PPM1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.22179783
2regulation of posttranscriptional gene silencing (GO:0060147)6.22179783
3regulation of gene silencing by miRNA (GO:0060964)6.22179783
4pre-miRNA processing (GO:0031054)5.34765272
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.30385626
6L-phenylalanine catabolic process (GO:0006559)5.30385626
7regulation of histone H3-K9 methylation (GO:0051570)5.29749115
8L-phenylalanine metabolic process (GO:0006558)5.14834389
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.14834389
10negative regulation of translation, ncRNA-mediated (GO:0040033)4.85839399
11regulation of translation, ncRNA-mediated (GO:0045974)4.85839399
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.85839399
13lysine catabolic process (GO:0006554)4.68773091
14lysine metabolic process (GO:0006553)4.68773091
15histone H3-K36 demethylation (GO:0070544)4.50786183
16alpha-linolenic acid metabolic process (GO:0036109)4.46488296
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.39362440
18aromatic amino acid family catabolic process (GO:0009074)4.38715931
19cysteine metabolic process (GO:0006534)4.35308851
20mitotic sister chromatid cohesion (GO:0007064)4.32583225
21dicarboxylic acid biosynthetic process (GO:0043650)4.25979903
22urea cycle (GO:0000050)4.15679749
23urea metabolic process (GO:0019627)4.15679749
24kynurenine metabolic process (GO:0070189)4.15484314
25sulfur amino acid catabolic process (GO:0000098)4.08535784
26regulation of meiosis I (GO:0060631)4.04533644
27glutamate metabolic process (GO:0006536)4.03987495
28negative regulation of histone methylation (GO:0031061)4.00375316
29regulation of cholesterol homeostasis (GO:2000188)3.98140957
30synapsis (GO:0007129)3.97968954
31regulation of DNA methylation (GO:0044030)3.96863826
32bile acid biosynthetic process (GO:0006699)3.92283451
33cytoplasmic mRNA processing body assembly (GO:0033962)3.91284956
34glyoxylate metabolic process (GO:0046487)3.88055534
35regulation of chromatin silencing (GO:0031935)3.87170818
36cellular ketone body metabolic process (GO:0046950)3.86883544
37aspartate family amino acid catabolic process (GO:0009068)3.86842825
38serine family amino acid catabolic process (GO:0009071)3.86768901
39paraxial mesoderm development (GO:0048339)3.77499879
402-oxoglutarate metabolic process (GO:0006103)3.76638954
41nitrogen cycle metabolic process (GO:0071941)3.74052133
42regulation of gene silencing (GO:0060968)3.70856334
43fatty acid transmembrane transport (GO:1902001)3.69826770
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68976429
45negative regulation of fibroblast apoptotic process (GO:2000270)3.68658081
46positive regulation of SMAD protein import into nucleus (GO:0060391)3.65084813
47carnitine shuttle (GO:0006853)3.63778055
48tryptophan catabolic process (GO:0006569)3.60591661
49indole-containing compound catabolic process (GO:0042436)3.60591661
50indolalkylamine catabolic process (GO:0046218)3.60591661
51homocysteine metabolic process (GO:0050667)3.58841889
52negative regulation of fibrinolysis (GO:0051918)3.57407099
53bile acid metabolic process (GO:0008206)3.56907610
54high-density lipoprotein particle remodeling (GO:0034375)3.56771036
55acylglycerol homeostasis (GO:0055090)3.56367866
56triglyceride homeostasis (GO:0070328)3.56367866
57histone H3-K9 demethylation (GO:0033169)3.55905136
58regulation of triglyceride catabolic process (GO:0010896)3.55602269
59amino-acid betaine metabolic process (GO:0006577)3.53164302
60alpha-amino acid catabolic process (GO:1901606)3.49691334
61acetyl-CoA metabolic process (GO:0006084)3.47173412
62monoubiquitinated protein deubiquitination (GO:0035520)3.44652572
63tryptophan metabolic process (GO:0006568)3.42075610
64complement activation, alternative pathway (GO:0006957)3.39252756
65cerebellar Purkinje cell differentiation (GO:0021702)3.38837223
66short-chain fatty acid metabolic process (GO:0046459)3.37578218
67regulation of fibrinolysis (GO:0051917)3.37271273
68nuclear pore complex assembly (GO:0051292)3.36680416
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.36410546
70cellular amino acid catabolic process (GO:0009063)3.32107072
71negative regulation of fatty acid biosynthetic process (GO:0045717)3.31325885
72negative regulation of inclusion body assembly (GO:0090084)3.30914516
73regulation of protein activation cascade (GO:2000257)3.30717375
74protein complex localization (GO:0031503)3.29114519
75nerve growth factor signaling pathway (GO:0038180)3.28627241
76negative regulation of gene silencing (GO:0060969)3.28418676
77ketone body metabolic process (GO:1902224)3.28198314
78protein carboxylation (GO:0018214)3.27754243
79peptidyl-glutamic acid carboxylation (GO:0017187)3.27754243
80sister chromatid cohesion (GO:0007062)3.27443348
81cellular modified amino acid catabolic process (GO:0042219)3.25021383
82sarcoplasmic reticulum calcium ion transport (GO:0070296)3.25016666
83drug catabolic process (GO:0042737)3.24006405
84fatty acid beta-oxidation (GO:0006635)3.21515065
85positive regulation of lipid catabolic process (GO:0050996)3.18862113
86regulation of bile acid biosynthetic process (GO:0070857)3.17673808
87reverse cholesterol transport (GO:0043691)3.15520116
88fatty acid homeostasis (GO:0055089)3.15476862
89cellular protein complex localization (GO:0034629)3.14430070
90fatty acid oxidation (GO:0019395)3.13237688
91DNA synthesis involved in DNA repair (GO:0000731)3.13146414
92mRNA stabilization (GO:0048255)3.12808159
93RNA stabilization (GO:0043489)3.12808159
94aromatic amino acid family metabolic process (GO:0009072)3.12779405
95nuclear pore organization (GO:0006999)3.12666840
96positive regulation of catenin import into nucleus (GO:0035413)3.12367477
97plasma lipoprotein particle clearance (GO:0034381)3.10511773
98tyrosine metabolic process (GO:0006570)3.08195022
99dicarboxylic acid catabolic process (GO:0043649)3.07703276
100regulation of complement activation (GO:0030449)3.07532511
101lipid oxidation (GO:0034440)3.07408393
102negative regulation of cholesterol transport (GO:0032375)3.05538747
103negative regulation of sterol transport (GO:0032372)3.05538747
104regulation of mRNA stability (GO:0043488)3.05412463
105interkinetic nuclear migration (GO:0022027)3.03671928
106ethanol oxidation (GO:0006069)3.03079988
107macroautophagy (GO:0016236)3.01616863
108protein-lipid complex remodeling (GO:0034368)3.01161407
109macromolecular complex remodeling (GO:0034367)3.01161407
