PPP1R14D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.33242909
2regulation of guanylate cyclase activity (GO:0031282)8.10079082
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.14403082
4aminoglycoside antibiotic metabolic process (GO:0030647)7.00785481
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.56280982
6negative regulation of epidermis development (GO:0045683)6.49988254
7positive regulation of guanylate cyclase activity (GO:0031284)6.36802811
8maintenance of protein location in nucleus (GO:0051457)6.16261595
9somite rostral/caudal axis specification (GO:0032525)6.13857253
10cytidine deamination (GO:0009972)6.00085210
11cytidine metabolic process (GO:0046087)6.00085210
12cytidine catabolic process (GO:0006216)6.00085210
13positive regulation of respiratory burst (GO:0060267)5.96516466
14intestinal epithelial cell development (GO:0060576)5.90150585
15negative regulation of cell cycle G2/M phase transition (GO:1902750)5.89062638
16regulation of mammary gland epithelial cell proliferation (GO:0033599)5.82978854
17regulation of response to osmotic stress (GO:0047484)5.75115770
18regulation of cellular extravasation (GO:0002691)5.63220911
19NADH metabolic process (GO:0006734)5.62979997
20protein localization to kinetochore (GO:0034501)5.53598512
21hormone catabolic process (GO:0042447)5.44707094
22negative regulation of epidermal cell differentiation (GO:0045605)5.44130722
23negative regulation of telomerase activity (GO:0051974)5.36981231
24regulation of nuclear cell cycle DNA replication (GO:0033262)5.30279343
25muscle organ morphogenesis (GO:0048644)5.29160404
26regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.21118227
27endocrine process (GO:0050886)5.21118227
28regulation of systemic arterial blood pressure by hormone (GO:0001990)5.21118227
29vitamin A metabolic process (GO:0006776)5.16605578
30antibacterial humoral response (GO:0019731)5.13213447
31lipoprotein transport (GO:0042953)5.10948211
32fat-soluble vitamin biosynthetic process (GO:0042362)5.07422425
33phenol-containing compound catabolic process (GO:0019336)5.05948377
34regulation of bile acid biosynthetic process (GO:0070857)5.03724976
35regulation of MHC class I biosynthetic process (GO:0045343)4.99097248
36regulation of telomere maintenance via telomerase (GO:0032210)4.98176175
37negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.97769103
38regulation of cGMP biosynthetic process (GO:0030826)4.97092207
39notochord development (GO:0030903)4.95826597
40heterochromatin organization (GO:0070828)4.94352300
41antimicrobial humoral response (GO:0019730)4.94286471
42cellular glucuronidation (GO:0052695)4.93007845
43GDP-mannose metabolic process (GO:0019673)4.92189177
44uronic acid metabolic process (GO:0006063)4.88332640
45glucuronate metabolic process (GO:0019585)4.88332640
46rRNA transcription (GO:0009303)4.85511421
47bile acid and bile salt transport (GO:0015721)4.84802192
48positive regulation of pseudopodium assembly (GO:0031274)4.78304708
49regulation of systemic arterial blood pressure (GO:0003073)4.70659003
50receptor guanylyl cyclase signaling pathway (GO:0007168)4.64783979
51histone H4-K5 acetylation (GO:0043981)4.55756356
52histone H4-K8 acetylation (GO:0043982)4.55756356
53regulation of cilium movement (GO:0003352)4.54325355
54histone H4-K12 acetylation (GO:0043983)4.53924067
55regulation of apoptotic process involved in morphogenesis (GO:1902337)4.52968970
56glomerular filtration (GO:0003094)4.44311050
57nucleoside transmembrane transport (GO:1901642)4.43515871
58mitotic sister chromatid segregation (GO:0000070)4.42876105
59renal system process involved in regulation of blood volume (GO:0001977)4.40992860
60branching involved in mammary gland duct morphogenesis (GO:0060444)4.38287626
61rRNA methylation (GO:0031167)4.34179265
62regulation of pseudopodium assembly (GO:0031272)4.28583321
63regulation of respiratory burst (GO:0060263)4.24644524
64maintenance of gastrointestinal epithelium (GO:0030277)4.23586226
65drug metabolic process (GO:0017144)4.21469035
66regulation of vitamin metabolic process (GO:0030656)4.17552086
67quinone metabolic process (GO:1901661)4.17193863
68regulation of cGMP metabolic process (GO:0030823)4.17089885
69sulfate transmembrane transport (GO:1902358)4.14803011
70rRNA modification (GO:0000154)4.12884293
71pyrimidine ribonucleoside catabolic process (GO:0046133)4.12482002
72protein localization to chromosome, centromeric region (GO:0071459)4.07388527
73transepithelial transport (GO:0070633)4.05671701
74regulation of translation in response to stress (GO:0043555)4.05418181
75oligosaccharide biosynthetic process (GO:0009312)4.05336065
76chromatin assembly (GO:0031497)4.00321416
77renal filtration (GO:0097205)3.98311053
78epoxygenase P450 pathway (GO:0019373)3.97608573
79virion attachment to host cell (GO:0019062)3.97585560
80adhesion of symbiont to host cell (GO:0044650)3.97585560
81diacylglycerol metabolic process (GO:0046339)3.95730343
82fructose metabolic process (GO:0006000)3.93424408
83interferon-gamma production (GO:0032609)3.93254938
84response to dietary excess (GO:0002021)3.91774344
85trophectodermal cell differentiation (GO:0001829)3.91433631
86positive regulation of glycoprotein biosynthetic process (GO:0010560)3.89365636
87calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.89141258
88positive regulation of DNA-dependent DNA replication (GO:2000105)3.88591873
89arginine metabolic process (GO:0006525)3.87913086
90cardiovascular system development (GO:0072358)3.87639167
91digestion (GO:0007586)3.84588292
92primitive streak formation (GO:0090009)3.84509894
93DNA replication checkpoint (GO:0000076)3.83631905
94transcytosis (GO:0045056)3.82648420
95coenzyme catabolic process (GO:0009109)3.79750581
96cell fate commitment involved in formation of primary germ layer (GO:0060795)3.79197119
97urea cycle (GO:0000050)3.77746858
98positive regulation of cGMP biosynthetic process (GO:0030828)3.73812993
99DNA replication-dependent nucleosome assembly (GO:0006335)3.70965840
100DNA replication-dependent nucleosome organization (GO:0034723)3.70965840
101intestinal absorption (GO:0050892)3.67049325
102cellular modified amino acid catabolic process (GO:0042219)3.64729727
103eosinophil chemotaxis (GO:0048245)3.62010888
104sister chromatid segregation (GO:0000819)3.60498339
105negative regulation of telomere maintenance (GO:0032205)3.60004156
106intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.57456195
107urea metabolic process (GO:0019627)3.56868355
