PPP2CB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.84421791
2protein localization to endosome (GO:0036010)4.58350594
3cytoskeletal anchoring at plasma membrane (GO:0007016)4.09658351
4synaptic vesicle maturation (GO:0016188)4.07745304
5locomotory exploration behavior (GO:0035641)3.90499385
6stress fiber assembly (GO:0043149)3.85054284
7regulation of clathrin-mediated endocytosis (GO:2000369)3.65108801
8regulation of translational termination (GO:0006449)3.61076368
9sodium ion export (GO:0071436)3.59586900
10activation of protein kinase A activity (GO:0034199)3.55215329
11regulation of early endosome to late endosome transport (GO:2000641)3.52063029
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48428693
13synaptic vesicle exocytosis (GO:0016079)3.48261842
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47852989
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46183460
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45321126
17postsynaptic membrane organization (GO:0001941)3.42539879
18regulation of hippo signaling (GO:0035330)3.39588802
19response to nerve growth factor (GO:1990089)3.39061721
20cellular response to nerve growth factor stimulus (GO:1990090)3.39061721
21regulation of synaptic vesicle exocytosis (GO:2000300)3.37664750
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.34432120
23cerebellar granule cell differentiation (GO:0021707)3.31347804
24potassium ion homeostasis (GO:0055075)3.27207117
25glutamate secretion (GO:0014047)3.26411934
26dendritic spine morphogenesis (GO:0060997)3.22322643
27axon ensheathment in central nervous system (GO:0032291)3.22162121
28central nervous system myelination (GO:0022010)3.22162121
29neuron recognition (GO:0008038)3.21132356
30establishment of nucleus localization (GO:0040023)3.20420359
31cell communication by electrical coupling (GO:0010644)3.17167994
32presynaptic membrane organization (GO:0097090)3.15252365
33apical protein localization (GO:0045176)3.14269302
34negative regulation of microtubule polymerization (GO:0031115)3.13627552
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.11436441
36clathrin coat assembly (GO:0048268)3.10411901
37mating behavior (GO:0007617)3.09453094
38regulation of Rac protein signal transduction (GO:0035020)3.06877235
39presynaptic membrane assembly (GO:0097105)3.03158782
40adherens junction assembly (GO:0034333)3.01169729
41cellular sodium ion homeostasis (GO:0006883)3.00492747
42pre-miRNA processing (GO:0031054)2.98000870
43establishment of apical/basal cell polarity (GO:0035089)2.97634323
44G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97309449
45ionotropic glutamate receptor signaling pathway (GO:0035235)2.94276944
46signal complex assembly (GO:0007172)2.94256782
47cellular potassium ion homeostasis (GO:0030007)2.94120503
48regulation of synapse structural plasticity (GO:0051823)2.91059627
49neuromuscular process controlling balance (GO:0050885)2.90803453
50vesicle transport along microtubule (GO:0047496)2.90311653
51potassium ion import (GO:0010107)2.87606822
52neuron cell-cell adhesion (GO:0007158)2.86582041
53proline transport (GO:0015824)2.85989723
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85360143
55hippo signaling (GO:0035329)2.83859081
56negative regulation of cell killing (GO:0031342)2.83812681
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83812681
58exploration behavior (GO:0035640)2.81793058
59SMAD protein complex assembly (GO:0007183)2.80209956
60neuronal action potential propagation (GO:0019227)2.78920235
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78128943
62regulation of glutamate receptor signaling pathway (GO:1900449)2.74993719
63polarized epithelial cell differentiation (GO:0030859)2.74118718
64protein localization to synapse (GO:0035418)2.74062184
65regulation of ARF GTPase activity (GO:0032312)2.73063001
66vocalization behavior (GO:0071625)2.73052407
67establishment of monopolar cell polarity (GO:0061162)2.73044411
68establishment or maintenance of monopolar cell polarity (GO:0061339)2.73044411
69nerve growth factor signaling pathway (GO:0038180)2.72964120
70neurotransmitter-gated ion channel clustering (GO:0072578)2.72874362
71neuronal ion channel clustering (GO:0045161)2.72792804
72regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72355048
73cerebellar Purkinje cell layer development (GO:0021680)2.69090569
74auditory behavior (GO:0031223)2.68581301
75hypotonic response (GO:0006971)2.68573307
76regulation of dendritic spine morphogenesis (GO:0061001)2.65916347
77amino acid import (GO:0043090)2.63872923
78dendrite morphogenesis (GO:0048813)2.63169449
79NLS-bearing protein import into nucleus (GO:0006607)2.62867246
80negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.62587497
81regulation of translational fidelity (GO:0006450)2.62123294
82regulation of nucleobase-containing compound transport (GO:0032239)2.61756320
83regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.61483205
84positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.61483205
85peptidyl-threonine modification (GO:0018210)2.59977129
86peptidyl-lysine dimethylation (GO:0018027)2.59903888
87cell communication involved in cardiac conduction (GO:0086065)2.59385075
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58702459
89positive regulation of dendritic spine development (GO:0060999)2.56931004
90positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.56642470
91peptidyl-threonine phosphorylation (GO:0018107)2.56097959
92organelle transport along microtubule (GO:0072384)2.54789751
93positive regulation of synapse maturation (GO:0090129)2.54008054
94axon extension (GO:0048675)2.53329245
95focal adhesion assembly (GO:0048041)2.51272453
