PPP1R27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)9.64517848
2plasma membrane repair (GO:0001778)8.84893788
3skeletal muscle fiber development (GO:0048741)8.53432943
4actin filament-based movement (GO:0030048)8.20948344
5skeletal muscle tissue regeneration (GO:0043403)7.48819797
6myotube cell development (GO:0014904)7.19458199
7striated muscle contraction (GO:0006941)6.71667017
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.68979121
9sarcomere organization (GO:0045214)6.40610809
10creatine metabolic process (GO:0006600)6.40285651
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.36983846
12pyrimidine ribonucleoside catabolic process (GO:0046133)6.13804860
13glycogen catabolic process (GO:0005980)5.90804810
14striated muscle atrophy (GO:0014891)5.87590803
15cytidine metabolic process (GO:0046087)5.85712110
16cytidine catabolic process (GO:0006216)5.85712110
17cytidine deamination (GO:0009972)5.85712110
18muscle contraction (GO:0006936)5.84205583
19carnitine shuttle (GO:0006853)5.75496444
20response to inactivity (GO:0014854)5.72627573
21myofibril assembly (GO:0030239)5.61984928
22glucan catabolic process (GO:0009251)5.52618274
23response to muscle activity (GO:0014850)5.51228424
24purine nucleotide salvage (GO:0032261)5.49048738
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.31474702
26glucan biosynthetic process (GO:0009250)5.25638697
27glycogen biosynthetic process (GO:0005978)5.25638697
28regulation of cell communication by electrical coupling (GO:0010649)5.21318577
29muscle system process (GO:0003012)5.15185124
30muscle atrophy (GO:0014889)5.15023957
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.12133734
32cellular polysaccharide catabolic process (GO:0044247)5.11064688
33muscle fiber development (GO:0048747)5.03682012
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.01106751
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.00113657
36striated muscle adaptation (GO:0014888)4.94861853
37fatty acid transmembrane transport (GO:1902001)4.86887172
38polysaccharide catabolic process (GO:0000272)4.83186721
39cardiac myofibril assembly (GO:0055003)4.81569111
40carnitine transmembrane transport (GO:1902603)4.71725981
41IMP metabolic process (GO:0046040)4.66467850
42ubiquinone biosynthetic process (GO:0006744)4.59672842
43regulation of acyl-CoA biosynthetic process (GO:0050812)4.55762138
44actomyosin structure organization (GO:0031032)4.55295781
45positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.44589706
46regulation of actin filament-based movement (GO:1903115)4.40161331
47glycogen metabolic process (GO:0005977)4.39874569
48amino-acid betaine transport (GO:0015838)4.35592223
49carnitine transport (GO:0015879)4.35592223
50glucan metabolic process (GO:0044042)4.30977411
51cellular glucan metabolic process (GO:0006073)4.30977411
52cardiac muscle hypertrophy (GO:0003300)4.29497888
53regulation of cofactor metabolic process (GO:0051193)4.10005876
54regulation of coenzyme metabolic process (GO:0051196)4.10005876
55striated muscle hypertrophy (GO:0014897)4.08851804
56ubiquinone metabolic process (GO:0006743)4.04799570
57NADH metabolic process (GO:0006734)4.04794215
58response to activity (GO:0014823)4.02229739
59muscle cell fate commitment (GO:0042693)4.01781031
60muscle adaptation (GO:0043500)4.01178814
61skeletal muscle tissue development (GO:0007519)4.00496931
62muscle organ development (GO:0007517)3.96203354
63regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.95908914
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.95221977
65negative regulation of potassium ion transmembrane transport (GO:1901380)3.93424102
66adult heart development (GO:0007512)3.92130478
67tricarboxylic acid cycle (GO:0006099)3.91837125
68muscle structure development (GO:0061061)3.91266232
692-oxoglutarate metabolic process (GO:0006103)3.89479088
70muscle organ morphogenesis (GO:0048644)3.86673812
71myotube differentiation (GO:0014902)3.83151561
72negative regulation of skeletal muscle tissue development (GO:0048642)3.82903953
73regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.81611021
74regulation of skeletal muscle cell differentiation (GO:2001014)3.80431358
75striated muscle cell development (GO:0055002)3.79295204
76regulation of myoblast differentiation (GO:0045661)3.77828233
77muscle cell cellular homeostasis (GO:0046716)3.74539202
78muscle hypertrophy (GO:0014896)3.73551173
79fructose metabolic process (GO:0006000)3.67849170
80quinone biosynthetic process (GO:1901663)3.67189917
81negative regulation of muscle hypertrophy (GO:0014741)3.65999052
82muscle tissue morphogenesis (GO:0060415)3.63480291
