PPP1R1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic transmission, dopaminergic (GO:0001963)6.66568316
2prepulse inhibition (GO:0060134)6.41853234
3regulation of synapse structural plasticity (GO:0051823)6.35714187
4adenosine receptor signaling pathway (GO:0001973)5.85730525
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82735211
6striatum development (GO:0021756)5.59099170
7synaptic vesicle maturation (GO:0016188)5.52095599
8locomotory exploration behavior (GO:0035641)5.50208211
9adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.44319231
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.17819798
11sodium ion export (GO:0071436)5.15992159
12regulation of long-term neuronal synaptic plasticity (GO:0048169)5.13010642
13auditory behavior (GO:0031223)5.09351343
14vocalization behavior (GO:0071625)4.98535519
15dopamine receptor signaling pathway (GO:0007212)4.85454442
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.83502664
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80989262
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.79983390
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78163282
20positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.75830162
21positive regulation of synaptic transmission, GABAergic (GO:0032230)4.74587652
22regulation of neuronal synaptic plasticity (GO:0048168)4.68942656
23neurotransmitter-gated ion channel clustering (GO:0072578)4.66660563
24negative regulation of cytosolic calcium ion concentration (GO:0051481)4.64754875
25regulation of glutamate receptor signaling pathway (GO:1900449)4.63528230
26behavioral response to cocaine (GO:0048148)4.56271234
27regulation of dendritic spine morphogenesis (GO:0061001)4.50893290
28positive regulation of neurotransmitter transport (GO:0051590)4.46314043
29substrate-independent telencephalic tangential migration (GO:0021826)4.43842881
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.43842881
31regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.43074097
32regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.43074097
33neuromuscular process controlling balance (GO:0050885)4.38738018
34response to auditory stimulus (GO:0010996)4.33057165
35* response to amphetamine (GO:0001975)4.32094544
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.31222543
37cAMP catabolic process (GO:0006198)4.22740379
38regulation of glutamate secretion (GO:0014048)4.21168252
39maintenance of gastrointestinal epithelium (GO:0030277)4.16918566
40dendritic spine morphogenesis (GO:0060997)4.16254623
41synaptic vesicle exocytosis (GO:0016079)4.10149659
42phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.08653688
43synaptic vesicle docking involved in exocytosis (GO:0016081)4.06107732
44neuron-neuron synaptic transmission (GO:0007270)4.03890830
45ionotropic glutamate receptor signaling pathway (GO:0035235)4.02130177
46regulation of cholesterol homeostasis (GO:2000188)3.99366460
47neurotransmitter secretion (GO:0007269)3.99023917
48cerebellar granule cell differentiation (GO:0021707)3.96827798
49regulation of neurotransmitter uptake (GO:0051580)3.95802425
50positive regulation of synapse maturation (GO:0090129)3.95183776
51exploration behavior (GO:0035640)3.94196946
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94034328
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.93537979
54regulation of synaptic vesicle exocytosis (GO:2000300)3.93074171
55neuronal ion channel clustering (GO:0045161)3.92938591
56peristalsis (GO:0030432)3.92234587
57positive regulation of neurotransmitter secretion (GO:0001956)3.91086141
58long-term memory (GO:0007616)3.88893097
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.86038226
60positive regulation of membrane potential (GO:0045838)3.84907698
61transmission of nerve impulse (GO:0019226)3.84106107
62neuronal action potential propagation (GO:0019227)3.78804368
63protein localization to synapse (GO:0035418)3.77186748
64cyclic nucleotide catabolic process (GO:0009214)3.71915529
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71708814
66gamma-aminobutyric acid transport (GO:0015812)3.70163119
67synaptic transmission, glutamatergic (GO:0035249)3.69597956
68L-amino acid import (GO:0043092)3.68257279
69regulation of synaptic plasticity (GO:0048167)3.67589028
70layer formation in cerebral cortex (GO:0021819)3.66844002
71mechanosensory behavior (GO:0007638)3.64903848
72behavioral defense response (GO:0002209)3.60835550
73behavioral fear response (GO:0001662)3.60835550
74cytoskeletal anchoring at plasma membrane (GO:0007016)3.60786219
75membrane hyperpolarization (GO:0060081)3.60231889
76cAMP metabolic process (GO:0046058)3.59046484
77regulation of postsynaptic membrane potential (GO:0060078)3.58771082
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.58769396
79drinking behavior (GO:0042756)3.58352979
80glycine transport (GO:0015816)3.58039933
81regulation of ARF protein signal transduction (GO:0032012)3.57417047
82regulation of norepinephrine secretion (GO:0014061)3.53486399
83proline metabolic process (GO:0006560)3.52172768