96cell-substrate adherens junction assembly (GO:0007045)2.51272453
97L-amino acid import (GO:0043092)2.51002106
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.50419681
99negative regulation of adherens junction organization (GO:1903392)2.50390859
100negative regulation of focal adhesion assembly (GO:0051895)2.50390859
101negative regulation of cell junction assembly (GO:1901889)2.50390859
102asymmetric protein localization (GO:0008105)2.49757022
103regulation of RNA export from nucleus (GO:0046831)2.49000188
104glucocorticoid receptor signaling pathway (GO:0042921)2.47963255
105cerebral cortex radially oriented cell migration (GO:0021799)2.47701194
106neurotransmitter secretion (GO:0007269)2.47302836
107heterochromatin organization (GO:0070828)2.46656598
108regulation of synaptic vesicle transport (GO:1902803)2.46317957
109actin filament bundle assembly (GO:0051017)2.46056062
110actin filament bundle organization (GO:0061572)2.46056062
111positive regulation of nitric-oxide synthase activity (GO:0051000)2.45892103
112negative regulation of GTPase activity (GO:0034260)2.45688737
113negative regulation of GTP catabolic process (GO:0033125)2.45688737
114establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.45414297
115cortical actin cytoskeleton organization (GO:0030866)2.45173680
116negative regulation of fatty acid transport (GO:2000192)2.44481239
117glial cell proliferation (GO:0014009)2.44284870
118receptor catabolic process (GO:0032801)2.43001894
119synaptic transmission, glutamatergic (GO:0035249)2.41957348
120cell migration in hindbrain (GO:0021535)2.41943720
121regulation of ARF protein signal transduction (GO:0032012)2.41729703
122localization within membrane (GO:0051668)2.41551585
123innervation (GO:0060384)2.41276554
124plasma membrane repair (GO:0001778)2.39751065
125cell adhesion mediated by integrin (GO:0033627)2.39717772
126establishment of mitochondrion localization (GO:0051654)2.39590865
127regulation of neuronal synaptic plasticity (GO:0048168)2.39339398
128epithelial cell-cell adhesion (GO:0090136)2.39024932
129positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.37571708
130positive regulation of fibroblast migration (GO:0010763)2.36417511
131response to auditory stimulus (GO:0010996)2.36371784
132labyrinthine layer blood vessel development (GO:0060716)2.36048960
133neurotransmitter transport (GO:0006836)2.35769784
134glutamate receptor signaling pathway (GO:0007215)2.34410560
135anterior/posterior axis specification, embryo (GO:0008595)2.34341735
136membrane repolarization (GO:0086009)2.34212287
137cytoplasmic mRNA processing body assembly (GO:0033962)2.33849496
138substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.33751555
139substrate-independent telencephalic tangential migration (GO:0021826)2.33751555
140axonal fasciculation (GO:0007413)2.33631940
141positive regulation of potassium ion transport (GO:0043268)2.33345100
142negative regulation of dendrite morphogenesis (GO:0050774)2.29493984
143gastrulation with mouth forming second (GO:0001702)2.29315431
144regulation of synaptic plasticity (GO:0048167)2.26352191
145regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.25333122
146membrane assembly (GO:0071709)2.25069519
147negative regulation of synaptic transmission, GABAergic (GO:0032229)2.24862658
148regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23805011
149neuron projection extension (GO:1990138)2.21769771
150negative regulation of catenin import into nucleus (GO:0035414)2.20392357
151suckling behavior (GO:0001967)2.18397136
152mechanosensory behavior (GO:0007638)2.18336695
153positive regulation of potassium ion transmembrane transport (GO:1901381)2.17371857
154positive regulation of synapse assembly (GO:0051965)2.16737919
155regulation of neurotransmitter levels (GO:0001505)2.16092568
156paraxial mesoderm development (GO:0048339)2.15763388
157dendritic spine organization (GO:0097061)2.11203401
158regulation of vesicle fusion (GO:0031338)2.10189303
159neuron-neuron synaptic transmission (GO:0007270)2.09921749
160synaptic vesicle endocytosis (GO:0048488)2.09819655
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.09805114
162establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.09658236
163mitochondrion transport along microtubule (GO:0047497)2.09658236
164regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.08310233
165regulation of neurotransmitter secretion (GO:0046928)2.07548066
166astrocyte differentiation (GO:0048708)2.05618811
167neuromuscular synaptic transmission (GO:0007274)2.04399583
168cochlea development (GO:0090102)2.02751102
169regulation of synapse assembly (GO:0051963)2.02635407
170neuron remodeling (GO:0016322)2.02614462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.90052513
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.38666797
3ZNF263_19887448_ChIP-Seq_K562_Human2.83201063
4TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.78254412
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.68339911
6SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.41727625
7KDM2B_26808549_Chip-Seq_DND41_Human2.33625610
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29895838
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25261825
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24868190
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23950983
12KDM2B_26808549_Chip-Seq_K562_Human2.21155720
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.14825683
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11076513
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.10838078
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10688508
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07975332
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.07803306
