PPP2R2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.35724474
2nuclear pore complex assembly (GO:0051292)4.79631007
3nuclear pore organization (GO:0006999)4.72714000
4DNA replication-dependent nucleosome organization (GO:0034723)4.51539477
5DNA replication-dependent nucleosome assembly (GO:0006335)4.51539477
6DNA replication checkpoint (GO:0000076)4.50369603
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.46264341
8mitotic metaphase plate congression (GO:0007080)4.36021182
9protein localization to kinetochore (GO:0034501)4.11265877
10DNA replication initiation (GO:0006270)4.08525406
11regulation of gene silencing by RNA (GO:0060966)4.07543380
12regulation of posttranscriptional gene silencing (GO:0060147)4.07543380
13regulation of gene silencing by miRNA (GO:0060964)4.07543380
14regulation of nuclear cell cycle DNA replication (GO:0033262)3.81557351
15histone arginine methylation (GO:0034969)3.79617926
16metaphase plate congression (GO:0051310)3.79615013
17regulation of centriole replication (GO:0046599)3.72880414
18chromatin remodeling at centromere (GO:0031055)3.72633484
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.67798498
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.67798498
21establishment of chromosome localization (GO:0051303)3.66356978
22protein localization to chromosome, centromeric region (GO:0071459)3.61922000
23pore complex assembly (GO:0046931)3.51718852
24peptidyl-arginine omega-N-methylation (GO:0035247)3.50968786
25mitotic nuclear envelope disassembly (GO:0007077)3.49317538
26regulation of autophagic vacuole assembly (GO:2000785)3.48858826
27cullin deneddylation (GO:0010388)3.48694379
28histone exchange (GO:0043486)3.47607321
29kinetochore organization (GO:0051383)3.47512176
30CENP-A containing nucleosome assembly (GO:0034080)3.46597440
31DNA strand elongation involved in DNA replication (GO:0006271)3.46318950
32regulation of helicase activity (GO:0051095)3.43717934
33DNA replication-independent nucleosome assembly (GO:0006336)3.41104138
34DNA replication-independent nucleosome organization (GO:0034724)3.41104138
35purine nucleobase biosynthetic process (GO:0009113)3.40340296
36nucleobase biosynthetic process (GO:0046112)3.39205253
37protein deneddylation (GO:0000338)3.38672256
38DNA double-strand break processing (GO:0000729)3.38398309
39ribosome biogenesis (GO:0042254)3.37971148
40DNA strand elongation (GO:0022616)3.37708888
41ribosome assembly (GO:0042255)3.35677184
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.32553936
43regulation of centrosome cycle (GO:0046605)3.32397856
44membrane disassembly (GO:0030397)3.32019216
45nuclear envelope disassembly (GO:0051081)3.32019216
46kinetochore assembly (GO:0051382)3.31944845
47piRNA metabolic process (GO:0034587)3.28702668
48protein K6-linked ubiquitination (GO:0085020)3.28293991
49regulation of double-strand break repair via homologous recombination (GO:0010569)3.25449253
50spliceosomal snRNP assembly (GO:0000387)3.23958985
51single strand break repair (GO:0000012)3.23240007
52telomere maintenance via semi-conservative replication (GO:0032201)3.21380638
53regulation of meiosis I (GO:0060631)3.20328111
54folic acid-containing compound biosynthetic process (GO:0009396)3.19938757
55synaptonemal complex assembly (GO:0007130)3.18978742
56peptidyl-arginine methylation (GO:0018216)3.18596409
57peptidyl-arginine N-methylation (GO:0035246)3.18596409
58spindle checkpoint (GO:0031577)3.18278488
59formation of translation preinitiation complex (GO:0001731)3.17712575
60regulation of telomere maintenance via telomerase (GO:0032210)3.16206596
61microtubule depolymerization (GO:0007019)3.13892558
62meiotic chromosome segregation (GO:0045132)3.07619906
63telomere maintenance via recombination (GO:0000722)3.07248677
64establishment of integrated proviral latency (GO:0075713)3.07192214
65potassium ion export (GO:0071435)3.07068089
66protein complex localization (GO:0031503)3.05686059
67regulation of vacuole organization (GO:0044088)3.05072299
68regulation of T cell cytokine production (GO:0002724)3.04382928
69cellular response to interleukin-15 (GO:0071350)3.03458445
70mitotic recombination (GO:0006312)3.01999188
71mitotic spindle checkpoint (GO:0071174)3.00585950
72synaptonemal complex organization (GO:0070193)3.00406474
73maturation of SSU-rRNA (GO:0030490)3.00076630
74mitotic sister chromatid segregation (GO:0000070)2.99342929
75replication fork processing (GO:0031297)2.98106725
76response to interleukin-15 (GO:0070672)2.97055473
77mitotic chromosome condensation (GO:0007076)2.96147416
78regulation of chromosome segregation (GO:0051983)2.96128343
79negative regulation of chromosome segregation (GO:0051985)2.95699293
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.94870069
81negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94870069
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94870069
83negative regulation of sister chromatid segregation (GO:0033046)2.94870069
84binding of sperm to zona pellucida (GO:0007339)2.94862014
85spliceosomal complex assembly (GO:0000245)2.94101230
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.93385417
87positive regulation of chromosome segregation (GO:0051984)2.93285468
88transcription-coupled nucleotide-excision repair (GO:0006283)2.91948086
89regulation of interleukin-6 biosynthetic process (GO:0045408)2.91704791
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91688174
91DNA unwinding involved in DNA replication (GO:0006268)2.91537792
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.90753836
93regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90460063
94pre-miRNA processing (GO:0031054)2.90099074
95mismatch repair (GO:0006298)2.89987159
96regulation of histone H3-K9 methylation (GO:0051570)2.89082917
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88635661
98regulation of mitotic spindle checkpoint (GO:1903504)2.88635661
99protein localization to chromosome (GO:0034502)2.88525591
100positive regulation of mitotic sister chromatid separation (GO:1901970)2.88076478
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88076478
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88076478
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87142196
104telomere maintenance via telomere lengthening (GO:0010833)2.86438483
105rRNA modification (GO:0000154)2.85991059
106sperm-egg recognition (GO:0035036)2.85638603
107regulation of T cell tolerance induction (GO:0002664)2.85551029
108mitotic sister chromatid cohesion (GO:0007064)2.84617588
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84588752
110attachment of spindle microtubules to kinetochore (GO:0008608)2.84436222
111spindle assembly checkpoint (GO:0071173)2.84294522
112membrane tubulation (GO:0097320)2.80959086
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80215516
114negative regulation of T cell mediated immunity (GO:0002710)2.79682883
115positive regulation of gamma-delta T cell activation (GO:0046645)2.75412333
116cellular response to ethanol (GO:0071361)2.66775364
117positive regulation of mast cell activation (GO:0033005)2.64691038