84regulation of voltage-gated calcium channel activity (GO:1901385)3.51256699
85regulation of synaptic vesicle transport (GO:1902803)3.50654500
86negative regulation of dendrite development (GO:2000171)3.49414012
87neurotransmitter transport (GO:0006836)3.48471222
88activation of protein kinase A activity (GO:0034199)3.47408527
89long-term synaptic potentiation (GO:0060291)3.47224443
90response to histamine (GO:0034776)3.44228495
91axon ensheathment in central nervous system (GO:0032291)3.42093831
92central nervous system myelination (GO:0022010)3.42093831
93potassium ion homeostasis (GO:0055075)3.39472659
94regulation of dendritic spine development (GO:0060998)3.38493766
95mating behavior (GO:0007617)3.38035500
96glutamate receptor signaling pathway (GO:0007215)3.33369487
97cellular sodium ion homeostasis (GO:0006883)3.31860306
98negative regulation of amino acid transport (GO:0051956)3.30794921
99synaptic vesicle endocytosis (GO:0048488)3.29866159
100* visual learning (GO:0008542)3.29741133
101regulation of synaptic transmission, GABAergic (GO:0032228)3.29153444
102glutamate secretion (GO:0014047)3.25709284
103regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25498532
104cAMP biosynthetic process (GO:0006171)3.25413661
105epithelial structure maintenance (GO:0010669)3.24910887
106cGMP metabolic process (GO:0046068)3.22061199
107amino acid import (GO:0043090)3.21298699
108regulation of synapse maturation (GO:0090128)3.20924197
109positive regulation of synaptic transmission (GO:0050806)3.18495808
110regulation of synaptic transmission, dopaminergic (GO:0032225)3.18365355
111fear response (GO:0042596)3.17183436
112regulation of bile acid biosynthetic process (GO:0070857)3.16144264
113potassium ion import (GO:0010107)3.15969333
114neuromuscular process (GO:0050905)3.15563144
115regulation of protein kinase A signaling (GO:0010738)3.14591723
116* regulation of female receptivity (GO:0045924)3.11466614
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.11411062
118negative regulation of dendrite morphogenesis (GO:0050774)3.11174917
119cellular potassium ion homeostasis (GO:0030007)3.10832675
120* visual behavior (GO:0007632)3.09386826
121myelin maintenance (GO:0043217)3.08866207
122membrane depolarization (GO:0051899)3.07883728
123regulation of neurotransmitter levels (GO:0001505)3.06718127
124dendritic spine organization (GO:0097061)3.06485407
125positive regulation of dendritic spine development (GO:0060999)3.04989372
126lung epithelium development (GO:0060428)3.01197133
127cell communication by electrical coupling (GO:0010644)3.00173324
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98003164
129long term synaptic depression (GO:0060292)2.94671372
130cell communication involved in cardiac conduction (GO:0086065)2.91674726
131stress granule assembly (GO:0034063)2.91156635
132regulation of neurotransmitter secretion (GO:0046928)2.80458778
133cerebellar Purkinje cell differentiation (GO:0021702)2.75767973
134peptidyl-tyrosine autophosphorylation (GO:0038083)2.75640644
135acidic amino acid transport (GO:0015800)2.73993802
136gamma-aminobutyric acid signaling pathway (GO:0007214)2.72322994
137semaphorin-plexin signaling pathway (GO:0071526)2.70075026
138regulation of clathrin-mediated endocytosis (GO:2000369)2.66740489
139sodium ion homeostasis (GO:0055078)2.63705255
140filopodium assembly (GO:0046847)2.63207955
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60828867
142cardiac conduction (GO:0061337)2.58167096
143* female mating behavior (GO:0060180)2.57789835
144regulation of ARF GTPase activity (GO:0032312)2.54841991
145vesicle docking involved in exocytosis (GO:0006904)2.50907234
146neuromuscular process controlling posture (GO:0050884)2.50840130
147L-glutamate transport (GO:0015813)2.49396748
148cerebellar Purkinje cell layer development (GO:0021680)2.49053384
149regulation of neurotransmitter transport (GO:0051588)2.49031815
150negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.44643582
151cGMP-mediated signaling (GO:0019934)2.43657316
152regulation of respiratory burst (GO:0060263)2.42052076
153establishment of synaptic vesicle localization (GO:0097480)2.40998734
154synaptic vesicle transport (GO:0048489)2.40998734
155proline transport (GO:0015824)2.40375708
156regulation of synaptic transmission (GO:0050804)2.38982735
157ethanol metabolic process (GO:0006067)2.38903809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62763274
2* RARB_27405468_Chip-Seq_BRAIN_Mouse4.39102886
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.26065316
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09879150
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09848078
6DROSHA_22980978_ChIP-Seq_HELA_Human2.93637754
7* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.86716742
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83472541
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79123910
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72952137
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72952137
12REST_21632747_ChIP-Seq_MESCs_Mouse2.67167974
