PPP1R2P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.87413223
2chromosome condensation (GO:0030261)9.59343716
3DNA packaging (GO:0006323)9.34382686
4sperm capacitation (GO:0048240)9.14057432
5plasma membrane fusion (GO:0045026)8.89831225
6spermatid nucleus differentiation (GO:0007289)8.02202947
7spermatid development (GO:0007286)7.95194980
8single strand break repair (GO:0000012)7.91405882
9microtubule depolymerization (GO:0007019)7.79062985
10sperm-egg recognition (GO:0035036)7.43005500
11rRNA methylation (GO:0031167)7.04326005
12binding of sperm to zona pellucida (GO:0007339)6.90255389
13protein polyglutamylation (GO:0018095)6.76039624
14sexual reproduction (GO:0019953)6.64804694
15microtubule polymerization or depolymerization (GO:0031109)6.56515578
16protein targeting to Golgi (GO:0000042)6.52714915
17negative regulation of inclusion body assembly (GO:0090084)6.50109805
18multicellular organism reproduction (GO:0032504)6.49172459
19calcium ion-dependent exocytosis (GO:0017156)6.39393730
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.35786235
21reproduction (GO:0000003)6.30540652
22establishment of protein localization to Golgi (GO:0072600)6.26648519
23cell-cell recognition (GO:0009988)6.15548976
24retrograde transport, vesicle recycling within Golgi (GO:0000301)6.05475653
25spermatogenesis (GO:0007283)6.05130745
26male gamete generation (GO:0048232)6.03162385
27axonemal dynein complex assembly (GO:0070286)5.98562306
28rRNA modification (GO:0000154)5.98359453
29phosphatidylethanolamine metabolic process (GO:0046337)5.87539143
30microtubule severing (GO:0051013)5.76540983
31centriole replication (GO:0007099)5.67026517
32gamete generation (GO:0007276)5.52176143
33cellular ketone body metabolic process (GO:0046950)5.23411859
34positive regulation of Rab GTPase activity (GO:0032851)5.14744719
35regulation of Rab GTPase activity (GO:0032313)5.14744719
36regulation of cilium movement (GO:0003352)5.11747104
37RNA destabilization (GO:0050779)5.03798647
38centriole assembly (GO:0098534)5.01566932
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91113981
40regulation of somitogenesis (GO:0014807)4.89774838
41cell wall macromolecule catabolic process (GO:0016998)4.88442826
42motile cilium assembly (GO:0044458)4.84678045
43protein localization to Golgi apparatus (GO:0034067)4.69170050
44regulation of transcription involved in cell fate commitment (GO:0060850)4.66964754
45cell wall macromolecule metabolic process (GO:0044036)4.66002520
46chromatin silencing (GO:0006342)4.61325612
47ketone body metabolic process (GO:1902224)4.61262314
48regulation of inclusion body assembly (GO:0090083)4.60984426
49germ cell development (GO:0007281)4.55470876
50cilium or flagellum-dependent cell motility (GO:0001539)4.53942070
51single fertilization (GO:0007338)4.51342940
52regulation of centriole replication (GO:0046599)4.43235066
53multicellular organismal reproductive process (GO:0048609)4.42692322
54cellular process involved in reproduction in multicellular organism (GO:0022412)4.36781525
55nucleus organization (GO:0006997)4.15752529
56negative regulation of Rho protein signal transduction (GO:0035024)4.10833103
57regulation of microtubule-based movement (GO:0060632)4.07191391
58seminiferous tubule development (GO:0072520)4.00322229
59coenzyme catabolic process (GO:0009109)3.89122423
60organic cation transport (GO:0015695)3.87015299
61fertilization (GO:0009566)3.84808372
62musculoskeletal movement (GO:0050881)3.84143919
63multicellular organismal movement (GO:0050879)3.84143919
64epithelial cilium movement (GO:0003351)3.74249147