118interleukin-1-mediated signaling pathway (GO:0070498)2.64639780
119cellular response to zinc ion (GO:0071294)2.60773279
120L-fucose catabolic process (GO:0042355)2.60338349
121fucose catabolic process (GO:0019317)2.60338349
122L-fucose metabolic process (GO:0042354)2.60338349
123mannose metabolic process (GO:0006013)2.60191161
124activated T cell proliferation (GO:0050798)2.59997365
125histone H3-K36 demethylation (GO:0070544)2.59384171
126negative regulation of organelle assembly (GO:1902116)2.57860404
127negative regulation of macroautophagy (GO:0016242)2.57348915
128macroautophagy (GO:0016236)2.57148504
129positive regulation of granulocyte differentiation (GO:0030854)2.56949892
130negative regulation of cAMP-mediated signaling (GO:0043951)2.56475787
131negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56464098
132negative regulation of cell killing (GO:0031342)2.56464098
133regulation of gamma-delta T cell differentiation (GO:0045586)2.55811701
134regulation of gamma-delta T cell activation (GO:0046643)2.54577874
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53091903
136regulation of ARF GTPase activity (GO:0032312)2.52969002
137TOR signaling (GO:0031929)2.51679181
138cellular extravasation (GO:0045123)2.50543564
139CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.50097477
140cerebellar Purkinje cell differentiation (GO:0021702)2.48767552
141positive regulation of CREB transcription factor activity (GO:0032793)2.48355859
142alpha-beta T cell differentiation (GO:0046632)2.47877292
143membrane depolarization during action potential (GO:0086010)2.44706422
144negative regulation of interleukin-12 production (GO:0032695)2.42735598
145regulation of mast cell activation involved in immune response (GO:0033006)2.42251709
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.41900027
147positive regulation of mast cell degranulation (GO:0043306)2.41900027
148regulation of establishment of cell polarity (GO:2000114)2.41575473
149adaptation of signaling pathway (GO:0023058)2.41072567
150regulation of B cell receptor signaling pathway (GO:0050855)2.39605659
151regulation of tolerance induction (GO:0002643)2.35879285
152protein K63-linked deubiquitination (GO:0070536)2.33665675
153T-helper cell differentiation (GO:0042093)2.33508201
154CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.33508201
155regulation of cytokine production involved in inflammatory response (GO:1900015)2.32682106
156signal complex assembly (GO:0007172)2.32335291
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32225058
158regulation of mast cell activation (GO:0033003)2.30424430
159positive regulation of fatty acid transport (GO:2000193)2.28225699
160positive regulation of prostaglandin secretion (GO:0032308)2.27792738
161cAMP catabolic process (GO:0006198)2.27028075
162potassium ion import (GO:0010107)2.26293492
163mast cell degranulation (GO:0043303)2.26184973
164mast cell activation involved in immune response (GO:0002279)2.26184973
165positive regulation of natural killer cell differentiation (GO:0032825)2.26061499
166mast cell activation (GO:0045576)2.25635434
167locomotory exploration behavior (GO:0035641)2.25494031
168primary amino compound metabolic process (GO:1901160)2.25299367
169regulation of dopamine secretion (GO:0014059)2.22182598
170positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.21874499
171regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21617065
172adrenergic receptor signaling pathway (GO:0071875)2.21322221
173CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.20825710
174regulation of fatty acid oxidation (GO:0046320)2.19993944
175alpha-beta T cell activation (GO:0046631)2.19974961
176regulation of mast cell degranulation (GO:0043304)2.19963677
177cellular response to ATP (GO:0071318)2.19375060
178indolalkylamine catabolic process (GO:0046218)2.15449980
179tryptophan catabolic process (GO:0006569)2.15449980
180indole-containing compound catabolic process (GO:0042436)2.15449980
181negative regulation of reactive oxygen species metabolic process (GO:2000378)2.14313384
182activation of protein kinase B activity (GO:0032148)2.14042452
183synaptic transmission, cholinergic (GO:0007271)2.13930453
184regulation of T cell mediated immunity (GO:0002709)2.13799121
185regulation of synaptic transmission, dopaminergic (GO:0032225)2.13755919
186regulation of granulocyte differentiation (GO:0030852)2.12470604
187protein targeting to lysosome (GO:0006622)2.12255173
188establishment of protein localization to vacuole (GO:0072666)2.12255173
189protein targeting to vacuole (GO:0006623)2.12255173
190regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.12009143
191granulocyte differentiation (GO:0030851)2.11721372
192regulation of synaptic vesicle transport (GO:1902803)2.09814948
193NAD biosynthetic process (GO:0009435)2.09348856
194positive regulation of defense response to virus by host (GO:0002230)2.08625708
195CD4-positive, alpha-beta T cell activation (GO:0035710)2.08318148
196positive regulation of neurotransmitter secretion (GO:0001956)2.07634589
197regulation of short-term neuronal synaptic plasticity (GO:0048172)2.07332151
198gamma-aminobutyric acid transport (GO:0015812)2.06806250
199T cell differentiation involved in immune response (GO:0002292)2.06243607
200alpha-beta T cell activation involved in immune response (GO:0002287)2.06243607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.05626226
2E2F7_22180533_ChIP-Seq_HELA_Human7.85580079
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92301425
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.83783357
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.76421888
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58815268
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.56749419
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56729908
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11173899
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10453764
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96388422
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88264723
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87043208
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81957729
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.79219381
16EZH2_22144423_ChIP-Seq_EOC_Human2.65141104
17GBX2_23144817_ChIP-Seq_PC3_Human2.59143910
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55586427
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.54985278
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48937124
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.48718308
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47870831
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.46183925
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45814998
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.41384960
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38710694
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38710694
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38710694
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.36316142