110plasma lipoprotein particle remodeling (GO:0034369)3.01161407
111ncRNA catabolic process (GO:0034661)3.00334991
112histone lysine demethylation (GO:0070076)2.99796852
113carnitine transmembrane transport (GO:1902603)2.99550158
114amino-acid betaine transport (GO:0015838)2.98606699
115carnitine transport (GO:0015879)2.98606699
116fatty acid catabolic process (GO:0009062)2.98551995
117cerebellar granule cell differentiation (GO:0021707)2.98475589
118positive regulation of fatty acid oxidation (GO:0046321)2.98265123
119coenzyme catabolic process (GO:0009109)2.97243625
120phospholipid homeostasis (GO:0055091)2.96326239
121regulation of fatty acid beta-oxidation (GO:0031998)2.95876376
122monocarboxylic acid catabolic process (GO:0072329)2.93456272
123regulation of DNA endoreduplication (GO:0032875)2.92620317
124positive regulation of histone methylation (GO:0031062)2.92355365
125NLS-bearing protein import into nucleus (GO:0006607)2.90752155
126bile acid and bile salt transport (GO:0015721)2.90347940
127organic acid catabolic process (GO:0016054)2.89711174
128carboxylic acid catabolic process (GO:0046395)2.89711174
129intestinal cholesterol absorption (GO:0030299)2.89508054
130negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88251280
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.87892377
132serine family amino acid metabolic process (GO:0009069)2.86895861
133histone demethylation (GO:0016577)2.86739816
134histone H3-K4 trimethylation (GO:0080182)2.86706215
135positive regulation of histone H3-K4 methylation (GO:0051571)2.86608586
136phospholipid efflux (GO:0033700)2.86021610
137negative regulation of potassium ion transmembrane transport (GO:1901380)2.84377458
138regulation of NFAT protein import into nucleus (GO:0051532)2.84346778
139positive regulation of glycolytic process (GO:0045821)2.82748049
140valine metabolic process (GO:0006573)2.82614135
141cholesterol efflux (GO:0033344)2.82552449
142L-amino acid import (GO:0043092)2.82245564
143glycine metabolic process (GO:0006544)2.81746278
144carnitine metabolic process (GO:0009437)2.80927669
145presynaptic membrane assembly (GO:0097105)2.80190184
146drug transmembrane transport (GO:0006855)2.79973596
147acylglycerol catabolic process (GO:0046464)2.77587786
148neutral lipid catabolic process (GO:0046461)2.77587786
149positive regulation of microtubule polymerization (GO:0031116)2.77509166
150regulation of fatty acid biosynthetic process (GO:0042304)2.76807714
151regulation of RNA stability (GO:0043487)2.76762967
152positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76161710
153regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76161710
154exogenous drug catabolic process (GO:0042738)2.75964944
155tricarboxylic acid metabolic process (GO:0072350)2.75439059
156plasma lipoprotein particle assembly (GO:0034377)2.75085715
157ionotropic glutamate receptor signaling pathway (GO:0035235)2.71414310
158protein K11-linked deubiquitination (GO:0035871)2.71249683
159protein K63-linked deubiquitination (GO:0070536)2.70585060
160chromosome organization involved in meiosis (GO:0070192)2.68888326
161cell communication by electrical coupling (GO:0010644)2.68617524
162regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67380180
163cell fate commitment involved in formation of primary germ layer (GO:0060795)2.67153995
164regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62526263
165histone H4-K16 acetylation (GO:0043984)2.60971519
166regulation of synaptic vesicle exocytosis (GO:2000300)2.60790175
167regulation of axon regeneration (GO:0048679)2.58893774
168regulation of neuron projection regeneration (GO:0070570)2.58893774
169alternative mRNA splicing, via spliceosome (GO:0000380)2.58241227
170regulation of centriole replication (GO:0046599)2.57775793
171regulation of cell fate specification (GO:0042659)2.55866390
172protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.55772321
173regulation of protein polyubiquitination (GO:1902914)2.52992087
174presynaptic membrane organization (GO:0097090)2.52856731
175IMP metabolic process (GO:0046040)2.52595987
176negative regulation of histone modification (GO:0031057)2.52303906
177negative regulation of neurotransmitter transport (GO:0051589)2.52097343
178righting reflex (GO:0060013)2.52016297
179acrosome assembly (GO:0001675)2.51624750
180anterior/posterior axis specification, embryo (GO:0008595)2.50996126
181chromatin silencing (GO:0006342)2.50167563
182establishment of integrated proviral latency (GO:0075713)2.49596345
183regulation of histone methylation (GO:0031060)2.49389296
184mitotic G2/M transition checkpoint (GO:0044818)2.46987464
185synaptonemal complex organization (GO:0070193)2.45301888
186positive regulation of cellular response to oxidative stress (GO:1900409)2.42702092
187positive regulation of response to oxidative stress (GO:1902884)2.42702092
188negative regulation of chromatin modification (GO:1903309)2.42065658
189regulation of SMAD protein import into nucleus (GO:0060390)2.41559509
190regulation of RNA export from nucleus (GO:0046831)2.41542946
191male meiosis I (GO:0007141)2.41542755
192positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.41127189
193regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.41127189
194muscle filament sliding (GO:0030049)2.40578043
195actin-myosin filament sliding (GO:0033275)2.40578043
196histone H3-K4 methylation (GO:0051568)2.38212356
197protein dealkylation (GO:0008214)2.38034215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.05295095
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.33868973
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.56935643
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.50463347
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.47472141
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.35831492
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.19822786
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.02454773
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.02454773
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.02454773
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.96474581
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.75197358
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51295627
14TAF15_26573619_Chip-Seq_HEK293_Human2.42074734
15ZNF263_19887448_ChIP-Seq_K562_Human2.41666673
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28693693
17GBX2_23144817_ChIP-Seq_PC3_Human2.26734218
