PPP1R14BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.96504156
2translational termination (GO:0006415)7.63434938
3ribosomal small subunit assembly (GO:0000028)7.53113735
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.77928751
5cotranslational protein targeting to membrane (GO:0006613)6.65753822
6protein targeting to ER (GO:0045047)6.55435606
7establishment of protein localization to endoplasmic reticulum (GO:0072599)6.28472036
8protein localization to endoplasmic reticulum (GO:0070972)6.14667931
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.99536293
10translational elongation (GO:0006414)5.93233610
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.92826215
12cellular protein complex disassembly (GO:0043624)5.86630304
13maturation of SSU-rRNA (GO:0030490)5.82755518
14energy coupled proton transport, down electrochemical gradient (GO:0015985)5.68920804
15ATP synthesis coupled proton transport (GO:0015986)5.68920804
16electron transport chain (GO:0022900)5.57712749
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.56900721
18respiratory electron transport chain (GO:0022904)5.50991137
19viral life cycle (GO:0019058)5.41959019
20mitochondrial respiratory chain complex I assembly (GO:0032981)5.31391113
21NADH dehydrogenase complex assembly (GO:0010257)5.31391113
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.31391113
23ribosomal small subunit biogenesis (GO:0042274)5.28890582
24protein complex biogenesis (GO:0070271)5.27089805
25protein complex disassembly (GO:0043241)4.99426674
26translational initiation (GO:0006413)4.87989332
27macromolecular complex disassembly (GO:0032984)4.72332746
28mitochondrial respiratory chain complex assembly (GO:0033108)4.71397683
29spliceosomal complex assembly (GO:0000245)4.40572946
30protein targeting to membrane (GO:0006612)4.30882661
31protein localization to kinetochore (GO:0034501)4.30164365
32neuron remodeling (GO:0016322)4.01506564
33nuclear-transcribed mRNA catabolic process (GO:0000956)4.00633298
34attachment of spindle microtubules to kinetochore (GO:0008608)3.93168186
35regulation of mitochondrial translation (GO:0070129)3.85468638
36mRNA catabolic process (GO:0006402)3.84548676
37translation (GO:0006412)3.78056226
38protein localization to microtubule (GO:0035372)3.72285406
39serotonin metabolic process (GO:0042428)3.58165615
40regulation of cellular respiration (GO:0043457)3.52967029
41RNA catabolic process (GO:0006401)3.51039402
42hydrogen ion transmembrane transport (GO:1902600)3.44608895
43behavioral response to nicotine (GO:0035095)3.38213729
44negative regulation of heart rate (GO:0010459)3.37250008
45protein localization to chromosome, centromeric region (GO:0071459)3.37147000
46regulation of glomerular filtration (GO:0003093)3.27735689
47cytochrome complex assembly (GO:0017004)3.25565040
48sulfation (GO:0051923)3.21133866
49histone mRNA metabolic process (GO:0008334)3.20823109
50mature B cell differentiation involved in immune response (GO:0002313)3.19318777
51ATP biosynthetic process (GO:0006754)3.11598248
52protein polyglutamylation (GO:0018095)3.06653275
53proton transport (GO:0015992)3.06578413
54synapsis (GO:0007129)3.04535631
55negative regulation of transcription regulatory region DNA binding (GO:2000678)3.03830696
56positive regulation of fibroblast migration (GO:0010763)3.02767467
57microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.01081298
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.01022780
59hydrogen transport (GO:0006818)3.00035766
60aerobic respiration (GO:0009060)2.95885708
61primary amino compound metabolic process (GO:1901160)2.92822655
62viral mRNA export from host cell nucleus (GO:0046784)2.91679193
63spliceosomal snRNP assembly (GO:0000387)2.90329465
64establishment of protein localization to membrane (GO:0090150)2.89108603
65respiratory chain complex IV assembly (GO:0008535)2.86637182
66regulation of histone phosphorylation (GO:0033127)2.84985502
67one-carbon compound transport (GO:0019755)2.84879092
68epithelial cilium movement (GO:0003351)2.83166414
69chromatin remodeling at centromere (GO:0031055)2.80593808
70post-anal tail morphogenesis (GO:0036342)2.80570430
71purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75304138
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74392959
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73126397
74indole-containing compound metabolic process (GO:0042430)2.72820428
75translesion synthesis (GO:0019985)2.70912638
76flavonoid metabolic process (GO:0009812)2.69306661
77circadian sleep/wake cycle process (GO:0022410)2.68673985
78ribosomal large subunit biogenesis (GO:0042273)2.67445596
79protein targeting (GO:0006605)2.66749828
80establishment of protein localization to organelle (GO:0072594)2.64278151
81transmission of nerve impulse (GO:0019226)2.63982894
82positive regulation of mast cell activation involved in immune response (GO:0033008)2.61849251
83positive regulation of mast cell degranulation (GO:0043306)2.61849251
84neuron fate determination (GO:0048664)2.61824104
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61464816
86positive regulation of heart rate (GO:0010460)2.60354768
87histone-serine phosphorylation (GO:0035404)2.59805667
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.59509674
89termination of RNA polymerase III transcription (GO:0006386)2.59509674
90CENP-A containing nucleosome assembly (GO:0034080)2.59256873
91cellular component biogenesis (GO:0044085)2.57907121
92pyrimidine nucleobase catabolic process (GO:0006208)2.56654296
93regulation of urine volume (GO:0035809)2.54563403
94spinal cord motor neuron differentiation (GO:0021522)2.53858961
95epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.48300806
96interleukin-1-mediated signaling pathway (GO:0070498)2.46568972
97cellular respiration (GO:0045333)2.45836895
98positive regulation of respiratory burst (GO:0060267)2.45431803
99DNA replication-dependent nucleosome assembly (GO:0006335)2.43804523
100response to pheromone (GO:0019236)15.9045178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.12418559
2EZH2_22144423_ChIP-Seq_EOC_Human3.84204384
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.67039150
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.34564692
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28729889
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28136734
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15857938
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83191018
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79654673
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78707563
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65262037
12VDR_22108803_ChIP-Seq_LS180_Human2.40368212
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28669063
14MYC_18940864_ChIP-ChIP_HL60_Human2.27080654
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.14371708
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.09755046
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08684612
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06318277
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.97319101
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94222031
21EWS_26573619_Chip-Seq_HEK293_Human1.90828772
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.87894007
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85699443
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78766570
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77417709
26ELK1_19687146_ChIP-ChIP_HELA_Human1.74583694
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.72160188
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.71204941
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70529557
30TTF2_22483619_ChIP-Seq_HELA_Human1.68058556
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67521737
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58587522
33TP53_22573176_ChIP-Seq_HFKS_Human1.53685316
34GBX2_23144817_ChIP-Seq_PC3_Human1.51051961
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50876760
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50780365
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48012991
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47696525
39VDR_23849224_ChIP-Seq_CD4+_Human1.41899997
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40687289
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39724400
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39090811
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38792146
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.37976951
45IRF1_19129219_ChIP-ChIP_H3396_Human1.36468915
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36171461
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35622864
48ER_23166858_ChIP-Seq_MCF-7_Human1.34093081
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32176596
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.30612995
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30426948
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30426948
53FUS_26573619_Chip-Seq_HEK293_Human1.28536891
54P300_19829295_ChIP-Seq_ESCs_Human1.27335922
55TAF15_26573619_Chip-Seq_HEK293_Human1.24856344
56AR_21572438_ChIP-Seq_LNCaP_Human1.23670161
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17682236
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13678351
59REST_21632747_ChIP-Seq_MESCs_Mouse1.13591412
60AR_25329375_ChIP-Seq_VCAP_Human1.13071482
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.12104748
62E2F7_22180533_ChIP-Seq_HELA_Human1.10322367
63FOXP3_21729870_ChIP-Seq_TREG_Human1.09906819
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06893304
65RNF2_27304074_Chip-Seq_NSC_Mouse1.06689139
66TAF2_19829295_ChIP-Seq_ESCs_Human1.06073601
67BCAT_22108803_ChIP-Seq_LS180_Human1.06046161
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03799219
69AR_20517297_ChIP-Seq_VCAP_Human1.03774558
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.02995267
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02600424
72ERG_20517297_ChIP-Seq_VCAP_Human1.01545307
73NCOR_22424771_ChIP-Seq_293T_Human1.01469167
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00550429
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00395809
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.00289809
77EZH2_27294783_Chip-Seq_ESCs_Mouse0.99668090
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.97678014
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.97020913
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97020913
81MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96711928
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96548358
83CBP_20019798_ChIP-Seq_JUKART_Human0.96484800
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96484800
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.95827825
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95382067
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95184870
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95133943
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94794997
90RAC3_21632823_ChIP-Seq_H3396_Human0.94556782
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93937066
92XRN2_22483619_ChIP-Seq_HELA_Human0.93825602
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93114317
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92758652
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88792412
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88114857
97TP53_16413492_ChIP-PET_HCT116_Human0.87445217
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86851266
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86787166
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86395687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.20815655
2MP0002938_white_spotting2.89005943
3MP0003880_abnormal_central_pattern2.85024113
4MP0005423_abnormal_somatic_nervous2.73932013
5MP0004145_abnormal_muscle_electrophysio2.73391090
6MP0001529_abnormal_vocalization2.67395612
7MP0004142_abnormal_muscle_tone2.53453036
8MP0005084_abnormal_gallbladder_morpholo2.37913554
9MP0006292_abnormal_olfactory_placode2.23354398
10MP0002653_abnormal_ependyma_morphology2.23199297
11MP0003123_paternal_imprinting2.08871509
12MP0006276_abnormal_autonomic_nervous2.06417438
13MP0005367_renal/urinary_system_phenotyp2.03092498
14MP0000516_abnormal_urinary_system2.03092498
15MP0005408_hypopigmentation2.02905589
16MP0003315_abnormal_perineum_morphology1.98972380
17MP0005083_abnormal_biliary_tract1.97742116
18MP0002837_dystrophic_cardiac_calcinosis1.94287515
19MP0002638_abnormal_pupillary_reflex1.81701124
20MP0003890_abnormal_embryonic-extraembry1.66043687
21MP0005174_abnormal_tail_pigmentation1.58530472
22MP0002928_abnormal_bile_duct1.55460730
23MP0005551_abnormal_eye_electrophysiolog1.54312953
24MP0005365_abnormal_bile_salt1.53582366
25MP0005503_abnormal_tendon_morphology1.52957601
26MP0006072_abnormal_retinal_apoptosis1.49388558
27MP0002160_abnormal_reproductive_system1.42777832
28MP0001905_abnormal_dopamine_level1.42266088
29MP0003136_yellow_coat_color1.39516319
30MP0008995_early_reproductive_senescence1.37005376
31MP0002734_abnormal_mechanical_nocicepti1.34019690
32MP0002064_seizures1.32239759
33MP0004742_abnormal_vestibular_system1.28096414
34MP0000569_abnormal_digit_pigmentation1.22090990
35MP0005085_abnormal_gallbladder_physiolo1.21175382
36MP0001188_hyperpigmentation1.19559741
37MP0009745_abnormal_behavioral_response1.19157513
38MP0009046_muscle_twitch1.13554957
39MP0001486_abnormal_startle_reflex1.12372670
40MP0000778_abnormal_nervous_system1.11775263
41MP0002272_abnormal_nervous_system1.09656717
42MP0005646_abnormal_pituitary_gland1.09083922
43MP0000049_abnormal_middle_ear1.08492710
44MP0002163_abnormal_gland_morphology1.07891690
45MP0008789_abnormal_olfactory_epithelium1.05315371
46MP0003195_calcinosis1.04757342
47MP0008875_abnormal_xenobiotic_pharmacok1.04438735
48MP0002572_abnormal_emotion/affect_behav1.03757140
49MP0005075_abnormal_melanosome_morpholog1.02409586
50MP0005253_abnormal_eye_physiology1.01547913
51MP0002090_abnormal_vision1.01545027
52MP0002067_abnormal_sensory_capabilities1.00945904
53MP0002557_abnormal_social/conspecific_i0.99897475
54MP0008877_abnormal_DNA_methylation0.99787487
55MP0005195_abnormal_posterior_eye0.99081171
56MP0002752_abnormal_somatic_nervous0.97705202
57MP0002095_abnormal_skin_pigmentation0.97555491
58MP0000026_abnormal_inner_ear0.96773178
59MP0002822_catalepsy0.95358543
60MP0000631_abnormal_neuroendocrine_gland0.94197061
61MP0003693_abnormal_embryo_hatching0.93777543
62MP0001286_abnormal_eye_development0.93337952
63MP0002234_abnormal_pharynx_morphology0.92232324
64MP0001986_abnormal_taste_sensitivity0.91143724
65MP0005187_abnormal_penis_morphology0.90368954
66MP0002736_abnormal_nociception_after0.90223479
67MP0008872_abnormal_physiological_respon0.89843389
68MP0000534_abnormal_ureter_morphology0.88807206
69MP0002184_abnormal_innervation0.88175759
70MP0004134_abnormal_chest_morphology0.87994495
71MP0003252_abnormal_bile_duct0.87943348
72MP0001293_anophthalmia0.87196951
73MP0003941_abnormal_skin_development0.86514050
74MP0005332_abnormal_amino_acid0.86268184
75MP0000750_abnormal_muscle_regeneration0.85274339
76MP0001968_abnormal_touch/_nociception0.84924389
77MP0003718_maternal_effect0.84288765
78MP0005391_vision/eye_phenotype0.83797986
79MP0010386_abnormal_urinary_bladder0.82801921
80MP0001324_abnormal_eye_pigmentation0.81791587
81MP0005389_reproductive_system_phenotype0.80790183
82MP0003635_abnormal_synaptic_transmissio0.79425693
83MP0002277_abnormal_respiratory_mucosa0.79182875
84MP0010030_abnormal_orbit_morphology0.76503634
85MP0003936_abnormal_reproductive_system0.75641326
86MP0003121_genomic_imprinting0.75151292
87MP0005394_taste/olfaction_phenotype0.73698408
88MP0005499_abnormal_olfactory_system0.73698408
89MP0001963_abnormal_hearing_physiology0.71993878
90MP0003646_muscle_fatigue0.70214988
91MP0001666_abnormal_nutrient_absorption0.69943355
92MP0002111_abnormal_tail_morphology0.69789893
93MP0003937_abnormal_limbs/digits/tail_de0.69200990
94MP0003942_abnormal_urinary_system0.68711859
95MP0004147_increased_porphyrin_level0.68529661
96MP0003638_abnormal_response/metabolism_0.67674299
97MP0002735_abnormal_chemical_nociception0.66959017
98MP0002210_abnormal_sex_determination0.65590668
99MP0004885_abnormal_endolymph0.64632828
100MP0009250_abnormal_appendicular_skeleto0.63352012

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.57480341
2Acute necrotizing encephalopathy (HP:0006965)4.93770077
3Aplastic anemia (HP:0001915)4.76207814
4Congenital, generalized hypertrichosis (HP:0004540)4.70699097
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.65626633
6Acute encephalopathy (HP:0006846)4.28974404
7Abnormal mitochondria in muscle tissue (HP:0008316)4.20743619
8Chromsome breakage (HP:0040012)4.11900887
9Mitochondrial inheritance (HP:0001427)3.92984383
10Congenital stationary night blindness (HP:0007642)3.92955539
11Progressive macrocephaly (HP:0004481)3.90636059
12Abnormal number of erythroid precursors (HP:0012131)3.78606955
13Abnormality of cells of the erythroid lineage (HP:0012130)3.66393574
14Abnormality of alanine metabolism (HP:0010916)3.60440470
15Hyperalaninemia (HP:0003348)3.60440470
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.60440470
1711 pairs of ribs (HP:0000878)3.12579487
18Abnormality of DNA repair (HP:0003254)3.11919662
19Increased CSF lactate (HP:0002490)3.04474766
20Hepatocellular necrosis (HP:0001404)2.98445082
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97697817
223-Methylglutaconic aciduria (HP:0003535)2.90185791
23Cerebral edema (HP:0002181)2.89074516
24Macrocytic anemia (HP:0001972)2.84277643
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.75676063
26Pendular nystagmus (HP:0012043)2.74088830
27Hepatic necrosis (HP:0002605)2.72355424
28Abolished electroretinogram (ERG) (HP:0000550)2.70503053
29Leukodystrophy (HP:0002415)2.67673280
30Increased hepatocellular lipid droplets (HP:0006565)2.63644688
31Spastic paraparesis (HP:0002313)2.62201181
32Duplicated collecting system (HP:0000081)2.61297482
33Meckel diverticulum (HP:0002245)2.57545824
34Colon cancer (HP:0003003)2.55512263
35Abnormality of secondary sexual hair (HP:0009888)2.55048480
36Abnormality of the axillary hair (HP:0100134)2.55048480
37Oral leukoplakia (HP:0002745)2.49612710
38True hermaphroditism (HP:0010459)2.47902479
39Pallor (HP:0000980)2.44646961
40Abnormality of the renal collecting system (HP:0004742)2.42792571
41Abnormality of the preputium (HP:0100587)2.42476261
42Concave nail (HP:0001598)2.42391594
43Sclerocornea (HP:0000647)2.40790176
44Optic disc pallor (HP:0000543)2.40335462
45Pheochromocytoma (HP:0002666)2.39182368
46Lipid accumulation in hepatocytes (HP:0006561)2.38357552
47Pancreatic fibrosis (HP:0100732)2.38342783
48Abnormality of midbrain morphology (HP:0002418)2.37725557
49Molar tooth sign on MRI (HP:0002419)2.37725557
50Abnormality of the ileum (HP:0001549)2.37674242
51Medulloblastoma (HP:0002885)2.37306001
52Abnormality of the parietal bone (HP:0002696)2.33812035
53Severe visual impairment (HP:0001141)2.30081503
54Septo-optic dysplasia (HP:0100842)2.26891399
55Triphalangeal thumb (HP:0001199)2.22883988
56Bilateral microphthalmos (HP:0007633)2.22405684
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.19930039
58Short thumb (HP:0009778)2.18713008
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14711673
60Anomalous pulmonary venous return (HP:0010772)2.04981557
61Renal Fanconi syndrome (HP:0001994)2.03363705
62Absent thumb (HP:0009777)2.01927531
63Clubbing of toes (HP:0100760)2.01305250
64Microretrognathia (HP:0000308)1.98192085
65Pancreatic cysts (HP:0001737)1.96086664
66Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92082458
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92082458
68Bone cyst (HP:0012062)1.91163382
69Pancytopenia (HP:0001876)1.90246378
70Blindness (HP:0000618)1.86972288
71Abnormality of the carotid arteries (HP:0005344)1.85936574
72Neuroendocrine neoplasm (HP:0100634)1.82287542
73Abnormal rod and cone electroretinograms (HP:0008323)1.81089102
74Confusion (HP:0001289)1.80766570
75Midline defect of the nose (HP:0004122)1.80650144
76Abnormality of the pulmonary veins (HP:0011718)1.79652117
77Abnormality of chromosome stability (HP:0003220)1.79368923
78Conjunctival hamartoma (HP:0100780)1.77444054
79Hypoplastic pelvis (HP:0008839)1.76839425
80Abnormality of the pubic bones (HP:0003172)1.73694789
81Duplication of thumb phalanx (HP:0009942)1.73627713
82Anencephaly (HP:0002323)1.71760087
83Hyperglycinuria (HP:0003108)1.71673548
84Breast hypoplasia (HP:0003187)1.71315274
85Arthropathy (HP:0003040)1.70974849
86Myotonia (HP:0002486)1.70096324
87Generalized aminoaciduria (HP:0002909)1.69853674
88Macular degeneration (HP:0000608)1.69289419
89Furrowed tongue (HP:0000221)1.67498931
90Attenuation of retinal blood vessels (HP:0007843)1.67398079
91Short 4th metacarpal (HP:0010044)1.67222456
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67222456
93Partial duplication of the phalanx of hand (HP:0009999)1.65121827
94Inability to walk (HP:0002540)1.64942428
95Agnosia (HP:0010524)1.64003655
96Cleft eyelid (HP:0000625)1.63223340
97Limb dystonia (HP:0002451)1.63021748
98Maternal diabetes (HP:0009800)1.61714818
99Abnormality of the lacrimal duct (HP:0011481)1.61327925
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.61215847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.12085926
2MAP3K123.72151938
3TAF13.44925488
4ACVR1B3.20983141
5ADRBK23.00311140
6NME12.98817813
7BMPR1B2.93174053
8GRK12.90138969
9CDC72.89269308
10TLK12.84043632
11WNK32.72470795
12TGFBR12.20176275
13VRK12.14358833
14BCKDK2.09176231
15ZAK1.90616771
16NEK21.75234940
17PINK11.67410336
18DYRK21.67287740
19MAP3K91.57298022
20PASK1.37387972
21EPHB21.37208319
22MAP3K21.33222403
23MAPK151.30835203
24BMPR21.28498733
25ADRBK11.26962955
26NUAK11.23000580
27EIF2AK21.22331605
28MAP2K21.18370160
29WNK41.17962491
30MAP3K41.13628373
31CASK1.12536124
32WEE11.03174735
33MAP2K70.99622681
34MAPK130.98880749
35MAPKAPK50.98472792
36MKNK10.97957260
37STK160.96058728
38FLT30.95420115
39BLK0.92807623
40CHEK20.91567143
41MARK10.90007780
42MAP2K40.89817186
43DAPK30.89600476
44TSSK60.86612472
45SMG10.85537393
46PNCK0.84742583
47ILK0.80635124
48GRK50.77815676
49ABL20.72695602
50CAMKK20.71563706
51DYRK1A0.71447226
52IKBKB0.67630849
53CSF1R0.65771920
54MAP2K10.65723594
55NME20.64980412
56EPHA40.64880905
57CDK30.63668260
58CAMK2A0.62873437
59RPS6KA50.61657271
60ATR0.61080601
61MYLK0.59247979
62CSNK1G30.59179922
63CSNK1G10.58201603
64EIF2AK10.57762051
65MAP3K110.56528423
66PLK40.56501848
67AURKB0.55366218
68MATK0.54301974
69NTRK10.51876082
70DYRK30.51763655
71CSNK1G20.49507024
72PKN10.49118497
73CSNK2A20.48321287
74NTRK20.48285816
75INSRR0.47357402
76LYN0.47080012
77CHUK0.46904682
78CSNK1A1L0.46550356
79CSNK1A10.45184879
80PRKACB0.42116772
81PRKACA0.40009994
82OBSCN0.39962429
83PRKCD0.39860359
84CDK11A0.38381885
85CDK150.38050133
86BUB10.37938722
87BRAF0.37644332
88CSNK2A10.37510497
89MAPK40.37147853
90GRK60.36990158
91PRKG10.36088843
92CDK180.34957565
93KSR20.33324025
94PLK30.33291457
95TIE10.33078521
96PRKCG0.31730063
97SIK20.31127163
98CDK190.30949529
99PRKCE0.30864848
100CAMK10.30788596

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.15775895
2Oxidative phosphorylation_Homo sapiens_hsa001905.14031766
3Parkinsons disease_Homo sapiens_hsa050124.41399679
4Alzheimers disease_Homo sapiens_hsa050103.24615120
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.01957603
6Huntingtons disease_Homo sapiens_hsa050162.99638770
7Cardiac muscle contraction_Homo sapiens_hsa042602.82049063
8Asthma_Homo sapiens_hsa053102.40053435
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.39534801
10Proteasome_Homo sapiens_hsa030502.37230096
11Protein export_Homo sapiens_hsa030602.26035365
12Homologous recombination_Homo sapiens_hsa034402.08279904
13Nicotine addiction_Homo sapiens_hsa050332.04668086
14RNA polymerase_Homo sapiens_hsa030202.02915376
15Phototransduction_Homo sapiens_hsa047441.92323184
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.76786544
17Mismatch repair_Homo sapiens_hsa034301.66807182
18Linoleic acid metabolism_Homo sapiens_hsa005911.63904666
19Nitrogen metabolism_Homo sapiens_hsa009101.61735561
20Spliceosome_Homo sapiens_hsa030401.55188863
21Fanconi anemia pathway_Homo sapiens_hsa034601.45415774
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41733590
23DNA replication_Homo sapiens_hsa030301.41221390
24One carbon pool by folate_Homo sapiens_hsa006701.21456322
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13672109
26Nucleotide excision repair_Homo sapiens_hsa034201.12950360
27Autoimmune thyroid disease_Homo sapiens_hsa053201.04368282
28Allograft rejection_Homo sapiens_hsa053300.97570908
29Graft-versus-host disease_Homo sapiens_hsa053320.96682096
30Morphine addiction_Homo sapiens_hsa050320.94869688
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94604268
32Cyanoamino acid metabolism_Homo sapiens_hsa004600.88609306
33Tryptophan metabolism_Homo sapiens_hsa003800.86716823
34GABAergic synapse_Homo sapiens_hsa047270.86489843
35Circadian entrainment_Homo sapiens_hsa047130.85973092
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83452541
37Systemic lupus erythematosus_Homo sapiens_hsa053220.82584214
38RNA degradation_Homo sapiens_hsa030180.81518222
39Fat digestion and absorption_Homo sapiens_hsa049750.79305998
40Bladder cancer_Homo sapiens_hsa052190.79168068
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79067749
42Cocaine addiction_Homo sapiens_hsa050300.78388680
43Regulation of autophagy_Homo sapiens_hsa041400.78184328
44Serotonergic synapse_Homo sapiens_hsa047260.77966348
45Purine metabolism_Homo sapiens_hsa002300.77230297
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75825055
47Histidine metabolism_Homo sapiens_hsa003400.74122000
48Chemical carcinogenesis_Homo sapiens_hsa052040.73323923
49Arachidonic acid metabolism_Homo sapiens_hsa005900.72383190
50Sulfur relay system_Homo sapiens_hsa041220.71895042
51Vitamin digestion and absorption_Homo sapiens_hsa049770.71395521
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71155775
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69115473
54Pyrimidine metabolism_Homo sapiens_hsa002400.69052326
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68834927
56RNA transport_Homo sapiens_hsa030130.68014657
57Basal cell carcinoma_Homo sapiens_hsa052170.67847940
58Ether lipid metabolism_Homo sapiens_hsa005650.66898661
59Olfactory transduction_Homo sapiens_hsa047400.65767524
60Basal transcription factors_Homo sapiens_hsa030220.64817931
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64211056
62Type I diabetes mellitus_Homo sapiens_hsa049400.64125419
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58755759
64Glutamatergic synapse_Homo sapiens_hsa047240.56830152
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56093765
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.54398187
67beta-Alanine metabolism_Homo sapiens_hsa004100.53948180
68Antigen processing and presentation_Homo sapiens_hsa046120.52938247
69Selenocompound metabolism_Homo sapiens_hsa004500.52660301
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47921796
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47906864
72Staphylococcus aureus infection_Homo sapiens_hsa051500.47219279
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45278458
74Metabolic pathways_Homo sapiens_hsa011000.42883905
75Tyrosine metabolism_Homo sapiens_hsa003500.40585385
76Taste transduction_Homo sapiens_hsa047420.39806758
77Melanoma_Homo sapiens_hsa052180.35702696
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35028409
79Alcoholism_Homo sapiens_hsa050340.34877414
80Base excision repair_Homo sapiens_hsa034100.33567084
81Hedgehog signaling pathway_Homo sapiens_hsa043400.32998900
82Amphetamine addiction_Homo sapiens_hsa050310.31108423
83Folate biosynthesis_Homo sapiens_hsa007900.30616015
84Epstein-Barr virus infection_Homo sapiens_hsa051690.28431869
85Steroid biosynthesis_Homo sapiens_hsa001000.28073297
86Glutathione metabolism_Homo sapiens_hsa004800.26806285
87Rheumatoid arthritis_Homo sapiens_hsa053230.21996376
88Fatty acid biosynthesis_Homo sapiens_hsa000610.21803387
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21519513
90Dopaminergic synapse_Homo sapiens_hsa047280.20832254
91Collecting duct acid secretion_Homo sapiens_hsa049660.20493564
92Caffeine metabolism_Homo sapiens_hsa002320.20487225
93Calcium signaling pathway_Homo sapiens_hsa040200.19814611
94Mineral absorption_Homo sapiens_hsa049780.18192215
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.17769555
96Hematopoietic cell lineage_Homo sapiens_hsa046400.14885146
97Phenylalanine metabolism_Homo sapiens_hsa003600.12990370
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12635260
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12407962
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10736618

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