PPIL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.34561427
2telomere maintenance via semi-conservative replication (GO:0032201)5.12157733
3DNA strand elongation (GO:0022616)5.09241796
4ribosomal small subunit assembly (GO:0000028)4.93641564
5DNA replication initiation (GO:0006270)4.87529832
6nuclear pore organization (GO:0006999)4.71249087
7DNA unwinding involved in DNA replication (GO:0006268)4.65566580
8maturation of SSU-rRNA (GO:0030490)4.54205713
9telomere maintenance via recombination (GO:0000722)4.53416071
10nucleobase biosynthetic process (GO:0046112)4.48303269
11DNA replication checkpoint (GO:0000076)4.46192828
12DNA deamination (GO:0045006)4.45680003
13establishment of viral latency (GO:0019043)4.40593632
14formation of translation preinitiation complex (GO:0001731)4.37785772
15mitotic recombination (GO:0006312)4.27225857
16purine nucleobase biosynthetic process (GO:0009113)4.25962968
17mitotic metaphase plate congression (GO:0007080)4.12171704
18telomere maintenance via telomere lengthening (GO:0010833)4.09939029
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07074894
20viral transcription (GO:0019083)4.02327978
21protein localization to kinetochore (GO:0034501)3.99174001
22translational termination (GO:0006415)3.96269855
23CENP-A containing nucleosome assembly (GO:0034080)3.95850501
24nucleotide-excision repair, DNA gap filling (GO:0006297)3.93931793
25ribosomal small subunit biogenesis (GO:0042274)3.88842609
26chromatin remodeling at centromere (GO:0031055)3.86918766
27ribosome biogenesis (GO:0042254)3.85300164
28ribosomal large subunit biogenesis (GO:0042273)3.84502572
29ribonucleoprotein complex biogenesis (GO:0022613)3.81740715
30translational elongation (GO:0006414)3.68767944
31DNA replication-dependent nucleosome organization (GO:0034723)3.67439174
32DNA replication-dependent nucleosome assembly (GO:0006335)3.67439174
33spliceosomal snRNP assembly (GO:0000387)3.67173737
34IMP biosynthetic process (GO:0006188)3.66882448
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65234853
36proteasome assembly (GO:0043248)3.64198567
37translational initiation (GO:0006413)3.60837881
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60736393
39transcription-coupled nucleotide-excision repair (GO:0006283)3.58057302
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57296995
41DNA replication-independent nucleosome organization (GO:0034724)3.55944470
42DNA replication-independent nucleosome assembly (GO:0006336)3.55944470
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54879755
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53308209
45metaphase plate congression (GO:0051310)3.53161846
46ribosome assembly (GO:0042255)3.51454609
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.50184313
48rRNA processing (GO:0006364)3.49867551
49mitotic nuclear envelope disassembly (GO:0007077)3.49754538
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49321458
51mitotic chromosome condensation (GO:0007076)3.48587429
52kinetochore organization (GO:0051383)3.47149074
53DNA ligation (GO:0006266)3.44685278
54sister chromatid segregation (GO:0000819)3.44523108
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.44344221
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44344221
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44317988
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40905807
59rRNA metabolic process (GO:0016072)3.38388138
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37667242
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37431496
62ATP synthesis coupled proton transport (GO:0015986)3.37431496
63protein localization to chromosome, centromeric region (GO:0071459)3.36605722
64spindle checkpoint (GO:0031577)3.35467279
65pseudouridine synthesis (GO:0001522)3.35366166
66rRNA modification (GO:0000154)3.34738419
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33251363
68negative regulation of ligase activity (GO:0051352)3.33251363
69cotranslational protein targeting to membrane (GO:0006613)3.32224644
70kinetochore assembly (GO:0051382)3.31345995
71protein targeting to ER (GO:0045047)3.29849650
72folic acid-containing compound biosynthetic process (GO:0009396)3.28694154
73chaperone-mediated protein transport (GO:0072321)3.26923014
74establishment of integrated proviral latency (GO:0075713)3.26559185
75G1/S transition of mitotic cell cycle (GO:0000082)3.26124149
76cell cycle G1/S phase transition (GO:0044843)3.26124149
77DNA damage response, detection of DNA damage (GO:0042769)3.26052960
78establishment of chromosome localization (GO:0051303)3.22905789
79histone exchange (GO:0043486)3.21835844
80nuclear pore complex assembly (GO:0051292)3.20962779
81mitotic spindle checkpoint (GO:0071174)3.20671531
82viral mRNA export from host cell nucleus (GO:0046784)3.20666206
83negative regulation of chromosome segregation (GO:0051985)3.20191790
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20103950