65polyamine biosynthetic process (GO:0006596)3.56188576
66glycerol ether metabolic process (GO:0006662)3.47925428
67positive regulation of action potential (GO:0045760)3.32364945
68somite rostral/caudal axis specification (GO:0032525)3.30555033
69cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.29071336
70regulation of interleukin-13 production (GO:0032656)3.27801247
71cerebral cortex neuron differentiation (GO:0021895)3.27015382
72histone H3-K9 demethylation (GO:0033169)3.26789491
73response to acidic pH (GO:0010447)3.25635635
74cilium movement (GO:0003341)3.25589440
75cranial nerve morphogenesis (GO:0021602)3.22549242
76peptidyl-threonine dephosphorylation (GO:0035970)3.21936634
77ether metabolic process (GO:0018904)3.20415990
78regulation of T-helper 2 cell differentiation (GO:0045628)3.20198341
79negative regulation of gene expression, epigenetic (GO:0045814)3.12865464
80microtubule nucleation (GO:0007020)3.11535718
81homeostasis of number of cells within a tissue (GO:0048873)3.08002466
82cellular response to pH (GO:0071467)3.06375042
83nucleosome disassembly (GO:0006337)3.06258466
84protein-DNA complex disassembly (GO:0032986)3.06258466
85multicellular organismal development (GO:0007275)2.97679857
86DNA conformation change (GO:0071103)2.96934387
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.95346892
88cell recognition (GO:0008037)2.95177230
89tooth mineralization (GO:0034505)2.95139527
90mitotic G1 DNA damage checkpoint (GO:0031571)2.93867129
91mesenchymal cell differentiation involved in renal system development (GO:2001012)2.93022180
92mesenchymal cell differentiation involved in kidney development (GO:0072161)2.93022180
93membrane protein intracellular domain proteolysis (GO:0031293)2.91143661
94protein depolymerization (GO:0051261)2.90810070
95DNA methylation involved in gamete generation (GO:0043046)2.82237675
96piRNA metabolic process (GO:0034587)2.81174025
97male meiosis I (GO:0007141)2.78390206
98fusion of sperm to egg plasma membrane (GO:0007342)11.7345149
99acrosome reaction (GO:0007340)11.7063880
100sperm motility (GO:0030317)11.5671200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.64767951
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88981812
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.50785821
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40896885
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.40896885
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20406727
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15315121
8CBP_20019798_ChIP-Seq_JUKART_Human2.10449634
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.10449634
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.08602751
11EZH2_22144423_ChIP-Seq_EOC_Human2.07557261
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06171281
13ERA_21632823_ChIP-Seq_H3396_Human2.02627004
14DROSHA_22980978_ChIP-Seq_HELA_Human1.90719884
15EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.89939399
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87945372
17RAC3_21632823_ChIP-Seq_H3396_Human1.87508287
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.86878887
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86281806
20NANOG_20526341_ChIP-Seq_ESCs_Human1.84319987
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.83742497
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.79499847
23FUS_26573619_Chip-Seq_HEK293_Human1.74978764
24CTCF_27219007_Chip-Seq_Bcells_Human1.73040405
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68230281
26BCL6_27268052_Chip-Seq_Bcells_Human1.67917500