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.05674498
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.05646158
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04683829
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.03755363
23P300_27058665_Chip-Seq_ZR-75-30cells_Human2.02625814
24GBX2_23144817_ChIP-Seq_PC3_Human1.98249524
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93405805
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93046003
27CLOCK_20551151_ChIP-Seq_293T_Human1.92153062
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.88955401
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.87626715
30EZH2_22144423_ChIP-Seq_EOC_Human1.83428422
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82064820
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.80984553
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.77794632
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76665915
35MYC_22102868_ChIP-Seq_BL_Human1.72533381
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70367033
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69902833
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66076374
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66060967
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.63680687
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.61096430
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60621936
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58971385
44ATF3_27146783_Chip-Seq_COLON_Human1.58248028
45TCF7_22412390_ChIP-Seq_EML_Mouse1.57890750
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55770877
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.55202218
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.54981459
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52123161
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.51667559
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.51104773
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50742748
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50152150
54RACK7_27058665_Chip-Seq_MCF-7_Human1.49802661
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49623205
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49124411
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49046636
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47982389
59CREB1_26743006_Chip-Seq_LNCaP_Human1.47303293
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47054420
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46115990
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.44971610
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44918789
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44394596
65LXR_22292898_ChIP-Seq_THP-1_Human1.44020723
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43739226
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40648732
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40238769
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38456932
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.37969749
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.35673315
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.34939087
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31312623
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30518465
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30406628
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28618915
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28314807
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27532206
79* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27016726
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24657635
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23874210
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23083860
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21963922
84ZNF274_21170338_ChIP-Seq_K562_Hela1.20563660
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20023839
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18431316
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18431316
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18357087
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17897270
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17546054
91TP53_16413492_ChIP-PET_HCT116_Human1.16875770
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16628168
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16628168
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16628168
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.16335525
96KLF5_25053715_ChIP-Seq_YYC3_Human1.16196268
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16157472
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16045664
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15384401
100SMAD4_21799915_ChIP-Seq_A2780_Human1.14420545
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13881038
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13881038
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13865000
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13687652
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13595832
106TP53_18474530_ChIP-ChIP_U2OS_Human1.13290722
107MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12811834
108CHD1_26751641_Chip-Seq_LNCaP_Human1.11825193
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11707952
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11158203
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11042182
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10828099
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09172745