108arachidonic acid secretion (GO:0050482)3.56007832
109icosanoid secretion (GO:0032309)3.56007832
110peptide hormone processing (GO:0016486)3.55489256
111ethanol oxidation (GO:0006069)3.55470455
112positive regulation of glycoprotein metabolic process (GO:1903020)3.53713895
113regulation of triglyceride catabolic process (GO:0010896)3.50854773
114nucleoside diphosphate biosynthetic process (GO:0009133)3.50400491
115nucleoside transport (GO:0015858)3.49675307
116very-low-density lipoprotein particle assembly (GO:0034379)3.48561665
117maintenance of protein localization in organelle (GO:0072595)3.47192583
118alkaloid metabolic process (GO:0009820)3.46747644
119phenylpropanoid metabolic process (GO:0009698)3.46520486
120negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.45175730
121signal transduction involved in regulation of gene expression (GO:0023019)3.44774846
122digestive system process (GO:0022600)3.44211875
123glycolipid catabolic process (GO:0019377)3.43181172
124glycosphingolipid catabolic process (GO:0046479)3.40378688
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37340820
126auditory receptor cell differentiation (GO:0042491)3.36841768
127branching involved in labyrinthine layer morphogenesis (GO:0060670)3.34524652
128drug catabolic process (GO:0042737)3.34397792
129sulfate transport (GO:0008272)3.32281271
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.32217045
131primary alcohol catabolic process (GO:0034310)3.31629234
132nitrogen cycle metabolic process (GO:0071941)3.31588051
133O-glycan processing (GO:0016266)3.30280586
134positive regulation of digestive system process (GO:0060456)3.29820215
135regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.29617166
136regulation of telomerase activity (GO:0051972)3.28903575
137adhesion of symbiont to host (GO:0044406)3.27917452
138UDP-N-acetylglucosamine metabolic process (GO:0006047)3.27872876
139transcription from mitochondrial promoter (GO:0006390)3.26578243
140omega-hydroxylase P450 pathway (GO:0097267)3.25970900
141cGMP biosynthetic process (GO:0006182)3.24808983
142complement activation, classical pathway (GO:0006958)3.24730238
143positive regulation of cGMP metabolic process (GO:0030825)3.23947702
144intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.23917253
145vitamin transmembrane transport (GO:0035461)3.22681875
146DNA damage response, detection of DNA damage (GO:0042769)3.22534902
147regulation of cholesterol homeostasis (GO:2000188)3.22077214
148eosinophil migration (GO:0072677)3.21205250
149thyroid hormone metabolic process (GO:0042403)3.21201183
150thyroid hormone generation (GO:0006590)3.20581672
151histone H4-K16 acetylation (GO:0043984)3.20540876
152flavonoid metabolic process (GO:0009812)3.20228604
1533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.19436763
154purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.19436763
155glycosylceramide metabolic process (GO:0006677)3.19319279
156nuclear pore complex assembly (GO:0051292)3.19265180
157antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18909889
158exogenous drug catabolic process (GO:0042738)3.17514077
159mitochondrion distribution (GO:0048311)3.16468906
160positive regulation of fatty acid beta-oxidation (GO:0032000)3.16058541
161cGMP-mediated signaling (GO:0019934)3.15910773
162nucleotide-sugar biosynthetic process (GO:0009226)3.14974018
163modified amino acid transport (GO:0072337)3.13547652
164sphingomyelin metabolic process (GO:0006684)3.12831325
165phosphatidylserine acyl-chain remodeling (GO:0036150)3.12144042
166sulfur amino acid catabolic process (GO:0000098)3.10622842
167hypotonic response (GO:0006971)3.09108761
168fucosylation (GO:0036065)3.09079694
169positive regulation of protein deacetylation (GO:0090312)3.07169105
170cullin deneddylation (GO:0010388)3.07107930
171renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.07001928
172glucocorticoid biosynthetic process (GO:0006704)3.06410971
173antigen processing and presentation of endogenous antigen (GO:0019883)3.06346540
174peptide catabolic process (GO:0043171)3.05938499
175glycerol metabolic process (GO:0006071)3.05023722
176fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03922226
177phosphatidylinositol acyl-chain remodeling (GO:0036149)3.03045611
178bile acid metabolic process (GO:0008206)3.02859402
179drug transmembrane transport (GO:0006855)3.02814954
180actin filament depolymerization (GO:0030042)3.01579415
181pseudouridine synthesis (GO:0001522)2.99366367
182drug transport (GO:0015893)2.99288336
183icosanoid transport (GO:0071715)2.97812408
184fatty acid derivative transport (GO:1901571)2.97812408
185vitamin transport (GO:0051180)2.97344378
186tachykinin receptor signaling pathway (GO:0007217)2.97085690
187plasma lipoprotein particle assembly (GO:0034377)2.96460401
188retinoic acid receptor signaling pathway (GO:0048384)2.95198552
189sulfur compound transport (GO:0072348)2.93609507
190fat-soluble vitamin metabolic process (GO:0006775)2.92941099
191doxorubicin metabolic process (GO:0044598)10.7909318
192daunorubicin metabolic process (GO:0044597)10.7909318
193polyketide metabolic process (GO:0030638)10.7909318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.22448120
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.22448120
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.22448120
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.98998957
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.47056903
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.13165351
7E2F7_22180533_ChIP-Seq_HELA_Human3.49439906
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.28768320
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.27074557
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.12484684
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.11511852
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.04913786
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.91024948
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.90023790
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.82356567
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.80342485
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.73821392
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.70651682
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.61884144
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.60067236
21SOX2_20726797_ChIP-Seq_SW620_Human2.52963054
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.44355418
