PPP1CC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.87650739
2DNA unwinding involved in DNA replication (GO:0006268)4.83804070
3nuclear pore organization (GO:0006999)4.83062336
4protein localization to chromosome, centromeric region (GO:0071459)4.69876501
5establishment of integrated proviral latency (GO:0075713)4.65217037
6protein localization to kinetochore (GO:0034501)4.59904402
7mitotic sister chromatid cohesion (GO:0007064)4.40301410
8DNA replication-dependent nucleosome organization (GO:0034723)4.16592368
9DNA replication-dependent nucleosome assembly (GO:0006335)4.16592368
10mitotic nuclear envelope disassembly (GO:0007077)4.12573021
11mitotic chromosome condensation (GO:0007076)4.06494046
12regulation of histone H3-K9 methylation (GO:0051570)4.00498322
13DNA topological change (GO:0006265)3.99845159
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.97355824
15heterochromatin organization (GO:0070828)3.95547357
16nuclear envelope disassembly (GO:0051081)3.92591190
17membrane disassembly (GO:0030397)3.92591190
18DNA replication initiation (GO:0006270)3.82747917
19chromosome condensation (GO:0030261)3.80820656
20DNA strand elongation involved in DNA replication (GO:0006271)3.79049501
21regulation of RNA export from nucleus (GO:0046831)3.70764664
22negative regulation of histone methylation (GO:0031061)3.68791043
23pre-miRNA processing (GO:0031054)3.67962924
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60975649
25regulation of sister chromatid cohesion (GO:0007063)3.58768563
26sister chromatid segregation (GO:0000819)3.58335619
27cellular protein complex localization (GO:0034629)3.57747222
28CENP-A containing nucleosome assembly (GO:0034080)3.57412396
29mitotic metaphase plate congression (GO:0007080)3.56272221
30pore complex assembly (GO:0046931)3.55517246
31chromatin assembly (GO:0031497)3.54932847
32DNA strand elongation (GO:0022616)3.53862243
33ribosomal large subunit biogenesis (GO:0042273)3.53603224
34IMP metabolic process (GO:0046040)3.52266260
35mitotic sister chromatid segregation (GO:0000070)3.49870653
36peptidyl-lysine dimethylation (GO:0018027)3.47218278
37DNA packaging (GO:0006323)3.44150269
38protein localization to chromosome (GO:0034502)3.44088311
39positive regulation of chromosome segregation (GO:0051984)3.42973448
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41474504
41regulation of translational termination (GO:0006449)3.41379931
42formation of translation preinitiation complex (GO:0001731)3.40542954
43DNA duplex unwinding (GO:0032508)3.40115499
44regulation of spindle organization (GO:0090224)3.38678135
45DNA geometric change (GO:0032392)3.38130938
46negative regulation of RNA splicing (GO:0033119)3.37535922
47paraxial mesoderm development (GO:0048339)3.37108761
48ribosomal small subunit biogenesis (GO:0042274)3.35516863
49translational termination (GO:0006415)3.35137853
50negative regulation of chromosome segregation (GO:0051985)3.34991053
51viral transcription (GO:0019083)3.34656132
52monoubiquitinated protein deubiquitination (GO:0035520)3.34150259
53chromatin assembly or disassembly (GO:0006333)3.30864692
54synaptonemal complex assembly (GO:0007130)3.30214299
55maturation of SSU-rRNA (GO:0030490)3.30074217
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29080423
57establishment of viral latency (GO:0019043)3.28754991
58DNA replication checkpoint (GO:0000076)3.28054146
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.26643350
60negative regulation of sister chromatid segregation (GO:0033046)3.26643350
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26643350
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26643350
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26643350
64translesion synthesis (GO:0019985)3.25718130
65purine nucleobase biosynthetic process (GO:0009113)3.25167943
66gene silencing by RNA (GO:0031047)3.22149254
67regulation of chromosome segregation (GO:0051983)3.21269977
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19402858
69nuclear envelope organization (GO:0006998)3.19112657
70DNA conformation change (GO:0071103)3.19087128
71regulation of translational fidelity (GO:0006450)3.18931547
72mRNA stabilization (GO:0048255)3.18270638
73RNA stabilization (GO:0043489)3.18270638
74negative regulation of DNA repair (GO:0045738)3.17788900
75regulation of centriole replication (GO:0046599)3.17012723
76regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16246255
77regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.16246255
78mitotic spindle checkpoint (GO:0071174)3.14999828
79spindle checkpoint (GO:0031577)3.14265799
80translational elongation (GO:0006414)3.13502710
81translational initiation (GO:0006413)3.13247682
82regulation of sister chromatid segregation (GO:0033045)3.11763080
83regulation of mitotic sister chromatid separation (GO:0010965)3.11763080
84regulation of mitotic sister chromatid segregation (GO:0033047)3.11763080
85metaphase plate congression (GO:0051310)3.10671448