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64249022
14* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.63751413
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62279537
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57878453
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57507254
18GBX2_23144817_ChIP-Seq_PC3_Human2.52149035
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50608092
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.39248968
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38785062
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.37409011
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.29885905
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.27809581
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.23304059
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.19455635
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19076755
28AR_21572438_ChIP-Seq_LNCaP_Human1.98819779
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.98599808
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.88904088
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87821420
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83457575
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75875838
34RACK7_27058665_Chip-Seq_MCF-7_Human1.66519307
35* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66184988
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65239948
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61952056
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.57618215
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54815737
40* KDM2B_26808549_Chip-Seq_K562_Human1.54614843
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54267258
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52082729
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51039317
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49824646
45* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46808145
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44146601
47* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42516246
48* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40477163
49* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39158185
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38012859
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35316645
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35300227
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34698241
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34044673
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.33628639
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32600233
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30943465
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29709013
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.28738413
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28225913
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27759776
62CTCF_27219007_Chip-Seq_Bcells_Human1.26232108
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26226825
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25096036
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.23480172
66* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22349437
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20721160
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20481051
69P68_20966046_ChIP-Seq_HELA_Human1.19813177
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.19403048
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19159873
72AR_19668381_ChIP-Seq_PC3_Human1.15952311
73* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14732719
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.14672198
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14481272
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.12988353
77SMAD4_21799915_ChIP-Seq_A2780_Human1.12320578
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11997057
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11657754
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08334573
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07686047
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.07607298
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07179930
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.06185170
85KLF4_19829295_ChIP-Seq_ESCs_Human1.05996545
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05905643
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04557505
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04530635
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.04249831
90TCF7_22412390_ChIP-Seq_EML_Mouse1.02903821
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01172861
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01144729
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00938819
94* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99516593
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99098881
