PPP1R18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.42398061
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.42398061
3positive regulation of gamma-delta T cell activation (GO:0046645)5.38663513
4antigen processing and presentation of endogenous antigen (GO:0019883)5.02424312
5leukocyte aggregation (GO:0070486)4.66847972
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46229117
7regulation of B cell receptor signaling pathway (GO:0050855)4.28904984
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28606102
9detection of other organism (GO:0098543)4.28563316
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16544950
11negative regulation of cell killing (GO:0031342)4.16544950
12positive thymic T cell selection (GO:0045059)4.15894702
13detection of bacterium (GO:0016045)4.13782994
14regulation of gamma-delta T cell differentiation (GO:0045586)4.07435518
15regulation of gamma-delta T cell activation (GO:0046643)3.87931156
16negative regulation of phagocytosis (GO:0050765)3.76251106
17negative thymic T cell selection (GO:0045060)3.76217153
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75598821
19negative T cell selection (GO:0043383)3.71513711
20detection of external biotic stimulus (GO:0098581)3.70876569
21T cell migration (GO:0072678)3.65240867
22positive regulation by symbiont of host defense response (GO:0052509)3.64234161
23modulation by symbiont of host defense response (GO:0052031)3.64234161
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64234161
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64234161
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.64234161
27modulation by symbiont of host immune response (GO:0052553)3.64234161
28detection of molecule of bacterial origin (GO:0032490)3.61932485
29regulation of B cell differentiation (GO:0045577)3.54886279
30B cell receptor signaling pathway (GO:0050853)3.53261340
31regulation of interleukin-12 biosynthetic process (GO:0045075)3.51021939
32thymic T cell selection (GO:0045061)3.49805742
33negative regulation of erythrocyte differentiation (GO:0045647)3.45614721
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44453611
35cellular extravasation (GO:0045123)3.42607111
36tolerance induction (GO:0002507)3.41290953
37positive regulation of B cell differentiation (GO:0045579)3.40406064
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40105146
39response to host immune response (GO:0052572)3.40105146
40germinal center formation (GO:0002467)3.38972269
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.35637258
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35315165
43response to interleukin-15 (GO:0070672)3.31883539
44leukocyte cell-cell adhesion (GO:0007159)3.31292940
45regulation of mast cell degranulation (GO:0043304)3.30877003
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28665768
47response to host (GO:0075136)3.28665768
48response to host defenses (GO:0052200)3.28665768
49granulocyte activation (GO:0036230)3.28641034
50immunoglobulin mediated immune response (GO:0016064)3.27762300
51detection of biotic stimulus (GO:0009595)3.23961505
52positive regulation of lamellipodium assembly (GO:0010592)3.23158988
53myeloid cell activation involved in immune response (GO:0002275)3.19322054
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19245555
55negative regulation of leukocyte mediated immunity (GO:0002704)3.18969209
56positive T cell selection (GO:0043368)3.16845012
57negative regulation of interleukin-12 production (GO:0032695)3.15293479
58negative regulation of T cell mediated immunity (GO:0002710)3.14494291
59antigen processing and presentation via MHC class Ib (GO:0002475)3.13620949
60T cell selection (GO:0045058)3.10464793
61regulation of interferon-beta biosynthetic process (GO:0045357)3.10103779
62regulation of T cell tolerance induction (GO:0002664)3.08244198
63regulation of T-helper 2 cell differentiation (GO:0045628)3.07433497
64regulation of leukocyte degranulation (GO:0043300)3.05688147
65NIK/NF-kappaB signaling (GO:0038061)3.01581709
66macrophage activation (GO:0042116)3.01341167
67regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00015485
68regulation of mast cell activation involved in immune response (GO:0033006)2.99887137
69cellular response to interleukin-15 (GO:0071350)2.98663684
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98571636
71interferon-gamma production (GO:0032609)2.96828466
72antigen receptor-mediated signaling pathway (GO:0050851)2.96571819
73response to muramyl dipeptide (GO:0032495)2.96330869
74microglial cell activation (GO:0001774)2.94372166
