PPP1R16A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.20898214
2proline metabolic process (GO:0006560)7.36883796
3phosphorelay signal transduction system (GO:0000160)6.68624973
4modulation by virus of host process (GO:0019054)5.87896546
5negative regulation of catenin import into nucleus (GO:0035414)5.56794153
6detection of calcium ion (GO:0005513)5.25298392
7cellular response to virus (GO:0098586)5.18145691
8DNA deamination (GO:0045006)5.17748831
9axonemal dynein complex assembly (GO:0070286)4.97185966
10sulfur amino acid catabolic process (GO:0000098)4.91549820
11negative regulation of Ras GTPase activity (GO:0034261)4.88268235
12modulation by symbiont of host cellular process (GO:0044068)4.83956458
13glutamine family amino acid biosynthetic process (GO:0009084)4.76221247
14motile cilium assembly (GO:0044458)4.57864979
15endothelial tube morphogenesis (GO:0061154)4.36877212
16morphogenesis of an endothelium (GO:0003159)4.36877212
17transcription from mitochondrial promoter (GO:0006390)4.34732751
18neuromuscular process controlling posture (GO:0050884)4.25421760
19NADH metabolic process (GO:0006734)4.24263072
20glutathione biosynthetic process (GO:0006750)4.22944191
21desmosome organization (GO:0002934)4.21582160
22establishment of apical/basal cell polarity (GO:0035089)4.13338452
23negative regulation of protein oligomerization (GO:0032460)4.12372116
24regulation of protein homooligomerization (GO:0032462)4.06782898
25protein insertion into membrane (GO:0051205)4.06261133
26regulation of integrin activation (GO:0033623)4.04558931
27vitamin transmembrane transport (GO:0035461)3.97311776
28semaphorin-plexin signaling pathway (GO:0071526)3.94783605
29nonribosomal peptide biosynthetic process (GO:0019184)3.89596695
30establishment of monopolar cell polarity (GO:0061162)3.89357449
31establishment or maintenance of monopolar cell polarity (GO:0061339)3.89357449
32negative regulation of cell size (GO:0045792)3.85708422
33signal complex assembly (GO:0007172)3.81166223
34embryonic process involved in female pregnancy (GO:0060136)3.73382910
35modulation by virus of host morphology or physiology (GO:0019048)3.72540453
36lung epithelium development (GO:0060428)3.70945404
37Golgi transport vesicle coating (GO:0048200)3.67606709
38COPI coating of Golgi vesicle (GO:0048205)3.67606709
39calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.65311879
40GDP-mannose metabolic process (GO:0019673)3.64229560
41venous blood vessel morphogenesis (GO:0048845)3.64045781
42layer formation in cerebral cortex (GO:0021819)3.63657288
43primary alcohol catabolic process (GO:0034310)3.61680575
44ethanol metabolic process (GO:0006067)3.58320103
45urea cycle (GO:0000050)3.55506070
46cell-cell junction maintenance (GO:0045217)3.55390198
47positive regulation of protein homooligomerization (GO:0032464)3.53141773
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49737718
49activation of Rac GTPase activity (GO:0032863)3.46570196
50regulation of cholesterol biosynthetic process (GO:0045540)3.45757251
51regulation of early endosome to late endosome transport (GO:2000641)3.42887553
52urea metabolic process (GO:0019627)3.42702255
53cellular response to glucagon stimulus (GO:0071377)3.42328870
54regulation of cholesterol metabolic process (GO:0090181)3.40743628
55positive regulation of synapse maturation (GO:0090129)3.40372060
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.35139102
57planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34547352
58embryonic camera-type eye development (GO:0031076)3.34088989
59cilium or flagellum-dependent cell motility (GO:0001539)3.33157212
60adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.31744908
61negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.26792059
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25610527
63negative regulation of fatty acid biosynthetic process (GO:0045717)3.24694480
64mitochondrial DNA metabolic process (GO:0032042)3.24411829
65oxidative demethylation (GO:0070989)3.23255819
66endothelial cell chemotaxis (GO:0035767)3.17122536
67intestinal cholesterol absorption (GO:0030299)3.16847807
68epithelial cell-cell adhesion (GO:0090136)3.13684298
69regulation of fatty acid beta-oxidation (GO:0031998)3.12658065
70regulation of podosome assembly (GO:0071801)3.11334382
71regulation of cholesterol homeostasis (GO:2000188)3.11189825
72ADP metabolic process (GO:0046031)3.08430830
73fructose metabolic process (GO:0006000)3.06934156
74nerve growth factor signaling pathway (GO:0038180)3.06839406
75negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05783328
76L-phenylalanine metabolic process (GO:0006558)3.04218969
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.04218969
78nitrogen cycle metabolic process (GO:0071941)3.04212095
79response to glucagon (GO:0033762)3.03899917
80negative regulation of JAK-STAT cascade (GO:0046426)3.03128268
81epoxygenase P450 pathway (GO:0019373)3.01158977
82ethanol oxidation (GO:0006069)3.00289200
83positive regulation of Cdc42 GTPase activity (GO:0043089)3.00039314
84regulation of cilium movement (GO:0003352)2.99239652
85mannose metabolic process (GO:0006013)2.99085134
86regulation of ARF GTPase activity (GO:0032312)2.97061588
87regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95375795
88establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.94650738
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.91984970
90regulation of telomere maintenance via telomerase (GO:0032210)2.91711878
91embryonic placenta development (GO:0001892)2.91607500
92negative regulation of anoikis (GO:2000811)2.91363760
93regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90708805
94cell junction maintenance (GO:0034331)2.90005119
95negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.89757895