27TDRD3_21172665_ChIP-Seq_MCF-7_Human1.67844401
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66630944
29TAF2_19829295_ChIP-Seq_ESCs_Human1.65826280
30E2F1_20622854_ChIP-Seq_HELA_Human1.63671459
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61826225
32SMC4_20622854_ChIP-Seq_HELA_Human1.59801345
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.59791257
34MYC_19829295_ChIP-Seq_ESCs_Human1.58487760
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56726644
36ER_23166858_ChIP-Seq_MCF-7_Human1.56021146
37PHF8_20622854_ChIP-Seq_HELA_Human1.54108358
38BCOR_27268052_Chip-Seq_Bcells_Human1.53306320
39P68_20966046_ChIP-Seq_HELA_Human1.53220255
40CTCF_20526341_ChIP-Seq_ESCs_Human1.51917508
41OCT4_20526341_ChIP-Seq_ESCs_Human1.47864311
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47489127
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44587194
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.43127409
45TP63_22573176_ChIP-Seq_HFKS_Human1.42642405
46HNFA_21074721_ChIP-Seq_CACO-2_Human1.39892202
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.38037404
48CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36426358
49P300_27268052_Chip-Seq_Bcells_Human1.36331909
50CBX2_22325352_ChIP-Seq_293T-Rex_Human1.35956558
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35714367
52AR_25329375_ChIP-Seq_VCAP_Human1.35444964
53RUNX_20019798_ChIP-Seq_JUKART_Human1.35000220
54RBPJ_21746931_ChIP-Seq_IB4_Human1.34548384
55LXR_22292898_ChIP-Seq_THP-1_Human1.32118556
56CEBPB_22108803_ChIP-Seq_LS180_Human1.31396444
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30829535
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29103758
59ETV1_20927104_ChIP-Seq_GIST48_Human1.29082407
60P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28537393
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28136771
62* ARNT_22903824_ChIP-Seq_MCF-7_Human1.27252304
63ERG_20517297_ChIP-Seq_VCAP_Human1.27167892
64SMAD3_21741376_ChIP-Seq_ESCs_Human1.25637647
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24869847
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23874848
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23731661
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23554477
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.21234717
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19538867
71RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18711508
72NFYB_21822215_ChIP-Seq_K562_Human1.17746670
73* TP53_18474530_ChIP-ChIP_U2OS_Human1.17611866
74SA1_27219007_Chip-Seq_Bcells_Human1.16152533
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16002081
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15793623
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.15487868
78P53_21459846_ChIP-Seq_SAOS-2_Human1.15212256
79TBL1_22424771_ChIP-Seq_293T_Human1.14644813
80PHF8_20622853_ChIP-Seq_HELA_Human1.11568083
81GATA6_21074721_ChIP-Seq_CACO-2_Human1.10393584
82TAF15_26573619_Chip-Seq_HEK293_Human1.09853413
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08697235
84* P300_19829295_ChIP-Seq_ESCs_Human1.07490528
85* SMRT_27268052_Chip-Seq_Bcells_Human1.05260688
86ZNF274_21170338_ChIP-Seq_K562_Hela1.04227986
87* SMAD3_21741376_ChIP-Seq_EPCs_Human1.03623870
88HOXB7_26014856_ChIP-Seq_BT474_Human1.03372131
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02753157
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02154376
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01364436
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.00292882
93NFYA_21822215_ChIP-Seq_K562_Human1.00180809
