP:0001406)3.13367690
18Xanthomatosis (HP:0000991)3.11579661
19Epistaxis (HP:0000421)3.04373488
20Gastrointestinal infarctions (HP:0005244)3.03586932
21Obstructive lung disease (HP:0006536)2.99987829
22Chronic obstructive pulmonary disease (HP:0006510)2.99987829
23Abnormality of the fingertips (HP:0001211)2.96040678
24Abnormality of proline metabolism (HP:0010907)2.90269390
25Hydroxyprolinuria (HP:0003080)2.90269390
26Meningitis (HP:0001287)2.86885385
27Polycythemia (HP:0001901)2.86883589
28Increased IgE level (HP:0003212)2.84706932
29Cellulitis (HP:0100658)2.82818781
30Hypertriglyceridemia (HP:0002155)2.78858115
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76599923
32Petechiae (HP:0000967)2.75405059
33Recurrent gram-negative bacterial infections (HP:0005420)2.75178783
34Pigmentary retinal degeneration (HP:0001146)2.74604712
35Vasculitis (HP:0002633)2.74551642
36Colitis (HP:0002583)2.71513337
37Purpura (HP:0000979)2.70345196
38Eczematoid dermatitis (HP:0000976)2.70225271
39Abnormality of glycine metabolism (HP:0010895)2.67426059
40Abnormality of serine family amino acid metabolism (HP:0010894)2.67426059
41Elevated erythrocyte sedimentation rate (HP:0003565)2.65678233
42Mediastinal lymphadenopathy (HP:0100721)2.64671411
43Osteomyelitis (HP:0002754)2.62417013
44Keratoconjunctivitis sicca (HP:0001097)2.61235070
45Gingival bleeding (HP:0000225)2.60347488
46Stomatitis (HP:0010280)2.59260202
47Ketosis (HP:0001946)2.56389728
48Prostate neoplasm (HP:0100787)2.55028749
49Autoimmune thrombocytopenia (HP:0001973)2.51448280
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51014480
51Insulin-resistant diabetes mellitus (HP:0000831)2.50971879
52Conjugated hyperbilirubinemia (HP:0002908)2.48828027
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46873622
54Urticaria (HP:0001025)2.45979140
55Gingivitis (HP:0000230)2.41424641
56Arterial thrombosis (HP:0004420)2.40745863
57Pulmonary embolism (HP:0002204)2.40642331
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39452995
59Abnormality of the renal cortex (HP:0011035)2.37098613
60Inflammation of the large intestine (HP:0002037)2.35844725
61Hypercholesterolemia (HP:0003124)2.35433456
62Recurrent fungal infections (HP:0002841)2.35078984
63Hemorrhage of the eye (HP:0011885)2.34913209
64Chronic mucocutaneous candidiasis (HP:0002728)2.34881992
65Recurrent cutaneous fungal infections (HP:0011370)2.34881992
66Encephalitis (HP:0002383)2.32003708
67Gastrointestinal stroma tumor (HP:0100723)2.31558116
68Upper limb muscle weakness (HP:0003484)2.31531373
69Interstitial pulmonary disease (HP:0006530)2.29704196
70Acanthosis nigricans (HP:0000956)2.26482323
71Increased mean platelet volume (HP:0011877)2.26135679
72Esophageal varix (HP:0002040)2.26082244
73Chromsome breakage (HP:0040012)2.25196875
74Keratoconjunctivitis (HP:0001096)2.23587092
75Chest pain (HP:0100749)2.23361450
76Fatigue (HP:0012378)2.23074209
77Congenital stationary night blindness (HP:0007642)2.21079909
78Hyperammonemia (HP:0001987)2.19427293
79Amyloidosis (HP:0011034)2.18877841
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.17631171
81Recurrent viral infections (HP:0004429)2.15282192
82Hypolipoproteinemia (HP:0010981)2.14543870
83Pulmonary infiltrates (HP:0002113)2.13395606
84Hyperkalemia (HP:0002153)2.13375944
85Pustule (HP:0200039)2.11476938
86Distal lower limb muscle weakness (HP:0009053)2.08561922
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07681193
88Agammaglobulinemia (HP:0004432)2.07411488
89Autoimmune hemolytic anemia (HP:0001890)2.07349735
90Episodic fever (HP:0001954)2.05549677
91Abnormality of fatty-acid metabolism (HP:0004359)2.04598960
92Abnormality of complement system (HP:0005339)2.04307835
93T lymphocytopenia (HP:0005403)2.03855395