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98327650
97STAT3_23295773_ChIP-Seq_U87_Human0.98205950
98TAF15_26573619_Chip-Seq_HEK293_Human0.98188696
99RXR_22108803_ChIP-Seq_LS180_Human0.97462867
100TP63_22573176_ChIP-Seq_HFKS_Human0.97267722
101GATA1_26923725_Chip-Seq_HPCs_Mouse0.96801217
102NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95261613
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94878103
104KLF5_25053715_ChIP-Seq_YYC3_Human0.93233921
105PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92377226
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.91396588
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91322493
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91119459
109RXR_22158963_ChIP-Seq_LIVER_Mouse0.91008177
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90703728
111SA1_27219007_Chip-Seq_Bcells_Human0.90284354
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90153454
113CTCF_20526341_ChIP-Seq_ESCs_Human0.89087125
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88814959
115* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87969964
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87214635
117FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87137722
118EGR1_19032775_ChIP-ChIP_M12_Human0.87129429
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86973961
120SMC4_20622854_ChIP-Seq_HELA_Human0.86474573
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86355384
122AHR_22903824_ChIP-Seq_MCF-7_Human0.86228677
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85289127
124* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84990292
125LXR_22292898_ChIP-Seq_THP-1_Human0.84844631
126OCT4_19829295_ChIP-Seq_ESCs_Human0.83646132
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83185128
128CREB1_26743006_Chip-Seq_LNCaP_Human0.83064820
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82158173
130* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81628996
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81219594
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.80823575
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80008253
134TCF4_23295773_ChIP-Seq_U87_Human0.79176513
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.79004209
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.77655008
137KDM2B_26808549_Chip-Seq_DND41_Human0.77126054
138* MYC_27129775_Chip-Seq_CORNEA_Mouse0.76227947
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76004619
140* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75658967
141AR_25329375_ChIP-Seq_VCAP_Human0.75555041
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75247553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.29433052
2* MP0003635_abnormal_synaptic_transmissio3.97039194
3MP0003880_abnormal_central_pattern3.69388428
4* MP0009745_abnormal_behavioral_response3.57908715
5* MP0002063_abnormal_learning/memory/cond3.34938742
6MP0004270_analgesia3.14656358
7MP0002064_seizures2.91864362
8MP0001529_abnormal_vocalization2.89893336
9MP0001486_abnormal_startle_reflex2.73697946
10MP0002572_abnormal_emotion/affect_behav2.72165285
11MP0009046_muscle_twitch2.67605192
12MP0002909_abnormal_adrenal_gland2.60817949
13MP0002272_abnormal_nervous_system2.40569200
14MP0005423_abnormal_somatic_nervous2.26170249
15MP0001968_abnormal_touch/_nociception2.24036715
16MP0005670_abnormal_white_adipose2.14474729
17MP0005646_abnormal_pituitary_gland2.07539007
18MP0001501_abnormal_sleep_pattern2.03381247
19MP0002822_catalepsy10.0684685
20MP0002734_abnormal_mechanical_nocicepti1.92969647
21MP0005409_darkened_coat_color1.77378305
22MP0001970_abnormal_pain_threshold1.72613303
23MP0008569_lethality_at_weaning1.72307692
24MP0002733_abnormal_thermal_nociception1.65225265
25MP0003075_altered_response_to1.64175907
26* MP0004924_abnormal_behavior1.63250739
27* MP0005386_behavior/neurological_phenoty1.63250739
28MP0002557_abnormal_social/conspecific_i1.62409612
29MP0005167_abnormal_blood-brain_barrier1.60831757
30MP0004811_abnormal_neuron_physiology1.59772239
31MP0009780_abnormal_chondrocyte_physiolo1.59445969
32MP0010234_abnormal_vibrissa_follicle1.56307761
33MP0001984_abnormal_olfaction1.55396242
34MP0001849_ear_inflammation1.52684077
35MP0005365_abnormal_bile_salt1.51108301
36MP0001440_abnormal_grooming_behavior1.49392792
37MP0002736_abnormal_nociception_after1.47277679
38MP0003879_abnormal_hair_cell1.45583259
39MP0001188_hyperpigmentation1.42608012
40MP0004885_abnormal_endolymph1.41932108
41MP0003183_abnormal_peptide_metabolism1.39799803
42MP0000013_abnormal_adipose_tissue1.38227290
43MP0003705_abnormal_hypodermis_morpholog1.36120389
44MP0000566_synostosis1.35250955
45MP0002067_abnormal_sensory_capabilities1.33521312
46MP0003283_abnormal_digestive_organ1.32278180
47MP0001177_atelectasis1.30807744
48MP0003329_amyloid_beta_deposits1.30469193
49MP0003633_abnormal_nervous_system1.27860211
50MP0008961_abnormal_basal_metabolism1.25231283
51MP0003938_abnormal_ear_development1.24673209
52MP0003123_paternal_imprinting1.23642176
53* MP0002066_abnormal_motor_capabilities/c1.21003770