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08946616
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.08584161
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08180614
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07648394
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07033150
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06788384
120* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06221380
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06197629
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05212718
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05162671
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.03888696
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02715551
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01480875
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.00660958
128DROSHA_22980978_ChIP-Seq_HELA_Human1.00503349
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00094013
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99801527
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99127850
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99025059
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98172584
134RNF2_27304074_Chip-Seq_NSC_Mouse0.97554139
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97519215
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97256896
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96095243
138JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95089307
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95025760
140REST_21632747_ChIP-Seq_MESCs_Mouse0.94944191
141* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94480640
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94122979
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93225659
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92934207
145RNF2_27304074_Chip-Seq_ESCs_Mouse0.92884298
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92860562
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.92641545
148VDR_21846776_ChIP-Seq_THP-1_Human0.92371227
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.91633885
150SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91541535
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.91477993
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90987683
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.90212114
154REST_18959480_ChIP-ChIP_MESCs_Mouse0.90067259
155PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90035603
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89868637
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89426681
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88543957
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88532706
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87084328
161AR_19668381_ChIP-Seq_PC3_Human0.87071559
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.86566739
163AR_21572438_ChIP-Seq_LNCaP_Human0.86446249
164* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85634074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.28184805
2MP0010234_abnormal_vibrissa_follicle3.92591267
3MP0003705_abnormal_hypodermis_morpholog3.86288007
4MP0005623_abnormal_meninges_morphology3.61761806
5MP0003303_peritoneal_inflammation3.10039029
6MP0000537_abnormal_urethra_morphology2.82774925
7MP0010352_gastrointestinal_tract_polyps2.74676660
8MP0003635_abnormal_synaptic_transmissio2.47638672
9MP0005076_abnormal_cell_differentiation2.32993882
10MP0004270_analgesia2.32592986
11MP0005423_abnormal_somatic_nervous2.19679318
12MP0004858_abnormal_nervous_system2.18029415
13MP0009053_abnormal_anal_canal2.02754526
14MP0002063_abnormal_learning/memory/cond2.02443506
15MP0004885_abnormal_endolymph2.02252306
16MP0003123_paternal_imprinting2.01495974
17MP0003329_amyloid_beta_deposits1.92449247
18MP0002877_abnormal_melanocyte_morpholog1.89760899
19MP0003300_gastrointestinal_ulcer1.84690555
20MP0005167_abnormal_blood-brain_barrier1.77647401
21MP0004185_abnormal_adipocyte_glucose1.76850557
22MP0003566_abnormal_cell_adhesion1.73879005
23MP0009780_abnormal_chondrocyte_physiolo1.71962968
24MP0000566_synostosis1.68872294
25MP0004272_abnormal_basement_membrane1.68466071
26MP0003880_abnormal_central_pattern1.62337688
27MP0001348_abnormal_lacrimal_gland1.61945222
28MP0003091_abnormal_cell_migration1.60630349
29MP0009379_abnormal_foot_pigmentation1.60008454
30MP0010368_abnormal_lymphatic_system1.59480163
31MP0002064_seizures1.58479229
32MP0005409_darkened_coat_color1.53095052
33MP0004811_abnormal_neuron_physiology1.52869633
34MP0009745_abnormal_behavioral_response1.49499656
35MP0009046_muscle_twitch1.48115545
36MP0001958_emphysema1.41566585
37MP0009278_abnormal_bone_marrow1.40189912
38MP0003879_abnormal_hair_cell1.32651811
39MP0008961_abnormal_basal_metabolism1.32423137
40MP0002653_abnormal_ependyma_morphology1.31765058
41MP0005187_abnormal_penis_morphology1.31680742
42MP0000534_abnormal_ureter_morphology1.30771652
43MP0000733_abnormal_muscle_development1.24715563
44MP0002733_abnormal_thermal_nociception1.23469881
45MP0002084_abnormal_developmental_patter1.23248715
46MP0003941_abnormal_skin_development1.23147900
47MP0001984_abnormal_olfaction1.22821000
48MP0004197_abnormal_fetal_growth/weight/1.22038723
49MP0001730_embryonic_growth_arrest1.21752378
50MP0003283_abnormal_digestive_organ1.21692676
51MP0003119_abnormal_digestive_system1.20214630
52MP0001502_abnormal_circadian_rhythm1.19036343
53MP0010307_abnormal_tumor_latency1.18402538
54MP0000579_abnormal_nail_morphology1.16772392
55MP0002557_abnormal_social/conspecific_i1.16114530
56MP0008569_lethality_at_weaning1.15997481
57MP0003690_abnormal_glial_cell1.15914673
58MP0001440_abnormal_grooming_behavior1.15794764