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.25424324
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24218364
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14800373
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13583678
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11713596
23FUS_26573619_Chip-Seq_HEK293_Human2.02141383
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93590621
25E2F7_22180533_ChIP-Seq_HELA_Human1.89888664
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85058115
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.83483816
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79540750
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79540750
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.75841392
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.73930315
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.73462327
33P300_19829295_ChIP-Seq_ESCs_Human1.68744216
34CLOCK_20551151_ChIP-Seq_293T_Human1.67314069
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56563646
36EWS_26573619_Chip-Seq_HEK293_Human1.53672222
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52957183
38* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52528238
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49886415
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48727975
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48686187
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45818025
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44219174
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42357747
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.40875061
46STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40812635
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40795210
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40757003
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39068950
50TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38215470
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37782749
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37590332
53* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36581157
54AR_21572438_ChIP-Seq_LNCaP_Human1.34113901
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33404810
56* TCF4_23295773_ChIP-Seq_U87_Human1.32807745
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32412099
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32101309
59SMAD4_21799915_ChIP-Seq_A2780_Human1.30906040
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29534837
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29491923
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29445863
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.26392666
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.23608184
65PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.22861601
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22715280
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.22714520
68* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22203752
69* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21721542
70POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21253938
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.20065692
72HNF4A_19822575_ChIP-Seq_HepG2_Human1.19700662
73STAT3_18555785_ChIP-Seq_MESCs_Mouse1.19368045
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19274438
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18867922
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18011717
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18002538
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17841548
79CBP_20019798_ChIP-Seq_JUKART_Human1.17841548
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17479846
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.16550879
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.16517795
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14184473
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13587742
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13361626
86CREB1_26743006_Chip-Seq_LNCaP_Human1.13205386
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13198104
88KDM2B_26808549_Chip-Seq_K562_Human1.11169071
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09986395
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.09964209
91DROSHA_22980978_ChIP-Seq_HELA_Human1.09144053
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08502418
93EZH2_22144423_ChIP-Seq_EOC_Human1.08354067
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08254217
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.07216511
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06418194
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.06278935
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.06278935
99REST_21632747_ChIP-Seq_MESCs_Mouse1.05395796
100* GF1_26923725_Chip-Seq_HPCs_Mouse1.05232620
101* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05067977
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04849252
103IGF1R_20145208_ChIP-Seq_DFB_Human1.04383747
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04150068
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03971280
106RUNX2_22187159_ChIP-Seq_PCA_Human1.03144732
107GATA1_22025678_ChIP-Seq_K562_Human1.02825123
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.02280881
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02276698
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02247863
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01138526
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00470486
113* BCAT_22108803_ChIP-Seq_LS180_Human1.00352595
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00330972
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00158688
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.00142550
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99901248
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99403275
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98459982
120* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98066115
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97979101
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.97777374
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96786725
124NANOG_16518401_ChIP-PET_MESCs_Mouse0.96634650
125* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96356656
126ZNF274_21170338_ChIP-Seq_K562_Hela0.95403673
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94972250
128* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93160583
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92713819
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.92392025
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92068601
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91898439
133* REST_18959480_ChIP-ChIP_MESCs_Mouse0.91125540
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.89805426
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89761312
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88691514
137GATA1_19941826_ChIP-Seq_K562_Human0.88358409
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86845358
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86802820
140* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86688385
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.86283344
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86077232
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.83811841
144KDM2B_26808549_Chip-Seq_DND41_Human0.83113779
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82944611
146* AR_19668381_ChIP-Seq_PC3_Human0.82595846
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82517491
148STAT3_23295773_ChIP-Seq_U87_Human0.80946311
149SALL1_21062744_ChIP-ChIP_HESCs_Human0.80775172
150CTCF_27219007_Chip-Seq_Bcells_Human0.80355223
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80288648
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80160880
153* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79528646
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79219697
155TBX3_20139965_ChIP-Seq_MESCs_Mouse0.78552875
156* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78284866
157NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.77971580
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.77534677
159* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77102527
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.76706695
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76626889
162* ATF3_27146783_Chip-Seq_COLON_Human0.76414981
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.75138269
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74646177
165AHR_22903824_ChIP-Seq_MCF-7_Human0.74354263
166ZFP281_27345836_Chip-Seq_ESCs_Mouse0.74070060
167KLF4_19829295_ChIP-Seq_ESCs_Human0.74012016
168WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73567113
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72637134
170SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.72150193
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.71897285
172POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71472968
173HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70865273
174GATA6_25053715_ChIP-Seq_YYC3_Human0.70503912
175* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.70298579
176* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69181406
177TP53_16413492_ChIP-PET_HCT116_Human0.68168298
178* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.68134073
179SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68124485
180* CDX2_22108803_ChIP-Seq_LS180_Human0.68019027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.04090900
2MP0005360_urolithiasis5.53754809
3MP0008877_abnormal_DNA_methylation5.03239635
4MP0005085_abnormal_gallbladder_physiolo4.91550593
5MP0005365_abnormal_bile_salt4.74335727
6MP0008057_abnormal_DNA_replication4.19485884
7MP0008875_abnormal_xenobiotic_pharmacok3.47217535
8MP0003252_abnormal_bile_duct3.22289878
9MP0003806_abnormal_nucleotide_metabolis3.01976383
10MP0010329_abnormal_lipoprotein_level2.74466791
11MP0003890_abnormal_embryonic-extraembry2.72494388
12MP0002837_dystrophic_cardiac_calcinosis2.72009397
13MP0002254_reproductive_system_inflammat2.48372213
14MP0003787_abnormal_imprinting2.47939972
15MP0005083_abnormal_biliary_tract2.30949444
16MP0004130_abnormal_muscle_cell2.20630038
17MP0000569_abnormal_digit_pigmentation2.15767643
18MP0003195_calcinosis2.13998972
19MP0005332_abnormal_amino_acid2.11351278
20MP0002009_preneoplasia2.09301693
21MP0009840_abnormal_foam_cell2.05857183
22MP0001666_abnormal_nutrient_absorption2.04894062
23MP0003705_abnormal_hypodermis_morpholog2.02331382
24MP0003941_abnormal_skin_development1.99518223
25MP0010234_abnormal_vibrissa_follicle1.97638638
26MP0001188_hyperpigmentation1.90120773
27MP0002118_abnormal_lipid_homeostasis1.86431087
28MP0003646_muscle_fatigue1.82637406
29MP0004043_abnormal_pH_regulation1.82348303
30MP0009703_decreased_birth_body1.80716782
31MP0003868_abnormal_feces_composition1.73478738
32MP0003567_abnormal_fetal_cardiomyocyte1.72378393
33MP0004145_abnormal_muscle_electrophysio1.71030880
34MP0000609_abnormal_liver_physiology1.69360023
35MP0004185_abnormal_adipocyte_glucose1.67239702
36MP0004957_abnormal_blastocyst_morpholog1.65948100
37MP0002272_abnormal_nervous_system1.64970324
38MP0004742_abnormal_vestibular_system1.63470429
39MP0002909_abnormal_adrenal_gland1.62897901
40MP0005076_abnormal_cell_differentiation1.61192337
41MP0000751_myopathy1.58965391
42MP0005666_abnormal_adipose_tissue1.53895604
43MP0010307_abnormal_tumor_latency1.51893956
44MP0001486_abnormal_startle_reflex1.51726411
45MP0002269_muscular_atrophy1.49791042
46MP0004484_altered_response_of1.46182961
47MP0004036_abnormal_muscle_relaxation1.46001843
48MP0003693_abnormal_embryo_hatching1.44778043
49MP0009745_abnormal_behavioral_response1.42691400
50MP0002971_abnormal_brown_adipose1.41886962
51MP0003121_genomic_imprinting1.40230061
52MP0004019_abnormal_vitamin_homeostasis1.37839218
53MP0002078_abnormal_glucose_homeostasis1.36897949
54MP0000747_muscle_weakness1.36892105
55MP0001730_embryonic_growth_arrest1.35757804
56MP0008961_abnormal_basal_metabolism1.35039993
57MP0001177_atelectasis1.34561551
58MP0004270_analgesia1.32118178
59MP0005187_abnormal_penis_morphology1.30024569
60MP0009780_abnormal_chondrocyte_physiolo1.29883796
61MP0008569_lethality_at_weaning1.28524508
62MP0004087_abnormal_muscle_fiber1.28146992
63MP0004215_abnormal_myocardial_fiber1.27999620
64MP0001440_abnormal_grooming_behavior1.27118694
65MP0002063_abnormal_learning/memory/cond1.25394253
66MP0003329_amyloid_beta_deposits1.25316671
67MP0005319_abnormal_enzyme/_coenzyme1.22949807
68MP0002064_seizures1.21938030
69MP0004084_abnormal_cardiac_muscle1.18122254
70MP0003191_abnormal_cellular_cholesterol1.15952993
71MP0005330_cardiomyopathy1.15249955
72MP0006036_abnormal_mitochondrial_physio1.13912784