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20103950
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20103950
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.20103950
88negative regulation of sister chromatid segregation (GO:0033046)3.20103950
89cellular protein complex disassembly (GO:0043624)3.19055416
90IMP metabolic process (GO:0046040)3.18246799
91nuclear envelope disassembly (GO:0051081)3.18082023
92membrane disassembly (GO:0030397)3.18082023
93regulation of mitochondrial translation (GO:0070129)3.16635289
94spliceosomal complex assembly (GO:0000245)3.16487545
95attachment of spindle microtubules to kinetochore (GO:0008608)3.16121248
96regulation of double-strand break repair via homologous recombination (GO:0010569)3.15464004
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14157400
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.13671374
99termination of RNA polymerase III transcription (GO:0006386)3.13671374
100regulation of chromosome segregation (GO:0051983)3.12870213
101translation (GO:0006412)3.12294338
102viral life cycle (GO:0019058)3.12217592
103telomere organization (GO:0032200)3.12134146
104establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11440671
105protein localization to endoplasmic reticulum (GO:0070972)3.11224328
106telomere maintenance (GO:0000723)3.11160998
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10595880
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10595880
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10037437
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10037437
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10037437
112cullin deneddylation (GO:0010388)3.08211477
1137-methylguanosine mRNA capping (GO:0006370)3.07660408
114signal transduction involved in DNA damage checkpoint (GO:0072422)3.07409444
115signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07409444
116L-serine metabolic process (GO:0006563)3.07127548
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05722523
118mitotic spindle assembly checkpoint (GO:0007094)3.05184712
119regulation of nuclear cell cycle DNA replication (GO:0033262)3.05117312
120mitotic sister chromatid segregation (GO:0000070)3.04923445
121signal transduction involved in cell cycle checkpoint (GO:0072395)3.04313372
122DNA catabolic process, exonucleolytic (GO:0000738)3.02940141
123spindle assembly checkpoint (GO:0071173)3.02611914
124RNA capping (GO:0036260)3.02124593
1257-methylguanosine RNA capping (GO:0009452)3.02124593
126termination of RNA polymerase I transcription (GO:0006363)2.99129708
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97592053
128tRNA aminoacylation for protein translation (GO:0006418)2.97378945
129cellular component biogenesis (GO:0044085)2.97351399
130amino acid activation (GO:0043038)2.94040606
131tRNA aminoacylation (GO:0043039)2.94040606
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90716910
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90716910
134non-recombinational repair (GO:0000726)2.89210388
135double-strand break repair via nonhomologous end joining (GO:0006303)2.89210388
136protein deneddylation (GO:0000338)2.88017263
137positive regulation of ligase activity (GO:0051351)2.87527714
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.87442358
139regulation of sister chromatid segregation (GO:0033045)2.83212357
140regulation of mitotic sister chromatid separation (GO:0010965)2.83212357
141regulation of mitotic sister chromatid segregation (GO:0033047)2.83212357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51643119
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.41972943
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87569015
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58079536
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56867423
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.53985866
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.24002658
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14054579
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.10091845
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09727790
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05512878
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00793876
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.00485769
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93808137
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79484779
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77074466
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47280727
18XRN2_22483619_ChIP-Seq_HELA_Human2.42116657
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40082247
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38330370
21* VDR_23849224_ChIP-Seq_CD4+_Human2.29307396
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21896178