59MP0001968_abnormal_touch/_nociception1.14965942
60MP0002572_abnormal_emotion/affect_behav1.14940745
61MP0002822_catalepsy1.14423779
62MP0001849_ear_inflammation1.14249031
63MP0002067_abnormal_sensory_capabilities1.14037299
64MP0002909_abnormal_adrenal_gland1.13131283
65MP0000778_abnormal_nervous_system1.12804044
66MP0008438_abnormal_cutaneous_collagen1.11486964
67MP0003890_abnormal_embryonic-extraembry1.10902839
68MP0003122_maternal_imprinting1.10357660
69MP0004133_heterotaxia1.08350827
70MP0004924_abnormal_behavior1.06517783
71MP0005386_behavior/neurological_phenoty1.06517783
72MP0000462_abnormal_digestive_system1.06205495
73MP0002734_abnormal_mechanical_nocicepti1.05950724
74MP0003075_altered_response_to1.05422792
75MP0001970_abnormal_pain_threshold1.03956083
76MP0002086_abnormal_extraembryonic_tissu1.03646081
77MP0003861_abnormal_nervous_system0.99309391
78MP0002139_abnormal_hepatobiliary_system0.97710904
79MP0002736_abnormal_nociception_after0.97122539
80MP0008770_decreased_survivor_rate0.96936246
81MP0002796_impaired_skin_barrier0.96885863
82MP0002152_abnormal_brain_morphology0.96289660
83MP0004215_abnormal_myocardial_fiber0.95680668
84MP0003136_yellow_coat_color0.95254758
85MP0000013_abnormal_adipose_tissue0.94948965
86MP0001177_atelectasis0.94776784
87MP0004233_abnormal_muscle_weight0.94456310
88MP0003115_abnormal_respiratory_system0.93211964
89MP0003448_altered_tumor_morphology0.92896273
90MP0001188_hyperpigmentation0.92700705
91MP0000955_abnormal_spinal_cord0.91901097
92MP0000920_abnormal_myelination0.91731129
93MP0000604_amyloidosis0.90507385
94MP0005275_abnormal_skin_tensile0.90029636
95MP0003221_abnormal_cardiomyocyte_apopto0.89915445
96MP0003453_abnormal_keratinocyte_physiol0.88761332
97MP0000762_abnormal_tongue_morphology0.87795528
98MP0000747_muscle_weakness0.87694462
99MP0000026_abnormal_inner_ear0.87505353
100MP0002184_abnormal_innervation0.87371748
101MP0005257_abnormal_intraocular_pressure0.86551246
102MP0003633_abnormal_nervous_system0.86322064
103MP0000751_myopathy0.84616569
104MP0003868_abnormal_feces_composition0.84056287
105MP0001529_abnormal_vocalization0.83580767
106MP0006276_abnormal_autonomic_nervous0.83191711
107MP0002282_abnormal_trachea_morphology0.82791112
108MP0003634_abnormal_glial_cell0.82672497
109MP0002085_abnormal_embryonic_tissue0.82017448
110MP0003385_abnormal_body_wall0.81928731
111MP0001697_abnormal_embryo_size0.80918961
112MP0003632_abnormal_nervous_system0.80793051
113MP0003631_nervous_system_phenotype0.80502797
114MP0005166_decreased_susceptibility_to0.80239799
115MP0000350_abnormal_cell_proliferation0.80105350
116MP0002089_abnormal_postnatal_growth/wei0.79194206
117MP0001485_abnormal_pinna_reflex0.78690729
118MP0002925_abnormal_cardiovascular_devel0.77822865
119MP0002088_abnormal_embryonic_growth/wei0.77633355
120MP0001672_abnormal_embryogenesis/_devel0.77456186
121MP0005380_embryogenesis_phenotype0.77456186
122MP0002066_abnormal_motor_capabilities/c0.77404782
123MP0003984_embryonic_growth_retardation0.76531472
124MP0005595_abnormal_vascular_smooth0.76343380
125MP0002735_abnormal_chemical_nociception0.75098013
126MP0001299_abnormal_eye_distance/0.73057909
127MP0002896_abnormal_bone_mineralization0.73028069
128MP0001879_abnormal_lymphatic_vessel0.72550271
129MP0003121_genomic_imprinting0.72262594
130MP0002080_prenatal_lethality0.71772887
131MP0005023_abnormal_wound_healing0.71311999
132MP0004130_abnormal_muscle_cell0.70409446
133MP0010030_abnormal_orbit_morphology0.70120660
134MP0001501_abnormal_sleep_pattern0.70116991
135MP0002229_neurodegeneration0.69953247
136MP0001963_abnormal_hearing_physiology0.69813812
137MP0004043_abnormal_pH_regulation0.69444223
138MP0002882_abnormal_neuron_morphology0.68595270
139MP0003787_abnormal_imprinting0.68029308
140MP0002272_abnormal_nervous_system0.67962099
141MP0001943_abnormal_respiration0.67563873
142MP0004019_abnormal_vitamin_homeostasis0.67254484
143MP0003942_abnormal_urinary_system0.66905828
144MP0000516_abnormal_urinary_system0.66855896
145MP0005367_renal/urinary_system_phenotyp0.66855896
146MP0002249_abnormal_larynx_morphology0.66630741
147MP0001486_abnormal_startle_reflex0.66214767

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)3.50630982
2Insidious onset (HP:0003587)3.50630982
3Visual hallucinations (HP:0002367)3.38100916
4Limb dystonia (HP:0002451)3.34422499
5Myokymia (HP:0002411)3.26721294
6Cerebral inclusion bodies (HP:0100314)3.21837035
7Achilles tendon contracture (HP:0001771)2.92164284
8Cerebral aneurysm (HP:0004944)2.84834295
9Shallow orbits (HP:0000586)2.79843099
10Papilledema (HP:0001085)2.64258818
11Resting tremor (HP:0002322)2.60926072
12Aplasia involving bones of the upper limbs (HP:0009823)2.60683071
13Aplasia of the phalanges of the hand (HP:0009802)2.60683071
14Aplasia involving bones of the extremities (HP:0009825)2.60683071
15Abnormality of the Achilles tendon (HP:0005109)2.59773057
16Genu recurvatum (HP:0002816)2.59563264
17Protrusio acetabuli (HP:0003179)2.56750241
18Buphthalmos (HP:0000557)2.52056651
19Ankyloglossia (HP:0010296)2.50241183
20Torticollis (HP:0000473)2.47651160
21Abnormality of the lower motor neuron (HP:0002366)2.46913851
22Upper limb amyotrophy (HP:0009129)2.44446531
23Distal upper limb amyotrophy (HP:0007149)2.44446531
24Focal seizures (HP:0007359)2.42387772
25Urinary urgency (HP:0000012)2.41753159
26Febrile seizures (HP:0002373)2.41194730
27Mitral valve prolapse (HP:0001634)2.41064777
28Insomnia (HP:0100785)2.39239253
29Subacute progressive viral hepatitis (HP:0006572)2.39072188
30Vascular tortuosity (HP:0004948)2.34391478
31Abnormality of oral frenula (HP:0000190)2.34376766
32Split foot (HP:0001839)2.31992585
33Amyotrophic lateral sclerosis (HP:0007354)2.29379495