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31351735
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24750279
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24355301
33SALL1_21062744_ChIP-ChIP_HESCs_Human2.23467616
34NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18348039
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08957375
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08184914
37MYCN_18555785_ChIP-Seq_MESCs_Mouse2.05010604
38* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02116148
39RUNX_20019798_ChIP-Seq_JUKART_Human2.01737197
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.97058907
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94787936
42VDR_23849224_ChIP-Seq_CD4+_Human1.93517578
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89000000
44XRN2_22483619_ChIP-Seq_HELA_Human1.88844025
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.85636861
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82817595
47ER_23166858_ChIP-Seq_MCF-7_Human1.81418122
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79434344
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79355849
50TTF2_22483619_ChIP-Seq_HELA_Human1.75670995
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73877322
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.73321371
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.71087109
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69076692
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.67802502
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66948121
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63713057
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63457195
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60482491
60SCL_19346495_ChIP-Seq_HPC-7_Human1.59463275
61DROSHA_22980978_ChIP-Seq_HELA_Human1.58739311
62DCP1A_22483619_ChIP-Seq_HELA_Human1.57776004
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57471667
64FOXP3_21729870_ChIP-Seq_TREG_Human1.57299297
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55931468
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54559132
67GATA1_22025678_ChIP-Seq_K562_Human1.54543305
68GABP_19822575_ChIP-Seq_HepG2_Human1.53712905
69REST_21632747_ChIP-Seq_MESCs_Mouse1.48521134
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.48000367
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47791445
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46261005
73KDM2B_26808549_Chip-Seq_DND41_Human1.45669113
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45641478
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45026660
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43521770
77ELK1_19687146_ChIP-ChIP_HELA_Human1.43357904
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39606063
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38101312
80GATA1_19941826_ChIP-Seq_K562_Human1.37157371
81AR_21572438_ChIP-Seq_LNCaP_Human1.35047683
82* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34518742
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33987204
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32796287
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32410844
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32129700
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31209954
88* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31206408
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27546511
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26997469
91AR_21909140_ChIP-Seq_LNCAP_Human1.26493551
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26406967
93SPI1_23127762_ChIP-Seq_K562_Human1.26158822
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26134390
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25794674
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25202920
97* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24613579
98KDM5A_27292631_Chip-Seq_BREAST_Human1.23163920
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18926765
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18675826
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18618315
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16204077
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16204077
104RXR_22108803_ChIP-Seq_LS180_Human1.16046131
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16032646
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15718541
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15411418
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.15336275
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14483693
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14232681
111MAF_26560356_Chip-Seq_TH2_Human1.13729260
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13296186
113IGF1R_20145208_ChIP-Seq_DFB_Human1.13244983
114ZNF274_21170338_ChIP-Seq_K562_Hela1.13217244
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12382465
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12314468
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.10043898
118* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09762531
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09333801
120KDM2B_26808549_Chip-Seq_K562_Human1.08965749
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08715323
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08431252
123MYB_26560356_Chip-Seq_TH2_Human1.07717696
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07302086
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06921661
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06915773
127KDM2B_26808549_Chip-Seq_JURKAT_Human1.06787032
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06302814
129OCT4_19829295_ChIP-Seq_ESCs_Human1.06256815
130NANOG_21062744_ChIP-ChIP_HESCs_Human1.05329053
131GATA1_19941827_ChIP-Seq_MEL_Mouse1.04928592
132* WDR5_24793694_ChIP-Seq_LNCAP_Human1.04825161
133REST_18959480_ChIP-ChIP_MESCs_Mouse1.04652804
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03970869
135* RARB_27405468_Chip-Seq_BRAIN_Mouse1.03735962
136VDR_24787735_ChIP-Seq_THP-1_Human1.02885204
137GATA3_26560356_Chip-Seq_TH2_Human1.02785164
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01633945
139VDR_22108803_ChIP-Seq_LS180_Human1.01041563
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00505876
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99553721
142MYB_26560356_Chip-Seq_TH1_Human0.98585392
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.97562951
144GATA2_19941826_ChIP-Seq_K562_Human0.97297761
145IRF8_27001747_Chip-Seq_BMDM_Mouse0.96919042
146MYC_18940864_ChIP-ChIP_HL60_Human0.96650414
147SRF_21415370_ChIP-Seq_HL-1_Mouse0.96348241
148VDR_21846776_ChIP-Seq_THP-1_Human0.96255869
149MAF_26560356_Chip-Seq_TH1_Human0.95483115
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95401122
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.95177284
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94951944
153SMAD4_21741376_ChIP-Seq_ESCs_Human0.94572471
154UTX_26944678_Chip-Seq_JUKART_Human0.94559156
