PPP1R14A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment (GO:0008366)7.45741548
2ensheathment of neurons (GO:0007272)7.45741548
3myelination (GO:0042552)7.36206234
4fatty acid elongation (GO:0030497)7.31204659
5myelin maintenance (GO:0043217)6.68932110
6long-chain fatty acid biosynthetic process (GO:0042759)5.83288574
7creatine metabolic process (GO:0006600)5.45454746
8oligodendrocyte differentiation (GO:0048709)5.26306992
9establishment of mitochondrion localization (GO:0051654)4.90756608
10negative regulation of protein localization to cell surface (GO:2000009)4.52746096
11regulation of collateral sprouting (GO:0048670)4.39305846
12adenosine receptor signaling pathway (GO:0001973)4.38032320
13positive regulation of oligodendrocyte differentiation (GO:0048714)4.29643607
14astrocyte development (GO:0014002)4.26180920
15peptidyl-tyrosine autophosphorylation (GO:0038083)4.22214944
16eye photoreceptor cell differentiation (GO:0001754)4.16934554
17photoreceptor cell differentiation (GO:0046530)4.16934554
18response to methylmercury (GO:0051597)4.15010990
19synaptic vesicle maturation (GO:0016188)4.14254212
20negative regulation of neurotransmitter secretion (GO:0046929)4.13625647
21negative regulation of neurotransmitter transport (GO:0051589)4.09866466
22regulation of catecholamine metabolic process (GO:0042069)4.05745299
23regulation of dopamine metabolic process (GO:0042053)4.05745299
24amyloid precursor protein metabolic process (GO:0042982)4.02879590
25apical protein localization (GO:0045176)4.01246772
26presynaptic membrane organization (GO:0097090)3.98169385
27membrane tubulation (GO:0097320)3.93461199
28negative regulation of execution phase of apoptosis (GO:1900118)3.92570701
29cholesterol biosynthetic process (GO:0006695)3.92447873
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.91968006
31relaxation of smooth muscle (GO:0044557)3.82665344
32glutamate secretion (GO:0014047)3.79678110
33asymmetric protein localization (GO:0008105)3.78872926
34regulation of lipoprotein metabolic process (GO:0050746)3.77156278
35substantia nigra development (GO:0021762)3.72240864
36import into cell (GO:0098657)3.68830634
37neuron remodeling (GO:0016322)3.68219342
38heme transport (GO:0015886)3.66312177
39prostaglandin biosynthetic process (GO:0001516)3.60415493
40prostanoid biosynthetic process (GO:0046457)3.60415493
41myelination in peripheral nervous system (GO:0022011)3.59218835
42peripheral nervous system axon ensheathment (GO:0032292)3.59218835
43L-amino acid import (GO:0043092)3.57812033
44adult walking behavior (GO:0007628)3.54405771
45enteric nervous system development (GO:0048484)3.53689562
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.53381166
47regulation of synaptic vesicle exocytosis (GO:2000300)3.53181667
48regulation of oxidative phosphorylation (GO:0002082)3.49587372
49response to lead ion (GO:0010288)3.49024947
50response to redox state (GO:0051775)3.47795348
51glycerophospholipid catabolic process (GO:0046475)3.47041987
52synaptic vesicle exocytosis (GO:0016079)3.44314893
53sterol biosynthetic process (GO:0016126)3.44251235
54long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.41109200
55iron coordination entity transport (GO:1901678)3.40831717
56short-term memory (GO:0007614)3.40145402
57limb bud formation (GO:0060174)3.39758111
58substrate-independent telencephalic tangential migration (GO:0021826)3.37615995
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.37615995
60cyclooxygenase pathway (GO:0019371)3.37514891
61positive regulation of glial cell differentiation (GO:0045687)3.34061186
62negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.31076568
63negative regulation of macroautophagy (GO:0016242)3.28203981
64extracellular fibril organization (GO:0043206)3.27440724
65glial cell development (GO:0021782)3.26933791
66axon development (GO:0061564)3.26192101
67positive regulation of gliogenesis (GO:0014015)3.26008331
682-deoxyribonucleotide biosynthetic process (GO:0009265)3.23851119
69deoxyribose phosphate biosynthetic process (GO:0046385)3.23851119
70potassium ion homeostasis (GO:0055075)3.22809205
71positive regulation of cellular amine metabolic process (GO:0033240)3.20648579
72regulation of integrin-mediated signaling pathway (GO:2001044)3.19473306
73response to lipoprotein particle (GO:0055094)3.18963251
74platelet aggregation (GO:0070527)3.16772706
75GPI anchor biosynthetic process (GO:0006506)3.16416604
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14533775
77glycine transport (GO:0015816)3.14446673
78long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.13970268
79neurotransmitter uptake (GO:0001504)3.13245952
80barbed-end actin filament capping (GO:0051016)3.12674580
81regulation of sensory perception of pain (GO:0051930)3.11283955
82regulation of sensory perception (GO:0051931)3.11283955
83protein palmitoylation (GO:0018345)3.10015169
84negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.09318220
85negative regulation of calcium ion transmembrane transport (GO:1903170)3.09318220
86regulation of neuronal synaptic plasticity (GO:0048168)3.09129264
87positive regulation of pseudopodium assembly (GO:0031274)3.08889878
88regulation of exit from mitosis (GO:0007096)3.06025359
89protein neddylation (GO:0045116)3.05138313
90isoprenoid biosynthetic process (GO:0008299)3.04900431
91positive regulation of Rho protein signal transduction (GO:0035025)3.02412296
92regulation of interleukin-13 production (GO:0032656)3.02119879
93negative regulation of axonogenesis (GO:0050771)3.01687178
94cerebellar granule cell differentiation (GO:0021707)2.98549265
95regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98299059
96regulation of voltage-gated calcium channel activity (GO:1901385)2.97807804
97microtubule polymerization or depolymerization (GO:0031109)2.97639271
98regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.97063217
99regulation of circadian sleep/wake cycle (GO:0042749)2.97063217
100female mating behavior (GO:0060180)2.95808763
101negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.95729291
102negative regulation of appetite (GO:0032099)2.95603325
103negative regulation of response to food (GO:0032096)2.95603325
104nucleoside diphosphate biosynthetic process (GO:0009133)2.95264352
105GPI anchor metabolic process (GO:0006505)2.95120843
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94613422
107fatty-acyl-CoA biosynthetic process (GO:0046949)2.94593625
108lateral sprouting from an epithelium (GO:0060601)2.94135273
109amyloid precursor protein catabolic process (GO:0042987)2.94001333
110negative regulation of norepinephrine secretion (GO:0010700)2.93912524
111L-phenylalanine catabolic process (GO:0006559)2.92873022
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.92873022
113virion attachment to host cell (GO:0019062)2.92755040
114adhesion of symbiont to host cell (GO:0044650)2.92755040
115organ growth (GO:0035265)2.91972659
116peptidyl-cysteine modification (GO:0018198)2.89800933
117extracellular matrix assembly (GO:0085029)2.89461072
118negative regulation of JUN kinase activity (GO:0043508)2.84404200
119positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83839654
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82836578
121regulation of synaptic vesicle transport (GO:1902803)2.81895458
122positive regulation of receptor recycling (GO:0001921)2.81717740
123very long-chain fatty acid metabolic process (GO:0000038)2.81666550
124regulation of female receptivity (GO:0045924)2.81299044
125negative regulation of heart rate (GO:0010459)2.80860359
126fatty-acyl-CoA metabolic process (GO:0035337)2.79988354
127regulation of glomerular filtration (GO:0003093)2.79827199
128positive regulation of cellular amide metabolic process (GO:0034250)2.78823214
129regulation of pseudopodium assembly (GO:0031272)2.78028991
130gas transport (GO:0015669)2.77909996
131glial cell differentiation (GO:0010001)2.77447361
132circadian sleep/wake cycle process (GO:0022410)2.77313190
133detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.75072996
134detection of temperature stimulus involved in sensory perception (GO:0050961)2.75072996
135regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74695522
136negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74666728
137magnesium ion transport (GO:0015693)2.74403651
138locomotory exploration behavior (GO:0035641)2.73348553
139regulation of hydrogen peroxide-induced cell death (GO:1903205)2.72838020
140regulation of amyloid precursor protein catabolic process (GO:1902991)2.72627101
141negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.72540490
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70992087
143response to water (GO:0009415)2.70242835
144amino acid import (GO:0043090)2.66379242
145negative regulation of cation channel activity (GO:2001258)2.66018329
146oligodendrocyte development (GO:0014003)2.63799907
147protein targeting to plasma membrane (GO:0072661)2.63131779
148positive regulation of toll-like receptor signaling pathway (GO:0034123)2.62494864
149negative regulation of response to reactive oxygen species (GO:1901032)2.61860362
150positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.61596447
151response to dietary excess (GO:0002021)2.61362105
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61334070
153L-phenylalanine metabolic process (GO:0006558)2.61334070
154glycosylceramide metabolic process (GO:0006677)2.61302739
155regulation of platelet aggregation (GO:0090330)2.60653555
156presynaptic membrane assembly (GO:0097105)2.60580414
157cellular potassium ion homeostasis (GO:0030007)2.60445689
158L-serine metabolic process (GO:0006563)2.59997071
159negative regulation of homotypic cell-cell adhesion (GO:0034111)2.59991538
160positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.59280494
161sodium ion export (GO:0071436)2.58861218
162cellular response to epinephrine stimulus (GO:0071872)2.58693332
163vesicle docking involved in exocytosis (GO:0006904)2.58038993
164regulation of autophagic vacuole assembly (GO:2000785)2.57337684
165neuronal ion channel clustering (GO:0045161)2.56838750
166preassembly of GPI anchor in ER membrane (GO:0016254)2.55880469
167cerebral cortex radially oriented cell migration (GO:0021799)2.55224364
168regulation of somitogenesis (GO:0014807)2.54849701
169neural nucleus development (GO:0048857)2.53365285
170positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.53326946
171axon ensheathment in central nervous system (GO:0032291)14.7150803
172central nervous system myelination (GO:0022010)14.7150803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.59367905
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94474339
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.70109262
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53023626
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.52043182
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51964911
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50643099
8SRY_22984422_ChIP-ChIP_TESTIS_Rat2.47798060
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.43403017
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33438998
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30625915
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25217083
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18496671
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18496671
15LXR_22292898_ChIP-Seq_THP-1_Human2.17377468
16GATA1_19941826_ChIP-Seq_K562_Human2.16864075
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14220183
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14149958
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.14014517
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07150323
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.07102741
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06401189
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05366834
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05366834
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05366834
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04472690
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98313375
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97314012
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95053432
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93038522
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.91737884
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89322789
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87711064
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86950047
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84418484
36SCL_19346495_ChIP-Seq_HPC-7_Human1.82249161
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82219461
38AR_21572438_ChIP-Seq_LNCaP_Human1.80999512
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80817551
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73393889
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71723027
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.70178351
43GBX2_23144817_ChIP-Seq_PC3_Human1.69129596
44STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.68705770
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67765552
46KDM2B_26808549_Chip-Seq_K562_Human1.64748519
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.61584092
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61391753
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.60150497
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56033146
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55878570
52P68_20966046_ChIP-Seq_HELA_Human1.54359323
53VDR_22108803_ChIP-Seq_LS180_Human1.52822050
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52640422
55EOMES_21245162_ChIP-Seq_HESCs_Human1.51634743
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50830316
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49666686
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49337295
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48093143
60EZH2_22144423_ChIP-Seq_EOC_Human1.46624153
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45798799
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44544807
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.42992270
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41740085
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41167106
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36486987
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.35584300
68RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34683284
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.32918089
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32084574
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31368013
72* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30833591
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.29951843
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29723692
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29140980
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.29063291
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.29017776
78DROSHA_22980978_ChIP-Seq_HELA_Human1.28078048
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27277966
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.26377177
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25953161
82SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.24141625
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23448979
84SA1_27219007_Chip-Seq_Bcells_Human1.23389963
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23333255
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23310528
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23019700
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22017786
89GATA2_19941826_ChIP-Seq_K562_Human1.21464256
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.20551413
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20351177
92OCT4_19829295_ChIP-Seq_ESCs_Human1.19925175
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19788070
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.19705049
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.19517106
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18480027
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17077876
98NCOR1_26117541_ChIP-Seq_K562_Human1.16985534
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.16771944
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.16239693
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.15464126
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14980397
103ER_23166858_ChIP-Seq_MCF-7_Human1.12915172
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12526090
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11379909
106BCL6_27268052_Chip-Seq_Bcells_Human1.11218389
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11183201
108SMC4_20622854_ChIP-Seq_HELA_Human1.10933743
109SPI1_20517297_ChIP-Seq_HL60_Human1.08888524
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.08546256
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.08531012
112CLOCK_20551151_ChIP-Seq_293T_Human1.08144840
113BCOR_27268052_Chip-Seq_Bcells_Human1.07704986
114KDM2B_26808549_Chip-Seq_DND41_Human1.06566477
115* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06061556
116ZNF263_19887448_ChIP-Seq_K562_Human1.05426187
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04690684
118TAF15_26573619_Chip-Seq_HEK293_Human1.04531317
119REST_21632747_ChIP-Seq_MESCs_Mouse1.04429541
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04327199
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03445157
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03035448
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02952384
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02214040
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01978445
126* CTCF_20526341_ChIP-Seq_ESCs_Human1.01668259
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00857121
128IRF1_19129219_ChIP-ChIP_H3396_Human1.00528623
129CTCF_27219007_Chip-Seq_Bcells_Human1.00431561
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99901006
131RACK7_27058665_Chip-Seq_MCF-7_Human0.99621529
132SPI1_23127762_ChIP-Seq_K562_Human0.97039688
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.96646214
134JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96566320
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96529117
136* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95636971
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95203105
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92123146
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92123146
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91877719
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.91609839
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90396901
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88279877
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.86924826
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85975700
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83509208
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.83427060
148SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82276059
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82166243
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80257646
151* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80065581
152* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77479772
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77132564
154HTT_18923047_ChIP-ChIP_STHdh_Human0.76685130
155FOXH1_21741376_ChIP-Seq_ESCs_Human0.76534702
156EP300_21415370_ChIP-Seq_HL-1_Mouse0.76277101
157TP53_20018659_ChIP-ChIP_R1E_Mouse0.75453984
158KLF4_19829295_ChIP-Seq_ESCs_Human0.75043707
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.74886685
160ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73697786
161TAL1_26923725_Chip-Seq_HPCs_Mouse0.73398503
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71781159
163WT1_19549856_ChIP-ChIP_CCG9911_Human0.71292427
164NANOG_19829295_ChIP-Seq_ESCs_Human0.70293124
165SOX2_19829295_ChIP-Seq_ESCs_Human0.70293124
166SA1_22415368_ChIP-Seq_MEFs_Mouse0.70260332
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.69378807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.70917201
2MP0003950_abnormal_plasma_membrane3.94077843
3MP0003880_abnormal_central_pattern3.64683302
4MP0003136_yellow_coat_color3.60333686
5MP0005464_abnormal_platelet_physiology3.38954649
6MP0005171_absent_coat_pigmentation3.03033203
7MP0004270_analgesia2.78472896
8MP0003690_abnormal_glial_cell2.75488239
9MP0004885_abnormal_endolymph2.73203520
10MP0005670_abnormal_white_adipose2.71364608
11MP0004142_abnormal_muscle_tone2.57491786
12MP0003329_amyloid_beta_deposits2.54802322
13MP0001529_abnormal_vocalization2.49204132
14MP0004742_abnormal_vestibular_system2.49130078
15MP0008260_abnormal_autophagy2.45498227
16MP0004381_abnormal_hair_follicle2.41962688
17MP0003634_abnormal_glial_cell2.35538451
18MP0002272_abnormal_nervous_system2.35274220
19MP0005423_abnormal_somatic_nervous2.20203444
20MP0001486_abnormal_startle_reflex2.11551265
21MP0000778_abnormal_nervous_system2.11164784
22MP0001905_abnormal_dopamine_level2.10932491
23MP0001968_abnormal_touch/_nociception2.06321407
24MP0004084_abnormal_cardiac_muscle2.03912310
25MP0005409_darkened_coat_color2.01167611
26MP0005646_abnormal_pituitary_gland2.00160101
27MP0005410_abnormal_fertilization1.92450587
28MP0008004_abnormal_stomach_pH1.89881104
29MP0001485_abnormal_pinna_reflex1.85455989
30MP0002064_seizures1.83442450
31MP0006276_abnormal_autonomic_nervous1.82630694
32MP0000462_abnormal_digestive_system1.80988167
33MP0003186_abnormal_redox_activity1.80459054
34MP0002229_neurodegeneration1.79491588
35MP0001545_abnormal_hematopoietic_system1.77124281
36MP0005397_hematopoietic_system_phenotyp1.77124281
37MP0003632_abnormal_nervous_system1.71067266
38MP0005623_abnormal_meninges_morphology1.67706526
39MP0003075_altered_response_to1.67441394
40MP0004043_abnormal_pH_regulation1.66700588
41MP0005666_abnormal_adipose_tissue1.65687424
42MP0002736_abnormal_nociception_after1.63686466
43MP0005167_abnormal_blood-brain_barrier1.63318388
44MP0003806_abnormal_nucleotide_metabolis1.61499148
45MP0010678_abnormal_skin_adnexa1.60972249
46MP0009840_abnormal_foam_cell1.60875893
47MP0005503_abnormal_tendon_morphology1.60817994
48MP0001346_abnormal_lacrimal_gland1.59653068
49MP0000383_abnormal_hair_follicle1.56032394
50MP0006138_congestive_heart_failure1.51790480
51MP0005451_abnormal_body_composition1.51566551
52MP0000955_abnormal_spinal_cord1.51460036
53MP0006036_abnormal_mitochondrial_physio1.48995127
54MP0008438_abnormal_cutaneous_collagen1.47253889
55MP0003879_abnormal_hair_cell1.46838205
56MP0004215_abnormal_myocardial_fiber1.40761068
57MP0005058_abnormal_lysosome_morphology1.40028022
58MP0000747_muscle_weakness1.38431474
59MP0004859_abnormal_synaptic_plasticity1.37779488
60MP0008874_decreased_physiological_sensi1.37413467
61MP0003631_nervous_system_phenotype1.35784865
62MP0008569_lethality_at_weaning1.32761840
63MP0004130_abnormal_muscle_cell1.32639330
64MP0002734_abnormal_mechanical_nocicepti1.29575876
65MP0005275_abnormal_skin_tensile1.28920362
66MP0000762_abnormal_tongue_morphology1.28288409
67MP0000343_altered_response_to1.28174495
68MP0002822_catalepsy1.27976726
69MP0004134_abnormal_chest_morphology1.27737099
70MP0002882_abnormal_neuron_morphology1.26200748
71MP0004145_abnormal_muscle_electrophysio1.22672172
72MP0009278_abnormal_bone_marrow1.22533726
73MP0000566_synostosis1.20759454
74MP0005551_abnormal_eye_electrophysiolog1.18650566
75MP0003635_abnormal_synaptic_transmissio1.18461372
76MP0002752_abnormal_somatic_nervous1.17667992
77MP0003566_abnormal_cell_adhesion1.17086294
78MP0009745_abnormal_behavioral_response1.16729693
79MP0002066_abnormal_motor_capabilities/c1.16129108
80MP0005535_abnormal_body_temperature1.13711477
81MP0001970_abnormal_pain_threshold1.11969348
82MP0009046_muscle_twitch1.11953758
83MP0003633_abnormal_nervous_system1.11610048
84MP0009780_abnormal_chondrocyte_physiolo1.11349205
85MP0003938_abnormal_ear_development1.10987402
86MP0002653_abnormal_ependyma_morphology1.10612514
87MP0004133_heterotaxia1.10434128
88MP0003279_aneurysm1.08731738
89MP0005165_increased_susceptibility_to1.08376004
90MP0000647_abnormal_sebaceous_gland1.08179248
91MP0000230_abnormal_systemic_arterial1.08145544
92MP0000604_amyloidosis1.06483052
93MP0001963_abnormal_hearing_physiology1.05518037
94MP0010386_abnormal_urinary_bladder1.05173538
95MP0001502_abnormal_circadian_rhythm1.03794644
96MP0003195_calcinosis1.03482903
97MP0000467_abnormal_esophagus_morphology1.02702718
98MP0003638_abnormal_response/metabolism_1.00962121
99MP0005375_adipose_tissue_phenotype1.00734224
100MP0004858_abnormal_nervous_system1.00604745
101MP0008872_abnormal_physiological_respon0.98997068
102MP0004811_abnormal_neuron_physiology0.98091455
103MP0000579_abnormal_nail_morphology0.96964682
104MP0004272_abnormal_basement_membrane0.95673326
105MP0005195_abnormal_posterior_eye0.94403126
106MP0003137_abnormal_impulse_conducting0.93315044
107MP0005023_abnormal_wound_healing0.92390968
108MP0000751_myopathy0.92189446
109MP0002295_abnormal_pulmonary_circulatio0.89845805
110MP0002972_abnormal_cardiac_muscle0.89646391
111MP0002735_abnormal_chemical_nociception0.89264514
112MP0003937_abnormal_limbs/digits/tail_de0.88966819
113MP0004185_abnormal_adipocyte_glucose0.88798217
114MP0001299_abnormal_eye_distance/0.87333061
115MP0001177_atelectasis0.87173794
116MP0005620_abnormal_muscle_contractility0.86250900
117MP0004085_abnormal_heartbeat0.86048965
118MP0001440_abnormal_grooming_behavior0.85653635
119MP0001661_extended_life_span0.84099724
120MP0002572_abnormal_emotion/affect_behav0.83574235
121MP0004147_increased_porphyrin_level0.83546874
122MP0002067_abnormal_sensory_capabilities0.82337980
123MP0005166_decreased_susceptibility_to0.81275896
124MP0001544_abnormal_cardiovascular_syste0.79231193
125MP0005385_cardiovascular_system_phenoty0.79231193
126MP0001851_eye_inflammation0.78772009
127MP0002152_abnormal_brain_morphology0.77915884
128MP0001879_abnormal_lymphatic_vessel0.77833441
129MP0000026_abnormal_inner_ear0.77623809
130MP0009250_abnormal_appendicular_skeleto0.76339887
131MP0000003_abnormal_adipose_tissue0.75961784
132MP0002063_abnormal_learning/memory/cond0.74929872
133MP0000749_muscle_degeneration0.73865666
134MP0002733_abnormal_thermal_nociception0.73328247
135MP0004087_abnormal_muscle_fiber0.73310794
136MP0006082_CNS_inflammation0.71620467
137MP0001958_emphysema0.69577330
138MP0004036_abnormal_muscle_relaxation0.69095241
139MP0001348_abnormal_lacrimal_gland0.68672542
140MP0001340_abnormal_eyelid_morphology0.67240452
141MP0005386_behavior/neurological_phenoty0.67183836
142MP0004924_abnormal_behavior0.67183836
143MP0005388_respiratory_system_phenotype0.66907113
144MP0002133_abnormal_respiratory_system0.66907113
145MP0010030_abnormal_orbit_morphology0.66494410
146MP0000613_abnormal_salivary_gland0.64830899
147MP0005408_hypopigmentation0.63808227
148MP0005595_abnormal_vascular_smooth0.59661132
149MP0000639_abnormal_adrenal_gland0.58393711
150MP0005330_cardiomyopathy0.56476279
151MP0002938_white_spotting0.54945875
152MP0003453_abnormal_keratinocyte_physiol0.54487901
153MP0002184_abnormal_innervation0.53932835

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)6.79538718
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.88507323
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.88507323
4Neurofibrillary tangles (HP:0002185)5.88198169
5Peripheral hypomyelination (HP:0007182)4.96724507
6Prolonged bleeding time (HP:0003010)4.68528063
7Onion bulb formation (HP:0003383)4.34919591
8Sensory axonal neuropathy (HP:0003390)4.27444289
9Parakeratosis (HP:0001036)4.26952646
10Petechiae (HP:0000967)4.20324916
11Abnormal auditory evoked potentials (HP:0006958)4.13332700
12Abnormality of the corticospinal tract (HP:0002492)4.08143436
13Cerebral inclusion bodies (HP:0100314)4.07335148
14Alacrima (HP:0000522)3.99477320
15CNS hypomyelination (HP:0003429)3.95814738
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.87648780
17Increased mean platelet volume (HP:0011877)3.87462976
18Menorrhagia (HP:0000132)3.74562498
19Purpura (HP:0000979)3.73723351
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.56922205
21Abnormal platelet volume (HP:0011876)3.46309877
22Supranuclear gaze palsy (HP:0000605)3.44403159
23Segmental peripheral demyelination/remyelination (HP:0003481)3.44099786
24Leukodystrophy (HP:0002415)3.36110443
25Abnormality of the heme biosynthetic pathway (HP:0010472)3.23924157
26Muscle fiber splitting (HP:0003555)3.21945457
27Spastic paraparesis (HP:0002313)3.19753206
28Ankle clonus (HP:0011448)3.18577864
29Spastic gait (HP:0002064)3.14494948
30Split foot (HP:0001839)3.11468603
31Abnormality of binocular vision (HP:0011514)3.09656863
32Diplopia (HP:0000651)3.09656863
33Abnormality of the Achilles tendon (HP:0005109)3.07786925
34Achilles tendon contracture (HP:0001771)3.02179814
35Decreased lacrimation (HP:0000633)3.02011235
36Dysmetria (HP:0001310)2.90873256
37Absent septum pellucidum (HP:0001331)2.87956280
38Myokymia (HP:0002411)2.86279401
39Intention tremor (HP:0002080)2.82002571
40Axonal loss (HP:0003447)2.81207828
41Delusions (HP:0000746)2.80859326
42Insidious onset (HP:0003587)2.76917058
43Termporal pattern (HP:0011008)2.76917058
44Premature skin wrinkling (HP:0100678)2.76519089
45Epistaxis (HP:0000421)2.75916741
46Morphological abnormality of the inner ear (HP:0011390)2.74171766
47Aortic aneurysm (HP:0004942)2.71415797
48Slow saccadic eye movements (HP:0000514)2.71090910
49Foot dorsiflexor weakness (HP:0009027)2.70793030
50Truncus arteriosus (HP:0001660)2.68439447
51Hyperlipoproteinemia (HP:0010980)2.68103137
52Anteriorly placed anus (HP:0001545)2.65341147
53Thickened helices (HP:0000391)2.64049013
54Abnormality of the septum pellucidum (HP:0007375)2.60170751
55Hypoplasia of the iris (HP:0007676)2.59725706
56Paraparesis (HP:0002385)2.59115981
57Polycythemia (HP:0001901)2.58508745
58Focal motor seizures (HP:0011153)2.58216732
59Hyperthyroidism (HP:0000836)2.55406333
60Stridor (HP:0010307)2.54511531
61Abnormality of the periventricular white matter (HP:0002518)2.54487766
62Poor speech (HP:0002465)2.53977113
63Hypoplastic pelvis (HP:0008839)2.53617339
64Action tremor (HP:0002345)2.52443937
65Torticollis (HP:0000473)2.48713595
66Abnormality of the foot musculature (HP:0001436)2.47349911
67Clumsiness (HP:0002312)2.44719195
68Congenital ichthyosiform erythroderma (HP:0007431)2.44263766
69Coronal craniosynostosis (HP:0004440)2.43654900
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43123759
71Septo-optic dysplasia (HP:0100842)2.40731332
72Difficulty walking (HP:0002355)2.39925380
73White forelock (HP:0002211)2.37636627
74Craniofacial dystonia (HP:0012179)2.37313630
75Choreoathetosis (HP:0001266)2.37160088
76Scanning speech (HP:0002168)2.34477629
77Megalencephaly (HP:0001355)2.32403897
78Aplasia involving bones of the extremities (HP:0009825)2.31712014
79Aplasia involving bones of the upper limbs (HP:0009823)2.31712014
80Aplasia of the phalanges of the hand (HP:0009802)2.31712014
81Abnormality of the salivary glands (HP:0010286)2.31246598
82Patchy hypopigmentation of hair (HP:0011365)2.30838868
83Abnormal platelet function (HP:0011869)2.30540806
84Impaired platelet aggregation (HP:0003540)2.30540806
85Abnormality of glycolysis (HP:0004366)2.28919551
86Increased serum pyruvate (HP:0003542)2.28919551
87Partial duplication of thumb phalanx (HP:0009944)2.27283834
88Focal dystonia (HP:0004373)2.26453925
89Cerebral hemorrhage (HP:0001342)2.26444803
90Abnormal eating behavior (HP:0100738)2.25640940
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.24481111
92Esophageal atresia (HP:0002032)2.24469644
93Aortic dissection (HP:0002647)2.23504749
94Acute necrotizing encephalopathy (HP:0006965)2.22660946
95Prolonged neonatal jaundice (HP:0006579)2.22013742
96Clonus (HP:0002169)2.21372425
97Abnormal mitochondria in muscle tissue (HP:0008316)2.20443870
98Abnormal pupillary function (HP:0007686)2.19843559
99Spastic tetraparesis (HP:0001285)2.18819268
100Dysphonia (HP:0001618)2.17214603
101Retinal dysplasia (HP:0007973)2.16178275
102Hyporeflexia of lower limbs (HP:0002600)2.15698738
103Concave nail (HP:0001598)2.14347168
104Metaphyseal dysplasia (HP:0100255)2.13593554
105Atonic seizures (HP:0010819)2.11831938
106Peripheral demyelination (HP:0011096)2.11779618
107Ventricular fibrillation (HP:0001663)2.11478533
108Decreased motor nerve conduction velocity (HP:0003431)2.11120758
109Episodic fever (HP:0001954)2.09973049
110Visual hallucinations (HP:0002367)2.08260645
111Acute encephalopathy (HP:0006846)2.07879977
112Abnormal large intestine physiology (HP:0012700)2.06622264
113Gowers sign (HP:0003391)2.06488080
114Abnormality of the middle phalanges of the toes (HP:0010183)2.05925147
115Partial duplication of the phalanx of hand (HP:0009999)2.05338250
116Premature rupture of membranes (HP:0001788)2.05128731
117Progressive macrocephaly (HP:0004481)2.03602348
118Abnormality of the fetal cardiovascular system (HP:0010948)2.02205340
119Abnormal umbilical cord blood vessels (HP:0011403)2.02205340
120Single umbilical artery (HP:0001195)2.02205340
121Hepatosplenomegaly (HP:0001433)1.99549708
122Synostosis involving the elbow (HP:0003938)1.98071945
123Humeroradial synostosis (HP:0003041)1.98071945
124Distal sensory impairment (HP:0002936)1.97168799
125Focal seizures (HP:0007359)1.96594344
126Hypophosphatemic rickets (HP:0004912)1.96181352
127Pheochromocytoma (HP:0002666)1.95967471
128Rigidity (HP:0002063)1.95742642
129Increased circulating renin level (HP:0000848)1.95566473
130Obstructive sleep apnea (HP:0002870)1.93689598
131Limb dystonia (HP:0002451)1.91798161
132Lower limb amyotrophy (HP:0007210)1.91078764
133Gingival bleeding (HP:0000225)1.90923251
134Autoamputation (HP:0001218)1.90771841
135Postural instability (HP:0002172)1.89021609
136Protrusio acetabuli (HP:0003179)1.88170670
137Cellulitis (HP:0100658)1.86832064
138Metabolic alkalosis (HP:0200114)1.85995963
139Diaphragmatic weakness (HP:0009113)1.85306915
140Infantile muscular hypotonia (HP:0008947)1.83746851
141Hypokalemic alkalosis (HP:0001949)1.83227636
142Insomnia (HP:0100785)1.82278854
143Abnormal hemoglobin (HP:0011902)1.82258884
144Mitochondrial inheritance (HP:0001427)1.80750358
145Methylmalonic acidemia (HP:0002912)1.80300389
146Abnormality of the umbilical cord (HP:0010881)1.79945180
147Tongue fasciculations (HP:0001308)1.79761173
148Abnormal gallbladder physiology (HP:0012438)1.79554569
149Cholecystitis (HP:0001082)1.79554569
150Hypertensive crisis (HP:0100735)1.78959257
151Paralysis (HP:0003470)1.78935024
152Urinary urgency (HP:0000012)1.78410646
153Lower limb muscle weakness (HP:0007340)1.76763591
154Tetraplegia (HP:0002445)1.76555402
155Bundle branch block (HP:0011710)1.75712545
156Ileus (HP:0002595)1.75167879
157Hammertoe (HP:0001765)1.74815171
158Febrile seizures (HP:0002373)1.74001035
159Urinary incontinence (HP:0000020)1.73806696
160Bowel incontinence (HP:0002607)1.73417175
161External ophthalmoplegia (HP:0000544)1.73314846
162Stenosis of the external auditory canal (HP:0000402)1.72693504
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70745797
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70745797
165Abnormality of magnesium homeostasis (HP:0004921)1.70581702
166Epileptic encephalopathy (HP:0200134)1.69828561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.66102412
2OXSR14.14086643
3RIPK43.31544029
4EPHB13.09565228
5TESK23.05400136
6LIMK13.00567141
7MAPKAPK52.55006540
8BCR2.51243096
9MET2.50844081
10GRK52.50059006
11CDK192.50012491
12BMPR22.41564476
13EIF2AK12.34799958
14UHMK12.21985040
15PIM22.15547658
16NTRK32.13177913
17* PKN12.13092739
18CASK2.12511352
19PBK2.01963117
20FGFR22.01239231
21PNCK1.97461092
22WNK41.94333637
23CSNK1G31.86310883
24WNK11.79951685
25CSNK1A1L1.78992436
26TLK11.76810926
27PRPF4B1.74313069
28CLK11.64592068
29CDK81.62503381
30DYRK21.58007098
31DAPK11.56803053
32NEK61.56103199
33DAPK21.54065261
34SGK2231.52209472
35SGK4941.52209472
36NTRK11.50384120
37CSNK1G11.48674760
38MAPK121.47025597
39KDR1.44687186
40PDK21.38088524
41* CAMK2B1.37030457
42PAK61.36847165
43MINK11.36415347
44PLK21.35020635
45* DAPK31.34923997
46BUB11.33186061
47PHKG11.31949712
48PHKG21.31949712
49TAOK21.28267247
50MAP3K121.25173098
51CSNK1G21.22764965
52FGR1.21573155
53RAF11.20574939
54ABL21.18086108
55CAMK11.17545407
56VRK21.06343140
57ICK1.04905834
58* CAMK2D1.01911121
59MAP2K21.01063295
60MARK21.01044060
61* ROCK20.98604427
62MST40.98378818
63* CAMK2G0.97454694
64ALK0.95966702
65CDK140.95543766
66* ILK0.93077326
67MARK10.92957116
68TYRO30.87842689
69TRIB30.87820783
70CDK150.84009785
71LMTK20.82919229
72ERBB20.82585378
73MAP3K110.81203814
74PTK20.78920406
75DDR20.78830133
76CDK180.76862262
77CDK11A0.76238887
78PIK3CG0.75720197
79MAPK150.70338439
80GSK3A0.69401125
81RPS6KA50.68734028
82CDK50.68286467
83TRPM70.67570617
84PDPK10.67452323
85TESK10.67243152
86PAK30.65074213
87KSR20.64727877
88IRAK20.64619776
89PAK20.64514957
90DMPK0.64298721
91* CAMK2A0.63917798
92LATS20.63248181
93* PRKD10.62540687
94PRKCG0.60540951
95PINK10.59944013
96CDK90.59507710
97ARAF0.59474766
98TIE10.59474738
99MAPK40.58490529
100TEC0.56114008
101TNK20.54695542
102CCNB10.53343929
103PRKCQ0.53237663
104MUSK0.53050952
105CSNK1A10.52953254
106EPHA40.52136078
107MKNK10.50074735
108FYN0.49719477
109MAP3K10.48723589
110ZAP700.48602056
111EPHA30.48601922
112CSNK1D0.46128490
113PRKD30.45809068
114PRKACB0.45769935
115* PRKACG0.45738750
116* PAK10.45302575
117STK160.44430843
118* PRKCA0.44334369
119BTK0.44247750
120BMX0.44065053
121MAP2K10.44016908
122MAP3K130.43786228
123MAPK130.42284824
124PRKG20.41476551
125CSNK1E0.41189373
126MKNK20.40650466
127SRC0.40209988
128ADRBK10.39710732
129PAK40.39020187
130EPHB20.38530539
131STK110.37757976
132NTRK20.36786062
133MATK0.36481457
134NME20.35957026
135MAPKAPK30.35474287
136PIK3CA0.33762912
137* PRKG10.33017624
138EPHA20.32366915
139PRKD20.31873548
140MAPK100.28860269
141BRAF0.28608635
142GRK10.25243455
143MYLK0.24146126
144MAPK70.24015865
145ROCK10.23984964
146BLK0.23839282
147BCKDK0.23295250
148* PRKCE0.22717413
149PTK2B0.22276071
150IRAK10.22233373
151PDK10.22118771

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.14196615
2Fatty acid elongation_Homo sapiens_hsa000624.44816324
3Nitrogen metabolism_Homo sapiens_hsa009104.15291330
4Steroid biosynthesis_Homo sapiens_hsa001003.86768864
5Vitamin B6 metabolism_Homo sapiens_hsa007503.46259535
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.03426822
7Ether lipid metabolism_Homo sapiens_hsa005652.86245460
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77519155
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34101051
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32655830
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00819701
12Axon guidance_Homo sapiens_hsa043601.93733850
13Platelet activation_Homo sapiens_hsa046111.89481261
14Histidine metabolism_Homo sapiens_hsa003401.89263684
15Sulfur metabolism_Homo sapiens_hsa009201.88187120
16Oxidative phosphorylation_Homo sapiens_hsa001901.87888937
17Protein export_Homo sapiens_hsa030601.87867890
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.82964755
19Folate biosynthesis_Homo sapiens_hsa007901.81492982
20Linoleic acid metabolism_Homo sapiens_hsa005911.78281599
21Sphingolipid metabolism_Homo sapiens_hsa006001.70392175
22Arginine and proline metabolism_Homo sapiens_hsa003301.64188720
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53840704
24Long-term potentiation_Homo sapiens_hsa047201.53697834
25Parkinsons disease_Homo sapiens_hsa050121.49497396
26Amphetamine addiction_Homo sapiens_hsa050311.41705867
27Nicotine addiction_Homo sapiens_hsa050331.40720291
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39230765
29Olfactory transduction_Homo sapiens_hsa047401.28356641
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21410047
31Dopaminergic synapse_Homo sapiens_hsa047281.20489982
32Alzheimers disease_Homo sapiens_hsa050101.19062792
33Tight junction_Homo sapiens_hsa045301.19022578
34Renal cell carcinoma_Homo sapiens_hsa052111.18398117
35Arachidonic acid metabolism_Homo sapiens_hsa005901.17390258
36Calcium signaling pathway_Homo sapiens_hsa040201.16354247
37GABAergic synapse_Homo sapiens_hsa047271.15370846
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13428597
39Insulin secretion_Homo sapiens_hsa049111.12423552
40Dilated cardiomyopathy_Homo sapiens_hsa054141.11018259
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10335687
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09092415
43Glutathione metabolism_Homo sapiens_hsa004801.02755159
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01706652
45Renin secretion_Homo sapiens_hsa049241.00867129
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00764032
47Butanoate metabolism_Homo sapiens_hsa006501.00722267
48Oxytocin signaling pathway_Homo sapiens_hsa049210.98127488
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94688342
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.90605569
51Hedgehog signaling pathway_Homo sapiens_hsa043400.89546632
52Cholinergic synapse_Homo sapiens_hsa047250.88407248
53Cardiac muscle contraction_Homo sapiens_hsa042600.87140019
54Rap1 signaling pathway_Homo sapiens_hsa040150.86392659
55Glutamatergic synapse_Homo sapiens_hsa047240.84625428
56Asthma_Homo sapiens_hsa053100.84471259
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84416256
58Focal adhesion_Homo sapiens_hsa045100.84224370
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83871204
60Endocytosis_Homo sapiens_hsa041440.83578573
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81168682
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.79870379
63Long-term depression_Homo sapiens_hsa047300.78427362
64Serotonergic synapse_Homo sapiens_hsa047260.77299376
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76353802
66cAMP signaling pathway_Homo sapiens_hsa040240.75095611
67Cocaine addiction_Homo sapiens_hsa050300.74424644
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74328234
69Vibrio cholerae infection_Homo sapiens_hsa051100.73161657
70Proteasome_Homo sapiens_hsa030500.73054345
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72488056
72Morphine addiction_Homo sapiens_hsa050320.71566746
73Huntingtons disease_Homo sapiens_hsa050160.69887925
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69453155
75Mineral absorption_Homo sapiens_hsa049780.68645244
76Lysosome_Homo sapiens_hsa041420.65331827
77Ras signaling pathway_Homo sapiens_hsa040140.64912475
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64284629
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.64104344
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63582857
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60814522
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.59674837
83PPAR signaling pathway_Homo sapiens_hsa033200.59458738
84Phototransduction_Homo sapiens_hsa047440.58473256
85Vitamin digestion and absorption_Homo sapiens_hsa049770.57902201
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57883165
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55925788
88Gap junction_Homo sapiens_hsa045400.55687465
89Regulation of autophagy_Homo sapiens_hsa041400.54030787
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53596196
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.53097452
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51951232
93Prion diseases_Homo sapiens_hsa050200.51895935
94Collecting duct acid secretion_Homo sapiens_hsa049660.51136909
95Oocyte meiosis_Homo sapiens_hsa041140.50857938
96Autoimmune thyroid disease_Homo sapiens_hsa053200.49501477
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48907687
98* Vascular smooth muscle contraction_Homo sapiens_hsa042700.48550918
99Metabolic pathways_Homo sapiens_hsa011000.47595866
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47269847
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.47154173
102RNA polymerase_Homo sapiens_hsa030200.46865588
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44658055
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44524078
105Propanoate metabolism_Homo sapiens_hsa006400.44296375
106Choline metabolism in cancer_Homo sapiens_hsa052310.43508225
107Ovarian steroidogenesis_Homo sapiens_hsa049130.43485017
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41972486
109Fatty acid metabolism_Homo sapiens_hsa012120.41941886
110Glioma_Homo sapiens_hsa052140.41788545
111Pentose phosphate pathway_Homo sapiens_hsa000300.41648446
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41244338
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.40841995
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40461294
115Salivary secretion_Homo sapiens_hsa049700.40226790
116Phenylalanine metabolism_Homo sapiens_hsa003600.39809189
117Sulfur relay system_Homo sapiens_hsa041220.39789571
118Dorso-ventral axis formation_Homo sapiens_hsa043200.39495831
119Gastric acid secretion_Homo sapiens_hsa049710.38628690
120ErbB signaling pathway_Homo sapiens_hsa040120.37977501
121Retinol metabolism_Homo sapiens_hsa008300.37846959
122ECM-receptor interaction_Homo sapiens_hsa045120.37361476
123Pyruvate metabolism_Homo sapiens_hsa006200.37004329
124B cell receptor signaling pathway_Homo sapiens_hsa046620.36225029
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35925412
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35888086
127Basal cell carcinoma_Homo sapiens_hsa052170.35750334
128Peroxisome_Homo sapiens_hsa041460.35196929
129Phagosome_Homo sapiens_hsa041450.35130930
130VEGF signaling pathway_Homo sapiens_hsa043700.34002597
131Rheumatoid arthritis_Homo sapiens_hsa053230.33965794
132Chemical carcinogenesis_Homo sapiens_hsa052040.33746221
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33425042
134Circadian entrainment_Homo sapiens_hsa047130.33364915
135Melanogenesis_Homo sapiens_hsa049160.31508745
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30930441
137Tyrosine metabolism_Homo sapiens_hsa003500.30792787
138Hippo signaling pathway_Homo sapiens_hsa043900.28807253
139Pancreatic secretion_Homo sapiens_hsa049720.28219814
140Synaptic vesicle cycle_Homo sapiens_hsa047210.28182247
141beta-Alanine metabolism_Homo sapiens_hsa004100.27433090
142Malaria_Homo sapiens_hsa051440.26631810
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25514432
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23768206
145Wnt signaling pathway_Homo sapiens_hsa043100.20921107
146Arginine biosynthesis_Homo sapiens_hsa002200.18263655

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