86histone exchange (GO:0043486)3.09966827
87ribosomal small subunit assembly (GO:0000028)3.09028213
88histone H2A monoubiquitination (GO:0035518)3.06668901
89negative regulation of mRNA processing (GO:0050686)3.05645600
90mitotic G1 DNA damage checkpoint (GO:0031571)3.04650028
91gene silencing (GO:0016458)3.04567377
92mitotic spindle assembly checkpoint (GO:0007094)3.04427975
93attachment of spindle microtubules to kinetochore (GO:0008608)3.04002105
94telomere maintenance via recombination (GO:0000722)3.03834685
95regulation of nucleobase-containing compound transport (GO:0032239)3.02927598
96telomere maintenance via semi-conservative replication (GO:0032201)3.02709337
97synaptonemal complex organization (GO:0070193)3.02399281
98ATP-dependent chromatin remodeling (GO:0043044)3.01893405
99DNA replication-independent nucleosome assembly (GO:0006336)3.01317504
100DNA replication-independent nucleosome organization (GO:0034724)3.01317504
101binding of sperm to zona pellucida (GO:0007339)3.01255502
102ribonucleoprotein complex biogenesis (GO:0022613)3.00884842
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00696943
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00696943
105positive regulation of mitotic sister chromatid separation (GO:1901970)3.00696943
106negative regulation of mRNA metabolic process (GO:1903312)2.99350928
107mitotic G2/M transition checkpoint (GO:0044818)2.98613094
108folic acid-containing compound biosynthetic process (GO:0009396)2.98487981
109negative regulation of gene expression, epigenetic (GO:0045814)2.98161417
110nucleobase biosynthetic process (GO:0046112)2.97693761
111regulation of centrosome cycle (GO:0046605)2.97676874
112spindle assembly checkpoint (GO:0071173)2.97447252
1133-UTR-mediated mRNA stabilization (GO:0070935)2.96876338
114chromatin silencing (GO:0006342)2.96668686
115chromatin remodeling at centromere (GO:0031055)2.95419573
116ribosome assembly (GO:0042255)2.93522170
117chaperone-mediated protein complex assembly (GO:0051131)2.93355208
118non-recombinational repair (GO:0000726)2.88326680
119double-strand break repair via nonhomologous end joining (GO:0006303)2.88326680
120mRNA transport (GO:0051028)2.88144655
121sperm-egg recognition (GO:0035036)2.87683651
122protein complex localization (GO:0031503)2.87233275
123chromosome segregation (GO:0007059)2.85580849
124dosage compensation (GO:0007549)2.85467160
125kinetochore organization (GO:0051383)2.85332874
126nucleosome disassembly (GO:0006337)2.84507430
127protein-DNA complex disassembly (GO:0032986)2.84507430
128termination of RNA polymerase II transcription (GO:0006369)2.83809057
129regulation of mitotic spindle organization (GO:0060236)2.81284515
130mitotic recombination (GO:0006312)2.79649382
131postreplication repair (GO:0006301)2.78261785
132establishment of chromosome localization (GO:0051303)2.76905906
133G1 DNA damage checkpoint (GO:0044783)2.76764305
134IMP biosynthetic process (GO:0006188)2.75278214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.72557022
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.37794699
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.95854256
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66070210
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.39992137
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26743515
7MYC_22102868_ChIP-Seq_BL_Human3.04598360
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97656664
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.83677142
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79849971
11AR_21909140_ChIP-Seq_LNCAP_Human2.31017347
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22845581
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.10729421
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05676668
15XRN2_22483619_ChIP-Seq_HELA_Human2.04048223
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03899710
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03106810
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93501126
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87152047
20VDR_21846776_ChIP-Seq_THP-1_Human1.82732583
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80549676
22ZNF263_19887448_ChIP-Seq_K562_Human1.79082323
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77923093
24* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.76664956
25CIITA_25753668_ChIP-Seq_RAJI_Human1.75631923
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70538578
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68838872
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68838872
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68838872
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.60960304
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60864379
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60842584
33TCF7_22412390_ChIP-Seq_EML_Mouse1.59741675
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58023313
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56953401
36KDM5A_27292631_Chip-Seq_BREAST_Human1.55847146
37ELK1_19687146_ChIP-ChIP_HELA_Human1.53453209
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52360568
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51119625
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50482740
41* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50356658
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50188329
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47995263
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44295720
45VDR_23849224_ChIP-Seq_CD4+_Human1.42642057
46GABP_19822575_ChIP-Seq_HepG2_Human1.39890083
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37697837
48CLOCK_20551151_ChIP-Seq_293T_Human1.36519887
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36234830
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35828755
51TTF2_22483619_ChIP-Seq_HELA_Human1.35796095
52SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.35474282
53KDM2B_26808549_Chip-Seq_DND41_Human1.34236956
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33401353
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32913203
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32349183
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30467556
58FOXP3_21729870_ChIP-Seq_TREG_Human1.29665703
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29416716
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29307394
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.28597196
62DCP1A_22483619_ChIP-Seq_HELA_Human1.27076867
63UTX_26944678_Chip-Seq_JUKART_Human1.26053998
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24960154
65* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24834734
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20227955
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19418500
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19013881
69MAF_26560356_Chip-Seq_TH1_Human1.17970537
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16970314
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16357125
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15439040
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.12268291
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12011472
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12008832
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10739156
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10717309
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.10251155
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09808608
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.09671588
81* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06730119
82TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04782129
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04716935
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04111433
85CHD1_26751641_Chip-Seq_LNCaP_Human1.03429237
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02994463
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02991919
88* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02506968
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.02186476
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.01899802
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01385663
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99788629
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99535799
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99535305
95* MYB_26560356_Chip-Seq_TH1_Human0.99220728
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96679898
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.96425818
98* NCOR1_26117541_ChIP-Seq_K562_Human0.94981519
99TFEB_21752829_ChIP-Seq_HELA_Human0.94732665
100* MYB_26560356_Chip-Seq_TH2_Human0.94214808
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93340028
102* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92366926
103MAF_26560356_Chip-Seq_TH2_Human0.92003846
104THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91699457
105PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91682900
106* ATF3_27146783_Chip-Seq_COLON_Human0.91048083
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90457929
108GABP_17652178_ChIP-ChIP_JURKAT_Human0.89658389
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89617972
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88552402
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.88547936
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88501063
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.88172212
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87316852
115MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86735697
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84091806
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83054409
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82483408
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82429954
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81798373
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80708672
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80600621
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80488229
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80409222
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80248236
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79486104
127RUNX1_22412390_ChIP-Seq_EML_Mouse0.79383735
128VDR_24763502_ChIP-Seq_THP-1_Human0.78422824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.05967966
2MP0003693_abnormal_embryo_hatching4.04423512
3MP0010094_abnormal_chromosome_stability3.82393860
4MP0004957_abnormal_blastocyst_morpholog3.75487893
5MP0003077_abnormal_cell_cycle3.36447509
6MP0008057_abnormal_DNA_replication2.98863734
7MP0005410_abnormal_fertilization2.98861629
8MP0001730_embryonic_growth_arrest2.64537424
9MP0010352_gastrointestinal_tract_polyps2.64350980
10MP0002009_preneoplasia2.56413305
11MP0003123_paternal_imprinting2.52496975
12MP0010307_abnormal_tumor_latency2.48918985
13MP0008877_abnormal_DNA_methylation2.48864996
14MP0003941_abnormal_skin_development2.48082506
15MP0003705_abnormal_hypodermis_morpholog2.36353356
16MP0008007_abnormal_cellular_replicative2.33072824
17MP0000350_abnormal_cell_proliferation2.20796321
18MP0005076_abnormal_cell_differentiation2.18423522
19MP0010234_abnormal_vibrissa_follicle2.10224530
20MP0004808_abnormal_hematopoietic_stem1.98427079
21MP0002396_abnormal_hematopoietic_system1.96611376
22MP0001697_abnormal_embryo_size1.95265759
23MP0008058_abnormal_DNA_repair1.93511395
24* MP0001929_abnormal_gametogenesis1.91597381
25MP0000537_abnormal_urethra_morphology1.91222602
26* MP0005380_embryogenesis_phenotype1.87556997
27* MP0001672_abnormal_embryogenesis/_devel1.87556997
28MP0002084_abnormal_developmental_patter1.83981095
29MP0009379_abnormal_foot_pigmentation1.83898285
30MP0004197_abnormal_fetal_growth/weight/1.78666032
31MP0003984_embryonic_growth_retardation1.78303125
32MP0009697_abnormal_copulation1.78238172
33MP0002086_abnormal_extraembryonic_tissu1.76957312
34MP0002088_abnormal_embryonic_growth/wei1.76345691
35MP0002080_prenatal_lethality1.75505485
36MP0008932_abnormal_embryonic_tissue1.75173126
37MP0002085_abnormal_embryonic_tissue1.70865905
38MP0009278_abnormal_bone_marrow1.70583765
39MP0006054_spinal_hemorrhage1.65449800
40MP0003718_maternal_effect1.63874770
41* MP0002210_abnormal_sex_determination1.62745067
42MP0003567_abnormal_fetal_cardiomyocyte1.61243632
43MP0000490_abnormal_crypts_of1.58230382
44* MP0003698_abnormal_male_reproductive1.58161516
45MP0002796_impaired_skin_barrier1.54092681
46* MP0001145_abnormal_male_reproductive1.53198298
47MP0001545_abnormal_hematopoietic_system1.52702892
48MP0005397_hematopoietic_system_phenotyp1.52702892
49MP0002653_abnormal_ependyma_morphology1.43659869
50MP0000313_abnormal_cell_death1.33570887
51MP0003937_abnormal_limbs/digits/tail_de1.33526695
52MP0002019_abnormal_tumor_incidence1.31676397
53MP0000703_abnormal_thymus_morphology1.29727515
54MP0001293_anophthalmia1.28188361
55MP0003786_premature_aging1.27920963
56MP0000733_abnormal_muscle_development1.27008320
57MP0001286_abnormal_eye_development1.23922610
58* MP0000653_abnormal_sex_gland1.22790424
59MP0003121_genomic_imprinting1.20543895
60MP0004233_abnormal_muscle_weight1.17117533
61MP0009672_abnormal_birth_weight1.16891196
62MP0005501_abnormal_skin_physiology1.16276848
63MP0003303_peritoneal_inflammation1.15334899
64MP0003300_gastrointestinal_ulcer1.10805663
65MP0002398_abnormal_bone_marrow1.08991749
66MP0003763_abnormal_thymus_physiology1.08847067
67MP0005623_abnormal_meninges_morphology1.07677391
68MP0001849_ear_inflammation1.07278564
69MP0001346_abnormal_lacrimal_gland1.05663108
70MP0003115_abnormal_respiratory_system1.04804606
71* MP0002161_abnormal_fertility/fecundity1.04345730
72MP0000428_abnormal_craniofacial_morphol1.03194953
73MP0001188_hyperpigmentation1.00310630
74MP0006292_abnormal_olfactory_placode0.99217239
75MP0002092_abnormal_eye_morphology0.98566522
76MP0002111_abnormal_tail_morphology0.98493484
77MP0009333_abnormal_splenocyte_physiolog0.98407045
78MP0005666_abnormal_adipose_tissue0.97361176
79MP0008770_decreased_survivor_rate0.97001941
80MP0009703_decreased_birth_body0.96254948
81MP0003119_abnormal_digestive_system0.95863498
82MP0002722_abnormal_immune_system0.94088725
83MP0004185_abnormal_adipocyte_glucose0.92370942
84MP0001661_extended_life_span0.90872891
85MP0005451_abnormal_body_composition0.90157995
86MP0002254_reproductive_system_inflammat0.89320677
87MP0003385_abnormal_body_wall0.87428558
88MP0010030_abnormal_orbit_morphology0.86690319
89MP0001915_intracranial_hemorrhage0.85864995
90MP0003890_abnormal_embryonic-extraembry0.85050941
91MP0002925_abnormal_cardiovascular_devel0.85045625
92MP0000762_abnormal_tongue_morphology0.83892957
93MP0000689_abnormal_spleen_morphology0.82410062
94MP0000432_abnormal_head_morphology0.82226742
95MP0002166_altered_tumor_susceptibility0.80950117
96MP0003566_abnormal_cell_adhesion0.80626367
97MP0003943_abnormal_hepatobiliary_system0.79074811
98MP0002233_abnormal_nose_morphology0.78882497
99MP0000358_abnormal_cell_content/0.78736418
100MP0005187_abnormal_penis_morphology0.78621389
101MP0009053_abnormal_anal_canal0.78420937
102MP0005621_abnormal_cell_physiology0.77602520
103MP0000477_abnormal_intestine_morphology0.77527433
104MP0003221_abnormal_cardiomyocyte_apopto0.77285832
105MP0002877_abnormal_melanocyte_morpholog0.76559538
106MP0003315_abnormal_perineum_morphology0.76537440
107MP0002160_abnormal_reproductive_system0.76207112
108MP0005384_cellular_phenotype0.74228531
109MP0010630_abnormal_cardiac_muscle0.73789453
110MP0004084_abnormal_cardiac_muscle0.73065109
111MP0002429_abnormal_blood_cell0.72083700
112MP0000566_synostosis0.71860002
113MP0001727_abnormal_embryo_implantation0.71825116
114MP0003935_abnormal_craniofacial_develop0.69118794
115MP0003861_abnormal_nervous_system0.68266279
116MP0001666_abnormal_nutrient_absorption0.67853226
117MP0000266_abnormal_heart_morphology0.66919685
118MP0001784_abnormal_fluid_regulation0.66672007
119MP0006035_abnormal_mitochondrial_morpho0.64591326
120MP0005023_abnormal_wound_healing0.62578884
121MP0001340_abnormal_eyelid_morphology0.61292508
122MP0002697_abnormal_eye_size0.61289146
123MP0000716_abnormal_immune_system0.60064080
124MP0002089_abnormal_postnatal_growth/wei0.59885653
125MP0003755_abnormal_palate_morphology0.59474866
126MP0000377_abnormal_hair_follicle0.58062181
127MP0004264_abnormal_extraembryonic_tissu0.57686765
128MP0002006_tumorigenesis0.57593876
129MP0001881_abnormal_mammary_gland0.57407579
130MP0003942_abnormal_urinary_system0.56589077
131MP0000858_altered_metastatic_potential0.56304082
132MP0004087_abnormal_muscle_fiber0.56118376
133MP0002114_abnormal_axial_skeleton0.55871525

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00049452
2Chromsome breakage (HP:0040012)3.81658436
3Nephroblastoma (Wilms tumor) (HP:0002667)3.54487349
4Ependymoma (HP:0002888)3.39257662
5Embryonal renal neoplasm (HP:0011794)3.36667443
6Progressive external ophthalmoplegia (HP:0000590)3.30596112
7Abnormality of cells of the erythroid lineage (HP:0012130)3.25501969
8Colon cancer (HP:0003003)3.20722943
9Cortical dysplasia (HP:0002539)3.07516328
10Basal cell carcinoma (HP:0002671)3.03728083
11Abnormal number of erythroid precursors (HP:0012131)3.02053141
12Selective tooth agenesis (HP:0001592)2.92670746
13Increased nuchal translucency (HP:0010880)2.80690020
14Short 4th metacarpal (HP:0010044)2.74705335
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74705335
16Reticulocytopenia (HP:0001896)2.74599402
17Abnormality of the lower motor neuron (HP:0002366)2.69823460
18Impulsivity (HP:0100710)2.69401634
19Hyperacusis (HP:0010780)2.68308604
20Nasal polyposis (HP:0100582)2.58773928
21Prominent nose (HP:0000448)2.57920963
22Proximal placement of thumb (HP:0009623)2.57852910
23Medulloblastoma (HP:0002885)2.57727839
24Abnormal lung lobation (HP:0002101)2.57073808
25Birth length less than 3rd percentile (HP:0003561)2.52898035
26Ankyloglossia (HP:0010296)2.51767944
27High pitched voice (HP:0001620)2.51140112
28Biliary tract neoplasm (HP:0100574)2.47661171
29Macrocytic anemia (HP:0001972)2.47517822
30Abnormality of the astrocytes (HP:0100707)2.44078711
31Astrocytoma (HP:0009592)2.44078711
32Deviation of the thumb (HP:0009603)2.41829778
33Volvulus (HP:0002580)2.41695683
34Progressive muscle weakness (HP:0003323)2.38514516
35Rhabdomyosarcoma (HP:0002859)2.34948470
36Heterotopia (HP:0002282)2.32367785
37Acute myeloid leukemia (HP:0004808)2.29921477
38Male infertility (HP:0003251)2.29909687
39Rectal prolapse (HP:0002035)2.28951684
40Microvesicular hepatic steatosis (HP:0001414)2.25096075
41Embryonal neoplasm (HP:0002898)2.23334712
42Abnormality of the preputium (HP:0100587)2.23307060
43Abnormality of the anterior horn cell (HP:0006802)2.22899792
44Degeneration of anterior horn cells (HP:0002398)2.22899792
45Termporal pattern (HP:0011008)2.22066965
46Insidious onset (HP:0003587)2.22066965
47Atresia of the external auditory canal (HP:0000413)2.21906913
48Abnormality of the nasal mucosa (HP:0000433)2.21605391
49Deep philtrum (HP:0002002)2.20333790
50Hepatoblastoma (HP:0002884)2.19927713
51Abnormality of the fingertips (HP:0001211)2.19592041
52Neoplasm of the colon (HP:0100273)2.18323127
53Breast hypoplasia (HP:0003187)2.18320000
54Asymmetry of the thorax (HP:0001555)2.18243398
55Uterine neoplasm (HP:0010784)2.17639472
56Neoplasm of striated muscle (HP:0009728)2.17114396
57Neoplasm of the pancreas (HP:0002894)2.15919542
58Pelvic girdle muscle weakness (HP:0003749)2.15847525
59Uterine leiomyosarcoma (HP:0002891)2.12809672
60Leiomyosarcoma (HP:0100243)2.12809672
61Gastrointestinal carcinoma (HP:0002672)2.10880924
62Malignant gastrointestinal tract tumors (HP:0006749)2.10880924
63Neoplasm of the oral cavity (HP:0100649)2.10181309
64Abnormality of the ileum (HP:0001549)2.09944047
65Abnormality of the 4th metacarpal (HP:0010012)2.09877317