155GATA3_27048872_Chip-Seq_THYMUS_Human0.93861189
156* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93472441
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92146311
158ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92118529
159RNF2_27304074_Chip-Seq_ESCs_Mouse0.92039636
160* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91728799
161* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.91596261
162SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91562014
163NOTCH1_21737748_ChIP-Seq_TLL_Human0.91559289
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.91137601
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90922492
166JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89407384
167OCT1_27270436_Chip-Seq_PROSTATE_Human0.88437381
168PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88271249
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88114992
170* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87907250
171HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87879883
172* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87725452
173STAT3_23295773_ChIP-Seq_U87_Human0.85785720
174TCF7_22412390_ChIP-Seq_EML_Mouse0.85234951
175CIITA_25753668_ChIP-Seq_RAJI_Human0.85053318
176ERA_21632823_ChIP-Seq_H3396_Human0.84760439
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.84034804
178TCF4_23295773_ChIP-Seq_U87_Human0.83874578
179MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83766511
180KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83630590
181GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83155374
182PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82385852
183OCT4_20526341_ChIP-Seq_ESCs_Human0.82325232
184SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82306087
185NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82271938
186STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82185488
187HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81818347
188SOX2_16153702_ChIP-ChIP_HESCs_Human0.81700422
189PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80742712
190ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80735086
191BCAT_22108803_ChIP-Seq_LS180_Human0.80335603
192KLF4_19829295_ChIP-Seq_ESCs_Human0.80124889
193ESR2_21235772_ChIP-Seq_MCF-7_Human0.80080673
194TP53_16413492_ChIP-PET_HCT116_Human0.79826126
195STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78574306
196EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78548575
197VDR_24763502_ChIP-Seq_THP-1_Human0.77412846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.32330115
2MP0003111_abnormal_nucleus_morphology4.19203291
3MP0003693_abnormal_embryo_hatching4.06369271
4MP0010094_abnormal_chromosome_stability4.00016721
5MP0004957_abnormal_blastocyst_morpholog3.55251134
6MP0008058_abnormal_DNA_repair3.50814547
7MP0003077_abnormal_cell_cycle3.25425565
8MP0003123_paternal_imprinting2.94512013
9MP0008877_abnormal_DNA_methylation2.91441861
10MP0009840_abnormal_foam_cell2.55024799
11MP0008007_abnormal_cellular_replicative2.54311478
12MP0005410_abnormal_fertilization2.52037429
13MP0008932_abnormal_embryonic_tissue2.42933014
14MP0004130_abnormal_muscle_cell2.38384826
15MP0000569_abnormal_digit_pigmentation2.36916313
16MP0003890_abnormal_embryonic-extraembry2.34510784
17MP0005646_abnormal_pituitary_gland2.34152079
18MP0006292_abnormal_olfactory_placode2.32164821
19MP0004133_heterotaxia2.29832997
20MP0002653_abnormal_ependyma_morphology2.27172643
21MP0001929_abnormal_gametogenesis2.11833959
22MP0003646_muscle_fatigue2.07285190
23MP0002210_abnormal_sex_determination2.06795606
24MP0001968_abnormal_touch/_nociception2.03873919
25MP0004510_myositis2.03793362
26MP0003436_decreased_susceptibility_to2.01453860
27MP0003763_abnormal_thymus_physiology1.99060142
28MP0008004_abnormal_stomach_pH1.98394732
29MP0001730_embryonic_growth_arrest1.97169607
30MP0003698_abnormal_male_reproductive1.89797019
31MP0004381_abnormal_hair_follicle1.86054141
32MP0003786_premature_aging1.83860191
33MP0001145_abnormal_male_reproductive1.79605218
34MP0009745_abnormal_behavioral_response1.78466351
35MP0005671_abnormal_response_to1.77820245
36MP0000350_abnormal_cell_proliferation1.77668976
37MP0005387_immune_system_phenotype1.75221828
38MP0001790_abnormal_immune_system1.75221828
39MP0002735_abnormal_chemical_nociception1.73347483
40MP0001697_abnormal_embryo_size1.72912892
41MP0002148_abnormal_hypersensitivity_rea1.70685668
42MP0005380_embryogenesis_phenotype1.70257544
43MP0001672_abnormal_embryogenesis/_devel1.70257544
44MP0003119_abnormal_digestive_system1.67279567
45MP0001800_abnormal_humoral_immune1.66966397
46MP0002084_abnormal_developmental_patter1.60850174
47MP0003303_peritoneal_inflammation1.60028184
48MP0003635_abnormal_synaptic_transmissio1.59918157
49MP0001501_abnormal_sleep_pattern1.59626277
50MP0003121_genomic_imprinting1.58487930
51MP0002160_abnormal_reproductive_system1.58373905
52MP0002064_seizures1.58050503
53MP0005448_abnormal_energy_balance1.57684170
54MP0002085_abnormal_embryonic_tissue1.56963766
55MP0010352_gastrointestinal_tract_polyps1.55668502
56MP0000653_abnormal_sex_gland1.54963909
57MP0002063_abnormal_learning/memory/cond1.52403727
58MP0003984_embryonic_growth_retardation1.47580079
59MP0003879_abnormal_hair_cell1.47487336
60MP0000015_abnormal_ear_pigmentation1.45821360
61MP0003724_increased_susceptibility_to1.45621679
62MP0002088_abnormal_embryonic_growth/wei1.43829662
63MP0004197_abnormal_fetal_growth/weight/1.43036445
64MP0005000_abnormal_immune_tolerance1.42966981
65MP0003172_abnormal_lysosome_physiology1.42615367
66MP0000537_abnormal_urethra_morphology1.41853421
67MP0003718_maternal_effect1.41644159
68MP0009785_altered_susceptibility_to1.40594123
69MP0003656_abnormal_erythrocyte_physiolo1.40285711
70MP0009046_muscle_twitch1.39387128
71MP0002723_abnormal_immune_serum1.39334005
72MP0000516_abnormal_urinary_system1.37933557
73MP0005367_renal/urinary_system_phenotyp1.37933557
74MP0005386_behavior/neurological_phenoty1.36670585
75MP0004924_abnormal_behavior1.36670585
76MP0002420_abnormal_adaptive_immunity1.35382007
77MP0001529_abnormal_vocalization1.33892326
78MP0002693_abnormal_pancreas_physiology1.33772347
79MP0004859_abnormal_synaptic_plasticity1.32490711
80MP0002080_prenatal_lethality1.30547362
81MP0001819_abnormal_immune_cell1.30376248
82MP0004484_altered_response_of1.30045890
83MP0002272_abnormal_nervous_system1.29629652
84MP0002572_abnormal_emotion/affect_behav1.28656640
85MP0003315_abnormal_perineum_morphology1.28115753
86MP0000685_abnormal_immune_system1.27550363
87MP0000703_abnormal_thymus_morphology1.26822135
88MP0005310_abnormal_salivary_gland1.24820175
89MP0002086_abnormal_extraembryonic_tissu1.24196003
90MP0003567_abnormal_fetal_cardiomyocyte1.22432603
91MP0002161_abnormal_fertility/fecundity1.21840095
92MP0001188_hyperpigmentation1.20000742
93MP0003787_abnormal_imprinting1.19717272
94MP0002909_abnormal_adrenal_gland1.19206275
95MP0003195_calcinosis1.17144455
96MP0010307_abnormal_tumor_latency1.16610867
97MP0003045_fibrosis1.14799919
98MP0008961_abnormal_basal_metabolism1.14412127
99MP0008872_abnormal_physiological_respon1.14153204