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.41895418
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.36552023
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.35544890
26* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.28915611
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26634849
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.21036232
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20036510
30* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.16001266
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13914625
32* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.11104339
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.10497970
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.10250770
35LXR_22158963_ChIP-Seq_LIVER_Mouse2.08803179
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08417472
37STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02724669
38CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02446958
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.98362249
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.95678275
41PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.91341947
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90658255
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85523810
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81836386
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80183711
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78940554
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.74763683
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73585867
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69614301
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65214907
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63625229
52* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.63046855
53IRF1_19129219_ChIP-ChIP_H3396_Human1.60990731
54TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.60075355
55POU5F1_16518401_ChIP-PET_MESCs_Mouse1.59975395
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57650935
57* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.55711334
58OCT4_18692474_ChIP-Seq_MEFs_Mouse1.54490283
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.53471993
60POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.51529443
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.50496270
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.49892575
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47136227
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.45971702
65CDX2_22108803_ChIP-Seq_LS180_Human1.43055813
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42880873
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42602903
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38622023
69LXR_22292898_ChIP-Seq_THP-1_Human1.37270979
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.35666920
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34364038
72SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34122366
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.32844880
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31068539
75BCL6_27268052_Chip-Seq_Bcells_Human1.30006269
76FOXA1_25552417_ChIP-Seq_VCAP_Human1.29985305
77PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29624407
78SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28460476
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27516629
80NANOG_20526341_ChIP-Seq_ESCs_Human1.25893582
81SA1_27219007_Chip-Seq_Bcells_Human1.25342602
82CEBPB_22108803_ChIP-Seq_LS180_Human1.25064293
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24348764
84FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21561082
85E2F1_17053090_ChIP-ChIP_MCF-7_Human1.20992263
86STAT1_20625510_ChIP-Seq_HELA_Human1.20766798
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17397955
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17390809
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17096337
90HNF4A_19822575_ChIP-Seq_HepG2_Human1.16686869
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16575881
92* TET1_21451524_ChIP-Seq_MESCs_Mouse1.16268444
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15665686
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14715375
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13332844
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12862913
97GATA6_25053715_ChIP-Seq_YYC3_Human1.11747389
98NANOG_16518401_ChIP-PET_MESCs_Mouse1.11705672
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11567059
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10866587
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10134357
102JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09349021
103EGR1_19032775_ChIP-ChIP_M12_Human1.09056242
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07401144
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05695160
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05605573
107DROSHA_22980978_ChIP-Seq_HELA_Human1.05038689
108RXR_22108803_ChIP-Seq_LS180_Human1.04209712
109CTCF_27219007_Chip-Seq_Bcells_Human1.03790231
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02987749
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02413170
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01202429
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00703347
114BCAT_22108803_ChIP-Seq_LS180_Human0.99292060
115KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98879088
116FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97767393
117EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97756669
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95931083
119E2F1_20622854_ChIP-Seq_HELA_Human0.95722487
120TP53_22127205_ChIP-Seq_IMR90_Human0.95644815
121AR_21909140_ChIP-Seq_LNCAP_Human0.95640575
122RACK7_27058665_Chip-Seq_MCF-7_Human0.94365192
123P53_21459846_ChIP-Seq_SAOS-2_Human0.93917946
124* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93890078
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93805430
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.93317545
127* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92277533
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92265630
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91904349
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.90712478
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.90456478