94SOX2_19829295_ChIP-Seq_ESCs_Human0.99021672
95NANOG_19829295_ChIP-Seq_ESCs_Human0.99021672
96KLF5_25053715_ChIP-Seq_YYC3_Human0.97673276
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97582553
98GF1_26923725_Chip-Seq_HPCs_Mouse0.96806557
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.96246550
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95526156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.22224259
2MP0003878_abnormal_ear_physiology5.22224259
3MP0005670_abnormal_white_adipose4.67194795
4MP0003698_abnormal_male_reproductive4.45473055
5MP0001929_abnormal_gametogenesis3.83968711
6MP0001348_abnormal_lacrimal_gland3.20390710
7MP0000678_abnormal_parathyroid_gland2.77200759
8MP0002161_abnormal_fertility/fecundity2.52192160
9MP0003718_maternal_effect2.26371315
10MP0003646_muscle_fatigue2.10713368
11MP0002234_abnormal_pharynx_morphology2.00286308
12MP0005410_abnormal_fertilization12.4304239
13MP0005423_abnormal_somatic_nervous1.96100242
14MP0002132_abnormal_respiratory_system1.95341672
15MP0003011_delayed_dark_adaptation1.83401428
16MP0002210_abnormal_sex_determination1.68633716
17MP0005310_abnormal_salivary_gland1.66111968
18MP0002249_abnormal_larynx_morphology1.66102216
19MP0005379_endocrine/exocrine_gland_phen1.60539110
20MP0001485_abnormal_pinna_reflex1.49490072
21MP0009053_abnormal_anal_canal1.47215897
22MP0001145_abnormal_male_reproductive1.41263326
23MP0001486_abnormal_startle_reflex1.38831165
24MP0002282_abnormal_trachea_morphology1.34901251
25MP0000653_abnormal_sex_gland1.34027849
26MP0002822_catalepsy1.28111726
27MP0008877_abnormal_DNA_methylation1.27430614
28MP0000534_abnormal_ureter_morphology1.27083040
29MP0004510_myositis1.26948684
30MP0005451_abnormal_body_composition1.20001364
31MP0001765_abnormal_ion_homeostasis1.16503069
32MP0002127_abnormal_cardiovascular_syste1.15877887
33MP0004742_abnormal_vestibular_system1.14974198
34MP0005395_other_phenotype1.11167684
35MP0002735_abnormal_chemical_nociception1.10006934
36MP0004859_abnormal_synaptic_plasticity1.09222857
37MP0002138_abnormal_hepatobiliary_system1.06693041
38MP0003879_abnormal_hair_cell1.03814956
39MP0001963_abnormal_hearing_physiology1.02396185
40MP0001968_abnormal_touch/_nociception0.98807185
41MP0005248_abnormal_Harderian_gland0.94821595
42MP0000026_abnormal_inner_ear0.94716371
43MP0000681_abnormal_thyroid_gland0.92913635
44MP0000955_abnormal_spinal_cord0.90943525
45MP0002229_neurodegeneration0.89690344
46MP0001873_stomach_inflammation0.83411586
47MP0009115_abnormal_fat_cell0.79094408
48MP0001879_abnormal_lymphatic_vessel0.77573577
49MP0000049_abnormal_middle_ear0.75218664
50MP0008569_lethality_at_weaning0.73809630
51MP0004484_altered_response_of0.72778803
52MP0005666_abnormal_adipose_tissue0.72225706
53MP0008961_abnormal_basal_metabolism0.69671062
54MP0002067_abnormal_sensory_capabilities0.69223767
55MP0005551_abnormal_eye_electrophysiolog0.68648251
56MP0005367_renal/urinary_system_phenotyp0.67051179
57MP0000516_abnormal_urinary_system0.67051179
58MP0002733_abnormal_thermal_nociception0.65652334
59MP0005375_adipose_tissue_phenotype0.64821115
60MP0005636_abnormal_mineral_homeostasis0.64175494
61MP0004085_abnormal_heartbeat0.64068139
62MP0003137_abnormal_impulse_conducting0.63132821
63MP0002557_abnormal_social/conspecific_i0.62762975
64MP0001666_abnormal_nutrient_absorption0.62133955
65MP0001905_abnormal_dopamine_level0.61118983
66MP0002653_abnormal_ependyma_morphology0.59987168
67MP0000003_abnormal_adipose_tissue0.56249131
68MP0005623_abnormal_meninges_morphology0.56245139
69MP0000613_abnormal_salivary_gland0.55865024