100MP0009115_abnormal_fat_cell1.13131686
101MP0002452_abnormal_antigen_presenting1.12859669
102MP0003806_abnormal_nucleotide_metabolis1.12845496
103MP0005389_reproductive_system_phenotype1.12775835
104MP0005076_abnormal_cell_differentiation1.12178525
105MP0003861_abnormal_nervous_system1.11907203
106MP0002067_abnormal_sensory_capabilities1.11496005
107MP0005464_abnormal_platelet_physiology1.10635056
108MP0005025_abnormal_response_to1.10147340
109MP0001873_stomach_inflammation1.10134800
110MP0002398_abnormal_bone_marrow1.08926901
111MP0005075_abnormal_melanosome_morpholog1.07388530
112MP0005174_abnormal_tail_pigmentation1.05729782
113MP0000716_abnormal_immune_system1.04644804
114MP0003136_yellow_coat_color1.04397864
115MP0000313_abnormal_cell_death1.03556079
116MP0001293_anophthalmia1.03401127
117MP0003941_abnormal_skin_development1.03346141
118MP0001944_abnormal_pancreas_morphology1.02608638
119MP0000371_diluted_coat_color1.02309753
120MP0000778_abnormal_nervous_system1.02098933
121MP0002405_respiratory_system_inflammati1.01977401
122MP0001986_abnormal_taste_sensitivity1.01854439
123MP0002733_abnormal_thermal_nociception1.01596383
124MP0002638_abnormal_pupillary_reflex1.01216893
125MP0004043_abnormal_pH_regulation1.01040567
126MP0005334_abnormal_fat_pad1.00611918
127MP0002419_abnormal_innate_immunity1.00042764
128MP0001502_abnormal_circadian_rhythm0.99474991
129MP0002078_abnormal_glucose_homeostasis0.98757776
130MP0002332_abnormal_exercise_endurance0.98731994
131MP0001286_abnormal_eye_development0.97792916
132MP0001970_abnormal_pain_threshold0.97175954
133MP0002722_abnormal_immune_system0.95904842
134MP0001905_abnormal_dopamine_level0.94486893
135MP0009672_abnormal_birth_weight0.94132466
136MP0003633_abnormal_nervous_system0.93732138
137MP0005423_abnormal_somatic_nervous0.92634537
138MP0002102_abnormal_ear_morphology0.91952098
139MP0000470_abnormal_stomach_morphology0.91339017
140MP0002229_neurodegeneration0.89199336
141MP0005167_abnormal_blood-brain_barrier0.88026740
142MP0004233_abnormal_muscle_weight0.87513126
143MP0001486_abnormal_startle_reflex0.86249305
144MP0005083_abnormal_biliary_tract0.86199638
145MP0004185_abnormal_adipocyte_glucose0.85812119
146MP0004742_abnormal_vestibular_system0.85210162
147MP0006072_abnormal_retinal_apoptosis0.84847453
148MP0001119_abnormal_female_reproductive0.84178944
149MP0000749_muscle_degeneration0.84120297
150MP0001835_abnormal_antigen_presentation0.84005756
151MP0003221_abnormal_cardiomyocyte_apopto0.83966920
152MP0002269_muscular_atrophy0.83469755
153MP0004084_abnormal_cardiac_muscle0.83374172
154MP0006035_abnormal_mitochondrial_morpho0.82979586
155MP0004142_abnormal_muscle_tone0.82757364
156MP0001440_abnormal_grooming_behavior0.82584117
157MP0003937_abnormal_limbs/digits/tail_de0.81770316
158MP0006082_CNS_inflammation0.81518587
159MP0009703_decreased_birth_body0.81447985
160MP0005623_abnormal_meninges_morphology0.81098766
161MP0009333_abnormal_splenocyte_physiolog0.80694003
162MP0005266_abnormal_metabolism0.80690331
163MP0002277_abnormal_respiratory_mucosa0.79825978
164MP0002734_abnormal_mechanical_nocicepti0.79688544
165MP0005394_taste/olfaction_phenotype0.79590351
166MP0005499_abnormal_olfactory_system0.79590351
167MP0002971_abnormal_brown_adipose0.78642072
168MP0000955_abnormal_spinal_cord0.78467463
169MP0002751_abnormal_autonomic_nervous0.77552174
170MP0003755_abnormal_palate_morphology0.76284735
171MP0002127_abnormal_cardiovascular_syste0.75932234
172MP0005248_abnormal_Harderian_gland0.75645603
173MP0006276_abnormal_autonomic_nervous0.73836548
174MP0002019_abnormal_tumor_incidence0.72913920
175MP0010030_abnormal_orbit_morphology0.71011141
176MP0006036_abnormal_mitochondrial_physio0.69499391
177MP0008789_abnormal_olfactory_epithelium0.69360526
178MP0000358_abnormal_cell_content/0.69293534
179MP0009697_abnormal_copulation0.67283651
180MP0002163_abnormal_gland_morphology0.66651021
181MP0004145_abnormal_muscle_electrophysio0.66446818
182MP0008995_early_reproductive_senescence0.65887417
183MP0002184_abnormal_innervation0.65498334
184MP0002081_perinatal_lethality0.63926285
185MP0001919_abnormal_reproductive_system0.63899864
186MP0002837_dystrophic_cardiac_calcinosis0.63562320
187MP0000678_abnormal_parathyroid_gland0.63341974
188MP0002152_abnormal_brain_morphology0.63312790
189MP0000432_abnormal_head_morphology0.63120822
190MP0002111_abnormal_tail_morphology0.60334907
191MP0002114_abnormal_axial_skeleton0.59122953
192MP0004270_analgesia0.57959196

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.32697444
2Ventricular fibrillation (HP:0001663)4.63499273
3Clumsiness (HP:0002312)4.02817045
4Stomatitis (HP:0010280)4.00071422
5Breast hypoplasia (HP:0003187)3.95012768
6Supernumerary spleens (HP:0009799)3.62997296
7Protruding tongue (HP:0010808)3.62645229
8Abnormality of the labia minora (HP:0012880)3.59971008
9Ependymoma (HP:0002888)3.46956330
10Carpal bone hypoplasia (HP:0001498)3.41735384
11Chronic mucocutaneous candidiasis (HP:0002728)3.31287281
12Recurrent cutaneous fungal infections (HP:0011370)3.31287281
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.25877078
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.23396935
15Febrile seizures (HP:0002373)3.16652134
16Medulloblastoma (HP:0002885)3.15396527
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.14514267
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08617555
19Prolonged QT interval (HP:0001657)3.04781045
20Rhabdomyosarcoma (HP:0002859)3.01772636
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.01067252
22Abnormality of the anterior horn cell (HP:0006802)2.91174629
23Degeneration of anterior horn cells (HP:0002398)2.91174629
24Impulsivity (HP:0100710)2.89310048
25Abnormality of the columella (HP:0009929)2.87480399
26Absent radius (HP:0003974)2.83467502
27Recurrent fungal infections (HP:0002841)2.83413403
28Agnosia (HP:0010524)2.83203238
29Patellar aplasia (HP:0006443)2.80001208
30Deep palmar crease (HP:0006191)2.76880973
31Postural instability (HP:0002172)2.76331737
32Chromsome breakage (HP:0040012)2.76190800
33Visual hallucinations (HP:0002367)2.74558429
34Biliary tract neoplasm (HP:0100574)2.74492524
35Hyporeflexia of lower limbs (HP:0002600)2.73555454
36Inability to walk (HP:0002540)2.71555936
37Colon cancer (HP:0003003)2.70132506
38Amyotrophic lateral sclerosis (HP:0007354)2.68948323
39Absent/shortened dynein arms (HP:0200106)2.68327461
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.68327461
41Hyperventilation (HP:0002883)2.66533066
42T lymphocytopenia (HP:0005403)2.61434987
43Increased cerebral lipofuscin (HP:0011813)2.61413183
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61164423
45Cerebral hypomyelination (HP:0006808)2.60571791
46Panhypogammaglobulinemia (HP:0003139)2.60274442
47Meckel diverticulum (HP:0002245)2.59487521
48Aplasia/Hypoplasia of the patella (HP:0006498)2.59457717
49Atrophy/Degeneration involving motor neurons (HP:0007373)2.59077059
50Aplasia involving forearm bones (HP:0009822)2.59034181
51Absent forearm bone (HP:0003953)2.59034181
52Nephroblastoma (Wilms tumor) (HP:0002667)2.58876229