83skeletal muscle cell differentiation (GO:0035914)3.57727544
84AMP metabolic process (GO:0046033)3.56969451
85IMP biosynthetic process (GO:0006188)3.56070983
86cardiac muscle contraction (GO:0060048)3.55183515
87neuromuscular synaptic transmission (GO:0007274)3.53229677
88cellular carbohydrate catabolic process (GO:0044275)3.50824501
89neuronal action potential propagation (GO:0019227)3.49221619
90regulation of relaxation of muscle (GO:1901077)3.48312912
91cellular response to dexamethasone stimulus (GO:0071549)3.42353074
92positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.39007100
93regulation of sulfur metabolic process (GO:0042762)3.37608043
94negative regulation of cAMP-mediated signaling (GO:0043951)3.37426912
95gluconeogenesis (GO:0006094)3.34096049
96positive regulation of myotube differentiation (GO:0010831)3.29586420
97cardiac muscle adaptation (GO:0014887)3.28423396
98cardiac muscle hypertrophy in response to stress (GO:0014898)3.28423396
99muscle hypertrophy in response to stress (GO:0003299)3.28423396
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25136898
101cardiac muscle tissue morphogenesis (GO:0055008)3.24976131
102heart process (GO:0003015)3.23484178
103heart contraction (GO:0060047)3.23484178
104muscle cell development (GO:0055001)3.22551260
105regulation of calcium ion transmembrane transport (GO:1903169)3.21373062
106regulation of calcium ion transmembrane transporter activity (GO:1901019)3.21373062
107negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.21179869
108negative regulation of calcium ion transmembrane transport (GO:1903170)3.21179869
109myoblast fusion (GO:0007520)3.21095277
110response to dexamethasone (GO:0071548)3.19109686
111positive regulation of cation channel activity (GO:2001259)3.19048758
112striated muscle tissue development (GO:0014706)3.17771345
113oxidative phosphorylation (GO:0006119)3.16567827
114neuromuscular junction development (GO:0007528)3.11977755
115positive regulation of myoblast differentiation (GO:0045663)3.08935614
116regulation of sequestering of triglyceride (GO:0010889)3.08928611
117quaternary ammonium group transport (GO:0015697)3.06180054
118cellular polysaccharide biosynthetic process (GO:0033692)3.05648661
119negative regulation of muscle contraction (GO:0045932)3.04277617
120cellular polysaccharide metabolic process (GO:0044264)3.03363669
121regulation of striated muscle contraction (GO:0006942)3.02750964
122muscle filament sliding (GO:0030049)13.5036998
123actin-myosin filament sliding (GO:0033275)13.5036998
124regulation of skeletal muscle contraction (GO:0014819)11.7752486
125skeletal muscle contraction (GO:0003009)11.7221421
126actin-mediated cell contraction (GO:0070252)11.0430600
127sarcoplasmic reticulum calcium ion transport (GO:0070296)10.7188300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.54958226
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.30789061
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94274704
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.40366503
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.19347604
6VDR_21846776_ChIP-Seq_THP-1_Human2.87817099
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79898855
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.78270598
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.73384668
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.72346728
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.72346728
12BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.43668675
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41483150
14ZNF274_21170338_ChIP-Seq_K562_Hela2.20885525
15ZNF263_19887448_ChIP-Seq_K562_Human2.18128614
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10463752
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.10026950
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08739650
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92035687
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88009694
21CTCF_21964334_ChIP-Seq_BJAB-B_Human1.87448073
22IGF1R_20145208_ChIP-Seq_DFB_Human1.85210271
23EZH2_22144423_ChIP-Seq_EOC_Human1.83041614
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.77068341
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71769699
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.67323323
27VDR_22108803_ChIP-Seq_LS180_Human1.67043662
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63849684
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63167263
30CBP_20019798_ChIP-Seq_JUKART_Human1.63167263
31CTCF_27219007_Chip-Seq_Bcells_Human1.59938352
32VDR_24763502_ChIP-Seq_THP-1_Human1.59086626