34Pointed chin (HP:0000307)2.29180463
35Focal dystonia (HP:0004373)2.28571406
36Abnormal eating behavior (HP:0100738)2.25953922
37Hand muscle atrophy (HP:0009130)2.25234813
38Dysmetric saccades (HP:0000641)2.23527788
39Arterial tortuosity (HP:0005116)2.22496119
40Turricephaly (HP:0000262)2.20021153
41Supranuclear gaze palsy (HP:0000605)2.19725047
42Action tremor (HP:0002345)2.19299556
43Vertebral arch anomaly (HP:0008438)2.19155214
44Atonic seizures (HP:0010819)2.18243845
45Megalencephaly (HP:0001355)2.17797846
46Hypercortisolism (HP:0001578)2.17615086
47Focal motor seizures (HP:0011153)2.17569921
48Rapidly progressive (HP:0003678)2.17147177
49Hyperacusis (HP:0010780)2.16607530
50Apathy (HP:0000741)2.12762916
51Impaired vibration sensation in the lower limbs (HP:0002166)2.09108565
52Annular pancreas (HP:0001734)2.08512157
53Coronal craniosynostosis (HP:0004440)2.07966970
54Macroorchidism (HP:0000053)2.07841476
55Generalized tonic-clonic seizures (HP:0002069)2.07239912
56Depression (HP:0000716)2.06085645
57Urinary bladder sphincter dysfunction (HP:0002839)2.03435860
58Pseudobulbar signs (HP:0002200)2.02110449
59Enlarged penis (HP:0000040)2.02098852
60Craniofacial dystonia (HP:0012179)2.01285748
61Obstructive sleep apnea (HP:0002870)2.00594016
62Diminished motivation (HP:0000745)1.99483567
63Bronchomalacia (HP:0002780)1.99093287
64Akinesia (HP:0002304)1.98222668
65Neurofibrillary tangles (HP:0002185)1.97941817
66Broad metatarsal (HP:0001783)1.96985803
67Absent/shortened dynein arms (HP:0200106)1.96002169
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.96002169
69Hallux valgus (HP:0001822)1.94356574
70Deep palmar crease (HP:0006191)1.94139250
71Epileptic encephalopathy (HP:0200134)1.93827377
72Ulnar bowing (HP:0003031)1.92132982
73Abnormality of the corticospinal tract (HP:0002492)1.91343602
74Absence seizures (HP:0002121)1.90278940
75Dilatation of the ascending aorta (HP:0005111)1.90185446
76Deviation of the hallux (HP:0010051)1.90183912
77Premature rupture of membranes (HP:0001788)1.89551833
78Hyperparathyroidism (HP:0000843)1.87702792
79Hammertoe (HP:0001765)1.87322883
80Neonatal short-limb short stature (HP:0008921)1.86765886
81Rectal prolapse (HP:0002035)1.85284791
82Spastic gait (HP:0002064)1.84436418
83Mutism (HP:0002300)1.84245645
84Fibroma (HP:0010614)1.84050388
85Lower limb asymmetry (HP:0100559)1.81600833
86Hemiparesis (HP:0001269)1.81256119
87Ankle contracture (HP:0006466)1.80444504
88Neuronal loss in central nervous system (HP:0002529)1.80123510
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79602224
90Abnormality of dentin (HP:0010299)1.77486942
91Sleep apnea (HP:0010535)1.77469890
92Diplopia (HP:0000651)1.77412170
93Abnormality of binocular vision (HP:0011514)1.77412170
94Disinhibition (HP:0000734)1.77206067
95Global brain atrophy (HP:0002283)1.76085433
96Polyphagia (HP:0002591)1.75556040
97Bundle branch block (HP:0011710)1.74317393
98Abnormality of the diencephalon (HP:0010662)1.73893673
99Overriding aorta (HP:0002623)1.73791376
100Hemiplegia (HP:0002301)1.73786418
101Asymmetry of the thorax (HP:0001555)1.73417279
102Impaired smooth pursuit (HP:0007772)1.73396791
103Overgrowth (HP:0001548)1.73052758
104Fibrous tissue neoplasm (HP:0012316)1.72914813
105Bowel diverticulosis (HP:0005222)1.72862368
106Cortical dysplasia (HP:0002539)1.72765857
107Abnormal ciliary motility (HP:0012262)1.72114894
108Cutaneous melanoma (HP:0012056)1.71793530
109Neoplasm of the peripheral nervous system (HP:0100007)1.70528678
110Postural tremor (HP:0002174)1.70236094
111Abnormal respiratory motile cilium morphology (HP:0005938)1.69232996
112Abnormal respiratory epithelium morphology (HP:0012253)1.69232996
113Intention tremor (HP:0002080)1.68700404
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.67852536
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67852536
116Genetic anticipation (HP:0003743)1.67102954
117Difficulty climbing stairs (HP:0003551)1.67034823
118Lower limb muscle weakness (HP:0007340)1.66662176
119Atrophic scars (HP:0001075)1.66428284
120Truncal ataxia (HP:0002078)1.65532080
121Renal duplication (HP:0000075)1.65016037
122Striae distensae (HP:0001065)1.64567235
123Anxiety (HP:0000739)1.64544410
124Amblyopia (HP:0000646)1.64357309
125Inappropriate behavior (HP:0000719)1.63733041
126Arnold-Chiari malformation (HP:0002308)1.63597148
127Dysmetria (HP:0001310)1.62996537
128Congenital glaucoma (HP:0001087)1.62725209
129Abnormal respiratory motile cilium physiology (HP:0012261)1.62711136
130Ankle clonus (HP:0011448)1.61762986
131Nuclear cataract (HP:0100018)1.61259191
132Abnormality of the labia minora (HP:0012880)1.60601919
133Bladder carcinoma (HP:0002862)1.60370215
134Bladder neoplasm (HP:0009725)1.60370215
135Spastic diplegia (HP:0001264)1.60309732
136Hypoventilation (HP:0002791)1.59089667
137Scanning speech (HP:0002168)1.58905835
138Long toe (HP:0010511)1.58856672
139Abnormal social behavior (HP:0012433)1.58448450
140Impaired social interactions (HP:0000735)1.58448450
141Progressive cerebellar ataxia (HP:0002073)1.57705932
142Asymmetric growth (HP:0100555)1.57465856
143Back pain (HP:0003418)1.57449296
144Intellectual disability, profound (HP:0002187)1.57135072
145Lower limb amyotrophy (HP:0007210)1.56796916
146Drooling (HP:0002307)1.56414778
147Spastic tetraparesis (HP:0001285)1.54634131
148Thickened helices (HP:0000391)1.52974492
149Morphological abnormality of the pyramidal tract (HP:0002062)1.52919934
150Bladder diverticulum (HP:0000015)1.52272291
151Rhinitis (HP:0012384)1.51346680
152Epileptiform EEG discharges (HP:0011182)1.48214174
153Postural instability (HP:0002172)1.46469231
154Gait imbalance (HP:0002141)1.45386279
155Dialeptic seizures (HP:0011146)1.44750827
156Heterochromia iridis (HP:0001100)1.44443870
