PPP1R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of oxidative stress-induced neuron death (GO:1903203)6.24988559
2positive regulation of catecholamine secretion (GO:0033605)5.99934094
3response to muscle activity (GO:0014850)5.04802035
4regulation of autophagic vacuole assembly (GO:2000785)4.99295058
5regulation of vacuole organization (GO:0044088)4.68647226
6synaptic vesicle maturation (GO:0016188)4.53797487
7cellular response to zinc ion (GO:0071294)4.10757831
8regulation of oxidative phosphorylation (GO:0002082)4.09230528
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.06815779
10regulation of relaxation of muscle (GO:1901077)4.03523073
11motile cilium assembly (GO:0044458)4.02116341
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99031389
13* regulation of phosphoprotein phosphatase activity (GO:0043666)3.97793845
14negative regulation of dendrite morphogenesis (GO:0050774)3.94344915
15T-helper cell differentiation (GO:0042093)3.89514375
16CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.89514375
17neuronal action potential (GO:0019228)3.88819900
18TOR signaling (GO:0031929)3.82268600
19multicellular organism reproduction (GO:0032504)3.80765547
20AMP metabolic process (GO:0046033)3.78979253
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.78328832
22regulation of synaptic vesicle exocytosis (GO:2000300)3.77251394
23cellular response to interleukin-15 (GO:0071350)3.76907442
24ADP metabolic process (GO:0046031)3.75037605
25activation of protein kinase A activity (GO:0034199)3.72956758
26mitochondrion degradation (GO:0000422)3.63777417
27synaptic vesicle exocytosis (GO:0016079)3.63176360
28coenzyme catabolic process (GO:0009109)3.61814019
29regulation of synapse structural plasticity (GO:0051823)3.60066404
30positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59189089
31neuronal action potential propagation (GO:0019227)3.59140266
32negative regulation of cell killing (GO:0031342)3.56636477
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56636477
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.52035948
35cellular response to toxic substance (GO:0097237)3.49857911
36locomotory exploration behavior (GO:0035641)3.49432813
37glutamate secretion (GO:0014047)3.44854828
38regulation of early endosome to late endosome transport (GO:2000641)3.43718052
39male meiosis (GO:0007140)3.40384416
40membrane depolarization during action potential (GO:0086010)3.39504206
41alpha-beta T cell differentiation involved in immune response (GO:0002293)3.39146852
42alpha-beta T cell activation involved in immune response (GO:0002287)3.39146852
43T cell differentiation involved in immune response (GO:0002292)3.39146852
44cell communication involved in cardiac conduction (GO:0086065)3.38135600
45actin-myosin filament sliding (GO:0033275)3.34609173
46muscle filament sliding (GO:0030049)3.34609173
47regulation of dopamine secretion (GO:0014059)3.32721994
48layer formation in cerebral cortex (GO:0021819)3.31336580
49plasma membrane repair (GO:0001778)3.30732664
50tolerance induction (GO:0002507)3.29501076
51positive regulation of gamma-delta T cell activation (GO:0046645)3.28958563
52vesicle transport along microtubule (GO:0047496)3.27841018
53cellular potassium ion homeostasis (GO:0030007)3.25766995
54regulation of cellular respiration (GO:0043457)3.25091645
55response to interleukin-15 (GO:0070672)3.24153747
56activation of protein kinase B activity (GO:0032148)3.23964222
57proline transport (GO:0015824)3.21611773
58negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.21494719
59regulation of synaptic vesicle transport (GO:1902803)3.21473797
60relaxation of smooth muscle (GO:0044557)3.21282512
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19433818
62histone H3-K36 demethylation (GO:0070544)3.18891766
63dopamine receptor signaling pathway (GO:0007212)3.18450375
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14814163
65prepulse inhibition (GO:0060134)3.12397579
66membrane repolarization (GO:0086009)3.11132830
67muscle cell cellular homeostasis (GO:0046716)3.10843649
68regulation of germinal center formation (GO:0002634)3.10231882
69activated T cell proliferation (GO:0050798)3.08962828
70sodium ion export (GO:0071436)3.08218048
71acrosome reaction (GO:0007340)3.07484566
72peristalsis (GO:0030432)3.07032060
73urinary tract smooth muscle contraction (GO:0014848)3.05750572
74oligosaccharide biosynthetic process (GO:0009312)3.04533410
75myofibril assembly (GO:0030239)3.01283661
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98935759
77regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.98543906
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.97453963
79CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.96964754
80regulation of B cell receptor signaling pathway (GO:0050855)2.96913206
81regulation of hydrogen peroxide-induced cell death (GO:1903205)2.96591185
82negative regulation of T cell mediated immunity (GO:0002710)2.95988993
83detection of calcium ion (GO:0005513)2.93582174
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91987743
85positive regulation of granulocyte differentiation (GO:0030854)2.91950239
86negative regulation of cation channel activity (GO:2001258)2.91934032
87actin-mediated cell contraction (GO:0070252)2.91916635
88cell communication by electrical coupling (GO:0010644)2.91618667
89sperm motility (GO:0030317)2.91521604
90alpha-beta T cell differentiation (GO:0046632)2.90733078
91mating behavior (GO:0007617)2.89539377
92DNA double-strand break processing (GO:0000729)2.88737492
93vocalization behavior (GO:0071625)2.87212258
94bundle of His cell to Purkinje myocyte communication (GO:0086069)2.87092234
95cGMP-mediated signaling (GO:0019934)2.86110539
96regulation of gamma-delta T cell differentiation (GO:0045586)2.85652167
97neuronal ion channel clustering (GO:0045161)2.85013197
98neurotransmitter secretion (GO:0007269)2.82522043
99striatum development (GO:0021756)2.82303294
100negative regulation of dendrite development (GO:2000171)2.81810573
101negative regulation of response to reactive oxygen species (GO:1901032)2.81720664
102detection of temperature stimulus (GO:0016048)2.81395044
103detection of temperature stimulus involved in sensory perception (GO:0050961)2.81155798
104detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.81155798
105positive regulation of potassium ion transport (GO:0043268)2.79349919
106regulation of neuronal synaptic plasticity (GO:0048168)2.78779886
107regulation of long-term neuronal synaptic plasticity (GO:0048169)2.77873322