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55999614
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.53771723
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.51860195
36FOXH1_21741376_ChIP-Seq_ESCs_Human1.49844016
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48673467
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48441793
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45682197
40CTCF_21964334_Chip-Seq_Bcells_Human1.44695871
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43956419
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43806948
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.43653268
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.42669132
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41948435
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41181123
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.40191337
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36537115
49SA1_27219007_Chip-Seq_Bcells_Human1.35035003
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34691848
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34606779
52AR_21572438_ChIP-Seq_LNCaP_Human1.34175349
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.32826437
54OCT4_20526341_ChIP-Seq_ESCs_Human1.31472046
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.31406869
56GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.31218730
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.30374033
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29585531
59ER_23166858_ChIP-Seq_MCF-7_Human1.27146108
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25591564
61STAT1_20625510_ChIP-Seq_HELA_Human1.24712521
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22949421
63LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22944166
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21945995
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19998194
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19540794
67CTCF_26484167_Chip-Seq_Bcells_Mouse1.17129313
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16300608
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14926277
70NANOG_20526341_ChIP-Seq_ESCs_Human1.13007063
71RAC3_21632823_ChIP-Seq_H3396_Human1.12629024
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12114666
73VDR_24787735_ChIP-Seq_THP-1_Human1.11354745
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11251128
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10936250
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.10642148
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10134290
78MYC_27129775_Chip-Seq_CORNEA_Mouse1.07810416
79SPI1_20517297_ChIP-Seq_HL60_Human1.06413520
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05904994
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05224773
82CBP_21632823_ChIP-Seq_H3396_Human1.02572514
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.01758608
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00534853
85GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98871484
86NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98486101
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98377246
88DROSHA_22980978_ChIP-Seq_HELA_Human0.97920452
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.97588875
90P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97566307
91P68_20966046_ChIP-Seq_HELA_Human0.97422551
92GATA3_21867929_ChIP-Seq_TH1_Mouse0.97335369
93LXR_22158963_ChIP-Seq_LIVER_Mouse0.96993034
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96530402
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95192547
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95076198
97TP63_22573176_ChIP-Seq_HFKS_Human0.94332264
98RACK7_27058665_Chip-Seq_MCF-7_Human0.93474846
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93466599
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.93271461
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92808030
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92032637
103E2F1_20622854_ChIP-Seq_HELA_Human0.90863720
104TCF7_22412390_ChIP-Seq_EML_Mouse0.90434456
105CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90166327
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89986309
107CEBPB_22108803_ChIP-Seq_LS180_Human0.89886909
108CLOCK_20551151_ChIP-Seq_293T_Human0.89649117
109OCT1_27270436_Chip-Seq_PROSTATE_Human0.89598846
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88967698
111GATA3_21867929_ChIP-Seq_CD8_Mouse0.88167618
112CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88083357
113KDM2B_26808549_Chip-Seq_DND41_Human0.88012521