70MP0002272_abnormal_nervous_system0.53934934
71MP0000249_abnormal_blood_vessel0.52703612
72MP0003119_abnormal_digestive_system0.51624611
73MP0005253_abnormal_eye_physiology0.51059880
74MP0003699_abnormal_female_reproductive0.50108402
75MP0002734_abnormal_mechanical_nocicepti0.49813206
76MP0009745_abnormal_behavioral_response0.49767664
77MP0005647_abnormal_sex_gland0.49296527
78MP0005167_abnormal_blood-brain_barrier0.48508476
79MP0002572_abnormal_emotion/affect_behav0.48033208
80MP0003077_abnormal_cell_cycle0.47592773
81MP0000470_abnormal_stomach_morphology0.47579915
82MP0003283_abnormal_digestive_organ0.47500298
83MP0001440_abnormal_grooming_behavior0.47179378
84MP0005083_abnormal_biliary_tract0.44943138
85MP0001501_abnormal_sleep_pattern0.44019460
86MP0003880_abnormal_central_pattern0.43729885
87MP0001970_abnormal_pain_threshold0.43700979
88MP0004233_abnormal_muscle_weight0.40975126
89MP0003936_abnormal_reproductive_system0.40601337
90MP0008995_early_reproductive_senescence0.40541468
91MP0009697_abnormal_copulation0.40273289
92MP0005166_decreased_susceptibility_to0.39420285
93MP0002168_other_aberrant_phenotype0.36360186
94MP0002928_abnormal_bile_duct0.36168671
95MP0000566_synostosis0.34427741
96MP0005535_abnormal_body_temperature0.32833018
97MP0000230_abnormal_systemic_arterial0.32524437
98MP0000467_abnormal_esophagus_morphology0.32019243
99MP0003635_abnormal_synaptic_transmissio0.31895199
100MP0004036_abnormal_muscle_relaxation0.30627249

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.86600263
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.08057216
3Absent/shortened dynein arms (HP:0200106)6.08057216
4Asymmetric septal hypertrophy (HP:0001670)5.62476251
5Resting tremor (HP:0002322)4.79176432
6Attenuation of retinal blood vessels (HP:0007843)4.75588174
7Bony spicule pigmentary retinopathy (HP:0007737)4.72129578
8Tubulointerstitial nephritis (HP:0001970)4.65449102
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.62750122
10Abnormal ciliary motility (HP:0012262)4.51670566
11Abnormal respiratory motile cilium physiology (HP:0012261)4.42937350
12Chronic hepatic failure (HP:0100626)4.41947723
13Hyperkalemia (HP:0002153)4.31980324
14Abnormal respiratory epithelium morphology (HP:0012253)4.26654560
15Abnormal respiratory motile cilium morphology (HP:0005938)4.26654560
16Infertility (HP:0000789)4.22156769
17Male infertility (HP:0003251)4.16329176
18Potter facies (HP:0002009)4.11794625
19Facial shape deformation (HP:0011334)4.11794625
20Nasal polyposis (HP:0100582)4.10232905
21Hypoplastic ischia (HP:0003175)4.02519869
22Bell-shaped thorax (HP:0001591)4.02180856
23Abnormality of macular pigmentation (HP:0008002)4.00680102
24Aplasia/Hypoplasia of the earlobes (HP:0009906)3.81935886
25Azoospermia (HP:0000027)3.80475442
26Enlarged epiphyses (HP:0010580)3.75160849
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.74007543
28Abnormal rod and cone electroretinograms (HP:0008323)3.71043388
29Abnormal spermatogenesis (HP:0008669)3.65456367
30Abnormality of the ischium (HP:0003174)3.56437358
31Cone-rod dystrophy (HP:0000548)3.49302949
32Impulsivity (HP:0100710)3.43872510
33Hypoplasia of the thymus (HP:0000778)3.41119664
34Unilateral renal agenesis (HP:0000122)3.38758855
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.32384736
36Abnormality of the aortic arch (HP:0012303)3.30654514
37Abnormality of the nasal mucosa (HP:0000433)3.29810759
38Congenital malformation of the right heart (HP:0011723)3.25884716
39Double outlet right ventricle (HP:0001719)3.25884716
40Amelogenesis imperfecta (HP:0000705)3.10841327