108protein maturation by protein folding (GO:0022417)2.77635456
109mast cell activation (GO:0045576)2.77267946
110negative regulation of calcium ion transmembrane transport (GO:1903170)2.76877075
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.76877075
112neuromuscular process controlling balance (GO:0050885)2.76249607
113phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76010577
114organelle transport along microtubule (GO:0072384)2.75660843
115regulation of cAMP-dependent protein kinase activity (GO:2000479)2.75471797
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74112463
117cellular response to calcium ion (GO:0071277)2.72618522
118positive regulation of vesicle fusion (GO:0031340)2.72293320
119positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.72138206
120cytoplasmic mRNA processing body assembly (GO:0033962)2.71608523
121regulation of synaptic transmission, dopaminergic (GO:0032225)2.71403639
122innervation (GO:0060384)2.70311111
123synaptic transmission, dopaminergic (GO:0001963)2.69353232
124protein K63-linked deubiquitination (GO:0070536)2.69295968
125negative T cell selection (GO:0043383)2.68301935
126positive regulation of cardiac muscle hypertrophy (GO:0010613)2.68217689
127positive regulation of muscle hypertrophy (GO:0014742)2.68217689
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67446721
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.66752683
130regulation of alpha-beta T cell proliferation (GO:0046640)2.66547853
131potassium ion export (GO:0071435)2.66520804
132sarcomere organization (GO:0045214)2.65780790
133negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.65050937
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.63412451
135regulation of sodium ion transmembrane transporter activity (GO:2000649)2.63192618
136regulation of T cell mediated cytotoxicity (GO:0001914)2.61690211
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61211245
138protein targeting to plasma membrane (GO:0072661)2.60137645
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.59913057
140action potential (GO:0001508)2.59764673
141regulation of gamma-delta T cell activation (GO:0046643)2.59555052
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59412207
143negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59092322
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58675197
145positive regulation of glycolytic process (GO:0045821)2.57782130
146positive regulation of alpha-beta T cell proliferation (GO:0046641)2.56651988
147negative regulation of T cell apoptotic process (GO:0070233)2.56576837
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.56507914
149regulation of regulatory T cell differentiation (GO:0045589)2.56406557
150lymph node development (GO:0048535)2.56274387
151CD4-positive, alpha-beta T cell activation (GO:0035710)2.55271730
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54425457
153membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53615154
154regulation of dendritic spine morphogenesis (GO:0061001)2.52843257
155membrane budding (GO:0006900)2.51356869
156nucleoside diphosphate biosynthetic process (GO:0009133)2.51304721
157regulation of calcium ion transmembrane transporter activity (GO:1901019)2.50422836
158regulation of calcium ion transmembrane transport (GO:1903169)2.50422836
159cellular sodium ion homeostasis (GO:0006883)2.50300675
160regulation of voltage-gated calcium channel activity (GO:1901385)2.50229889
161neuromuscular synaptic transmission (GO:0007274)2.50208062
162negative regulation of ion transmembrane transporter activity (GO:0032413)2.50159415
163alpha-beta T cell activation (GO:0046631)2.49724033
164adenosine receptor signaling pathway (GO:0001973)2.49429298
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49317461
166positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49261632
167spermatid development (GO:0007286)2.48997049
168skeletal muscle contraction (GO:0003009)2.48732509
169regulation of membrane repolarization (GO:0060306)2.48520215
170regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.48305896
171T cell receptor signaling pathway (GO:0050852)2.48180517
172protein localization to endosome (GO:0036010)2.47272105
173T cell selection (GO:0045058)2.46436785
174reproduction (GO:0000003)2.46353849
175calcium ion-dependent exocytosis (GO:0017156)2.46111097
176exploration behavior (GO:0035640)2.45876959
177antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45502103
178regulation of myoblast differentiation (GO:0045661)2.45470573
179regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.45413319
180epithelial cilium movement (GO:0003351)2.45386623
181protein localization to synapse (GO:0035418)2.45239327
182regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.44848656
183regulation of amyloid precursor protein catabolic process (GO:1902991)2.44609729
184negative thymic T cell selection (GO:0045060)2.44425013
185axon cargo transport (GO:0008088)2.44337069
186potassium ion import (GO:0010107)2.43495749
187positive regulation of calcium-mediated signaling (GO:0050850)2.43372348
188regulation of protein kinase A signaling (GO:0010738)2.43353572
189regulation of glutamate receptor signaling pathway (GO:1900449)2.43280516
190regulation of potassium ion transmembrane transport (GO:1901379)2.42365319
191positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.41825310
192peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.41710764
193positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.41665606
194positive regulation of amine transport (GO:0051954)2.41652886
195T cell differentiation (GO:0030217)2.41519417
196positive regulation of natural killer cell mediated immunity (GO:0002717)2.40702644
197tongue development (GO:0043586)2.40510582
198regulation of acyl-CoA biosynthetic process (GO:0050812)2.40495168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.37547708
2IGF1R_20145208_ChIP-Seq_DFB_Human4.02237651
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63108182
4EZH2_22144423_ChIP-Seq_EOC_Human3.31845373
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05584661
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.94041119
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68442817
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66988012
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52989886
10ZNF263_19887448_ChIP-Seq_K562_Human2.45512522
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34801653
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33916950
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33782533
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33782533
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33659737
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.32979361
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27277517
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23474259
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23290683
20RUNX_20019798_ChIP-Seq_JUKART_Human2.21877038
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.16970175
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14054843
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00971097
24* ER_23166858_ChIP-Seq_MCF-7_Human1.92257238
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.91210275
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89914500
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.89056117
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.88450452
29REST_21632747_ChIP-Seq_MESCs_Mouse1.82784297
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81990942
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81294881
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.80258772
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.79240460
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.75354045
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68631300
36* MYB_26560356_Chip-Seq_TH2_Human1.67087552
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66852644
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.65601045
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64270076
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.62067496
41GATA1_22025678_ChIP-Seq_K562_Human1.61832647
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60423910
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.59706750
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58135970
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57051306
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56909597
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.56465071
48KDM2B_26808549_Chip-Seq_K562_Human1.55914622
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55133782
50FUS_26573619_Chip-Seq_HEK293_Human1.54947035
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53964390
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52380626
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52175857
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.51881952
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51160825
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50522841
57ZNF274_21170338_ChIP-Seq_K562_Hela1.50004438
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49928065
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48755461
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48630993
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46505725
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46425443
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46373567
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44637044
65* GATA3_26560356_Chip-Seq_TH2_Human1.44123495
66* GATA3_27048872_Chip-Seq_THYMUS_Human1.43803791
67DROSHA_22980978_ChIP-Seq_HELA_Human1.42166953
68P300_19829295_ChIP-Seq_ESCs_Human1.42083974
69GBX2_23144817_ChIP-Seq_PC3_Human1.41625516
70CBP_20019798_ChIP-Seq_JUKART_Human1.40750529
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40750529
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.40005285
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36004280
74VDR_22108803_ChIP-Seq_LS180_Human1.35061993
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.33150530
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32160240
77VDR_24787735_ChIP-Seq_THP-1_Human1.28157742
78* MYB_26560356_Chip-Seq_TH1_Human1.27794499
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27524191
80* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27060019
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.25450018
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25239736
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23103186
84CLOCK_20551151_ChIP-Seq_293T_Human1.22782942
85* AHR_22903824_ChIP-Seq_MCF-7_Human1.22629169
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.20848352
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20045430
88SMAD4_21799915_ChIP-Seq_A2780_Human1.19688713
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.19078202
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18905621
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18455363
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17879126
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17037908
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16791585
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.16762894
96EWS_26573619_Chip-Seq_HEK293_Human1.16162767
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15443858
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14368567
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13492205
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12444249
101BCAT_22108803_ChIP-Seq_LS180_Human1.09773646
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08969264
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08592138
104CTCF_27219007_Chip-Seq_Bcells_Human1.07840172
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07803705
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07538479
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07486541
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06233132
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06161404
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.06051322
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.05943846
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05664679
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04303772
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04303772
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01729234
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.99722362
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99029514
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98873430
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98568603
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.98276737
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98246656
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96801647
123TAF15_26573619_Chip-Seq_HEK293_Human0.96766611
124RXR_22108803_ChIP-Seq_LS180_Human0.96365658
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.96104674
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96062754
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.95995574
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95658466
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95569093
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93905182
131AR_21572438_ChIP-Seq_LNCaP_Human0.93817345
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93780599
133* ARNT_22903824_ChIP-Seq_MCF-7_Human0.92390022
134* CDX2_22108803_ChIP-Seq_LS180_Human0.92345070
135WDR5_24793694_ChIP-Seq_LNCAP_Human0.91843315
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.91481127
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91063309
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91041248
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.90979918
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90821596
141TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90819683
142AR_25329375_ChIP-Seq_VCAP_Human0.90610872
143TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90420816
144TBL1_22424771_ChIP-Seq_293T_Human0.90177491
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89663938
146* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89180236
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89010396
148AR_19668381_ChIP-Seq_PC3_Human0.88543570
149* GATA3_26560356_Chip-Seq_TH1_Human0.87642573
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87438357
151GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87405080
152GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87147414
153ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86757106
154* KLF4_19829295_ChIP-Seq_ESCs_Human0.86249604
155SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86115126
156* RUNX2_22187159_ChIP-Seq_PCA_Human0.86075877
157* SOX2_20726797_ChIP-Seq_SW620_Human0.86020069
158TP53_18474530_ChIP-ChIP_U2OS_Human0.85825484
159* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85712971
160SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84732633
161OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84593020
162SOX2_19829295_ChIP-Seq_ESCs_Human0.83841498
163NANOG_19829295_ChIP-Seq_ESCs_Human0.83841498
164OCT1_27270436_Chip-Seq_PROSTATE_Human0.83221625
165* NANOG_20526341_ChIP-Seq_ESCs_Human0.83201477
166TCF4_22108803_ChIP-Seq_LS180_Human0.83074695
167RUNX1_27514584_Chip-Seq_MCF-7_Human0.82902194
168ELF5_23300383_ChIP-Seq_T47D_Human0.82641362
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.82426952
170* STAT3_23295773_ChIP-Seq_U87_Human0.81562203
171SPI1_23547873_ChIP-Seq_NB4_Human0.81346885
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80696368
173EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80332812
174CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80262175
175VDR_23849224_ChIP-Seq_CD4+_Human0.80137944
176RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80025687
177* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79385857
178SMAD3_21741376_ChIP-Seq_EPCs_Human0.79352162
179IRF8_27001747_Chip-Seq_BMDM_Mouse0.79164131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception4.46378170
2MP0002735_abnormal_chemical_nociception4.02094034
3MP0004859_abnormal_synaptic_plasticity3.92661271
4MP0004270_analgesia3.75688222
5MP0002736_abnormal_nociception_after3.58429220
6MP0003763_abnormal_thymus_physiology3.43855844
7MP0008004_abnormal_stomach_pH3.31683420
8MP0010234_abnormal_vibrissa_follicle3.26856849
9MP0003806_abnormal_nucleotide_metabolis3.04624751
10MP0002733_abnormal_thermal_nociception3.02160256
11MP0002822_catalepsy2.91814223
12MP0002734_abnormal_mechanical_nocicepti2.87896995
13MP0000465_gastrointestinal_hemorrhage2.74244771
14MP0000013_abnormal_adipose_tissue2.67888020
15MP0005410_abnormal_fertilization2.57341525
16MP0004858_abnormal_nervous_system2.55879549
17MP0003635_abnormal_synaptic_transmissio2.55739482
18MP0005671_abnormal_response_to2.54723736
19MP0001970_abnormal_pain_threshold2.49601848
20MP0003315_abnormal_perineum_morphology2.45467977
21MP0002909_abnormal_adrenal_gland2.44084270
22MP0001835_abnormal_antigen_presentation2.42315457
23MP0009780_abnormal_chondrocyte_physiolo2.28692025
24MP0003646_muscle_fatigue2.20442094
25MP0006276_abnormal_autonomic_nervous2.15995885
26MP0003724_increased_susceptibility_to2.11218214
27MP0002837_dystrophic_cardiac_calcinosis2.08941553
28MP0004381_abnormal_hair_follicle2.03753855
29MP0001800_abnormal_humoral_immune1.98662571
30MP0005167_abnormal_blood-brain_barrier1.97336824
31MP0002063_abnormal_learning/memory/cond1.96391756
32MP0006036_abnormal_mitochondrial_physio1.96373554
33MP0002160_abnormal_reproductive_system1.95389213
34MP0000751_myopathy1.89741445
35MP0002272_abnormal_nervous_system1.88173299
36MP0009745_abnormal_behavioral_response1.87521300
37MP0002009_preneoplasia1.87336114
38MP0004272_abnormal_basement_membrane1.80119911
39MP0002132_abnormal_respiratory_system1.75052269
40MP0003880_abnormal_central_pattern1.73087102
41MP0001986_abnormal_taste_sensitivity1.71053699
42MP0005000_abnormal_immune_tolerance1.70577824
43MP0003879_abnormal_hair_cell1.60201901
44MP0002420_abnormal_adaptive_immunity1.58744432
45MP0009785_altered_susceptibility_to1.58371476
46MP0002064_seizures1.57993232
47MP0003283_abnormal_digestive_organ1.57866786
48MP0002148_abnormal_hypersensitivity_rea1.56731898
49MP0001819_abnormal_immune_cell1.55832642
50MP0002723_abnormal_immune_serum1.54579956
51MP0005387_immune_system_phenotype1.54257861
52MP0001790_abnormal_immune_system1.54257861
53MP0009046_muscle_twitch1.53152261
54MP0005451_abnormal_body_composition1.50436994
55MP0002067_abnormal_sensory_capabilities1.49318495
56MP0004215_abnormal_myocardial_fiber1.45506149
57MP0002166_altered_tumor_susceptibility1.44867295
58MP0005623_abnormal_meninges_morphology1.41635506
59MP0002572_abnormal_emotion/affect_behav1.41457956
60MP0002452_abnormal_antigen_presenting1.41388875
61MP0000703_abnormal_thymus_morphology1.36954552
62MP0004084_abnormal_cardiac_muscle1.36327130
63MP0002184_abnormal_innervation1.35717374
64MP0004036_abnormal_muscle_relaxation1.34644266
65MP0010368_abnormal_lymphatic_system1.33410987
66MP0004130_abnormal_muscle_cell1.33156677
67MP0001299_abnormal_eye_distance/1.33134124
68MP0005389_reproductive_system_phenotype1.32947644
69MP0005360_urolithiasis1.31985161
70MP0003329_amyloid_beta_deposits1.30867424
71MP0000685_abnormal_immune_system1.29962990
72MP0004811_abnormal_neuron_physiology1.29725685
73MP0003705_abnormal_hypodermis_morpholog1.28892705
74MP0004145_abnormal_muscle_electrophysio1.26023332
75MP0002398_abnormal_bone_marrow1.24026998
76MP0008961_abnormal_basal_metabolism1.23634790
77MP0001919_abnormal_reproductive_system1.22122309
78MP0005330_cardiomyopathy1.21001594
79MP0000716_abnormal_immune_system1.20712168
80MP0001501_abnormal_sleep_pattern1.20706470
81MP0005275_abnormal_skin_tensile1.19393696
82MP0002102_abnormal_ear_morphology1.18773260
83MP0003436_decreased_susceptibility_to1.18329274
84MP0000747_muscle_weakness1.18263864
85MP0005166_decreased_susceptibility_to1.18034994
86MP0001984_abnormal_olfaction1.16945927
87MP0004085_abnormal_heartbeat1.16716837
88MP0003787_abnormal_imprinting1.16638250
89MP0005025_abnormal_response_to1.16393460
90MP0002877_abnormal_melanocyte_morpholog1.16345586
91MP0001879_abnormal_lymphatic_vessel1.15774131
92MP0004484_altered_response_of1.14152802
93MP0003828_pulmonary_edema1.13874704
94MP0006072_abnormal_retinal_apoptosis1.12290213
95MP0010155_abnormal_intestine_physiology1.12010077
96MP0005075_abnormal_melanosome_morpholog1.11015147
97MP0002127_abnormal_cardiovascular_syste1.09373576
98MP0000534_abnormal_ureter_morphology1.07484705
99MP0002419_abnormal_innate_immunity1.06332822
100MP0002722_abnormal_immune_system1.05648247
101MP0005620_abnormal_muscle_contractility1.03101966
102MP0010386_abnormal_urinary_bladder1.01623789
103MP0001905_abnormal_dopamine_level1.00982068
104MP0001929_abnormal_gametogenesis1.00849467
105MP0001348_abnormal_lacrimal_gland1.00815524
106MP0001440_abnormal_grooming_behavior1.00448803
107MP0000689_abnormal_spleen_morphology0.99762583
108MP0002972_abnormal_cardiac_muscle0.99635054
109MP0001873_stomach_inflammation0.99215323
110MP0001486_abnormal_startle_reflex0.99202284
111MP0004510_myositis0.99003289
112MP0002638_abnormal_pupillary_reflex0.98695714
113MP0000749_muscle_degeneration0.97807453
114MP0009333_abnormal_splenocyte_physiolog0.96757372
115MP0001664_abnormal_digestion0.96725901
116MP0003698_abnormal_male_reproductive0.96239078
117MP0001845_abnormal_inflammatory_respons0.95667832
118MP0002138_abnormal_hepatobiliary_system0.94634682
119MP0000003_abnormal_adipose_tissue0.93763165
120MP0002405_respiratory_system_inflammati0.93127540
121MP0000955_abnormal_spinal_cord0.92794689
122MP0003633_abnormal_nervous_system0.92449971
123MP0008569_lethality_at_weaning0.91699851
124MP0002277_abnormal_respiratory_mucosa0.89595594
125MP0004233_abnormal_muscle_weight0.89358889
126MP0000343_altered_response_to0.88683935
127MP0005187_abnormal_penis_morphology0.88423531
128MP0003075_altered_response_to0.87824319
129MP0001529_abnormal_vocalization0.86644865
130MP0003045_fibrosis0.86585728
131MP0002693_abnormal_pancreas_physiology0.85473698
132MP0005253_abnormal_eye_physiology0.85167999
133MP0002557_abnormal_social/conspecific_i0.84732212
134MP0004087_abnormal_muscle_fiber0.84098806
135MP0009697_abnormal_copulation0.83111410
136MP0004043_abnormal_pH_regulation0.82703530
137MP0005058_abnormal_lysosome_morphology0.82441620
138MP0003866_abnormal_defecation0.82011232
139MP0003183_abnormal_peptide_metabolism0.81049657
140MP0003656_abnormal_erythrocyte_physiolo0.80894700
141MP0001270_distended_abdomen0.80860067
142MP0003300_gastrointestinal_ulcer0.80302322
143MP0004924_abnormal_behavior0.79771914
144MP0005386_behavior/neurological_phenoty0.79771914
145MP0005266_abnormal_metabolism0.79360624
146MP0002751_abnormal_autonomic_nervous0.78432532
147MP0005647_abnormal_sex_gland0.77593763
148MP0000759_abnormal_skeletal_muscle0.77298157
149MP0002066_abnormal_motor_capabilities/c0.77029532
150MP0002429_abnormal_blood_cell0.76865926
151MP0002332_abnormal_exercise_endurance0.76810377
152MP0002882_abnormal_neuron_morphology0.76205535
153MP0002796_impaired_skin_barrier0.76169764
154MP0005369_muscle_phenotype0.74648114
155MP0002896_abnormal_bone_mineralization0.74552323
156MP0002876_abnormal_thyroid_physiology0.74006870
157MP0005499_abnormal_olfactory_system0.73600657
158MP0005394_taste/olfaction_phenotype0.73600657
159MP0000230_abnormal_systemic_arterial0.73450052
160MP0006138_congestive_heart_failure0.73191423
161MP0008874_decreased_physiological_sensi0.72704335
162MP0005385_cardiovascular_system_phenoty0.69765921
163MP0001544_abnormal_cardiovascular_syste0.69765921
164MP0010771_integument_phenotype0.68512983
165MP0001188_hyperpigmentation0.67831105
166MP0005595_abnormal_vascular_smooth0.67801435
167MP0002269_muscular_atrophy0.65967769
168MP0001756_abnormal_urination0.64839339
169MP0003279_aneurysm0.64313130
170MP0008775_abnormal_heart_ventricle0.63412006
171MP0001958_emphysema0.62480575
172MP0005165_increased_susceptibility_to0.62395703
173MP0000750_abnormal_muscle_regeneration0.61215800
174MP0002106_abnormal_muscle_physiology0.60780426
175MP0005535_abnormal_body_temperature0.60474401

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.87142749
2Eosinophilia (HP:0001880)4.55769586
3Reduced antithrombin III activity (HP:0001976)4.42525100
4Abnormality of the columella (HP:0009929)4.35890997
5Abnormality of eosinophils (HP:0001879)4.05701498
6Focal motor seizures (HP:0011153)4.03016461
7Muscle fiber inclusion bodies (HP:0100299)3.85758271
8Rimmed vacuoles (HP:0003805)3.83477412
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.80261850
10Granulocytopenia (HP:0001913)3.74655688
11Clumsiness (HP:0002312)3.67078295
12Muscle hypertrophy of the lower extremities (HP:0008968)3.57366262
13Focal seizures (HP:0007359)3.51436761
14Visual hallucinations (HP:0002367)3.47977729
15Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.47926648
16Ulnar claw (HP:0001178)3.45113236
17EMG: myopathic abnormalities (HP:0003458)3.43447904
18Action tremor (HP:0002345)3.38084354
19Calf muscle hypertrophy (HP:0008981)3.36144389
20Abnormality of T cell number (HP:0011839)3.31163603
21Pheochromocytoma (HP:0002666)3.29074947
22Hypercortisolism (HP:0001578)3.25676349
23Stomatitis (HP:0010280)3.22044727
24T lymphocytopenia (HP:0005403)3.18366932
25Impaired pain sensation (HP:0007328)3.07557330
26Abnormality of pain sensation (HP:0010832)3.07557330
27Abnormality of the frontal sinuses (HP:0002687)3.03757049
28Abnormality of the calf musculature (HP:0001430)3.03108857
29Ankle clonus (HP:0011448)3.01165807
30IgG deficiency (HP:0004315)2.96229109
31Atonic seizures (HP:0010819)2.96095788
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.96066317
33Ventricular fibrillation (HP:0001663)2.93020500
34Neck muscle weakness (HP:0000467)2.88128955
35Abnormality of the shoulder girdle musculature (HP:0001435)2.87980456
36Dysautonomia (HP:0002459)2.87297236
37Annular pancreas (HP:0001734)2.86176015
38Neuroendocrine neoplasm (HP:0100634)2.86091688
39Myotonia (HP:0002486)2.85607174
40Myoglobinuria (HP:0002913)2.83830268
41Papilledema (HP:0001085)2.81348456
42Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.79976519
43Colitis (HP:0002583)2.77071435
44Rhabdomyolysis (HP:0003201)2.76139539
45Nemaline bodies (HP:0003798)2.73723820
46Scapular winging (HP:0003691)2.71899700
47Postural instability (HP:0002172)2.71313510
48Thyroiditis (HP:0100646)2.70598406
49Termporal pattern (HP:0011008)2.69890872
50Insidious onset (HP:0003587)2.69890872
51Leukocytosis (HP:0001974)2.69038065
52Distal arthrogryposis (HP:0005684)2.68808526
53Inflammation of the large intestine (HP:0002037)2.64103831
54Autoimmune hemolytic anemia (HP:0001890)2.59930123
55Absence seizures (HP:0002121)2.56611601
56Frequent falls (HP:0002359)2.55887920
57Sudden death (HP:0001699)2.52659729
58Abnormal ciliary motility (HP:0012262)2.50674281
59Neoplasm of the peripheral nervous system (HP:0100007)2.48930080
60Abnormal respiratory motile cilium physiology (HP:0012261)2.47891275
61Depression (HP:0000716)2.46738018
62Hyporeflexia of lower limbs (HP:0002600)2.46199383
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42738488
64Resting tremor (HP:0002322)2.40414165
65Abnormality of T cells (HP:0002843)2.39980048
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39804361
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39804361
68Difficulty climbing stairs (HP:0003551)2.39237344
69Type II lissencephaly (HP:0007260)2.37534236
70Rapidly progressive (HP:0003678)2.35789186
71Severe combined immunodeficiency (HP:0004430)2.34013897
72Gastrointestinal inflammation (HP:0004386)2.32409839
73Hypoplasia of the uterus (HP:0000013)2.31157406
74Hypothermia (HP:0002045)2.31013801
75Segmental peripheral demyelination/remyelination (HP:0003481)2.30158834
76Hammertoe (HP:0001765)2.27337805
77Bundle branch block (HP:0011710)2.26990175
78Gonadal dysgenesis (HP:0000133)2.26832297
79Absent/shortened dynein arms (HP:0200106)2.26766805
80Dynein arm defect of respiratory motile cilia (HP:0012255)2.26766805
81Chronic sinusitis (HP:0011109)2.26638191
82Dialeptic seizures (HP:0011146)2.22671456
83Protruding tongue (HP:0010808)2.22086173
84Cerebellar dysplasia (HP:0007033)2.21392411
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20728133
86Sensory axonal neuropathy (HP:0003390)2.20525219
87Generalized tonic-clonic seizures (HP:0002069)2.20022170
88Muscular dystrophy (HP:0003560)2.18938211
89Supranuclear gaze palsy (HP:0000605)2.18177073
90Myopathic facies (HP:0002058)2.17479735
91Proximal amyotrophy (HP:0007126)2.16838366
92Hypoventilation (HP:0002791)2.16488038
93Inability to walk (HP:0002540)2.15289458
94Difficulty running (HP:0009046)2.14132177
95Abnormal respiratory motile cilium morphology (HP:0005938)2.13916420
96Abnormal respiratory epithelium morphology (HP:0012253)2.13916420
97Sex reversal (HP:0012245)2.13345218
98Abnormal sex determination (HP:0012244)2.13345218
99Increased variability in muscle fiber diameter (HP:0003557)2.13220260
100Anxiety (HP:0000739)2.13074107
101Torticollis (HP:0000473)2.11561331
102Muscle fiber splitting (HP:0003555)2.11215994
103Bulbar palsy (HP:0001283)2.10769913
104Abnormal delayed hypersensitivity skin test (HP:0002963)2.08933697
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08546466
106Distal upper limb amyotrophy (HP:0007149)2.07480016
107Upper limb amyotrophy (HP:0009129)2.07480016
108Failure to thrive in infancy (HP:0001531)2.06517436
109Polyneuropathy (HP:0001271)2.06001666
110Prolonged QT interval (HP:0001657)2.05632095
111Febrile seizures (HP:0002373)2.05181661
112Thoracic kyphosis (HP:0002942)2.04770898
113Amblyopia (HP:0000646)2.03026414
114Foot dorsiflexor weakness (HP:0009027)2.01561041
115Bronchiectasis (HP:0002110)2.01454849
116Aplasia/hypoplasia of the uterus (HP:0008684)2.00971595
117Progressive cerebellar ataxia (HP:0002073)2.00530657
118Abnormality of the vocal cords (HP:0008777)2.00390302
119Urinary urgency (HP:0000012)1.99986919
120Deep palmar crease (HP:0006191)1.99162112
121Areflexia of lower limbs (HP:0002522)1.98819180
122Megalencephaly (HP:0001355)1.98607323
123Growth hormone excess (HP:0000845)1.98391170
124Cerebral aneurysm (HP:0004944)1.97028676
125Recurrent sinusitis (HP:0011108)1.96529960
126Abnormality of calcium-phosphate metabolism (HP:0100530)1.96330859
127Limb dystonia (HP:0002451)1.95202197
128Abnormality of the lower motor neuron (HP:0002366)1.94694133
129Adrenal overactivity (HP:0002717)1.93972122
130Rhinitis (HP:0012384)1.93848143
131Hypoproteinemia (HP:0003075)1.93745475
132Abnormal protein glycosylation (HP:0012346)1.92466666
133Abnormal glycosylation (HP:0012345)1.92466666
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92466666
135Abnormal protein N-linked glycosylation (HP:0012347)1.92466666
136Retrobulbar optic neuritis (HP:0100654)1.91610108
137Optic neuritis (HP:0100653)1.91610108
138B lymphocytopenia (HP:0010976)1.91068850
139Lower limb asymmetry (HP:0100559)1.91040218
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90372889
141Buphthalmos (HP:0000557)1.90204656
142Cerebral hemorrhage (HP:0001342)1.89122195
143Palpitations (HP:0001962)1.88719728
144Facial shape deformation (HP:0011334)1.88256619
145Potter facies (HP:0002009)1.88256619
146Male pseudohermaphroditism (HP:0000037)1.88233963
147Vasculitis (HP:0002633)1.88227082
148Recurrent bronchitis (HP:0002837)1.87055393
149Exercise-induced myalgia (HP:0003738)1.86873198
150Postural tremor (HP:0002174)1.86134474
151Weak cry (HP:0001612)1.85939653
152Abnormality of the intrinsic pathway (HP:0010989)1.85802089
153Increased IgM level (HP:0003496)1.85419253
154Abnormality of skeletal muscle fiber size (HP:0012084)1.85125963
155Distal sensory impairment (HP:0002936)1.84874555
156Truncal ataxia (HP:0002078)1.84736912
157Abnormality of the foot musculature (HP:0001436)1.84070643
158Absent speech (HP:0001344)1.83994056
159Vertebral arch anomaly (HP:0008438)1.83852819
160Unsteady gait (HP:0002317)1.83741126
161Abnormal EKG (HP:0003115)1.83440089
162Facial diplegia (HP:0001349)1.82958777
163Bradycardia (HP:0001662)1.82936172
164Steppage gait (HP:0003376)1.81109026
165Poor eye contact (HP:0000817)1.80772521
166Thoracolumbar scoliosis (HP:0002944)1.79606338
167Shoulder girdle muscle weakness (HP:0003547)1.79018728
168Hand muscle atrophy (HP:0009130)1.78537483
169Hematochezia (HP:0002573)1.78462066
170Exercise-induced muscle cramps (HP:0003710)1.77641508
171Ankyloglossia (HP:0010296)1.77029770
172Abnormal social behavior (HP:0012433)1.76702943
173Impaired social interactions (HP:0000735)1.76702943
174Increased connective tissue (HP:0009025)1.76656027
175Menstrual irregularities (HP:0000858)1.76628623
176Abnormal autonomic nervous system physiology (HP:0012332)1.73296760
177Focal dystonia (HP:0004373)1.72368618
178Neoplasm of the heart (HP:0100544)1.72145986
179Onion bulb formation (HP:0003383)1.71918867
180Bronchomalacia (HP:0002780)1.69999740
181Craniofacial dystonia (HP:0012179)1.69887610
182Impaired vibration sensation in the lower limbs (HP:0002166)1.68499029
183Achilles tendon contracture (HP:0001771)1.68470041
184Atrioventricular block (HP:0001678)1.68159540
185Hyperparathyroidism (HP:0000843)1.67794086
186Testicular atrophy (HP:0000029)1.65749436
187Retinal dysplasia (HP:0007973)1.65005259
188Long toe (HP:0010511)1.65002001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.71486384
2MAP3K94.11775551
3KSR23.77657870
4NTRK33.49995945
5NTRK13.23531816
6TLK13.05304405
7MAP3K22.97847047
8EPHA42.74944975
9PRKD32.66576177
10ARAF2.49062498
11MINK12.37478712
12TXK2.32024366
13RIPK42.23723363
14TRIB32.02436027
15FER2.00343988
16TIE11.92645201
17CAMKK21.83627949
18LMTK21.77410293
19MAP3K121.75930493
20LATS11.73098273
21EIF2AK31.71098743
22LATS21.66951691
23RET1.63780497
24BMPR21.63213326
25SCYL21.61062141
26GRK51.59922872
27CAMKK11.59673168
28PAK61.55293178
29NEK11.53981276
30ZAK1.53922720
31MAP3K11.53206944
32MYLK1.47328394
33STK38L1.46687458
34DAPK21.46345460
35DDR21.46022048
36NLK1.41201880
37PHKG11.35912544
38PHKG21.35912544
39MAP2K11.34368216
40KSR11.33502909
41FRK1.33240150
42MAP3K41.30959334
43CSNK1A1L1.30409730
44MAP2K41.28820921
45BTK1.27777996
46GRK61.27744596
47MST41.27178838
48RPS6KA51.26534099
49PDK31.24384301
50PDK41.24384301
51PIK3CA1.23625261
52PTK2B1.22105927
53PRKCQ1.21178912
54LIMK11.21097774
55RIPK11.19464472
56PDGFRA1.17015076
57CSNK1G31.16898692
58NEK21.14152109
59MAPKAPK31.12760471
60MAPK121.11642930
61ERBB31.10509234
62TAOK11.10221026
63MAP4K11.07436452
64PDK21.04063306
65PINK11.03734040
66KDR1.00550532
67BRAF0.99531120
68PTK20.98532642
69RPS6KA40.98501370
70WNK40.97440119
71PAK30.96482813
72CDK30.96349585
73* CDK50.95959873
74IKBKE0.95442624
75MAP2K20.94476563
76CSNK1G20.94212459
77TRPM70.93892713
78CSNK1G10.93479576
79TESK10.91283569
80SGK20.91042270
81SIK30.90056907
82PDPK10.85852002
83TAOK30.84184039
84MAP3K130.83004460
85STK380.81873010
86ITK0.81710872
87MAP3K140.80858345
88MAPK130.80182189
89RAF10.79855485
90MAP3K50.78870108
91MAP3K110.78359214
92DYRK30.77755972
93MATK0.77581898
94RPS6KB10.77502798
95ZAP700.75189517
96PKN20.72371827
97BMPR1B0.71880231
98JAK10.71543342
99PDK10.69300092
100SYK0.68603740
101HCK0.63948130
102ADRBK20.63770760
103DAPK10.63447125
104TRIM280.63309827
105UHMK10.62723671
106IKBKB0.62307771
107TTN0.61550557
108PRKCH0.61291018
109IRAK20.58123116
110PRKCE0.56997140
111PRKCG0.56192644
112PRKG20.55724672
113CCNB10.54962948
114* CDK140.54586389
115PIK3CG0.53689285
116LCK0.53380207
117RPS6KA20.52743736
118EPHB20.52633973
119TEC0.52543850
120MOS0.51858055
121DMPK0.51753882
122EGFR0.51042281
123WNK10.50955263
124TYRO30.50390085
125MAP2K70.49284223
126MUSK0.49056105
127PTK60.48334822
128ALK0.47890327
129SGK2230.45846926
130SGK4940.45846926
131CAMK2D0.45578471
132CAMK2A0.44899527
133CDK180.44811263
134TNK20.44639779
135BLK0.44161682
136PLK20.43983619
137CSK0.43432489
138LRRK20.42292728
139CDK150.42020643
140HIPK20.41471150
141MAPK150.40984558
142SGK30.40246133
143MAP3K100.40095628
144STK110.39378612
145NEK60.38731047
146OXSR10.38365856
147CLK10.37952780
148FES0.37838636
149BCR0.37510521
150JAK20.36884280
151LYN0.36524245
152TBK10.36205898
153PRKD10.35947721
154FGFR30.35370550
155MARK10.35015468
156MAP4K20.34508673
157GRK10.34260186
158TGFBR20.34013340
159PRKCZ0.33864078
160KIT0.33094953
161BRSK10.32653649
162TNIK0.32617452
163CDC42BPA0.31538715
164CDK11A0.31488947
165CSNK1D0.31310152
166MAP3K30.30757441
167EPHA30.30531286
168MAPK100.30276610
169PRKG10.29229473
170IRAK10.28950764
171FGR0.28395552
172MARK20.28290098
173SIK20.23101409
174CAMK40.21615626

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.34802845
2Primary immunodeficiency_Homo sapiens_hsa053402.84514936
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.66985696
4T cell receptor signaling pathway_Homo sapiens_hsa046602.60783133
5Synaptic vesicle cycle_Homo sapiens_hsa047212.57275114
6Allograft rejection_Homo sapiens_hsa053302.46189276
7Graft-versus-host disease_Homo sapiens_hsa053322.33916554
8Long-term potentiation_Homo sapiens_hsa047202.24835780
9Autoimmune thyroid disease_Homo sapiens_hsa053202.23095071
10Olfactory transduction_Homo sapiens_hsa047402.19438593
11Type I diabetes mellitus_Homo sapiens_hsa049402.12087632
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04754251
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.03655982
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00424658
15Insulin secretion_Homo sapiens_hsa049111.99114880
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.91806052
17Amphetamine addiction_Homo sapiens_hsa050311.91291235
18Systemic lupus erythematosus_Homo sapiens_hsa053221.90996496
19Dopaminergic synapse_Homo sapiens_hsa047281.90378546
20Regulation of autophagy_Homo sapiens_hsa041401.87126552
21Circadian entrainment_Homo sapiens_hsa047131.82371081
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74271168
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.73187493
24Asthma_Homo sapiens_hsa053101.73020940
25B cell receptor signaling pathway_Homo sapiens_hsa046621.69121918
26GABAergic synapse_Homo sapiens_hsa047271.69023441
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68388917
28Cholinergic synapse_Homo sapiens_hsa047251.60090956
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53593029
30Apoptosis_Homo sapiens_hsa042101.53143251
31Gastric acid secretion_Homo sapiens_hsa049711.52844876
32Salivary secretion_Homo sapiens_hsa049701.52090366
33Morphine addiction_Homo sapiens_hsa050321.51999491
34Cocaine addiction_Homo sapiens_hsa050301.51962812
35Taste transduction_Homo sapiens_hsa047421.51861351
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50454556
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49948696
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.49779264
39Gap junction_Homo sapiens_hsa045401.49159139
40Phagosome_Homo sapiens_hsa041451.46709899
41Renin secretion_Homo sapiens_hsa049241.45505704
42Phototransduction_Homo sapiens_hsa047441.44591520
43Dorso-ventral axis formation_Homo sapiens_hsa043201.42263537
44GnRH signaling pathway_Homo sapiens_hsa049121.41856310
45Glutamatergic synapse_Homo sapiens_hsa047241.40981903
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39804553
47Oxytocin signaling pathway_Homo sapiens_hsa049211.39413200
48Legionellosis_Homo sapiens_hsa051341.37600166
49Thyroid cancer_Homo sapiens_hsa052161.37297333
50Glioma_Homo sapiens_hsa052141.36000128
51Estrogen signaling pathway_Homo sapiens_hsa049151.35798891
52Viral myocarditis_Homo sapiens_hsa054161.31164589
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30279237
54Nicotine addiction_Homo sapiens_hsa050331.29278135
55Long-term depression_Homo sapiens_hsa047301.27333932
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24960519
57Vibrio cholerae infection_Homo sapiens_hsa051101.21579342
58VEGF signaling pathway_Homo sapiens_hsa043701.21556235
59Collecting duct acid secretion_Homo sapiens_hsa049661.20606153
60Measles_Homo sapiens_hsa051621.19476750
61Butanoate metabolism_Homo sapiens_hsa006501.18754145
62Hematopoietic cell lineage_Homo sapiens_hsa046401.18565081
63Melanogenesis_Homo sapiens_hsa049161.18169969
64Calcium signaling pathway_Homo sapiens_hsa040201.17286636
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.15338062
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14694032
67Serotonergic synapse_Homo sapiens_hsa047261.10969246
68Cardiac muscle contraction_Homo sapiens_hsa042601.09449878
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08479270
70Oocyte meiosis_Homo sapiens_hsa041141.08196282
71Osteoclast differentiation_Homo sapiens_hsa043801.06842006
72Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05166941
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04834811
74Rheumatoid arthritis_Homo sapiens_hsa053231.02744227
75cAMP signaling pathway_Homo sapiens_hsa040241.02462889
76Neurotrophin signaling pathway_Homo sapiens_hsa047221.00843633
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99978064
78Dilated cardiomyopathy_Homo sapiens_hsa054140.99673938
79Herpes simplex infection_Homo sapiens_hsa051680.99255959
80Tuberculosis_Homo sapiens_hsa051520.98096182
81Type II diabetes mellitus_Homo sapiens_hsa049300.97255473
82Thyroid hormone synthesis_Homo sapiens_hsa049180.96435807
83mTOR signaling pathway_Homo sapiens_hsa041500.94324618
84Antigen processing and presentation_Homo sapiens_hsa046120.93900832
85Rap1 signaling pathway_Homo sapiens_hsa040150.93423555
86Pancreatic secretion_Homo sapiens_hsa049720.93197876
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92841721
88FoxO signaling pathway_Homo sapiens_hsa040680.92379097
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.90011884
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.90008104
91Insulin signaling pathway_Homo sapiens_hsa049100.89916064
92Glucagon signaling pathway_Homo sapiens_hsa049220.89079279
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87478961
94Endometrial cancer_Homo sapiens_hsa052130.84382718
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84031188
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80205247
97ErbB signaling pathway_Homo sapiens_hsa040120.79979946
98Propanoate metabolism_Homo sapiens_hsa006400.79507604
99Endocytosis_Homo sapiens_hsa041440.79160122
100Tight junction_Homo sapiens_hsa045300.78006082
101Leishmaniasis_Homo sapiens_hsa051400.77228287
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76392071
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75663795
104Bladder cancer_Homo sapiens_hsa052190.75640253
105Renal cell carcinoma_Homo sapiens_hsa052110.75423349
106RNA degradation_Homo sapiens_hsa030180.74828730
107Nitrogen metabolism_Homo sapiens_hsa009100.74745052
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74261035
109Focal adhesion_Homo sapiens_hsa045100.74162941
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.73753554
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72575091
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71165156
113Hepatitis B_Homo sapiens_hsa051610.70772651
114Choline metabolism in cancer_Homo sapiens_hsa052310.69536991
115Melanoma_Homo sapiens_hsa052180.68860168
116TNF signaling pathway_Homo sapiens_hsa046680.68639432
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68108656
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67417192
119Toxoplasmosis_Homo sapiens_hsa051450.66491564
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.66489151
121Prolactin signaling pathway_Homo sapiens_hsa049170.66275612
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65887643
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65816327
124Axon guidance_Homo sapiens_hsa043600.64835882
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64712904
126Non-small cell lung cancer_Homo sapiens_hsa052230.63803154
127Ras signaling pathway_Homo sapiens_hsa040140.63688589
128MAPK signaling pathway_Homo sapiens_hsa040100.62525627
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62435365
130Prion diseases_Homo sapiens_hsa050200.62240406
131Chemokine signaling pathway_Homo sapiens_hsa040620.61986277
132Adherens junction_Homo sapiens_hsa045200.61569238
133Malaria_Homo sapiens_hsa051440.60534936
134Proteoglycans in cancer_Homo sapiens_hsa052050.59825383
135Influenza A_Homo sapiens_hsa051640.59660210
136Circadian rhythm_Homo sapiens_hsa047100.59365287
137Insulin resistance_Homo sapiens_hsa049310.58159351
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58133743
139Hedgehog signaling pathway_Homo sapiens_hsa043400.58072996
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56575337
141Amoebiasis_Homo sapiens_hsa051460.55303891
142Acute myeloid leukemia_Homo sapiens_hsa052210.54246584
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53408300
144Hippo signaling pathway_Homo sapiens_hsa043900.52715308
145Basal transcription factors_Homo sapiens_hsa030220.51045825
146Chemical carcinogenesis_Homo sapiens_hsa052040.50803218
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.49216095
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48636444
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47779106
150Alcoholism_Homo sapiens_hsa050340.47454380
151HIF-1 signaling pathway_Homo sapiens_hsa040660.46777253
152Salmonella infection_Homo sapiens_hsa051320.45037276
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44126496
154SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42484516
155Arginine biosynthesis_Homo sapiens_hsa002200.42347061
156Staphylococcus aureus infection_Homo sapiens_hsa051500.42093103
157Inositol phosphate metabolism_Homo sapiens_hsa005620.42025077
158Platelet activation_Homo sapiens_hsa046110.41129183
159Pertussis_Homo sapiens_hsa051330.39581920
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38811683

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