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87401345
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86554193
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85259038
117RXR_22158963_ChIP-Seq_LIVER_Mouse0.85173162
118BCL6_27268052_Chip-Seq_Bcells_Human0.84646357
119CREB1_26743006_Chip-Seq_LNCaP_Human0.84645714
120WDR5_24793694_ChIP-Seq_LNCAP_Human0.83867980
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83762947
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83486424
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83058865
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82932922
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82878344
126P53_21459846_ChIP-Seq_SAOS-2_Human0.82246775
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81544525
128NCOR_22424771_ChIP-Seq_293T_Human0.81415784
129CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81227351
130LXR_22292898_ChIP-Seq_THP-1_Human0.81179419
131RARB_27405468_Chip-Seq_BRAIN_Mouse0.80993389
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.80606783
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79535898
134CIITA_25753668_ChIP-Seq_RAJI_Human0.77612640
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77445037
136MYC_19829295_ChIP-Seq_ESCs_Human0.76889464
137P300_27268052_Chip-Seq_Bcells_Human0.76570921
138OCT4_19829295_ChIP-Seq_ESCs_Human0.76320131
139TAF2_19829295_ChIP-Seq_ESCs_Human0.75373440
140PHF8_20622853_ChIP-Seq_HELA_Human0.74578626
141SOX2_19829295_ChIP-Seq_ESCs_Human0.72871684
142NANOG_19829295_ChIP-Seq_ESCs_Human0.72871684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.90977525
2MP0003646_muscle_fatigue6.38288652
3MP0000749_muscle_degeneration6.29107369
4MP0000751_myopathy5.59519235
5MP0000747_muscle_weakness4.63659929
6MP0002106_abnormal_muscle_physiology4.22432744
7MP0004036_abnormal_muscle_relaxation3.87074341
8MP0000759_abnormal_skeletal_muscle3.83710954
9MP0005451_abnormal_body_composition3.80276213
10MP0005369_muscle_phenotype3.58493653
11MP0002269_muscular_atrophy3.52519955
12MP0004087_abnormal_muscle_fiber3.51568984
13MP0002837_dystrophic_cardiac_calcinosis3.44055470
14MP0004130_abnormal_muscle_cell3.31614174
15MP0000750_abnormal_muscle_regeneration3.23506211
16MP0005620_abnormal_muscle_contractility3.01865116
17MP0004233_abnormal_muscle_weight2.82520951
18MP0000733_abnormal_muscle_development2.76984305
19MP0002108_abnormal_muscle_morphology2.27624762
20MP0000013_abnormal_adipose_tissue2.20389202
21MP0002332_abnormal_exercise_endurance2.07215673
22MP0005330_cardiomyopathy1.98976052
23MP0006036_abnormal_mitochondrial_physio1.98791171
24MP0004270_analgesia1.65743426
25MP0004084_abnormal_cardiac_muscle1.63166147
26MP0002971_abnormal_brown_adipose1.57944463
27MP0004185_abnormal_adipocyte_glucose1.53235800
28MP0004215_abnormal_myocardial_fiber1.42232589
29MP0005666_abnormal_adipose_tissue1.42000477
30MP0004484_altered_response_of1.36339155
31MP0002972_abnormal_cardiac_muscle1.32934189
32MP0005375_adipose_tissue_phenotype1.32230112
33MP0010630_abnormal_cardiac_muscle1.22161956
34MP0003221_abnormal_cardiomyocyte_apopto1.18976310
35MP0000003_abnormal_adipose_tissue1.16239334
36MP0002822_catalepsy1.16073087
37MP0001661_extended_life_span1.07019968
38MP0003806_abnormal_nucleotide_metabolis1.07002875
39MP0005266_abnormal_metabolism1.04337805
40MP0003950_abnormal_plasma_membrane1.02969399
41MP0006035_abnormal_mitochondrial_morpho1.00315670
42MP0004134_abnormal_chest_morphology0.94844517
43MP0002234_abnormal_pharynx_morphology0.92126446
44MP0005385_cardiovascular_system_phenoty0.86703517
45MP0001544_abnormal_cardiovascular_syste0.86703517
46MP0002876_abnormal_thyroid_physiology0.84064114
47MP0003705_abnormal_hypodermis_morpholog0.81264698
48MP0004043_abnormal_pH_regulation0.76235430
49MP0005410_abnormal_fertilization0.74611205
50MP0003137_abnormal_impulse_conducting0.74234913
51MP0003656_abnormal_erythrocyte_physiolo0.72553846
52MP0004147_increased_porphyrin_level0.71190052
53MP0009250_abnormal_appendicular_skeleto0.67561643
54MP0001299_abnormal_eye_distance/0.66881093
55MP0000762_abnormal_tongue_morphology0.65656739
56MP0005670_abnormal_white_adipose0.63035836
57MP0002078_abnormal_glucose_homeostasis0.62903921
58MP0000372_irregular_coat_pigmentation0.62067219
59MP0005332_abnormal_amino_acid0.57403119
60MP0005334_abnormal_fat_pad0.55687967
61MP0008961_abnormal_basal_metabolism0.54946564
62MP0002638_abnormal_pupillary_reflex0.53081253
63MP0005584_abnormal_enzyme/coenzyme_acti0.52277614
64MP0005167_abnormal_blood-brain_barrier0.51454330
65MP0000266_abnormal_heart_morphology0.51121301
66MP0000343_altered_response_to0.48802801
67MP0003959_abnormal_lean_body0.48637543