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.87243896
97regulation of G0 to G1 transition (GO:0070316)2.86726392
98histone H4-K12 acetylation (GO:0043983)2.85647993
99multicellular organismal water homeostasis (GO:0050891)2.85478955
100spinal cord development (GO:0021510)2.84911517
101maternal placenta development (GO:0001893)2.84225110
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.80834382
103establishment or maintenance of apical/basal cell polarity (GO:0035088)2.80228418
104establishment or maintenance of bipolar cell polarity (GO:0061245)2.80228418
105amyloid precursor protein catabolic process (GO:0042987)2.80014563
106positive regulation by host of viral transcription (GO:0043923)2.76727287
107regulation of hydrogen peroxide metabolic process (GO:0010310)2.76208157
108positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.76077813
109cilium movement (GO:0003341)2.73271265
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.73260259
111positive regulation of fatty acid beta-oxidation (GO:0032000)2.72999516
112mitotic G1 DNA damage checkpoint (GO:0031571)2.72591758
113angiotensin maturation (GO:0002003)2.71972150
114cellular modified amino acid catabolic process (GO:0042219)2.71850164
115positive regulation of triglyceride lipase activity (GO:0061365)2.71790783
116positive regulation of lipoprotein lipase activity (GO:0051006)2.71790783
117very-low-density lipoprotein particle assembly (GO:0034379)2.71226926
118regulation of glucose import in response to insulin stimulus (GO:2001273)2.70977660
119negative regulation of GTPase activity (GO:0034260)2.68982762
120negative regulation of GTP catabolic process (GO:0033125)2.68982762
121glyoxylate metabolic process (GO:0046487)2.68068580
122peptide biosynthetic process (GO:0043043)2.67317274
123cellular response to ATP (GO:0071318)2.64094674
124regulation of protein oligomerization (GO:0032459)2.62424414
125cell volume homeostasis (GO:0006884)2.62001390
126release of cytochrome c from mitochondria (GO:0001836)2.60670527
127positive regulation of lipid catabolic process (GO:0050996)2.60070256
128negative regulation of fatty acid transport (GO:2000192)2.59821222
129regulation of anoikis (GO:2000209)2.59688928
130positive regulation of triglyceride metabolic process (GO:0090208)2.59587945
131adherens junction assembly (GO:0034333)2.58700504
132cysteine metabolic process (GO:0006534)2.58462090
133ear development (GO:0043583)2.56780942
134glucose 6-phosphate metabolic process (GO:0051156)2.56094448
135protein localization to endosome (GO:0036010)2.55669060
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55170064
137L-phenylalanine catabolic process (GO:0006559)2.55170064
138cellular response to prostaglandin stimulus (GO:0071379)2.54615367
139regulation of p38MAPK cascade (GO:1900744)2.54493832
140alkaloid metabolic process (GO:0009820)2.54486644
141diacylglycerol metabolic process (GO:0046339)2.54435727
142regulation of extracellular matrix disassembly (GO:0010715)2.54357731
143acetyl-CoA metabolic process (GO:0006084)2.53281086
144cell-substrate adherens junction assembly (GO:0007045)2.52729107
145focal adhesion assembly (GO:0048041)2.52729107
146apoptotic process involved in morphogenesis (GO:0060561)2.52621418
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.52282897
148left/right pattern formation (GO:0060972)2.51029047
149fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50040279
150neuronal action potential (GO:0019228)2.49036906
151protein retention in ER lumen (GO:0006621)2.48825535
152atrioventricular valve morphogenesis (GO:0003181)2.47083013
153mitotic G1/S transition checkpoint (GO:0044819)2.46506452
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45236548
155drug metabolic process (GO:0017144)2.44403867
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43834760
157positive regulation of receptor recycling (GO:0001921)2.43387117
158renal system process involved in regulation of blood volume (GO:0001977)2.43227664
159stress fiber assembly (GO:0043149)2.43140424
160hemidesmosome assembly (GO:0031581)2.43137539
1614-hydroxyproline metabolic process (GO:0019471)2.42975442
162histone H4-K5 acetylation (GO:0043981)2.42860808
163histone H4-K8 acetylation (GO:0043982)2.42860808
164type B pancreatic cell proliferation (GO:0044342)2.42176660
165regulation of microtubule-based movement (GO:0060632)2.41969457
166striated muscle atrophy (GO:0014891)2.41909688
167actin filament depolymerization (GO:0030042)2.41666622
168regulation of hippo signaling (GO:0035330)2.41288506
169protein carboxylation (GO:0018214)2.41149650
170peptidyl-glutamic acid carboxylation (GO:0017187)2.41149650
171amyloid precursor protein metabolic process (GO:0042982)2.40243122
172microtubule bundle formation (GO:0001578)2.39573541
173phospholipid efflux (GO:0033700)2.37590193
174positive regulation of histone deacetylation (GO:0031065)2.37162973
175branching involved in mammary gland duct morphogenesis (GO:0060444)2.36128504
176skeletal muscle adaptation (GO:0043501)2.34506262
177positive regulation of pseudopodium assembly (GO:0031274)2.33927011
178Rho protein signal transduction (GO:0007266)2.32945926
179regulation of cholesterol esterification (GO:0010872)2.32766922
180adhesion of symbiont to host (GO:0044406)2.32537757
181regulation of endothelial cell chemotaxis (GO:2001026)2.31636273
182basement membrane organization (GO:0071711)2.31439416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.22154302
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.20573697
3LXR_22292898_ChIP-Seq_THP-1_Human2.73078404
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61673352
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.58642594
6* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53570592
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.37449667
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36134014
9ZNF263_19887448_ChIP-Seq_K562_Human2.33748943
10* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33508097
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27731639
12KDM2B_26808549_Chip-Seq_K562_Human2.24621911
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.19556632
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17398881
15* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09788351
16RACK7_27058665_Chip-Seq_MCF-7_Human2.05807957
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05164949
18KDM2B_26808549_Chip-Seq_DND41_Human1.96935454
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93497983
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.93180606
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.89444865
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.84097079
23VDR_21846776_ChIP-Seq_THP-1_Human1.78279783
24* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.74637437
25* BCOR_27268052_Chip-Seq_Bcells_Human1.72342399
26MYC_22102868_ChIP-Seq_BL_Human1.71370992
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71191483
28CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.70325950
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68832697
30CTCF_27219007_Chip-Seq_Bcells_Human1.68596486
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66756052
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64267479
33* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59773407
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.59487321
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59058693
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58467576
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57537199
38* P68_20966046_ChIP-Seq_HELA_Human1.55292888
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54691735
40* E2F1_20622854_ChIP-Seq_HELA_Human1.52688517
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51461133
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48786639
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48714487
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47905942
45* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46845992
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46226737
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45881190
48* PHF8_20622854_ChIP-Seq_HELA_Human1.45157552
49* SMC4_20622854_ChIP-Seq_HELA_Human1.42832753
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42484087
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42445133
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41510108
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.39608569
54CREB1_26743006_Chip-Seq_LNCaP_Human1.39015916
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38041737
56TET1_21490601_ChIP-Seq_MESCs_Mouse1.37343153
57RARB_24833708_ChIP-Seq_LIVER_Mouse1.36706848
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35537349
59RARA_24833708_ChIP-Seq_LIVER_Mouse1.35254378
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34234320
61* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33418949
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32193167
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32140631
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.31671622
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31430604
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31388921
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.29935134
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29525617
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27176972
70* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26572069
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.25961394
72* BCL6_27268052_Chip-Seq_Bcells_Human1.25919798
73TP53_22127205_ChIP-Seq_IMR90_Human1.25562285
74* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25468808
75CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25260726
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24853491
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24757763
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.23983894
79ATF3_27146783_Chip-Seq_COLON_Human1.23863318
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23846293
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23245094
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22187856
83DROSHA_22980978_ChIP-Seq_HELA_Human1.21759375
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19958854
85RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19792148
86SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.19496201
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.19133808
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18325596
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18032806
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16692611
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16031349
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.15102161
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.15094231
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.14511450
95CLOCK_20551151_ChIP-Seq_293T_Human1.14450647
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14004303
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14001564
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13882913
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13258409
100* CTCF_20526341_ChIP-Seq_ESCs_Human1.12742220
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12726012
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12539192
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.12458934
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.11797781
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11652453
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11509674
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.11002993
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09706813
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09586062
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08788161
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08788161
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08788161
113STAT1_20625510_ChIP-Seq_HELA_Human1.08444359
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08443163
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05719780
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05628626
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.05306852
118* OCT4_19829295_ChIP-Seq_ESCs_Human1.04883819
119RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04359872
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04178370
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03628615
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03361601
123TCF7_22412390_ChIP-Seq_EML_Mouse1.02860060
124CTCF_21964334_Chip-Seq_Bcells_Human1.02589067
125SA1_27219007_Chip-Seq_Bcells_Human1.02424651
126TP63_22573176_ChIP-Seq_HFKS_Human1.02398127
127FOXP1_21924763_ChIP-Seq_HESCs_Human1.02347847
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02254156
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01336560
130KLF5_25053715_ChIP-Seq_YYC3_Human1.01080774
131NCOR1_26117541_ChIP-Seq_K562_Human1.00563653
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00475014
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00323158
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99107387
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98119435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.92979222
2MP0003878_abnormal_ear_physiology3.92979222
3MP0010234_abnormal_vibrissa_follicle3.89294130
4MP0004233_abnormal_muscle_weight3.65608332
5MP0005365_abnormal_bile_salt3.51464537
6MP0003283_abnormal_digestive_organ3.38542038
7MP0005085_abnormal_gallbladder_physiolo3.32093771
8MP0005360_urolithiasis3.24577729
9MP0002139_abnormal_hepatobiliary_system3.20691761
10MP0000566_synostosis3.09524765
11MP0010030_abnormal_orbit_morphology3.09085182
12MP0000678_abnormal_parathyroid_gland3.07424535
13MP0004858_abnormal_nervous_system3.03362085
14MP0002653_abnormal_ependyma_morphology3.01423758
15MP0010352_gastrointestinal_tract_polyps2.78025092
16MP0005409_darkened_coat_color2.68248736
17MP0004859_abnormal_synaptic_plasticity2.64072896
18MP0005451_abnormal_body_composition2.51725305
19MP0001849_ear_inflammation2.45919640
20MP0003806_abnormal_nucleotide_metabolis2.33790378
21MP0004264_abnormal_extraembryonic_tissu2.28911178
22MP0005171_absent_coat_pigmentation2.17834401
23MP0003252_abnormal_bile_duct2.08081922
24MP0009278_abnormal_bone_marrow2.01877929
25MP0005670_abnormal_white_adipose1.99640829
26MP0001984_abnormal_olfaction1.91679912
27MP0000015_abnormal_ear_pigmentation1.87977251
28MP0009780_abnormal_chondrocyte_physiolo1.86438296
29MP0008875_abnormal_xenobiotic_pharmacok1.85193571
30MP0009840_abnormal_foam_cell1.73821801
31MP0000537_abnormal_urethra_morphology1.72255404
32MP0005645_abnormal_hypothalamus_physiol1.69014415
33MP0005666_abnormal_adipose_tissue1.68248903
34MP0003453_abnormal_keratinocyte_physiol1.60638548
35MP0000639_abnormal_adrenal_gland1.60202689
36MP0004185_abnormal_adipocyte_glucose1.58156435
37MP0002269_muscular_atrophy1.51812642
38MP0004270_analgesia1.51373064
39MP0009379_abnormal_foot_pigmentation1.50215207
40MP0002098_abnormal_vibrissa_morphology1.48657665
41MP0005501_abnormal_skin_physiology1.45395047
42MP0001664_abnormal_digestion1.44473119
43MP0000003_abnormal_adipose_tissue1.43287305
44MP0005332_abnormal_amino_acid1.42126661
45MP0008260_abnormal_autophagy1.39543606
46MP0008995_early_reproductive_senescence1.39211161
47MP0003172_abnormal_lysosome_physiology1.38653856
48MP0003879_abnormal_hair_cell1.36039405
49MP0010329_abnormal_lipoprotein_level1.35906952
50MP0005083_abnormal_biliary_tract1.35897570
51MP0004133_heterotaxia1.34788778
52MP0000467_abnormal_esophagus_morphology1.32454881
53MP0001666_abnormal_nutrient_absorption1.30435036
54MP0000751_myopathy1.27689595
55MP0003119_abnormal_digestive_system1.27399573
56MP0000371_diluted_coat_color1.26806945
57MP0003705_abnormal_hypodermis_morpholog1.26223265
58MP0003183_abnormal_peptide_metabolism1.25329775
59MP0009384_cardiac_valve_regurgitation1.25053593
60MP0009643_abnormal_urine_homeostasis1.23028944
61MP0001485_abnormal_pinna_reflex1.21185626
62MP0006138_congestive_heart_failure1.20683405
63MP0001765_abnormal_ion_homeostasis1.20573325
64MP0001873_stomach_inflammation1.20530052
65MP0004019_abnormal_vitamin_homeostasis1.19766647
66MP0004043_abnormal_pH_regulation1.19039134
67MP0000747_muscle_weakness1.18915792
68MP0005076_abnormal_cell_differentiation1.16697680
69MP0000681_abnormal_thyroid_gland1.16427529
70MP0002118_abnormal_lipid_homeostasis1.15161010
71MP0005623_abnormal_meninges_morphology1.13304745
72MP0002796_impaired_skin_barrier1.11425239
73MP0002249_abnormal_larynx_morphology1.10828143
74MP0003635_abnormal_synaptic_transmissio1.09748756
75MP0004130_abnormal_muscle_cell1.08343140
76MP0003656_abnormal_erythrocyte_physiolo1.04280260
77MP0004782_abnormal_surfactant_physiolog1.02605696
78MP0004811_abnormal_neuron_physiology1.01011143
79MP0001502_abnormal_circadian_rhythm1.00786281
80MP0000013_abnormal_adipose_tissue1.00466467
81MP0002063_abnormal_learning/memory/cond0.99074005
82MP0005058_abnormal_lysosome_morphology0.98973154
83MP0000579_abnormal_nail_morphology0.97625169
84MP0003191_abnormal_cellular_cholesterol0.95676228
85MP0002060_abnormal_skin_morphology0.95335024
86MP0005410_abnormal_fertilization0.94950974
87MP0002127_abnormal_cardiovascular_syste0.93829968
88MP0003890_abnormal_embryonic-extraembry0.93795646
89MP0005394_taste/olfaction_phenotype0.93211178
90MP0005499_abnormal_olfactory_system0.93211178
91MP0003566_abnormal_cell_adhesion0.91853978
92MP0000609_abnormal_liver_physiology0.91834763
93MP0003075_altered_response_to0.91141519
94MP0008057_abnormal_DNA_replication0.90898558
95MP0000733_abnormal_muscle_development0.89239947
96MP0000477_abnormal_intestine_morphology0.88589468
97MP0000955_abnormal_spinal_cord0.88404464
98MP0003123_paternal_imprinting0.86982786
99MP0008789_abnormal_olfactory_epithelium0.85920631
100MP0000538_abnormal_urinary_bladder0.85910535
101MP0002896_abnormal_bone_mineralization0.85249919
102MP0008961_abnormal_basal_metabolism0.85175874
103MP0001216_abnormal_epidermal_layer0.84762762
104MP0002572_abnormal_emotion/affect_behav0.84326204
105MP0002132_abnormal_respiratory_system0.84251535
106MP0004381_abnormal_hair_follicle0.83557585
107MP0001348_abnormal_lacrimal_gland0.82454051
108MP0002282_abnormal_trachea_morphology0.82121962
109MP0000462_abnormal_digestive_system0.81252162
110MP0003631_nervous_system_phenotype0.81072146
111MP0010155_abnormal_intestine_physiology0.80564376
112MP0004885_abnormal_endolymph0.79798210
113MP0002822_catalepsy0.78537792
114MP0003329_amyloid_beta_deposits0.78348311
115MP0010678_abnormal_skin_adnexa0.78035104
116MP0002876_abnormal_thyroid_physiology0.77700861
117MP0005330_cardiomyopathy0.76390036
118MP0002152_abnormal_brain_morphology0.76039774
119MP0002064_seizures0.75251755
120MP0001346_abnormal_lacrimal_gland0.74927318
121MP0001340_abnormal_eyelid_morphology0.74336857
122MP0003137_abnormal_impulse_conducting0.73394495
123MP0001186_pigmentation_phenotype0.72375502
124MP0005266_abnormal_metabolism0.72085724
125MP0003045_fibrosis0.71878829
126MP0002970_abnormal_white_adipose0.71780501
127MP0002932_abnormal_joint_morphology0.71773488
128MP0004087_abnormal_muscle_fiber0.71611768
129MP0008874_decreased_physiological_sensi0.71413912
130MP0003633_abnormal_nervous_system0.71243858
131MP0000762_abnormal_tongue_morphology0.70041238
132MP0006072_abnormal_retinal_apoptosis0.69949750
133MP0010771_integument_phenotype0.69785681
134MP0005248_abnormal_Harderian_gland0.69539703
135MP0005375_adipose_tissue_phenotype0.69152427
136MP0009931_abnormal_skin_appearance0.67573008
137MP0000383_abnormal_hair_follicle0.66573797
138MP0002086_abnormal_extraembryonic_tissu0.66546280
139MP0000778_abnormal_nervous_system0.66489260
140MP0002882_abnormal_neuron_morphology0.66329483
141MP0000377_abnormal_hair_follicle0.66066830
142MP0010630_abnormal_cardiac_muscle0.65542094
143MP0002089_abnormal_postnatal_growth/wei0.65146699
144MP0002078_abnormal_glucose_homeostasis0.64574821
145MP0005636_abnormal_mineral_homeostasis0.63534546
146MP0003953_abnormal_hormone_level0.63122123
147MP0005381_digestive/alimentary_phenotyp0.63021953
148MP0005174_abnormal_tail_pigmentation0.62567843
149MP0000759_abnormal_skeletal_muscle0.62386684
150MP0002971_abnormal_brown_adipose0.60922312
151MP0003861_abnormal_nervous_system0.59694074
152MP0000749_muscle_degeneration0.59616466
153MP0002085_abnormal_embryonic_tissue0.59371497
154MP0005023_abnormal_wound_healing0.59309900
155MP0005319_abnormal_enzyme/_coenzyme0.59026748
156MP0000534_abnormal_ureter_morphology0.58750569
157MP0002136_abnormal_kidney_physiology0.58213090
158MP0003638_abnormal_response/metabolism_0.57670209
159MP0000750_abnormal_muscle_regeneration0.57424328
160MP0001764_abnormal_homeostasis0.56180884

Predicted human phenotypes

RankGene SetZ-score
1Turricephaly (HP:0000262)4.90142228
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56240972
3Abnormality of the lower motor neuron (HP:0002366)4.15336179
4Annular pancreas (HP:0001734)4.12558974
5Stridor (HP:0010307)4.07168878
6Nasal polyposis (HP:0100582)3.78567637
7Cerebral aneurysm (HP:0004944)3.68358258
8Abnormal respiratory motile cilium physiology (HP:0012261)3.56523285
9Distal lower limb muscle weakness (HP:0009053)3.53549449
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.48722261
11Absent/shortened dynein arms (HP:0200106)3.48722261
12Flat acetabular roof (HP:0003180)3.43398758
13Abnormality of the nasal mucosa (HP:0000433)3.42182602
14J-shaped sella turcica (HP:0002680)3.41370359
15Abnormal ciliary motility (HP:0012262)3.39631999
16Rib fusion (HP:0000902)3.37887188
17Ulnar bowing (HP:0003031)3.35213542
18Cervical subluxation (HP:0003308)3.25826293
19Ketoacidosis (HP:0001993)3.23254075
20Thin bony cortex (HP:0002753)3.21699491
21Pustule (HP:0200039)3.21066537
22Myokymia (HP:0002411)3.20463164
23Rhinitis (HP:0012384)3.17519813
24Broad face (HP:0000283)3.06271230
25Myoglobinuria (HP:0002913)3.05248268
26Hemorrhage of the eye (HP:0011885)3.04830415
27Male infertility (HP:0003251)2.99481428
28Malnutrition (HP:0004395)2.97780199
29Atelectasis (HP:0100750)2.97350266
30Alopecia of scalp (HP:0002293)2.95535485
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95091750
32Myopathic facies (HP:0002058)2.88336179
33Coronal craniosynostosis (HP:0004440)2.81971739
34Ketosis (HP:0001946)2.80775621
35Gout (HP:0001997)2.79944996
36Mildly elevated creatine phosphokinase (HP:0008180)2.79457568
37Vaginal fistula (HP:0004320)2.79348452
38Polygenic inheritance (HP:0010982)2.78420312
39Large for gestational age (HP:0001520)2.77210158
40Polycythemia (HP:0001901)2.76552308
41Distal lower limb amyotrophy (HP:0008944)2.70819593
42Concave nail (HP:0001598)2.70508806
43Urinary glycosaminoglycan excretion (HP:0003541)2.69866896
44Mucopolysacchariduria (HP:0008155)2.69866896
45Chronic bronchitis (HP:0004469)2.69526791
46Hypochromic microcytic anemia (HP:0004840)2.63548761
47Exercise-induced myalgia (HP:0003738)2.63150766
48Growth hormone excess (HP:0000845)2.57470030
49Congenital hip dislocation (HP:0001374)2.51966805
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51206589
51Abnormality of polysaccharide metabolism (HP:0011012)2.51206589
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51206589
53Late onset (HP:0003584)2.49862108
54Bell-shaped thorax (HP:0001591)2.48924575
55Pancreatic islet-cell hyperplasia (HP:0004510)2.48713156
56Insomnia (HP:0100785)2.47989137
57Hand muscle atrophy (HP:0009130)2.47401804
58Increased connective tissue (HP:0009025)2.46985654
59Narrow nasal bridge (HP:0000446)2.46691249
60Deep venous thrombosis (HP:0002625)2.44483060
61Lymphangioma (HP:0100764)2.42245645
62Abdominal distention (HP:0003270)2.41353048
63Rectal fistula (HP:0100590)2.40476414
64Rectovaginal fistula (HP:0000143)2.40476414
65Bulbar palsy (HP:0001283)2.39121513
66Bowed forearm bones (HP:0003956)2.36041940
67Bowing of the arm (HP:0006488)2.36041940
68Flattened epiphyses (HP:0003071)2.35657007
69Stroke (HP:0001297)2.35567957
70Alacrima (HP:0000522)2.30883201
71Orthostatic hypotension (HP:0001278)2.29471474
72Dysautonomia (HP:0002459)2.28812810
73Dysostosis multiplex (HP:0000943)2.27868807
74Xanthomatosis (HP:0000991)2.27845986
75Abnormality of the distal phalanges of the toes (HP:0010182)2.26719233
76Short nail (HP:0001799)2.26404199
77Poikiloderma (HP:0001029)2.26269506
78Hydroxyprolinuria (HP:0003080)2.26193553
79Abnormality of proline metabolism (HP:0010907)2.26193553
80Hypercortisolism (HP:0001578)2.25855939
81Diaphragmatic weakness (HP:0009113)2.25217565
82Abnormality of the diencephalon (HP:0010662)2.23377308
83Difficulty climbing stairs (HP:0003551)2.21974997
84Choanal stenosis (HP:0000452)2.20900696
85Intestinal fistula (HP:0100819)2.20110574
86Facial hemangioma (HP:0000329)2.19116940
87Achilles tendon contracture (HP:0001771)2.16924717
88Bronchomalacia (HP:0002780)2.16727275
89Hypobetalipoproteinemia (HP:0003563)2.15904872
90Intrahepatic cholestasis (HP:0001406)2.15814271
91Short chin (HP:0000331)2.15748522
92Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15241207
93Progressive muscle weakness (HP:0003323)2.14360353
94Abnormality of the aortic arch (HP:0012303)2.13313143
95Asymmetric septal hypertrophy (HP:0001670)2.12654836
96Hyperactive renin-angiotensin system (HP:0000841)2.12281806
97Abnormality of the periventricular white matter (HP:0002518)2.10872784
98Nuclear cataract (HP:0100018)2.09996492
99Renovascular hypertension (HP:0100817)2.09945004
100Bronchiectasis (HP:0002110)2.09935422
101Hyperammonemia (HP:0001987)2.09806070
102Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.09148343
103Vertebral hypoplasia (HP:0008417)2.09148343
104Clumsiness (HP:0002312)2.05967702
105Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.04276709
106Hyperacusis (HP:0010780)2.04167409
107Elfin facies (HP:0004428)2.03258428
108Hyperparathyroidism (HP:0000843)2.02620965
109Abnormality of endocrine pancreas physiology (HP:0012093)2.01873046
110Abnormality of the pancreatic islet cells (HP:0006476)2.01873046
111Multiple enchondromatosis (HP:0005701)2.01730510
112Right ventricular cardiomyopathy (HP:0011663)2.01312102
113Pili torti (HP:0003777)1.99885627
114Generalized hyperpigmentation (HP:0007440)1.99624493
115Spinal cord compression (HP:0002176)1.98311849
116Abnormal hair laboratory examination (HP:0003328)1.97661254
117Easy fatigability (HP:0003388)1.97212330
118Back pain (HP:0003418)1.96406820
119Increased CSF protein (HP:0002922)1.95391632
120Abnormality of the thoracic spine (HP:0100711)1.94590836
121Testicular atrophy (HP:0000029)1.93793068
122Ankle clonus (HP:0011448)1.93561878
123Bundle branch block (HP:0011710)1.92759448
124Hyperglycinuria (HP:0003108)1.92449804
125Abdominal situs inversus (HP:0003363)1.92371339
126Abnormality of abdominal situs (HP:0011620)1.92371339
127Increased IgM level (HP:0003496)1.90705500
128Abnormality of the Achilles tendon (HP:0005109)1.88806202
129Infertility (HP:0000789)1.87690516
130Premature skin wrinkling (HP:0100678)1.87024491
131Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86174141
132Postural instability (HP:0002172)1.85931224
133Obstructive sleep apnea (HP:0002870)1.84465773
134Short humerus (HP:0005792)1.84099581
135Upper limb amyotrophy (HP:0009129)1.83397385
136Distal upper limb amyotrophy (HP:0007149)1.83397385
137Gastrointestinal dysmotility (HP:0002579)1.82449676
138Reticulocytosis (HP:0001923)1.81709889
139Megalencephaly (HP:0001355)1.81624897
140Protuberant abdomen (HP:0001538)1.79947366
141Sudden death (HP:0001699)1.79393729
142Decreased lacrimation (HP:0000633)1.78530194
143Amyloidosis (HP:0011034)1.78515848
144Lower limb hyperreflexia (HP:0002395)1.77675058
145Metaphyseal cupping (HP:0003021)1.77557412
146Hypotension (HP:0002615)1.77203145
147Joint stiffness (HP:0001387)1.77008693
148Renal duplication (HP:0000075)1.76291516
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.75517258
150Abnormal respiratory epithelium morphology (HP:0012253)1.74615196
151Abnormal respiratory motile cilium morphology (HP:0005938)1.74615196
152Neonatal onset (HP:0003623)1.73706743
153Visual hallucinations (HP:0002367)1.73319579
154Deformed sella turcica (HP:0002681)1.72271440
155Acanthosis nigricans (HP:0000956)1.71552638
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.71343039
157Colitis (HP:0002583)1.71180545
158Broad distal phalanx of finger (HP:0009836)1.70475461
159Hyperthyroidism (HP:0000836)1.69360905
160Fragile skin (HP:0001030)1.67326596
161Hypophosphatemia (HP:0002148)1.67084559
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65451195
163Absent epiphyses (HP:0010577)1.65451195
164Axonal loss (HP:0003447)1.64655264
165Multiple lipomas (HP:0001012)1.63985049
166Thoracic kyphosis (HP:0002942)1.63841653
167Abnormal atrioventricular conduction (HP:0005150)1.63583998
168Down-sloping shoulders (HP:0200021)1.63329174
169Congenital glaucoma (HP:0001087)1.63061130
170Abnormality of complement system (HP:0005339)1.62245642
171Spinal rigidity (HP:0003306)1.62052237
172Occipital encephalocele (HP:0002085)1.60887703
173Focal segmental glomerulosclerosis (HP:0000097)1.57685755
174Long toe (HP:0010511)1.56581370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK15.90366665
2EPHA25.16736631
3ICK4.97617640
4ARAF4.65859051
5DDR24.01475197
6MST1R3.88795283
7PIM23.54955052
8MAPK153.25253974
9MAP3K113.06112833
10TYRO32.95523554
11SMG12.85737373
12PRKD32.38200040
13MATK2.16732216
14TRIB32.16729811
15EEF2K2.15383767
16IRAK32.01260168
17MAP3K61.99388930
18TAOK11.98719070
19FGR1.97861004
20MET1.96524341
21PINK11.95726127
22PDGFRA1.82083853
23NME21.76873274
24UHMK11.72104106
25RAF11.69745405
26MAPKAPK31.68410122
27BRAF1.66162899
28DYRK1B1.55396890
29PRKD21.45737809
30BMX1.44912537
31TTN1.43092469
32TAOK21.35007736
33DAPK11.34307332
34MUSK1.32567503
35MAP3K91.30819114
36CDC42BPA1.25679501
37DMPK1.20768376
38CSK1.17285340
39PHKG21.15470203
40PHKG11.15470203
41MAP2K61.11913418
42BCKDK1.08218213
43PRPF4B1.07924418
44EPHB11.06578755
45PAK41.04951881
46LATS21.04183729
47MARK21.00196976
48NME11.00077783
49GSK3A0.90166424
50MAP3K100.84802751
51RPS6KC10.84634096
52RPS6KL10.84634096
53STK380.82069464
54PRKG20.81000218
55MAPK110.80087222
56ILK0.78107090
57EPHA40.77175150
58TNK20.76635866
59TBK10.76170747
60HIPK20.73747884
61KSR20.70687925
62RPS6KA60.68937533
63PAK60.66087307
64RPS6KB20.65678050
65MAP3K70.64639100
66CAMK2G0.63802458
67RPS6KA10.63535738
68ERN10.63442490
69DAPK20.62253216
70MAP2K30.60014126
71MAP3K30.57871489
72AKT30.57778383
73CAMKK10.57539652
74LRRK20.57400651
75SIK10.57119944
76ERBB20.56869008
77MINK10.55754379
78IRAK20.53009625
79PKN20.51372907
80MAP3K20.50808123
81RET0.49706320
82PRKCH0.49643266
83PRKCI0.47926950
84PRKD10.46775579
85PIM10.44977731
86MTOR0.44209306
87PRKAA10.44000733
88TESK10.43533239
89PRKCZ0.43290367
90NEK60.42898662
91MAPK120.41449348
92CDK60.41097814
93GRK60.40768479
94LIMK10.39564564
95NTRK20.39128359
96NEK10.39086440
97MAP3K10.38374648
98ABL20.38314216
99LMTK20.36449163
100BRSK10.36346298
101CDK120.35500659
102CHUK0.34049992
103PTK20.33769903
104RPS6KA20.33081643
105CAMK2D0.32873868
106AKT20.32623443
107PRKAA20.31533604
108MAP2K40.30085131
109ROCK10.29985969
110CDK50.29666300
111PDK10.29496430
112CDK150.29228044
113EPHB20.28710399
114PTK60.27691040
115NTRK10.27598655
116CAMK2B0.27540287
117MAPK80.27298580
118MARK10.26758064
119SIK30.26756959
120CDK180.26590150
121SIK20.26275833
122GRK50.24842114
123MAPK100.23948912
124CDK11A0.23593206
125WNK40.23342872
126PDGFRB0.23306569
127PLK10.23152279
128PTK2B0.21877727
129CSNK1G10.20925663
130TESK20.20808906
131CDK140.20644559
132MAPK90.20228014
133MAPKAPK20.19692839
134DYRK30.19244579
135YES10.19051272
136ALK0.18261356
137MAP2K20.18094514
138PDPK10.17941314
139PRKACG0.17767919
140FGFR40.17399824
141PDK30.16563584
142PDK40.16563584
143CDK70.13652496

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.48970959
2Nitrogen metabolism_Homo sapiens_hsa009102.81736300
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68639454
4Olfactory transduction_Homo sapiens_hsa047402.49108743
5Histidine metabolism_Homo sapiens_hsa003402.46034452
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33312891
7Arginine biosynthesis_Homo sapiens_hsa002202.32125907
8Other glycan degradation_Homo sapiens_hsa005112.28882538
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.21671500
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12488363
11Pyruvate metabolism_Homo sapiens_hsa006202.10078766
12Fatty acid metabolism_Homo sapiens_hsa012122.00524448
13Tyrosine metabolism_Homo sapiens_hsa003501.85407588
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.80400995
15Galactose metabolism_Homo sapiens_hsa000521.77705827
16Biosynthesis of amino acids_Homo sapiens_hsa012301.75748413
17Arginine and proline metabolism_Homo sapiens_hsa003301.74299554
18GABAergic synapse_Homo sapiens_hsa047271.72306209
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63174318
20Fatty acid degradation_Homo sapiens_hsa000711.62721641
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57103700
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.53615172
23Vitamin digestion and absorption_Homo sapiens_hsa049771.49394890
24Insulin secretion_Homo sapiens_hsa049111.46314942
25Pentose phosphate pathway_Homo sapiens_hsa000301.45715567
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43991432
27Tryptophan metabolism_Homo sapiens_hsa003801.40382689
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34584487
29Bile secretion_Homo sapiens_hsa049761.34579851
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33986139
31Propanoate metabolism_Homo sapiens_hsa006401.33577003
32Circadian entrainment_Homo sapiens_hsa047131.31104793
33Glutathione metabolism_Homo sapiens_hsa004801.29257850
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25627550
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25118068
36VEGF signaling pathway_Homo sapiens_hsa043701.22483086
37Endometrial cancer_Homo sapiens_hsa052131.22140728
38mTOR signaling pathway_Homo sapiens_hsa041501.20483671
39Fat digestion and absorption_Homo sapiens_hsa049751.19587609
40Morphine addiction_Homo sapiens_hsa050321.19456611
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.17715213
42Butanoate metabolism_Homo sapiens_hsa006501.17435299
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15754316
44Tight junction_Homo sapiens_hsa045301.15320890
45Sulfur relay system_Homo sapiens_hsa041221.10674392
46Dopaminergic synapse_Homo sapiens_hsa047281.09928854
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.08114233
48Insulin resistance_Homo sapiens_hsa049311.04362456
49Lysine degradation_Homo sapiens_hsa003101.04356945
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.03730559
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01489212
52Retinol metabolism_Homo sapiens_hsa008301.01068260
53beta-Alanine metabolism_Homo sapiens_hsa004101.00323776
54Renin-angiotensin system_Homo sapiens_hsa046140.99770449
55Bladder cancer_Homo sapiens_hsa052190.99602520
56PPAR signaling pathway_Homo sapiens_hsa033200.99031261
57Glutamatergic synapse_Homo sapiens_hsa047240.98955821
58Insulin signaling pathway_Homo sapiens_hsa049100.98107082
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97589013
60Cholinergic synapse_Homo sapiens_hsa047250.95724616
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93871686
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93343644
63Synaptic vesicle cycle_Homo sapiens_hsa047210.93303753
64Protein digestion and absorption_Homo sapiens_hsa049740.92386489
65Base excision repair_Homo sapiens_hsa034100.91155723
66Hippo signaling pathway_Homo sapiens_hsa043900.89708141
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88231016
68Vitamin B6 metabolism_Homo sapiens_hsa007500.87477564
69Notch signaling pathway_Homo sapiens_hsa043300.87240636
70Fructose and mannose metabolism_Homo sapiens_hsa000510.86780641
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85526601
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.83284485
73Sphingolipid metabolism_Homo sapiens_hsa006000.83143050
74Gap junction_Homo sapiens_hsa045400.82809429
75Colorectal cancer_Homo sapiens_hsa052100.79305794
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78473063
77Sulfur metabolism_Homo sapiens_hsa009200.78086295
78Glycerolipid metabolism_Homo sapiens_hsa005610.76387132
79Linoleic acid metabolism_Homo sapiens_hsa005910.74954867
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.73658267
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72283420
82Carbon metabolism_Homo sapiens_hsa012000.71879494
83Caffeine metabolism_Homo sapiens_hsa002320.71034017
84Chronic myeloid leukemia_Homo sapiens_hsa052200.68757933
85Circadian rhythm_Homo sapiens_hsa047100.68273439
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66504516
87Hedgehog signaling pathway_Homo sapiens_hsa043400.66263992
88Glucagon signaling pathway_Homo sapiens_hsa049220.63667222
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62846234
90Prion diseases_Homo sapiens_hsa050200.62150276
91GnRH signaling pathway_Homo sapiens_hsa049120.61220608
92Collecting duct acid secretion_Homo sapiens_hsa049660.60990811
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60770100
94Hepatitis C_Homo sapiens_hsa051600.60742310
95Arachidonic acid metabolism_Homo sapiens_hsa005900.60241703
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.60173130
97Adherens junction_Homo sapiens_hsa045200.59028437
98ErbB signaling pathway_Homo sapiens_hsa040120.58714630
99Basal cell carcinoma_Homo sapiens_hsa052170.56102533
100Folate biosynthesis_Homo sapiens_hsa007900.54703155
101Choline metabolism in cancer_Homo sapiens_hsa052310.54108086
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54071960
103AMPK signaling pathway_Homo sapiens_hsa041520.54071247
104Vibrio cholerae infection_Homo sapiens_hsa051100.53637836
105Acute myeloid leukemia_Homo sapiens_hsa052210.53366387
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52851923
107Starch and sucrose metabolism_Homo sapiens_hsa005000.52714905
108Complement and coagulation cascades_Homo sapiens_hsa046100.52188384
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50671862
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.49898058
111Phenylalanine metabolism_Homo sapiens_hsa003600.49463803
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48840961
113Oocyte meiosis_Homo sapiens_hsa041140.48746938
114Mineral absorption_Homo sapiens_hsa049780.47854190
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47829269
116Axon guidance_Homo sapiens_hsa043600.47609995
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46413119
118ABC transporters_Homo sapiens_hsa020100.46368471
119Gastric acid secretion_Homo sapiens_hsa049710.46163530
120Selenocompound metabolism_Homo sapiens_hsa004500.46016286
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45658351
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.45356179
123Pancreatic cancer_Homo sapiens_hsa052120.44606440
124Lysosome_Homo sapiens_hsa041420.44577661
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43866665
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.43644705
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42541984
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42044728
129Peroxisome_Homo sapiens_hsa041460.41572383
130Chemical carcinogenesis_Homo sapiens_hsa052040.41175331
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40708777
132Mismatch repair_Homo sapiens_hsa034300.40255651
133Estrogen signaling pathway_Homo sapiens_hsa049150.39330098
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38772117
135Serotonergic synapse_Homo sapiens_hsa047260.38718740
136Melanogenesis_Homo sapiens_hsa049160.38493270
137Dilated cardiomyopathy_Homo sapiens_hsa054140.37994684
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37683472
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.37468553
140Focal adhesion_Homo sapiens_hsa045100.36162386
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35905461
142Inositol phosphate metabolism_Homo sapiens_hsa005620.35686524

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