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89134417
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88673790
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88566123
135KAP1_27257070_Chip-Seq_ESCs_Mouse0.88470655
136* TAF2_19829295_ChIP-Seq_ESCs_Human0.86517462
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85732239
138SOX2_21211035_ChIP-Seq_LN229_Human0.85660125
139TP63_22573176_ChIP-Seq_HFKS_Human0.85314174
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84976810
141* NCOR1_26117541_ChIP-Seq_K562_Human0.84089866
142P300_27268052_Chip-Seq_Bcells_Human0.83618791
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83385342
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83345346
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83219498
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83172175
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82667705
148* GATA2_19941826_ChIP-Seq_K562_Human0.82068078
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81624684
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81118934
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.80978540
152STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80641517
153* GATA4_25053715_ChIP-Seq_YYC3_Human0.80242698
154CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80166568
155KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79925282
156KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79835025
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79773367
158STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79717904
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78193902
160YY1_22570637_ChIP-Seq_MALME-3M_Human0.77975227
161STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77219386
162E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76783711
163* NANOG_16153702_ChIP-ChIP_HESCs_Human0.75671196
164TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75442612
165PHF8_20622854_ChIP-Seq_HELA_Human0.75395776
166ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74964099
167BCOR_27268052_Chip-Seq_Bcells_Human0.72635057
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.71890855
169SMC4_20622854_ChIP-Seq_HELA_Human0.71415661
170ATF3_27146783_Chip-Seq_COLON_Human0.70911629
171ELK1_22589737_ChIP-Seq_MCF10A_Human0.70890806
172BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70573179
173P68_20966046_ChIP-Seq_HELA_Human0.70181475
174PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69501338
175CTCF_21964334_Chip-Seq_Bcells_Human0.68970761
176MYC_22102868_ChIP-Seq_BL_Human0.68786313
177SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.66387688
178ELF1_20517297_ChIP-Seq_JURKAT_Human0.65010395
179TCF7_22412390_ChIP-Seq_EML_Mouse0.64812283
180EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.64729587
181ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.64446467
182KLF5_25053715_ChIP-Seq_YYC3_Human0.64184818
183TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63516495
184ELK3_25401928_ChIP-Seq_HUVEC_Human0.63438547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu5.74840474
2MP0002139_abnormal_hepatobiliary_system5.34463696
3MP0002254_reproductive_system_inflammat4.48812720
4MP0003011_delayed_dark_adaptation4.28523485
5MP0009379_abnormal_foot_pigmentation4.10787605
6MP0006292_abnormal_olfactory_placode3.74635685
7MP0004147_increased_porphyrin_level3.48645564
8MP0005365_abnormal_bile_salt3.36721623
9MP0005499_abnormal_olfactory_system3.11096929
10MP0005394_taste/olfaction_phenotype3.11096929
11MP0003890_abnormal_embryonic-extraembry2.98178975
12MP0004957_abnormal_blastocyst_morpholog2.97000718
13MP0010352_gastrointestinal_tract_polyps2.87271640
14MP0004858_abnormal_nervous_system2.81376193
15MP0009840_abnormal_foam_cell2.68958298
16MP0005075_abnormal_melanosome_morpholog2.60868310
17MP0003705_abnormal_hypodermis_morpholog2.59283960
18MP0003183_abnormal_peptide_metabolism2.45111907
19MP0002277_abnormal_respiratory_mucosa2.45110890
20MP0001664_abnormal_digestion2.44833574
21MP0003283_abnormal_digestive_organ2.40369148
22MP0005257_abnormal_intraocular_pressure2.35020716
23MP0008057_abnormal_DNA_replication2.27561195
24MP0006035_abnormal_mitochondrial_morpho2.23585354
25MP0002332_abnormal_exercise_endurance2.22944282
26MP0003122_maternal_imprinting2.19589581
27MP0000678_abnormal_parathyroid_gland2.19413544
28MP0005360_urolithiasis2.09278891
29MP0002653_abnormal_ependyma_morphology2.01952329
30MP0001873_stomach_inflammation1.98234060
31MP0000490_abnormal_crypts_of1.97176578
32MP0004043_abnormal_pH_regulation1.93352944
33MP0003938_abnormal_ear_development1.88754011
34MP0003868_abnormal_feces_composition1.87887699
35MP0001663_abnormal_digestive_system1.86564016
36MP0001849_ear_inflammation1.82880556
37MP0001765_abnormal_ion_homeostasis1.81790917
38MP0009643_abnormal_urine_homeostasis1.74816277
39MP0003121_genomic_imprinting1.74782668
40MP0005409_darkened_coat_color1.71950602
41MP0010329_abnormal_lipoprotein_level1.69745591
42MP0005166_decreased_susceptibility_to1.66640091
43MP0005332_abnormal_amino_acid1.66422474
44MP0002876_abnormal_thyroid_physiology1.66072321
45MP0002138_abnormal_hepatobiliary_system1.65205647
46MP0001672_abnormal_embryogenesis/_devel1.63206160
47MP0005380_embryogenesis_phenotype1.63206160
48MP0010030_abnormal_orbit_morphology1.60830913
49MP0005381_digestive/alimentary_phenotyp1.57837783
50MP0003315_abnormal_perineum_morphology1.56063277
51MP0000762_abnormal_tongue_morphology1.55384626
52MP0005636_abnormal_mineral_homeostasis1.52816381
53MP0002088_abnormal_embryonic_growth/wei1.49551828
54MP0003984_embryonic_growth_retardation1.47932569
55MP0001764_abnormal_homeostasis1.43674088
56MP0003123_paternal_imprinting1.43102590
57MP0005266_abnormal_metabolism1.42088165
58MP0006082_CNS_inflammation1.38522076
59MP0003724_increased_susceptibility_to1.37264787
60MP0008961_abnormal_basal_metabolism1.30839011
61MP0000350_abnormal_cell_proliferation1.30447398
62MP0002932_abnormal_joint_morphology1.29402891
63MP0002127_abnormal_cardiovascular_syste1.27592195
64MP0002136_abnormal_kidney_physiology1.27538056
65MP0001188_hyperpigmentation1.27471209
66MP0002086_abnormal_extraembryonic_tissu1.26742884
67MP0005670_abnormal_white_adipose1.26314393
68MP0001293_anophthalmia1.23126770
69MP0002132_abnormal_respiratory_system1.18938471
70MP0000477_abnormal_intestine_morphology1.17155579
71MP0000538_abnormal_urinary_bladder1.16241773
72MP0008789_abnormal_olfactory_epithelium1.15209672
73MP0001756_abnormal_urination1.12857991
74MP0001501_abnormal_sleep_pattern1.11732444
75MP0002092_abnormal_eye_morphology1.11142757
76MP0003879_abnormal_hair_cell1.11070091
77MP0002118_abnormal_lipid_homeostasis1.10919535
78MP0002233_abnormal_nose_morphology1.10547376
79MP0001666_abnormal_nutrient_absorption1.09149660
80MP0003119_abnormal_digestive_system1.09038112
81MP0000465_gastrointestinal_hemorrhage1.08941500
82MP0010234_abnormal_vibrissa_follicle1.08737971
83MP0002085_abnormal_embryonic_tissue1.08350299
84MP0003077_abnormal_cell_cycle1.08291341
85MP0008875_abnormal_xenobiotic_pharmacok1.07729608
86MP0000049_abnormal_middle_ear1.07609097
87MP0003806_abnormal_nucleotide_metabolis1.05277904
88MP0003878_abnormal_ear_physiology1.05082006
89MP0005377_hearing/vestibular/ear_phenot1.05082006
90MP0000230_abnormal_systemic_arterial1.02981035
91MP0002098_abnormal_vibrissa_morphology1.02889624
92MP0001845_abnormal_inflammatory_respons1.00358131
93MP0003693_abnormal_embryo_hatching1.00287421
94MP0010155_abnormal_intestine_physiology0.99746744
95MP0000462_abnormal_digestive_system0.98543424
96MP0003718_maternal_effect0.97967015
97MP0001485_abnormal_pinna_reflex0.96907161
98MP0009785_altered_susceptibility_to0.96317411
99MP0002796_impaired_skin_barrier0.95883507
100MP0005248_abnormal_Harderian_gland0.95820737
101MP0008872_abnormal_physiological_respon0.94654921
102MP0002166_altered_tumor_susceptibility0.94390242
103MP0005448_abnormal_energy_balance0.92701590
104MP0001730_embryonic_growth_arrest0.92480923
105MP0000432_abnormal_head_morphology0.91101175
106MP0003111_abnormal_nucleus_morphology0.90009265
107MP0000609_abnormal_liver_physiology0.88787772
108MP0001348_abnormal_lacrimal_gland0.88597798
109MP0002084_abnormal_developmental_patter0.86451130
110MP0005387_immune_system_phenotype0.85598282
111MP0001790_abnormal_immune_system0.85598282
112MP0002114_abnormal_axial_skeleton0.85048329
113MP0002822_catalepsy0.84739903
114MP0002970_abnormal_white_adipose0.84158909
115MP0005584_abnormal_enzyme/coenzyme_acti0.81636865
116MP0003436_decreased_susceptibility_to0.80105048
117MP0000313_abnormal_cell_death0.79594123
118MP0000537_abnormal_urethra_morphology0.79455559
119MP0005025_abnormal_response_to0.78343712
120MP0005451_abnormal_body_composition0.77801523
121MP0003137_abnormal_impulse_conducting0.77262798
122MP0002971_abnormal_brown_adipose0.76104723
123MP0003755_abnormal_palate_morphology0.75515584
124MP0000428_abnormal_craniofacial_morphol0.74941077
125MP0002396_abnormal_hematopoietic_system0.74793068
126MP0005535_abnormal_body_temperature0.74453623
127MP0003787_abnormal_imprinting0.71508320
128MP0005023_abnormal_wound_healing0.71424199
129MP0010678_abnormal_skin_adnexa0.70358454
130MP0003935_abnormal_craniofacial_develop0.69441283
131MP0003329_amyloid_beta_deposits0.68676146
132MP0005319_abnormal_enzyme/_coenzyme0.68564601
133MP0003191_abnormal_cellular_cholesterol0.68342369
134MP0002006_tumorigenesis0.68253303
135MP0008932_abnormal_embryonic_tissue0.67480358
136MP0001697_abnormal_embryo_size0.67334774
137MP0002080_prenatal_lethality0.66974986
138MP0005645_abnormal_hypothalamus_physiol0.66796492
139MP0009642_abnormal_blood_homeostasis0.66732734
140MP0008469_abnormal_protein_level0.66190346
141MP0009764_decreased_sensitivity_to0.66154425
142MP0001835_abnormal_antigen_presentation0.65801057
143MP0008770_decreased_survivor_rate0.65516305
144MP0004197_abnormal_fetal_growth/weight/0.64690232
145MP0003937_abnormal_limbs/digits/tail_de0.64038891
146MP0005085_abnormal_gallbladder_physiolo0.63932933
147MP0002148_abnormal_hypersensitivity_rea0.63677025
148MP0005310_abnormal_salivary_gland0.61905678
149MP0004270_analgesia0.61049630
150MP0009333_abnormal_splenocyte_physiolog0.60462126
151MP0001533_abnormal_skeleton_physiology0.60127713
152MP0005165_increased_susceptibility_to0.60098413
153MP0003866_abnormal_defecation0.58491770
154MP0004782_abnormal_surfactant_physiolog0.58482901
155MP0003252_abnormal_bile_duct0.58312346
156MP0009115_abnormal_fat_cell0.57994965
157MP0000377_abnormal_hair_follicle0.57773109
158MP0004381_abnormal_hair_follicle0.57694792
159MP0005167_abnormal_blood-brain_barrier0.57383880
160MP0005391_vision/eye_phenotype0.57260897
161MP0004019_abnormal_vitamin_homeostasis0.57178050
162MP0004947_skin_inflammation0.57095432
163MP0005501_abnormal_skin_physiology0.56687313
164MP0008004_abnormal_stomach_pH0.56496393
165MP0003953_abnormal_hormone_level0.54802670
166MP0001881_abnormal_mammary_gland0.54127579
167MP0000249_abnormal_blood_vessel0.53608622
168MP0001800_abnormal_humoral_immune0.52699497
169MP0000604_amyloidosis0.52471629
170MP0002896_abnormal_bone_mineralization0.51695118

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.58783278
2Bilateral microphthalmos (HP:0007633)7.17036930
3Hyperactive renin-angiotensin system (HP:0000841)6.41013015
4Decreased circulating renin level (HP:0003351)6.05476804
5Hypochromic microcytic anemia (HP:0004840)5.69821714
6Hydroxyprolinuria (HP:0003080)5.59509509
7Abnormality of proline metabolism (HP:0010907)5.59509509
8Metabolic alkalosis (HP:0200114)5.52830960
9Multiple enchondromatosis (HP:0005701)5.48487327
10Abnormality of renin-angiotensin system (HP:0000847)5.15888169
11Hepatoblastoma (HP:0002884)5.03301394
12Chronic diarrhea (HP:0002028)4.73749664
13Alkalosis (HP:0001948)4.70720263
14Abnormality of the vitamin B12 metabolism (HP:0004341)4.54356278
15Rib fusion (HP:0000902)4.53002101
16Abnormality of vitamin B metabolism (HP:0004340)4.25598736
17Systemic lupus erythematosus (HP:0002725)4.21391681
18Abnormality of the lower motor neuron (HP:0002366)4.20995523
19Ependymoma (HP:0002888)4.05437522
20Fat malabsorption (HP:0002630)3.90854312
21Partial duplication of thumb phalanx (HP:0009944)3.74444824
22Hypobetalipoproteinemia (HP:0003563)3.71277173
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60088345
24Confusion (HP:0001289)3.59226235
25Rhabdomyosarcoma (HP:0002859)3.57817406
26Neoplasm of striated muscle (HP:0009728)3.54166642
27Rectovaginal fistula (HP:0000143)3.52258409
28Rectal fistula (HP:0100590)3.52258409
29Congenital sensorineural hearing impairment (HP:0008527)3.49533643
30Widely patent fontanelles and sutures (HP:0004492)3.48521738
31Trismus (HP:0000211)3.44406621
32Abnormal cartilage morphology (HP:0002763)3.42610845
33Abnormality of vitamin metabolism (HP:0100508)3.35516634
34Abnormality of the phalanges of the hallux (HP:0010057)3.35035736
35Aplasia/hypoplasia of the humerus (HP:0006507)3.34862485
36Abdominal distention (HP:0003270)3.33145265
37Short humerus (HP:0005792)3.33020934
38Glycosuria (HP:0003076)3.32719549
39Abnormality of urine glucose concentration (HP:0011016)3.32719549
40Hyperaldosteronism (HP:0000859)3.31058698
41Testicular atrophy (HP:0000029)3.23770729
42Partial duplication of the phalanx of hand (HP:0009999)3.23675015
43Nephroblastoma (Wilms tumor) (HP:0002667)3.22484759
44Acanthocytosis (HP:0001927)3.22257498
45Aplasia/Hypoplasia of the fovea (HP:0008060)3.20090944
46Hypoplasia of the fovea (HP:0007750)3.20090944
47Abnormality of chloride homeostasis (HP:0011422)3.18667924
48Abnormality of the distal phalanx of the thumb (HP:0009617)3.17622642
49Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16131199
50Malnutrition (HP:0004395)3.15622487
51Intestinal fistula (HP:0100819)3.12503792
52Cheilitis (HP:0100825)3.12280885
53Fused cervical vertebrae (HP:0002949)3.11759650
54Ragged-red muscle fibers (HP:0003200)3.10365010
55Hyperinsulinemic hypoglycemia (HP:0000825)3.09254441
56Vaginal fistula (HP:0004320)3.07286982
57Abnormality of the salivary glands (HP:0010286)3.04502403
58Abnormality of small intestinal villus morphology (HP:0011472)2.98435445
59Villous atrophy (HP:0011473)2.98435445
60Embryonal renal neoplasm (HP:0011794)2.95976338
61Reduced antithrombin III activity (HP:0001976)2.92759825
62Thin bony cortex (HP:0002753)2.92225919
63Hypokalemia (HP:0002900)2.92083790
64Nausea (HP:0002018)2.90378284
65Pigmentary retinal degeneration (HP:0001146)2.86608472
66Chromsome breakage (HP:0040012)2.83463654
67Proximal tubulopathy (HP:0000114)2.82774070
68Right ventricular cardiomyopathy (HP:0011663)2.79539695
69Microretrognathia (HP:0000308)2.79366666
70Astrocytoma (HP:0009592)2.78865887
71Abnormality of the astrocytes (HP:0100707)2.78865887
72Bifid tongue (HP:0010297)2.76083751
73Anomalous pulmonary venous return (HP:0010772)2.75313745
74Flat acetabular roof (HP:0003180)2.74040630
75Shawl scrotum (HP:0000049)2.73785653
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68576091
77Dicarboxylic aciduria (HP:0003215)2.68576091
78Eczematoid dermatitis (HP:0000976)2.68451428
79Xanthomatosis (HP:0000991)2.68270924
80Hyperammonemia (HP:0001987)2.67677947
81Abnormality of glycine metabolism (HP:0010895)2.65305691
82Abnormality of serine family amino acid metabolism (HP:0010894)2.65305691
83Large earlobe (HP:0009748)2.64009436
84Hyperparathyroidism (HP:0000843)2.63726675
85Hemorrhage of the eye (HP:0011885)2.61444068
86Nephrolithiasis (HP:0000787)2.60033844
87Impulsivity (HP:0100710)2.59657291
88Abnormal lung lobation (HP:0002101)2.59520419
89Conjugated hyperbilirubinemia (HP:0002908)2.57749405
90Abnormality of potassium homeostasis (HP:0011042)2.56389573
91Hyperuricemia (HP:0002149)2.54805897
92Increased purine levels (HP:0004368)2.54805897
93Amyotrophic lateral sclerosis (HP:0007354)2.54359700
94Wide cranial sutures (HP:0010537)2.53069189
95Horizontal nystagmus (HP:0000666)2.51725252
96Periauricular skin pits (HP:0100277)2.50475108
97Preauricular pit (HP:0004467)2.50475108
98Intrahepatic cholestasis (HP:0001406)2.44939007
99Glomerulonephritis (HP:0000099)2.44913038
100Ileus (HP:0002595)2.44823137
101Cerebral palsy (HP:0100021)2.43506983
102Progressive muscle weakness (HP:0003323)2.43337485
103Hypochromic anemia (HP:0001931)2.41916029
104Sensory axonal neuropathy (HP:0003390)2.41709536
105Hypophosphatemia (HP:0002148)2.41345357
106Posterior subcapsular cataract (HP:0007787)2.39672249
107Nasolacrimal duct obstruction (HP:0000579)2.37095379
108Megaloblastic anemia (HP:0001889)2.35415239
109Abnormality of the pulmonary veins (HP:0011718)2.35338633
110Metabolic acidosis (HP:0001942)2.35107781
111Hyponatremia (HP:0002902)2.34885132
112Pili torti (HP:0003777)2.33385980
113Combined immunodeficiency (HP:0005387)2.33260572
114Tongue fasciculations (HP:0001308)2.32989828
115Hypotension (HP:0002615)2.31688288
116Abnormality of the fovea (HP:0000493)2.31672766
117Preauricular skin tag (HP:0000384)2.30912931
118Nephritis (HP:0000123)2.29444125
119Focal segmental glomerulosclerosis (HP:0000097)2.29235541
120Enlarged epiphyses (HP:0010580)2.28443385
121Hyperventilation (HP:0002883)2.28106008
122Abnormality of purine metabolism (HP:0004352)2.26020378
123Abnormal urine phosphate concentration (HP:0012599)2.24364313
124Hyperphosphaturia (HP:0003109)2.23353954
125Abnormality of magnesium homeostasis (HP:0004921)2.22699492
126Increased connective tissue (HP:0009025)2.22521969
127Complement deficiency (HP:0004431)2.21697048
128Pancreatitis (HP:0001733)2.21553020
129Mildly elevated creatine phosphokinase (HP:0008180)2.21328473
130Abnormality of the musculature of the hand (HP:0001421)2.20197122
131Tetraplegia (HP:0002445)2.20165846
132Abnormality of nucleobase metabolism (HP:0010932)2.20034159
133Abnormality of complement system (HP:0005339)2.19008559
134Steatorrhea (HP:0002570)2.18601221
1353-Methylglutaconic aciduria (HP:0003535)2.16967712
136Growth hormone excess (HP:0000845)2.16566617
137Hyperphosphatemia (HP:0002905)2.15338460
138Delayed epiphyseal ossification (HP:0002663)2.11384134
139Abnormal tarsal ossification (HP:0008369)2.08852732
140Generalized hypotonia (HP:0001290)2.07239642
141Abnormal hair laboratory examination (HP:0003328)2.07024501
142Muscle fibrillation (HP:0010546)2.07008421
143Abnormality of pyrimidine metabolism (HP:0004353)2.06973317
144Meckel diverticulum (HP:0002245)2.06751982
145Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06292975
146Glioma (HP:0009733)2.06143000
147Dehydration (HP:0001944)2.06080760
148Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05477942
149Protuberant abdomen (HP:0001538)2.05213502
150Renal tubular acidosis (HP:0001947)2.03296919
151Pendular nystagmus (HP:0012043)2.02154706
152Gout (HP:0001997)2.01842599
153Short 5th finger (HP:0009237)1.99749286
154Potter facies (HP:0002009)1.98791843
155Facial shape deformation (HP:0011334)1.98791843
156Abnormality of the pubic bones (HP:0003172)1.97030636
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.96431888
158Difficulty running (HP:0009046)1.96420383
159Skin tags (HP:0010609)1.96067112
160Glossoptosis (HP:0000162)1.95799023
161Hypopigmentation of the fundus (HP:0007894)1.95326550
162Angiofibromas (HP:0010615)1.94776978
163Adenoma sebaceum (HP:0009720)1.94776978
164Aplasia/Hypoplasia of the macula (HP:0008059)1.94578909
165Syncope (HP:0001279)1.94483013
166Abnormal biliary tract morphology (HP:0012440)1.94337190
167Skin pits (HP:0100276)1.94174770
168Flattened epiphyses (HP:0003071)1.93288285
169Micronodular cirrhosis (HP:0001413)1.93242634
170Abnormality of the costochondral junction (HP:0000919)1.92887805
171Adrenal overactivity (HP:0002717)1.92470292
172Abnormal hemoglobin (HP:0011902)1.91514110
173Multifactorial inheritance (HP:0001426)1.91025527
174Hypoplastic scapulae (HP:0000882)1.89635017
175Aplasia/Hypoplasia of the scapulae (HP:0006713)1.89635017
176Abnormality of the ileum (HP:0001549)1.89496577
177Hyperkalemia (HP:0002153)1.89083709
178Symptomatic seizures (HP:0011145)1.88146466
179Duplication of thumb phalanx (HP:0009942)1.87936880
180Premature ovarian failure (HP:0008209)1.87809438
181Hyperglycinuria (HP:0003108)1.87601317
182Hypolipoproteinemia (HP:0010981)1.87427812
183Abnormality of glycolysis (HP:0004366)1.87125126
184Increased serum pyruvate (HP:0003542)1.87125126
185Progressive external ophthalmoplegia (HP:0000590)1.86316165
186Type I transferrin isoform profile (HP:0003642)1.86193267
187Lethargy (HP:0001254)1.85785651
188Spastic tetraparesis (HP:0001285)1.85315166
189Fasciculations (HP:0002380)1.83604473
190Microvesicular hepatic steatosis (HP:0001414)1.83023517
191Abnormality of chromosome segregation (HP:0002916)1.82386338
192Bone cyst (HP:0012062)1.81549926
193Glomerulosclerosis (HP:0000096)1.81517305
194Petechiae (HP:0000967)1.77255426
195Irritability (HP:0000737)1.75071261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.97936365
2ACVR1B7.06917552
3GRK55.14649946
4GRK64.88543216
5ERN14.47505140
6GRK13.44070678
7ADRBK23.06772101
8STK392.91203655
9TTK2.89693835
10CSF1R2.54812450
11OXSR12.52397021
12MATK2.44821276
13TYRO32.43204816
14PRKG22.32780097
15TGFBR22.25746284
16GRK72.13989643
17STK102.13599907
18MAPK72.00015639
19EPHA21.95122271
20PTK61.93997900
21MOS1.84331716
22PDK21.78175006
23WNK11.76828620
24AKT31.60152355
25FGFR41.50977988
26PAK41.47291901
27STK241.46808070
28CDK71.44335820
29MST1R1.43994330
30MAP3K21.38857830
31MAP3K121.35448154
32MST41.33346717
33NTRK11.30810022
34LMTK21.26796979
35CAMK41.25697267
36MAP2K61.25441894
37TNIK1.24179610
38TYK21.18154344
39EPHA31.17877791
40CHEK21.16483425
41MAP3K101.15464165
42MYLK1.12744242
43WNK41.09372790
44PLK11.05066973
45ADRBK10.99669868
46MARK20.98387685
47MAP4K10.97098157
48CASK0.96948861
49TESK10.95418804
50NLK0.92227898
51NME10.88949573
52EPHB10.86276592
53MAP3K70.86248386
54MAP2K40.83674442
55MAP3K10.82130419
56HIPK20.80490267
57CSK0.80132507
58IRAK10.79131683
59MAP2K20.77665544
60NEK20.77007310
61FGFR30.76864777
62PRKCI0.73267870
63AKT20.73082443
64FER0.71761838
65EPHA40.71206054
66PDPK10.68530185
67FRK0.67974404
68RIPK10.67497809
69ALK0.66357507
70ERBB20.65849490
71CDK190.65393859
72CDC42BPA0.64930165
73PRKAA20.62006231
74CAMK2D0.58720514
75CHEK10.57197454
76MET0.56490241
77EIF2AK20.54123806
78ABL20.53910306
79* PRKCA0.53803927
80NUAK10.51895408
81RPS6KB20.51657208
82AURKB0.50633498
83MAPK110.49916925
84PRKCZ0.49880371
85PDK10.48993526
86RIPK40.48228827
87PTK20.47650110
88DYRK1B0.47139460
89IKBKE0.46773375
90TBK10.45461743
91PAK10.45335787
92NEK10.45295489
93SRC0.43652421
94WEE10.43579207
95TESK20.43338104
96LATS20.42385005
97TXK0.40643860
98* PRKACG0.40549156
99TAOK10.40469826
100DDR20.40430735
101PIM10.37694606
102ZAP700.37260466
103MTOR0.36728855
104BUB10.36184474
105MAP3K90.35991197
106MAPK120.35977009
107AURKA0.35605179
108PRKCD0.35235115
109CDK20.34380652
110LYN0.33977838
111DAPK20.33478932
112IGF1R0.33058765
113JAK20.32589737
114PRKCQ0.32468677
115KIT0.31669974
116PIK3CA0.30550778
117CSNK1E0.30327282
118MAPKAPK20.29408283
119MAP3K80.27445225
120CDK40.27379928
121RET0.26400457
122MAP2K10.26398700
123BMX0.26195926
124ITK0.24646135
125IKBKB0.24587837
126KSR20.24583378
127DMPK0.24393862
128CAMK2G0.23880172
129RPS6KA20.23784179
130LATS10.22171250
131CSNK1A10.21749115
132PRKAA10.21535407
133STK380.21171841
134FYN0.20605944
135STK38L0.20574901
136TAOK20.20566923
137PDGFRA0.19101541
138CDC70.18685606
139FGR0.18394351
140SYK0.17936920
141ATM0.17933609
142JAK10.17908973
143EPHB20.17694439
144INSRR0.17675908
145BMPR20.17631354
146STK30.17079763
147INSR0.15451895
148CDK150.13306761
149MAP3K110.13134172
150GSK3B0.13054273
151NME20.12833762
152CDK11A0.12794508
153GSK3A0.11904184
154PRKACB0.11860378
155CDK10.11544826
156MAPK10.11529285
157ICK0.11063826
158PRKACA0.10370617
159MAPK100.10165675
160PBK0.09797304
161CDK180.08736535
162MAPK40.08176976
163MAPK140.08093241
164PRKD20.06913579

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.23311469
2Vitamin B6 metabolism_Homo sapiens_hsa007505.05815798
3Fructose and mannose metabolism_Homo sapiens_hsa000514.73632910
4Galactose metabolism_Homo sapiens_hsa000523.48705645
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05894599
6Arachidonic acid metabolism_Homo sapiens_hsa005902.89225906
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.70003112
8Linoleic acid metabolism_Homo sapiens_hsa005912.63954028
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.61760879
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.60187144
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.49310142
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46477415
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45827960
14Fat digestion and absorption_Homo sapiens_hsa049752.44543153
15Arginine biosynthesis_Homo sapiens_hsa002202.39593375
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93591946
17Renin-angiotensin system_Homo sapiens_hsa046141.80554341
18Mineral absorption_Homo sapiens_hsa049781.77878194
19Folate biosynthesis_Homo sapiens_hsa007901.75284450
20Nitrogen metabolism_Homo sapiens_hsa009101.68926073
21Ribosome_Homo sapiens_hsa030101.61995026
22Asthma_Homo sapiens_hsa053101.59055912
23Sulfur metabolism_Homo sapiens_hsa009201.58825157
24Thyroid cancer_Homo sapiens_hsa052161.49342005
25Fatty acid degradation_Homo sapiens_hsa000711.45749385
26Pentose phosphate pathway_Homo sapiens_hsa000301.41292617
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39960713
28Chemical carcinogenesis_Homo sapiens_hsa052041.37265473
29Sulfur relay system_Homo sapiens_hsa041221.35326446
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32501977
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27138470
32Tryptophan metabolism_Homo sapiens_hsa003801.17859044
33Protein digestion and absorption_Homo sapiens_hsa049741.14868297
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14033404
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09014374
36Ether lipid metabolism_Homo sapiens_hsa005651.08483982
37Allograft rejection_Homo sapiens_hsa053301.02396191
38Pancreatic secretion_Homo sapiens_hsa049721.00840848
39RNA transport_Homo sapiens_hsa030131.00628794
40Other glycan degradation_Homo sapiens_hsa005111.00066221
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.97028319
42Starch and sucrose metabolism_Homo sapiens_hsa005000.96604133
43Autoimmune thyroid disease_Homo sapiens_hsa053200.96122190
44Graft-versus-host disease_Homo sapiens_hsa053320.95479818
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95231404
46Vitamin digestion and absorption_Homo sapiens_hsa049770.95155394
47Glutathione metabolism_Homo sapiens_hsa004800.94736067
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.94437356
49Bile secretion_Homo sapiens_hsa049760.91335485
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90416846
51Carbon metabolism_Homo sapiens_hsa012000.90096686
52Staphylococcus aureus infection_Homo sapiens_hsa051500.88964752
53Fanconi anemia pathway_Homo sapiens_hsa034600.84879840
54Homologous recombination_Homo sapiens_hsa034400.82947386
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82372700
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80618346
57Tight junction_Homo sapiens_hsa045300.80512598
58mTOR signaling pathway_Homo sapiens_hsa041500.78805634
59Type I diabetes mellitus_Homo sapiens_hsa049400.78492846
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73188784
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72124642
62Glycerolipid metabolism_Homo sapiens_hsa005610.72067685
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.68939870
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66861745
65Mismatch repair_Homo sapiens_hsa034300.64128675
66DNA replication_Homo sapiens_hsa030300.62192838
67African trypanosomiasis_Homo sapiens_hsa051430.62142405
68Phenylalanine metabolism_Homo sapiens_hsa003600.62029302
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.61951287
70Inositol phosphate metabolism_Homo sapiens_hsa005620.61842717
71Sphingolipid metabolism_Homo sapiens_hsa006000.61429752
72Peroxisome_Homo sapiens_hsa041460.60919011
73Fatty acid metabolism_Homo sapiens_hsa012120.58455409
74Caffeine metabolism_Homo sapiens_hsa002320.58320768
75Bladder cancer_Homo sapiens_hsa052190.56685146
76Ovarian steroidogenesis_Homo sapiens_hsa049130.56140568
77Retinol metabolism_Homo sapiens_hsa008300.55051913
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52313940
79Cell cycle_Homo sapiens_hsa041100.51211539
80Butanoate metabolism_Homo sapiens_hsa006500.49895739
81Antigen processing and presentation_Homo sapiens_hsa046120.49127245
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48752392
83mRNA surveillance pathway_Homo sapiens_hsa030150.48032239
84Metabolic pathways_Homo sapiens_hsa011000.47998542
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.47061442
86One carbon pool by folate_Homo sapiens_hsa006700.46697101
87PPAR signaling pathway_Homo sapiens_hsa033200.45147542
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.44688225
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.44603335
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44183918
91Choline metabolism in cancer_Homo sapiens_hsa052310.44139551
92Histidine metabolism_Homo sapiens_hsa003400.44127860
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43273096
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43146762
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43042629
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41226629
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.40174790
98Basal cell carcinoma_Homo sapiens_hsa052170.39666742
99p53 signaling pathway_Homo sapiens_hsa041150.38104335
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37248841
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.37236666
102Tyrosine metabolism_Homo sapiens_hsa003500.36623398
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.35538164
104Biosynthesis of amino acids_Homo sapiens_hsa012300.34962859
105Renin secretion_Homo sapiens_hsa049240.34479417
106Pathways in cancer_Homo sapiens_hsa052000.32921992
107Leishmaniasis_Homo sapiens_hsa051400.31347064
108Thyroid hormone synthesis_Homo sapiens_hsa049180.31087834
109Hedgehog signaling pathway_Homo sapiens_hsa043400.30990824
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30928510
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29103627
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29097359
113Fatty acid biosynthesis_Homo sapiens_hsa000610.28902081
114RNA degradation_Homo sapiens_hsa030180.28824365
115Selenocompound metabolism_Homo sapiens_hsa004500.26398780
116Hippo signaling pathway_Homo sapiens_hsa043900.26229454
117Pertussis_Homo sapiens_hsa051330.24763749
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23417479
119Cardiac muscle contraction_Homo sapiens_hsa042600.22520849
120Adherens junction_Homo sapiens_hsa045200.22470317
121Hepatitis C_Homo sapiens_hsa051600.22423291
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21785856
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21420214
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21011336
125Viral myocarditis_Homo sapiens_hsa054160.20715636
126RNA polymerase_Homo sapiens_hsa030200.20462475
127Pyrimidine metabolism_Homo sapiens_hsa002400.19897289
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.19063195
129Rap1 signaling pathway_Homo sapiens_hsa040150.18776509
130Arginine and proline metabolism_Homo sapiens_hsa003300.18688917
131Propanoate metabolism_Homo sapiens_hsa006400.18586377
132MicroRNAs in cancer_Homo sapiens_hsa052060.18140514
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15357586
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.15232488
135Pyruvate metabolism_Homo sapiens_hsa006200.14909364
136Insulin resistance_Homo sapiens_hsa049310.13205714
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.12876949
138ABC transporters_Homo sapiens_hsa020100.11908969
139Insulin secretion_Homo sapiens_hsa049110.11648670
140Fatty acid elongation_Homo sapiens_hsa000620.10482964
141Toxoplasmosis_Homo sapiens_hsa051450.06318249
142Cocaine addiction_Homo sapiens_hsa050300.04531110
143Rheumatoid arthritis_Homo sapiens_hsa053230.03032324
144Hematopoietic cell lineage_Homo sapiens_hsa046400.02671426
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.00672332
146beta-Alanine metabolism_Homo sapiens_hsa00410-0.0332951
147Tuberculosis_Homo sapiens_hsa05152-0.0308931
148Chemokine signaling pathway_Homo sapiens_hsa04062-0.0071070

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »