PPM1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.85997892
2DNA deamination (GO:0045006)5.73603489
3viral transcription (GO:0019083)5.55355978
4translational termination (GO:0006415)5.40058232
5nuclear pore complex assembly (GO:0051292)5.33989699
6telomere maintenance via semi-conservative replication (GO:0032201)5.16505489
7mitotic chromosome condensation (GO:0007076)5.13307784
8DNA strand elongation involved in DNA replication (GO:0006271)4.96232563
9DNA replication initiation (GO:0006270)4.88751565
10maturation of SSU-rRNA (GO:0030490)4.83309202
11ribosomal small subunit biogenesis (GO:0042274)4.82821047
12translational elongation (GO:0006414)4.74819799
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.73223719
14DNA strand elongation (GO:0022616)4.73120861
15regulation of translational fidelity (GO:0006450)4.64540339
16cotranslational protein targeting to membrane (GO:0006613)4.60456025
17protein targeting to ER (GO:0045047)4.59368154
18nuclear pore organization (GO:0006999)4.52720558
19telomere maintenance via recombination (GO:0000722)4.38749904
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36404814
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.35419895
22protein localization to endoplasmic reticulum (GO:0070972)4.33484936
23translational initiation (GO:0006413)4.30672937
24mitotic sister chromatid segregation (GO:0000070)4.22596738
25viral life cycle (GO:0019058)4.15460050
26cellular protein complex disassembly (GO:0043624)4.09572207
27chromosome condensation (GO:0030261)4.00431968
28peptidyl-arginine omega-N-methylation (GO:0035247)3.99124560
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.98380345
30pore complex assembly (GO:0046931)3.95723504
31mitotic recombination (GO:0006312)3.94283745
32sister chromatid segregation (GO:0000819)3.90434113
33ribosomal large subunit biogenesis (GO:0042273)3.86694504
34heterochromatin organization (GO:0070828)3.85870198
35telomere maintenance via telomere lengthening (GO:0010833)3.80382065
36mitotic metaphase plate congression (GO:0007080)3.79281059
37protein complex disassembly (GO:0043241)3.76207428
38proline biosynthetic process (GO:0006561)3.75375314
39DNA unwinding involved in DNA replication (GO:0006268)3.74602646
40establishment of viral latency (GO:0019043)3.73449802
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68442258
42DNA topological change (GO:0006265)3.67151146
43ribonucleoprotein complex biogenesis (GO:0022613)3.66962522
44Golgi transport vesicle coating (GO:0048200)3.64416755
45COPI coating of Golgi vesicle (GO:0048205)3.64416755
46protein complex localization (GO:0031503)3.57651219
47mitotic sister chromatid cohesion (GO:0007064)3.53425023
48macromolecular complex disassembly (GO:0032984)3.52944810
49DNA packaging (GO:0006323)3.52074218
50DNA duplex unwinding (GO:0032508)3.51142101
51pseudouridine synthesis (GO:0001522)3.49590146
52histone arginine methylation (GO:0034969)3.46605470
53protein-DNA complex disassembly (GO:0032986)3.44755549
54nucleosome disassembly (GO:0006337)3.44755549
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.43038293
56peptidyl-arginine methylation (GO:0018216)3.41079851
57peptidyl-arginine N-methylation (GO:0035246)3.41079851
58nuclear envelope disassembly (GO:0051081)3.40239077
59membrane disassembly (GO:0030397)3.40239077
60DNA conformation change (GO:0071103)3.38875921
61formation of translation preinitiation complex (GO:0001731)3.38005379
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.34909643
63DNA geometric change (GO:0032392)3.34002648
64rRNA processing (GO:0006364)3.32130542
65nucleobase-containing small molecule interconversion (GO:0015949)3.31285837
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30653664
67mRNA catabolic process (GO:0006402)3.27771018
68DNA replication checkpoint (GO:0000076)3.24760875
69RNA catabolic process (GO:0006401)3.23436083
70translation (GO:0006412)3.22295214
71rRNA metabolic process (GO:0016072)3.21739784
72regulation of translational termination (GO:0006449)3.21315799
73ribosome biogenesis (GO:0042254)3.20790186
74negative regulation of mRNA metabolic process (GO:1903312)3.19386433
75ribosome assembly (GO:0042255)3.15932534
76regulation of RNA export from nucleus (GO:0046831)3.15140074
77regulation of mammary gland epithelial cell proliferation (GO:0033599)3.08972475
78antigen processing and presentation via MHC class Ib (GO:0002475)3.07589861
79negative regulation of RNA splicing (GO:0033119)3.06709022
80positive regulation of chromosome segregation (GO:0051984)3.06233061
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04743561
82metaphase plate congression (GO:0051310)3.04597188
83CENP-A containing nucleosome assembly (GO:0034080)3.03462752
84protein maturation by protein folding (GO:0022417)3.01969458
85regulation of mitotic spindle organization (GO:0060236)3.01346243
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00993140
87chromatin remodeling at centromere (GO:0031055)2.99722487
88cellular protein complex localization (GO:0034629)2.99556525
89tRNA methylation (GO:0030488)2.98620386
90proteasome assembly (GO:0043248)2.94913087
91spliceosomal snRNP assembly (GO:0000387)2.94444601
92nucleobase biosynthetic process (GO:0046112)2.93924681
93ATP-dependent chromatin remodeling (GO:0043044)2.93375844
94protein targeting to membrane (GO:0006612)2.91862777
95translesion synthesis (GO:0019985)2.90249051
96negative regulation of erythrocyte differentiation (GO:0045647)2.89807678
97platelet dense granule organization (GO:0060155)2.88138934
98protein export from nucleus (GO:0006611)2.87871041
99regulation of centriole replication (GO:0046599)2.87405111
100chromatin assembly or disassembly (GO:0006333)2.86132289
101rRNA transcription (GO:0009303)2.84736652
102tRNA aminoacylation for protein translation (GO:0006418)2.83637620
103nuclear envelope organization (GO:0006998)2.83294482
104folic acid-containing compound biosynthetic process (GO:0009396)2.82973564
105lymphoid progenitor cell differentiation (GO:0002320)2.82843208
106RNA stabilization (GO:0043489)2.82103052
107mRNA stabilization (GO:0048255)2.82103052
108DNA replication-independent nucleosome assembly (GO:0006336)2.81731706
109DNA replication-independent nucleosome organization (GO:0034724)2.81731706
110regulation of spindle organization (GO:0090224)2.81595920
111pentose-phosphate shunt (GO:0006098)2.81475518
112chromatin assembly (GO:0031497)2.80403523
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80026792
114L-serine metabolic process (GO:0006563)2.79871503
115intra-S DNA damage checkpoint (GO:0031573)2.79301074
116DNA ligation (GO:0006266)2.78526624
117telomere maintenance (GO:0000723)2.77172496
118telomere organization (GO:0032200)2.76950420
119DNA replication-dependent nucleosome organization (GO:0034723)2.76264856
120DNA replication-dependent nucleosome assembly (GO:0006335)2.76264856
121regulation of translational elongation (GO:0006448)2.75595429
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74975156
123double-strand break repair via nonhomologous end joining (GO:0006303)2.74750417
124non-recombinational repair (GO:0000726)2.74750417
125establishment of chromosome localization (GO:0051303)2.74206777
126cellular component biogenesis (GO:0044085)2.74200531
127IMP biosynthetic process (GO:0006188)2.73746469
128establishment of integrated proviral latency (GO:0075713)2.72985591
129amino acid activation (GO:0043038)2.72877584
130tRNA aminoacylation (GO:0043039)2.72877584
131definitive hemopoiesis (GO:0060216)2.72597647
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.72461293
133regulation of sister chromatid cohesion (GO:0007063)2.71485931
134chromosome segregation (GO:0007059)2.70928437
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70752151
136regulation of chromosome segregation (GO:0051983)2.70377796
137termination of RNA polymerase II transcription (GO:0006369)2.70261994
138protein localization to chromosome, centromeric region (GO:0071459)2.69460051
139protein retention in ER lumen (GO:0006621)2.69090199
140protein localization to kinetochore (GO:0034501)2.68152162
141regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.66505734
142GDP-mannose metabolic process (GO:0019673)2.61236827
143transcription-coupled nucleotide-excision repair (GO:0006283)2.61055815
144somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60201723
145somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60201723
146isotype switching (GO:0045190)2.60201723
147IMP metabolic process (GO:0046040)2.59700204
148termination of RNA polymerase III transcription (GO:0006386)2.59369403
149transcription elongation from RNA polymerase III promoter (GO:0006385)2.59369403
150tRNA modification (GO:0006400)2.59107452
151ncRNA processing (GO:0034470)2.58731005
152respiratory chain complex IV assembly (GO:0008535)2.58304574
153histone exchange (GO:0043486)2.57217503
154viral mRNA export from host cell nucleus (GO:0046784)2.54703022
155purine nucleobase biosynthetic process (GO:0009113)2.53955502
156pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.53391051
157negative regulation of mRNA processing (GO:0050686)2.51875270
158mRNA splicing, via spliceosome (GO:0000398)2.51037675
159RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.51037675
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50777704
161mitochondrial DNA replication (GO:0006264)2.49611336
162RNA splicing, via transesterification reactions (GO:0000375)2.49517440
163response to interferon-beta (GO:0035456)2.49503448
164pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47915805
165histone mRNA metabolic process (GO:0008334)2.47373112
166ncRNA metabolic process (GO:0034660)2.47250605
167mitotic nuclear envelope disassembly (GO:0007077)2.47213825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48424130
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22222407
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95378523
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.16917208
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00347105
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90285728
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71280675
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69765617
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66814295
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.65981998
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.64104987
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.63372882
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59791193
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58558090
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.55729207
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52998803
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51132984
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47205543
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.43335846
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.37151668
21* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23285814
22XRN2_22483619_ChIP-Seq_HELA_Human2.22695238
23* VDR_23849224_ChIP-Seq_CD4+_Human2.22447243
24MYC_22102868_ChIP-Seq_BL_Human2.20748751
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.11707554
26SCL_19346495_ChIP-Seq_HPC-7_Human2.09517324
27FOXP3_21729870_ChIP-Seq_TREG_Human2.07341626
28* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06543230
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98960522
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93653597
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87850939
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.86350369
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84236742
34ZNF263_19887448_ChIP-Seq_K562_Human1.82857930
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82708022
36DCP1A_22483619_ChIP-Seq_HELA_Human1.81617685
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81585101
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81550214
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79735507
40TTF2_22483619_ChIP-Seq_HELA_Human1.77993414
41CIITA_25753668_ChIP-Seq_RAJI_Human1.77924033
42VDR_21846776_ChIP-Seq_THP-1_Human1.77853393
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76617991
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76116360
45* GABP_19822575_ChIP-Seq_HepG2_Human1.75629854
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74964708
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66614804
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66587186
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65598903
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63840979
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63086855
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.61360415
53* E2F1_21310950_ChIP-Seq_MCF-7_Human1.61306633
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59060840
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58512957
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57423623
57* SPI1_23547873_ChIP-Seq_NB4_Human1.54315159
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52276686
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51615308
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50279963
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49224512
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48135039
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.47598009
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.46301058
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44902036
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42268333
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41452914
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40129011
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39505822
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38266494
71ELK1_19687146_ChIP-ChIP_HELA_Human1.34132727
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30782312
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26159581
74AR_21909140_ChIP-Seq_LNCAP_Human1.26134708
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25063812
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.21829767
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21479501
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21424922
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.19062468
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.18163413
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16895964
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16801175
83MYB_26560356_Chip-Seq_TH2_Human1.15353610
84RACK7_27058665_Chip-Seq_MCF-7_Human1.14900376
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13859454
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12688983
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.12684742
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12659007
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.12361083
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12259313
91MAF_26560356_Chip-Seq_TH1_Human1.12232357
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11702370
93MYB_26560356_Chip-Seq_TH1_Human1.11040507
94VDR_24763502_ChIP-Seq_THP-1_Human1.09952042
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09754862
96KDM5A_27292631_Chip-Seq_BREAST_Human1.09305990
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07557582
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06367987
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05923394
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05788424
101CLOCK_20551151_ChIP-Seq_293T_Human1.05658556
102LXR_22292898_ChIP-Seq_THP-1_Human1.05163334
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04633003
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04525396
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03851753
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03238789
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03228213
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.03209221
109* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03117933
110CHD1_26751641_Chip-Seq_LNCaP_Human1.02919207
111* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02733764
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02662470
113UTX_26944678_Chip-Seq_JUKART_Human1.02631124
114* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02167807
115ATF3_27146783_Chip-Seq_COLON_Human1.01869870
116* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00992052
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.00204467
118MYC_18940864_ChIP-ChIP_HL60_Human0.99711538
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99065772
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97847354
121* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97546390
122* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97310616
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96127158
124* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91634896
125NCOR1_26117541_ChIP-Seq_K562_Human0.91609030
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90591865
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90141651
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90084854
129TFEB_21752829_ChIP-Seq_HELA_Human0.90062696
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89553660
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88579213
132MAF_26560356_Chip-Seq_TH2_Human0.87607986
133TCF7_22412390_ChIP-Seq_EML_Mouse0.87142665
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87039504
135FOXP1_21924763_ChIP-Seq_HESCs_Human0.86859120
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85960354
137GATA1_22025678_ChIP-Seq_K562_Human0.85552780
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85535082
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85485288
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85446567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.09665129
2MP0002396_abnormal_hematopoietic_system3.63136404
3MP0010094_abnormal_chromosome_stability3.38379634
4MP0009379_abnormal_foot_pigmentation3.27577435
5MP0004957_abnormal_blastocyst_morpholog3.00836189
6MP0005174_abnormal_tail_pigmentation2.96946001
7MP0008058_abnormal_DNA_repair2.90543857
8MP0003111_abnormal_nucleus_morphology2.85502048
9MP0000490_abnormal_crypts_of2.74592053
10MP0003077_abnormal_cell_cycle2.72354774
11MP0008057_abnormal_DNA_replication2.71129394
12MP0002877_abnormal_melanocyte_morpholog2.66812340
13MP0008007_abnormal_cellular_replicative2.57555398
14MP0001545_abnormal_hematopoietic_system2.45748950
15MP0005397_hematopoietic_system_phenotyp2.45748950
16MP0003705_abnormal_hypodermis_morpholog2.39464578
17MP0005451_abnormal_body_composition2.33497508
18MP0004808_abnormal_hematopoietic_stem2.28149509
19MP0005075_abnormal_melanosome_morpholog2.19811990
20MP0004233_abnormal_muscle_weight2.12496477
21MP0000685_abnormal_immune_system2.09553187
22MP0005076_abnormal_cell_differentiation2.03758275
23MP0006292_abnormal_olfactory_placode2.03222967
24MP0003763_abnormal_thymus_physiology2.02946155
25MP0009333_abnormal_splenocyte_physiolog1.96968128
26MP0001835_abnormal_antigen_presentation1.96424972
27MP0009672_abnormal_birth_weight1.92672025
28MP0000537_abnormal_urethra_morphology1.91783832
29MP0002398_abnormal_bone_marrow1.88410076
30MP0004185_abnormal_adipocyte_glucose1.88112501
31MP0002095_abnormal_skin_pigmentation1.84845058
32MP0010234_abnormal_vibrissa_follicle1.84721777
33MP0005671_abnormal_response_to1.78574537
34MP0004147_increased_porphyrin_level1.78540069
35MP0003786_premature_aging1.76706271
36MP0000015_abnormal_ear_pigmentation1.75818910
37MP0003984_embryonic_growth_retardation1.75306261
38MP0001188_hyperpigmentation1.68842964
39MP0000689_abnormal_spleen_morphology1.65903733
40MP0002088_abnormal_embryonic_growth/wei1.65732732
41MP0005501_abnormal_skin_physiology1.63823024
42MP0009785_altered_susceptibility_to1.61845862
43MP0002722_abnormal_immune_system1.61760210
44MP0000465_gastrointestinal_hemorrhage1.61373281
45MP0008932_abnormal_embryonic_tissue1.60998976
46MP0003566_abnormal_cell_adhesion1.59420181
47MP0001849_ear_inflammation1.57313446
48MP0010030_abnormal_orbit_morphology1.56633775
49MP0003724_increased_susceptibility_to1.55957799
50MP0002084_abnormal_developmental_patter1.53798606
51MP0006054_spinal_hemorrhage1.50962499
52MP0000678_abnormal_parathyroid_gland1.49065486
53MP0002796_impaired_skin_barrier1.48314510
54MP0005410_abnormal_fertilization1.47205173
55MP0002019_abnormal_tumor_incidence1.45570284
56MP0002429_abnormal_blood_cell1.43779437
57MP0000703_abnormal_thymus_morphology1.43428414
58MP0002086_abnormal_extraembryonic_tissu1.41581889
59MP0005409_darkened_coat_color1.41322607
60MP0000716_abnormal_immune_system1.40899259
61MP0005025_abnormal_response_to1.39945026
62MP0001800_abnormal_humoral_immune1.38105883
63MP0002210_abnormal_sex_determination1.35521327
64MP0002420_abnormal_adaptive_immunity1.34926286
65MP0000350_abnormal_cell_proliferation1.33771032
66MP0002132_abnormal_respiratory_system1.33467333
67MP0001819_abnormal_immune_cell1.32622496
68MP0004197_abnormal_fetal_growth/weight/1.32332202
69MP0000313_abnormal_cell_death1.30822074
70MP0001929_abnormal_gametogenesis1.30480319
71MP0002723_abnormal_immune_serum1.28952818
72MP0002452_abnormal_antigen_presenting1.26327472
73MP0002102_abnormal_ear_morphology1.25100026
74MP0001873_stomach_inflammation1.23994270
75MP0001853_heart_inflammation1.22548014
76MP0008877_abnormal_DNA_methylation1.21993940
77MP0002697_abnormal_eye_size1.21404849
78MP0003436_decreased_susceptibility_to1.20538872
79MP0003941_abnormal_skin_development1.19876178
80MP0005464_abnormal_platelet_physiology1.19005313
81MP0000681_abnormal_thyroid_gland1.15611640
82MP0001986_abnormal_taste_sensitivity1.15396410
83MP0010155_abnormal_intestine_physiology1.14377398
84MP0001145_abnormal_male_reproductive1.14355794
85MP0005000_abnormal_immune_tolerance1.13686146
86MP0003866_abnormal_defecation1.12451407
87MP0004264_abnormal_extraembryonic_tissu1.12361845
88MP0006035_abnormal_mitochondrial_morpho1.10677820
89MP0003718_maternal_effect1.10633864
90MP0008260_abnormal_autophagy1.10007271
91MP0001730_embryonic_growth_arrest1.06740449
92MP0003567_abnormal_fetal_cardiomyocyte1.06606658
93MP0002405_respiratory_system_inflammati1.06152811
94MP0005623_abnormal_meninges_morphology1.05819457
95MP0001661_extended_life_span1.05360393
96MP0002166_altered_tumor_susceptibility1.05170267
97MP0002148_abnormal_hypersensitivity_rea1.02067434
98MP0002080_prenatal_lethality1.01959765
99MP0003656_abnormal_erythrocyte_physiolo1.01924377
100MP0005384_cellular_phenotype1.01753505
101MP0001727_abnormal_embryo_implantation1.01125196
102MP0009697_abnormal_copulation1.00777161
103MP0003698_abnormal_male_reproductive1.00003663
104MP0001348_abnormal_lacrimal_gland0.99195815
105MP0005621_abnormal_cell_physiology0.98724041
106MP0002060_abnormal_skin_morphology0.96982104
107MP0002089_abnormal_postnatal_growth/wei0.95873155
108MP0009278_abnormal_bone_marrow0.94064925
109MP0000653_abnormal_sex_gland0.91912119
110MP0003115_abnormal_respiratory_system0.91666567
111MP0001346_abnormal_lacrimal_gland0.90890775
112MP0002092_abnormal_eye_morphology0.90152764
113MP0000477_abnormal_intestine_morphology0.89785474
114MP0004272_abnormal_basement_membrane0.89619507
115MP0000858_altered_metastatic_potential0.89427836
116MP0009053_abnormal_anal_canal0.88786848
117MP0003221_abnormal_cardiomyocyte_apopto0.88498669
118MP0003303_peritoneal_inflammation0.88190543
119MP0003942_abnormal_urinary_system0.86826096
120MP0003937_abnormal_limbs/digits/tail_de0.86591954
121MP0002111_abnormal_tail_morphology0.86386451
122MP0009703_decreased_birth_body0.86190580
123MP0005257_abnormal_intraocular_pressure0.86102738
124MP0003385_abnormal_body_wall0.85758352
125MP0003453_abnormal_keratinocyte_physiol0.84787194
126MP0000358_abnormal_cell_content/0.84574320
127MP0003123_paternal_imprinting0.84479609
128MP0001697_abnormal_embryo_size0.84364277
129MP0010307_abnormal_tumor_latency0.84000558
130MP0002160_abnormal_reproductive_system0.83742076
131MP0003868_abnormal_feces_composition0.83578714
132MP0000049_abnormal_middle_ear0.83281989
133MP0001293_anophthalmia0.83000735
134MP0003646_muscle_fatigue0.82210371
135MP0002938_white_spotting0.82110237
136MP0004858_abnormal_nervous_system0.81684806
137MP0002006_tumorigenesis0.81236030
138MP0000428_abnormal_craniofacial_morphol0.81192632
139MP0002075_abnormal_coat/hair_pigmentati0.80097071
140MP0002177_abnormal_outer_ear0.79646114
141MP0001915_intracranial_hemorrhage0.79528042
142MP0002419_abnormal_innate_immunity0.78897783
143MP0001216_abnormal_epidermal_layer0.78501825
144MP0000566_synostosis0.77318721
145MP0004782_abnormal_surfactant_physiolog0.76561007
146MP0000003_abnormal_adipose_tissue0.75965020
147MP0010352_gastrointestinal_tract_polyps0.75956700
148MP0000762_abnormal_tongue_morphology0.75872654
149MP0006036_abnormal_mitochondrial_physio0.75871301
150MP0003861_abnormal_nervous_system0.75474756
151MP0005666_abnormal_adipose_tissue0.75255190
152MP0003828_pulmonary_edema0.75020961
153MP0003315_abnormal_perineum_morphology0.74602819
154MP0002085_abnormal_embryonic_tissue0.73465166
155MP0002163_abnormal_gland_morphology0.72925995
156MP0001790_abnormal_immune_system0.72673558
157MP0005387_immune_system_phenotype0.72673558
158MP0005380_embryogenesis_phenotype0.72546570
159MP0001672_abnormal_embryogenesis/_devel0.72546570
160MP0001881_abnormal_mammary_gland0.70180810
161MP0000627_abnormal_mammary_gland0.69608704
162MP0003806_abnormal_nucleotide_metabolis0.69112073
163MP0010630_abnormal_cardiac_muscle0.68955539
164MP0000467_abnormal_esophagus_morphology0.68490280
165MP0001286_abnormal_eye_development0.67232738
166MP0000733_abnormal_muscle_development0.66952881
167MP0002249_abnormal_larynx_morphology0.66139907

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.23616204
2Abnormal number of erythroid precursors (HP:0012131)6.17641380
3Reduced antithrombin III activity (HP:0001976)5.52647687
4Type I transferrin isoform profile (HP:0003642)5.31994369
5Reticulocytopenia (HP:0001896)4.93904696
6Aplastic anemia (HP:0001915)4.59208894
7Hyperacusis (HP:0010780)4.00267898
8Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.97703235
9Abnormal protein N-linked glycosylation (HP:0012347)3.97703235
10Abnormal protein glycosylation (HP:0012346)3.97703235
11Abnormal glycosylation (HP:0012345)3.97703235
12Thrombocytosis (HP:0001894)3.96827653
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.94791255
14Pallor (HP:0000980)3.83418365
15Macrocytic anemia (HP:0001972)3.52215206
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.37544451
17Increased nuchal translucency (HP:0010880)3.36094398
18Thyroid-stimulating hormone excess (HP:0002925)3.32724332
19Insomnia (HP:0100785)3.25175939
20Muscle fiber atrophy (HP:0100295)3.16739029
21Birth length less than 3rd percentile (HP:0003561)3.16462114
22IgM deficiency (HP:0002850)3.15949256
23Severe visual impairment (HP:0001141)3.12462150
24Multiple enchondromatosis (HP:0005701)3.04525560
25Type 2 muscle fiber atrophy (HP:0003554)3.00944720
26Chronic otitis media (HP:0000389)2.90824315
27Petechiae (HP:0000967)2.86679786
28Trismus (HP:0000211)2.85056201
29Deviation of the thumb (HP:0009603)2.82514633
30Proximal placement of thumb (HP:0009623)2.81283231
31Oral leukoplakia (HP:0002745)2.80281830
32Overriding aorta (HP:0002623)2.75866270
33Nasal polyposis (HP:0100582)2.71746679
34Elevated erythrocyte sedimentation rate (HP:0003565)2.63904662
35Abnormality of the nasal mucosa (HP:0000433)2.63369462
36Myelodysplasia (HP:0002863)2.57179830
37Pancytopenia (HP:0001876)2.56316920
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55718082
39Hypothermia (HP:0002045)2.55150898
40Prolonged bleeding time (HP:0003010)2.54409285
41Elfin facies (HP:0004428)2.53018339
42Poikiloderma (HP:0001029)2.50140098
43Abnormal gallbladder physiology (HP:0012438)2.48005155
44Cholecystitis (HP:0001082)2.48005155
45Recurrent bronchitis (HP:0002837)2.47865737
46Renal duplication (HP:0000075)2.46303242
47Abnormal spermatogenesis (HP:0008669)2.45581902
48Progressive external ophthalmoplegia (HP:0000590)2.43018993
49Selective tooth agenesis (HP:0001592)2.38867791
50Overlapping toe (HP:0001845)2.37538481
51Abnormality of T cell physiology (HP:0011840)2.36936203
52Abnormality of glycolysis (HP:0004366)2.34586241
53Abnormality of the preputium (HP:0100587)2.33146942
54Absent thumb (HP:0009777)2.33093201
55Asymmetry of the thorax (HP:0001555)2.31045671
56Panhypogammaglobulinemia (HP:0003139)2.30606662
57Microretrognathia (HP:0000308)2.29680115
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29437236
59Acute lymphatic leukemia (HP:0006721)2.29161904
6011 pairs of ribs (HP:0000878)2.28419410
61Amaurosis fugax (HP:0100576)2.26567222
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24221518
63Broad distal phalanx of finger (HP:0009836)2.21171138
64Achilles tendon contracture (HP:0001771)2.20827980
65Ragged-red muscle fibers (HP:0003200)2.20380824
66Entropion (HP:0000621)2.19353034
67Microvesicular hepatic steatosis (HP:0001414)2.18148842
68Squamous cell carcinoma (HP:0002860)2.17852431
69Abnormality of reticulocytes (HP:0004312)2.17418029
70Abnormality of DNA repair (HP:0003254)2.16625011
71Long palpebral fissure (HP:0000637)2.16103782
72Acute myeloid leukemia (HP:0004808)2.15623573
73High anterior hairline (HP:0009890)2.15470803
74Abnormality of chromosome stability (HP:0003220)2.13209551
75Pendular nystagmus (HP:0012043)2.12290932
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11627366
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11627366
78Renovascular hypertension (HP:0100817)2.11250577
79Bone marrow hypocellularity (HP:0005528)2.10896372
80Patellar dislocation (HP:0002999)2.09369191
81Myositis (HP:0100614)2.09147643
82Progressive muscle weakness (HP:0003323)2.08942801
83Lymphoma (HP:0002665)2.08670597
84Meckel diverticulum (HP:0002245)2.08545668
85Spastic diplegia (HP:0001264)2.07627207
86Exertional dyspnea (HP:0002875)2.07248754
87Back pain (HP:0003418)2.07248032
88Colon cancer (HP:0003003)2.07092008
89Cortical dysplasia (HP:0002539)2.06721018
90Termporal pattern (HP:0011008)2.05930270
91Insidious onset (HP:0003587)2.05930270
92Chromsome breakage (HP:0040012)2.05630788
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04106021
94Ankle contracture (HP:0006466)2.03288554
95Nonprogressive disorder (HP:0003680)2.03058610
96Atresia of the external auditory canal (HP:0000413)2.03007103
97Progressive hearing impairment (HP:0001730)2.03003246
98Abnormality of the ileum (HP:0001549)2.02814210
99Rough bone trabeculation (HP:0100670)2.02504174
100Abnormal platelet function (HP:0011869)2.02244411
101Impaired platelet aggregation (HP:0003540)2.02244411
102Ankyloglossia (HP:0010296)2.01031368
103Ulnar bowing (HP:0003031)2.00854376
104Facial cleft (HP:0002006)1.99505979
105Horseshoe kidney (HP:0000085)1.98874368
106Absent epiphyses (HP:0010577)1.98693654
107Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98693654
108Hypoplasia of the radius (HP:0002984)1.98555831
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.96752757
110Epistaxis (HP:0000421)1.96479056
111Increased hepatocellular lipid droplets (HP:0006565)1.95565239
112Microcytic anemia (HP:0001935)1.95444036
113Urethral obstruction (HP:0000796)1.95258756
114Abnormality of the umbilical cord (HP:0010881)1.94136734
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92733720
116Abnormality of the Achilles tendon (HP:0005109)1.91978904
117Increased serum pyruvate (HP:0003542)1.91620883
118Bronchitis (HP:0012387)1.90685830
119Distal lower limb amyotrophy (HP:0008944)1.90515812
120Abnormality of the columella (HP:0009929)1.90153462
121Basal cell carcinoma (HP:0002671)1.90095231
122Premature graying of hair (HP:0002216)1.89417433
123B lymphocytopenia (HP:0010976)1.88525303
124Abnormality of B cell number (HP:0010975)1.88525303
125Glossoptosis (HP:0000162)1.88420673
126Abnormal rod and cone electroretinograms (HP:0008323)1.88368550
127Deep palmar crease (HP:0006191)1.87547684
128Missing ribs (HP:0000921)1.84833011
129IgG deficiency (HP:0004315)1.83904604
130Abnormality of cochlea (HP:0000375)1.83568890
131Abnormality of the carotid arteries (HP:0005344)1.83532774
132Unilateral renal agenesis (HP:0000122)1.83052739
133Reticulocytosis (HP:0001923)1.82386778
134Nephroblastoma (Wilms tumor) (HP:0002667)1.82052252
135Abnormal number of incisors (HP:0011064)1.81603200
136Distal upper limb amyotrophy (HP:0007149)1.81386297
137Upper limb amyotrophy (HP:0009129)1.81386297
138Abnormality of the calcaneus (HP:0008364)1.81201013
139Pointed chin (HP:0000307)1.81029235
140Medulloblastoma (HP:0002885)1.79590960
141Pulmonary fibrosis (HP:0002206)1.77611697
142Shoulder girdle muscle weakness (HP:0003547)1.76634421
143Abnormality of T cells (HP:0002843)1.75382099
144Abnormality of oral frenula (HP:0000190)1.74881857
145Supernumerary spleens (HP:0009799)1.74626562
146Orthostatic hypotension (HP:0001278)1.74468427
147Azoospermia (HP:0000027)1.74274702
148Neoplasm of the pancreas (HP:0002894)1.74253258
149Agnosia (HP:0010524)1.74233736
150Flat occiput (HP:0005469)1.73874275
151Recurrent viral infections (HP:0004429)1.72511181
152Cortical visual impairment (HP:0100704)1.72370385
153Sloping forehead (HP:0000340)1.72214670
154Clubbing of toes (HP:0100760)1.71583052
155Premature ovarian failure (HP:0008209)1.70990894
156Attenuation of retinal blood vessels (HP:0007843)1.70029693
157Respiratory difficulties (HP:0002880)1.70014716
158Small intestinal stenosis (HP:0012848)1.69738129
159Duodenal stenosis (HP:0100867)1.69738129
160Premature rupture of membranes (HP:0001788)1.69566247
161Vertebral compression fractures (HP:0002953)1.68637221
162Triphalangeal thumb (HP:0001199)1.68451672
163Breast hypoplasia (HP:0003187)1.68151645
164Microglossia (HP:0000171)1.66881709
165Choanal atresia (HP:0000453)1.66330372
166Pseudobulbar signs (HP:0002200)1.66215741
167Small epiphyses (HP:0010585)1.66148172
168Abnormality of the distal phalanges of the toes (HP:0010182)1.65833020
169Centrally nucleated skeletal muscle fibers (HP:0003687)1.64513444
170Short nail (HP:0001799)1.64395505
171Breech presentation (HP:0001623)1.63917961
172Preauricular skin tag (HP:0000384)1.62247395
173Upper limb muscle weakness (HP:0003484)1.61855607
174Septate vagina (HP:0001153)1.61720121
175Embryonal renal neoplasm (HP:0011794)1.61652847
176Hand muscle atrophy (HP:0009130)1.61195998
177Pelvic girdle muscle weakness (HP:0003749)1.60256004
178Disproportionate tall stature (HP:0001519)1.59528794
179Increased connective tissue (HP:0009025)1.59502434
180Obsessive-compulsive behavior (HP:0000722)1.59360927
181Arnold-Chiari malformation (HP:0002308)1.59299852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.79244724
2WEE13.82186100
3SMG13.44422376
4NME23.34304036
5CDK123.21623097
6STK163.14215454
7TRIB32.92998074
8BUB12.64668219
9MKNK22.62134450
10EIF2AK32.58687572
11NLK2.47274799
12MUSK2.42181317
13CDC72.36154787
14FLT32.24251201
15ICK2.20962069
16KIT2.20943175
17VRK22.19373042
18MKNK12.19191557
19ACVR1B2.11813776
20PBK1.98576893
21EPHA21.98480412
22NEK21.97072226
23NEK11.92150291
24DYRK31.91177199
25PIM21.80480022
26EIF2AK11.74034737
27BRSK21.74023455
28TEC1.68981374
29VRK11.60708408
30EEF2K1.59804065
31MAP4K11.58064035
32TLK11.57682077
33SRPK11.56925036
34MST1R1.56332512
35CDK191.50878770
36CDK71.48946971
37TGFBR11.45701532
38BTK1.37976860
39SCYL21.27024142
40FES1.23017034
41LATS21.22404021
42RPS6KB21.21864481
43PASK1.20359170
44CDK41.17259695
45BLK1.15564626
46KDR1.15271433
47CSF1R1.14535155
48FGFR41.12773215
49CAMKK21.11353653
50ATR1.08757044
51TESK21.07537581
52ALK1.06913780
53RPS6KA41.02831584
54ARAF1.02305751
55PRPF4B0.99675838
56SIK10.99437653
57ZAP700.97203336
58MAP2K30.94854069
59MTOR0.94638830
60PLK10.93830777
61EIF2AK20.93678478
62BRD40.91570805
63TAF10.90176677
64MATK0.89913912
65NME10.88194133
66PLK30.88028042
67BRAF0.86156620
68AURKB0.84699317
69PDGFRA0.84284986
70PTK20.82145176
71PIM10.80367968
72CAMK10.80146904
73CCNB10.78799972
74CLK10.78426081
75STK100.77486666
76MET0.77130520
77TGFBR20.73795444
78TTN0.73561009
79CDK10.72518843
80TTK0.71321430
81JAK30.70352176
82IRAK40.70236345
83PAK40.70058522
84CHEK20.69992864
85PLK40.69269803
86CDK80.68502667
87BRSK10.68023497
88ERBB40.67438716
89STK40.67386252
90MAP3K80.66590839
91TSSK60.65505745
92TAOK20.64843934
93AKT20.64325826
94KSR20.64155589
95MAP3K90.63969170
96PTK60.63150489
97LYN0.62844731
98MAP3K110.62431020
99LRRK20.61974975
100ILK0.60600641
101MAPKAPK30.60376130
102CDK90.58901046
103SYK0.58622676
104CDK11A0.57895653
105CSNK2A20.57640184
106TBK10.56177821
107AURKA0.55084814
108MAP2K20.54563112
109MAP3K100.53049108
110TIE10.50946564
111PRKCI0.50656763
112IKBKB0.50628871
113DAPK10.50207556
114LCK0.49661712
115CSNK2A10.48816886
116YES10.48278270
117CHEK10.48234546
118CDK150.48085235
119MAPK40.47532287
120CDK140.46275570
121TXK0.45810112
122CDK180.45368954
123TYK20.45285241
124NTRK10.44924157
125RAF10.44423661
126LMTK20.44417051
127PDK30.44293476
128PDK40.44293476
129PRKG20.43988875
130CSNK1E0.43244791
131PKN20.42827270
132ATM0.41178375
133IRAK30.40661039
134BMX0.40604438
135ERN10.40075185
136PAK10.39034317
137PAK20.39031554
138LIMK10.38654181
139CAMK1D0.38524712
140ADRBK20.38418906
141BCKDK0.37621137
142MAPK110.36656010
143TESK10.34125271
144MAPK140.32834137
145HIPK20.32529524
146MAP3K60.32227063
147CDK20.30902749
148CDK60.30400715
149RPS6KA50.29587147
150DYRK1B0.29397047

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.43449459
2Ribosome_Homo sapiens_hsa030104.51697683
3Mismatch repair_Homo sapiens_hsa034303.81770944
4Base excision repair_Homo sapiens_hsa034103.06292160
5Spliceosome_Homo sapiens_hsa030403.00639176
6Homologous recombination_Homo sapiens_hsa034402.99310234
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73092652
8RNA polymerase_Homo sapiens_hsa030202.71264326
9Nucleotide excision repair_Homo sapiens_hsa034202.66030310
10Pyrimidine metabolism_Homo sapiens_hsa002402.60395920
11RNA transport_Homo sapiens_hsa030132.24388250
12Proteasome_Homo sapiens_hsa030502.14745531
13Fanconi anemia pathway_Homo sapiens_hsa034602.10860845
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04851210
15Cell cycle_Homo sapiens_hsa041101.99900199
16One carbon pool by folate_Homo sapiens_hsa006701.94415965
17Non-homologous end-joining_Homo sapiens_hsa034501.87683654
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78963615
19Basal transcription factors_Homo sapiens_hsa030221.71217745
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67789900
21Sulfur relay system_Homo sapiens_hsa041221.64818850
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64384776
23Thyroid cancer_Homo sapiens_hsa052161.62667562
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58996490
25Carbon metabolism_Homo sapiens_hsa012001.56356766
26Protein export_Homo sapiens_hsa030601.54254942
27RNA degradation_Homo sapiens_hsa030181.53029289
28N-Glycan biosynthesis_Homo sapiens_hsa005101.49825747
29Primary immunodeficiency_Homo sapiens_hsa053401.44256204
30p53 signaling pathway_Homo sapiens_hsa041151.44059678
31Purine metabolism_Homo sapiens_hsa002301.43591172
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39000537
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36753171
34Herpes simplex infection_Homo sapiens_hsa051681.30859367
35Antigen processing and presentation_Homo sapiens_hsa046121.25448011
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21160251
37Bladder cancer_Homo sapiens_hsa052191.14705996
38Vitamin B6 metabolism_Homo sapiens_hsa007501.12943030
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12702318
40Folate biosynthesis_Homo sapiens_hsa007901.10833579
41Fructose and mannose metabolism_Homo sapiens_hsa000511.10283427
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08922390
43mRNA surveillance pathway_Homo sapiens_hsa030151.05244255
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03228236
45Pyruvate metabolism_Homo sapiens_hsa006201.03022026
46Acute myeloid leukemia_Homo sapiens_hsa052210.99109886
47Epstein-Barr virus infection_Homo sapiens_hsa051690.94107274
48Systemic lupus erythematosus_Homo sapiens_hsa053220.94016481
49Pancreatic cancer_Homo sapiens_hsa052120.92856306
50Measles_Homo sapiens_hsa051620.92232796
51Non-small cell lung cancer_Homo sapiens_hsa052230.90207875
52Hematopoietic cell lineage_Homo sapiens_hsa046400.89973530
53Pentose phosphate pathway_Homo sapiens_hsa000300.89960155
54Lysine degradation_Homo sapiens_hsa003100.89395345
55Adherens junction_Homo sapiens_hsa045200.83373102
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82461820
57MicroRNAs in cancer_Homo sapiens_hsa052060.82332775
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77355079
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77210926
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76596515
61B cell receptor signaling pathway_Homo sapiens_hsa046620.74820127
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71329375
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.70981903
64Viral carcinogenesis_Homo sapiens_hsa052030.70221329
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69415060
66Endometrial cancer_Homo sapiens_hsa052130.68689868
67Other glycan degradation_Homo sapiens_hsa005110.67635247
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64536563
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.64436806
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63180461
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.63008209
72HTLV-I infection_Homo sapiens_hsa051660.59569540
73Legionellosis_Homo sapiens_hsa051340.56424403
74Leishmaniasis_Homo sapiens_hsa051400.56163274
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.56087801
76Hippo signaling pathway_Homo sapiens_hsa043900.55926066
77Prostate cancer_Homo sapiens_hsa052150.55919026
78Steroid biosynthesis_Homo sapiens_hsa001000.55169622
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54216901
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53289704
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.52787640
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52167360
83Shigellosis_Homo sapiens_hsa051310.51493431
84Fatty acid elongation_Homo sapiens_hsa000620.51419077
85Hepatitis B_Homo sapiens_hsa051610.51073419
86Selenocompound metabolism_Homo sapiens_hsa004500.50742123
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50169944
88Small cell lung cancer_Homo sapiens_hsa052220.48726559
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48300485
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47635959
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.47079629
92Insulin signaling pathway_Homo sapiens_hsa049100.46895520
93Influenza A_Homo sapiens_hsa051640.46537621
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44692106
95Proteoglycans in cancer_Homo sapiens_hsa052050.44557523
96Glioma_Homo sapiens_hsa052140.44464705
97Arginine biosynthesis_Homo sapiens_hsa002200.44177006
98Apoptosis_Homo sapiens_hsa042100.43708019
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43381407
100Renal cell carcinoma_Homo sapiens_hsa052110.42633890
101Vibrio cholerae infection_Homo sapiens_hsa051100.41764178
102Prion diseases_Homo sapiens_hsa050200.41515960
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41414216
104VEGF signaling pathway_Homo sapiens_hsa043700.40445946
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39001545
106ErbB signaling pathway_Homo sapiens_hsa040120.38744715
107Tight junction_Homo sapiens_hsa045300.38585709
108Wnt signaling pathway_Homo sapiens_hsa043100.37762322
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37641600
110Colorectal cancer_Homo sapiens_hsa052100.36551583
111Allograft rejection_Homo sapiens_hsa053300.36535593
112Arginine and proline metabolism_Homo sapiens_hsa003300.35618771
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35354590
114AMPK signaling pathway_Homo sapiens_hsa041520.34712273
115Alcoholism_Homo sapiens_hsa050340.33457035
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33379370
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32843668
118Asthma_Homo sapiens_hsa053100.32754778
119Phenylalanine metabolism_Homo sapiens_hsa003600.31459707
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31065614
121Melanoma_Homo sapiens_hsa052180.30546467
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30527080
123mTOR signaling pathway_Homo sapiens_hsa041500.29134046
124Oocyte meiosis_Homo sapiens_hsa041140.28934718
125Chronic myeloid leukemia_Homo sapiens_hsa052200.26629670
126Glutathione metabolism_Homo sapiens_hsa004800.25449963
127Notch signaling pathway_Homo sapiens_hsa043300.25281210
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25203022
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24368512
130Malaria_Homo sapiens_hsa051440.23418830
131Platelet activation_Homo sapiens_hsa046110.23359275
132Pathways in cancer_Homo sapiens_hsa052000.22175352
133Biosynthesis of amino acids_Homo sapiens_hsa012300.21918550
134Arachidonic acid metabolism_Homo sapiens_hsa005900.21599521
135Metabolic pathways_Homo sapiens_hsa011000.20477687
136T cell receptor signaling pathway_Homo sapiens_hsa046600.20427703
137Toxoplasmosis_Homo sapiens_hsa051450.19496519
138Osteoclast differentiation_Homo sapiens_hsa043800.19234145
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18805557
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.17171812
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16555525
142Pertussis_Homo sapiens_hsa051330.14731866
143Basal cell carcinoma_Homo sapiens_hsa052170.14432386
144Huntingtons disease_Homo sapiens_hsa050160.13934984
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.13775287
146Galactose metabolism_Homo sapiens_hsa000520.13577574

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