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92074923
76T cell costimulation (GO:0031295)2.91802971
77negative regulation of cytokine production involved in immune response (GO:0002719)2.89602468
78JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.89198862
79regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88239923
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87554149
81response to laminar fluid shear stress (GO:0034616)2.86969594
82lymphocyte costimulation (GO:0031294)2.86731820
83T cell receptor signaling pathway (GO:0050852)2.85278053
84positive regulation of mast cell activation (GO:0033005)2.84066259
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83839481
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83493078
87neutrophil activation involved in immune response (GO:0002283)2.82556609
88positive regulation of lamellipodium organization (GO:1902745)2.82272304
89sequestering of actin monomers (GO:0042989)2.81811193
90positive regulation of isotype switching (GO:0045830)2.80022320
91T-helper 1 type immune response (GO:0042088)2.79286982
92negative regulation of type 2 immune response (GO:0002829)2.78405777
93regulation of antigen processing and presentation (GO:0002577)2.78378751
94natural killer cell differentiation (GO:0001779)2.77532723
95actin nucleation (GO:0045010)2.75579014
96myeloid dendritic cell activation (GO:0001773)2.74557163
97respiratory burst (GO:0045730)2.74500204
98production of molecular mediator involved in inflammatory response (GO:0002532)2.74274392
99B cell mediated immunity (GO:0019724)2.73609800
100regulation of T cell mediated cytotoxicity (GO:0001914)2.72751808
101positive regulation of interferon-alpha production (GO:0032727)2.72743122
102regulation of mast cell activation (GO:0033003)2.72465538
103morphogenesis of an endothelium (GO:0003159)2.72317051
104endothelial tube morphogenesis (GO:0061154)2.72317051
105leukocyte migration involved in inflammatory response (GO:0002523)2.72031566
106positive regulation of histone deacetylation (GO:0031065)2.71515632
107response to peptidoglycan (GO:0032494)2.70561612
108regulation of alpha-beta T cell proliferation (GO:0046640)2.69796293
109negative regulation of granulocyte differentiation (GO:0030853)2.69143726
110positive regulation of tolerance induction (GO:0002645)2.69067118
111response to type I interferon (GO:0034340)2.69031999
112regulation of type 2 immune response (GO:0002828)2.68273241
113interferon-gamma-mediated signaling pathway (GO:0060333)2.67400630
114negative regulation of interleukin-6 production (GO:0032715)2.67012833
115regulation of interferon-alpha production (GO:0032647)2.66139516
116negative regulation of innate immune response (GO:0045824)2.66084085
117positive regulation of macrophage differentiation (GO:0045651)2.65424113
118myeloid dendritic cell differentiation (GO:0043011)2.64852345
119positive regulation of type 2 immune response (GO:0002830)2.64534760
120regulation of macrophage cytokine production (GO:0010935)2.64289737
121type I interferon signaling pathway (GO:0060337)2.64142460
122cellular response to type I interferon (GO:0071357)2.64142460
123regulation of response to interferon-gamma (GO:0060330)2.63807881
124macrophage activation involved in immune response (GO:0002281)2.63448196
125negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.63382750
126response to protozoan (GO:0001562)2.63166349
127mature B cell differentiation (GO:0002335)2.62418880
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.58012169
129cellular response to zinc ion (GO:0071294)2.56580101
130T cell homeostasis (GO:0043029)2.56544918
131immune response-activating cell surface receptor signaling pathway (GO:0002429)2.56302328
132neutrophil activation (GO:0042119)2.55971130
133lymphocyte homeostasis (GO:0002260)2.55663099
134defense response to protozoan (GO:0042832)2.54053480
135positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53747765
136regulation of T cell receptor signaling pathway (GO:0050856)2.53396808
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50562440
138regulation of tolerance induction (GO:0002643)2.50422957
139pinocytosis (GO:0006907)2.50036632
140positive regulation of interleukin-2 production (GO:0032743)2.49709292
141regulation of natural killer cell mediated immunity (GO:0002715)2.49034169
142regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.49034169
143positive regulation of antigen processing and presentation (GO:0002579)2.48709294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.27901729
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.90602342
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.72336121
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.68204864
5MYC_22102868_ChIP-Seq_BL_Human3.46041945
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.38708569
7E2F7_22180533_ChIP-Seq_HELA_Human3.32591450
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12653924
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12570122
10VDR_21846776_ChIP-Seq_THP-1_Human2.93667212
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81831050
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.66939565
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64417560
14MAF_26560356_Chip-Seq_TH1_Human2.59803927
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54382067
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52424147
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49568018
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.44377567
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43826929
20MYB_26560356_Chip-Seq_TH2_Human2.39205498
21UTX_26944678_Chip-Seq_JUKART_Human2.32985365
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32685115
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30938199
24RUNX_20019798_ChIP-Seq_JUKART_Human2.26311446
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24718497
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24311898
27TCF7_22412390_ChIP-Seq_EML_Mouse2.20863752
28SCL_19346495_ChIP-Seq_HPC-7_Human2.17527700
29VDR_24763502_ChIP-Seq_THP-1_Human2.16614769
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12294297
31MYB_26560356_Chip-Seq_TH1_Human2.10732945
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.10420702
33* SPI1_23547873_ChIP-Seq_NB4_Human2.07041054
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06860777
35STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05194223
36ELK3_25401928_ChIP-Seq_HUVEC_Human2.04938076
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04123321
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00926771
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.99294948
40KDM2B_26808549_Chip-Seq_DND41_Human1.88040178
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87098823
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87046092
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85934894
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82201263
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80346823
46SPI1_23127762_ChIP-Seq_K562_Human1.74005188
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70349320
48MAF_26560356_Chip-Seq_TH2_Human1.67294141
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66564356
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.59365295
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56687637
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55543804
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47884700
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46935282
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.43921682
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37944602
57GATA3_27048872_Chip-Seq_THYMUS_Human1.35151204
58PU_27001747_Chip-Seq_BMDM_Mouse1.25980415
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24439065
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23823021
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23662770
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21950031
63LXR_22292898_ChIP-Seq_THP-1_Human1.21282099
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.20827341
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20161234
66GATA1_19941826_ChIP-Seq_K562_Human1.19665565
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19459428
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19205327
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18989451
70CIITA_25753668_ChIP-Seq_RAJI_Human1.18771980
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14239560
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14007193
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.13604223
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11420819
75NCOR1_26117541_ChIP-Seq_K562_Human1.10630883
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10527059
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09625833
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09599001
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08928955
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08339638
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07317381