157Fetal akinesia sequence (HP:0001989)1.44382858
158Hyperextensible skin (HP:0000974)1.43188186
159Vertebral clefting (HP:0008428)1.43059211
160Mitral regurgitation (HP:0001653)1.42216905
161Dysdiadochokinesis (HP:0002075)1.42215495
162Cutaneous finger syndactyly (HP:0010554)1.42031269
163Peripheral hypomyelination (HP:0007182)1.39802470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.47342629
2TRIB33.41635258
3CASK3.22881600
4PKN23.20887077
5KSR22.78193376
6ALK2.24637448
7MAP3K22.22624321
8TYRO32.19859068
9SCYL22.09623376
10LATS22.02734188
11EEF2K1.90978487
12PAK61.87925799
13RIPK11.86228710
14PRKD31.84788050
15MAP3K41.75034634
16BMX1.66539149
17PHKG21.64102029
18PHKG11.64102029
19NTRK31.59309492
20TESK11.55924414
21MINK11.53382260
22PDGFRA1.48521009
23KSR11.46744406
24RET1.45019703
25PTK61.44357432
26MARK11.41934031
27DMPK1.41480351
28DDR21.38866910
29RIPK41.37127173
30PAK41.36942005
31FGR1.36939200
32TTN1.36222337
33STK381.32953945
34SIK21.29258300
35ARAF1.27450266
36PNCK1.25679873
37NTRK11.25282560
38MAP2K41.24734392
39DAPK21.24690022
40MOS1.24324627
41TNIK1.23224754
42EPHA21.22561226
43CAMK2B1.21655226
44MET1.18442641
45PRKCG1.17251430
46ICK1.17007875
47STK38L1.15013804
48LIMK11.14679349
49PTK21.13578774
50LRRK21.11688441
51EPHA41.10108794
52SGK4941.09926482
53SGK2231.09926482
54STK241.09083333
55CAMK2G1.07163790
56CDK121.05527522
57CAMKK11.04693834
58LMTK21.02251919
59TAOK11.01777746
60FER1.00654439
61UHMK10.98021874
62STK110.96535307
63PTK2B0.94746182
64CDK140.93959220
65EPHB10.93205257
66CDK60.91789758
67CAMK2D0.91690364
68PINK10.91220064
69MAP3K120.90783741
70CAMK2A0.89960039
71GRK60.89044258
72ABL20.88248360
73NEK10.87586081
74ILK0.87491007
75CDK150.87435545
76PAK30.85191078
77PDGFRB0.82814822
78MAPK130.82406786
79NTRK20.82346580
80PKN10.82199778
81SGK20.81468038
82CDK50.81110903
83TIE10.80788706
84CDK180.80072566
85ROCK10.79776495
86ERBB40.79642344
87PLK20.79359030
88MAP3K100.78300426
89MAPK150.78138699
90CDK11A0.77680269
91SGK30.77471038
92DAPK10.77140067
93PAK20.75627311
94PDK40.74612934
95PDK30.74612934
96TSSK60.74523288
97FES0.71674515
98RAF10.70500013
99DYRK1A0.69733580
100LATS10.67375240
101STK390.62723512
102FGFR10.62686750
103PDK10.62283828
104MYLK0.61792205
105BCR0.60697021
106SGK10.60653369
107PDPK10.60327176
108NEK20.58740593
109PRKCE0.58096903
110WNK10.57578256
111GRK50.56982328
112MTOR0.55307353
113CAMK10.55302460
114DAPK30.54701302
115PRKCH0.54370217
116MAP2K10.51858654
117ERBB30.51606967
118EPHB20.51277751
119EGFR0.50614371
120CDK190.48490315
121MAPK100.47582470
122WNK40.47415933
123CSNK1G20.46950778
124STK30.46477655
125MAP3K60.46176165
126ROCK20.45749793
127PRKG20.44364409
128MAP2K70.43561639
129FYN0.43496956
130MAP3K30.43473052
131GSK3A0.42991444
132MAP3K10.42918016
133CAMK1G0.41403264
134DYRK20.41138452
135FGFR20.40873336
136ERBB20.40819261
137MAP3K80.40607892
138RPS6KA30.40384351
139PRKCZ0.38969272
140FRK0.38820240
141PRKG10.37335946
142MELK0.37264867
143CSK0.37134704
144BRAF0.36012897
145CSNK1E0.35792559
146SIK10.35701614
147MARK20.35470249
148STK100.35041637
149SRC0.32870323

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.23646409
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12552958
3Synaptic vesicle cycle_Homo sapiens_hsa047211.90796748
4Glioma_Homo sapiens_hsa052141.73351408
5Estrogen signaling pathway_Homo sapiens_hsa049151.72983782
6Nitrogen metabolism_Homo sapiens_hsa009101.63955300
7VEGF signaling pathway_Homo sapiens_hsa043701.60525184
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59690399
9Gastric acid secretion_Homo sapiens_hsa049711.53271869
10Bile secretion_Homo sapiens_hsa049761.52669022
11Amphetamine addiction_Homo sapiens_hsa050311.47556242
12Gap junction_Homo sapiens_hsa045401.47014011
13Renal cell carcinoma_Homo sapiens_hsa052111.45263311
14* Dopaminergic synapse_Homo sapiens_hsa047281.44650475
15Vitamin B6 metabolism_Homo sapiens_hsa007501.43580280
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39882846
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36345381
18mTOR signaling pathway_Homo sapiens_hsa041501.36225737
19GnRH signaling pathway_Homo sapiens_hsa049121.35080978
20Salivary secretion_Homo sapiens_hsa049701.34514274
21* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33504952
22Dorso-ventral axis formation_Homo sapiens_hsa043201.32183255
23Circadian entrainment_Homo sapiens_hsa047131.29532651
24GABAergic synapse_Homo sapiens_hsa047271.28127944
25Endometrial cancer_Homo sapiens_hsa052131.26947575
26* Long-term depression_Homo sapiens_hsa047301.25527525
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.25152569
28Proteoglycans in cancer_Homo sapiens_hsa052051.24476724
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24071924
30Bladder cancer_Homo sapiens_hsa052191.23878684
31Oxytocin signaling pathway_Homo sapiens_hsa049211.23446084
32Chronic myeloid leukemia_Homo sapiens_hsa052201.21958407
33Olfactory transduction_Homo sapiens_hsa047401.20705472
34Focal adhesion_Homo sapiens_hsa045101.20485929
35Renin secretion_Homo sapiens_hsa049241.20298523
36Arginine biosynthesis_Homo sapiens_hsa002201.19783002
37Glutamatergic synapse_Homo sapiens_hsa047241.19448527
38Melanogenesis_Homo sapiens_hsa049161.18849835
39ErbB signaling pathway_Homo sapiens_hsa040121.18502618
40Histidine metabolism_Homo sapiens_hsa003401.18138326
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18062326
42Cholinergic synapse_Homo sapiens_hsa047251.17048582
43* Oocyte meiosis_Homo sapiens_hsa041141.15167615
44* Tight junction_Homo sapiens_hsa045301.14951015
45Axon guidance_Homo sapiens_hsa043601.14670524
46Non-small cell lung cancer_Homo sapiens_hsa052231.14110581
47Adherens junction_Homo sapiens_hsa045201.14100069
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13379291