53Astrocytoma (HP:0009592)2.56361790
54Abnormality of the astrocytes (HP:0100707)2.56361790
55Rib fusion (HP:0000902)2.55272441
56Abnormal EKG (HP:0003115)2.54617014
57Gaze-evoked nystagmus (HP:0000640)2.54422834
58Glioma (HP:0009733)2.54195546
59Premature ovarian failure (HP:0008209)2.49893519
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.48269524
61Abnormality of the ileum (HP:0001549)2.47969402
62Syncope (HP:0001279)2.46687110
63Neoplasm of the adrenal cortex (HP:0100641)2.42987719
64Abnormality of the lower motor neuron (HP:0002366)2.42885862
65Abnormality of eosinophils (HP:0001879)2.41966981
66Irregular epiphyses (HP:0010582)2.40385855
67Abnormality of chromosome stability (HP:0003220)2.38179832
68Focal seizures (HP:0007359)2.38037057
69Abnormality of T cell number (HP:0011839)2.37410081
70Progressive inability to walk (HP:0002505)2.37373742
71Neoplasm of the oral cavity (HP:0100649)2.37338312
72Oral leukoplakia (HP:0002745)2.36970355
73Absent thumb (HP:0009777)2.36447598
74Progressive cerebellar ataxia (HP:0002073)2.35897387
75Horseshoe kidney (HP:0000085)2.35549476
76Intellectual disability, progressive (HP:0006887)2.34199527
77Embryonal renal neoplasm (HP:0011794)2.32978907
78Optic neuritis (HP:0100653)2.32896333
79Retrobulbar optic neuritis (HP:0100654)2.32896333
80Thoracic kyphosis (HP:0002942)2.31780185
81Selective tooth agenesis (HP:0001592)2.29834607
82Thyroiditis (HP:0100646)2.29533235
83Broad-based gait (HP:0002136)2.29325317
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.29023966
85Global brain atrophy (HP:0002283)2.23014431
86Unsteady gait (HP:0002317)2.22445166
87Neoplasm of striated muscle (HP:0009728)2.22075690
88Progressive external ophthalmoplegia (HP:0000590)2.21500323
89Eosinophilia (HP:0001880)2.21245161
90Abnormality of abdominal situs (HP:0011620)2.17820346
91Abdominal situs inversus (HP:0003363)2.17820346
92Aplasia/hypoplasia of the humerus (HP:0006507)2.17609859
93Ulnar claw (HP:0001178)2.17303144
94Gastrointestinal infarctions (HP:0005244)2.15777753
95Type II lissencephaly (HP:0007260)2.14965094
96Abnormal lung lobation (HP:0002101)2.13476746
97Atonic seizures (HP:0010819)2.10322515
98Abnormality of T cells (HP:0002843)2.10292088
99Adenoma sebaceum (HP:0009720)2.10000880
100Angiofibromas (HP:0010615)2.10000880
101Abnormality of the preputium (HP:0100587)2.09961270
102Breast aplasia (HP:0100783)2.09452752
103Aplasia/Hypoplasia of the sternum (HP:0006714)2.08746442
104Bundle branch block (HP:0011710)2.08661934
105Encephalitis (HP:0002383)2.08267601
106Abnormal rod and cone electroretinograms (HP:0008323)2.07094434
107Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06835463
108Orchitis (HP:0100796)2.06667796
109Secondary amenorrhea (HP:0000869)2.05840984
110Abnormal respiratory motile cilium morphology (HP:0005938)2.04594369
111Abnormal respiratory epithelium morphology (HP:0012253)2.04594369
112Facial cleft (HP:0002006)2.03707208
113Large for gestational age (HP:0001520)2.01997148
114Abnormal biliary tract morphology (HP:0012440)2.01814422
115Ketosis (HP:0001946)2.00592630
116Absent speech (HP:0001344)2.00481667
117Supernumerary ribs (HP:0005815)1.99246883
118Breast carcinoma (HP:0003002)1.98758320
119Neoplasm of the colon (HP:0100273)1.98526140
120Abnormal spermatogenesis (HP:0008669)1.98521152
121Granulocytopenia (HP:0001913)1.98133807
122Supernumerary bones of the axial skeleton (HP:0009144)1.98125619
123Curly hair (HP:0002212)1.96741838
124Colitis (HP:0002583)1.96726368
125Neoplasm of the pancreas (HP:0002894)1.96455708
126Self-mutilation (HP:0000742)1.95959809
12711 pairs of ribs (HP:0000878)1.95605525
128Episodic fever (HP:0001954)1.94903406
129Abnormality of glycolipid metabolism (HP:0010969)1.94551548
130Abnormality of liposaccharide metabolism (HP:0010968)1.94551548
131Abnormality of glycosphingolipid metabolism (HP:0004343)1.94551548
132Frequent falls (HP:0002359)1.94237911
133Spinal muscular atrophy (HP:0007269)1.93265784
134Poor eye contact (HP:0000817)1.93238228
135Tongue fasciculations (HP:0001308)1.92274958
136Facial hemangioma (HP:0000329)1.91920933
137Abnormal number of incisors (HP:0011064)1.91644926
138Shawl scrotum (HP:0000049)1.91277261
139Hyperlipoproteinemia (HP:0010980)1.89682718
140Exercise-induced myalgia (HP:0003738)1.88979277
141Premature graying of hair (HP:0002216)1.88541734
142Basal cell carcinoma (HP:0002671)1.88230599
143Keratoconjunctivitis (HP:0001096)1.88085966
144Dysmetric saccades (HP:0000641)1.87682175
145Aplasia/Hypoplasia of the breasts (HP:0010311)1.87516649
146Polydipsia (HP:0001959)1.85743311
147Abnormal drinking behavior (HP:0030082)1.85743311
148Missing ribs (HP:0000921)1.85664231
149Autoimmune thrombocytopenia (HP:0001973)1.85448256
150Autoimmune hemolytic anemia (HP:0001890)1.84268504
151Rough bone trabeculation (HP:0100670)1.84187938
152Cellular immunodeficiency (HP:0005374)1.83556653
153Widely spaced teeth (HP:0000687)1.83159423
154Hematochezia (HP:0002573)1.82941642
155Fair hair (HP:0002286)1.82687660
156Testicular neoplasm (HP:0010788)1.82513809
157Leukocytosis (HP:0001974)1.82471779
158Abnormality of incisor morphology (HP:0011063)1.81609114
159Metaphyseal cupping (HP:0003021)1.81479002
160Duplicated collecting system (HP:0000081)1.81308046
161Recurrent skin infections (HP:0001581)1.81051116
162Sloping forehead (HP:0000340)1.80990439
163Abnormality of T cell physiology (HP:0011840)1.80753094
164Abnormal respiratory motile cilium physiology (HP:0012261)1.79872304
165Dialeptic seizures (HP:0011146)1.79799023
166Asplenia (HP:0001746)1.79370760
167Myositis (HP:0100614)1.78821427
168Urinary bladder sphincter dysfunction (HP:0002839)1.77734175
169Bone marrow hypocellularity (HP:0005528)1.77649816
170Small intestinal stenosis (HP:0012848)1.77556600
171Duodenal stenosis (HP:0100867)1.77556600
172Mild short stature (HP:0003502)1.77412431
173Stereotypic behavior (HP:0000733)1.76523527
174Germ cell neoplasia (HP:0100728)1.76496061
175Absence seizures (HP:0002121)1.76244943
176Small epiphyses (HP:0010585)1.75874529
177Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75556391
178Absent epiphyses (HP:0010577)1.75556391
179Calf muscle hypertrophy (HP:0008981)1.75108257
180Tracheoesophageal fistula (HP:0002575)1.74725075
181Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73925867
182Ankle clonus (HP:0011448)1.73692749
183Inappropriate behavior (HP:0000719)1.73633437
184Ovarian neoplasm (HP:0100615)1.73072569
185Lissencephaly (HP:0001339)1.72762741
186Congenital malformation of the right heart (HP:0011723)1.72206564
187Double outlet right ventricle (HP:0001719)1.72206564
188Hyperthyroidism (HP:0000836)1.72118141
189Albinism (HP:0001022)1.71192735
190Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71109078
191Generalized hypopigmentation of hair (HP:0011358)1.70610042
192Genetic anticipation (HP:0003743)1.70246598
193Abnormality of DNA repair (HP:0003254)1.70125198
194Hemoptysis (HP:0002105)1.69600302
195Inflammation of the large intestine (HP:0002037)1.69566012
196Recurrent bacterial skin infections (HP:0005406)1.68851792
197Keratoconjunctivitis sicca (HP:0001097)1.67385709