94Abnormal platelet function (HP:0011869)2.03731600
95Impaired platelet aggregation (HP:0003540)2.03731600
96Malnutrition (HP:0004395)2.03521409
97Gastrointestinal inflammation (HP:0004386)2.03512284
98Tetraparesis (HP:0002273)2.03408235
99Increased serum ferritin (HP:0003281)2.02868454
100Pancreatitis (HP:0001733)2.02804149
101Aplasia cutis congenita (HP:0001057)2.02651306
102Duplicated collecting system (HP:0000081)1.99804610
103Distal lower limb amyotrophy (HP:0008944)1.99512722
104Slow saccadic eye movements (HP:0000514)1.99155624
105Anorexia (HP:0002039)1.98314998
106Abnormality of the common coagulation pathway (HP:0010990)1.98259089
107Ketoacidosis (HP:0001993)1.98229889
108Hemoptysis (HP:0002105)1.98029550
109Difficulty running (HP:0009046)1.97776766
110Anal stenosis (HP:0002025)1.97719139
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97133682
112Joint swelling (HP:0001386)1.96119573
113Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95790405
114Dicarboxylic aciduria (HP:0003215)1.95790405
115Thick nail (HP:0001805)1.95486397
116Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93978921
117Muscle fiber splitting (HP:0003555)1.93269546
118Abnormality of T cell number (HP:0011839)1.92301874
119Abnormality of T cells (HP:0002843)1.91796137
120Prolonged bleeding time (HP:0003010)1.91750327
121Periodontitis (HP:0000704)1.91659541
122Oligomenorrhea (HP:0000876)1.91256390
123Microcytic anemia (HP:0001935)1.90851823
124Hypoglycemic seizures (HP:0002173)1.90698809
125Hyperinsulinemic hypoglycemia (HP:0000825)1.90505354
126Recurrent bacterial skin infections (HP:0005406)1.90076101
127Hyporeflexia of lower limbs (HP:0002600)1.89967037
128Asymmetric septal hypertrophy (HP:0001670)1.88967523
129Recurrent skin infections (HP:0001581)1.88118583
130Recurrent abscess formation (HP:0002722)1.87267369
131Hyperglycemia (HP:0003074)1.86924698
132Thrombophlebitis (HP:0004418)1.86810471
133Chronic diarrhea (HP:0002028)1.86801473
134Abnormality of iron homeostasis (HP:0011031)1.86746958
135Systemic lupus erythematosus (HP:0002725)1.85642108
136Acute hepatic failure (HP:0006554)1.85480730
137Seborrheic dermatitis (HP:0001051)1.85252257
138Gangrene (HP:0100758)1.84760454
139Nephritis (HP:0000123)1.83511207
140Enlarged kidneys (HP:0000105)1.83406572
141Menorrhagia (HP:0000132)1.82059636
142Abnormality of sulfur amino acid metabolism (HP:0004339)1.82016212
143Granulocytopenia (HP:0001913)1.81793528
144Panhypogammaglobulinemia (HP:0003139)1.81441415
145Hepatosplenomegaly (HP:0001433)1.81012202
146Spontaneous hematomas (HP:0007420)1.80245144
147Osteolytic defects of the hand bones (HP:0009699)1.80031492
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.80031492
149Acanthocytosis (HP:0001927)1.79929008
150Acne (HP:0001061)1.79037676
151Ventricular fibrillation (HP:0001663)1.77553930
152Abnormality of purine metabolism (HP:0004352)1.77028311
153Abnormal platelet volume (HP:0011876)1.76904465
154Increased CSF protein (HP:0002922)1.76205063
155Exercise-induced myalgia (HP:0003738)1.76174167
156Fair hair (HP:0002286)1.75889797
157Abnormality of nucleobase metabolism (HP:0010932)1.75654238
158Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75338170
159Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75097172
160Skin ulcer (HP:0200042)1.74954782
161Abnormality of skeletal muscle fiber size (HP:0012084)1.74715717
162Recurrent sinusitis (HP:0011108)1.74235023
163Abnormality of pyrimidine metabolism (HP:0004353)1.72906092
164Tubulointerstitial nephritis (HP:0001970)1.71499851
165Hyperglycinemia (HP:0002154)1.71179787
166Neoplasm of the tracheobronchial system (HP:0100552)1.69928412
167Skin nodule (HP:0200036)1.69477117
168Lip pit (HP:0100267)1.68958788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.01361135