49Colorectal cancer_Homo sapiens_hsa052101.12064911
50Nicotine addiction_Homo sapiens_hsa050331.11141652
51* Hippo signaling pathway_Homo sapiens_hsa043901.08921777
52Morphine addiction_Homo sapiens_hsa050321.07452932
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.06800217
54Amoebiasis_Homo sapiens_hsa051461.06214162
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05909577
56Arginine and proline metabolism_Homo sapiens_hsa003301.05442120
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03911465
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01940442
59Cocaine addiction_Homo sapiens_hsa050301.00975223
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99597434
61Endocytosis_Homo sapiens_hsa041440.98926330
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98766786
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96723824
64beta-Alanine metabolism_Homo sapiens_hsa004100.95491694
65PPAR signaling pathway_Homo sapiens_hsa033200.94948690
66Rap1 signaling pathway_Homo sapiens_hsa040150.94210641
67Serotonergic synapse_Homo sapiens_hsa047260.91711733
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91578865
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91035627
70Type II diabetes mellitus_Homo sapiens_hsa049300.90457926
71Pancreatic cancer_Homo sapiens_hsa052120.90120240
72Thyroid hormone synthesis_Homo sapiens_hsa049180.89481418
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.89267128
74Cardiac muscle contraction_Homo sapiens_hsa042600.88813650
75Phenylalanine metabolism_Homo sapiens_hsa003600.88604374
76Protein digestion and absorption_Homo sapiens_hsa049740.87724918
77Mineral absorption_Homo sapiens_hsa049780.87405616
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86893527
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86722166
80Thyroid cancer_Homo sapiens_hsa052160.86325215
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.86278697
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85379115
83MAPK signaling pathway_Homo sapiens_hsa040100.85310766
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85193837
85Vibrio cholerae infection_Homo sapiens_hsa051100.84860925
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83006821
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82917892
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82408999
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82163002
90Platelet activation_Homo sapiens_hsa046110.81734331
91Pancreatic secretion_Homo sapiens_hsa049720.80038402
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78538268
93Insulin secretion_Homo sapiens_hsa049110.76685095
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76429870
95Calcium signaling pathway_Homo sapiens_hsa040200.75358344
96MicroRNAs in cancer_Homo sapiens_hsa052060.75282336
97Shigellosis_Homo sapiens_hsa051310.75106886
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74893675
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74428788
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74302362
101Dilated cardiomyopathy_Homo sapiens_hsa054140.73581565
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73552122
103Pyruvate metabolism_Homo sapiens_hsa006200.72887926
104Salmonella infection_Homo sapiens_hsa051320.72483084
105Choline metabolism in cancer_Homo sapiens_hsa052310.72290861
106* Sphingolipid signaling pathway_Homo sapiens_hsa040710.72099202
107Insulin signaling pathway_Homo sapiens_hsa049100.71624583
108Wnt signaling pathway_Homo sapiens_hsa043100.69971998
109Small cell lung cancer_Homo sapiens_hsa052220.69858938
110Prion diseases_Homo sapiens_hsa050200.69275000
111ECM-receptor interaction_Homo sapiens_hsa045120.69076135
112Circadian rhythm_Homo sapiens_hsa047100.68881410
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67671860
114cAMP signaling pathway_Homo sapiens_hsa040240.66833318
115HIF-1 signaling pathway_Homo sapiens_hsa040660.66727201
116Collecting duct acid secretion_Homo sapiens_hsa049660.65962117
117Hedgehog signaling pathway_Homo sapiens_hsa043400.65246277
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65015169
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.64924176
120Melanoma_Homo sapiens_hsa052180.64041040
121Chemokine signaling pathway_Homo sapiens_hsa040620.63288436
122Taste transduction_Homo sapiens_hsa047420.63192939
123Folate biosynthesis_Homo sapiens_hsa007900.62648241
124Sulfur metabolism_Homo sapiens_hsa009200.61992537
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61874446
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.61498571
127Basal cell carcinoma_Homo sapiens_hsa052170.60077052
128Prolactin signaling pathway_Homo sapiens_hsa049170.59872605
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59441187
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58841023
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57659153
132Sphingolipid metabolism_Homo sapiens_hsa006000.57406313
133Ras signaling pathway_Homo sapiens_hsa040140.56857358
134Glucagon signaling pathway_Homo sapiens_hsa049220.56404728
135Caffeine metabolism_Homo sapiens_hsa002320.54040122
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52156195
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51063033
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50932281
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47345172
140Chemical carcinogenesis_Homo sapiens_hsa052040.46963314
141Retinol metabolism_Homo sapiens_hsa008300.46291428
142Fatty acid degradation_Homo sapiens_hsa000710.45778349
143Propanoate metabolism_Homo sapiens_hsa006400.44828831
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44706961

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