198Recurrent viral infections (HP:0004429)1.67210199
199Hypothermia (HP:0002045)1.66830331
200Abnormality of the pons (HP:0007361)1.66470442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.49171845
2PNCK4.03379613
3CDC73.89730027
4FRK3.51740476
5WEE13.22442562
6BUB13.08277442
7PLK43.01771907
8TTK2.98002104
9MARK32.94179175
10SRPK12.89403485
11IRAK22.53163484
12MARK12.49874869
13NTRK32.39069209
14ZAK2.35752371
15PDK32.35279145
16PDK42.35279145
17PRKD32.19347772
18CAMKK22.03779844
19TAOK32.01564683
20EPHA21.98304729
21TLK11.96875545
22STK38L1.95769837
23EIF2AK11.93340912
24IRAK41.92473019
25PLK11.91835203
26PLK31.81913922
27CDK121.80473434
28NEK11.77180549
29PDK21.76473183
30TSSK61.74303122
31ADRBK21.67800182
32MAP2K31.67321469
33SGK21.65038253
34AKT31.64758012
35SGK2231.63479250
36SGK4941.63479250
37LATS21.58946478
38OBSCN1.58485913
39CAMKK11.54111735
40IRAK11.52548251
41ACVR1B1.52531803
42DAPK21.52291739
43PLK21.47811509
44GRK61.43906744
45AURKA1.41408155
46RIPK41.36564798
47DYRK31.34388141
48CAMK1D1.34358170
49SGK31.33563495
50ATR1.31916872
51DYRK21.29036894
52TRIB31.28354221
53TESK11.26927554
54PASK1.26819699
55NTRK21.26574437
56EIF2AK31.25723152
57CHEK21.24862419
58CDK71.23966825
59TXK1.23081278
60NLK1.22580238
61MAP4K11.21836498
62FGFR21.20058906
63CHEK11.17629433
64PHKG11.12042150
65PHKG21.12042150
66MAP3K11.11790149
67AURKB1.10220428
68MKNK21.09723472
69NEK21.09137151
70TNK21.08077465
71BTK1.07164216
72BRAF1.03932190
73ATM1.03751944
74CAMK1G0.97902505
75MARK20.96396101
76LATS10.96244398
77PRKCI0.96159901
78IKBKE0.95823597
79NME10.95024422
80TAOK10.94081337
81IKBKB0.91148446
82BRSK20.90313523
83ZAP700.90091010
84MAPK120.88622198
85CDK20.86839067
86VRK10.84771160
87SYK0.84289398
88SCYL20.83593679
89MINK10.83024268
90MKNK10.81788325
91MAP2K70.78461488
92CLK10.76989752
93PDK10.75641834
94SIK20.74709551
95EEF2K0.73899599
96WNK10.73183237
97EIF2AK20.72474031
98MAP3K90.72305525
99BRSK10.71993587
100PRKCQ0.70387174
101STK110.70334999
102PAK30.70255415
103KSR10.69770839
104FES0.69627701
105TYRO30.69527873
106CAMK10.69396942
107EPHA40.69049576
108CDK10.68664753
109BLK0.67207420
110STK380.66419923
111RPS6KA60.66306989
112MAP3K40.65605433
113MAP3K80.64747724
114CAMK40.64674820
115PRPF4B0.64164880
116PDPK10.63257245
117PAK40.61799882
118CSNK1E0.60447031
119MAP3K110.60164834
120CASK0.60147506
121ALK0.60051500
122NEK60.59274279
123RPS6KB20.59067554
124ITK0.57938207
125HCK0.57887728
126MAPKAPK30.57142172
127GRK10.56524271
128MAP3K60.55533099
129CSNK2A20.55429722
130BMPR1B0.55193743
131BRD40.55103894
132BMPR20.54978104
133PRKD20.54588053
134PAK60.54170619
135MAP3K30.53665057
136PRKDC0.53569368
137HIPK20.53380255
138NME20.51848895
139DAPK10.51521139
140FGFR30.51519894
141CHUK0.50996717
142RPS6KB10.50693896
143ADRBK10.50331594
144STK40.49823298
145IRAK30.49620167
146CSNK2A10.48052677
147RET0.47934815
148MELK0.47905538
149CDK30.47904642
150RPS6KC10.47731429
151RPS6KL10.47731429
152PBK0.47498495
153CSNK1A1L0.47046265
154STK160.46986968
155DYRK1A0.46866978
156WNK40.46638547
157MAP2K40.45875892
158GRK50.45189032
159CDK50.45122147
160TEC0.45093868
161LIMK10.44346037
162ICK0.43219062
163TAOK20.42393699
164FGR0.42233725
165PIM10.42173181
166SGK10.42051991
167ABL20.41998632
168CSNK1G30.41903242
169BCR0.41798560
170CSNK1G20.41595258
171MAP3K50.41584690
172PKN20.41560528
173ERBB30.40286279
174MAP2K60.40116245
175CSNK1D0.39924840
176MAPK130.39595511
177MAPK100.39079486
178STK30.38837553
179CDK180.37790315
180PRKCG0.37256222
181CDK11A0.36896903
182CDK150.35339823
183CDK140.34059164
184CDK80.33592569

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.40894850
2Mismatch repair_Homo sapiens_hsa034304.19255726
3DNA replication_Homo sapiens_hsa030304.10123241
4RNA polymerase_Homo sapiens_hsa030203.68535464
5RNA transport_Homo sapiens_hsa030133.60000525
6Spliceosome_Homo sapiens_hsa030403.12026641
7Proteasome_Homo sapiens_hsa030502.99233424
8Basal transcription factors_Homo sapiens_hsa030222.83605698
9Fanconi anemia pathway_Homo sapiens_hsa034602.79856051
10Cell cycle_Homo sapiens_hsa041102.78906920
11Nucleotide excision repair_Homo sapiens_hsa034202.78253316
12Homologous recombination_Homo sapiens_hsa034402.76438074
13One carbon pool by folate_Homo sapiens_hsa006702.56614731
14Base excision repair_Homo sapiens_hsa034102.50932738
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32677164
16* mRNA surveillance pathway_Homo sapiens_hsa030152.29511447
17Pyrimidine metabolism_Homo sapiens_hsa002402.29077065
18RNA degradation_Homo sapiens_hsa030182.19387292
19Ribosome_Homo sapiens_hsa030102.16274932
20T cell receptor signaling pathway_Homo sapiens_hsa046601.96764895
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83468397
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83271571
23Non-homologous end-joining_Homo sapiens_hsa034501.75940505
24Oocyte meiosis_Homo sapiens_hsa041141.74778691
25B cell receptor signaling pathway_Homo sapiens_hsa046621.65393731
26Olfactory transduction_Homo sapiens_hsa047401.64598217
27Phototransduction_Homo sapiens_hsa047441.63582667
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62394185
29Huntingtons disease_Homo sapiens_hsa050161.57535284
30Dorso-ventral axis formation_Homo sapiens_hsa043201.48739815
31Purine metabolism_Homo sapiens_hsa002301.47369381
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46306808
33Oxytocin signaling pathway_Homo sapiens_hsa049211.45752810
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45258164
35Osteoclast differentiation_Homo sapiens_hsa043801.40612596
36Circadian entrainment_Homo sapiens_hsa047131.39887339
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.39390308
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.35928594
39Nitrogen metabolism_Homo sapiens_hsa009101.34409145
40VEGF signaling pathway_Homo sapiens_hsa043701.29882867
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29790756
42Vitamin B6 metabolism_Homo sapiens_hsa007501.28574632
43Calcium signaling pathway_Homo sapiens_hsa040201.26782244
44Sulfur relay system_Homo sapiens_hsa041221.25857496
45Primary immunodeficiency_Homo sapiens_hsa053401.25439212
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23980091
47p53 signaling pathway_Homo sapiens_hsa041151.23102131
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22940279
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22637259
50Cholinergic synapse_Homo sapiens_hsa047251.21987206
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21493895
52Type II diabetes mellitus_Homo sapiens_hsa049301.20752230
53* Sphingolipid signaling pathway_Homo sapiens_hsa040711.20132668
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19950315
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18966260
56Morphine addiction_Homo sapiens_hsa050321.17213687
57Renin secretion_Homo sapiens_hsa049241.14872956
58Parkinsons disease_Homo sapiens_hsa050121.14410551
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.14166080
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.13127077
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12271091
62Insulin secretion_Homo sapiens_hsa049111.12182515