41Postural instability (HP:0002172)3.03616524
42Abnormal urine output (HP:0012590)2.82809336
43Renal dysplasia (HP:0000110)2.81349231
44Nephronophthisis (HP:0000090)2.76000375
45Progressive sensorineural hearing impairment (HP:0000408)2.69552641
46Truncal obesity (HP:0001956)2.65968054
47Progressive cerebellar ataxia (HP:0002073)2.62775009
48Abnormality of the costochondral junction (HP:0000919)2.61448300
49Abnormality of potassium homeostasis (HP:0011042)2.60934455
50Generalized aminoaciduria (HP:0002909)2.60761619
51Hypoalphalipoproteinemia (HP:0003233)2.60597550
52Ventricular tachycardia (HP:0004756)2.60271734
53Stage 5 chronic kidney disease (HP:0003774)2.58864799
54Rhinitis (HP:0012384)2.55672719
55Abnormality of the parathyroid morphology (HP:0011766)2.52150371
56Abnormality of renal excretion (HP:0011036)2.45301760
57Abnormal drinking behavior (HP:0030082)2.42450812
58Polydipsia (HP:0001959)2.42450812
59Portal hypertension (HP:0001409)2.40509708
60Insulin-resistant diabetes mellitus (HP:0000831)2.35541524
61Flattened epiphyses (HP:0003071)2.34315748
62Abnormality of the renal medulla (HP:0100957)2.33777652
63Menstrual irregularities (HP:0000858)2.32827798
64Abnormality of dental color (HP:0011073)2.30511872
65Renovascular hypertension (HP:0100817)2.27438640
66Polyuria (HP:0000103)2.27235634
67Tubulointerstitial abnormality (HP:0001969)2.23397928
68Tetany (HP:0001281)2.22341485
69Abnormality of the hepatic vasculature (HP:0006707)2.20439072
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.17598604
71Absent epiphyses (HP:0010577)2.17598604
72Abnormality of the epiphysis of the femoral head (HP:0010574)2.13558255
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12094005
74Epiphyseal dysplasia (HP:0002656)2.11774716
75Abnormality of the pubic bones (HP:0003172)2.11478786
76Hyponatremia (HP:0002902)2.08095967
77Osteomalacia (HP:0002749)2.06831574
78Hyperthyroidism (HP:0000836)2.06025006
79Renal Fanconi syndrome (HP:0001994)1.98392922
80Bronchiectasis (HP:0002110)1.98383123
81Abnormality of femoral epiphyses (HP:0006499)1.97771232
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.97771232
83Transposition of the great arteries (HP:0001669)1.96284774
84Abnormal connection of the cardiac segments (HP:0011545)1.96284774
85Abnormal ventriculo-arterial connection (HP:0011563)1.96284774
86Bradycardia (HP:0001662)1.95603400
87Hypophosphatemic rickets (HP:0004912)1.94197502
88Abnormality of the femoral head (HP:0003368)1.93895753
89Widely patent fontanelles and sutures (HP:0004492)1.88011929
90Chronic bronchitis (HP:0004469)1.87822972
91Hypoplastic left heart (HP:0004383)1.84179704
92Amblyopia (HP:0000646)1.82925139
93Increased purine levels (HP:0004368)1.81460204
94Hyperuricemia (HP:0002149)1.81460204
95Hypoparathyroidism (HP:0000829)1.81329369
96Spastic paraparesis (HP:0002313)1.80371544
97Recurrent corneal erosions (HP:0000495)1.79895680
98Intellectual disability, moderate (HP:0002342)1.78420679
99Recurrent pneumonia (HP:0006532)1.76046030
100Progressive hearing impairment (HP:0001730)1.75299295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.49214901
2TESK16.84305631
3DDR24.77259109
4INSRR3.57168190
5STK383.16198922
6PNCK3.07727334
7PLK23.06514696
8BRD42.95833530
9MAP4K22.78393490
10MAPK152.75171923
11CAMK1G2.27265222
12STK38L2.25565656
13PRKD32.16582740
14PIK3CG1.83186412
15WNK11.66119122
16PDPK11.65008555
17PDK11.52906791
18MST1R1.42536846
19CDK71.32462506
20SIK21.25020283
21CDK121.24242279
22DYRK1B1.21802389
23NEK61.16368649
24PTK2B1.12744490
25KSR21.09251864
26LATS21.07474698
27TYRO31.00533781
28MAP3K90.90115664