54MP0000678_abnormal_parathyroid_gland1.19313282
55MP0002876_abnormal_thyroid_physiology1.17099410
56MP0002249_abnormal_larynx_morphology1.15443493
57MP0001905_abnormal_dopamine_level1.15253631
58MP0000955_abnormal_spinal_cord1.13980313
59* MP0008874_decreased_physiological_sensi1.13590070
60MP0009379_abnormal_foot_pigmentation1.09419008
61MP0004264_abnormal_extraembryonic_tissu1.08465586
62MP0005666_abnormal_adipose_tissue1.08211975
63MP0006276_abnormal_autonomic_nervous1.07300479
64MP0003690_abnormal_glial_cell1.06382223
65MP0004147_increased_porphyrin_level1.06209089
66MP0002184_abnormal_innervation1.05692275
67MP0004085_abnormal_heartbeat1.04167478
68MP0002882_abnormal_neuron_morphology1.02128871
69MP0002089_abnormal_postnatal_growth/wei0.99919569
70MP0008875_abnormal_xenobiotic_pharmacok0.99900241
71MP0003172_abnormal_lysosome_physiology0.99313315
72MP0004130_abnormal_muscle_cell0.98409050
73MP0004858_abnormal_nervous_system0.97612774
74MP0002735_abnormal_chemical_nociception0.96981577
75MP0003631_nervous_system_phenotype0.95276115
76MP0005535_abnormal_body_temperature0.95020521
77MP0002090_abnormal_vision0.92972433
78* MP0008872_abnormal_physiological_respon0.92099634
79* MP0002069_abnormal_eating/drinking_beha0.90653320
80MP0004043_abnormal_pH_regulation0.90477585
81MP0004084_abnormal_cardiac_muscle0.90476611
82MP0004019_abnormal_vitamin_homeostasis0.89892187
83MP0001502_abnormal_circadian_rhythm0.88990881
84MP0003045_fibrosis0.88690233
85MP0005375_adipose_tissue_phenotype0.86672386
86MP0000920_abnormal_myelination0.84373190
87MP0000778_abnormal_nervous_system0.82179056
88MP0000537_abnormal_urethra_morphology0.81520923
89MP0002152_abnormal_brain_morphology0.80282174
90MP0003137_abnormal_impulse_conducting0.79834151
91MP0004142_abnormal_muscle_tone0.79623287
92MP0004036_abnormal_muscle_relaxation0.78433548
93MP0000751_myopathy0.77615652
94MP0010329_abnormal_lipoprotein_level0.77048448
95MP0002971_abnormal_brown_adipose0.76850346
96MP0002118_abnormal_lipid_homeostasis0.76541585
97MP0005166_decreased_susceptibility_to0.76352835
98MP0001664_abnormal_digestion0.75205920
99MP0005394_taste/olfaction_phenotype0.75169924
100MP0005499_abnormal_olfactory_system0.75169924
101MP0003787_abnormal_imprinting0.74660810
102MP0005058_abnormal_lysosome_morphology0.74605704
103MP0005360_urolithiasis0.73620488
104MP0000579_abnormal_nail_morphology0.72344061
105MP0002229_neurodegeneration0.67691872
106MP0000569_abnormal_digit_pigmentation0.65870749
107MP0001485_abnormal_pinna_reflex0.64303895
108MP0000631_abnormal_neuroendocrine_gland0.60167848
109MP0003634_abnormal_glial_cell0.59068253
110MP0000604_amyloidosis0.58801810
111MP0005645_abnormal_hypothalamus_physiol0.57366584
112MP0000003_abnormal_adipose_tissue0.55233498
113MP0003300_gastrointestinal_ulcer0.51511472
114MP0001765_abnormal_ion_homeostasis0.50090119
115MP0003632_abnormal_nervous_system0.48084776
116MP0005551_abnormal_eye_electrophysiolog0.45289901
117MP0001943_abnormal_respiration0.44269863
118MP0003956_abnormal_body_size0.43962858
119MP0003866_abnormal_defecation0.43764044
120MP0005584_abnormal_enzyme/coenzyme_acti0.41217065
121MP0000230_abnormal_systemic_arterial0.40972962
122MP0005448_abnormal_energy_balance0.39220664
123MP0005620_abnormal_muscle_contractility0.38832848
124MP0004742_abnormal_vestibular_system0.37394175
125MP0010769_abnormal_survival0.35449883
126MP0001963_abnormal_hearing_physiology0.34661057
127MP0000534_abnormal_ureter_morphology0.34581859
128MP0002082_postnatal_lethality0.33262057
129MP0010770_preweaning_lethality0.33262057
130MP0001666_abnormal_nutrient_absorption0.32505542
131MP0010768_mortality/aging0.32311010
132MP0002752_abnormal_somatic_nervous0.32201419

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.81763177
2Focal motor seizures (HP:0011153)7.36417962
3Focal seizures (HP:0007359)5.52475118
4Annular pancreas (HP:0001734)5.19258775
5Resting tremor (HP:0002322)4.94257105
6Torticollis (HP:0000473)4.78149120
7Ependymoma (HP:0002888)4.23660477
8Hydroxyprolinuria (HP:0003080)4.20767695
9Abnormality of proline metabolism (HP:0010907)4.20767695
10Poor eye contact (HP:0000817)4.18428113
11Focal dystonia (HP:0004373)4.12208273
12Anxiety (HP:0000739)4.08872260
13Action tremor (HP:0002345)4.08203312
14Craniofacial dystonia (HP:0012179)4.07355621
15Ankyloglossia (HP:0010296)4.03139376
16Visual hallucinations (HP:0002367)3.98374734
17Ankle clonus (HP:0011448)3.90526291
18Abnormal social behavior (HP:0012433)3.84047967
19Impaired social interactions (HP:0000735)3.84047967
20Impaired vibration sensation in the lower limbs (HP:0002166)3.74086402
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69913991
22Depression (HP:0000716)3.67667671
23Broad-based gait (HP:0002136)3.45361850
24Prolonged QT interval (HP:0001657)3.40539503
25Polygenic inheritance (HP:0010982)3.38441617
26Dysdiadochokinesis (HP:0002075)3.37196682
27Epileptic encephalopathy (HP:0200134)3.31799887
28Generalized tonic-clonic seizures (HP:0002069)3.28476889
29Pointed chin (HP:0000307)3.26840263
30Astrocytoma (HP:0009592)3.25745889