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12142896
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.11677089
65Pancreatic secretion_Homo sapiens_hsa049721.09306476
66Platelet activation_Homo sapiens_hsa046111.09076489
67TNF signaling pathway_Homo sapiens_hsa046681.09048108
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07251870
69Oxidative phosphorylation_Homo sapiens_hsa001901.07151098
70Circadian rhythm_Homo sapiens_hsa047101.06418172
71Epstein-Barr virus infection_Homo sapiens_hsa051691.06044554
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05065889
73Estrogen signaling pathway_Homo sapiens_hsa049151.03543507
74Acute myeloid leukemia_Homo sapiens_hsa052211.02996654
75GnRH signaling pathway_Homo sapiens_hsa049121.02466948
76* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99849737
77Glioma_Homo sapiens_hsa052140.97225768
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.96356427
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95881683
80Linoleic acid metabolism_Homo sapiens_hsa005910.95761423
81Gastric acid secretion_Homo sapiens_hsa049710.92554697
82Measles_Homo sapiens_hsa051620.89005110
83Glutamatergic synapse_Homo sapiens_hsa047240.88483557
84Chemokine signaling pathway_Homo sapiens_hsa040620.87854168
85Salivary secretion_Homo sapiens_hsa049700.86950879
86* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85078547
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84431183
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83575981
89Non-small cell lung cancer_Homo sapiens_hsa052230.83437720
90cAMP signaling pathway_Homo sapiens_hsa040240.81554918
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80776947
92Systemic lupus erythematosus_Homo sapiens_hsa053220.79710193
93ABC transporters_Homo sapiens_hsa020100.78789297
94Apoptosis_Homo sapiens_hsa042100.78129769
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77719344
96Prolactin signaling pathway_Homo sapiens_hsa049170.77598611
97GABAergic synapse_Homo sapiens_hsa047270.77141249
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76354774
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76287999
100Tuberculosis_Homo sapiens_hsa051520.75718047
101* Hippo signaling pathway_Homo sapiens_hsa043900.75647526
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75420408
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.75087019
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74569655
105Ether lipid metabolism_Homo sapiens_hsa005650.73593325
106Hepatitis B_Homo sapiens_hsa051610.71918450
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71664362
108Cardiac muscle contraction_Homo sapiens_hsa042600.71654163
109Inositol phosphate metabolism_Homo sapiens_hsa005620.71433958
110Choline metabolism in cancer_Homo sapiens_hsa052310.71230389
111Insulin signaling pathway_Homo sapiens_hsa049100.70721764
112Hedgehog signaling pathway_Homo sapiens_hsa043400.70568469
113Alzheimers disease_Homo sapiens_hsa050100.69786510
114Insulin resistance_Homo sapiens_hsa049310.69696443
115Long-term potentiation_Homo sapiens_hsa047200.67871730
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.67481210
117Alcoholism_Homo sapiens_hsa050340.67419998
118Basal cell carcinoma_Homo sapiens_hsa052170.66572006
119Nicotine addiction_Homo sapiens_hsa050330.65774736
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63824087
121Viral carcinogenesis_Homo sapiens_hsa052030.62816649
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.62794123
123Ovarian steroidogenesis_Homo sapiens_hsa049130.62764892
124Collecting duct acid secretion_Homo sapiens_hsa049660.61932541
125Protein export_Homo sapiens_hsa030600.61591936
126Ras signaling pathway_Homo sapiens_hsa040140.60242057
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59588796
128HTLV-I infection_Homo sapiens_hsa051660.58719337
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57012231
130Biosynthesis of amino acids_Homo sapiens_hsa012300.56357199
131Thyroid cancer_Homo sapiens_hsa052160.55461473
132TGF-beta signaling pathway_Homo sapiens_hsa043500.54022111
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53737259
134MicroRNAs in cancer_Homo sapiens_hsa052060.52602637
135Carbon metabolism_Homo sapiens_hsa012000.51240655
136Amphetamine addiction_Homo sapiens_hsa050310.49492448
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48905396
138Wnt signaling pathway_Homo sapiens_hsa043100.47693187
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44904046
140Pyruvate metabolism_Homo sapiens_hsa006200.44085169
141Colorectal cancer_Homo sapiens_hsa052100.44019672
142Antigen processing and presentation_Homo sapiens_hsa046120.42471697
143Synaptic vesicle cycle_Homo sapiens_hsa047210.41540353
144Fructose and mannose metabolism_Homo sapiens_hsa000510.40738534
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39501191
146Taste transduction_Homo sapiens_hsa047420.37629208
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32871052
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32727115
149mTOR signaling pathway_Homo sapiens_hsa041500.32233362
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32146022
151* Tight junction_Homo sapiens_hsa045300.31469852
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30936839
153Selenocompound metabolism_Homo sapiens_hsa004500.29202470
154Pentose phosphate pathway_Homo sapiens_hsa000300.29082453
155Glucagon signaling pathway_Homo sapiens_hsa049220.28353821
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.27284282
157FoxO signaling pathway_Homo sapiens_hsa040680.26597939
158Galactose metabolism_Homo sapiens_hsa000520.26274061
159* Dopaminergic synapse_Homo sapiens_hsa047280.25868266
160Regulation of autophagy_Homo sapiens_hsa041400.25279979
161Serotonergic synapse_Homo sapiens_hsa047260.24294476
162Herpes simplex infection_Homo sapiens_hsa051680.22897283
163Renal cell carcinoma_Homo sapiens_hsa052110.21255584
164Endometrial cancer_Homo sapiens_hsa052130.20768681
165Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19970148
166HIF-1 signaling pathway_Homo sapiens_hsa040660.18837076
167Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18619706
168Metabolic pathways_Homo sapiens_hsa011000.18143379
169Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17266602
170Melanogenesis_Homo sapiens_hsa049160.15750705
171Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15336633
172Melanoma_Homo sapiens_hsa052180.14897061
173Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14870940
174Adherens junction_Homo sapiens_hsa045200.12181833
175Prostate cancer_Homo sapiens_hsa052150.11963583
176Pathways in cancer_Homo sapiens_hsa052000.11789298
177Glutathione metabolism_Homo sapiens_hsa004800.11625643
178Long-term depression_Homo sapiens_hsa047300.10249811
179Axon guidance_Homo sapiens_hsa043600.08314446
180MAPK signaling pathway_Homo sapiens_hsa040100.08227410
181Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08163620
182Notch signaling pathway_Homo sapiens_hsa043300.06028068
183ErbB signaling pathway_Homo sapiens_hsa040120.04753222

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