29MAP2K20.84863414
30AKT30.83012098
31CAMK1D0.78961600
32MAP3K110.76942827
33WNK40.76422999
34LATS10.73495125
35RPS6KA20.70481369
36UHMK10.68560078
37MAP3K20.65740404
38BRAF0.64464682
39PRKAA20.62278272
40RPS6KA10.60964485
41PRKG10.60510066
42STK390.59822514
43PRKG20.59806640
44ROCK10.52814025
45BMPR1B0.51134905
46MAP3K80.50468872
47NTRK30.50422658
48TESK20.49566333
49CAMK10.48743027
50CDK40.46488143
51SGK2230.45010582
52SGK4940.45010582
53CDK20.44621359
54GSK3B0.44213227
55MAPK10.43117573
56CDK10.41220291
57CDK30.39306607
58ARAF0.36612743
59RPS6KA60.35851424
60RPS6KL10.34530301
61RPS6KC10.34530301
62MAPK80.34530271
63MARK10.32521443
64PRKCZ0.32515832
65MUSK0.32109312
66MAP3K10.29895492
67SGK10.29795714
68MTOR0.29491796
69CAMK40.29278834
70ZAK0.29162178
71CHEK10.27892617
72MAP3K40.26745054
73TAF10.26022005
74PRKCG0.25809575
75NUAK10.24763711
76MAPK140.24306258
77PASK0.23323051
78ACVR1B0.21705049
79PRKCB0.19483295
80MAPK110.19344295
81TXK0.16792059
82RIPK40.16001392
83MAPK100.15988183
84AKT10.15659766
85TIE10.14824364
86BRSK10.14399840
87MARK20.12952642
88PKN10.12889149
89OXSR10.12333733
90MET0.12253011
91MAPK90.10728435
92VRK10.10261074
93JAK30.10260069
94TNIK0.10197903
95TLK10.09254256
96PRKACB0.09020446
97PINK10.08927796
98SGK20.08904050
99IKBKB0.08701739
100PRKCQ0.08566110

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.35294314
2Fatty acid biosynthesis_Homo sapiens_hsa000616.80702418
3Olfactory transduction_Homo sapiens_hsa047403.54695369
4Butanoate metabolism_Homo sapiens_hsa006502.46232115
5Taste transduction_Homo sapiens_hsa047421.91920417
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.90923925
7Autoimmune thyroid disease_Homo sapiens_hsa053201.84738396
8Allograft rejection_Homo sapiens_hsa053301.82671500
9Type I diabetes mellitus_Homo sapiens_hsa049401.82018562
10Fatty acid degradation_Homo sapiens_hsa000711.80742187
11Dorso-ventral axis formation_Homo sapiens_hsa043201.76780838
12Graft-versus-host disease_Homo sapiens_hsa053321.67626206
13Fatty acid metabolism_Homo sapiens_hsa012121.65821133
14Type II diabetes mellitus_Homo sapiens_hsa049301.63746851
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63666149
16Phenylalanine metabolism_Homo sapiens_hsa003601.55776091
17Antigen processing and presentation_Homo sapiens_hsa046121.55273916
18RNA transport_Homo sapiens_hsa030131.48352969
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48246260
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40666956
21Selenocompound metabolism_Homo sapiens_hsa004501.33150256
22Viral myocarditis_Homo sapiens_hsa054161.32645187
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28445716
24Arginine and proline metabolism_Homo sapiens_hsa003301.20989320
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.19536765
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18098206
27Endocytosis_Homo sapiens_hsa041441.17122938
28Phototransduction_Homo sapiens_hsa047441.15322560
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13886471
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04771996
31Inositol phosphate metabolism_Homo sapiens_hsa005621.04365929
32Protein digestion and absorption_Homo sapiens_hsa049741.00305986
33PPAR signaling pathway_Homo sapiens_hsa033200.97037512
34Primary bile acid biosynthesis_Homo sapiens_hsa001200.96853048
35Salivary secretion_Homo sapiens_hsa049700.92248026
36Calcium signaling pathway_Homo sapiens_hsa040200.92126427
37Morphine addiction_Homo sapiens_hsa050320.89521290
38cAMP signaling pathway_Homo sapiens_hsa040240.88369528
39Cardiac muscle contraction_Homo sapiens_hsa042600.84753164