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11932752
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11783410
25FOXP3_21729870_ChIP-Seq_TREG_Human2.07839468
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06094510
27DCP1A_22483619_ChIP-Seq_HELA_Human2.05788986
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04448974
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99877237
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98531462
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97606801
32* GABP_19822575_ChIP-Seq_HepG2_Human1.95746864
33AR_21909140_ChIP-Seq_LNCAP_Human1.95143723
34TTF2_22483619_ChIP-Seq_HELA_Human1.89944694
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.86351744
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82679977
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82604925
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.82255044
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80389603
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76628245
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74092923
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73260310
43CIITA_25753668_ChIP-Seq_RAJI_Human1.68349659
44ELK1_19687146_ChIP-ChIP_HELA_Human1.64065814
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63131204
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61355992
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60793605
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.60376715
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60150155
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54649989
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50236320
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49864275
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43619282
54* MYC_22102868_ChIP-Seq_BL_Human1.42079744
55KDM5A_27292631_Chip-Seq_BREAST_Human1.38986896
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36296245
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.36204965
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35818046
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32174825
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.30301779
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30187955
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28090673
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26317000
64* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23746989
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23040348
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18305033
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17419164
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15064453
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.14694541
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12604844
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12153824
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12009094
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.11181811
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10114658
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.09835338
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.09609230
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08840368
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06506746
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.05925117
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04344783
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03376882
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02686436
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02420863
84MYC_18940864_ChIP-ChIP_HL60_Human1.02008880
85TFEB_21752829_ChIP-Seq_HELA_Human1.01571933
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00661870
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95192862
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93766549
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91955339
90VDR_21846776_ChIP-Seq_THP-1_Human0.91782967
91* ELK1_22589737_ChIP-Seq_MCF10A_Human0.91215942
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90712848
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90600813
94* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89781527
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89478752
96SPI1_23547873_ChIP-Seq_NB4_Human0.89213455
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88338879
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87797611
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86923536
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86727606
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85228293
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84866008
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82959312
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82416947
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82202770
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81933209
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79994310
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79877258
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79344049
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.78534344
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77580319
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77338052
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77222436
114EWS_26573619_Chip-Seq_HEK293_Human0.77096876
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76150391
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75523214
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73033928
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.69756700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.83932742
2MP0010094_abnormal_chromosome_stability5.03855400
3MP0004957_abnormal_blastocyst_morpholog4.79947173
4MP0003111_abnormal_nucleus_morphology4.79281835
5MP0008057_abnormal_DNA_replication4.37287283
6MP0003077_abnormal_cell_cycle4.25657868
7MP0008058_abnormal_DNA_repair3.88721267
8MP0008007_abnormal_cellular_replicative2.94958266
9MP0008932_abnormal_embryonic_tissue2.91942335
10MP0002396_abnormal_hematopoietic_system2.56842824
11MP0001730_embryonic_growth_arrest2.35599608
12MP0003123_paternal_imprinting2.29050795
13MP0003786_premature_aging2.21588658
14MP0000350_abnormal_cell_proliferation2.20101278
15MP0009697_abnormal_copulation2.03654160
16MP0008877_abnormal_DNA_methylation1.99231628
17MP0010352_gastrointestinal_tract_polyps1.90599640
18MP0000490_abnormal_crypts_of1.81698535
19MP0003806_abnormal_nucleotide_metabolis1.72656000
20MP0003136_yellow_coat_color1.71836664
21MP0001697_abnormal_embryo_size1.65712662
22MP0003718_maternal_effect1.64024654
23MP0001672_abnormal_embryogenesis/_devel1.63782393
24MP0005380_embryogenesis_phenotype1.63782393
25MP0005499_abnormal_olfactory_system1.60006695
26MP0005394_taste/olfaction_phenotype1.60006695
27MP0000313_abnormal_cell_death1.58634984
28MP0006292_abnormal_olfactory_placode1.57985567
29MP0002080_prenatal_lethality1.57530983
30MP0002019_abnormal_tumor_incidence1.52922855
31MP0010307_abnormal_tumor_latency1.49678276
32MP0009333_abnormal_splenocyte_physiolog1.48380278
33MP0000372_irregular_coat_pigmentation1.46212701
34MP0003984_embryonic_growth_retardation1.45553809
35MP0002697_abnormal_eye_size1.43050194
36MP0000049_abnormal_middle_ear1.40948675
37MP0002085_abnormal_embryonic_tissue1.40791511
38MP0002088_abnormal_embryonic_growth/wei1.40663752
39MP0003763_abnormal_thymus_physiology1.38928366
40MP0003567_abnormal_fetal_cardiomyocyte1.36718887
41MP0004808_abnormal_hematopoietic_stem1.32867168
42MP0002233_abnormal_nose_morphology1.27521736
43MP0010030_abnormal_orbit_morphology1.26700012
44MP0003315_abnormal_perineum_morphology1.23296623
45MP0004133_heterotaxia1.22206341
46MP0002084_abnormal_developmental_patter1.19482946
47MP0002086_abnormal_extraembryonic_tissu1.17768978
48MP0006072_abnormal_retinal_apoptosis1.17674796
49MP0003186_abnormal_redox_activity1.17512453
50MP0002210_abnormal_sex_determination1.16550333
51MP0002234_abnormal_pharynx_morphology1.16263335
52MP0002398_abnormal_bone_marrow1.15642268
53MP0000703_abnormal_thymus_morphology1.14965984
54MP0009379_abnormal_foot_pigmentation1.13286844
55MP0001545_abnormal_hematopoietic_system1.12935547
56MP0005397_hematopoietic_system_phenotyp1.12935547
57MP0004197_abnormal_fetal_growth/weight/1.11545932
58MP0001293_anophthalmia1.11051273
59MP0003890_abnormal_embryonic-extraembry1.10845356
60MP0003121_genomic_imprinting1.10336953
61MP0002722_abnormal_immune_system1.10111784
62MP0002160_abnormal_reproductive_system1.09111169
63MP0006054_spinal_hemorrhage1.08988791
64MP0002132_abnormal_respiratory_system1.08397359
65MP0001299_abnormal_eye_distance/1.05290418
66MP0006036_abnormal_mitochondrial_physio1.05279507
67MP0000689_abnormal_spleen_morphology1.04654708
68MP0001145_abnormal_male_reproductive1.03882770
69MP0000358_abnormal_cell_content/0.97806983
70MP0005408_hypopigmentation0.97658418
71MP0001346_abnormal_lacrimal_gland0.96497758
72MP0006035_abnormal_mitochondrial_morpho0.94502950
73MP0002429_abnormal_blood_cell0.93081522
74MP0000858_altered_metastatic_potential0.91707270
75MP0003119_abnormal_digestive_system0.89225963
76MP0000647_abnormal_sebaceous_gland0.87265293
77MP0000537_abnormal_urethra_morphology0.86849435
78MP0003861_abnormal_nervous_system0.85593409
79MP0000653_abnormal_sex_gland0.84261867
80MP0005187_abnormal_penis_morphology0.84024988
81MP0005389_reproductive_system_phenotype0.83574390
82MP0000749_muscle_degeneration0.82796633
83MP0001853_heart_inflammation0.82600626
84MP0001929_abnormal_gametogenesis0.82055018
85MP0005075_abnormal_melanosome_morpholog0.82011493
86MP0003221_abnormal_cardiomyocyte_apopto0.81689630
87MP0001188_hyperpigmentation0.80777024
88MP0002163_abnormal_gland_morphology0.80004728
89MP0002092_abnormal_eye_morphology0.77830633
90MP0001119_abnormal_female_reproductive0.77637184
91MP0000716_abnormal_immune_system0.77338664
92MP0003698_abnormal_male_reproductive0.77304350
93MP0003755_abnormal_palate_morphology0.76636049
94MP0005384_cellular_phenotype0.75633575
95MP0001849_ear_inflammation0.74870913
96MP0005391_vision/eye_phenotype0.73986539
97MP0003941_abnormal_skin_development0.73648732
98MP0009053_abnormal_anal_canal0.73056942
99MP0000631_abnormal_neuroendocrine_gland0.71288897
100MP0003385_abnormal_body_wall0.71232802
101MP0001661_extended_life_span0.70171718
102MP0009672_abnormal_birth_weight0.69666629
103MP0002161_abnormal_fertility/fecundity0.69473010
104MP0002111_abnormal_tail_morphology0.69257280
105MP0002090_abnormal_vision0.68045574
106MP0005266_abnormal_metabolism0.67215944
107MP0009703_decreased_birth_body0.66181970
108MP0000762_abnormal_tongue_morphology0.66021629
109MP0002095_abnormal_skin_pigmentation0.65018595
110MP0002102_abnormal_ear_morphology0.64030545
111MP0002938_white_spotting0.63725228
112MP0004233_abnormal_muscle_weight0.63542071
113MP0005621_abnormal_cell_physiology0.63088695
114MP0003942_abnormal_urinary_system0.62915965
115MP0006276_abnormal_autonomic_nervous0.62512725
116MP0000477_abnormal_intestine_morphology0.61725795
117MP0003938_abnormal_ear_development0.60325675
118MP0005253_abnormal_eye_physiology0.59781642
119MP0002420_abnormal_adaptive_immunity0.58506366
120MP0001800_abnormal_humoral_immune0.57355430
121MP0001819_abnormal_immune_cell0.56894134
122MP0004147_increased_porphyrin_level0.56857562
123MP0005671_abnormal_response_to0.56586351
124MP0001835_abnormal_antigen_presentation0.55977602
125MP0001286_abnormal_eye_development0.55010135
126MP0008789_abnormal_olfactory_epithelium0.54052334
127MP0001727_abnormal_embryo_implantation0.52849279
128MP0001919_abnormal_reproductive_system0.52842903
129MP0001529_abnormal_vocalization0.52614781
130MP0001764_abnormal_homeostasis0.50388621
131MP0002452_abnormal_antigen_presenting0.49820378
132MP0005174_abnormal_tail_pigmentation0.49628353
133MP0002751_abnormal_autonomic_nervous0.49119041
134MP0000566_synostosis0.48664100
135MP0003937_abnormal_limbs/digits/tail_de0.48588052
136MP0008995_early_reproductive_senescence0.48283875

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.46213159
2Reticulocytopenia (HP:0001896)4.78574704
3Abnormality of cells of the erythroid lineage (HP:0012130)4.63519137
4Abnormal number of erythroid precursors (HP:0012131)4.43852976
5Breast hypoplasia (HP:0003187)4.29819205
6Colon cancer (HP:0003003)3.87727249
7Oral leukoplakia (HP:0002745)3.84755088
8Chromsome breakage (HP:0040012)3.55679821
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46788617
10Patellar aplasia (HP:0006443)3.45951351
11Aplastic anemia (HP:0001915)3.29768485
12Aplasia/Hypoplasia of the patella (HP:0006498)3.25525057
13Selective tooth agenesis (HP:0001592)3.25389387
14Carpal bone hypoplasia (HP:0001498)3.25351926
15Rough bone trabeculation (HP:0100670)3.21054408
16Cortical dysplasia (HP:0002539)3.19171493
17Cerebral hypomyelination (HP:0006808)3.15386707
18Abnormality of the preputium (HP:0100587)3.11071132
19Macrocytic anemia (HP:0001972)3.07812535
20Acute encephalopathy (HP:0006846)3.06772571
21Abnormal mitochondria in muscle tissue (HP:0008316)3.06698509
22Meckel diverticulum (HP:0002245)3.06140911
23Absent thumb (HP:0009777)2.97170650
24Abnormality of the anterior horn cell (HP:0006802)2.95768137
25Degeneration of anterior horn cells (HP:0002398)2.95768137
26Medulloblastoma (HP:0002885)2.94958002
27Abnormality of the ileum (HP:0001549)2.93358758
28Pallor (HP:0000980)2.87892633
29Abnormality of chromosome stability (HP:0003220)2.81993924
30Ependymoma (HP:0002888)2.75677128
3111 pairs of ribs (HP:0000878)2.75077209
32Agnosia (HP:0010524)2.73370321
33Microretrognathia (HP:0000308)2.72938957
34Premature graying of hair (HP:0002216)2.68358866
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.62933834
36Multiple enchondromatosis (HP:0005701)2.60852971
37Bone marrow hypocellularity (HP:0005528)2.60426283
38Absent radius (HP:0003974)2.57557765
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55866932
40Neoplasm of the pancreas (HP:0002894)2.55582187
41Cellular immunodeficiency (HP:0005374)2.53289369
42Myelodysplasia (HP:0002863)2.50947816
43Abnormal number of incisors (HP:0011064)2.49573889
44Abnormal lung lobation (HP:0002101)2.47478176
45Progressive macrocephaly (HP:0004481)2.47292338
46Small intestinal stenosis (HP:0012848)2.46918337
47Duodenal stenosis (HP:0100867)2.46918337
48Cholecystitis (HP:0001082)2.45439498
49Abnormal gallbladder physiology (HP:0012438)2.45439498
50Hypoplastic pelvis (HP:0008839)2.42539361
51Lipid accumulation in hepatocytes (HP:0006561)2.41961832
52Trismus (HP:0000211)2.39829464
53Absent forearm bone (HP:0003953)2.38646237
54Aplasia involving forearm bones (HP:0009822)2.38646237
55Increased nuchal translucency (HP:0010880)2.35547699
56Impulsivity (HP:0100710)2.34874825
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33354059
58Shoulder girdle muscle weakness (HP:0003547)2.31480728
59Cerebral edema (HP:0002181)2.28658147
60Thrombocytosis (HP:0001894)2.28147516
61Increased serum lactate (HP:0002151)2.27802189
62Hyperglycinemia (HP:0002154)2.26768090
63Duplicated collecting system (HP:0000081)2.26657507
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26242760
65Horseshoe kidney (HP:0000085)2.23974228
66Tracheoesophageal fistula (HP:0002575)2.23921551
67Abnormal trabecular bone morphology (HP:0100671)2.23652339
68Facial cleft (HP:0002006)2.19467314
69Abnormality of the labia minora (HP:0012880)2.18884204
70Pancytopenia (HP:0001876)2.18557572
71Cleft eyelid (HP:0000625)2.17956167
72Nephroblastoma (Wilms tumor) (HP:0002667)2.17214167
73Sloping forehead (HP:0000340)2.16348511
74IgM deficiency (HP:0002850)2.14977556
75Triphalangeal thumb (HP:0001199)2.13378307
76Abnormality of methionine metabolism (HP:0010901)2.12936510
77Increased serum pyruvate (HP:0003542)2.10025427
78Abnormality of glycolysis (HP:0004366)2.10025427
79Atresia of the external auditory canal (HP:0000413)2.07985407
80Lymphoma (HP:0002665)2.07898953
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07434547
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07434547
83Rhabdomyosarcoma (HP:0002859)2.07371410
84Secondary amenorrhea (HP:0000869)2.06488257
85Lactic acidosis (HP:0003128)2.05041298
86Neoplasm of the colon (HP:0100273)2.01018946
87Embryonal renal neoplasm (HP:0011794)2.00596073
88Hepatocellular necrosis (HP:0001404)2.00573039
89Abnormality of the carotid arteries (HP:0005344)2.00555852
90Squamous cell carcinoma (HP:0002860)1.99727055
91Type I transferrin isoform profile (HP:0003642)1.99086624
92Abnormality of the duodenum (HP:0002246)1.98571939
93Increased CSF lactate (HP:0002490)1.98504290
94Renal Fanconi syndrome (HP:0001994)1.98076929
95Basal cell carcinoma (HP:0002671)1.97659552
96Reduced antithrombin III activity (HP:0001976)1.97380639
97Volvulus (HP:0002580)1.97157956
98Supernumerary spleens (HP:0009799)1.96624069
99Abnormality of the renal collecting system (HP:0004742)1.95184001
100Ectopic kidney (HP:0000086)1.93514585
101Exercise intolerance (HP:0003546)1.93357509
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92893808
103Abnormal protein glycosylation (HP:0012346)1.92159615
104Abnormal glycosylation (HP:0012345)1.92159615
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92159615
106Abnormal protein N-linked glycosylation (HP:0012347)1.92159615
107Premature ovarian failure (HP:0008209)1.91889725
108Esophageal atresia (HP:0002032)1.90316091
109Abnormality of serum amino acid levels (HP:0003112)1.90039154
110Asplenia (HP:0001746)1.89999989
111Amniotic constriction ring (HP:0009775)1.89791784
112Abnormality of placental membranes (HP:0011409)1.89791784
113Microvesicular hepatic steatosis (HP:0001414)1.89297583
114Hypoglycemic coma (HP:0001325)1.88755067
115Mitochondrial inheritance (HP:0001427)1.88377363
116Gout (HP:0001997)1.87349924
117Type 2 muscle fiber atrophy (HP:0003554)1.87038194
118Slender long bone (HP:0003100)1.86618776
119Optic nerve coloboma (HP:0000588)1.85467497
120Increased hepatocellular lipid droplets (HP:0006565)1.85120353
121Abnormality of alanine metabolism (HP:0010916)1.84114200
122Hyperalaninemia (HP:0003348)1.84114200
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84114200
124Septo-optic dysplasia (HP:0100842)1.83944898
125Abnormality of pyrimidine metabolism (HP:0004353)1.83024126
126Short thumb (HP:0009778)1.82597868
127Hypoplasia of the radius (HP:0002984)1.81839448
128Muscle fiber atrophy (HP:0100295)1.81394739
129Postnatal microcephaly (HP:0005484)1.81264617
1303-Methylglutaconic aciduria (HP:0003535)1.80882253
131Glossoptosis (HP:0000162)1.80833179
132Hepatic necrosis (HP:0002605)1.80633368
133Megaloblastic anemia (HP:0001889)1.80586046
134CNS hypomyelination (HP:0003429)1.77976529
135Abnormality of DNA repair (HP:0003254)1.77558931
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.77392142
137Acute necrotizing encephalopathy (HP:0006965)1.77266865
138Increased intramyocellular lipid droplets (HP:0012240)1.77183117
139Absent septum pellucidum (HP:0001331)1.76881977
140Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76485211
141Spastic diplegia (HP:0001264)1.76073454
142Leukodystrophy (HP:0002415)1.74264292
143Sparse eyelashes (HP:0000653)1.68409321
144Respiratory difficulties (HP:0002880)1.67384445
145Abnormality of sulfur amino acid metabolism (HP:0004339)1.66931878
146Hypoplasia of the pons (HP:0012110)1.65839980
147Proximal placement of thumb (HP:0009623)1.65538779
148Stenosis of the external auditory canal (HP:0000402)1.61488134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.37955329
2WEE14.59748843
3VRK24.53110051
4CDC73.75391385
5EIF2AK13.48144711
6SRPK12.82154055
7STK162.78739283
8TSSK62.66809221
9NME22.61191395
10TAF12.42156657
11EIF2AK32.28591547
12NEK12.23485030
13PLK42.19819747
14NEK22.19078925
15BRSK22.16710629
16TESK22.09621962
17VRK12.08086134
18TTK2.06957410
19ACVR1B1.97915748
20PLK11.96135045
21MKNK11.72176022
22CDK71.69726810
23CCNB11.68242899
24ATR1.68091885
25DYRK31.65236003
26TLK11.64776908
27AURKB1.60730263
28PLK31.57139663
29TRIM281.56604566
30PASK1.56517401
31RPS6KB21.52066370
32BRSK11.47329541
33AURKA1.30483839
34CHEK21.26764496
35PIM21.24268660
36MKNK21.21763284
37RPS6KA41.21271697
38NUAK11.19937530
39ZAK1.15706974
40MUSK1.15670167
41CDK41.15187173
42TGFBR11.14932072
43MAP3K81.09420103
44CHEK11.08909510
45CDK81.04200707
46STK41.02372587
47EPHA21.01623569
48PAK40.98482346
49KDR0.97733007
50SCYL20.96307168
51WNK30.95854167
52PDK20.92829210
53EIF2AK20.89698863
54STK100.88379131
55MAP4K10.88273583
56BCR0.87594693
57ERBB40.83328497
58BCKDK0.82584506
59PIM10.82255925
60TESK10.78728209
61NME10.77685645
62CSNK2A20.76610197
63CSNK2A10.74851905
64CDK20.73750902
65CSNK1G10.73380212
66PLK20.72526366
67ATM0.72203584
68BRAF0.72169721
69MAP3K120.71979002
70CSNK1G20.67259467
71TNIK0.66473963
72PRKCI0.66320268
73MAP3K110.66233444
74PAK10.65233240
75LRRK20.64837698
76EEF2K0.64418176
77CSNK1A1L0.64120189
78CLK10.62861992
79STK38L0.62121897
80MAP2K70.59021610
81MAP3K100.56264126
82TAOK20.55532540
83CDK10.55105686
84DYRK20.54827178
85BMPR1B0.53443562
86STK30.53253122
87CDK190.52610186
88PBK0.51704707
89MELK0.50594645
90ALK0.49994996
91CDK120.48045177
92RPS6KA50.47344960
93FLT30.46590361
94CDK140.45029211
95BTK0.44938631
96ERBB30.43211588
97MAP2K30.42197225
98MST40.42191175
99PNCK0.41774509
100ILK0.41419600
101CDK180.41284605
102LATS10.41042500
103IRAK40.40015909
104CDK11A0.39877290
105YES10.39399247
106GRK60.38539277
107CDK150.38425300
108CDK90.38394242
109AKT20.37829393
110BRD40.36574929
111DAPK10.35545323
112MAP3K40.34544359
113LIMK10.34217864
114SMG10.34014162
115FGFR10.33821620
116RPS6KL10.29742366
117RPS6KC10.29742366
118IRAK30.28904143
119BLK0.27988235
120KSR10.27908245
121CDK30.27125806
122RPS6KA60.26942367
123MAPKAPK30.26879542
124TEC0.26581502
125CSNK1E0.25646862
126CSNK1G30.24645246
127MAP4K20.23990057
128ARAF0.23981663
129LYN0.23173672
130PRKDC0.22624141
131ABL20.21929428
132MAP2K60.21384192
133KIT0.16405195
134PDK30.16148511

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.30419300
2Mismatch repair_Homo sapiens_hsa034304.51142956
3Proteasome_Homo sapiens_hsa030503.96630531
4Ribosome_Homo sapiens_hsa030103.88224163
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51452666
6RNA polymerase_Homo sapiens_hsa030203.48627402
7Base excision repair_Homo sapiens_hsa034103.32159934
8* Spliceosome_Homo sapiens_hsa030403.27204284
9Homologous recombination_Homo sapiens_hsa034403.11705648
10Nucleotide excision repair_Homo sapiens_hsa034203.04247832
11RNA transport_Homo sapiens_hsa030132.89530578
12Pyrimidine metabolism_Homo sapiens_hsa002402.69795369
13Cell cycle_Homo sapiens_hsa041102.50490034
14One carbon pool by folate_Homo sapiens_hsa006702.47050963
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36930058
16Fanconi anemia pathway_Homo sapiens_hsa034602.17104885
17Non-homologous end-joining_Homo sapiens_hsa034502.03709220
18RNA degradation_Homo sapiens_hsa030181.85101367
19Basal transcription factors_Homo sapiens_hsa030221.84847602
20Fatty acid elongation_Homo sapiens_hsa000621.63405982
21Steroid biosynthesis_Homo sapiens_hsa001001.58996768
22Pyruvate metabolism_Homo sapiens_hsa006201.56742105
23mRNA surveillance pathway_Homo sapiens_hsa030151.49110405
24Purine metabolism_Homo sapiens_hsa002301.46308332
25p53 signaling pathway_Homo sapiens_hsa041151.41198306
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27028385
27Propanoate metabolism_Homo sapiens_hsa006401.25061659
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17153393
29Parkinsons disease_Homo sapiens_hsa050121.08235574
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07546830
31Huntingtons disease_Homo sapiens_hsa050161.01327306
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92799513
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.91095838
34Protein export_Homo sapiens_hsa030600.90625235
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90493980
36Pentose phosphate pathway_Homo sapiens_hsa000300.89328906
37Oxidative phosphorylation_Homo sapiens_hsa001900.87304821
38Systemic lupus erythematosus_Homo sapiens_hsa053220.86815203
39Sulfur metabolism_Homo sapiens_hsa009200.85011812
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84682788
41Biosynthesis of amino acids_Homo sapiens_hsa012300.84536888
42Folate biosynthesis_Homo sapiens_hsa007900.83980430
43Cardiac muscle contraction_Homo sapiens_hsa042600.83355710
44Antigen processing and presentation_Homo sapiens_hsa046120.81025845
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80948043
46Herpes simplex infection_Homo sapiens_hsa051680.78061305
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76125500
48Oocyte meiosis_Homo sapiens_hsa041140.75231273
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75090232
50Primary immunodeficiency_Homo sapiens_hsa053400.72202589
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.71755851
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.71017569
53Viral carcinogenesis_Homo sapiens_hsa052030.68845201
54Sulfur relay system_Homo sapiens_hsa041220.66163333
55Selenocompound metabolism_Homo sapiens_hsa004500.63990465
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63591037
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63014686
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62527384
59Glutathione metabolism_Homo sapiens_hsa004800.62218549
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61979442
61Carbon metabolism_Homo sapiens_hsa012000.60189435
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60003934
63Fatty acid metabolism_Homo sapiens_hsa012120.59236000
64HTLV-I infection_Homo sapiens_hsa051660.57961572
65Butanoate metabolism_Homo sapiens_hsa006500.51778376
66Fructose and mannose metabolism_Homo sapiens_hsa000510.46186741
67Legionellosis_Homo sapiens_hsa051340.45421717
68Vitamin B6 metabolism_Homo sapiens_hsa007500.42646198
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41888289
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40843906
71N-Glycan biosynthesis_Homo sapiens_hsa005100.40388770
72Alzheimers disease_Homo sapiens_hsa050100.39383961
73Peroxisome_Homo sapiens_hsa041460.38998088
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36896866
75Hedgehog signaling pathway_Homo sapiens_hsa043400.36805798
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36100218
77Thyroid cancer_Homo sapiens_hsa052160.35670272
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35180760
79Apoptosis_Homo sapiens_hsa042100.34973024
80Metabolic pathways_Homo sapiens_hsa011000.32970173
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32215726
82Small cell lung cancer_Homo sapiens_hsa052220.31969609
83Wnt signaling pathway_Homo sapiens_hsa043100.31180025
84Galactose metabolism_Homo sapiens_hsa000520.31051775
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30550086
86Measles_Homo sapiens_hsa051620.27077300
87Fatty acid degradation_Homo sapiens_hsa000710.26335223
88Vibrio cholerae infection_Homo sapiens_hsa051100.24912840
89MicroRNAs in cancer_Homo sapiens_hsa052060.24697815
90Shigellosis_Homo sapiens_hsa051310.24521209
91beta-Alanine metabolism_Homo sapiens_hsa004100.24408338
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22743490
93Alcoholism_Homo sapiens_hsa050340.22199679
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21999565
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.20307600
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20181128
97Tyrosine metabolism_Homo sapiens_hsa003500.19415710
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18911218
99Colorectal cancer_Homo sapiens_hsa052100.18889718
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17810363
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17750711
102Allograft rejection_Homo sapiens_hsa053300.17632883
103Hepatitis B_Homo sapiens_hsa051610.16866123
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.16309920
105Viral myocarditis_Homo sapiens_hsa054160.15421280
106Hematopoietic cell lineage_Homo sapiens_hsa046400.15208693
107Basal cell carcinoma_Homo sapiens_hsa052170.14725633
108Arachidonic acid metabolism_Homo sapiens_hsa005900.13380945
109Arginine biosynthesis_Homo sapiens_hsa002200.13262643
110Phenylalanine metabolism_Homo sapiens_hsa003600.13031180
111Hippo signaling pathway_Homo sapiens_hsa043900.12807940
112Adherens junction_Homo sapiens_hsa045200.11907657
113HIF-1 signaling pathway_Homo sapiens_hsa040660.11466099
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11279216
115Regulation of autophagy_Homo sapiens_hsa041400.11204684
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.10834575
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09726282
118Asthma_Homo sapiens_hsa053100.09468057
119Fat digestion and absorption_Homo sapiens_hsa049750.09184709
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.09158593
121Influenza A_Homo sapiens_hsa051640.08965031
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08778418
123TGF-beta signaling pathway_Homo sapiens_hsa043500.08711180
124Arginine and proline metabolism_Homo sapiens_hsa003300.08422198
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08177720
126Lysine degradation_Homo sapiens_hsa003100.08101225
127Pathways in cancer_Homo sapiens_hsa052000.07917674
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07760647
129Tight junction_Homo sapiens_hsa045300.07270924
130Notch signaling pathway_Homo sapiens_hsa043300.06963697

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