68MP0009780_abnormal_chondrocyte_physiolo0.48216916
69MP0005452_abnormal_adipose_tissue0.47913060
70MP0005645_abnormal_hypothalamus_physiol0.45473085
71MP0008569_lethality_at_weaning0.41928665
72MP0003045_fibrosis0.41769140
73MP0009672_abnormal_birth_weight0.41509806
74MP0002127_abnormal_cardiovascular_syste0.41508555
75MP0001986_abnormal_taste_sensitivity0.40977371
76MP0008775_abnormal_heart_ventricle0.40295361
77MP0006138_congestive_heart_failure0.39775097
78MP0003879_abnormal_hair_cell0.39380612
79MP0002896_abnormal_bone_mineralization0.38720068
80MP0005275_abnormal_skin_tensile0.37471533
81MP0002114_abnormal_axial_skeleton0.37466340
82MP0005319_abnormal_enzyme/_coenzyme0.34588280
83MP0001849_ear_inflammation0.34570542
84MP0004381_abnormal_hair_follicle0.32600694
85MP0005083_abnormal_biliary_tract0.32147002
86MP0003948_abnormal_gas_homeostasis0.31286471
87MP0005423_abnormal_somatic_nervous0.31229212
88MP0002067_abnormal_sensory_capabilities0.30899243
89MP0000569_abnormal_digit_pigmentation0.30850217
90MP0002734_abnormal_mechanical_nocicepti0.30402999
91MP0008872_abnormal_physiological_respon0.29193865
92MP0005166_decreased_susceptibility_to0.28012679
93MP0000579_abnormal_nail_morphology0.27925214
94MP0009115_abnormal_fat_cell0.27735643
95MP0002009_preneoplasia0.27203373
96MP0005535_abnormal_body_temperature0.27019216
97MP0002089_abnormal_postnatal_growth/wei0.26992108
98MP0002118_abnormal_lipid_homeostasis0.25096336
99MP0001440_abnormal_grooming_behavior0.25021414
100MP0002066_abnormal_motor_capabilities/c0.24973133
101MP0000230_abnormal_systemic_arterial0.24843366
102MP0005376_homeostasis/metabolism_phenot0.24475859
103MP0004142_abnormal_muscle_tone0.23922442
104MP0004924_abnormal_behavior0.23817945
105MP0005386_behavior/neurological_phenoty0.23817945
106MP0004085_abnormal_heartbeat0.23576887
107MP0000383_abnormal_hair_follicle0.23077500
108MP0004510_myositis0.22024511
109MP0001485_abnormal_pinna_reflex0.22010339
110MP0001943_abnormal_respiration0.22007007
111MP0005503_abnormal_tendon_morphology0.21733545
112MP0006276_abnormal_autonomic_nervous0.20130776
113MP0009379_abnormal_foot_pigmentation0.19900619
114MP0003828_pulmonary_edema0.19797066
115MP0001765_abnormal_ion_homeostasis0.19748131
116MP0004197_abnormal_fetal_growth/weight/0.19558574
117MP0005187_abnormal_penis_morphology0.19169342
118MP0000427_abnormal_hair_cycle0.18889325
119MP0001502_abnormal_circadian_rhythm0.18835023
120MP0003195_calcinosis0.18668025
121MP0001346_abnormal_lacrimal_gland0.17984794
122MP0002970_abnormal_white_adipose0.16971460
123MP0001243_abnormal_dermal_layer0.16923430
124MP0002877_abnormal_melanocyte_morpholog0.16807457
125MP0001853_heart_inflammation0.16174136
126MP0002128_abnormal_blood_circulation0.16099567

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)8.43729381
2Exercise-induced myalgia (HP:0003738)8.04778031
3Distal arthrogryposis (HP:0005684)7.23672494
4Exercise-induced muscle cramps (HP:0003710)7.04578007
5Myopathic facies (HP:0002058)6.78457449
6Muscle hypertrophy of the lower extremities (HP:0008968)6.01700939
7Ulnar deviation of the wrist (HP:0003049)5.94885906
8Round ear (HP:0100830)5.93629318
9Calf muscle hypertrophy (HP:0008981)5.41002186
10Muscle fiber splitting (HP:0003555)5.22982167
11Hyporeflexia of lower limbs (HP:0002600)5.16604423
12Calcaneovalgus deformity (HP:0001848)5.13907286
13Difficulty running (HP:0009046)5.05383738
14Deformed tarsal bones (HP:0008119)4.88845329
15Myoglobinuria (HP:0002913)4.78884653
16Absent phalangeal crease (HP:0006109)4.67440411
17EMG: myopathic abnormalities (HP:0003458)4.50520405
18Muscle stiffness (HP:0003552)4.47698503
19Rhabdomyolysis (HP:0003201)4.01968396
20Abnormal finger flexion creases (HP:0006143)3.97761644
21Abnormality of skeletal muscle fiber size (HP:0012084)3.91891964
22Increased connective tissue (HP:0009025)3.88378317
23Abnormality of the calf musculature (HP:0001430)3.78003502
24Neck muscle weakness (HP:0000467)3.77032245
25Myotonia (HP:0002486)3.66078807
26Rimmed vacuoles (HP:0003805)3.58264139
27Malignant hyperthermia (HP:0002047)3.49241026
28Frequent falls (HP:0002359)3.42771279
29Increased variability in muscle fiber diameter (HP:0003557)3.38013486
30Areflexia of lower limbs (HP:0002522)3.35722658
31Difficulty climbing stairs (HP:0003551)3.14044826
32Abnormality of the left ventricular outflow tract (HP:0011103)3.09507306
33Subaortic stenosis (HP:0001682)3.09507306
34Abnormality of the calcaneus (HP:0008364)3.06041431
35Pelvic girdle muscle weakness (HP:0003749)3.02720604
36Shoulder girdle muscle weakness (HP:0003547)3.01706727
37Abnormality of the musculature of the pelvis (HP:0001469)2.93437511
38Abnormality of the hip-girdle musculature (HP:0001445)2.93437511
39Fatigable weakness (HP:0003473)2.83570652
40Abnormality of the neuromuscular junction (HP:0003398)2.83570652
41Hyperkalemia (HP:0002153)2.76527193
42Asymmetric septal hypertrophy (HP:0001670)2.74319331
43Progressive muscle weakness (HP:0003323)2.72693229
44Bundle branch block (HP:0011710)2.67396568
45Slender build (HP:0001533)2.64935464
46EMG: neuropathic changes (HP:0003445)2.64297686
47Distal lower limb muscle weakness (HP:0009053)2.57573203
48Bulbar palsy (HP:0001283)2.54293650
49Generalized muscle weakness (HP:0003324)2.47252028
50Weak cry (HP:0001612)2.44328832
51Mildly elevated creatine phosphokinase (HP:0008180)2.41125920
52Facial diplegia (HP:0001349)2.38209273
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.35264722
54Gowers sign (HP:0003391)2.33792530
55Proximal amyotrophy (HP:0007126)2.31174641
56Spinal rigidity (HP:0003306)2.30419678
57Paralysis (HP:0003470)2.29952694
58Fetal akinesia sequence (HP:0001989)2.29332967
59Muscular dystrophy (HP:0003560)2.26109055
60Sudden death (HP:0001699)2.22708187
61Scapular winging (HP:0003691)2.22339015
62Nonprogressive disorder (HP:0003680)2.20247109
63Ulnar deviation of finger (HP:0009465)2.13788265
64Limb-girdle muscle weakness (HP:0003325)2.12858192
65Abnormality of the shoulder girdle musculature (HP:0001435)2.11003467
66Hip contracture (HP:0003273)2.07733198
67Exercise intolerance (HP:0003546)2.05735026
68Muscle fiber inclusion bodies (HP:0100299)11.6621246
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)10.8986035
70Nemaline bodies (HP:0003798)10.5143199
71Limb-girdle muscle atrophy (HP:0003797)1.99281753
72Waddling gait (HP:0002515)1.94099296
73Metatarsus adductus (HP:0001840)1.89019426
74Increased intramyocellular lipid droplets (HP:0012240)1.88448934
75Distal lower limb amyotrophy (HP:0008944)1.87026721
76Hypoplastic ischia (HP:0003175)1.86950979
77Achilles tendon contracture (HP:0001771)1.81483635
78Long clavicles (HP:0000890)1.80997463
79Increased muscle lipid content (HP:0009058)1.77636465
80Heart block (HP:0012722)1.71817970
81Respiratory insufficiency due to muscle weakness (HP:0002747)1.71419829
82Type 2 muscle fiber atrophy (HP:0003554)1.70404862
83Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.69710880
84Abnormality of the Achilles tendon (HP:0005109)1.65059395
85Ragged-red muscle fibers (HP:0003200)1.63141318
86Abnormality of the ischium (HP:0003174)1.61634341
87Tarsal synostosis (HP:0008368)1.61591362
88Popliteal pterygium (HP:0009756)1.59406905
89Ventricular tachycardia (HP:0004756)1.59076233
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58759093
91Abnormal atrioventricular conduction (HP:0005150)1.55528084
92Easy fatigability (HP:0003388)1.53135461
93Muscle fiber atrophy (HP:0100295)1.52526702
94Adducted thumb (HP:0001181)1.51587430
95Dilated cardiomyopathy (HP:0001644)1.47107688
96Synostosis involving bones of the lower limbs (HP:0009138)1.44703929
97Synostosis involving bones of the feet (HP:0009140)1.44703929
98Congenital hip dislocation (HP:0001374)1.42890436
99Lower limb amyotrophy (HP:0007210)1.42750477
100Amniotic constriction ring (HP:0009775)1.41164059
101Abnormality of placental membranes (HP:0011409)1.41164059
102Abnormality of potassium homeostasis (HP:0011042)1.40543165
103Short palpebral fissure (HP:0012745)1.39498238
104Stridor (HP:0010307)1.39216302
105Limited hip movement (HP:0008800)1.38750366
106Ventricular arrhythmia (HP:0004308)1.37759105
107Lipoatrophy (HP:0100578)1.37029919
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.36931176
109Cholelithiasis (HP:0001081)1.36715970
110Increased purine levels (HP:0004368)1.36612482
111Hyperuricemia (HP:0002149)1.36612482
112Foot dorsiflexor weakness (HP:0009027)1.36597495
113Acute necrotizing encephalopathy (HP:0006965)1.34137382
114Oligomenorrhea (HP:0000876)1.33040737
115Abnormality of fatty-acid metabolism (HP:0004359)1.32394846
116Abnormality of the foot musculature (HP:0001436)1.31545281
117Abnormal mitochondria in muscle tissue (HP:0008316)1.28669860
118Insulin-resistant diabetes mellitus (HP:0000831)1.20803719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.29925272
2PHKG14.54945418
3PHKG24.54945418
4PIK3CG4.02349649
5NME13.94851362
6PDK42.81864508
7PDK32.81864508
8MAP2K32.56951515
9NEK12.04991752
10MAP3K72.04040051
11MUSK2.02440027
12PINK12.00293984
13OBSCN10.5117651
14TRIB31.98594746
15PDK21.78523443
16DMPK1.75496281
17MAPK121.44336831
18BCKDK1.41826071
19MAP2K41.38233605
20PIK3CA1.28454968
21MAP2K61.24634674
22MAP3K131.12007221
23KIT1.01873581
24MAP3K30.93823226
25AKT20.79751980
26MAPK130.75574534
27PRKAA10.73041561
28NEK90.71920455
29MAPKAPK30.71399558
30PKN20.69813896
31MAPK150.69395939
32EPHB10.68171397
33PRKAA20.65037326
34RPS6KB20.64970539
35CAMK2G0.64665848
36CAMK40.64006399
37LIMK10.62873355
38ERBB30.59431987
39MARK10.56914486
40ZAK0.55695733
41MAPK110.52976343
42TAOK20.50596039
43TBK10.49880175
44CAMK10.49557543
45TAOK30.47444596
46TRPM70.46518202
47ILK0.45098485
48MAP3K110.44939387
49RIPK10.43381158
50TAOK10.41649017
51STK240.39707557
52PTK60.39459635
53MARK30.38300638
54CAMK2A0.36729479
55PNCK0.35702508
56FRK0.34634575
57TNK20.34444229
58PRKD30.33656612
59TLK10.33192867
60STK160.32539680
61ICK0.32410094
62RPS6KB10.31473313
63PKN10.31022309
64CDK190.29786413
65MOS0.29361905
66TEC0.26584646
67MAP3K100.26114417
68MAP3K60.25652916
69PRKG10.24963864
70RPS6KA60.24927350
71DAPK20.24827204
72RIPK40.24458680
73SYK0.24438906
74MAP2K10.23923464
75PRKCQ0.23706834
76CCNB10.23639955
77GRK10.23617515
78PDPK10.22804531
79EEF2K0.22691255
80PDK10.22685138
81SGK10.21895315
82PTK2B0.21542061
83PRKACB0.20555477
84FLT30.20413099
85MAPK40.20401086
86ZAP700.19964487
87MAP3K50.19163563
88SIK10.19060120
89DYRK1B0.18312533
90RPS6KA30.18208811
91RPS6KL10.17877291
92RPS6KC10.17877291
93TYK20.17344307
94CSF1R0.17204128
95MAPKAPK50.17176597
96ROCK10.17136229
97MAP3K10.16748580
98MAP4K20.15951623
99ADRBK20.15827909
100KSR20.15269801
101CAMK2D0.14159623
102ERN10.12105008
103PRKACA0.11923698
104LATS10.10781752
105MAPK70.10723215
106BMPR1B0.10687210
107MAPK30.09218310
108TXK0.07344771
109PAK60.07038182
110IKBKB0.06822810
111PRKD10.06663259
112MAP2K20.06493145
113LRRK20.06154864
114CDK40.05884325
115TIE10.05783415
116DYRK30.05514484
117GSK3A0.05484098
118MAPK100.04625765
119NME20.03549306
120STK380.03222602
121MTOR0.02917330
122TGFBR20.02759527
123INSRR0.02449275
124JAK2-3.7008208
125MAPKAPK2-0.0514711
126ROCK2-0.0484417
127FGFR4-0.0475540
128PRKDC-0.0467344
129STK39-0.0463978
130CAMK2B-0.0414001
131RET-0.0390241
132WNK1-0.0371102
133PRKACG-0.0200394
134TESK1-0.0157933
135LATS2-0.0138628
136STK11-0.0119328
137CSNK1D-0.0098429
138RPS6KA1-0.0030726
139MAPK8-0.0030424

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.59605720
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.21882483
3Cardiac muscle contraction_Homo sapiens_hsa042603.89571038
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.54886943
5Dilated cardiomyopathy_Homo sapiens_hsa054143.39682523
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.19767638
7Starch and sucrose metabolism_Homo sapiens_hsa005003.00718527
8Propanoate metabolism_Homo sapiens_hsa006402.75986573
9Glucagon signaling pathway_Homo sapiens_hsa049222.50294780
10Carbon metabolism_Homo sapiens_hsa012002.32723120
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.30499391
12Insulin signaling pathway_Homo sapiens_hsa049102.26330640
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17961973
14Insulin resistance_Homo sapiens_hsa049312.10842305
15Oxytocin signaling pathway_Homo sapiens_hsa049212.07744940
16Circadian rhythm_Homo sapiens_hsa047102.05139568
17Pyruvate metabolism_Homo sapiens_hsa006201.91156045
18Parkinsons disease_Homo sapiens_hsa050121.88119384
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75395985
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.74846899
21Alzheimers disease_Homo sapiens_hsa050101.67585473
22Fatty acid degradation_Homo sapiens_hsa000711.64855762
23AMPK signaling pathway_Homo sapiens_hsa041521.64319961
24Galactose metabolism_Homo sapiens_hsa000521.61158808
25Oxidative phosphorylation_Homo sapiens_hsa001901.60110669
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57944018
27Calcium signaling pathway_Homo sapiens_hsa040201.53784861
28Biosynthesis of amino acids_Homo sapiens_hsa012301.52837683
29Fructose and mannose metabolism_Homo sapiens_hsa000511.40153757
30Tight junction_Homo sapiens_hsa045301.39389174
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38981480
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.37437956
33Viral myocarditis_Homo sapiens_hsa054161.30574311
34Arginine and proline metabolism_Homo sapiens_hsa003301.27976524
35Pentose phosphate pathway_Homo sapiens_hsa000301.23494379
36Fatty acid metabolism_Homo sapiens_hsa012121.14385350
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12761634
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08535050
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06709821
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.98774328
41Huntingtons disease_Homo sapiens_hsa050160.96934430
42Regulation of autophagy_Homo sapiens_hsa041400.92733814
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.88177376
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87359929
45FoxO signaling pathway_Homo sapiens_hsa040680.86219081
46Focal adhesion_Homo sapiens_hsa045100.83151955
47Phototransduction_Homo sapiens_hsa047440.81316443
48Arginine biosynthesis_Homo sapiens_hsa002200.78018613
49Fatty acid biosynthesis_Homo sapiens_hsa000610.77586324
50VEGF signaling pathway_Homo sapiens_hsa043700.75036672
51HIF-1 signaling pathway_Homo sapiens_hsa040660.71857619
52Ribosome_Homo sapiens_hsa030100.71471283
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70842771
54Gastric acid secretion_Homo sapiens_hsa049710.70468915
55MAPK signaling pathway_Homo sapiens_hsa040100.70069345
56GnRH signaling pathway_Homo sapiens_hsa049120.70003871
57mTOR signaling pathway_Homo sapiens_hsa041500.64512908
58PPAR signaling pathway_Homo sapiens_hsa033200.64374739
59Renin secretion_Homo sapiens_hsa049240.59177289
60Insulin secretion_Homo sapiens_hsa049110.54031162
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51408581
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44975529
63RNA degradation_Homo sapiens_hsa030180.41489240
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41485996
65Salivary secretion_Homo sapiens_hsa049700.41068400
66Linoleic acid metabolism_Homo sapiens_hsa005910.38992878
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.38941705
68Platelet activation_Homo sapiens_hsa046110.38825307
69Butanoate metabolism_Homo sapiens_hsa006500.38406677
70Olfactory transduction_Homo sapiens_hsa047400.36817243
71Long-term potentiation_Homo sapiens_hsa047200.36368989
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36191363
73Type II diabetes mellitus_Homo sapiens_hsa049300.36099940
74Lysine degradation_Homo sapiens_hsa003100.33626949
75Renal cell carcinoma_Homo sapiens_hsa052110.32254553
76Amoebiasis_Homo sapiens_hsa051460.30756881
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30469476
78Proteoglycans in cancer_Homo sapiens_hsa052050.28991425
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28839061
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27453430
81beta-Alanine metabolism_Homo sapiens_hsa004100.27138424
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26316724
83Circadian entrainment_Homo sapiens_hsa047130.25037982
84Fatty acid elongation_Homo sapiens_hsa000620.24990613
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24829653
86Adherens junction_Homo sapiens_hsa045200.22320077
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22162506
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21792022
89Nitrogen metabolism_Homo sapiens_hsa009100.21626251
90Selenocompound metabolism_Homo sapiens_hsa004500.20501076
91Amphetamine addiction_Homo sapiens_hsa050310.19272075
92Peroxisome_Homo sapiens_hsa041460.19244829
93Sulfur metabolism_Homo sapiens_hsa009200.18583595
94Dorso-ventral axis formation_Homo sapiens_hsa043200.18437094
95ABC transporters_Homo sapiens_hsa020100.18094291
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17986079
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17935754
98RNA polymerase_Homo sapiens_hsa030200.17128223
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16280128
100Metabolic pathways_Homo sapiens_hsa011000.15530423
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.15376010
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.15161340
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15054980
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15049863
105Other glycan degradation_Homo sapiens_hsa005110.14745515
106Purine metabolism_Homo sapiens_hsa002300.14488401
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13553861
108Histidine metabolism_Homo sapiens_hsa003400.12876782
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12395389
110Long-term depression_Homo sapiens_hsa047300.12260804
111Phenylalanine metabolism_Homo sapiens_hsa003600.11515375
112Ovarian steroidogenesis_Homo sapiens_hsa049130.11468022
113T cell receptor signaling pathway_Homo sapiens_hsa046600.11438607
114Sulfur relay system_Homo sapiens_hsa041220.10876547
115Legionellosis_Homo sapiens_hsa051340.10654869
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09672445
117Prolactin signaling pathway_Homo sapiens_hsa049170.08556499
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.08383123
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08240167
120Pancreatic secretion_Homo sapiens_hsa049720.08075352
121Cholinergic synapse_Homo sapiens_hsa047250.06034320
122Acute myeloid leukemia_Homo sapiens_hsa052210.05351861
123Tryptophan metabolism_Homo sapiens_hsa003800.03286543

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