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83636453
41Nicotine addiction_Homo sapiens_hsa050330.83043573
42Circadian entrainment_Homo sapiens_hsa047130.81583077
43Oocyte meiosis_Homo sapiens_hsa041140.80816994
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78222522
45Arginine biosynthesis_Homo sapiens_hsa002200.74836237
46Synaptic vesicle cycle_Homo sapiens_hsa047210.73561948
47Influenza A_Homo sapiens_hsa051640.72831021
48Hedgehog signaling pathway_Homo sapiens_hsa043400.72310058
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71429741
50Tyrosine metabolism_Homo sapiens_hsa003500.70955573
51Fat digestion and absorption_Homo sapiens_hsa049750.70378528
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69752710
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69390407
54ABC transporters_Homo sapiens_hsa020100.68933240
55Gastric acid secretion_Homo sapiens_hsa049710.67815457
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66138556
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.65712683
58Renin-angiotensin system_Homo sapiens_hsa046140.64743060
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60595689
60Estrogen signaling pathway_Homo sapiens_hsa049150.56735012
61MAPK signaling pathway_Homo sapiens_hsa040100.55016194
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51198700
63Renin secretion_Homo sapiens_hsa049240.51158919
64Glutamatergic synapse_Homo sapiens_hsa047240.50331061
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49303699
66Insulin secretion_Homo sapiens_hsa049110.49157422
67Glycerolipid metabolism_Homo sapiens_hsa005610.48538229
68Purine metabolism_Homo sapiens_hsa002300.48210889
69VEGF signaling pathway_Homo sapiens_hsa043700.46209489
70Retinol metabolism_Homo sapiens_hsa008300.44965523
71Acute myeloid leukemia_Homo sapiens_hsa052210.44176924
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44115470
73Basal transcription factors_Homo sapiens_hsa030220.42984260
74Viral carcinogenesis_Homo sapiens_hsa052030.42514536
75Bile secretion_Homo sapiens_hsa049760.42171705
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.39634190
77Tight junction_Homo sapiens_hsa045300.39034308
78mRNA surveillance pathway_Homo sapiens_hsa030150.37282319
79Vitamin B6 metabolism_Homo sapiens_hsa007500.35168218
80Pancreatic secretion_Homo sapiens_hsa049720.34105684
81Cholinergic synapse_Homo sapiens_hsa047250.32922400
82Serotonergic synapse_Homo sapiens_hsa047260.32590137
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.30218799
84Herpes simplex infection_Homo sapiens_hsa051680.26903126
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24977707
86Oxytocin signaling pathway_Homo sapiens_hsa049210.23827373
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23163282
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22594531
89GABAergic synapse_Homo sapiens_hsa047270.21657618
90Long-term potentiation_Homo sapiens_hsa047200.21445293
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21442974
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21419362
93Huntingtons disease_Homo sapiens_hsa050160.20656562
94Adherens junction_Homo sapiens_hsa045200.18066093
95Nitrogen metabolism_Homo sapiens_hsa009100.16474991
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16329659
97Epstein-Barr virus infection_Homo sapiens_hsa051690.15625038
98Prolactin signaling pathway_Homo sapiens_hsa049170.15244266
99Fanconi anemia pathway_Homo sapiens_hsa034600.14886702
100Linoleic acid metabolism_Homo sapiens_hsa005910.14401826

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