PPP1R12C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.17955558
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17955558
3positive regulation of histone deacetylation (GO:0031065)3.92797318
4positive regulation of gamma-delta T cell activation (GO:0046645)3.59534147
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48579793
6positive thymic T cell selection (GO:0045059)3.47199298
7regulation of ARF GTPase activity (GO:0032312)3.41815944
8regulation of ARF protein signal transduction (GO:0032012)3.40378245
9regulation of gamma-delta T cell differentiation (GO:0045586)3.35112730
10protein localization to endosome (GO:0036010)3.35010419
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34329344
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32909491
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32909491
14sodium ion export (GO:0071436)3.30754197
15cytoskeletal anchoring at plasma membrane (GO:0007016)3.29576613
16negative regulation of erythrocyte differentiation (GO:0045647)3.29434502
17positive regulation of Rap GTPase activity (GO:0032854)3.28321463
18stress fiber assembly (GO:0043149)3.18710829
19regulation of T-helper 2 cell differentiation (GO:0045628)3.10667965
20negative regulation of cell size (GO:0045792)3.09864873
21mannose metabolic process (GO:0006013)3.04957536
22antigen processing and presentation of endogenous antigen (GO:0019883)3.04721032
23response to peptidoglycan (GO:0032494)3.01066580
24locomotory exploration behavior (GO:0035641)2.99682015
25regulation of gamma-delta T cell activation (GO:0046643)2.98737890
26peptidyl-lysine dimethylation (GO:0018027)2.92847116
27regulation of interleukin-12 biosynthetic process (GO:0045075)2.87234578
28activation of protein kinase A activity (GO:0034199)2.87029680
29regulation of Rap GTPase activity (GO:0032317)2.85383533
30positive regulation of receptor recycling (GO:0001921)2.84879762
31cortical actin cytoskeleton organization (GO:0030866)2.84587926
32synaptic vesicle maturation (GO:0016188)2.84423368
33response to muramyl dipeptide (GO:0032495)2.83960831
34thymic T cell selection (GO:0045061)2.83085857
35G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82635854
36negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.79094032
37positive regulation of Cdc42 GTPase activity (GO:0043089)2.79083618
38endothelial cell chemotaxis (GO:0035767)2.78475210
39positive regulation of protein deacetylation (GO:0090312)2.77520799
40germinal center formation (GO:0002467)2.75883172
41apoptotic cell clearance (GO:0043277)2.71093251
42regulation of early endosome to late endosome transport (GO:2000641)2.70842053
43regulation of leukocyte degranulation (GO:0043300)2.70669782
44apoptotic process involved in morphogenesis (GO:0060561)2.68254358
45detection of other organism (GO:0098543)2.68099735
46plasma membrane repair (GO:0001778)2.68084360
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67537438
48cell-cell junction maintenance (GO:0045217)2.67360394
49detection of bacterium (GO:0016045)2.66881635
50activation of JUN kinase activity (GO:0007257)2.65821336
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64367466
52adenosine receptor signaling pathway (GO:0001973)2.64026726
53regulation of synapse structural plasticity (GO:0051823)2.63220239
54antigen processing and presentation via MHC class Ib (GO:0002475)2.60542491
55regulation of B cell receptor signaling pathway (GO:0050855)2.60066482
56positive regulation of protein dephosphorylation (GO:0035307)2.59894330
57regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58146350
58regulation of p38MAPK cascade (GO:1900744)2.56570293
59positive T cell selection (GO:0043368)2.56047251
60adherens junction assembly (GO:0034333)2.54921783
61regulation of clathrin-mediated endocytosis (GO:2000369)2.53044686
62semaphorin-plexin signaling pathway (GO:0071526)2.49113899
63angiogenesis involved in wound healing (GO:0060055)2.47829155
64modulation by symbiont of host cellular process (GO:0044068)2.46866038
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45628524
66response to laminar fluid shear stress (GO:0034616)2.45626195
67focal adhesion assembly (GO:0048041)2.44683472
68cell-substrate adherens junction assembly (GO:0007045)2.44683472
69cell-substrate junction assembly (GO:0007044)2.44573308
70regulation of extracellular matrix disassembly (GO:0010715)2.44553674
71negative thymic T cell selection (GO:0045060)2.43135618
72negative regulation of nucleotide catabolic process (GO:0030812)2.43085522
73activation of MAPKKK activity (GO:0000185)2.42008381
74regulation of mast cell degranulation (GO:0043304)2.41661256
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41523498
76NIK/NF-kappaB signaling (GO:0038061)2.40372304
77megakaryocyte development (GO:0035855)2.38478628
78regulation of necroptotic process (GO:0060544)2.38470413
79macrophage activation involved in immune response (GO:0002281)2.38443128
80clathrin coat assembly (GO:0048268)2.37584916
81detection of external biotic stimulus (GO:0098581)2.37517786