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06857520
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05619246
84KDM2B_26808549_Chip-Seq_K562_Human1.05466023
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04218290
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04161537
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02659172
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02369087
89BCL6_27268052_Chip-Seq_Bcells_Human1.01454884
90BCOR_27268052_Chip-Seq_Bcells_Human0.98259823
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97230796
92TFEB_21752829_ChIP-Seq_HELA_Human0.94933121
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.94722438
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90647965
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.90575743
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89784652
97RACK7_27058665_Chip-Seq_MCF-7_Human0.89199148
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87355714
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87350678
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85941303
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85275520
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84586796
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.83055999
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82493401
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82185140
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81670952
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81290391
108VDR_24787735_ChIP-Seq_THP-1_Human0.80814750
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79789177
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79477037
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79152422
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78601686
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.78476011
114GATA3_26560356_Chip-Seq_TH2_Human0.78293503
115CLOCK_20551151_ChIP-Seq_293T_Human0.78168755
116RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77727315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.42107697
2MP0003303_peritoneal_inflammation3.16013755
3MP0000685_abnormal_immune_system3.12321040
4MP0003436_decreased_susceptibility_to2.99897415
5MP0005671_abnormal_response_to2.80084976
6MP0001800_abnormal_humoral_immune2.75607817
7MP0005387_immune_system_phenotype2.74354092
8MP0001790_abnormal_immune_system2.74354092
9MP0005000_abnormal_immune_tolerance2.58314641
10MP0009785_altered_susceptibility_to2.54577957
11MP0002452_abnormal_antigen_presenting2.53188890
12MP0003763_abnormal_thymus_physiology2.51099172
13MP0003300_gastrointestinal_ulcer2.42835454
14MP0002420_abnormal_adaptive_immunity2.38381314
15MP0001819_abnormal_immune_cell2.36371975
16MP0002723_abnormal_immune_serum2.34865942
17MP0005025_abnormal_response_to2.31230346
18MP0009278_abnormal_bone_marrow2.29865505
19MP0002419_abnormal_innate_immunity2.24073435
20MP0002398_abnormal_bone_marrow2.20910853
21MP0002396_abnormal_hematopoietic_system2.18605038
22MP0002405_respiratory_system_inflammati2.15653585
23MP0009333_abnormal_splenocyte_physiolog2.13668053
24MP0006082_CNS_inflammation2.09770309
25MP0010352_gastrointestinal_tract_polyps2.09658459
26MP0004808_abnormal_hematopoietic_stem2.01588733
27MP0000716_abnormal_immune_system1.97538317
28MP0005464_abnormal_platelet_physiology1.94001669
29MP0002166_altered_tumor_susceptibility1.93964074
30MP0002148_abnormal_hypersensitivity_rea1.93932056
31MP0005451_abnormal_body_composition1.90212896
32MP0004510_myositis1.87478457
33MP0004947_skin_inflammation1.87317511
34MP0000689_abnormal_spleen_morphology1.84131135
35MP0002722_abnormal_immune_system1.81612245
36MP0010155_abnormal_intestine_physiology1.77212819
37MP0002933_joint_inflammation1.72561259
38MP0003724_increased_susceptibility_to1.71881289
39MP0001853_heart_inflammation1.71443276
40MP0001533_abnormal_skeleton_physiology1.69610526
41MP0002429_abnormal_blood_cell1.67976174
42MP0003566_abnormal_cell_adhesion1.66860193
43MP0000703_abnormal_thymus_morphology1.64249267
44MP0000858_altered_metastatic_potential1.63802712
45MP0003448_altered_tumor_morphology1.63378683
46MP0001545_abnormal_hematopoietic_system1.63238657
47MP0005397_hematopoietic_system_phenotyp1.63238657
48MP0008260_abnormal_autophagy1.62089818
49MP0005076_abnormal_cell_differentiation1.61695126
50MP0008438_abnormal_cutaneous_collagen1.61400653
51MP0003279_aneurysm1.58484732
52MP0002006_tumorigenesis1.57260409
53MP0001845_abnormal_inflammatory_respons1.53309511
54MP0005023_abnormal_wound_healing1.52947931
55MP0001873_stomach_inflammation1.47381170
56MP0003705_abnormal_hypodermis_morpholog1.47011520
57MP0000465_gastrointestinal_hemorrhage1.39194729
58MP0000490_abnormal_crypts_of1.34553133
59MP0005058_abnormal_lysosome_morphology1.29141183
60MP0003866_abnormal_defecation1.22806897
61MP0003091_abnormal_cell_migration1.22255805
62MP0000343_altered_response_to1.17080353
63MP0005164_abnormal_response_to1.16449777
64MP0004883_abnormal_blood_vessel1.15243180
65MP0010307_abnormal_tumor_latency1.15019749
66MP0002132_abnormal_respiratory_system1.12680059
67MP0003828_pulmonary_edema1.09764102
68MP0000604_amyloidosis1.09195508
69MP0001851_eye_inflammation1.08003676
70MP0006054_spinal_hemorrhage1.07442465
71MP0002998_abnormal_bone_remodeling1.07110910
72MP0008469_abnormal_protein_level1.05918741
73MP0003183_abnormal_peptide_metabolism1.05141986
74MP0003172_abnormal_lysosome_physiology1.04281343
75MP0003045_fibrosis1.01504236
76MP0002019_abnormal_tumor_incidence0.99705292
77MP0005390_skeleton_phenotype0.97363257
78MP0001958_emphysema0.97235527
79MP0000733_abnormal_muscle_development0.90900021
80MP0005310_abnormal_salivary_gland0.89369545
81MP0008004_abnormal_stomach_pH0.88157628
82MP0001849_ear_inflammation0.87767509
83MP0002138_abnormal_hepatobiliary_system0.87678599
84MP0004381_abnormal_hair_follicle0.87225488
85MP0003690_abnormal_glial_cell0.85671674
86MP0003453_abnormal_keratinocyte_physiol0.83953392
87MP0000767_abnormal_smooth_muscle0.83932483
88MP0001663_abnormal_digestive_system0.83425698
89MP0003191_abnormal_cellular_cholesterol0.81735597
90MP0008007_abnormal_cellular_replicative0.81423474
91MP0000249_abnormal_blood_vessel0.80908993
92MP0001542_abnormal_bone_strength0.79940890
93MP0005174_abnormal_tail_pigmentation0.74988305
94MP0001915_intracranial_hemorrhage0.74966419
95MP0003795_abnormal_bone_structure0.73121605
96MP0003077_abnormal_cell_cycle0.72413232
97MP0002332_abnormal_exercise_endurance0.71954516
98MP0009764_decreased_sensitivity_to0.71747225
99MP0004858_abnormal_nervous_system0.70283824
100MP0000569_abnormal_digit_pigmentation0.70201221
101MP0005166_decreased_susceptibility_to0.68333043
102MP0009840_abnormal_foam_cell0.67217930
103MP0001243_abnormal_dermal_layer0.66577467
104MP0002277_abnormal_respiratory_mucosa0.66403819
105MP0008874_decreased_physiological_sensi0.65309598
106MP0000477_abnormal_intestine_morphology0.62778803
107MP0009763_increased_sensitivity_to0.62504889
108MP0003656_abnormal_erythrocyte_physiolo0.60221898
109MP0009765_abnormal_xenobiotic_induced0.59213439
110MP0001879_abnormal_lymphatic_vessel0.58875981
111MP0003075_altered_response_to0.58626523
112MP0000350_abnormal_cell_proliferation0.58263646
113MP0005275_abnormal_skin_tensile0.56488375
114MP0002925_abnormal_cardiovascular_devel0.55259449
115MP0008961_abnormal_basal_metabolism0.55164464
116MP0005621_abnormal_cell_physiology0.54864630
117MP0000313_abnormal_cell_death0.54864227
118MP0002877_abnormal_melanocyte_morpholog0.54833652
119MP0003693_abnormal_embryo_hatching0.52810625
120MP0001348_abnormal_lacrimal_gland0.52132389

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.53859126
2Recurrent abscess formation (HP:0002722)4.40309849
3Elevated erythrocyte sedimentation rate (HP:0003565)4.05449934
4Myositis (HP:0100614)3.70681705
5Cellulitis (HP:0100658)3.66698151
6Recurrent fungal infections (HP:0002841)3.65391261
7Recurrent bacterial skin infections (HP:0005406)3.63150516
8Recurrent bronchitis (HP:0002837)3.53229514
9Recurrent viral infections (HP:0004429)3.43061111
10IgM deficiency (HP:0002850)3.41522413
11Chronic otitis media (HP:0000389)3.41237056
12Gastrointestinal infarctions (HP:0005244)3.35342435
13Nasal polyposis (HP:0100582)3.26553498
14Stomatitis (HP:0010280)3.25797670
15Abnormality of the nasal mucosa (HP:0000433)3.09182883
16T lymphocytopenia (HP:0005403)3.05339361
17Spontaneous hematomas (HP:0007420)3.01872890
18Meningitis (HP:0001287)2.99292880
19Abnormality of liposaccharide metabolism (HP:0010968)2.98123310
20Abnormality of glycosphingolipid metabolism (HP:0004343)2.98123310
21Abnormality of glycolipid metabolism (HP:0010969)2.98123310
22Abnormality of T cell number (HP:0011839)2.96506715
23Mediastinal lymphadenopathy (HP:0100721)2.92397135
24Keratoconjunctivitis sicca (HP:0001097)2.92041893
25Agammaglobulinemia (HP:0004432)2.91896387
26Increased density of long bones (HP:0006392)2.86093860
27Abnormality of T cells (HP:0002843)2.84413725
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.84393194
29Encephalitis (HP:0002383)2.83364525
30Chronic obstructive pulmonary disease (HP:0006510)2.81820581