2CAMK1G3.30669098
3INSRR3.23620069
4PRPF4B3.20250550
5SIK13.11304456
6TAOK32.62206245
7MAP2K32.56875627
8IRAK32.23257254
9MAP3K132.09831339
10MAP3K142.09740772
11JAK11.96470229
12FGFR41.93571840
13PRKAA21.90315717
14LATS11.88514873
15MAP3K21.81815780
16TXK1.78936670
17KSR21.78680040
18BLK1.75868060
19MAP3K11.71788324
20MAP3K31.63281988
21MAP4K11.59750140
22CDK121.58376863
23GRK11.53384055
24YES11.50988206
25TYK21.50122021
26NUAK11.44363017
27JAK31.43436367
28FGFR31.42611800
29ERN11.38796460
30IKBKE1.37207157
31BRD41.30416867
32MAP3K71.28964745
33DMPK1.25865577
34EPHB11.23973634
35CDK91.23773618
36RIPK11.22368711
37IRAK41.21319130
38MST1R1.18318938
39SIK21.17587622
40TGFBR21.16829103
41FRK1.14782101
42PIK3CG1.14154771
43EPHA31.09186045
44SIK31.08524845
45FGFR21.08168815
46RIPK41.08018602
47BCKDK1.06944574
48CSK1.06591812
49TEC1.02015373
50TAOK10.99931422
51FGR0.98188281
52STK30.97798813
53HCK0.95579079
54ITK0.91821314
55MAP3K60.91133026
56PRKAA10.88495704
57MAP3K120.87193142
58PIK3CA0.86924991
59NLK0.86704548
60TNIK0.85958763
61MARK20.85747965
62TIE10.85156757
63PRKCQ0.84687238
64RAF10.83887824
65ACVR1B0.83556694
66LRRK20.83114004
67SGK30.80791142
68JAK20.80371596
69PKN10.79865925
70RET0.78033480
71IRAK10.75774297
72SMG10.74112323
73ZAK0.73861027
74MAPK70.73385764
75PTK60.71384219
76TRIB30.71287757
77STK40.70949126
78TBK10.70928909
79STK100.70375870
80FES0.70277245
81IKBKB0.70274921
82PRKD20.69958717
83MATK0.69631982
84LCK0.68730082
85CDK60.67562052
86CHUK0.67334768
87SGK20.66831918
88MAPK110.66461850
89MAP3K110.65060415
90SCYL20.62827971
91PDGFRB0.61575295
92MST40.60156673
93CDK40.59481639
94OBSCN0.59378738
95STK110.58534174
96PRKG20.58015764
97SGK10.57767533
98STK240.57357761
99TAOK20.56097929
100TRPM70.55621263
101ZAP700.55425400
102KIT0.54371320
103LMTK20.53933555
104EEF2K0.53912191
105HIPK20.53828026
106TTN0.53691222
107BTK0.52806652
108PRKCH0.52617635
109MYLK0.52576249
110MAPK120.51560983
111CAMK10.51528640
112MARK30.50865701
113MAP2K60.50530515
114BMPR20.50476890
115MAP3K100.50004149
116IGF1R0.49508277
117MTOR0.49492844
118TNK20.49340749
119STK38L0.48430297
120WNK10.48077598
121PDPK10.48040500
122BMX0.47649205
123IRAK20.46885650
124KSR10.46242162
125CSF1R0.45811712
126ABL10.45725834
127LYN0.45337359
128PDK10.43143840
129SYK0.43030514
130PKN20.42561917
131PIM10.42476638
132GRK60.41794846
133PDK20.41537144
134NEK90.41062259

Predicted pathways (KEGG)

RankGene SetZ-score
1PPAR signaling pathway_Homo sapiens_hsa033202.67053319
2Fatty acid degradation_Homo sapiens_hsa000712.55623670
3Propanoate metabolism_Homo sapiens_hsa006402.45747455
4Staphylococcus aureus infection_Homo sapiens_hsa051502.43843049
5Fatty acid biosynthesis_Homo sapiens_hsa000612.42272352
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.39855064
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32366504
8Fatty acid metabolism_Homo sapiens_hsa012122.28390849
9Nitrogen metabolism_Homo sapiens_hsa009102.22263691
10Lysine degradation_Homo sapiens_hsa003102.10667661
11ABC transporters_Homo sapiens_hsa020102.09049552
12Caffeine metabolism_Homo sapiens_hsa002322.08706291
13Tryptophan metabolism_Homo sapiens_hsa003802.07992393
14Complement and coagulation cascades_Homo sapiens_hsa046102.07865259
15beta-Alanine metabolism_Homo sapiens_hsa004101.84675794
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.79949128
17Glycerolipid metabolism_Homo sapiens_hsa005611.74106159
18Arginine biosynthesis_Homo sapiens_hsa002201.69956707
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68645344
20Allograft rejection_Homo sapiens_hsa053301.65152691
21Tuberculosis_Homo sapiens_hsa051521.63490366
22Other glycan degradation_Homo sapiens_hsa005111.58015111
23Peroxisome_Homo sapiens_hsa041461.55533337