82T cell selection (GO:0045058)2.37440629
83positive regulation of fibroblast migration (GO:0010763)2.35942913
84B cell receptor signaling pathway (GO:0050853)2.35164887
85leukocyte aggregation (GO:0070486)2.34827343
86positive regulation of B cell differentiation (GO:0045579)2.33827431
87mature B cell differentiation (GO:0002335)2.33696743
88cell communication by electrical coupling (GO:0010644)2.33509341
89negative regulation of myotube differentiation (GO:0010832)2.33284886
90coronary vasculature morphogenesis (GO:0060977)2.32834312
91regulation of regulated secretory pathway (GO:1903305)2.32313873
92regulation of interferon-beta biosynthetic process (GO:0045357)2.31952398
93cortical cytoskeleton organization (GO:0030865)2.31745533
94neutrophil activation involved in immune response (GO:0002283)2.31485298
95response to fluid shear stress (GO:0034405)2.31218079
96pre-miRNA processing (GO:0031054)2.31167958
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.31149386
98natural killer cell differentiation (GO:0001779)2.29905686
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29550278
100vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28286969
101layer formation in cerebral cortex (GO:0021819)2.27929776
102negative T cell selection (GO:0043383)2.26932330
103modulation by virus of host process (GO:0019054)2.26838477
104negative regulation of granulocyte differentiation (GO:0030853)2.26753231
105negative regulation of potassium ion transmembrane transport (GO:1901380)2.26716774
106potassium ion import (GO:0010107)2.26319432
107positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25283325
108regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.25097779
109negative regulation of interleukin-12 production (GO:0032695)2.25049821
110positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.24833912
111atrioventricular valve morphogenesis (GO:0003181)2.23734530
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23378800
113detection of molecule of bacterial origin (GO:0032490)2.22965611
114activation of Rac GTPase activity (GO:0032863)2.22404581
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.21018957
116regulation of type I interferon-mediated signaling pathway (GO:0060338)2.20999446
117positive regulation of cellular amide metabolic process (GO:0034250)2.20469167
118cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.20197793
119signal complex assembly (GO:0007172)2.19977948
120adaptation of signaling pathway (GO:0023058)2.18239895
121negative regulation of type 2 immune response (GO:0002829)2.18204086
122negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.18093618
123regulation of necrotic cell death (GO:0010939)2.17991334
124NLS-bearing protein import into nucleus (GO:0006607)2.17564535
125negative regulation of cardiac muscle tissue growth (GO:0055022)2.17348105
126negative regulation of heart growth (GO:0061117)2.17348105
127pinocytosis (GO:0006907)2.16999082
128cell volume homeostasis (GO:0006884)2.16596383
129cAMP biosynthetic process (GO:0006171)2.16240836
130receptor catabolic process (GO:0032801)2.16155335
131synaptic vesicle docking involved in exocytosis (GO:0016081)2.16112402
132regulation of macrophage cytokine production (GO:0010935)2.15837884
133barbed-end actin filament capping (GO:0051016)2.15799097
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.15381954
135cellular potassium ion homeostasis (GO:0030007)2.15362304
136regulation of lipid kinase activity (GO:0043550)2.15218690
137establishment of protein localization to Golgi (GO:0072600)2.14954142
138positive regulation of p38MAPK cascade (GO:1900745)2.14519047
139cardiac myofibril assembly (GO:0055003)2.13576448
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.13527757
141modulation by symbiont of host immune response (GO:0052553)2.13527757
142positive regulation by symbiont of host defense response (GO:0052509)2.13527757
143modulation by symbiont of host defense response (GO:0052031)2.13527757
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13527757
145modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13527757
146regulation of type 2 immune response (GO:0002828)2.13356065
147positive regulation of blood vessel endothelial cell migration (GO:0043536)2.13164117
148regulation of NFAT protein import into nucleus (GO:0051532)2.13088520
149negative regulation of necroptotic process (GO:0060546)2.11251788
150positive regulation of myotube differentiation (GO:0010831)2.08826403
151negative regulation of fatty acid transport (GO:2000192)2.08594575
152protein targeting to plasma membrane (GO:0072661)2.08254370
153cellular response to thyroid hormone stimulus (GO:0097067)2.07883428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37167359
2MYC_22102868_ChIP-Seq_BL_Human3.15809949
3KDM2B_26808549_Chip-Seq_SUP-B15_Human3.08164867
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97512103
5* KDM2B_26808549_Chip-Seq_DND41_Human2.88027998
6VDR_21846776_ChIP-Seq_THP-1_Human2.78920670
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.78297901
8TCF7_22412390_ChIP-Seq_EML_Mouse2.72278326
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57506536
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.50454604
11LXR_22292898_ChIP-Seq_THP-1_Human2.38131615
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.37934264
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.37714537
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.09591544
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05710597
16SCL_19346495_ChIP-Seq_HPC-7_Human2.03701079
17MAF_26560356_Chip-Seq_TH1_Human2.03361436
18* KDM2B_26808549_Chip-Seq_K562_Human2.02782096
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.01471470
20* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96764371
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93758318
22SPI1_23127762_ChIP-Seq_K562_Human1.92176671
23UTX_26944678_Chip-Seq_JUKART_Human1.84813290
24VDR_24763502_ChIP-Seq_THP-1_Human1.82105263
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79949823
26GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79864264
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71717606
28* RARB_27405468_Chip-Seq_BRAIN_Mouse1.71567494
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69811330
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69548324
31DROSHA_22980978_ChIP-Seq_HELA_Human1.67275089
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65531360
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65157137
34GATA1_19941826_ChIP-Seq_K562_Human1.62043808
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61781500
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59070453
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58433865
38* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54961008
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.54956784
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.54921670
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.54691320
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54454534
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54100297
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53456620
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52514072
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52283294
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50843707
48ZNF263_19887448_ChIP-Seq_K562_Human1.50573599
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49956364
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.49942090
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49844372
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49080249
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49075349
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48723765
55* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47637515
56RUNX_20019798_ChIP-Seq_JUKART_Human1.46039939
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44539340
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44467647
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43519758
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.42646299
61* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40109868
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37831712
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.34192994
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.33553156
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31770183
66CLOCK_20551151_ChIP-Seq_293T_Human1.30539586
67CREB1_26743006_Chip-Seq_LNCaP_Human1.28685894
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27716392
69P68_20966046_ChIP-Seq_HELA_Human1.27492260
70* MAF_26560356_Chip-Seq_TH2_Human1.27377653
71CTCF_27219007_Chip-Seq_Bcells_Human1.27325987
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25046013
73* NCOR1_26117541_ChIP-Seq_K562_Human1.24942940
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.24790156
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22392234
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21379518
77MYB_26560356_Chip-Seq_TH1_Human1.20968454
78* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20941908
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20699518
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20537626
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17448056
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17071601
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16500407
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.16381066
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.16381066
86MYB_26560356_Chip-Seq_TH2_Human1.15582389
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15505951
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.15260405
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14677634
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13424270
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.12460966
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12285796
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.11392789
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.10938899
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10006038
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09502105
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09479409
98SMC4_20622854_ChIP-Seq_HELA_Human1.09397280
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09185497
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09036905
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08200704
102TP63_22573176_ChIP-Seq_HFKS_Human1.07370311
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07330577
104GATA2_19941826_ChIP-Seq_K562_Human1.06825391
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06649391
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05953250
107ATF3_27146783_Chip-Seq_COLON_Human1.04494328
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02420058
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01657735
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01656571
111* BCOR_27268052_Chip-Seq_Bcells_Human1.01330665
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01068904
113TP53_22127205_ChIP-Seq_IMR90_Human1.00257676
114GATA1_22025678_ChIP-Seq_K562_Human0.99521248
115SA1_27219007_Chip-Seq_Bcells_Human0.98996742
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98752266
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98141596
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.97664888
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97661982
120TET1_21490601_ChIP-Seq_MESCs_Mouse0.97411452
121* BCL6_27268052_Chip-Seq_Bcells_Human0.96308564
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95490419
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92966407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.68313368
2MP0003303_peritoneal_inflammation3.56899256
3MP0004859_abnormal_synaptic_plasticity3.09385502
4MP0003300_gastrointestinal_ulcer2.92208705
5MP0003705_abnormal_hypodermis_morpholog2.75853828
6MP0000569_abnormal_digit_pigmentation2.69110044
7MP0008961_abnormal_basal_metabolism2.67058200
8MP0009278_abnormal_bone_marrow2.49282248
9MP0008260_abnormal_autophagy2.25465975
10MP0005451_abnormal_body_composition2.18489652
11MP0003566_abnormal_cell_adhesion2.02113365
12MP0003724_increased_susceptibility_to2.01777747
13MP0004130_abnormal_muscle_cell1.97528893
14MP0004084_abnormal_cardiac_muscle1.97413489
15MP0005167_abnormal_blood-brain_barrier1.95575112
16MP0003172_abnormal_lysosome_physiology1.93019672
17MP0000751_myopathy1.91416987
18MP0000685_abnormal_immune_system1.88977674
19MP0002166_altered_tumor_susceptibility1.87245444
20MP0005058_abnormal_lysosome_morphology1.84894630
21MP0004808_abnormal_hematopoietic_stem1.75881494
22MP0001533_abnormal_skeleton_physiology1.71173738
23MP0001958_emphysema1.69550636
24MP0003045_fibrosis1.67145617
25MP0004185_abnormal_adipocyte_glucose1.66780564
26MP0010352_gastrointestinal_tract_polyps1.66364181
27MP0005464_abnormal_platelet_physiology1.65969191
28MP0003075_altered_response_to1.64041454
29MP0005409_darkened_coat_color1.62387618
30MP0005397_hematopoietic_system_phenotyp1.61626908
31MP0001545_abnormal_hematopoietic_system1.61626908
32MP0003191_abnormal_cellular_cholesterol1.50512865
33MP0005076_abnormal_cell_differentiation1.48771333
34MP0010234_abnormal_vibrissa_follicle1.45796413
35MP0009780_abnormal_chondrocyte_physiolo1.45794031
36MP0003283_abnormal_digestive_organ1.45504916
37MP0002909_abnormal_adrenal_gland1.45267186
38MP0002396_abnormal_hematopoietic_system1.40945975
39MP0001835_abnormal_antigen_presentation1.40660740
40MP0002933_joint_inflammation1.40629074
41MP0000858_altered_metastatic_potential1.40072216
42MP0003453_abnormal_keratinocyte_physiol1.38296308
43MP0003091_abnormal_cell_migration1.37386763
44MP0001348_abnormal_lacrimal_gland1.34868230
45MP0000678_abnormal_parathyroid_gland1.33849922
46MP0001800_abnormal_humoral_immune1.33576910
47MP0006082_CNS_inflammation1.32489476
48MP0004036_abnormal_muscle_relaxation1.30928917
49MP0010630_abnormal_cardiac_muscle1.30162724
50MP0004858_abnormal_nervous_system1.29869819
51MP0004947_skin_inflammation1.28707223
52MP0004087_abnormal_muscle_fiber1.27955824
53MP0001790_abnormal_immune_system1.26937262
54MP0005387_immune_system_phenotype1.26937262
55MP0003436_decreased_susceptibility_to1.26205796
56MP0003279_aneurysm1.24945114
57MP0003879_abnormal_hair_cell1.24364234
58MP0005666_abnormal_adipose_tissue1.23481547
59MP0003828_pulmonary_edema1.22709798
60MP0010307_abnormal_tumor_latency1.21367119
61MP0002452_abnormal_antigen_presenting1.20617059
62MP0002822_catalepsy1.17733390
63MP0000604_amyloidosis1.17720039
64MP0003183_abnormal_peptide_metabolism1.17314574
65MP0002398_abnormal_bone_marrow1.17001549
66MP0005623_abnormal_meninges_morphology1.16706163
67MP0003635_abnormal_synaptic_transmissio1.16661398
68MP0002006_tumorigenesis1.16641937
69MP0000343_altered_response_to1.16367590
70MP0002837_dystrophic_cardiac_calcinosis1.15287589
71MP0003866_abnormal_defecation1.13787321
72MP0005375_adipose_tissue_phenotype1.12778386
73MP0002420_abnormal_adaptive_immunity1.12664002
74MP0009785_altered_susceptibility_to1.12539239
75MP0001819_abnormal_immune_cell1.10821168
76MP0001873_stomach_inflammation1.09388413
77MP0005023_abnormal_wound_healing1.08532020
78MP0000747_muscle_weakness1.07943829
79MP0002723_abnormal_immune_serum1.06401643
80MP0002249_abnormal_larynx_morphology1.06345071
81MP0005390_skeleton_phenotype1.06135222
82MP0002419_abnormal_innate_immunity1.05712830
83MP0000465_gastrointestinal_hemorrhage1.04124334
84MP0005000_abnormal_immune_tolerance1.03000404
85MP0006138_congestive_heart_failure1.02008966
86MP0003329_amyloid_beta_deposits1.00265186
87MP0005330_cardiomyopathy0.99769674
88MP0002089_abnormal_postnatal_growth/wei0.99742987
89MP0001851_eye_inflammation0.99730467
90MP0008874_decreased_physiological_sensi0.98530742
91MP0005166_decreased_susceptibility_to0.98462289
92MP0009840_abnormal_foam_cell0.97683540
93MP0008438_abnormal_cutaneous_collagen0.97540844
94MP0002877_abnormal_melanocyte_morpholog0.97532376
95MP0008569_lethality_at_weaning0.97344818
96MP0002148_abnormal_hypersensitivity_rea0.96966961
97MP0000689_abnormal_spleen_morphology0.95792178
98MP0002722_abnormal_immune_system0.95601233
99MP0000703_abnormal_thymus_morphology0.94603217
100MP0000716_abnormal_immune_system0.94116696
101MP0000733_abnormal_muscle_development0.93484023
102MP0002405_respiratory_system_inflammati0.93045097
103MP0009333_abnormal_splenocyte_physiolog0.93005871
104MP0008004_abnormal_stomach_pH0.91674709
105MP0001544_abnormal_cardiovascular_syste0.90704916
106MP0005385_cardiovascular_system_phenoty0.90704916
107MP0003448_altered_tumor_morphology0.87058339
108MP0000003_abnormal_adipose_tissue0.85527609
109MP0001845_abnormal_inflammatory_respons0.85299779
110MP0005671_abnormal_response_to0.84742561
111MP0005025_abnormal_response_to0.84372320
112MP0003763_abnormal_thymus_physiology0.83903749
113MP0002254_reproductive_system_inflammat0.83875444
114MP0003690_abnormal_glial_cell0.83645065
115MP0004484_altered_response_of0.83503776
116MP0000767_abnormal_smooth_muscle0.82768230
117MP0000920_abnormal_myelination0.82751258
118MP0010155_abnormal_intestine_physiology0.82365656
119MP0010368_abnormal_lymphatic_system0.82105931
120MP0002998_abnormal_bone_remodeling0.81922034
121MP0001849_ear_inflammation0.80819817
122MP0003634_abnormal_glial_cell0.80021746
123MP0002429_abnormal_blood_cell0.79718721
124MP0002925_abnormal_cardiovascular_devel0.79610555
125MP0005174_abnormal_tail_pigmentation0.79526902
126MP0005670_abnormal_white_adipose0.79503879
127MP0002106_abnormal_muscle_physiology0.77386819
128MP0000249_abnormal_blood_vessel0.77192662
129MP0000759_abnormal_skeletal_muscle0.76798114
130MP0009384_cardiac_valve_regurgitation0.75345135

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.37863866
2Obstructive sleep apnea (HP:0002870)3.63459320
3Hyperacusis (HP:0010780)3.21510624
4Hemiplegia (HP:0002301)2.78628475
5Abnormality of the nasal mucosa (HP:0000433)2.76465711
6Aortic aneurysm (HP:0004942)2.74955851
7Distal upper limb amyotrophy (HP:0007149)2.71244455
8Upper limb amyotrophy (HP:0009129)2.71244455
9Broad face (HP:0000283)2.70251708
10Hematochezia (HP:0002573)2.67548933
11Dysmetric saccades (HP:0000641)2.64945122
12Broad metatarsal (HP:0001783)2.51542079
13Abnormality of macrophages (HP:0004311)2.51378150
14Distal lower limb muscle weakness (HP:0009053)2.47694303
15Aneurysm (HP:0002617)2.47081354
16Increased cerebral lipofuscin (HP:0011813)2.46582296
17Thin bony cortex (HP:0002753)2.46395397
18Cervical subluxation (HP:0003308)2.45880040
19Annular pancreas (HP:0001734)2.42770584
20Colitis (HP:0002583)2.40113940
21Mitral valve prolapse (HP:0001634)2.39175409
22Nasal polyposis (HP:0100582)2.37465244
23Polycythemia (HP:0001901)2.35316079
24Macroorchidism (HP:0000053)2.34771344
25Premature rupture of membranes (HP:0001788)2.29863482
26Bundle branch block (HP:0011710)2.29244794
27Hand muscle atrophy (HP:0009130)2.27424310
28Gingivitis (HP:0000230)2.25594960
29Supranuclear gaze palsy (HP:0000605)2.22181661
30Striae distensae (HP:0001065)2.21733625
31Systemic lupus erythematosus (HP:0002725)2.21258735
32Lower limb amyotrophy (HP:0007210)2.21146916
33Long toe (HP:0010511)2.20709103
34Asymmetric septal hypertrophy (HP:0001670)2.19914903
35Insomnia (HP:0100785)2.19376413
36Papilledema (HP:0001085)2.19328378
37Increased density of long bones (HP:0006392)2.19324641
38Spontaneous hematomas (HP:0007420)2.19188364
39Axonal loss (HP:0003447)2.18822056
40Frequent falls (HP:0002359)2.17803189
41Vertebral compression fractures (HP:0002953)2.17674796
42Sudden death (HP:0001699)2.16978359
43Rapidly progressive (HP:0003678)2.16504165
44Neurofibrillary tangles (HP:0002185)2.15937539
45Visual hallucinations (HP:0002367)2.15701811
46Abnormality of the fingertips (HP:0001211)2.15370827
47Difficulty running (HP:0009046)2.15227143
48Eczematoid dermatitis (HP:0000976)2.14322133
49Abnormality of the lower motor neuron (HP:0002366)2.13659443
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13528306
51Abnormality of polysaccharide metabolism (HP:0011012)2.13528306
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13528306
53Hemorrhage of the eye (HP:0011885)2.12866390
54Pointed chin (HP:0000307)2.12139997
55Stridor (HP:0010307)2.10481499
56Urinary glycosaminoglycan excretion (HP:0003541)2.10272397
57Mucopolysacchariduria (HP:0008155)2.10272397
58Shallow orbits (HP:0000586)2.09871790
59Gastrointestinal inflammation (HP:0004386)2.08207216
60Myositis (HP:0100614)2.08198175
61Increased connective tissue (HP:0009025)2.07122577
62Nuclear cataract (HP:0100018)2.06831802
63Cellulitis (HP:0100658)2.06067096
64Recurrent gram-negative bacterial infections (HP:0005420)2.05606735
65Abnormality of liposaccharide metabolism (HP:0010968)2.05025473
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.05025473
67Abnormality of glycolipid metabolism (HP:0010969)2.05025473
68Abnormality of skeletal muscle fiber size (HP:0012084)2.04811988
69Increased IgE level (HP:0003212)2.04178940
70Cerebral inclusion bodies (HP:0100314)2.03795579
71Inflammation of the large intestine (HP:0002037)2.03455358
72Mitral regurgitation (HP:0001653)2.03006661
73Distal lower limb amyotrophy (HP:0008944)2.02546689
74Facial diplegia (HP:0001349)2.01793433
75Dilatation of the ascending aorta (HP:0005111)2.00482502
76Hyporeflexia of lower limbs (HP:0002600)1.99797229
77Malnutrition (HP:0004395)1.98817750
78Amyloidosis (HP:0011034)1.96317634
79Resting tremor (HP:0002322)1.93815910
80J-shaped sella turcica (HP:0002680)1.92464261
81Centrally nucleated skeletal muscle fibers (HP:0003687)1.92087802
82Achilles tendon contracture (HP:0001771)1.91817062
83Mildly elevated creatine phosphokinase (HP:0008180)1.90675904
84Enlarged penis (HP:0000040)1.90295707
85Absent frontal sinuses (HP:0002688)1.89765125
86Neuronal loss in central nervous system (HP:0002529)1.89663967
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.89578843
88Ulnar bowing (HP:0003031)1.89492693
89Neoplasm of the heart (HP:0100544)1.88262763
90Aortic dissection (HP:0002647)1.87946448
91Hypertriglyceridemia (HP:0002155)1.87927729
92Segmental peripheral demyelination/remyelination (HP:0003481)1.87683803
93Elfin facies (HP:0004428)1.87045546
94Lymphangioma (HP:0100764)1.86800614
95Peritonitis (HP:0002586)1.86723884
96Papilloma (HP:0012740)1.86163355
97Verrucae (HP:0200043)1.86163355
98Chronic obstructive pulmonary disease (HP:0006510)1.85582317
99Obstructive lung disease (HP:0006536)1.85582317
100Prolonged bleeding time (HP:0003010)1.84968680
101Difficulty climbing stairs (HP:0003551)1.84041881
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83755562
103Metaphyseal cupping (HP:0003021)1.82204763
104Recurrent abscess formation (HP:0002722)1.82128575
105Orchitis (HP:0100796)1.81942263
106Ventricular fibrillation (HP:0001663)1.81055353
107Apathy (HP:0000741)1.81053194
108Gastrointestinal infarctions (HP:0005244)1.80934581
109Joint stiffness (HP:0001387)1.80912695
110Slow saccadic eye movements (HP:0000514)1.80653750
111Bowel diverticulosis (HP:0005222)1.80537091
112Impaired platelet aggregation (HP:0003540)1.79898088
113Abnormal platelet function (HP:0011869)1.79898088
114Fragile skin (HP:0001030)1.79659646
115Interstitial pulmonary disease (HP:0006530)1.79274153
116Abnormality of complement system (HP:0005339)1.78745559
117Biconcave vertebral bodies (HP:0004586)1.78690731
118Global brain atrophy (HP:0002283)1.78325421
119Heterotopia (HP:0002282)1.77937405
120Vertebral arch anomaly (HP:0008438)1.76905697
121Abnormality of the thoracic spine (HP:0100711)1.76805982
122Genu recurvatum (HP:0002816)1.76722548
123Increased variability in muscle fiber diameter (HP:0003557)1.76451868
124Thoracic kyphosis (HP:0002942)1.76237255
125Bicuspid aortic valve (HP:0001647)1.76192796
126Urinary urgency (HP:0000012)1.74843909
127Easy fatigability (HP:0003388)1.74706736
128Recurrent fungal infections (HP:0002841)1.74655153
129Muscle fiber splitting (HP:0003555)1.73494674
130Disproportionate tall stature (HP:0001519)1.72910144
131Blue sclerae (HP:0000592)1.72652040
132Chronic otitis media (HP:0000389)1.72068111
133Dysostosis multiplex (HP:0000943)1.71850742
134Spinal rigidity (HP:0003306)1.71414303
135Protrusio acetabuli (HP:0003179)1.70784759
136Hemangiomatosis (HP:0007461)1.70606220
137Gastrointestinal stroma tumor (HP:0100723)1.69615469
138Emphysema (HP:0002097)1.68727098
139Onion bulb formation (HP:0003383)1.68337984
140Atrophic scars (HP:0001075)1.68172891
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68172564
142Arterial tortuosity (HP:0005116)1.67197810
143Abnormality of the Achilles tendon (HP:0005109)1.66215730
144Mediastinal lymphadenopathy (HP:0100721)1.66177103
145Visceral angiomatosis (HP:0100761)1.66055247
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64902627
147Diminished motivation (HP:0000745)1.64895890
148Polygenic inheritance (HP:0010982)1.64664279
149Asymmetry of the thorax (HP:0001555)1.64268812
150Gastrointestinal dysmotility (HP:0002579)1.63575143
151Increased CSF protein (HP:0002922)1.63221644
152Hypercortisolism (HP:0001578)1.61846043
153Atrioventricular block (HP:0001678)1.61656157
154Recurrent bacterial skin infections (HP:0005406)1.61373019
155Loss of speech (HP:0002371)1.61201068
156Recurrent viral infections (HP:0004429)1.59750898
157Urinary bladder sphincter dysfunction (HP:0002839)1.59363078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.72266777
2PKN23.49295127
3PRPF4B3.46484612
4EEF2K2.73117936
5TTN2.58121314
6SIK22.41459002
7MAP4K12.33133177
8MAP3K102.04306507
9RIPK11.97777888
10SMG11.92468444
11RIPK41.84787596
12TGFBR21.73727690
13IRAK31.72811407
14MAP3K111.68125554
15CAMK1G1.64902095
16MAP2K31.59044581
17KSR21.55113476
18CAMK1D1.54677230
19PTK61.54631103
20DMPK1.52751362
21CAMKK11.51603134
22MAP3K91.51014044
23PRKD31.48309009
24ALK1.46600613
25ERN11.45336360
26PRKCH1.44699028
27MAP3K71.43056698
28BLK1.41541166
29TAOK11.40985081
30TESK11.38278881
31FES1.35343698
32TAOK21.35035925
33DDR21.33557568
34DAPK21.27427932
35TYK21.24696425
36PRKD21.23909326
37GRK61.20579100
38CDK121.19503321
39HCK1.16829050
40PDGFRA1.14206955
41JAK11.14006112
42FGFR31.12003137
43MAP3K61.11755528
44RET1.11750922
45IRAK41.10631212
46KIT1.09503308
47EPHB11.08708295
48ICK1.07402337
49LRRK21.06272959
50TYRO31.03118869
51BMX0.99601470
52MAP3K130.98252199
53LMTK20.96262435
54PAK60.95365258
55ZAP700.94946197
56PDK10.94536150
57PTK2B0.92992414
58TBK10.92699539
59MARK20.91699240
60RPS6KL10.88921447
61SCYL20.85740430
62STK380.85687741
63JAK20.85123888
64TNK20.84984852
65SIK10.84827396
66SGK30.84042053
67PDPK10.80577252
68FGFR40.78221107
69MAP3K140.77739862
70JAK30.77690962
71PAK20.76328847
72IRAK20.74151883
73EPHA40.73802015
74PRKD10.73787211
75MTOR0.73616877
76CAMK40.73577424
77PRKG20.73448693
78STK110.72633989
79SYK0.72291683
80NTRK30.72245166
81ARAF0.70461727
82MYLK0.70458788
83TIE10.69037692
84PDGFRB0.68059650
85CSF1R0.66713385
86CDC42BPA0.66540443
87MAPK70.66182528
88STK100.65141861
89SIK30.65124822
90CSK0.65000541
91BTK0.64643673
92RPS6KA20.64413040
93PTK20.64222247
94FGR0.61662980
95ITK0.59887471
96NEK20.59441686
97MAP3K10.59006969
98PAK40.59003061
99MAP3K20.58278161
100CAMK10.57067180
101MAPKAPK30.56493850
102NME20.55102826
103DAPK10.53440464
104CDK60.52231684
105MOS0.52180627
106MARK30.49635845
107KDR0.49554983
108MAPK40.49552717
109DAPK30.49544615
110MAP2K60.49406241
111CDK40.49382807
112MST1R0.49157778
113NTRK10.48410022
114HIPK20.47987283
115INSRR0.47019925
116UHMK10.46973365
117MAPK120.46298825
118IKBKE0.46049050
119LCK0.45624427
120MAP2K20.44790546
121MAPK110.44350318
122ILK0.43540957
123CDK50.43405479
124CAMKK20.43328857
125LATS20.43293431
126FYN0.41570974
127MAP3K30.41201202
128DYRK1B0.41119303
129RPS6KA60.40766947
130RPS6KC10.39455535

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.52547582
2B cell receptor signaling pathway_Homo sapiens_hsa046621.78846079
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70819647
4Osteoclast differentiation_Homo sapiens_hsa043801.62144601
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51226453
6Chronic myeloid leukemia_Homo sapiens_hsa052201.50660202
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48477308
8VEGF signaling pathway_Homo sapiens_hsa043701.42819520
9Olfactory transduction_Homo sapiens_hsa047401.42389165
10Neurotrophin signaling pathway_Homo sapiens_hsa047221.41109130
11Dorso-ventral axis formation_Homo sapiens_hsa043201.36697079
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35018094
13Platelet activation_Homo sapiens_hsa046111.34114949
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33544727
15Type II diabetes mellitus_Homo sapiens_hsa049301.32473489
16Non-small cell lung cancer_Homo sapiens_hsa052231.30896715
17Glioma_Homo sapiens_hsa052141.30642742
18Long-term potentiation_Homo sapiens_hsa047201.29932508
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29931383
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29528187
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28967162
22Gastric acid secretion_Homo sapiens_hsa049711.28379283
23mTOR signaling pathway_Homo sapiens_hsa041501.28336216
24Prion diseases_Homo sapiens_hsa050201.26561536
25Dilated cardiomyopathy_Homo sapiens_hsa054141.26366441
26Estrogen signaling pathway_Homo sapiens_hsa049151.24981530
27Renin secretion_Homo sapiens_hsa049241.23795908
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23372092
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22214587
30Staphylococcus aureus infection_Homo sapiens_hsa051501.18399565
31Acute myeloid leukemia_Homo sapiens_hsa052211.17006826
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14772567
33Phospholipase D signaling pathway_Homo sapiens_hsa040721.14412586
34Leishmaniasis_Homo sapiens_hsa051401.13163522
35GnRH signaling pathway_Homo sapiens_hsa049121.12846253
36* Oxytocin signaling pathway_Homo sapiens_hsa049211.12071396
37Salivary secretion_Homo sapiens_hsa049701.11722413
38Nitrogen metabolism_Homo sapiens_hsa009101.09121890
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08241338
40Malaria_Homo sapiens_hsa051441.07198468
41Insulin resistance_Homo sapiens_hsa049311.06883737
42Chemokine signaling pathway_Homo sapiens_hsa040621.06574520
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05427900
44T cell receptor signaling pathway_Homo sapiens_hsa046601.05009914
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04253740
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03896590
47Toxoplasmosis_Homo sapiens_hsa051451.02360008
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02098183
49Bladder cancer_Homo sapiens_hsa052191.02014853
50Circadian entrainment_Homo sapiens_hsa047131.00327075
51* Focal adhesion_Homo sapiens_hsa045100.99107069
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.99013650
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98972386
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.98191666
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.97621040
56Endocytosis_Homo sapiens_hsa041440.96708420
57Insulin signaling pathway_Homo sapiens_hsa049100.94454193
58Morphine addiction_Homo sapiens_hsa050320.93690596
59Amoebiasis_Homo sapiens_hsa051460.93241583
60Influenza A_Homo sapiens_hsa051640.92808248
61Cholinergic synapse_Homo sapiens_hsa047250.92648303
62Pertussis_Homo sapiens_hsa051330.91244170
63* Proteoglycans in cancer_Homo sapiens_hsa052050.90988790
64cAMP signaling pathway_Homo sapiens_hsa040240.89990281
65Notch signaling pathway_Homo sapiens_hsa043300.88838736
66Pancreatic cancer_Homo sapiens_hsa052120.88165408
67MAPK signaling pathway_Homo sapiens_hsa040100.87593779
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87269423
69Rap1 signaling pathway_Homo sapiens_hsa040150.87247138
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.86728469
71Synaptic vesicle cycle_Homo sapiens_hsa047210.86561363
72Gap junction_Homo sapiens_hsa045400.85820939
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85730098
74Hepatitis C_Homo sapiens_hsa051600.85279556
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85160432
76HIF-1 signaling pathway_Homo sapiens_hsa040660.84922738
77Endometrial cancer_Homo sapiens_hsa052130.84543746
78Tuberculosis_Homo sapiens_hsa051520.84143127
79Prolactin signaling pathway_Homo sapiens_hsa049170.84132371
80Renal cell carcinoma_Homo sapiens_hsa052110.84038247
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.83925702
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82744640
83Glutamatergic synapse_Homo sapiens_hsa047240.81885868
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81799538
85Small cell lung cancer_Homo sapiens_hsa052220.80111119
86Dopaminergic synapse_Homo sapiens_hsa047280.79441526
87* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79348514
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77012959
89Calcium signaling pathway_Homo sapiens_hsa040200.76527977
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76042260
91Lysine degradation_Homo sapiens_hsa003100.75685060
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73892064
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73751752
94Inositol phosphate metabolism_Homo sapiens_hsa005620.73152933
95Choline metabolism in cancer_Homo sapiens_hsa052310.72907898
96Amphetamine addiction_Homo sapiens_hsa050310.72332532
97Viral myocarditis_Homo sapiens_hsa054160.72093199
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71908836
99Glucagon signaling pathway_Homo sapiens_hsa049220.70946301
100* Vascular smooth muscle contraction_Homo sapiens_hsa042700.70720248
101Allograft rejection_Homo sapiens_hsa053300.70047056
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69857161
103Insulin secretion_Homo sapiens_hsa049110.69270103
104Phagosome_Homo sapiens_hsa041450.69019490
105Salmonella infection_Homo sapiens_hsa051320.68546053
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.68335952
107Lysosome_Homo sapiens_hsa041420.67850070
108TNF signaling pathway_Homo sapiens_hsa046680.67573718
109Graft-versus-host disease_Homo sapiens_hsa053320.67104234
110Shigellosis_Homo sapiens_hsa051310.66965130
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66697395
112Cocaine addiction_Homo sapiens_hsa050300.66301600
113Colorectal cancer_Homo sapiens_hsa052100.65850619
114ErbB signaling pathway_Homo sapiens_hsa040120.65341661
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63784984
116Apoptosis_Homo sapiens_hsa042100.63697804
117Primary immunodeficiency_Homo sapiens_hsa053400.63471994
118Hepatitis B_Homo sapiens_hsa051610.62930410
119Measles_Homo sapiens_hsa051620.60471046
120AMPK signaling pathway_Homo sapiens_hsa041520.60195938
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59720915
122Autoimmune thyroid disease_Homo sapiens_hsa053200.59164873
123ECM-receptor interaction_Homo sapiens_hsa045120.57489935
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.56881519
125HTLV-I infection_Homo sapiens_hsa051660.56464270
126African trypanosomiasis_Homo sapiens_hsa051430.56092564
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.54552092
128Herpes simplex infection_Homo sapiens_hsa051680.52793326

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