31Abnormality of the astrocytes (HP:0100707)3.25745889
32Stereotypic behavior (HP:0000733)3.24234797
33Decreased circulating renin level (HP:0003351)3.23161572
34Bronchomalacia (HP:0002780)3.20936839
35Urinary bladder sphincter dysfunction (HP:0002839)3.17898980
36Hyperactive renin-angiotensin system (HP:0000841)3.17136112
37Lower limb amyotrophy (HP:0007210)3.11490282
38Ventricular fibrillation (HP:0001663)3.11148182
39Urinary urgency (HP:0000012)3.08348004
40Abnormality of renin-angiotensin system (HP:0000847)3.07270464
41Gaze-evoked nystagmus (HP:0000640)3.06408639
42Dysmetric saccades (HP:0000641)3.03796544
43Febrile seizures (HP:0002373)3.02725598
44Atrioventricular block (HP:0001678)3.02488124
45Metabolic alkalosis (HP:0200114)3.01615823
46Abnormal EKG (HP:0003115)2.98571254
47Absence seizures (HP:0002121)2.96584208
48Stomach cancer (HP:0012126)2.96226455
49Diplopia (HP:0000651)2.95650568
50Abnormality of binocular vision (HP:0011514)2.95650568
51Abnormality of oral frenula (HP:0000190)2.94912884
52Postural instability (HP:0002172)2.93972087
53Papilledema (HP:0001085)2.93058897
54Dysmetria (HP:0001310)2.91025961
55Scanning speech (HP:0002168)2.88723477
56Dialeptic seizures (HP:0011146)2.79644415
57Upper limb amyotrophy (HP:0009129)2.79350890
58Distal upper limb amyotrophy (HP:0007149)2.79350890
59Abnormal eating behavior (HP:0100738)2.77925866
60Distal lower limb amyotrophy (HP:0008944)2.74188012
61Visceral angiomatosis (HP:0100761)2.67123211
62Megalencephaly (HP:0001355)2.66891411
63Intention tremor (HP:0002080)2.66193151
64Heart block (HP:0012722)2.65470929
65Cerebral aneurysm (HP:0004944)2.62502806
66Abnormality of the lower motor neuron (HP:0002366)2.61467762
67Limb hypertonia (HP:0002509)2.58857303
68Truncal ataxia (HP:0002078)2.58577475
69Spastic gait (HP:0002064)2.55583042
70Axonal loss (HP:0003447)2.54576612
71Supranuclear gaze palsy (HP:0000605)2.52888016
72Atonic seizures (HP:0010819)2.52712649
73Impaired vibratory sensation (HP:0002495)2.51284531
74Akinesia (HP:0002304)2.49364481
75Progressive cerebellar ataxia (HP:0002073)2.47728968
76Bradykinesia (HP:0002067)2.45663295
77Hyperparathyroidism (HP:0000843)2.45074571
78Limb dystonia (HP:0002451)2.43801615
79Clonus (HP:0002169)2.43682568
80Abnormal atrioventricular conduction (HP:0005150)2.43351506
81Impaired smooth pursuit (HP:0007772)2.42079037
82Hemangiomatosis (HP:0007461)2.38322924
83Syncope (HP:0001279)2.35876228
84Bundle branch block (HP:0011710)2.30976139
85Mutism (HP:0002300)2.29713339
86Status epilepticus (HP:0002133)2.27047000
87Neonatal short-limb short stature (HP:0008921)2.26530305
88Lymphangioma (HP:0100764)2.25554187
89Incomplete penetrance (HP:0003829)2.23647149
90Lower limb asymmetry (HP:0100559)2.21638288
91Hyperaldosteronism (HP:0000859)2.20983914
92Truncus arteriosus (HP:0001660)2.20793493
93Hyperglycinuria (HP:0003108)2.20734451
94Hemiplegia (HP:0002301)2.15525557
95Amblyopia (HP:0000646)2.15391967
96Obstructive sleep apnea (HP:0002870)2.14951654
97Glioma (HP:0009733)2.11960111
98Right ventricular cardiomyopathy (HP:0011663)2.09656815
99Hyperventilation (HP:0002883)2.07808521
100Tetraplegia (HP:0002445)2.06356143
101Sleep apnea (HP:0010535)2.05932310
102Abnormality of ocular smooth pursuit (HP:0000617)2.03221153
103Lower limb muscle weakness (HP:0007340)2.03021514
104Neuronal loss in central nervous system (HP:0002529)2.01889864
105Abnormality of the periventricular white matter (HP:0002518)2.01884863
106Nuclear cataract (HP:0100018)2.01004017
107Malnutrition (HP:0004395)2.00844440
108Spinal canal stenosis (HP:0003416)2.00823494
109Dysphonia (HP:0001618)2.00220645
110Hemiparesis (HP:0001269)1.99408056
111Broad metatarsal (HP:0001783)1.97125957
112Flat acetabular roof (HP:0003180)1.96987173
113Spinal cord compression (HP:0002176)1.95889968
114Progressive inability to walk (HP:0002505)1.93853633
115Neurofibrillary tangles (HP:0002185)1.92833377
116Bowel incontinence (HP:0002607)1.92783485
117Onion bulb formation (HP:0003383)1.92270507
118Primary atrial arrhythmia (HP:0001692)1.89028917
119Alkalosis (HP:0001948)1.88938631
120Atrial fibrillation (HP:0005110)1.88229100
121Insomnia (HP:0100785)1.88138185
122Deep palmar crease (HP:0006191)1.87879589
123Spastic tetraparesis (HP:0001285)1.87625496
124Abnormality of saccadic eye movements (HP:0000570)1.86660016
125Alveolar cell carcinoma (HP:0006519)1.85711017
126Obsessive-compulsive behavior (HP:0000722)1.83204854
127Adrenal overactivity (HP:0002717)1.82656804
128Growth hormone excess (HP:0000845)1.81660972
129Neoplasm of the heart (HP:0100544)1.81055061
130Ileus (HP:0002595)1.79523321
131Insidious onset (HP:0003587)1.79352840
132Termporal pattern (HP:0011008)1.79352840
133Aplasia involving bones of the extremities (HP:0009825)1.79245607
134Aplasia involving bones of the upper limbs (HP:0009823)1.79245607
135Aplasia of the phalanges of the hand (HP:0009802)1.79245607
136Cerebral inclusion bodies (HP:0100314)1.79145456
137Delusions (HP:0000746)1.78814380
138Multifactorial inheritance (HP:0001426)1.77976370
139Supraventricular tachycardia (HP:0004755)1.76734953