31Obstructive lung disease (HP:0006536)2.81820581
32Gastrointestinal inflammation (HP:0004386)2.81718269
33Recurrent cutaneous fungal infections (HP:0011370)2.81002332
34Chronic mucocutaneous candidiasis (HP:0002728)2.81002332
35Inflammation of the large intestine (HP:0002037)2.79537183
36Panhypogammaglobulinemia (HP:0003139)2.78913632
37Cerebral aneurysm (HP:0004944)2.76620425
38Recurrent skin infections (HP:0001581)2.73611888
39Orchitis (HP:0100796)2.72578509
40Autoimmune thrombocytopenia (HP:0001973)2.71663133
41Thrombocytosis (HP:0001894)2.68315487
42Recurrent gram-negative bacterial infections (HP:0005420)2.67823148
43Pustule (HP:0200039)2.66843166
44Abnormality of macrophages (HP:0004311)2.64735535
45Keratoconjunctivitis (HP:0001096)2.61004038
46Vasculitis (HP:0002633)2.59738342
47Verrucae (HP:0200043)2.54031860
48Papilloma (HP:0012740)2.54031860
49Gingivitis (HP:0000230)2.51144981
50Colitis (HP:0002583)2.50614200
51Lymphopenia (HP:0001888)2.50547715
52Abnormality of T cell physiology (HP:0011840)2.49596717
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.46736797
54Protrusio acetabuli (HP:0003179)2.46140774
55Hematochezia (HP:0002573)2.44874223
56Amyloidosis (HP:0011034)2.40992378
57Emphysema (HP:0002097)2.39906062
58Leukocytosis (HP:0001974)2.39806424
59Interstitial pulmonary disease (HP:0006530)2.37365165
60Dysostosis multiplex (HP:0000943)2.37176163
61Thyroiditis (HP:0100646)2.35747930
62Arterial thrombosis (HP:0004420)2.32118426
63Optic neuritis (HP:0100653)2.31246223
64Retrobulbar optic neuritis (HP:0100654)2.31246223
65Episodic fever (HP:0001954)2.28621364
66Gingival bleeding (HP:0000225)2.27876823
67Severe combined immunodeficiency (HP:0004430)2.27686899
68Combined immunodeficiency (HP:0005387)2.27293986
69Purpura (HP:0000979)2.26377342
70Peritonitis (HP:0002586)2.25761537
71Loss of speech (HP:0002371)2.24353083
72Abnormal platelet volume (HP:0011876)2.24215046
73Abnormality of the fingertips (HP:0001211)2.24091561
74Aortic aneurysm (HP:0004942)2.23407769
75Increased IgE level (HP:0003212)2.22767723
76Abnormality of the peritoneum (HP:0002585)2.21205460
77Chest pain (HP:0100749)2.19181832
78IgG deficiency (HP:0004315)2.18297813
79Osteomyelitis (HP:0002754)2.18010703
80Prolonged bleeding time (HP:0003010)2.16467083
81Aortic dissection (HP:0002647)2.15891888
82Dilatation of the ascending aorta (HP:0005111)2.14611752
83Granulocytopenia (HP:0001913)2.13879369
84Increased cerebral lipofuscin (HP:0011813)2.13055573
85IgA deficiency (HP:0002720)2.12386370
86Pulmonary embolism (HP:0002204)2.08654812
87Pulmonary infiltrates (HP:0002113)2.08460928
88Hemoptysis (HP:0002105)2.07288826
89Hypochromic anemia (HP:0001931)2.05951551
90Eosinophilia (HP:0001880)2.05785788
91Petechiae (HP:0000967)2.05347584
92Segmental peripheral demyelination/remyelination (HP:0003481)2.04411711
93Skin ulcer (HP:0200042)2.03684766
94Periodontitis (HP:0000704)2.03232573
95Glomerulopathy (HP:0100820)2.02410646
96Spondylolisthesis (HP:0003302)2.01712081
97Vacuolated lymphocytes (HP:0001922)2.00389007
98Anorexia (HP:0002039)1.99342321
99Increased serum ferritin (HP:0003281)1.98369556
100Gastrointestinal stroma tumor (HP:0100723)1.97777996
101Osteolytic defects of the hand bones (HP:0009699)1.96844259
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.96844259
103Hypergammaglobulinemia (HP:0010702)1.96044370
104Polycythemia (HP:0001901)1.95375963
105Epistaxis (HP:0000421)1.93751006
106Hepatosplenomegaly (HP:0001433)1.92740983
107Abnormality of eosinophils (HP:0001879)1.90184518
108Premature loss of primary teeth (HP:0006323)1.90182392
109Premature rupture of membranes (HP:0001788)1.89375796
110Increased neuronal autofluorescent lipopigment (HP:0002074)1.89048144
111Chronic sinusitis (HP:0011109)1.88567654
112Bicuspid aortic valve (HP:0001647)1.87784866
113Abnormality of the pleura (HP:0002103)1.87228230
114Cervical subluxation (HP:0003308)1.85160027
115Abnormal platelet function (HP:0011869)1.84398728
116Impaired platelet aggregation (HP:0003540)1.84398728
117B lymphocytopenia (HP:0010976)1.84249823
118Abnormality of B cell number (HP:0010975)1.84249823
119Hypochromic microcytic anemia (HP:0004840)1.83957878
120Urticaria (HP:0001025)1.83368605
121Increased IgM level (HP:0003496)1.83284729
122Spinal cord lesions (HP:0100561)1.83166446
123Syringomyelia (HP:0003396)1.83166446
124Recurrent lower respiratory tract infections (HP:0002783)1.82996666
125Sepsis (HP:0100806)1.82838848
126Restrictive lung disease (HP:0002091)1.82827491
127Gangrene (HP:0100758)1.82774092
128Abnormality of the pericardium (HP:0001697)1.82765286
129Slow saccadic eye movements (HP:0000514)1.82107672
130Systemic lupus erythematosus (HP:0002725)1.81988946
131Hypertensive crisis (HP:0100735)1.81246282
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79610781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.62689541
2PRPF4B2.97689893
3MAP3K102.85382872
4TRIB32.70425012
5ERN12.69566952
6TXK2.49766287
7EEF2K2.39585348
8STK102.36265396
9PKN22.36083182
10ZAP702.27442485
11JAK32.24180917
12TYK22.22306846
13BLK2.15165401
14TBK12.12170122
15TESK21.85565029
16BTK1.84155502
17KIT1.78861070
18LRRK21.77727327
19ITK1.76727267
20IKBKE1.73331474
21TGFBR21.72037293
22GRK61.68942619
23TTN1.68063958
24CSF1R1.64960508
25IRAK41.62386606
26KDR1.57429934
27RPS6KA41.54967548
28HCK1.51931016
29MAP3K141.49648402
30JAK11.47043746
31FGFR41.45854284
32TAOK21.45546905
33CSK1.45061327
34EPHB11.33937419
35SYK1.33505961
36LCK1.32886788
37IKBKB1.29692856
38MAP2K31.28929004
39CDK121.28707834
40TEC1.28405530
41SIK21.25212806
42SMG11.20724634
43MAP3K11.19713883
44NME21.19197441
45CLK11.18650604
46PTK61.17315241
47FGFR31.14898080
48KSR21.14496019
49PIM11.11455179
50CDC42BPA1.07932227
51MATK1.05267839
52PIM21.04800145
53FES1.04035205
54MOS1.03627647
55MARK30.99674927
56TESK10.99161693
57PAK40.97106793
58TAOK30.95657172
59FLT30.90514840
60MARK20.88000627
61LYN0.87287911
62CHUK0.87205873
63NEK20.85835748
64GRK70.84948115
65TGFBR10.84514619
66BMPR20.79556994
67NLK0.79200660
68RIPK10.77434587
69RIPK40.76749122
70MAP3K110.76519052
71BMX0.76362765
72IRAK20.74253030
73IRAK30.72530337
74PDPK10.70717342
75DDR20.70179446
76PDK10.70177045
77TRPM70.69663687
78CDK40.69311652
79YES10.68276251
80ICK0.66146030
81SIK30.66057675
82ALK0.65510201
83IRAK10.65472646
84JAK20.64460702
85MAPK70.62836534
86CDK60.62426762
87SIK10.62302991
88MAP3K60.61520898
89MAP3K80.61388068
90PRKCH0.60881232
91MAPK120.58165879
92PTK2B0.56810827
93EPHA30.56153750
94MAP3K130.54781477
95DMPK0.54616054
96MAPKAPK20.53381187
97FYN0.53174140
98TNK20.53140209
99MAP3K30.52679746
100TAOK10.52158614
101RPS6KB20.51125908
102RPS6KA60.50185369
103STK40.49789979
104MAP3K70.49488571
105SCYL20.48516825
106PRKD20.46858185
107ILK0.46085499
108PAK20.45891228
109STK380.45501942
110CAMK1D0.45124821
111PDGFRB0.44877622
112RPS6KA20.44430018
113ARAF0.43325290
114PIK3CG0.43252109
115MAP3K50.42757504
116PDGFRA0.42274827
117FGR0.41878361
118ABL10.41725956
119NEK90.41671196
120PTK20.40909757
121RPS6KC10.40585859
122RPS6KL10.40585859
123DYRK1B0.39142271
124PRKG20.38209260
125PRKCQ0.37515242
126EGFR0.37126844
127INSR0.36527171
128MAPK40.36307292
129MAPKAPK30.34520283
130HIPK20.34253418
131MTOR0.33188489

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.17444567
2Leishmaniasis_Homo sapiens_hsa051402.60200153
3B cell receptor signaling pathway_Homo sapiens_hsa046622.35973451
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.21364395
5Osteoclast differentiation_Homo sapiens_hsa043802.20548799
6Measles_Homo sapiens_hsa051622.05593569
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98776927
8Antigen processing and presentation_Homo sapiens_hsa046121.97829115
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97074244
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91099677
11T cell receptor signaling pathway_Homo sapiens_hsa046601.90100939
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.89419164
13Hematopoietic cell lineage_Homo sapiens_hsa046401.80127957
14Viral myocarditis_Homo sapiens_hsa054161.75310595
15Shigellosis_Homo sapiens_hsa051311.73038376
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.67436412
17Toxoplasmosis_Homo sapiens_hsa051451.65008910
18Malaria_Homo sapiens_hsa051441.61445738
19Allograft rejection_Homo sapiens_hsa053301.59735954
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59199273
21Type I diabetes mellitus_Homo sapiens_hsa049401.56434317
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56309192
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53478962
24Chronic myeloid leukemia_Homo sapiens_hsa052201.53154134
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52109085
26Staphylococcus aureus infection_Homo sapiens_hsa051501.50413671
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.44098101
28Graft-versus-host disease_Homo sapiens_hsa053321.42907526
29Acute myeloid leukemia_Homo sapiens_hsa052211.42734067
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40941610
31Herpes simplex infection_Homo sapiens_hsa051681.40428991
32Apoptosis_Homo sapiens_hsa042101.39501137
33Legionellosis_Homo sapiens_hsa051341.38475940
34Pertussis_Homo sapiens_hsa051331.38145358
35Tuberculosis_Homo sapiens_hsa051521.34751432
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33700151
37TNF signaling pathway_Homo sapiens_hsa046681.32949092
38Hepatitis B_Homo sapiens_hsa051611.31955232
39Pancreatic cancer_Homo sapiens_hsa052121.31121424
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30963978
41Chemokine signaling pathway_Homo sapiens_hsa040621.28789407
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27171571
43Asthma_Homo sapiens_hsa053101.24743139
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24108922
45Platelet activation_Homo sapiens_hsa046111.21649606
46Influenza A_Homo sapiens_hsa051641.21222500
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20864285
48Salmonella infection_Homo sapiens_hsa051321.19146074
49Other glycan degradation_Homo sapiens_hsa005111.10960657
50Small cell lung cancer_Homo sapiens_hsa052221.10459804
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08889008
52HTLV-I infection_Homo sapiens_hsa051661.08683392
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.08265317
54VEGF signaling pathway_Homo sapiens_hsa043701.01470977
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98645724
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.98593844
57Colorectal cancer_Homo sapiens_hsa052100.98436415
58Epstein-Barr virus infection_Homo sapiens_hsa051690.96454749
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94770807
60Viral carcinogenesis_Homo sapiens_hsa052030.94574813
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92397208
62p53 signaling pathway_Homo sapiens_hsa041150.91404582
63Proteoglycans in cancer_Homo sapiens_hsa052050.88694454
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88330768
65Notch signaling pathway_Homo sapiens_hsa043300.88246471
66Focal adhesion_Homo sapiens_hsa045100.88149860
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87632437
68Autoimmune thyroid disease_Homo sapiens_hsa053200.86355404
69Non-small cell lung cancer_Homo sapiens_hsa052230.84332996
70MicroRNAs in cancer_Homo sapiens_hsa052060.83933432
71Lysosome_Homo sapiens_hsa041420.81914540
72Amoebiasis_Homo sapiens_hsa051460.78801058
73Adherens junction_Homo sapiens_hsa045200.75420075
74Hepatitis C_Homo sapiens_hsa051600.74775218
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72410812
76Ribosome_Homo sapiens_hsa030100.71562037
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.71072225
78Prolactin signaling pathway_Homo sapiens_hsa049170.69232814
79Base excision repair_Homo sapiens_hsa034100.68341764
80DNA replication_Homo sapiens_hsa030300.68083297
81Endocytosis_Homo sapiens_hsa041440.66778747
82HIF-1 signaling pathway_Homo sapiens_hsa040660.65761312
83Prion diseases_Homo sapiens_hsa050200.62374629
84Phagosome_Homo sapiens_hsa041450.58412927
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57529528
86Renal cell carcinoma_Homo sapiens_hsa052110.57088662
87GnRH signaling pathway_Homo sapiens_hsa049120.56425299
88mTOR signaling pathway_Homo sapiens_hsa041500.56153470
89Pathways in cancer_Homo sapiens_hsa052000.55563119
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53688270
91Spliceosome_Homo sapiens_hsa030400.53071415
92FoxO signaling pathway_Homo sapiens_hsa040680.52484461
93Rheumatoid arthritis_Homo sapiens_hsa053230.51908731
94Dorso-ventral axis formation_Homo sapiens_hsa043200.51573515
95Rap1 signaling pathway_Homo sapiens_hsa040150.50780927
96Bladder cancer_Homo sapiens_hsa052190.49142005
97Insulin resistance_Homo sapiens_hsa049310.49071564
98ErbB signaling pathway_Homo sapiens_hsa040120.48765592
99Prostate cancer_Homo sapiens_hsa052150.48302305
100ECM-receptor interaction_Homo sapiens_hsa045120.48194219
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.47548337
102Cell cycle_Homo sapiens_hsa041100.46375510
103Endometrial cancer_Homo sapiens_hsa052130.45823836
104Choline metabolism in cancer_Homo sapiens_hsa052310.43824660
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43183638
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.41834121
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40768464
108MAPK signaling pathway_Homo sapiens_hsa040100.40424042
109Glioma_Homo sapiens_hsa052140.39976811
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39846842
111Type II diabetes mellitus_Homo sapiens_hsa049300.38887008
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36949030
113African trypanosomiasis_Homo sapiens_hsa051430.36736894
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32998981
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.30936856

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