24Non-small cell lung cancer_Homo sapiens_hsa052231.49320100
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49149266
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46511532
27Chronic myeloid leukemia_Homo sapiens_hsa052201.46304641
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38769961
29Pancreatic cancer_Homo sapiens_hsa052121.34907263
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.31402119
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.28182006
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.24099188
33Butanoate metabolism_Homo sapiens_hsa006501.23261708
34Retinol metabolism_Homo sapiens_hsa008301.20622052
35Renal cell carcinoma_Homo sapiens_hsa052111.19071895
36Histidine metabolism_Homo sapiens_hsa003401.18615710
37Primary immunodeficiency_Homo sapiens_hsa053401.18006019
38Fatty acid elongation_Homo sapiens_hsa000621.15615146
39Viral myocarditis_Homo sapiens_hsa054161.14485507
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13722489
41Insulin resistance_Homo sapiens_hsa049311.13676241
42Vitamin digestion and absorption_Homo sapiens_hsa049771.13442673
43Type I diabetes mellitus_Homo sapiens_hsa049401.12348011
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09755356
45Antigen processing and presentation_Homo sapiens_hsa046121.09698386
46Legionellosis_Homo sapiens_hsa051341.09373444
47Fat digestion and absorption_Homo sapiens_hsa049751.08639574
48Bile secretion_Homo sapiens_hsa049761.04304616
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00801025
50Hepatitis B_Homo sapiens_hsa051610.99321788
51Herpes simplex infection_Homo sapiens_hsa051680.98516453
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98357470
53Osteoclast differentiation_Homo sapiens_hsa043800.96237092
54Prolactin signaling pathway_Homo sapiens_hsa049170.95343186
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95153753
56Starch and sucrose metabolism_Homo sapiens_hsa005000.94999737
57Asthma_Homo sapiens_hsa053100.93083891
58VEGF signaling pathway_Homo sapiens_hsa043700.92425112
59Type II diabetes mellitus_Homo sapiens_hsa049300.92048932
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91730764
61Phenylalanine metabolism_Homo sapiens_hsa003600.89787393
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87648567
63Pertussis_Homo sapiens_hsa051330.84830842
64Hematopoietic cell lineage_Homo sapiens_hsa046400.83458883
65Phagosome_Homo sapiens_hsa041450.83398136
66Thyroid cancer_Homo sapiens_hsa052160.83382796
67Endometrial cancer_Homo sapiens_hsa052130.82325982
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80679911
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.79245253
70African trypanosomiasis_Homo sapiens_hsa051430.78462048
71* AMPK signaling pathway_Homo sapiens_hsa041520.75630660
72Tyrosine metabolism_Homo sapiens_hsa003500.74722813
73Measles_Homo sapiens_hsa051620.74720472
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.73168123
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72637787
76B cell receptor signaling pathway_Homo sapiens_hsa046620.71318395
77mTOR signaling pathway_Homo sapiens_hsa041500.69878525
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69857251
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.69661981
80Amoebiasis_Homo sapiens_hsa051460.69370270
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68925096
82Ovarian steroidogenesis_Homo sapiens_hsa049130.68343025
83Choline metabolism in cancer_Homo sapiens_hsa052310.67728995
84Shigellosis_Homo sapiens_hsa051310.67328976
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67080600
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.65664972
87Chemical carcinogenesis_Homo sapiens_hsa052040.65093337
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64969539
89GnRH signaling pathway_Homo sapiens_hsa049120.63227538
90Malaria_Homo sapiens_hsa051440.60271396
91* Sphingolipid signaling pathway_Homo sapiens_hsa040710.59760588
92Apoptosis_Homo sapiens_hsa042100.59594501
93Pentose phosphate pathway_Homo sapiens_hsa000300.58921724
94Viral carcinogenesis_Homo sapiens_hsa052030.58888836
95Lysosome_Homo sapiens_hsa041420.58700753
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58637766
97Dorso-ventral axis formation_Homo sapiens_hsa043200.57772866
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57302415
99Endocytosis_Homo sapiens_hsa041440.57222607
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.56004996
101Glucagon signaling pathway_Homo sapiens_hsa049220.55609971
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55117462
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54890706
104Pyruvate metabolism_Homo sapiens_hsa006200.54877395
105Leishmaniasis_Homo sapiens_hsa051400.54519185
106HIF-1 signaling pathway_Homo sapiens_hsa040660.53808888
107ErbB signaling pathway_Homo sapiens_hsa040120.53279460
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52714714
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52211799
110Inositol phosphate metabolism_Homo sapiens_hsa005620.50528295
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50315590
112Salmonella infection_Homo sapiens_hsa051320.50264698
113Rheumatoid arthritis_Homo sapiens_hsa053230.50015411
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48923881
115Long-term potentiation_Homo sapiens_hsa047200.48692951
116Prostate cancer_Homo sapiens_hsa052150.48679071
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.48582233
118Autoimmune thyroid disease_Homo sapiens_hsa053200.48325230
119Glioma_Homo sapiens_hsa052140.47930025
120TNF signaling pathway_Homo sapiens_hsa046680.47837994
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47819041
122Hepatitis C_Homo sapiens_hsa051600.47176817
123Toxoplasmosis_Homo sapiens_hsa051450.45849039
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45519523
125ECM-receptor interaction_Homo sapiens_hsa045120.45157352
126Chemokine signaling pathway_Homo sapiens_hsa040620.44790673
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44155979
128T cell receptor signaling pathway_Homo sapiens_hsa046600.43431797
129Influenza A_Homo sapiens_hsa051640.43259983
130Renin-angiotensin system_Homo sapiens_hsa046140.43235797
131Acute myeloid leukemia_Homo sapiens_hsa052210.43215139
132Insulin signaling pathway_Homo sapiens_hsa049100.42453750
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42320797
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42291807
135Small cell lung cancer_Homo sapiens_hsa052220.39446348
136Circadian rhythm_Homo sapiens_hsa047100.37473892
137Graft-versus-host disease_Homo sapiens_hsa053320.36445576
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36161426
139Selenocompound metabolism_Homo sapiens_hsa004500.35399484
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.35168644
141Steroid biosynthesis_Homo sapiens_hsa001000.35086967
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34227762
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34146845
144Renin secretion_Homo sapiens_hsa049240.32262633
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.31891329
146Protein digestion and absorption_Homo sapiens_hsa049740.31664711
147cAMP signaling pathway_Homo sapiens_hsa040240.31558556
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30944721
149FoxO signaling pathway_Homo sapiens_hsa040680.30553676
150Platelet activation_Homo sapiens_hsa046110.27825777
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.27382587

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