73MP0005535_abnormal_body_temperature1.13670184
74MP0003123_paternal_imprinting1.12860737
75MP0001501_abnormal_sleep_pattern1.12655509
76MP0004859_abnormal_synaptic_plasticity1.12449632
77MP0004233_abnormal_muscle_weight1.12237477
78MP0005375_adipose_tissue_phenotype1.11479322
79MP0002067_abnormal_sensory_capabilities1.11280845
80MP0002138_abnormal_hepatobiliary_system1.10896029
81MP0002877_abnormal_melanocyte_morpholog1.10534163
82MP0005451_abnormal_body_composition1.10442752
83MP0005584_abnormal_enzyme/coenzyme_acti1.10044173
84MP0010352_gastrointestinal_tract_polyps1.08644984
85MP0003718_maternal_effect1.08458873
86MP0002736_abnormal_nociception_after1.07005094
87MP0003119_abnormal_digestive_system1.03987117
88MP0008058_abnormal_DNA_repair1.03924638
89MP0003111_abnormal_nucleus_morphology1.03735147
90MP0002210_abnormal_sex_determination1.03686147
91MP0004264_abnormal_extraembryonic_tissu1.03369798
92MP0004197_abnormal_fetal_growth/weight/1.03265678
93MP0003122_maternal_imprinting1.00762137
94MP0002084_abnormal_developmental_patter0.96722246
95MP0000013_abnormal_adipose_tissue0.95348502
96MP0005380_embryogenesis_phenotype0.93206388
97MP0001672_abnormal_embryogenesis/_devel0.93206388
98MP0003698_abnormal_male_reproductive0.92927080
99MP0005423_abnormal_somatic_nervous0.92859907
100MP0002088_abnormal_embryonic_growth/wei0.92086238
101MP0004811_abnormal_neuron_physiology0.91886114
102MP0003984_embryonic_growth_retardation0.91680899
103MP0000749_muscle_degeneration0.91537382
104MP0005620_abnormal_muscle_contractility0.91178060
105MP0009643_abnormal_urine_homeostasis0.91043053
106MP0001944_abnormal_pancreas_morphology0.90635727
107MP0005334_abnormal_fat_pad0.90085341
108MP0000003_abnormal_adipose_tissue0.89831270
109MP0005266_abnormal_metabolism0.88043006
110MP0000428_abnormal_craniofacial_morphol0.86655230
111MP0001929_abnormal_gametogenesis0.86473152
112MP0001145_abnormal_male_reproductive0.85547840
113MP0000350_abnormal_cell_proliferation0.84933270
114MP0001485_abnormal_pinna_reflex0.83877900
115MP0003300_gastrointestinal_ulcer0.83297202
116MP0002734_abnormal_mechanical_nocicepti0.83080012
117MP0010094_abnormal_chromosome_stability0.82961290
118MP0002106_abnormal_muscle_physiology0.82532954
119MP0002822_catalepsy0.82246104
120MP0004885_abnormal_endolymph0.82094760
121MP0001697_abnormal_embryo_size0.81740679
122MP0005670_abnormal_white_adipose0.80958373
123MP0000604_amyloidosis0.80720221
124MP0001984_abnormal_olfaction0.79812964
125MP0010630_abnormal_cardiac_muscle0.79288291
126MP0006072_abnormal_retinal_apoptosis0.78818335
127MP0003283_abnormal_digestive_organ0.78777177
128MP0000759_abnormal_skeletal_muscle0.78354495
129MP0002152_abnormal_brain_morphology0.77642980
130MP0003136_yellow_coat_color0.77425382
131MP0000653_abnormal_sex_gland0.77123639
132MP0005551_abnormal_eye_electrophysiolog0.77067013
133MP0003635_abnormal_synaptic_transmissio0.76549806
134MP0003861_abnormal_nervous_system0.76449390
135MP0000778_abnormal_nervous_system0.76299141
136MP0003656_abnormal_erythrocyte_physiolo0.76284063
137MP0003077_abnormal_cell_cycle0.76040821
138MP0009046_muscle_twitch0.75930912
139MP0003880_abnormal_central_pattern0.74834492
140MP0002693_abnormal_pancreas_physiology0.73239382
141MP0001299_abnormal_eye_distance/0.73162284
142MP0009672_abnormal_birth_weight0.72765505
143MP0000631_abnormal_neuroendocrine_gland0.72671494
144MP0003699_abnormal_female_reproductive0.71889441
145* MP0002085_abnormal_embryonic_tissue0.71567636
146MP0002086_abnormal_extraembryonic_tissu0.71172888
147MP0003137_abnormal_impulse_conducting0.70563298
148MP0001765_abnormal_ion_homeostasis0.70381289
149MP0003221_abnormal_cardiomyocyte_apopto0.69860782
150MP0002066_abnormal_motor_capabilities/c0.69755314
151MP0004085_abnormal_heartbeat0.69177338
152MP0008775_abnormal_heart_ventricle0.68886208
153MP0005448_abnormal_energy_balance0.68562447
154MP0002796_impaired_skin_barrier0.67762662
155MP0001764_abnormal_homeostasis0.66970064
156MP0003953_abnormal_hormone_level0.66593102
157MP0003633_abnormal_nervous_system0.66092460
158MP0003690_abnormal_glial_cell0.64790437
159MP0000598_abnormal_liver_morphology0.64705468
160MP0002332_abnormal_exercise_endurance0.64013157
161MP0003045_fibrosis0.63819019
162MP0000639_abnormal_adrenal_gland0.63416245
163MP0005369_muscle_phenotype0.62865062
164MP0002972_abnormal_cardiac_muscle0.61469002
165MP0006035_abnormal_mitochondrial_morpho0.60565840
166MP0008874_decreased_physiological_sensi0.60022899
167MP0001661_extended_life_span0.59589728
168MP0002229_neurodegeneration0.59274123
169MP0005636_abnormal_mineral_homeostasis0.59193165

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.04667925
2Deep venous thrombosis (HP:0002625)4.85208458
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.67632540
4Hypoglycemic coma (HP:0001325)4.37520489
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.29360744
6Xanthomatosis (HP:0000991)4.28691940
7Nemaline bodies (HP:0003798)4.13596938
8Ketosis (HP:0001946)4.10776266
9Hypobetalipoproteinemia (HP:0003563)4.07650603
10Ketoacidosis (HP:0001993)3.95968735
11Rimmed vacuoles (HP:0003805)3.93808341
12Hepatoblastoma (HP:0002884)3.74470047
13Exercise-induced myalgia (HP:0003738)3.58882539
14Hyperlipoproteinemia (HP:0010980)3.57692647
15Hyperinsulinemic hypoglycemia (HP:0000825)3.56358932
16Hypolipoproteinemia (HP:0010981)3.47946400
17Hyperammonemia (HP:0001987)3.46119527
18Hyperglycinemia (HP:0002154)3.39556496
19Hyperglycinuria (HP:0003108)3.39147280
20Hypoalphalipoproteinemia (HP:0003233)3.38290042
21Septo-optic dysplasia (HP:0100842)3.37299797
22Epidermoid cyst (HP:0200040)3.30919093
23Abnormality of the left ventricular outflow tract (HP:0011103)3.29286371
24Subaortic stenosis (HP:0001682)3.29286371
25Biliary tract neoplasm (HP:0100574)3.24782527
26Myoglobinuria (HP:0002913)3.24780038
27Abnormality of serine family amino acid metabolism (HP:0010894)3.21193016
28Abnormality of glycine metabolism (HP:0010895)3.21193016
29Prolonged partial thromboplastin time (HP:0003645)3.19346467
30Febrile seizures (HP:0002373)3.14024136
31Atonic seizures (HP:0010819)3.13061865
32Urinary bladder sphincter dysfunction (HP:0002839)3.11243690
33Hyperglycemia (HP:0003074)3.10050368
34Complement deficiency (HP:0004431)3.07958557
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06347053
36Hypoglycemic seizures (HP:0002173)3.03608587
37Muscle fiber splitting (HP:0003555)2.98518292
38Abnormality of the common coagulation pathway (HP:0010990)2.85758109
39Gout (HP:0001997)2.85270806
40Skin nodule (HP:0200036)2.82664417
41Hyporeflexia of lower limbs (HP:0002600)2.81952030
42Abnormality of the labia minora (HP:0012880)2.78187748
43Abnormality of the septum pellucidum (HP:0007375)2.76847829
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76698316
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.76686386
46Nephroblastoma (Wilms tumor) (HP:0002667)2.75972096
47Exercise-induced muscle cramps (HP:0003710)2.73618131
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.71789020
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.71789020
50Papillary thyroid carcinoma (HP:0002895)2.71774185
51Impaired vibration sensation in the lower limbs (HP:0002166)2.68063618
52Action tremor (HP:0002345)2.61642128
53Volvulus (HP:0002580)2.57928152
54Embryonal renal neoplasm (HP:0011794)2.57276359
55Gaze-evoked nystagmus (HP:0000640)2.57273033
56Hypochromic microcytic anemia (HP:0004840)2.56368598
57Conjugated hyperbilirubinemia (HP:0002908)2.54626795
58Dysmetric saccades (HP:0000641)2.52423951
59Shoulder girdle muscle weakness (HP:0003547)2.52181163
60Fat malabsorption (HP:0002630)2.49621831
61Late onset (HP:0003584)2.47723078
62Global brain atrophy (HP:0002283)2.46139042
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44325121
64Malignant gastrointestinal tract tumors (HP:0006749)2.43902723
65Gastrointestinal carcinoma (HP:0002672)2.43902723
66Pelvic girdle muscle weakness (HP:0003749)2.42968521
67Abnormality of the corticospinal tract (HP:0002492)2.42734680
68Abnormality of purine metabolism (HP:0004352)2.41249846
69Abnormality of the intrinsic pathway (HP:0010989)2.39510253
70Genetic anticipation (HP:0003743)2.38028898
71Progressive cerebellar ataxia (HP:0002073)2.36566260
72Abnormality of the lower motor neuron (HP:0002366)2.35723571
73Abnormality of fatty-acid metabolism (HP:0004359)2.34827875
74Difficulty running (HP:0009046)2.32869838
75Cholelithiasis (HP:0001081)2.32712239
76Absence seizures (HP:0002121)2.31923017
77Stomach cancer (HP:0012126)2.31752022
78Hypercholesterolemia (HP:0003124)2.31196302
79Postural instability (HP:0002172)2.30155919
80Dialeptic seizures (HP:0011146)2.29954845
81Acanthocytosis (HP:0001927)2.29569121
82Abnormal gallbladder morphology (HP:0012437)2.29392060
83Urinary urgency (HP:0000012)2.29334234
84Maternal diabetes (HP:0009800)2.29001250
85Sudden death (HP:0001699)2.28736730
86Protruding tongue (HP:0010808)2.28118678
87Neoplasm of the small intestine (HP:0100833)2.27521862
88Abnormality of endocrine pancreas physiology (HP:0012093)2.25530515
89Abnormality of the pancreatic islet cells (HP:0006476)2.25530515
90Status epilepticus (HP:0002133)2.23480770
91Hyperbilirubinemia (HP:0002904)2.23440535
92Abnormality of methionine metabolism (HP:0010901)2.23314228
93Absent septum pellucidum (HP:0001331)2.22957267
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19865087
95Chronic bronchitis (HP:0004469)2.19530277
96Gonadotropin excess (HP:0000837)2.18664160
97Metabolic acidosis (HP:0001942)2.18616840
98Abnormality of the hip-girdle musculature (HP:0001445)2.18090966
99Abnormality of the musculature of the pelvis (HP:0001469)2.18090966
100Broad-based gait (HP:0002136)2.17544923
101Bundle branch block (HP:0011710)2.16134874
102Back pain (HP:0003418)2.16011908
103Focal motor seizures (HP:0011153)2.15171720
104Impaired vibratory sensation (HP:0002495)2.15165961
105Pancreatic islet-cell hyperplasia (HP:0004510)2.12874062
106Abnormal gallbladder physiology (HP:0012438)2.12049497
107Cholecystitis (HP:0001082)2.12049497
108EMG: myopathic abnormalities (HP:0003458)2.10988807
109Abnormality of the Achilles tendon (HP:0005109)2.10651751
1102-3 toe syndactyly (HP:0004691)2.09586999
111Insulin-resistant diabetes mellitus (HP:0000831)2.08583880
112Muscle hypertrophy of the lower extremities (HP:0008968)2.08042790
113EMG: neuropathic changes (HP:0003445)2.07171659
114Abnormality of nucleobase metabolism (HP:0010932)2.06184925
115Aplasia involving bones of the extremities (HP:0009825)2.04478170
116Aplasia involving bones of the upper limbs (HP:0009823)2.04478170
117Aplasia of the phalanges of the hand (HP:0009802)2.04478170
118Transitional cell carcinoma of the bladder (HP:0006740)2.04089590
119Symptomatic seizures (HP:0011145)2.03637218
120Inappropriate behavior (HP:0000719)2.02830191
121Spastic diplegia (HP:0001264)2.02774433
122Leiomyosarcoma (HP:0100243)2.02072254
123Uterine leiomyosarcoma (HP:0002891)2.02072254
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.00482914
125Muscle fiber inclusion bodies (HP:0100299)2.00070456
126Calf muscle hypertrophy (HP:0008981)2.00028803
127Abnormality of serum amino acid levels (HP:0003112)1.99220045
128Aqueductal stenosis (HP:0002410)1.98949340
129Focal seizures (HP:0007359)1.98107812
130Abnormality of complement system (HP:0005339)1.97866508
131T lymphocytopenia (HP:0005403)1.97806052
132Type 1 muscle fiber predominance (HP:0003803)1.97785869
133Increased purine levels (HP:0004368)1.97301207
134Hyperuricemia (HP:0002149)1.97301207
135Rhabdomyolysis (HP:0003201)1.96633370
136Supernumerary spleens (HP:0009799)1.95814612
137Neonatal hypoglycemia (HP:0001998)1.95769455
138Germ cell neoplasia (HP:0100728)1.94691871
139Abnormal biliary tract morphology (HP:0012440)1.93130172
140Turricephaly (HP:0000262)1.92795166
141Atrioventricular block (HP:0001678)1.92132304
142Generalized tonic-clonic seizures (HP:0002069)1.91982434
143Depressed nasal tip (HP:0000437)1.91639339
144Disinhibition (HP:0000734)1.91048108
145Slow saccadic eye movements (HP:0000514)1.90039780
146Scanning speech (HP:0002168)1.90017214
147Bladder neoplasm (HP:0009725)1.89752633
148Bladder carcinoma (HP:0002862)1.89752633
149Right ventricular cardiomyopathy (HP:0011663)1.88845864
150Resting tremor (HP:0002322)1.88038602
151Hepatocellular carcinoma (HP:0001402)1.87872854
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87737752
153Dicarboxylic aciduria (HP:0003215)1.87737752
154Delayed CNS myelination (HP:0002188)1.87476102
155Irritability (HP:0000737)1.86066753
156Sensorimotor neuropathy (HP:0007141)1.85816271
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.85584576
158Areflexia of lower limbs (HP:0002522)1.84472249
159Asymmetric septal hypertrophy (HP:0001670)1.84169780
160Thickened helices (HP:0000391)1.84014226
161Neonatal onset (HP:0003623)1.83781833
162Megalencephaly (HP:0001355)1.83041400
163Optic nerve hypoplasia (HP:0000609)1.82722570
164Malnutrition (HP:0004395)1.82554157
165Colon cancer (HP:0003003)1.81210369