66Overlapping toe (HP:0001845)2.09042773
67Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08362241
68Annular pancreas (HP:0001734)2.08290548
69Abnormality of the left ventricular outflow tract (HP:0011103)2.07572469
70Subaortic stenosis (HP:0001682)2.07572469
71Patellar aplasia (HP:0006443)2.07303693
72Bicuspid aortic valve (HP:0001647)2.06095191
73Cafe-au-lait spot (HP:0000957)2.05712937
74Amyotrophic lateral sclerosis (HP:0007354)2.05287301
75High anterior hairline (HP:0009890)2.03795191
76Angiofibromas (HP:0010615)2.03497921
77Adenoma sebaceum (HP:0009720)2.03497921
78Facial hemangioma (HP:0000329)2.02807799
79Hypoglycemic seizures (HP:0002173)2.01746227
80Multiple enchondromatosis (HP:0005701)2.00373239
81Genu recurvatum (HP:0002816)1.99899425
82Aplasia/Hypoplasia of the patella (HP:0006498)1.99652512
83Duplication of thumb phalanx (HP:0009942)1.99424151
84Absent thumb (HP:0009777)1.99092999
85Posterior subcapsular cataract (HP:0007787)1.98426530
86Pancreatic islet-cell hyperplasia (HP:0004510)1.96682044
87Neoplasm of the small intestine (HP:0100833)1.95648812
88Renal duplication (HP:0000075)1.95593918
89Myelodysplasia (HP:0002863)1.94959314
90Glioma (HP:0009733)1.94859226
91Ankle contracture (HP:0006466)1.94275579
92Pointed chin (HP:0000307)1.92415982
93Cutaneous melanoma (HP:0012056)1.91965098
94Agnosia (HP:0010524)1.91541877
95Sandal gap (HP:0001852)1.90672843
96Spastic diplegia (HP:0001264)1.90264677
97Increased density of long bones (HP:0006392)1.90143896
98Abnormality of chromosome stability (HP:0003220)1.90028390
99Capillary hemangiomas (HP:0005306)1.89824346
100Abnormality of oral frenula (HP:0000190)1.89780711
101Recurrent bronchitis (HP:0002837)1.89221605
102Poikiloderma (HP:0001029)1.88447454
103Entropion (HP:0000621)1.88269534
104Renovascular hypertension (HP:0100817)1.88097873
105Squamous cell carcinoma (HP:0002860)1.87930255
106Aplasia/Hypoplasia of the uvula (HP:0010293)1.87619776
107Truncal obesity (HP:0001956)1.87293605
108Abnormal cartilage morphology (HP:0002763)1.86971634
109Transitional cell carcinoma of the bladder (HP:0006740)1.86940290
110Broad palm (HP:0001169)1.85983113
111Overriding aorta (HP:0002623)1.85395081
112Missing ribs (HP:0000921)1.85301278
113Short middle phalanx of the 5th finger (HP:0004220)1.83940405
114Enlarged penis (HP:0000040)1.83934465
115Subacute progressive viral hepatitis (HP:0006572)1.83810516
116Absent radius (HP:0003974)1.83646594
117Choanal stenosis (HP:0000452)1.82453604
118Oligodactyly (HP:0012165)1.81461518
119Deep palmar crease (HP:0006191)1.81045853
120Dysmetric saccades (HP:0000641)1.81010980
121Skin tags (HP:0010609)1.81000024
122Facial cleft (HP:0002006)1.80910189
123Papillary thyroid carcinoma (HP:0002895)1.79814722
124Choanal atresia (HP:0000453)1.79216300
125Spinal cord lesions (HP:0100561)1.79098796
126Syringomyelia (HP:0003396)1.79098796
127Bronchitis (HP:0012387)1.77717432
128Long eyelashes (HP:0000527)1.77264462
129Abnormality of the salivary glands (HP:0010286)1.77229190
130Premature ovarian failure (HP:0008209)1.77087492
131Horseshoe kidney (HP:0000085)1.76831966
132Infertility (HP:0000789)1.75958308
133Cutis marmorata (HP:0000965)1.75888149
134Gout (HP:0001997)1.75269597
135Elfin facies (HP:0004428)1.75228181
136Diastasis recti (HP:0001540)1.75153314
137Megaloblastic anemia (HP:0001889)1.74537751
138Fibrous tissue neoplasm (HP:0012316)1.74451184
139Acanthocytosis (HP:0001927)1.74323349
140Carpal bone hypoplasia (HP:0001498)1.73118033
141Gonadotropin excess (HP:0000837)1.73103056
142Cerebral aneurysm (HP:0004944)1.72716530
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.72633051
144Neoplasm of the rectum (HP:0100743)1.72441240
145Meckel diverticulum (HP:0002245)1.72437407
146Thrombocytosis (HP:0001894)1.72305888
147Small intestinal stenosis (HP:0012848)1.72201114
148Duodenal stenosis (HP:0100867)1.72201114
149Pallor (HP:0000980)1.72124968
150Ovarian neoplasm (HP:0100615)1.71443931
151Abnormality of the duodenum (HP:0002246)1.71186934
152Shoulder girdle muscle weakness (HP:0003547)1.71068859
153Insomnia (HP:0100785)1.70952774
154Abnormality of glycolysis (HP:0004366)1.70821956
155Achilles tendon contracture (HP:0001771)1.70009980
156Fibroma (HP:0010614)1.69951146
157Abnormality of the calcaneus (HP:0008364)1.68074133
158Rectovaginal fistula (HP:0000143)1.66523905
159Rectal fistula (HP:0100590)1.66523905
160Abnormal foot bone ossification (HP:0010675)1.65893186
161Hyperinsulinemic hypoglycemia (HP:0000825)1.64107088
162Skull defect (HP:0001362)1.63390969
163Bladder neoplasm (HP:0009725)1.62860460
164Bladder carcinoma (HP:0002862)1.62860460
165Right ventricular cardiomyopathy (HP:0011663)1.62641359
166Increased serum pyruvate (HP:0003542)1.60604522
167Absent forearm bone (HP:0003953)1.60538857
168Aplasia involving forearm bones (HP:0009822)1.60538857
169Neuroblastoma (HP:0003006)1.59331134
170Primitive neuroectodermal tumor (HP:0030065)1.59331134
171Neuroblastic tumors (HP:0004376)1.59331134
172Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59331134
173Aplasia/Hypoplasia of the sternum (HP:0006714)1.59011991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.81126235
2EEF2K3.41850598
3PKN23.15578752
4WEE13.15286260
5TRIB33.04507682
6MAP3K102.89853849
7* NEK22.77068991
8PBK2.51982348
9BUB12.34532284
10CDK122.21463700
11PDK32.16218315
12PDK42.16218315
13TAF12.10462689
14SMG12.08570925
15PLK42.07806446
16SCYL22.07066767
17NEK11.94683784
18TTK1.91058797
19LATS21.89320815
20DYRK31.85688295
21TESK11.82142758
22CDK41.80531621
23ICK1.78060089
24RPS6KA41.54558823
25RPS6KB21.50426298
26ACVR1B1.46620977
27PRKD31.46466972
28MAP3K81.39491649
29MAP4K11.38418687
30PAK41.37702744
31SRPK11.37549439
32ALK1.37510259
33CDK61.34375726
34STK101.32511825
35PASK1.32107177
36PLK11.31931919
37ATR1.29493868
38LRRK21.25850495
39VRK21.23017326
40BRSK21.22724184
41AURKB1.20517647
42TYRO31.19442255
43CHEK11.19050064
44TLK11.16424728
45CDK71.15143302
46NME21.14096749
47STK241.13101945
48TESK21.12391757
49CHEK21.11791569
50PDK21.10775608
51BRAF1.04296080
52FGFR41.04075556
53PTK61.03733301
54EIF2AK11.03723928
55CDK191.03430598
56MST41.00906583
57RIPK11.00760191
58STK30.99400757
59PNCK0.97213505
60BRD40.95461926
61TGFBR10.93123956
62MAP2K30.93041847
63GRK60.92961257
64MAP3K90.91158721
65MTOR0.90414710
66EIF2AK20.90138736
67PRPF4B0.87364665
68MKNK10.87303964
69TSSK60.87107502
70FLT30.86630143
71CDK20.83974494
72PIM10.81485329
73STK38L0.81370030
74ERBB40.81156239
75STK40.80740044
76ATM0.79871609
77BRSK10.79428030
78MKNK20.78800969
79TTN0.77620405
80KSR20.73908707
81YES10.71483412
82PDGFRA0.70493077
83MELK0.70008712
84CAMK1D0.68858003
85PLK30.68292687
86STK380.67735132
87ZAK0.66443659
88CAMK1G0.65315648
89DYRK1B0.64951032
90MARK30.58122831
91NLK0.57191461
92CDK90.56470214
93AURKA0.56147990
94MET0.55653008
95DMPK0.55419085
96CDK10.54989533
97CLK10.54166815
98LATS10.53944958
99PAK20.52518253
100TAOK10.50936659
101STK160.50278114
102BMX0.49925854
103PAK10.49044516
104VRK10.48824087
105MST1R0.48359009
106PDK10.47618171
107ZAP700.46840137
108AKT20.46221053
109MAP3K130.46089479
110MAPKAPK30.45613812
111FGFR10.45554969
112ILK0.44995689
113CAMKK10.43897495
114TNIK0.41513551
115CSNK1E0.40850392
116RAF10.40370414
117KSR10.40198989
118CSNK2A20.38988249
119PRKDC0.38591497
120KDR0.38506031
121NEK90.37610446
122CSNK1D0.36988266
123CCNB10.36179598
124MAPK110.33898000
125CSF1R0.33286135
126EIF2AK30.33208257
127PTK2B0.33101761
128CDK30.32550668
129RPS6KB10.32488013
130CSNK2A10.32234174
131CDK11A0.29610548
132FGFR30.29253519
133STK110.27672160
134RPS6KA10.27569568

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06107255
2RNA transport_Homo sapiens_hsa030133.18294285
3Mismatch repair_Homo sapiens_hsa034303.17121193
4Spliceosome_Homo sapiens_hsa030402.93236744
5Cell cycle_Homo sapiens_hsa041102.71400338
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61385523
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45000076
8* mRNA surveillance pathway_Homo sapiens_hsa030152.26407540
9Base excision repair_Homo sapiens_hsa034102.26191207
10Ribosome_Homo sapiens_hsa030102.08206561
11Nucleotide excision repair_Homo sapiens_hsa034201.98187995
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93969663
13Homologous recombination_Homo sapiens_hsa034401.70185783
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.68794096
15* Oocyte meiosis_Homo sapiens_hsa041141.66184104
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59439684
17One carbon pool by folate_Homo sapiens_hsa006701.59026715
18Fanconi anemia pathway_Homo sapiens_hsa034601.57666244
19Systemic lupus erythematosus_Homo sapiens_hsa053221.54805639
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53154969
21RNA degradation_Homo sapiens_hsa030181.47284072
22Pyruvate metabolism_Homo sapiens_hsa006201.40324927
23p53 signaling pathway_Homo sapiens_hsa041151.38594248
24mTOR signaling pathway_Homo sapiens_hsa041501.38164779
25Viral carcinogenesis_Homo sapiens_hsa052031.37567491
26Basal transcription factors_Homo sapiens_hsa030221.35506701
27RNA polymerase_Homo sapiens_hsa030201.30831103
28Chronic myeloid leukemia_Homo sapiens_hsa052201.27266743
29Antigen processing and presentation_Homo sapiens_hsa046121.25849438
30Pyrimidine metabolism_Homo sapiens_hsa002401.25535021
31Small cell lung cancer_Homo sapiens_hsa052221.18354616
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.17400417
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16422789
34Non-homologous end-joining_Homo sapiens_hsa034501.15531029
35HTLV-I infection_Homo sapiens_hsa051661.15430802
36Non-small cell lung cancer_Homo sapiens_hsa052231.09610725
37MicroRNAs in cancer_Homo sapiens_hsa052061.07384414
38Thyroid cancer_Homo sapiens_hsa052161.07135149
39Colorectal cancer_Homo sapiens_hsa052101.04338696
40Epstein-Barr virus infection_Homo sapiens_hsa051691.02593765
41VEGF signaling pathway_Homo sapiens_hsa043701.02097450
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01205794
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97029004
44B cell receptor signaling pathway_Homo sapiens_hsa046620.95153294
45* Alcoholism_Homo sapiens_hsa050340.94360223
46Pentose phosphate pathway_Homo sapiens_hsa000300.93134346
47* Herpes simplex infection_Homo sapiens_hsa051680.91481075
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91193235
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90694629
50Vitamin B6 metabolism_Homo sapiens_hsa007500.88753318
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87555021
52Vitamin digestion and absorption_Homo sapiens_hsa049770.86676920
53Arginine biosynthesis_Homo sapiens_hsa002200.84823829
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84202839
55Biosynthesis of amino acids_Homo sapiens_hsa012300.81995774
56Acute myeloid leukemia_Homo sapiens_hsa052210.80858456
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80757119
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78045254
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77477017
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76128570
61Endometrial cancer_Homo sapiens_hsa052130.75680727
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75389805
63HIF-1 signaling pathway_Homo sapiens_hsa040660.73988931
64Glioma_Homo sapiens_hsa052140.72797750
65Bladder cancer_Homo sapiens_hsa052190.72400415
66Folate biosynthesis_Homo sapiens_hsa007900.71182300
67Renin-angiotensin system_Homo sapiens_hsa046140.70345648
68Steroid biosynthesis_Homo sapiens_hsa001000.70162567
69* Hippo signaling pathway_Homo sapiens_hsa043900.69780827
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69746190
71Purine metabolism_Homo sapiens_hsa002300.69687167
72Hepatitis B_Homo sapiens_hsa051610.67940234
73Primary immunodeficiency_Homo sapiens_hsa053400.67889105
74Pancreatic cancer_Homo sapiens_hsa052120.67617403
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.66853431
76T cell receptor signaling pathway_Homo sapiens_hsa046600.66760157
77Notch signaling pathway_Homo sapiens_hsa043300.66576735
78Propanoate metabolism_Homo sapiens_hsa006400.66495582
79Selenocompound metabolism_Homo sapiens_hsa004500.65767489
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65594116
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64121228
82Adherens junction_Homo sapiens_hsa045200.63533820
83Prostate cancer_Homo sapiens_hsa052150.63403988
84Renal cell carcinoma_Homo sapiens_hsa052110.61616967
85AMPK signaling pathway_Homo sapiens_hsa041520.61069060
86Basal cell carcinoma_Homo sapiens_hsa052170.60789711
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59688100
88TGF-beta signaling pathway_Homo sapiens_hsa043500.59659277
89* Proteoglycans in cancer_Homo sapiens_hsa052050.59054869
90Estrogen signaling pathway_Homo sapiens_hsa049150.58885812
91Shigellosis_Homo sapiens_hsa051310.58761538
92Dorso-ventral axis formation_Homo sapiens_hsa043200.57317531
93Arginine and proline metabolism_Homo sapiens_hsa003300.57159955
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.56283874
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.55934217
96Hedgehog signaling pathway_Homo sapiens_hsa043400.54766428
97Glucagon signaling pathway_Homo sapiens_hsa049220.54355493
98Pathways in cancer_Homo sapiens_hsa052000.53301748
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.51711956
100Fat digestion and absorption_Homo sapiens_hsa049750.51261917
101Apoptosis_Homo sapiens_hsa042100.48744580
102Inositol phosphate metabolism_Homo sapiens_hsa005620.48424039
103* Insulin signaling pathway_Homo sapiens_hsa049100.48335729
104Galactose metabolism_Homo sapiens_hsa000520.47968702
105FoxO signaling pathway_Homo sapiens_hsa040680.47928556
106Fatty acid metabolism_Homo sapiens_hsa012120.47869062
107Tight junction_Homo sapiens_hsa045300.47313199
108Endocytosis_Homo sapiens_hsa041440.47258873
109Proteasome_Homo sapiens_hsa030500.46661556
110Wnt signaling pathway_Homo sapiens_hsa043100.46023585
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45981023
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45119291
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44953912
114Lysine degradation_Homo sapiens_hsa003100.44184803
115Fatty acid biosynthesis_Homo sapiens_hsa000610.43404523
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42955497
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41504662
118Carbon metabolism_Homo sapiens_hsa012000.41451974
119Toxoplasmosis_Homo sapiens_hsa051450.40740762
120Viral myocarditis_Homo sapiens_hsa054160.40253150
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39833929
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38654807
123Measles_Homo sapiens_hsa051620.38063645
124ErbB signaling pathway_Homo sapiens_hsa040120.37566198
125N-Glycan biosynthesis_Homo sapiens_hsa005100.37137880
126Fructose and mannose metabolism_Homo sapiens_hsa000510.34934378
127Starch and sucrose metabolism_Homo sapiens_hsa005000.28125117
128Melanoma_Homo sapiens_hsa052180.27158708

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »