PPP1R21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.22161182
2central nervous system myelination (GO:0022010)6.22161182
3histone H3-K4 trimethylation (GO:0080182)5.29471334
4interleukin-6-mediated signaling pathway (GO:0070102)4.94965746
5neuron cell-cell adhesion (GO:0007158)4.49075594
6L-amino acid import (GO:0043092)4.43779103
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39832104
8negative regulation of cell killing (GO:0031342)4.39832104
9locomotory exploration behavior (GO:0035641)4.37848207
10synaptic vesicle maturation (GO:0016188)4.32773177
11regulation of B cell receptor signaling pathway (GO:0050855)4.24051014
12axon ensheathment (GO:0008366)4.16973585
13ensheathment of neurons (GO:0007272)4.16973585
14myelination (GO:0042552)4.16967422
15positive regulation of gamma-delta T cell activation (GO:0046645)4.04527973
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.87744235
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.87744235
18modulation by symbiont of host immune response (GO:0052553)3.87744235
19positive regulation by symbiont of host defense response (GO:0052509)3.87744235
20modulation by symbiont of host defense response (GO:0052031)3.87744235
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.87744235
22epithelial cell fate commitment (GO:0072148)3.78305486
23fatty acid elongation (GO:0030497)3.76657574
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71343806
25synaptic vesicle exocytosis (GO:0016079)3.70960784
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69102813
27peptidyl-lysine trimethylation (GO:0018023)3.61108534
28long-chain fatty acid biosynthetic process (GO:0042759)3.60008807
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57234425
30presynaptic membrane assembly (GO:0097105)3.54746030
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.52792960
32neuronal action potential propagation (GO:0019227)3.51660025
33negative regulation of neurotransmitter transport (GO:0051589)3.50410329
34presynaptic membrane organization (GO:0097090)3.48647548
35regulation of synaptic vesicle exocytosis (GO:2000300)3.45244242
36transmission of nerve impulse (GO:0019226)3.43750434
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.43066725
38macrophage activation involved in immune response (GO:0002281)3.42436403
39glutamate secretion (GO:0014047)3.40939293
40amino acid import (GO:0043090)3.38354110
41neutrophil activation involved in immune response (GO:0002283)3.37862315
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.36365401
43microglial cell activation (GO:0001774)3.34384983
44myelin maintenance (GO:0043217)3.33853419
45protein targeting to Golgi (GO:0000042)3.33398068
46adult walking behavior (GO:0007628)3.32884343
47negative regulation of neurotransmitter secretion (GO:0046929)3.32465666
48dendritic spine morphogenesis (GO:0060997)3.32293925
49negative regulation of interleukin-17 production (GO:0032700)3.32183696
50B cell receptor signaling pathway (GO:0050853)3.29498413
51establishment of protein localization to Golgi (GO:0072600)3.22211207
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21342932
53regulation of cell maturation (GO:1903429)3.20372805
54vocalization behavior (GO:0071625)3.16640843
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.16555804
56cellular extravasation (GO:0045123)3.15327320
57activated T cell proliferation (GO:0050798)3.13803360
58positive thymic T cell selection (GO:0045059)3.10295882
59mating behavior (GO:0007617)3.09109120
60detection of molecule of bacterial origin (GO:0032490)3.07915534
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06355355
62response to methylmercury (GO:0051597)3.03059622
63antigen processing and presentation of endogenous antigen (GO:0019883)3.02411321
64gamma-aminobutyric acid transport (GO:0015812)3.00238791
65regulation of interferon-beta biosynthetic process (GO:0045357)2.99550595
66neutrophil mediated immunity (GO:0002446)2.98333031
67positive T cell selection (GO:0043368)2.98187877
68exploration behavior (GO:0035640)2.97784075
69regulation of neuronal synaptic plasticity (GO:0048168)2.96706208
70regulation of glutamate receptor signaling pathway (GO:1900449)2.96540318
71cellular response to ethanol (GO:0071361)2.95566902
72gamma-aminobutyric acid signaling pathway (GO:0007214)2.94656236
73glutamate receptor signaling pathway (GO:0007215)2.94593493
74detection of other organism (GO:0098543)2.93711950
75nerve growth factor signaling pathway (GO:0038180)2.93152619
76neurotransmitter-gated ion channel clustering (GO:0072578)2.92115215
77regulation of beta-amyloid formation (GO:1902003)2.91571998
78protein localization to synapse (GO:0035418)2.90903558
79negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.89527742
80myeloid leukocyte mediated immunity (GO:0002444)2.89242973
81centrosome localization (GO:0051642)2.88815826
82dendrite morphogenesis (GO:0048813)2.88803467
83glycerophospholipid catabolic process (GO:0046475)2.88697519
84phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87607442
85regulation of synaptic vesicle transport (GO:1902803)2.86095498
86neurotransmitter secretion (GO:0007269)2.85349717
87cerebellar granule cell differentiation (GO:0021707)2.84624581
88regulation of long-term neuronal synaptic plasticity (GO:0048169)2.84397812
89clathrin coat assembly (GO:0048268)2.83474766
90glycine transport (GO:0015816)2.83095612
91regulation of amyloid precursor protein catabolic process (GO:1902991)2.82802725
92positive regulation of oligodendrocyte differentiation (GO:0048714)2.82146030
93neuronal ion channel clustering (GO:0045161)2.81959411
94macrophage activation (GO:0042116)2.81811838
95oligodendrocyte differentiation (GO:0048709)2.81346964
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81306054
97neuron recognition (GO:0008038)2.80515516
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80006004
99regulation of collateral sprouting (GO:0048670)2.79882396
100establishment of mitochondrion localization (GO:0051654)2.79871839
101negative thymic T cell selection (GO:0045060)2.79648186
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79389613
103negative regulation of lymphocyte mediated immunity (GO:0002707)2.79247278
104positive regulation of histone H3-K4 methylation (GO:0051571)2.79196464
105long-term synaptic potentiation (GO:0060291)2.78798738
106defense response to protozoan (GO:0042832)2.78531211
107regulation of gamma-delta T cell activation (GO:0046643)2.77765490
108regulation of B cell differentiation (GO:0045577)2.76794734
109protein localization to microtubule cytoskeleton (GO:0072698)2.75922160
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75586805
111histone H3-K4 methylation (GO:0051568)2.74826786
112negative regulation of axonogenesis (GO:0050771)2.74638544
113negative T cell selection (GO:0043383)2.71442349
114neuron-neuron synaptic transmission (GO:0007270)2.70615378
115detection of external biotic stimulus (GO:0098581)2.69587039
116regulation of fibroblast apoptotic process (GO:2000269)2.68692299
117positive regulation of membrane potential (GO:0045838)2.67649887
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67466620
119regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67400532
120regulation of synapse structural plasticity (GO:0051823)2.66593137
121neutrophil activation (GO:0042119)2.65838312
122synaptic transmission, glutamatergic (GO:0035249)2.65619297
123negative regulation of fibroblast apoptotic process (GO:2000270)2.65407087
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.64593321
125positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63478712
126neurotransmitter transport (GO:0006836)2.62285308
127positive regulation of Rap GTPase activity (GO:0032854)2.62042603
128vesicle transport along microtubule (GO:0047496)2.61711677
129regulation of ARF protein signal transduction (GO:0032012)2.60682239
130immunoglobulin mediated immune response (GO:0016064)2.60306227
131long-term memory (GO:0007616)2.60211803
132cell wall macromolecule catabolic process (GO:0016998)2.59611218
133positive regulation of B cell differentiation (GO:0045579)2.58899560
134prepulse inhibition (GO:0060134)2.58359774
135response to host immune response (GO:0052572)2.57519827
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57519827
137negative regulation of granulocyte differentiation (GO:0030853)2.57488578
138regulation of granulocyte differentiation (GO:0030852)2.57204986
139regulation of gamma-delta T cell differentiation (GO:0045586)2.56709922
140myeloid cell activation involved in immune response (GO:0002275)2.56399729
141neuromuscular process controlling balance (GO:0050885)2.55625104
142regulation of gene expression by genetic imprinting (GO:0006349)2.54758488
143detection of bacterium (GO:0016045)2.54675822
144axonal fasciculation (GO:0007413)2.53220024
145regulation of synaptic plasticity (GO:0048167)2.52001155
146substantia nigra development (GO:0021762)2.51894666
147layer formation in cerebral cortex (GO:0021819)2.51847658
148regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51345685
149neuron fate determination (GO:0048664)2.50389126
150I-kappaB phosphorylation (GO:0007252)2.49894210
151regulation of voltage-gated calcium channel activity (GO:1901385)2.49471176
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48471420
153interkinetic nuclear migration (GO:0022027)2.48072160
154organelle transport along microtubule (GO:0072384)2.47385953
155regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.47224076
156L-glutamate transport (GO:0015813)2.47120252
157positive regulation of cellular amide metabolic process (GO:0034250)2.47097197
158regulation of acrosome reaction (GO:0060046)2.47095588
159amyloid precursor protein metabolic process (GO:0042982)2.46986153
160synaptic vesicle endocytosis (GO:0048488)2.46847420
161regulation of clathrin-mediated endocytosis (GO:2000369)2.46544820
162regulation of postsynaptic membrane potential (GO:0060078)2.46307046
163acidic amino acid transport (GO:0015800)2.46043841
164neuromuscular process controlling posture (GO:0050884)2.45284255
165import into cell (GO:0098657)2.44913923
166regulation of neurotransmitter levels (GO:0001505)2.43502689
167cellular potassium ion homeostasis (GO:0030007)2.42861760
168astrocyte differentiation (GO:0048708)2.42331705
169cortical actin cytoskeleton organization (GO:0030866)2.42163698
170creatine metabolic process (GO:0006600)2.41480709
171histone H3-K9 demethylation (GO:0033169)2.41195589
172regulation of dendritic spine morphogenesis (GO:0061001)2.40183390
173regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40130693
174regulation of Rap GTPase activity (GO:0032317)2.40041512
175regulation of dendritic spine development (GO:0060998)2.39600328
176interferon-gamma-mediated signaling pathway (GO:0060333)2.39207131
177response to interleukin-15 (GO:0070672)2.39044849
178activation of protein kinase A activity (GO:0034199)2.38804336
179negative regulation of T cell mediated immunity (GO:0002710)2.37422613
180protein localization to cytoskeleton (GO:0044380)2.37356811
181negative regulation of protein oligomerization (GO:0032460)2.36462446
182detection of temperature stimulus involved in sensory perception (GO:0050961)2.36142836
183detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.36142836
184positive regulation of granulocyte differentiation (GO:0030854)2.35772914
185regulation of natural killer cell mediated immunity (GO:0002715)2.35764533
186regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.35764533
187acrosome reaction (GO:0007340)2.30190908
188detection of biotic stimulus (GO:0009595)2.29754878
189genetic imprinting (GO:0071514)2.29297325
190cellular response to interleukin-15 (GO:0071350)2.28683627
191positive regulation of mast cell activation (GO:0033005)2.28262062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.20697592
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.20572352
3EZH2_22144423_ChIP-Seq_EOC_Human3.14001885
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92918645
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61987053
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.56209800
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.53233583
8DROSHA_22980978_ChIP-Seq_HELA_Human2.52099473
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48356693
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.32902518
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30317443
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24328216
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16797030
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13719058
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09814008
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09814008
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05554638
18REST_21632747_ChIP-Seq_MESCs_Mouse2.02482433
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01110004
20AR_21572438_ChIP-Seq_LNCaP_Human2.00311585
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99129560
22TAF15_26573619_Chip-Seq_HEK293_Human1.86912294
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86012206
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84008112
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82962932
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81925504
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79907691
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.77330726
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.75187177
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67465324
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.67010415
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.66516579
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66100840
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57115948
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55070808
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55033947
37BCAT_22108803_ChIP-Seq_LS180_Human1.53858255
38SCL_19346495_ChIP-Seq_HPC-7_Human1.51417847
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51172903
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48707734
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.47341870
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45355654
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44930280
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44732024
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40499299
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39913894
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37804441
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.36663046
49SMAD4_21799915_ChIP-Seq_A2780_Human1.35279642
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34766486
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34499571
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.34329819
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33965971
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.33527223
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.33059482
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32507523
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32316260
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32250099
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31377359
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31052698
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29745589
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28523509
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28234598
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27722032
65GATA3_27048872_Chip-Seq_THYMUS_Human1.27513369
66AHR_22903824_ChIP-Seq_MCF-7_Human1.26833178
67ER_23166858_ChIP-Seq_MCF-7_Human1.26518913
68GATA1_22025678_ChIP-Seq_K562_Human1.26065516
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24210724
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23667218
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22634522
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21956345
73SPI1_23127762_ChIP-Seq_K562_Human1.21841754
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.20472759
75P300_19829295_ChIP-Seq_ESCs_Human1.20204117
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19916386
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19910095
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.19750515
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18820924
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17902931
81STAT3_23295773_ChIP-Seq_U87_Human1.17406863
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17258892
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15017177
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14624694
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14315966
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.13902511
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13060343
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.12890677
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12035359
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.11325568
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10710835
92P53_22387025_ChIP-Seq_ESCs_Mouse1.10272833
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10189223
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.09720068
95RUNX_20019798_ChIP-Seq_JUKART_Human1.09279655
96CBP_20019798_ChIP-Seq_JUKART_Human1.08845154
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08845154
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08831405
99IGF1R_20145208_ChIP-Seq_DFB_Human1.08446161
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08311134
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07701182
102SMRT_27268052_Chip-Seq_Bcells_Human1.07617194
103MYB_26560356_Chip-Seq_TH2_Human1.07512601
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06899160
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.05461481
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.04317887
107TCF4_23295773_ChIP-Seq_U87_Human1.04145806
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03887610
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03448499
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02681380
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01122267
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00662391
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00002082
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.99933571
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99875776
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99570147
117AR_25329375_ChIP-Seq_VCAP_Human0.99460844
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98915495
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98188011
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98188011
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.97802696
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.97800678
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97724190
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96365063
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96309570
126TCF4_22108803_ChIP-Seq_LS180_Human0.95732266
127KDM2B_26808549_Chip-Seq_K562_Human0.94505728
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94096389
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94030128
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.94027674
131AR_19668381_ChIP-Seq_PC3_Human0.92895310
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.92372662
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92228971
134TP53_16413492_ChIP-PET_HCT116_Human0.91857153
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91335116
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91335116
137IRF8_27001747_Chip-Seq_BMDM_Mouse0.90422328
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89692134
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88770116
140WT1_19549856_ChIP-ChIP_CCG9911_Human0.88713170
141RUNX2_22187159_ChIP-Seq_PCA_Human0.88355601
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.87615134
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87281466
144VDR_24787735_ChIP-Seq_THP-1_Human0.86948298
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84642343
146SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83885419
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.82713749
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.82156268
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.81866324
150GATA1_19941826_ChIP-Seq_K562_Human0.81830250
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.81218407
152PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81184706
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80070621
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79385580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.79865392
2MP0003880_abnormal_central_pattern4.64035247
3MP0000920_abnormal_myelination3.67520195
4MP0008877_abnormal_DNA_methylation3.49179440
5MP0003635_abnormal_synaptic_transmissio3.31212782
6MP0002064_seizures3.19727520
7MP0004270_analgesia3.18394420
8MP0003690_abnormal_glial_cell3.05029990
9MP0009745_abnormal_behavioral_response2.92349147
10MP0003329_amyloid_beta_deposits2.76882764
11MP0003724_increased_susceptibility_to2.71938296
12MP0002272_abnormal_nervous_system2.67516607
13MP0001835_abnormal_antigen_presentation2.67040254
14MP0001486_abnormal_startle_reflex2.66847249
15MP0005423_abnormal_somatic_nervous2.65210352
16MP0009046_muscle_twitch2.64509993
17MP0002063_abnormal_learning/memory/cond2.54475975
18MP0004885_abnormal_endolymph2.39762091
19MP0005671_abnormal_response_to2.35815517
20MP0002572_abnormal_emotion/affect_behav2.32169377
21MP0008057_abnormal_DNA_replication2.27632538
22MP0002822_catalepsy2.27108921
23MP0001968_abnormal_touch/_nociception2.24854715
24MP0001529_abnormal_vocalization2.24293641
25MP0003122_maternal_imprinting2.22442419
26MP0001905_abnormal_dopamine_level2.21637026
27MP0003195_calcinosis2.14360077
28MP0003300_gastrointestinal_ulcer2.10057558
29MP0003172_abnormal_lysosome_physiology2.04121635
30MP0003634_abnormal_glial_cell2.01806089
31MP0002734_abnormal_mechanical_nocicepti1.98210551
32MP0005058_abnormal_lysosome_morphology1.97758891
33MP0008569_lethality_at_weaning1.95895246
34MP0000685_abnormal_immune_system1.95002844
35MP0001440_abnormal_grooming_behavior1.94939946
36MP0000604_amyloidosis1.94516318
37MP0001800_abnormal_humoral_immune1.93234168
38MP0002736_abnormal_nociception_after1.86851919
39MP0004742_abnormal_vestibular_system1.84373029
40MP0000778_abnormal_nervous_system1.83450292
41MP0002067_abnormal_sensory_capabilities1.80506101
42MP0001970_abnormal_pain_threshold1.76979056
43MP0003633_abnormal_nervous_system1.75894759
44MP0002735_abnormal_chemical_nociception1.75080479
45MP0004142_abnormal_muscle_tone1.74961239
46MP0001501_abnormal_sleep_pattern1.74669220
47MP0002733_abnormal_thermal_nociception1.73905684
48MP0004924_abnormal_behavior1.68427653
49MP0005386_behavior/neurological_phenoty1.68427653
50MP0003121_genomic_imprinting1.67569866
51MP0009785_altered_susceptibility_to1.66295872
52MP0005025_abnormal_response_to1.64718767
53MP0002229_neurodegeneration1.62921567
54MP0003632_abnormal_nervous_system1.62529057
55MP0003631_nervous_system_phenotype1.61927072
56MP0005409_darkened_coat_color1.54185506
57MP0002723_abnormal_immune_serum1.52795726
58MP0001986_abnormal_taste_sensitivity1.50955249
59MP0002420_abnormal_adaptive_immunity1.45681716
60MP0003045_fibrosis1.45657451
61MP0002066_abnormal_motor_capabilities/c1.43881491
62MP0003436_decreased_susceptibility_to1.43057624
63MP0001819_abnormal_immune_cell1.41980601
64MP0002452_abnormal_antigen_presenting1.41683954
65MP0000955_abnormal_spinal_cord1.41433250
66MP0003183_abnormal_peptide_metabolism1.37769385
67MP0002882_abnormal_neuron_morphology1.35859498
68MP0002405_respiratory_system_inflammati1.31402413
69MP0004811_abnormal_neuron_physiology1.29371533
70MP0002557_abnormal_social/conspecific_i1.25336344
71MP0003828_pulmonary_edema1.24973716
72MP0003075_altered_response_to1.18200864
73MP0000015_abnormal_ear_pigmentation1.17351489
74MP0004883_abnormal_blood_vessel1.16685499
75MP0009780_abnormal_chondrocyte_physiolo1.16657534
76MP0005645_abnormal_hypothalamus_physiol1.16444005
77MP0008874_decreased_physiological_sensi1.14735175
78MP0003252_abnormal_bile_duct1.14439397
79MP0004858_abnormal_nervous_system1.14321374
80MP0002090_abnormal_vision1.13257629
81MP0005646_abnormal_pituitary_gland1.13113683
82MP0000716_abnormal_immune_system1.11628846
83MP0003303_peritoneal_inflammation1.11599908
84MP0002184_abnormal_innervation1.11373852
85MP0005174_abnormal_tail_pigmentation1.09568002
86MP0002398_abnormal_bone_marrow1.07567982
87MP0001984_abnormal_olfaction1.07258036
88MP0005171_absent_coat_pigmentation1.07182073
89MP0003763_abnormal_thymus_physiology1.05672860
90MP0002876_abnormal_thyroid_physiology1.05366125
91MP0005310_abnormal_salivary_gland1.04842991
92MP0002148_abnormal_hypersensitivity_rea1.04186762
93MP0003866_abnormal_defecation1.01081648
94MP0000689_abnormal_spleen_morphology1.00987800
95MP0001485_abnormal_pinna_reflex1.00416888
96MP0002693_abnormal_pancreas_physiology1.00048148
97MP0001963_abnormal_hearing_physiology0.99707783
98MP0010155_abnormal_intestine_physiology0.98838505
99MP0010234_abnormal_vibrissa_follicle0.98002097
100MP0002152_abnormal_brain_morphology0.96455489
101MP0000383_abnormal_hair_follicle0.95796419
102MP0001845_abnormal_inflammatory_respons0.95612092
103MP0003787_abnormal_imprinting0.94389496
104MP0005551_abnormal_eye_electrophysiolog0.94114290
105MP0001533_abnormal_skeleton_physiology0.94079111
106MP0002277_abnormal_respiratory_mucosa0.93796626
107MP0001502_abnormal_circadian_rhythm0.93787222
108MP0006276_abnormal_autonomic_nervous0.93160130
109MP0000465_gastrointestinal_hemorrhage0.91610976
110MP0000569_abnormal_digit_pigmentation0.90924771
111MP0004043_abnormal_pH_regulation0.90282960
112MP0001851_eye_inflammation0.89883944
113MP0002928_abnormal_bile_duct0.87757581
114MP0001177_atelectasis0.84324751
115MP0005075_abnormal_melanosome_morpholog0.83266266
116MP0003879_abnormal_hair_cell0.81931234
117MP0002168_other_aberrant_phenotype0.81586840
118MP0003656_abnormal_erythrocyte_physiolo0.80368804
119MP0002069_abnormal_eating/drinking_beha0.80257416
120MP0002722_abnormal_immune_system0.79168153
121MP0009764_decreased_sensitivity_to0.77966466
122MP0010329_abnormal_lipoprotein_level0.77945361
123MP0009765_abnormal_xenobiotic_induced0.77904939
124MP0002909_abnormal_adrenal_gland0.77425073
125MP0005365_abnormal_bile_salt0.77278954
126MP0005535_abnormal_body_temperature0.77135004
127MP0001188_hyperpigmentation0.76946785
128MP0004510_myositis0.74745661
129MP0006082_CNS_inflammation0.74128044
130MP0000747_muscle_weakness0.71065199
131MP0002752_abnormal_somatic_nervous0.70567246
132MP0005167_abnormal_blood-brain_barrier0.69248777
133MP0010386_abnormal_urinary_bladder0.68137579
134MP0005584_abnormal_enzyme/coenzyme_acti0.68045009
135MP0005623_abnormal_meninges_morphology0.66866774
136MP0001661_extended_life_span0.65980933
137MP0008872_abnormal_physiological_respon0.65531907
138MP0010678_abnormal_skin_adnexa0.65060974
139MP0004134_abnormal_chest_morphology0.62864001
140MP0005387_immune_system_phenotype0.59250429
141MP0001790_abnormal_immune_system0.59250429
142MP0005000_abnormal_immune_tolerance0.55588305
143MP0009840_abnormal_foam_cell0.55234318
144MP0004147_increased_porphyrin_level0.55221987
145MP0000639_abnormal_adrenal_gland0.55173087
146MP0002419_abnormal_innate_immunity0.54486279
147MP0001765_abnormal_ion_homeostasis0.53886041
148MP0008260_abnormal_autophagy0.52560248
149MP0001943_abnormal_respiration0.49908747
150MP0001299_abnormal_eye_distance/0.49459399
151MP0003136_yellow_coat_color0.49308866
152MP0005464_abnormal_platelet_physiology0.48445111

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.56942378
2Myokymia (HP:0002411)4.97837191
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.64611762
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.64611762
5Supranuclear gaze palsy (HP:0000605)4.54284051
6Cerebral inclusion bodies (HP:0100314)4.54264271
7Volvulus (HP:0002580)4.43296134
8Focal motor seizures (HP:0011153)4.29800766
9Recurrent bacterial skin infections (HP:0005406)4.06089261
10Abnormality of the corticospinal tract (HP:0002492)3.99073579
11Papillary thyroid carcinoma (HP:0002895)3.81043293
12Recurrent abscess formation (HP:0002722)3.74609962
13Intention tremor (HP:0002080)3.73936966
14Spastic gait (HP:0002064)3.61883731
15Dysmetria (HP:0001310)3.53952304
16Peripheral hypomyelination (HP:0007182)3.52636254
17Eczematoid dermatitis (HP:0000976)3.50702018
18Focal seizures (HP:0007359)3.45229711
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.33344145
20Atonic seizures (HP:0010819)3.30087470
21Termporal pattern (HP:0011008)3.27271089
22Insidious onset (HP:0003587)3.27271089
23Constricted visual fields (HP:0001133)3.24643876
24Onion bulb formation (HP:0003383)3.20455931
25Sensory axonal neuropathy (HP:0003390)3.18696249
26Visual hallucinations (HP:0002367)3.17697294
27Abnormality of macrophages (HP:0004311)3.13150556
28Ankle clonus (HP:0011448)3.12496186
29Recurrent gram-negative bacterial infections (HP:0005420)3.09142331
30Mutism (HP:0002300)3.02097381
31Increased cerebral lipofuscin (HP:0011813)3.01637257
32Action tremor (HP:0002345)2.98490218
33Optic neuritis (HP:0100653)2.93228603
34Retrobulbar optic neuritis (HP:0100654)2.93228603
35Gingival bleeding (HP:0000225)2.92466092
36T lymphocytopenia (HP:0005403)2.90549540
37Recurrent fungal infections (HP:0002841)2.88638329
38Akinesia (HP:0002304)2.85431851
39Thyroiditis (HP:0100646)2.85021693
40Truncal obesity (HP:0001956)2.84939755
41Neuronal loss in central nervous system (HP:0002529)2.82731434
42Increased circulating renin level (HP:0000848)2.81885055
43Genetic anticipation (HP:0003743)2.81464575
44Spastic tetraparesis (HP:0001285)2.81234967
45Abnormal eating behavior (HP:0100738)2.79603833
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.77984694
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.76766343
48Stomatitis (HP:0010280)2.74667455
49Abnormality of T cell number (HP:0011839)2.74565249
50Recurrent skin infections (HP:0001581)2.72324427
51Postural instability (HP:0002172)2.70208129
52Hyperventilation (HP:0002883)2.66489770
53Orchitis (HP:0100796)2.64564040
54Epileptic encephalopathy (HP:0200134)2.63237345
55Scanning speech (HP:0002168)2.63041862
56Chronic mucocutaneous candidiasis (HP:0002728)2.61713891
57Recurrent cutaneous fungal infections (HP:0011370)2.61713891
58Urinary bladder sphincter dysfunction (HP:0002839)2.58304217
59Abnormality of binocular vision (HP:0011514)2.57260441
60Diplopia (HP:0000651)2.57260441
61Thyroid carcinoma (HP:0002890)2.56375638
62Spontaneous hematomas (HP:0007420)2.54785001
63Progressive cerebellar ataxia (HP:0002073)2.54368028
64Meningitis (HP:0001287)2.53049209
65Abnormal auditory evoked potentials (HP:0006958)2.52691233
66Myositis (HP:0100614)2.52300582
67Pheochromocytoma (HP:0002666)2.51460408
68Broad-based gait (HP:0002136)2.49928147
69Neoplasm of the tracheobronchial system (HP:0100552)2.47713929
70Cerebral hypomyelination (HP:0006808)2.46908949
71Metabolic alkalosis (HP:0200114)2.43490639
72Polyphagia (HP:0002591)2.40572088
73Urinary urgency (HP:0000012)2.37047006
74Limb dystonia (HP:0002451)2.36415079
75Dialeptic seizures (HP:0011146)2.36197430
76Absence seizures (HP:0002121)2.35739662
77Dysdiadochokinesis (HP:0002075)2.35516942
78Severe combined immunodeficiency (HP:0004430)2.34895184
79Generalized tonic-clonic seizures (HP:0002069)2.32521476
80Loss of speech (HP:0002371)2.31956633
81Clumsiness (HP:0002312)2.30718602
82Abnormality of eosinophils (HP:0001879)2.29978289
83Lower limb muscle weakness (HP:0007340)2.29609936
84Truncal ataxia (HP:0002078)2.29555976
85Parakeratosis (HP:0001036)2.29542933
86Anxiety (HP:0000739)2.28280196
87Hypokalemic alkalosis (HP:0001949)2.27801794
88Hypochromic microcytic anemia (HP:0004840)2.25034275
89Leukocytosis (HP:0001974)2.24757575
90Excessive salivation (HP:0003781)2.23855098
91Drooling (HP:0002307)2.23855098
92Slow saccadic eye movements (HP:0000514)2.23504186
93Macroorchidism (HP:0000053)2.23360239
94Progressive inability to walk (HP:0002505)2.22220868
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.21366130
96Vasculitis (HP:0002633)2.21043038
97Amyotrophic lateral sclerosis (HP:0007354)2.18596234
98Depression (HP:0000716)2.16192926
99Psychosis (HP:0000709)2.16081029
100Mediastinal lymphadenopathy (HP:0100721)2.15635154
101Panhypogammaglobulinemia (HP:0003139)2.15596536
102Gastrointestinal infarctions (HP:0005244)2.14033454
103Axonal loss (HP:0003447)2.13969326
104Keratoconjunctivitis (HP:0001096)2.12438820
105Hypoplasia of the thymus (HP:0000778)2.12300225
106Impaired vibratory sensation (HP:0002495)2.12291088
107Clonus (HP:0002169)2.09641409
108Impaired vibration sensation in the lower limbs (HP:0002166)2.08760323
109Abnormality of liposaccharide metabolism (HP:0010968)2.08413702
110Abnormality of glycosphingolipid metabolism (HP:0004343)2.08413702
111Abnormality of glycolipid metabolism (HP:0010969)2.08413702
112Dysostosis multiplex (HP:0000943)2.08148698
113Toxemia of pregnancy (HP:0100603)2.08132071
114Febrile seizures (HP:0002373)2.07169184
115Papilledema (HP:0001085)2.06911999
116Widely spaced teeth (HP:0000687)2.05270775
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04933114
118Neuroendocrine neoplasm (HP:0100634)2.04379229
119Systemic lupus erythematosus (HP:0002725)2.04277918
120Gingivitis (HP:0000230)2.04078424
121Gaze-evoked nystagmus (HP:0000640)2.03565117
122Generalized myoclonic seizures (HP:0002123)2.02658297
123Keratoconjunctivitis sicca (HP:0001097)2.02552348
124Torticollis (HP:0000473)1.98209017
125Hemoptysis (HP:0002105)1.98044296
126Bowel incontinence (HP:0002607)1.97702164
127Cerebral hemorrhage (HP:0001342)1.97696836
128Abnormality of saccadic eye movements (HP:0000570)1.96887240
129Peripheral demyelination (HP:0011096)1.96562803
130Prolonged bleeding time (HP:0003010)1.96326751
131Recurrent bronchitis (HP:0002837)1.95076824
132Polygenic inheritance (HP:0010982)1.94015862
133Rigidity (HP:0002063)1.93373045
134Urinary incontinence (HP:0000020)1.92871091
135Chest pain (HP:0100749)1.92852737
136Blue irides (HP:0000635)1.91386284
137Pulmonary infiltrates (HP:0002113)1.89568469
138Segmental peripheral demyelination/remyelination (HP:0003481)1.89106283
139Apathy (HP:0000741)1.88927399
140Elevated erythrocyte sedimentation rate (HP:0003565)1.88166071
141CNS hypomyelination (HP:0003429)1.87772482
142Abnormality of T cells (HP:0002843)1.87691825
143Limb hypertonia (HP:0002509)1.87615243
144Abnormal hair whorl (HP:0010721)1.86907246
145Autoimmune thrombocytopenia (HP:0001973)1.86845020
146Pulmonary embolism (HP:0002204)1.86213518
147Abnormal large intestine physiology (HP:0012700)1.85341080
148Epistaxis (HP:0000421)1.84844289
149Thickened calvaria (HP:0002684)1.81967466
150Disinhibition (HP:0000734)1.81813105
151Rhabdomyosarcoma (HP:0002859)1.81735377
152Megalencephaly (HP:0001355)1.81103644
153Alacrima (HP:0000522)1.81086189
154Agnosia (HP:0010524)1.81008346
155Intrahepatic cholestasis (HP:0001406)1.80873131
156Hemiplegia (HP:0002301)1.80195028
157Chronic obstructive pulmonary disease (HP:0006510)1.79179557
158Obstructive lung disease (HP:0006536)1.79179557
159Rapidly progressive (HP:0003678)1.78843657
160Amyloidosis (HP:0011034)1.78383362
161Episodic fever (HP:0001954)1.77668471
162Urticaria (HP:0001025)1.77319597
163Low anterior hairline (HP:0000294)1.75941936
164Abnormality of the fingertips (HP:0001211)1.75355233
165Arterial tortuosity (HP:0005116)1.75008913
166Hypomagnesemia (HP:0002917)1.74642380
167Encephalitis (HP:0002383)1.74467767
168Morphological abnormality of the pyramidal tract (HP:0002062)1.73655350
169Abnormality of the prostate (HP:0008775)1.73517446
170Abnormality of salivation (HP:0100755)1.72648444
171Sepsis (HP:0100806)1.72424808
172Agitation (HP:0000713)1.71824492
173Partial agenesis of the corpus callosum (HP:0001338)1.71516574
174Lymphopenia (HP:0001888)1.69884840
175Eosinophilia (HP:0001880)1.69322720
176Combined immunodeficiency (HP:0005387)1.68329126
177Arterial thrombosis (HP:0004420)1.65191789
178Abnormality of B cell number (HP:0010975)1.65042757
179Agammaglobulinemia (HP:0004432)1.59951338
180Peritonitis (HP:0002586)1.59411421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR13.44901770
2STK393.26485386
3EPHA42.64635245
4MAP3K92.34820402
5NTRK32.23787827
6TAF12.22114401
7EPHB12.16619322
8RIPK42.13424317
9PRPF4B2.10529349
10FES2.09408834
11NTRK11.86664119
12PKN11.86271794
13CDK191.85263754
14TNIK1.81856661
15FGFR21.76656615
16MAP3K41.75565695
17MARK11.73453805
18TYRO31.68514749
19PIK3CG1.68500790
20PAK61.66125352
21SGK21.64168008
22FGR1.54899703
23MATK1.54159096
24CASK1.49635051
25MAP3K131.46715380
26TEC1.44747761
27UHMK11.44064237
28TRPM71.43937456
29MAPKAPK51.43906725
30PNCK1.42443261
31MINK11.40490685
32WNK11.40199553
33FRK1.35575968
34CDK51.35501261
35ARAF1.32510399
36TYK21.30553610
37NTRK21.29855240
38SGK4941.29764052
39SGK2231.29764052
40SGK31.29634293
41KSR21.29513655
42WNK41.24053051
43DAPK21.23782611
44ITK1.20026565
45GRK71.17628310
46BMPR21.17089863
47TXK1.16073871
48CSNK1G21.15774403
49ROCK21.14809162
50CAMK1G1.13206861
51NEK61.09385531
52CSNK1G31.08617610
53MAP3K21.07976291
54BTK1.07946173
55MAPK131.07869740
56CLK11.05892321
57CAMK2B1.05082742
58SIK21.04417954
59PAK31.03335972
60YES11.03102567
61CAMKK11.02511617
62IRAK41.02085691
63KIT1.00355074
64MAP3K140.98963205
65PDPK10.97329346
66PDK10.96620185
67FGFR30.96132790
68PRKCH0.94901697
69MAP3K120.94627246
70STK110.91753197
71BMPR1B0.91280232
72MARK20.91112165
73MAP4K10.89819960
74MET0.88411124
75FYN0.88372526
76KSR10.88202227
77MAP2K40.87893478
78IKBKE0.86542046
79PRKCQ0.86408290
80NLK0.85881512
81CDK140.85721489
82CDK150.83817754
83RET0.83397857
84MAPK150.82827513
85CDK180.79523004
86PLK20.78972020
87JAK20.78173637
88CSNK1A1L0.78085449
89NEK90.77946184
90LIMK10.76919786
91GRK50.74942861
92CAMK2A0.74931581
93LYN0.74812512
94CSNK1G10.74421711
95MAP2K70.73875678
96JAK10.73772594
97CDK11A0.73118837
98ICK0.72778857
99CSF1R0.71908477
100RAF10.70776513
101TNK20.69912453
102CAMK2D0.69082059
103MAP3K10.67170267
104PHKG20.66979449
105PHKG10.66979449
106PTK2B0.66607763
107MAP3K100.66422236
108TAOK30.66377880
109MAP2K30.60848657
110PDGFRB0.60720989
111BCR0.60646676
112CSK0.59951985
113GRK60.59749778
114CDK90.58304174
115HCK0.58173013
116BRAF0.57828289
117PRKD10.57700333
118JAK30.56923833
119CAMK2G0.56741730
120ZAP700.56059764
121STK380.54903646
122PRKCG0.54715494
123BLK0.53543336
124TESK20.51982365
125SGK10.51814808
126ALK0.51025585
127HIPK20.49578790
128CAMKK20.48578692
129DYRK1A0.48528217
130CDC42BPA0.47676366
131BMX0.47658526
132ADRBK20.47460632
133MAP3K70.47189060
134LCK0.45772537
135SYK0.44923186
136PRKCE0.44810208
137CSNK1D0.44158462
138PRKCZ0.43095701
139ACVR1B0.42708549
140CAMK1D0.42383450
141ABL10.40928123
142CAMK40.40543070
143PRKG10.39889836
144ERBB20.39045329
145PINK10.37583917
146RPS6KB10.35443814
147AKT30.33061302

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.48572918
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15824648
3GABAergic synapse_Homo sapiens_hsa047272.15688452
4Leishmaniasis_Homo sapiens_hsa051402.14138170
5Nicotine addiction_Homo sapiens_hsa050332.10651242
6Glutamatergic synapse_Homo sapiens_hsa047242.09955264
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.08762656
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96800964
9Morphine addiction_Homo sapiens_hsa050321.96008713
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92744490
11Type I diabetes mellitus_Homo sapiens_hsa049401.90985772
12Olfactory transduction_Homo sapiens_hsa047401.90560639
13Allograft rejection_Homo sapiens_hsa053301.89526999
14Steroid biosynthesis_Homo sapiens_hsa001001.85414888
15Collecting duct acid secretion_Homo sapiens_hsa049661.83862497
16Nitrogen metabolism_Homo sapiens_hsa009101.79058595
17Circadian entrainment_Homo sapiens_hsa047131.78434859
18Long-term potentiation_Homo sapiens_hsa047201.67424130
19Dopaminergic synapse_Homo sapiens_hsa047281.64642915
20Cholinergic synapse_Homo sapiens_hsa047251.62544432
21Salivary secretion_Homo sapiens_hsa049701.61181180
22Long-term depression_Homo sapiens_hsa047301.58870179
23Amphetamine addiction_Homo sapiens_hsa050311.55941509
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55188475
25Gastric acid secretion_Homo sapiens_hsa049711.53641273
26Serotonergic synapse_Homo sapiens_hsa047261.47718471
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46856529
28Autoimmune thyroid disease_Homo sapiens_hsa053201.44773257
29Cocaine addiction_Homo sapiens_hsa050301.44107900
30Axon guidance_Homo sapiens_hsa043601.37425733
31Ether lipid metabolism_Homo sapiens_hsa005651.37389625
32Graft-versus-host disease_Homo sapiens_hsa053321.37140507
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35823131
34Primary immunodeficiency_Homo sapiens_hsa053401.35095686
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35039038
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31791330
37Renin secretion_Homo sapiens_hsa049241.31528678
38Prolactin signaling pathway_Homo sapiens_hsa049171.28206460
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27948010
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26502414
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.25896948
42African trypanosomiasis_Homo sapiens_hsa051431.25274124
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20417966
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18730233
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18650114
46Vibrio cholerae infection_Homo sapiens_hsa051101.17305210
47B cell receptor signaling pathway_Homo sapiens_hsa046621.14999738
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14570686
49Lysosome_Homo sapiens_hsa041421.13417889
50Fatty acid elongation_Homo sapiens_hsa000621.13118812
51Renal cell carcinoma_Homo sapiens_hsa052111.12085657
52GnRH signaling pathway_Homo sapiens_hsa049121.11046633
53Acute myeloid leukemia_Homo sapiens_hsa052211.10768333
54Malaria_Homo sapiens_hsa051441.10634465
55ErbB signaling pathway_Homo sapiens_hsa040121.10123817
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.09698896
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09413515
58Oxytocin signaling pathway_Homo sapiens_hsa049211.09129793
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.07948938
60Gap junction_Homo sapiens_hsa045401.04910611
61Hematopoietic cell lineage_Homo sapiens_hsa046401.04281972
62Insulin secretion_Homo sapiens_hsa049111.03943864
63Measles_Homo sapiens_hsa051621.03628598
64Toxoplasmosis_Homo sapiens_hsa051451.03509623
65Asthma_Homo sapiens_hsa053101.02831976
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00706760
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99586714
68Choline metabolism in cancer_Homo sapiens_hsa052310.99562623
69Endocytosis_Homo sapiens_hsa041440.98799266
70Taste transduction_Homo sapiens_hsa047420.98305577
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.98065587
72Estrogen signaling pathway_Homo sapiens_hsa049150.95968638
73Glioma_Homo sapiens_hsa052140.95399445
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94554749
75Endometrial cancer_Homo sapiens_hsa052130.92208523
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91875592
77Type II diabetes mellitus_Homo sapiens_hsa049300.91865600
78Calcium signaling pathway_Homo sapiens_hsa040200.89556198
79Butanoate metabolism_Homo sapiens_hsa006500.88892148
80Legionellosis_Homo sapiens_hsa051340.88872496
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88093583
82Influenza A_Homo sapiens_hsa051640.87593776
83Chemokine signaling pathway_Homo sapiens_hsa040620.87083781
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.85131495
85cAMP signaling pathway_Homo sapiens_hsa040240.84994669
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81588599
87Regulation of autophagy_Homo sapiens_hsa041400.80591420
88Rheumatoid arthritis_Homo sapiens_hsa053230.80329856
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76871800
90mTOR signaling pathway_Homo sapiens_hsa041500.76855948
91ABC transporters_Homo sapiens_hsa020100.76431380
92Dorso-ventral axis formation_Homo sapiens_hsa043200.76190902
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75025508
94FoxO signaling pathway_Homo sapiens_hsa040680.74943714
95Phagosome_Homo sapiens_hsa041450.74465032
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73447571
97Pancreatic secretion_Homo sapiens_hsa049720.72018938
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.71966959
99Ras signaling pathway_Homo sapiens_hsa040140.71614948
100Sphingolipid metabolism_Homo sapiens_hsa006000.70758242
101Prion diseases_Homo sapiens_hsa050200.70412026
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69894024
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69724858
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.68763451
105Hepatitis C_Homo sapiens_hsa051600.68755600
106Viral myocarditis_Homo sapiens_hsa054160.68141454
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67753630
108VEGF signaling pathway_Homo sapiens_hsa043700.67502311
109T cell receptor signaling pathway_Homo sapiens_hsa046600.66874596
110Inositol phosphate metabolism_Homo sapiens_hsa005620.65930368
111Thyroid hormone synthesis_Homo sapiens_hsa049180.64986752
112Other glycan degradation_Homo sapiens_hsa005110.63515657
113MAPK signaling pathway_Homo sapiens_hsa040100.62290697
114Staphylococcus aureus infection_Homo sapiens_hsa051500.61081146
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60945507
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.59885628
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57558145
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.56774499
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56615055
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54355379
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54248980
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54182201
123Osteoclast differentiation_Homo sapiens_hsa043800.54178689
124TNF signaling pathway_Homo sapiens_hsa046680.53923598
125Non-small cell lung cancer_Homo sapiens_hsa052230.53800379
126Insulin resistance_Homo sapiens_hsa049310.53441891
127Platelet activation_Homo sapiens_hsa046110.53059111
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52864118
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46101244
130Bile secretion_Homo sapiens_hsa049760.45929679
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41278004
132Rap1 signaling pathway_Homo sapiens_hsa040150.40731859
133Melanogenesis_Homo sapiens_hsa049160.38999747
134Salmonella infection_Homo sapiens_hsa051320.37660669
135Ovarian steroidogenesis_Homo sapiens_hsa049130.36955577
136Tuberculosis_Homo sapiens_hsa051520.35322867
137Pertussis_Homo sapiens_hsa051330.34684747

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