140Generalized hypotonia (HP:0001290)1.76594245
141Thin bony cortex (HP:0002753)1.74932757
142Confusion (HP:0001289)1.73701193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA48.32094456
2NTRK33.79751137
3MAP3K93.55895189
4MST1R3.44649158
5KSR23.12946985
6MATK2.92089276
7DAPK22.87129849
8FGFR42.80740198
9PRKD32.74037699
10RIPK42.68985856
11CAMKK12.53962313
12EPHA22.14376683
13SIK12.12192772
14TAOK12.06769784
15MAP3K132.04347188
16ARAF2.03952703
17MINK12.01901045
18KSR11.90987007
19FES1.90700111
20PRKCI1.80047003
21MAP3K21.78501186
22NTRK11.76951492
23PTK21.68884605
24TESK11.67358686
25CAMKK21.62311666
26PAK61.61187384
27NTRK21.60421582
28ERN11.55097785
29MAP3K41.54837836
30TYRO31.53546808
31DAPK11.46422055
32* CDK51.43115110
33PKN21.42039029
34MET1.39354746
35PIK3CA1.37955916
36CDK121.37050616
37TNIK1.35620245
38SIK21.32705425
39RAF11.32666894
40MARK11.24826600
41PINK11.15755079
42STK381.14911037
43LMTK21.13469349
44MAP2K61.12668171
45PRPF4B1.09078948
46SGK4941.07847659
47SGK2231.07847659
48NEK11.07214592
49PRKCH1.04606958
50RIPK11.03076257
51MAP2K70.97635474
52BMPR20.96617956
53SGK30.95498197
54SGK20.94366343
55MAP3K10.89342667
56TRIB30.88712548
57MAP2K40.88694523
58MARK20.87562066
59PDPK10.87424367
60STK110.85603118
61ALK0.83796147
62STK390.82664648
63CASK0.80533812
64PRKCG0.79336167
65PDK10.78824873
66LATS20.78667635
67UHMK10.77718653
68RET0.77561506
69MAP2K10.75420184
70PTK60.73262678
71TNK20.73159322
72GRK50.71707064
73CAMK10.71653122
74CAMK2B0.69122201
75PTK2B0.68891269
76CAMK2A0.66387891
77NEK60.64797419
78PAK30.58120318
79WNK10.57629349
80PRKD20.57353391
81DAPK30.56686924
82RPS6KA30.55361827
83BRSK10.54850156
84FYN0.54780324
85* SGK10.54135045
86MAP3K60.53834825
87NME10.53093138
88MAP3K110.53066058
89CAMK40.52973776
90MOS0.52809448
91ROCK10.52772946
92PRKCZ0.52767076
93MAPK120.51632304
94DMPK0.49460237
95CDK30.45149655
96BRAF0.43975178
97MAPK130.43683803
98TAOK20.43620832
99MAPK100.43311156
100RPS6KA20.42456817
101MAP3K120.41970668
102PRKAA10.40794705
103CDK190.40746685
104* CDK140.39049690
105* CDK180.37892894
106OXSR10.37706215
107SRC0.36904434
108PDGFRA0.36772544
109CAMK2G0.36768918
110DDR20.35790189
111BMX0.35758009
112* CDK150.34932303
113PHKG10.34832287
114PHKG20.34832287
115CDC42BPA0.34726849
116SCYL20.32692178
117CAMK2D0.31710680
118PLK20.30314628
119* PRKCB0.28765101
120PRKCA0.28703178
121MAP3K70.27865364
122FGFR20.27634720
123HCK0.27230047
124* CDK11A0.26978470
125ERBB20.26303644
126PRKCE0.25479990
127PRKD10.25441763
128* PRKACA0.23966873
129PRKG20.23739000

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.88163911
2Morphine addiction_Homo sapiens_hsa050322.88100051
3Circadian entrainment_Homo sapiens_hsa047132.72234560
4GABAergic synapse_Homo sapiens_hsa047272.71326359
5Nicotine addiction_Homo sapiens_hsa050332.63760837
6Long-term potentiation_Homo sapiens_hsa047202.61695523
7Synaptic vesicle cycle_Homo sapiens_hsa047212.59131504
8* Amphetamine addiction_Homo sapiens_hsa050312.52590951
9Glutamatergic synapse_Homo sapiens_hsa047242.44824978
10* Cocaine addiction_Homo sapiens_hsa050302.44583144
11* Dopaminergic synapse_Homo sapiens_hsa047282.29137202
12Cholinergic synapse_Homo sapiens_hsa047252.25545796
13Nitrogen metabolism_Homo sapiens_hsa009102.25367701
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24374488
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.15466734
16Salivary secretion_Homo sapiens_hsa049702.09720323
17Renin secretion_Homo sapiens_hsa049242.05198864
18Histidine metabolism_Homo sapiens_hsa003401.94845560
19Gastric acid secretion_Homo sapiens_hsa049711.90287521
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89750291
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89013634
22Oxytocin signaling pathway_Homo sapiens_hsa049211.76645665
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76242082
24Insulin secretion_Homo sapiens_hsa049111.74511356
25Calcium signaling pathway_Homo sapiens_hsa040201.67359680
26Gap junction_Homo sapiens_hsa045401.62777478
27Long-term depression_Homo sapiens_hsa047301.47675047
28Serotonergic synapse_Homo sapiens_hsa047261.47291486
29GnRH signaling pathway_Homo sapiens_hsa049121.46755721
30Arginine and proline metabolism_Homo sapiens_hsa003301.37760551
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34287711
32Taste transduction_Homo sapiens_hsa047421.32380809
33Phenylalanine metabolism_Homo sapiens_hsa003601.30992335
34* cAMP signaling pathway_Homo sapiens_hsa040241.30790517
35Mineral absorption_Homo sapiens_hsa049781.30713686
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29059496
37ABC transporters_Homo sapiens_hsa020101.21581964
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18709105
39Vitamin B6 metabolism_Homo sapiens_hsa007501.17731680
40Glioma_Homo sapiens_hsa052141.14929733
41PPAR signaling pathway_Homo sapiens_hsa033201.10802207
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07695795
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04480085
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.04080075
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03568194
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02057267
47Estrogen signaling pathway_Homo sapiens_hsa049150.98719987
48Type II diabetes mellitus_Homo sapiens_hsa049300.98221731
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.94753027
50Non-small cell lung cancer_Homo sapiens_hsa052230.94353929
51Melanogenesis_Homo sapiens_hsa049160.91508720
52Fructose and mannose metabolism_Homo sapiens_hsa000510.91284035
53Pancreatic secretion_Homo sapiens_hsa049720.88752362
54Thyroid hormone synthesis_Homo sapiens_hsa049180.85910817
55Glycerolipid metabolism_Homo sapiens_hsa005610.85757332
56ErbB signaling pathway_Homo sapiens_hsa040120.83749602
57Fat digestion and absorption_Homo sapiens_hsa049750.83380345
58Oocyte meiosis_Homo sapiens_hsa041140.82137725
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81290455
60Cardiac muscle contraction_Homo sapiens_hsa042600.81287534
61Phototransduction_Homo sapiens_hsa047440.80886602
62* Alcoholism_Homo sapiens_hsa050340.80196508
63Rap1 signaling pathway_Homo sapiens_hsa040150.79784337
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79381667
65Bile secretion_Homo sapiens_hsa049760.78805864
66Dorso-ventral axis formation_Homo sapiens_hsa043200.77458193
67Fatty acid biosynthesis_Homo sapiens_hsa000610.77297668
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76434420
69Tyrosine metabolism_Homo sapiens_hsa003500.76064150
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75947320
71Other glycan degradation_Homo sapiens_hsa005110.75343829
72Dilated cardiomyopathy_Homo sapiens_hsa054140.75133998
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74563285
74VEGF signaling pathway_Homo sapiens_hsa043700.70893948
75beta-Alanine metabolism_Homo sapiens_hsa004100.70796973
76Axon guidance_Homo sapiens_hsa043600.70136373
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68649838
78Type I diabetes mellitus_Homo sapiens_hsa049400.67611192
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65409242
80Choline metabolism in cancer_Homo sapiens_hsa052310.64075136
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63306637
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.62092712
83Collecting duct acid secretion_Homo sapiens_hsa049660.61706195
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61631800
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61533619
86MAPK signaling pathway_Homo sapiens_hsa040100.59691838
87Protein digestion and absorption_Homo sapiens_hsa049740.59025664
88AMPK signaling pathway_Homo sapiens_hsa041520.56910881
89Chemokine signaling pathway_Homo sapiens_hsa040620.56017854
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55920263
91mTOR signaling pathway_Homo sapiens_hsa041500.55154018
92Thyroid cancer_Homo sapiens_hsa052160.54795766
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53499411
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.52639235
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52478126
96Arginine biosynthesis_Homo sapiens_hsa002200.52146493
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51518535
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51200276
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49051324
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47308888
101Butanoate metabolism_Homo sapiens_hsa006500.47285586
102Endometrial cancer_Homo sapiens_hsa052130.47265664
103Ras signaling pathway_Homo sapiens_hsa040140.46896463
104Fatty acid degradation_Homo sapiens_hsa000710.46504909
105Glucagon signaling pathway_Homo sapiens_hsa049220.45720344
106Endocytosis_Homo sapiens_hsa041440.45538623
107Sulfur metabolism_Homo sapiens_hsa009200.44420917
108Prion diseases_Homo sapiens_hsa050200.43947622
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42835815
110Platelet activation_Homo sapiens_hsa046110.41698957
111Vibrio cholerae infection_Homo sapiens_hsa051100.40285362
112Inositol phosphate metabolism_Homo sapiens_hsa005620.38334630
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38127593
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38121650
115African trypanosomiasis_Homo sapiens_hsa051430.37913096
116Renin-angiotensin system_Homo sapiens_hsa046140.37019404
117Sphingolipid metabolism_Homo sapiens_hsa006000.35196980
118Notch signaling pathway_Homo sapiens_hsa043300.35107797
119HIF-1 signaling pathway_Homo sapiens_hsa040660.34947502
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34476687
121Circadian rhythm_Homo sapiens_hsa047100.34128457
122Renal cell carcinoma_Homo sapiens_hsa052110.33087317
123Insulin signaling pathway_Homo sapiens_hsa049100.31288595
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.30805773
125Ovarian steroidogenesis_Homo sapiens_hsa049130.30284021
126Tight junction_Homo sapiens_hsa045300.27459118
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25685843
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24910222
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22748989
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20436581

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