166Reticulocytosis (HP:0001923)1.80287603
167Acute myeloid leukemia (HP:0004808)1.80182040
168Dysdiadochokinesis (HP:0002075)1.80011759
169Poikilocytosis (HP:0004447)1.79815305
170Embryonal neoplasm (HP:0002898)1.79306495
171Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78354041
172Myocardial infarction (HP:0001658)1.78148495
173Truncal obesity (HP:0001956)1.77543425
174Polycythemia (HP:0001901)1.77212677
175Abnormality of the salivary glands (HP:0010286)1.76296981
176Joint hemorrhage (HP:0005261)1.76017556
177Hyperkalemia (HP:0002153)1.75941549
178Acute hepatic failure (HP:0006554)1.75298030
179Uterine neoplasm (HP:0010784)1.74389475
180Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74102098
181Muscle stiffness (HP:0003552)1.73061991
182Heart block (HP:0012722)1.72667343
183Insulin resistance (HP:0000855)1.72412140
184Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71716920
185Abnormality of saccadic eye movements (HP:0000570)1.70191864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.28957697
2STK242.96411075
3MKNK22.78938143
4CDK192.78896308
5TRIB32.75243313
6LATS12.59754504
7MAP3K92.37344376
8PDK32.36699928
9PDK42.36699928
10MAP2K42.32332777
11INSRR2.31828854
12BRD42.22752649
13BCKDK2.13175306
14PKN22.12669434
15KSR22.11581746
16MKNK12.07037510
17CDC72.04096093
18TAOK31.95986714
19PINK11.92307931
20OBSCN1.80148136
21CASK1.77783785
22MAP3K21.73909362
23NLK1.73531385
24MAP3K41.72113605
25ICK1.71850797
26PRKD31.67029241
27TTK1.66845888
28MAP3K61.66574053
29NEK11.62487889
30NTRK31.55771395
31YES11.55507585
32SIK11.54376520
33STK381.52252551
34RET1.51961153
35TTN1.49519509
36RIPK11.47238649
37LATS21.40844893
38FGFR41.39545536
39TYRO31.39515149
40PAK61.37533216
41RPS6KA41.37266272
42OXSR11.32648210
43PHKG11.31313575
44PHKG21.31313575
45PDGFRA1.29380442
46BLK1.24172871
47CAMK1G1.23956978
48DYRK31.21920212
49MAP3K71.19757383
50ERBB41.15942986
51UHMK11.12698702
52PRKAA11.12301338
53TAOK11.09939856
54CDK121.09650546
55CAMK1D1.09288963
56DAPK21.07303793
57PTK61.06717161
58FRK1.04590828
59EPHA41.02098188
60PASK1.01482504
61WNK41.00637690
62LMTK20.99945346
63MAP3K10.97377347
64PRKAA20.97077177
65FGFR20.96575762
66WNK10.94126978
67PDK20.93823868
68SGK30.93241485
69PNCK0.91633855
70DMPK0.91308802
71TAF10.91097029
72PDPK10.90432944
73PDK10.88969145
74PLK30.85363536
75PAK30.85074833
76JAK20.84795446
77KSR10.84319398
78MAPK110.84116842
79CAMK40.83635148
80PIM10.83206254
81STK110.80935047
82PRPF4B0.80274235
83ACVR1B0.76327635
84SRPK10.75768263
85DYRK1A0.75471311
86HIPK20.73639047
87DYRK1B0.73131392
88ERN10.71021890
89PRKCH0.70910692
90MAP3K100.70803139
91MTOR0.69739018
92CAMKK10.69701559
93PLK20.69668129
94PTK20.69582337
95MAP3K130.67462293
96MARK10.67034732
97FGFR10.66367268
98MAP3K50.66328275
99NTRK10.66285624
100ZAK0.66186831
101CDK60.65641765
102EEF2K0.65472159
103CAMK10.64246701
104PRKD10.62395743
105STK390.62275607
106TSSK60.60992315
107ALK0.60724809
108FGR0.58089305
109CSNK1E0.57585971
110MAPK120.57042999
111STK30.55576965
112AKT30.54620263
113CDK30.54541026
114SGK20.54046402
115MAP2K30.54034286
116MELK0.54006100
117RPS6KA30.53857670
118SGK4940.53570606
119SGK2230.53570606
120PRKG10.52991889
121RPS6KB10.52889684
122EGFR0.52611220
123PRKACG0.52205515
124MET0.50877956
125SGK10.50724787
126SCYL20.50712401
127FLT30.49854192
128FER0.49691159
129FGFR30.48558251
130RPS6KB20.48090287
131PDGFRB0.47852949
132CDC42BPA0.46809039
133MAPK150.46709913
134DDR20.46001108
135CAMK2G0.45494534
136NTRK20.45358430
137PIK3CG0.44519055
138EPHB10.44065507
139STK40.43093684
140ATM0.41857147
141CDK50.41504760
142STK38L0.41414137
143MAPK100.41079443
144MAPK70.40862035
145MOS0.40714012
146MARK20.39863652
147CSNK1D0.39515223
148GSK3B0.38722253
149MARK30.38659041
150RIPK40.38471636
151CHEK10.36695532
152NEK60.35519976

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.57745651
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45814211
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.17024836
4Arginine biosynthesis_Homo sapiens_hsa002203.01160662
5Fatty acid degradation_Homo sapiens_hsa000712.39900493
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37066391
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34584794
8Long-term depression_Homo sapiens_hsa047302.30272641
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24932981
10Nicotine addiction_Homo sapiens_hsa050332.23284340
11Propanoate metabolism_Homo sapiens_hsa006402.20090924
12Butanoate metabolism_Homo sapiens_hsa006502.14505195
13Tryptophan metabolism_Homo sapiens_hsa003802.12554719
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04860664
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00979779
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.98668254
17mRNA surveillance pathway_Homo sapiens_hsa030151.93742462
18Fatty acid metabolism_Homo sapiens_hsa012121.93166822
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85980239
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77175185
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74319035
22PPAR signaling pathway_Homo sapiens_hsa033201.71854767
23Bile secretion_Homo sapiens_hsa049761.69989329
24FoxO signaling pathway_Homo sapiens_hsa040681.68803272
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67329280
26Pyruvate metabolism_Homo sapiens_hsa006201.52409520
27Oocyte meiosis_Homo sapiens_hsa041141.52042010
28Adherens junction_Homo sapiens_hsa045201.49827720
29Complement and coagulation cascades_Homo sapiens_hsa046101.44532658
30Endometrial cancer_Homo sapiens_hsa052131.41818140
31Carbon metabolism_Homo sapiens_hsa012001.36802139
32Peroxisome_Homo sapiens_hsa041461.33976016
33Fatty acid biosynthesis_Homo sapiens_hsa000611.31633362
34Cell cycle_Homo sapiens_hsa041101.28119975
35Regulation of autophagy_Homo sapiens_hsa041401.26982578
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25215883
37Sulfur metabolism_Homo sapiens_hsa009201.24307584
38Tight junction_Homo sapiens_hsa045301.24097998
39Biosynthesis of amino acids_Homo sapiens_hsa012301.23824993
40Selenocompound metabolism_Homo sapiens_hsa004501.22486608
41beta-Alanine metabolism_Homo sapiens_hsa004101.22380086
42Fat digestion and absorption_Homo sapiens_hsa049751.19767831
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18499897
44Starch and sucrose metabolism_Homo sapiens_hsa005001.17492239
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16134202
46Thyroid cancer_Homo sapiens_hsa052161.15140882
47Renal cell carcinoma_Homo sapiens_hsa052111.14955871
48ErbB signaling pathway_Homo sapiens_hsa040121.14664819
49ABC transporters_Homo sapiens_hsa020101.11859804
50RNA degradation_Homo sapiens_hsa030181.11060895
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10968714
52Lysine degradation_Homo sapiens_hsa003101.10297844
53Prostate cancer_Homo sapiens_hsa052151.10041484
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08978838
55Caffeine metabolism_Homo sapiens_hsa002321.08643391
56Taste transduction_Homo sapiens_hsa047421.05233403
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04246811
58Phenylalanine metabolism_Homo sapiens_hsa003601.01962412
59cAMP signaling pathway_Homo sapiens_hsa040241.00338625
60Inositol phosphate metabolism_Homo sapiens_hsa005621.00218399
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99925046
62Glucagon signaling pathway_Homo sapiens_hsa049220.99362723
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98617906
64Morphine addiction_Homo sapiens_hsa050320.96077041
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.95886070
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95852396
67B cell receptor signaling pathway_Homo sapiens_hsa046620.95232363
68T cell receptor signaling pathway_Homo sapiens_hsa046600.95198592
69Type II diabetes mellitus_Homo sapiens_hsa049300.94551664
70Histidine metabolism_Homo sapiens_hsa003400.92923918
71Chemical carcinogenesis_Homo sapiens_hsa052040.91960421
72Colorectal cancer_Homo sapiens_hsa052100.91664809
73Glycerolipid metabolism_Homo sapiens_hsa005610.90255278
74Insulin resistance_Homo sapiens_hsa049310.89551011
75MicroRNAs in cancer_Homo sapiens_hsa052060.88398232
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87438577
77Prolactin signaling pathway_Homo sapiens_hsa049170.86787015
78* MAPK signaling pathway_Homo sapiens_hsa040100.86074275
79Cholinergic synapse_Homo sapiens_hsa047250.85530117
80Wnt signaling pathway_Homo sapiens_hsa043100.85211724
81Calcium signaling pathway_Homo sapiens_hsa040200.85043962
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84909266
83Serotonergic synapse_Homo sapiens_hsa047260.84653066
84RNA transport_Homo sapiens_hsa030130.84089486
85Choline metabolism in cancer_Homo sapiens_hsa052310.83289026
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83288569
87Non-small cell lung cancer_Homo sapiens_hsa052230.83100943
88Insulin secretion_Homo sapiens_hsa049110.80853008
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80825417
90Tyrosine metabolism_Homo sapiens_hsa003500.80368264
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79072610
92Gap junction_Homo sapiens_hsa045400.78832888
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.74724911
94Retinol metabolism_Homo sapiens_hsa008300.74463248
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.72770941
96Non-homologous end-joining_Homo sapiens_hsa034500.72683523
97Spliceosome_Homo sapiens_hsa030400.71953251
98Ras signaling pathway_Homo sapiens_hsa040140.71349140
99AMPK signaling pathway_Homo sapiens_hsa041520.70992914
100Fatty acid elongation_Homo sapiens_hsa000620.70403455
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69884723
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.69684926
103Dorso-ventral axis formation_Homo sapiens_hsa043200.68965149
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67810219
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.67708921
106Insulin signaling pathway_Homo sapiens_hsa049100.66704252
107Arginine and proline metabolism_Homo sapiens_hsa003300.66684170
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.66550071
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.66310705
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64452742
111mTOR signaling pathway_Homo sapiens_hsa041500.63476355
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63247874
113Rap1 signaling pathway_Homo sapiens_hsa040150.62300837
114Basal transcription factors_Homo sapiens_hsa030220.61877385
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.59224971
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58970603
117Vitamin B6 metabolism_Homo sapiens_hsa007500.58184738
118VEGF signaling pathway_Homo sapiens_hsa043700.57355194
119Circadian rhythm_Homo sapiens_hsa047100.57105477
120Long-term potentiation_Homo sapiens_hsa047200.55747622
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55573117
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55006685
123Glioma_Homo sapiens_hsa052140.54059007
124Acute myeloid leukemia_Homo sapiens_hsa052210.52986565
125GABAergic synapse_Homo sapiens_hsa047270.52907871
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52310264
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.51263442
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49927550
129Folate biosynthesis_Homo sapiens_hsa007900.48324617
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47337876
131Staphylococcus aureus infection_Homo sapiens_hsa051500.44924762
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44327690
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.43133301
134Cardiac muscle contraction_Homo sapiens_hsa042600.39182853
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.38953574
136Amphetamine addiction_Homo sapiens_hsa050310.38416381
137Renin secretion_Homo sapiens_hsa049240.38285348
138Dilated cardiomyopathy_Homo sapiens_hsa054140.36092716
139Prion diseases_Homo sapiens_hsa050200.35541035
140Thyroid hormone synthesis_Homo sapiens_hsa049180.34999846
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32625129
142Pentose phosphate pathway_Homo sapiens_hsa000300.32297481
143Gastric acid secretion_Homo sapiens_hsa049710.32240572
144Fructose and mannose metabolism_Homo sapiens_hsa000510.31961735
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.31522130
146Glutamatergic synapse_Homo sapiens_hsa047240.31489886
147Estrogen signaling pathway_Homo sapiens_hsa049150.31435260
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31066543
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29908563
150Dopaminergic synapse_Homo sapiens_hsa047280.29520295
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28993534
152Pancreatic secretion_Homo sapiens_hsa049720.28859384
153Oxytocin signaling pathway_Homo sapiens_hsa049210.28594874
154Salivary secretion_Homo sapiens_hsa049700.27102796
155Circadian entrainment_Homo sapiens_hsa047130.26997647
156GnRH signaling pathway_Homo sapiens_hsa049120.26178510

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »