PPIF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.02280702
2DNA deamination (GO:0045006)4.89944370
3tricarboxylic acid cycle (GO:0006099)4.88074074
4ribosomal small subunit assembly (GO:0000028)4.77391437
5oxidative phosphorylation (GO:0006119)4.56089115
6regulation of vitamin D biosynthetic process (GO:0060556)4.37255101
7lipopolysaccharide-mediated signaling pathway (GO:0031663)4.27323091
8lysine catabolic process (GO:0006554)4.15119921
9lysine metabolic process (GO:0006553)4.15119921
10negative regulation of interleukin-12 production (GO:0032695)4.05817440
11viral transcription (GO:0019083)4.02643067
122-oxoglutarate metabolic process (GO:0006103)3.96357335
13low-density lipoprotein particle clearance (GO:0034383)3.95390007
14glycosphingolipid catabolic process (GO:0046479)3.92937162
15translational termination (GO:0006415)3.92804101
16sarcomere organization (GO:0045214)3.92310031
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89927857
18translational elongation (GO:0006414)3.76883324
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67403182
20ATP synthesis coupled proton transport (GO:0015986)3.67403182
21protein localization to endosome (GO:0036010)3.64330811
22NADH metabolic process (GO:0006734)3.62973361
23positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.61272549
24NIK/NF-kappaB signaling (GO:0038061)3.59788486
25DNA strand elongation involved in DNA replication (GO:0006271)3.57812573
26negative regulation of erythrocyte differentiation (GO:0045647)3.57267731
27glycolipid catabolic process (GO:0019377)3.55406559
28folic acid metabolic process (GO:0046655)3.54367987
29telomere maintenance via semi-conservative replication (GO:0032201)3.53756876
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.52743465
31folic acid-containing compound biosynthetic process (GO:0009396)3.51153030
32pinocytosis (GO:0006907)3.49953569
33regulation of vitamin metabolic process (GO:0030656)3.48579770
34oxaloacetate metabolic process (GO:0006107)3.47084535
35DNA strand elongation (GO:0022616)3.38442732
36tricarboxylic acid metabolic process (GO:0072350)3.36655147
37glycine metabolic process (GO:0006544)3.36434104
38cardiac myofibril assembly (GO:0055003)3.35597053
39cellular response to thyroid hormone stimulus (GO:0097067)3.34881141
40positive regulation of chemokine biosynthetic process (GO:0045080)3.31144079
41oligosaccharide catabolic process (GO:0009313)3.30372164
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28590027
43neutrophil activation involved in immune response (GO:0002283)3.27520469
44maturation of SSU-rRNA (GO:0030490)3.26995139
45formation of translation preinitiation complex (GO:0001731)3.25937231
46ribosomal small subunit biogenesis (GO:0042274)3.25224952
47valine metabolic process (GO:0006573)3.23960963
48nucleobase biosynthetic process (GO:0046112)3.23436456
49translational initiation (GO:0006413)3.22882402
50negative regulation of myeloid cell apoptotic process (GO:0033033)3.20826616
51aspartate family amino acid catabolic process (GO:0009068)3.19731038
52DNA replication initiation (GO:0006270)3.19283099
53regulation of podosome assembly (GO:0071801)3.19126353
54response to thyroid hormone (GO:0097066)3.18686869
55protein targeting to ER (GO:0045047)3.16723905
56cotranslational protein targeting to membrane (GO:0006613)3.14841368
57carnitine shuttle (GO:0006853)3.11551658
58positive regulation by symbiont of host defense response (GO:0052509)3.11454944
59modulation by symbiont of host defense response (GO:0052031)3.11454944
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11454944
61modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11454944
62positive regulation by organism of defense response of other organism involved in symbiotic interact3.11454944
63modulation by symbiont of host immune response (GO:0052553)3.11454944
64pteridine-containing compound biosynthetic process (GO:0042559)3.10805511
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09618594
66IMP biosynthetic process (GO:0006188)3.06271831
67regulation of early endosome to late endosome transport (GO:2000641)3.06076832
68regulation of coenzyme metabolic process (GO:0051196)3.05597389
69regulation of cofactor metabolic process (GO:0051193)3.05597389
70purine nucleobase biosynthetic process (GO:0009113)3.04545300
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04312802
72DNA unwinding involved in DNA replication (GO:0006268)3.04176844
73fatty acid beta-oxidation (GO:0006635)3.04112101
74regulation of acyl-CoA biosynthetic process (GO:0050812)3.03573536
75glyoxylate metabolic process (GO:0046487)3.02267648
76protein localization to endoplasmic reticulum (GO:0070972)3.00959777
77succinate metabolic process (GO:0006105)2.99630491
78macrophage activation involved in immune response (GO:0002281)2.99281438
79respiratory electron transport chain (GO:0022904)2.98942838
80IMP metabolic process (GO:0046040)2.97649610
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96269680
82ribosomal large subunit biogenesis (GO:0042273)2.95499080
83quinone biosynthetic process (GO:1901663)2.95417380
84ubiquinone biosynthetic process (GO:0006744)2.95417380
85regulation of superoxide anion generation (GO:0032928)2.94837124
86ceramide catabolic process (GO:0046514)2.92495192
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91660985
88viral life cycle (GO:0019058)2.90774537
89aerobic respiration (GO:0009060)2.90755817
90electron transport chain (GO:0022900)2.90467078
91cellular protein complex disassembly (GO:0043624)2.87982803
92regulation of mononuclear cell migration (GO:0071675)2.87964290
93cardiac muscle cell development (GO:0055013)2.87130791
94telomere maintenance via recombination (GO:0000722)2.86592700
95regulation of cholesterol storage (GO:0010885)2.86095061
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85659506
97fatty acid transmembrane transport (GO:1902001)2.84784708
98pseudouridine synthesis (GO:0001522)2.83214021
99germinal center formation (GO:0002467)2.83119104
100serine family amino acid biosynthetic process (GO:0009070)2.82418349
101AMP metabolic process (GO:0046033)2.81625448
102regulation of membrane protein ectodomain proteolysis (GO:0051043)2.81208990
103ribonucleoprotein complex biogenesis (GO:0022613)2.80690670
104mitochondrial RNA metabolic process (GO:0000959)2.80388407
105detection of molecule of bacterial origin (GO:0032490)2.80112369
106myofibril assembly (GO:0030239)2.79821514
107branched-chain amino acid catabolic process (GO:0009083)2.78454187
108carnitine metabolic process (GO:0009437)2.77450673
109cardiac muscle contraction (GO:0060048)2.75748241
110myeloid dendritic cell differentiation (GO:0043011)2.75621956
111heart process (GO:0003015)2.75203992
112heart contraction (GO:0060047)2.75203992
113galactose catabolic process (GO:0019388)2.75121779
114regulation of chemokine biosynthetic process (GO:0045073)2.74184420
115translation (GO:0006412)2.68239405
116membrane lipid catabolic process (GO:0046466)2.67701264
117response to muramyl dipeptide (GO:0032495)2.67450032
118modulation by symbiont of host cellular process (GO:0044068)2.67391122
119branched-chain amino acid metabolic process (GO:0009081)2.67099388
120amino-acid betaine metabolic process (GO:0006577)2.66812095
121transcription from mitochondrial promoter (GO:0006390)2.66337205
122ribosome biogenesis (GO:0042254)2.66006260
123epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65816028
124fatty acid catabolic process (GO:0009062)2.65205802
125serine family amino acid metabolic process (GO:0009069)2.64702875
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64644993
127activation of MAPKKK activity (GO:0000185)2.63160933
128T-helper 1 type immune response (GO:0042088)2.62888132
129cardiac cell development (GO:0055006)2.62593555
130COPI coating of Golgi vesicle (GO:0048205)2.62184452
131Golgi transport vesicle coating (GO:0048200)2.62184452
132negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61377144
133regulation of mitochondrial translation (GO:0070129)2.61366922
134telomere maintenance via telomere lengthening (GO:0010833)2.61299587
135ethanol oxidation (GO:0006069)2.61216293
136pentose-phosphate shunt (GO:0006098)2.60682441
137fatty acid oxidation (GO:0019395)2.60161100
138regulation of sulfur metabolic process (GO:0042762)2.60104806
139heme biosynthetic process (GO:0006783)2.59011561
140negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.58708314
141sphingolipid catabolic process (GO:0030149)2.57425876
142actin-myosin filament sliding (GO:0033275)2.55872147
143muscle filament sliding (GO:0030049)2.55872147
144aspartate family amino acid metabolic process (GO:0009066)2.55607346
145purine nucleoside monophosphate biosynthetic process (GO:0009127)2.54719885
146purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.54719885
147regulation of integrin activation (GO:0033623)2.54325097
148protein complex disassembly (GO:0043241)2.54070180
149cellular response to lipopolysaccharide (GO:0071222)2.53608448
150regulation of mast cell degranulation (GO:0043304)2.52852859
151positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52342581
152mitotic chromosome condensation (GO:0007076)2.51698136
153lipid oxidation (GO:0034440)2.51257290
154mitotic recombination (GO:0006312)2.50839394
155cellular protein complex localization (GO:0034629)2.50014658
156regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49684620
157positive regulation of cellular amide metabolic process (GO:0034250)2.49609207
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.48478559
159immunoglobulin mediated immune response (GO:0016064)2.45493453
160granulocyte activation (GO:0036230)2.44706031
161cellular extravasation (GO:0045123)2.43735885
162regulation of leukocyte degranulation (GO:0043300)2.42769419
163cellular response to molecule of bacterial origin (GO:0071219)2.42702427
164decidualization (GO:0046697)2.41348346
165response to progesterone (GO:0032570)2.39359362
166regulation of translational termination (GO:0006449)2.36822964
167monocyte chemotaxis (GO:0002548)2.34973574
168regulation of cytokine secretion involved in immune response (GO:0002739)2.34390231
169positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34115629
170positive regulation of extracellular matrix organization (GO:1903055)2.33830434
171negative regulation of cytokine production involved in immune response (GO:0002719)2.33632630
172pyrimidine nucleoside salvage (GO:0043097)2.33617860
173pyrimidine-containing compound salvage (GO:0008655)2.33617860
174myeloid dendritic cell activation (GO:0001773)2.33476187
175positive regulation of NF-kappaB import into nucleus (GO:0042346)2.32900314
176positive regulation of interleukin-6 production (GO:0032755)2.32585266
1773-UTR-mediated mRNA stabilization (GO:0070935)2.30457757
178response to laminar fluid shear stress (GO:0034616)2.30215967
179adenosine receptor signaling pathway (GO:0001973)2.29575635
180* cellular response to arsenic-containing substance (GO:0071243)2.29048900
181detection of other organism (GO:0098543)2.26822620
182detection of external biotic stimulus (GO:0098581)2.26667578
183proline biosynthetic process (GO:0006561)2.26379432
184amino sugar catabolic process (GO:0046348)2.26132968
185positive regulation of Cdc42 GTPase activity (GO:0043089)2.25820702
186stress fiber assembly (GO:0043149)2.25717536
187regulation of fever generation (GO:0031620)2.25450645
188regulation of type I interferon-mediated signaling pathway (GO:0060338)2.23955493
189regulation of interferon-beta biosynthetic process (GO:0045357)2.23396734
190NADPH regeneration (GO:0006740)2.23386806
191nucleobase-containing small molecule interconversion (GO:0015949)2.23087500
192TRIF-dependent toll-like receptor signaling pathway (GO:0035666)2.19998314
193regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.19509044
194toll-like receptor 3 signaling pathway (GO:0034138)2.19450566
195regulation of macrophage chemotaxis (GO:0010758)2.19292963
196cellular response to biotic stimulus (GO:0071216)2.17831134
197hyaluronan catabolic process (GO:0030214)2.16948248
198positive regulation of transcription factor import into nucleus (GO:0042993)2.16063404
199regulation of mast cell activation involved in immune response (GO:0033006)2.15623569
200glucose 6-phosphate metabolic process (GO:0051156)2.15224375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.35199865
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.33054473
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75463042
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60615524
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34016383
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58094232
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49593283
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.49547402
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47651345
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40661084
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.33284281
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29254564
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27681247
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.18426811
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.17522167
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12670681
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04586145
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.03598735
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99564351
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.97052340
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95414587
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95413882
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91079955
24XRN2_22483619_ChIP-Seq_HELA_Human1.90045503
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89098726
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88861681
27* LXR_22292898_ChIP-Seq_THP-1_Human1.84740211
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83408545
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82951540
30* MYC_22102868_ChIP-Seq_BL_Human1.82862198
31* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80683441
32ZNF263_19887448_ChIP-Seq_K562_Human1.78883898
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78720474
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77538306
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77438369
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76500764
37* VDR_24763502_ChIP-Seq_THP-1_Human1.68273805
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67971587
39* VDR_23849224_ChIP-Seq_CD4+_Human1.67781387
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67005956
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.65687808
42DCP1A_22483619_ChIP-Seq_HELA_Human1.63325611
43GATA1_22025678_ChIP-Seq_K562_Human1.63012207
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62295041
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61975970
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60983184
47FOXP3_21729870_ChIP-Seq_TREG_Human1.60214004
48* GABP_19822575_ChIP-Seq_HepG2_Human1.60064189
49* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59755863
50* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57685048
51CIITA_25753668_ChIP-Seq_RAJI_Human1.57370059
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55433443
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.54623345
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54231905
55RACK7_27058665_Chip-Seq_MCF-7_Human1.54173065
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.53337766
57VDR_21846776_ChIP-Seq_THP-1_Human1.53192283
58* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53064433
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48369511
60CLOCK_20551151_ChIP-Seq_293T_Human1.48147753
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.47390863
62TCF7_22412390_ChIP-Seq_EML_Mouse1.46656478
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45031331
64TFEB_21752829_ChIP-Seq_HELA_Human1.43780263
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43600352
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43151595
67SCL_19346495_ChIP-Seq_HPC-7_Human1.42754705
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42331728
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41723383
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40040048
71AR_21909140_ChIP-Seq_LNCAP_Human1.39570491
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37364332
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35376061
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34643693
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33533863
76* RUNX1_22412390_ChIP-Seq_EML_Mouse1.33498599
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.33185121
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.32580835
79* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30830528
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30829304
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30522195
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28871474
83KDM2B_26808549_Chip-Seq_DND41_Human1.28456241
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28371624
85* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28345282
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27846013
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26742312
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24691111
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.24209368
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23653634
91* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23074106
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23015114
93TTF2_22483619_ChIP-Seq_HELA_Human1.22826105
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22638236
95* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21829063
96* NCOR1_26117541_ChIP-Seq_K562_Human1.21827909
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21614483
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21317071
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18670617
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16995379
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15714396
102* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15458722
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14718798
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14550200
105IRF8_22096565_ChIP-ChIP_GC-B_Human1.14049913
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13890313
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13715682
108LXR_22158963_ChIP-Seq_LIVER_Mouse1.13308208
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12855017
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11703590
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11674982
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11554191
113* MAF_26560356_Chip-Seq_TH2_Human1.11286183
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09831050
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09283635
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08520321
117KDM5A_27292631_Chip-Seq_BREAST_Human1.07977204
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07842285
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06809979
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06539234
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05612905
122SPI1_23127762_ChIP-Seq_K562_Human1.03683186
123* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03359862
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02898605
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02033754
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01864503
127CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01750063
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01423873
129* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01011937
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.99967099
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.99875533
132* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97571707
133MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96837239
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96704040
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96314104
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95889375
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95062888
138MAF_26560356_Chip-Seq_TH1_Human0.94717332
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94621671
140SPI1_23547873_ChIP-Seq_NB4_Human0.94444412
141* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93898809
142* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91695454
143BCL6_27268052_Chip-Seq_Bcells_Human0.89575639
144* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89346871
145ATF3_27146783_Chip-Seq_COLON_Human0.88227926
146ELK3_25401928_ChIP-Seq_HUVEC_Human0.87555709
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87093972
148* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86995744
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86988785
150UTX_26944678_Chip-Seq_JUKART_Human0.86168188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.22979638
2MP0003303_peritoneal_inflammation3.76967465
3MP0002837_dystrophic_cardiac_calcinosis3.70913100
4MP0005058_abnormal_lysosome_morphology3.68802576
5MP0003806_abnormal_nucleotide_metabolis3.65377769
6MP0004084_abnormal_cardiac_muscle3.65061166
7MP0005451_abnormal_body_composition3.34092235
8MP0004215_abnormal_myocardial_fiber3.09088661
9MP0003436_decreased_susceptibility_to2.86368050
10MP0005330_cardiomyopathy2.74292651
11MP0002139_abnormal_hepatobiliary_system2.72662656
12MP0004510_myositis2.63722185
13MP0005360_urolithiasis2.63204702
14MP0005085_abnormal_gallbladder_physiolo2.47230494
15MP0000751_myopathy2.46937798
16* MP0006036_abnormal_mitochondrial_physio2.41242786
17MP0002148_abnormal_hypersensitivity_rea2.36565444
18MP0002396_abnormal_hematopoietic_system2.33733136
19MP0003693_abnormal_embryo_hatching2.28230508
20MP0004036_abnormal_muscle_relaxation2.27054269
21MP0002877_abnormal_melanocyte_morpholog2.25721082
22MP0005365_abnormal_bile_salt2.25354799
23MP0003453_abnormal_keratinocyte_physiol2.21319653
24MP0003300_gastrointestinal_ulcer2.09970601
25MP0004947_skin_inflammation2.05343963
26MP0000749_muscle_degeneration2.03177551
27MP0009278_abnormal_bone_marrow2.00252293
28MP0009840_abnormal_foam_cell2.00048888
29MP0002419_abnormal_innate_immunity1.93936371
30MP0003221_abnormal_cardiomyocyte_apopto1.91873860
31MP0009785_altered_susceptibility_to1.91249067
32MP0008775_abnormal_heart_ventricle1.89302352
33MP0004957_abnormal_blastocyst_morpholog1.82839028
34MP0010630_abnormal_cardiac_muscle1.81900673
35MP0005000_abnormal_immune_tolerance1.81435411
36MP0000858_altered_metastatic_potential1.80485873
37MP0006082_CNS_inflammation1.79539502
38MP0005385_cardiovascular_system_phenoty1.76333638
39MP0001544_abnormal_cardiovascular_syste1.76333638
40MP0005464_abnormal_platelet_physiology1.76023939
41MP0003656_abnormal_erythrocyte_physiolo1.75623444
42MP0008260_abnormal_autophagy1.74412003
43MP0004087_abnormal_muscle_fiber1.71092489
44MP0010094_abnormal_chromosome_stability1.69572626
45MP0002269_muscular_atrophy1.67898081
46MP0005025_abnormal_response_to1.66361808
47MP0006035_abnormal_mitochondrial_morpho1.65390536
48MP0004147_increased_porphyrin_level1.64888623
49MP0003567_abnormal_fetal_cardiomyocyte1.63532166
50MP0003172_abnormal_lysosome_physiology1.63523273
51MP0001835_abnormal_antigen_presentation1.62662340
52MP0008875_abnormal_xenobiotic_pharmacok1.62034809
53MP0000750_abnormal_muscle_regeneration1.61860569
54* MP0003075_altered_response_to1.61407059
55MP0003186_abnormal_redox_activity1.61311774
56MP0005076_abnormal_cell_differentiation1.61039249
57MP0002972_abnormal_cardiac_muscle1.59663218
58MP0004130_abnormal_muscle_cell1.57711952
59MP0005319_abnormal_enzyme/_coenzyme1.55961410
60MP0003111_abnormal_nucleus_morphology1.55645840
61MP0010234_abnormal_vibrissa_follicle1.53815034
62MP0003137_abnormal_impulse_conducting1.50108532
63MP0009764_decreased_sensitivity_to1.48312756
64MP0000604_amyloidosis1.47575292
65MP0003077_abnormal_cell_cycle1.45446683
66MP0004185_abnormal_adipocyte_glucose1.45150334
67MP0004233_abnormal_muscle_weight1.45036205
68MP0003448_altered_tumor_morphology1.44099553
69MP0002452_abnormal_antigen_presenting1.43280473
70MP0001533_abnormal_skeleton_physiology1.42496571
71MP0002796_impaired_skin_barrier1.40775311
72MP0002998_abnormal_bone_remodeling1.40603809
73MP0003724_increased_susceptibility_to1.39817738
74MP0003828_pulmonary_edema1.38395601
75MP0006138_congestive_heart_failure1.38220263
76MP0002723_abnormal_immune_serum1.36696003
77MP0001790_abnormal_immune_system1.36118261
78MP0005387_immune_system_phenotype1.36118261
79MP0005266_abnormal_metabolism1.34075465
80MP0005332_abnormal_amino_acid1.33300443
81MP0005397_hematopoietic_system_phenotyp1.33110270
82MP0001545_abnormal_hematopoietic_system1.33110270
83MP0002106_abnormal_muscle_physiology1.30811761
84MP0003566_abnormal_cell_adhesion1.29551238
85MP0010352_gastrointestinal_tract_polyps1.29306941
86MP0008004_abnormal_stomach_pH1.23995553
87MP0001853_heart_inflammation1.23464437
88MP0001845_abnormal_inflammatory_respons1.23192858
89MP0004484_altered_response_of1.20545565
90MP0005671_abnormal_response_to1.18623920
91MP0002420_abnormal_adaptive_immunity1.18560272
92MP0001819_abnormal_immune_cell1.17995708
93MP0001800_abnormal_humoral_immune1.17978164
94MP0005083_abnormal_biliary_tract1.17570702
95MP0010329_abnormal_lipoprotein_level1.17549157
96MP0010155_abnormal_intestine_physiology1.17012123
97MP0000609_abnormal_liver_physiology1.15967137
98MP0002405_respiratory_system_inflammati1.11773566
99MP0004808_abnormal_hematopoietic_stem1.11012076
100MP0005620_abnormal_muscle_contractility1.11004755
101MP0000490_abnormal_crypts_of1.10618231
102MP0005666_abnormal_adipose_tissue1.10524618
103MP0003191_abnormal_cellular_cholesterol1.10036104
104MP0001849_ear_inflammation1.09826698
105MP0000747_muscle_weakness1.09603868
106MP0010307_abnormal_tumor_latency1.06880364
107MP0003252_abnormal_bile_duct1.06432359
108MP0008057_abnormal_DNA_replication1.03993884
109MP0003091_abnormal_cell_migration1.03881410
110MP0001216_abnormal_epidermal_layer1.03471415
111MP0005670_abnormal_white_adipose1.03067646
112MP0010368_abnormal_lymphatic_system1.01891482
113MP0005584_abnormal_enzyme/coenzyme_acti1.01781146
114MP0008058_abnormal_DNA_repair1.00539711
115MP0001666_abnormal_nutrient_absorption1.00244264
116MP0005501_abnormal_skin_physiology0.99735705
117MP0001764_abnormal_homeostasis0.98464517
118MP0008007_abnormal_cellular_replicative0.97767529
119MP0005023_abnormal_wound_healing0.97682022
120MP0002127_abnormal_cardiovascular_syste0.97482074
121MP0002332_abnormal_exercise_endurance0.96916490
122MP0006054_spinal_hemorrhage0.96628135
123* MP0005166_decreased_susceptibility_to0.96561075
124MP0009643_abnormal_urine_homeostasis0.96338135
125MP0001727_abnormal_embryo_implantation0.94524124
126MP0003705_abnormal_hypodermis_morpholog0.92451887
127MP0000598_abnormal_liver_morphology0.92198836
128MP0000716_abnormal_immune_system0.91374728
129MP0003763_abnormal_thymus_physiology0.91151675
130MP0003984_embryonic_growth_retardation0.90219313
131MP0002429_abnormal_blood_cell0.89967840
132MP0002254_reproductive_system_inflammat0.89621207
133MP0005310_abnormal_salivary_gland0.88927726
134MP0005369_muscle_phenotype0.88511421
135MP0003329_amyloid_beta_deposits0.88448846
136MP0002088_abnormal_embryonic_growth/wei0.87164350
137MP0000759_abnormal_skeletal_muscle0.87127498
138* MP0000343_altered_response_to0.86623962
139MP0001730_embryonic_growth_arrest0.86181626
140MP0005167_abnormal_blood-brain_barrier0.85242617
141MP0009333_abnormal_splenocyte_physiolog0.85129020
142MP0002019_abnormal_tumor_incidence0.84026225
143MP0009763_increased_sensitivity_to0.83837203
144MP0000358_abnormal_cell_content/0.83212767
145MP0000266_abnormal_heart_morphology0.81207067
146MP0004858_abnormal_nervous_system0.80376735
147MP0002118_abnormal_lipid_homeostasis0.78892558
148MP0005375_adipose_tissue_phenotype0.78189887
149MP0005165_increased_susceptibility_to0.75999997
150MP0002080_prenatal_lethality0.75697314
151MP0001672_abnormal_embryogenesis/_devel0.75677259
152MP0005380_embryogenesis_phenotype0.75677259
153MP0000689_abnormal_spleen_morphology0.75565858
154MP0004085_abnormal_heartbeat0.75067952
155MP0008469_abnormal_protein_level0.74599765
156MP0002722_abnormal_immune_system0.74473076
157MP0001873_stomach_inflammation0.74247377
158MP0002398_abnormal_bone_marrow0.73551974
159MP0002132_abnormal_respiratory_system0.72315363
160* MP0000313_abnormal_cell_death0.70854106
161MP0003690_abnormal_glial_cell0.70016714
162MP0005164_abnormal_response_to0.69959123
163MP0000350_abnormal_cell_proliferation0.69247908
164MP0000685_abnormal_immune_system0.69180311
165MP0005376_homeostasis/metabolism_phenot0.68750056
166MP0005636_abnormal_mineral_homeostasis0.68724914

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.05869858
2Abnormality of liposaccharide metabolism (HP:0010968)5.05869858
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.05869858
4Ventricular tachycardia (HP:0004756)4.36336324
5Sudden death (HP:0001699)4.23267216
6Hepatic necrosis (HP:0002605)4.17400902
7Abnormality of cells of the erythroid lineage (HP:0012130)3.87441931
8Abnormal number of erythroid precursors (HP:0012131)3.84519939
9Increased cerebral lipofuscin (HP:0011813)3.82549000
10Myoglobinuria (HP:0002913)3.74634487
11Abnormality of macrophages (HP:0004311)3.70208390
12Hepatocellular necrosis (HP:0001404)3.70143582
13Dicarboxylic aciduria (HP:0003215)3.69009654
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.69009654
15Rhabdomyolysis (HP:0003201)3.68857786
16Palpitations (HP:0001962)3.61914560
17Hypoglycemic coma (HP:0001325)3.56906774
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.52172487
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.52172487
20Abnormality of fatty-acid metabolism (HP:0004359)3.46177997
21Lipoatrophy (HP:0100578)3.43080950
22Increased muscle lipid content (HP:0009058)3.40241946
23Hyperammonemia (HP:0001987)3.37313969
24Ragged-red muscle fibers (HP:0003200)3.29546679
25Vacuolated lymphocytes (HP:0001922)3.27366418
26Loss of speech (HP:0002371)3.26895755
27Dysostosis multiplex (HP:0000943)3.24030291
28Increased intramyocellular lipid droplets (HP:0012240)3.15263928
29Cerebral edema (HP:0002181)3.14164560
30Increased neuronal autofluorescent lipopigment (HP:0002074)3.13176082
31Lactic acidosis (HP:0003128)3.12770508
32Exercise-induced muscle cramps (HP:0003710)3.09173455
33Abnormality of the left ventricular outflow tract (HP:0011103)3.08774103
34Subaortic stenosis (HP:0001682)3.08774103
35Abnormal mitochondria in muscle tissue (HP:0008316)3.06640194
36Dilated cardiomyopathy (HP:0001644)3.02436782
37Increased CSF lactate (HP:0002490)3.00740394
38Ketosis (HP:0001946)3.00642970
39Systemic lupus erythematosus (HP:0002725)2.99561285
40Myocardial infarction (HP:0001658)2.98721906
41Right ventricular cardiomyopathy (HP:0011663)2.96834598
42Increased serum lactate (HP:0002151)2.93322672
43Atrial fibrillation (HP:0005110)2.90058272
44Acute encephalopathy (HP:0006846)2.89249687
45Generalized aminoaciduria (HP:0002909)2.88301748
46Mitochondrial inheritance (HP:0001427)2.87463317
47Vertebral compression fractures (HP:0002953)2.86723531
48Axonal loss (HP:0003447)2.84688994
49Hyperglycinuria (HP:0003108)2.83914662
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83661216
51Supraventricular tachycardia (HP:0004755)2.83349052
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82251893
53Abnormality of alanine metabolism (HP:0010916)2.82251893
54Hyperalaninemia (HP:0003348)2.82251893
55Ketoacidosis (HP:0001993)2.81725290
56Acute necrotizing encephalopathy (HP:0006965)2.81213526
57Progressive muscle weakness (HP:0003323)2.79793253
58Eczematoid dermatitis (HP:0000976)2.78994344
59Multiple enchondromatosis (HP:0005701)2.74757128
60Supraventricular arrhythmia (HP:0005115)2.74553438
61Primary atrial arrhythmia (HP:0001692)2.72277052
62Recurrent bacterial skin infections (HP:0005406)2.68750885
63Calf muscle hypertrophy (HP:0008981)2.68442838
64Nausea (HP:0002018)2.68259300
65Recurrent abscess formation (HP:0002722)2.68223931
66Purpura (HP:0000979)2.63608401
67Achilles tendon contracture (HP:0001771)2.62202783
68Lipid accumulation in hepatocytes (HP:0006561)2.60254926
69Upper motor neuron abnormality (HP:0002127)2.56873504
70Atrioventricular block (HP:0001678)2.56863580
71Exercise-induced myalgia (HP:0003738)2.56178925
72Petechiae (HP:0000967)2.53803928
73Nuclear cataract (HP:0100018)2.52228396
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52034438
75Lethargy (HP:0001254)2.50931754
76Abnormality of glycine metabolism (HP:0010895)2.49200069
77Abnormality of serine family amino acid metabolism (HP:0010894)2.49200069
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.48539167
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47635763
80Abnormality of the Achilles tendon (HP:0005109)2.46933126
81Neoplasm of head and neck (HP:0012288)2.46695061
82Esophageal neoplasm (HP:0100751)2.46695061
83Muscle fiber splitting (HP:0003555)2.46078161
84Oral leukoplakia (HP:0002745)2.45993986
85Neurofibrillary tangles (HP:0002185)2.42803872
86Exercise intolerance (HP:0003546)2.42192354
87Mediastinal lymphadenopathy (HP:0100721)2.40395540
88Cerebral inclusion bodies (HP:0100314)2.40008656
89Conjunctival hamartoma (HP:0100780)2.38794131
90Disinhibition (HP:0000734)2.38718766
91Intrahepatic cholestasis (HP:0001406)2.36555209
92Hepatosplenomegaly (HP:0001433)2.36311531
93Neuronal loss in central nervous system (HP:0002529)2.35466570
94Respiratory failure (HP:0002878)2.30005000
95Aplastic anemia (HP:0001915)2.29204284
96Metabolic acidosis (HP:0001942)2.27512415
97Reticulocytopenia (HP:0001896)2.25876305
98Progressive external ophthalmoplegia (HP:0000590)2.25807750
99Abnormal gallbladder physiology (HP:0012438)2.24672207
100Cholecystitis (HP:0001082)2.24672207
101Deep venous thrombosis (HP:0002625)2.24293857
102Asymmetric septal hypertrophy (HP:0001670)2.23173269
103Hyperglycinemia (HP:0002154)2.23084073
104Autoimmune thrombocytopenia (HP:0001973)2.21402529
105Syncope (HP:0001279)2.21358823
106Heart block (HP:0012722)2.20741209
107Muscle hypertrophy of the lower extremities (HP:0008968)2.20130480
108Abnormality of monocarboxylic acid metabolism (HP:0010996)2.19520859
109Abnormality of serum amino acid levels (HP:0003112)2.17413913
110Distal lower limb amyotrophy (HP:0008944)2.17121439
111Increased hepatocellular lipid droplets (HP:0006565)2.16410386
112Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16373296
113Abnormality of polysaccharide metabolism (HP:0011012)2.16373296
114Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16373296
115Abnormality of glycolysis (HP:0004366)2.15873949
116Increased serum pyruvate (HP:0003542)2.15873949
117Amyloidosis (HP:0011034)2.15214576
118Hyperbilirubinemia (HP:0002904)2.14757592
119Chronic obstructive pulmonary disease (HP:0006510)2.14706343
120Obstructive lung disease (HP:0006536)2.14706343
121Increased IgE level (HP:0003212)2.14669596
122Ventricular arrhythmia (HP:0004308)2.13049204
123Progressive macrocephaly (HP:0004481)2.10340884
124Recurrent gram-negative bacterial infections (HP:0005420)2.10024647
125Apathy (HP:0000741)2.09972699
126Bundle branch block (HP:0011710)2.09636571
127Increased serum ferritin (HP:0003281)2.08575403
128Microvesicular hepatic steatosis (HP:0001414)2.07531093
129Thrombocytosis (HP:0001894)2.05644479
130Mucopolysacchariduria (HP:0008155)2.05415884
131Urinary glycosaminoglycan excretion (HP:0003541)2.05415884
132Hypobetalipoproteinemia (HP:0003563)2.05346140
133Macrocytic anemia (HP:0001972)2.04763620
134Diminished motivation (HP:0000745)2.04744768
135Tetraparesis (HP:0002273)2.04557566
136Bone pain (HP:0002653)2.03769156
137Orchitis (HP:0100796)2.03653761
138Abnormal atrioventricular conduction (HP:0005150)2.02930502
139CNS demyelination (HP:0007305)2.02554586
140Abnormality of the calf musculature (HP:0001430)2.02297840
141Abnormality of iron homeostasis (HP:0011031)2.01952378
142Pallor (HP:0000980)2.00241575
143Distal lower limb muscle weakness (HP:0009053)1.98717537
144Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98273899
145Proximal tubulopathy (HP:0000114)1.98158557
146Hypertensive crisis (HP:0100735)1.98039592
147Personality changes (HP:0000751)1.97732711
148Fatigue (HP:0012378)1.96834460
149Recurrent viral infections (HP:0004429)1.96626129
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96554014
151Rough bone trabeculation (HP:0100670)1.96542006
152Abnormality of complement system (HP:0005339)1.95241689
153Vomiting (HP:0002013)1.92020627
154Late onset (HP:0003584)1.91721718
155Segmental peripheral demyelination/remyelination (HP:0003481)1.91630693
156Delayed CNS myelination (HP:0002188)1.91559560
157Xanthomatosis (HP:0000991)1.91496088
158Angiofibromas (HP:0010615)1.90981475
159Adenoma sebaceum (HP:0009720)1.90981475
160Hyporeflexia of lower limbs (HP:0002600)1.89379983
161Glomerulonephritis (HP:0000099)1.88665224
162Centrally nucleated skeletal muscle fibers (HP:0003687)1.87984891
163Increased connective tissue (HP:0009025)1.87228720
164Hyperacusis (HP:0010780)1.86600616
165Progressive neurologic deterioration (HP:0002344)1.86135351
166Pathologic fracture (HP:0002756)1.83660026
167Thoracic kyphosis (HP:0002942)1.82777533
168Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82241448
169Urticaria (HP:0001025)1.80958660
170Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78288392
171Abnormal trabecular bone morphology (HP:0100671)1.76930369
172Hyperparathyroidism (HP:0000843)1.76873249
173Slow saccadic eye movements (HP:0000514)1.73778826
174Myositis (HP:0100614)1.72299344
175Trismus (HP:0000211)1.72125143
176Interstitial pulmonary disease (HP:0006530)1.70748901
177Hemorrhage of the eye (HP:0011885)1.70565756
178Complement deficiency (HP:0004431)1.70196906
179Prolonged neonatal jaundice (HP:0006579)1.69848633
180Hypertriglyceridemia (HP:0002155)1.69422862
181Retrobulbar optic neuritis (HP:0100654)1.69034898
182Optic neuritis (HP:0100653)1.69034898
183Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69027594
184Mutism (HP:0002300)1.66439380
185Abnormal platelet function (HP:0011869)1.66114605
186Impaired platelet aggregation (HP:0003540)1.66114605
187Abnormality of the distal phalanges of the toes (HP:0010182)1.65826571
188Cellulitis (HP:0100658)1.65147207
189Stomatitis (HP:0010280)1.64697530
190Thick nail (HP:0001805)1.64423140
191Abnormality of the thoracic spine (HP:0100711)1.60995384
192Fasciculations (HP:0002380)1.60657617
193Paralysis (HP:0003470)1.59081400

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.91317535
2BCKDK4.16632048
3NME23.26498915
4PKN23.17464323
5PRPF4B3.11456231
6NEK12.99800081
7FLT32.76467143
8WEE12.70106787
9TTN2.48745932
10SMG12.40398412
11MAP3K142.28392275
12EIF2AK12.20028565
13BUB12.11290243
14TRIB32.00910380
15MYLK2.00878137
16ICK1.95029469
17STK161.85581579
18KDR1.84519471
19MAPKAPK31.82315474
20PDK41.81922545
21PDK31.81922545
22RIPK41.78030762
23LMTK21.77879396
24RPS6KB21.74818478
25PIM21.72958412
26EEF2K1.72365854
27MAP4K11.72272208
28CDC71.70422043
29EIF2AK31.68395875
30MAP2K31.68342724
31DDR21.66704732
32CDK121.61777997
33IRAK41.60591252
34MAP3K111.59318153
35STK241.43339952
36BRSK21.42199498
37SCYL21.41440157
38SIK11.40601324
39ARAF1.39748999
40KIT1.37419088
41MAP3K101.36564004
42TIE11.35049214
43OBSCN1.34931028
44TGFBR11.34868980
45MAP3K31.32139890
46ERN11.32064726
47MAP3K131.30445791
48ACVR1B1.27192033
49PINK11.26711260
50RPS6KA41.25626410
51NEK21.24569499
52MAP3K11.23394689
53IRAK21.22555326
54CDK41.20260274
55MUSK1.18875944
56MOS1.16592674
57LATS21.16286745
58EPHA21.14802412
59KSR21.12986314
60FGR1.12090529
61DYRK31.11932279
62BLK1.09496108
63RIPK11.05239430
64STK41.04994084
65IKBKB1.04500741
66TESK11.03048894
67LRRK21.02721629
68ILK1.00694815
69PHKG20.98200931
70PHKG10.98200931
71MAP3K50.95437567
72CDK70.90086353
73CSK0.88849921
74MAPK110.88108453
75CDC42BPA0.86299115
76GRK70.85585430
77BTK0.85516364
78VRK10.84365725
79AURKB0.83899243
80PDK20.80814816
81MAP3K70.78484756
82TEC0.78184394
83CDK60.77793364
84PDGFRA0.77529138
85TYK20.77478242
86CAMK1D0.76913333
87ZAP700.75608162
88MAP3K80.75395441
89TBK10.74082393
90NME10.73247435
91TAOK20.72431875
92PIM10.70997323
93TTK0.70362687
94BRAF0.66591757
95PAK40.64740594
96PDPK10.64566845
97SIK30.64556730
98ATR0.64470099
99BMPR20.64331766
100PBK0.62271387
101MST1R0.62247834
102PLK10.61290386
103BRSK10.60403290
104DMPK0.60079734
105EPHB10.59613390
106IRAK10.58235982
107CSF1R0.56458941
108PRKG20.55658519
109TNIK0.55162450
110TSSK60.54968025
111TAOK10.54095601
112PASK0.53505323
113IKBKE0.53423793
114MATK0.53275694
115JAK30.52638691
116MAP2K60.52555226
117BMX0.52320751
118MTOR0.51938669
119TGFBR20.51415958
120CHUK0.50822628
121PIK3CA0.50581502
122STK100.50404837
123CDK190.49740272
124TESK20.48269586
125ALK0.47216977
126AKT20.46691816
127RPS6KA60.46665889
128RPS6KC10.45300865
129RPS6KL10.45300865
130MAPK40.45016286
131MAP3K90.43549277
132SRPK10.42905513
133CLK10.42850727
134AURKA0.42568760
135MAPK120.42539871
136DAPK30.41978208
137ABL20.41955459
138NLK0.41543128
139CAMK10.41126483
140NEK90.40674271
141PRKAA20.40157741
142CSNK2A20.39740937
143PAK10.39322006
144FGFR40.39227883
145RAF10.38872585
146ZAK0.36649953
147TYRO30.33570928
148JAK20.32009946
149MARK30.30219405
150RPS6KA10.30138753
151PDK10.29709873
152PTK60.29371692
153CDK90.29251711
154CHEK20.28128038
155MAPKAPK20.27181989

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.06594998
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.53025084
3Other glycan degradation_Homo sapiens_hsa005113.36410778
4DNA replication_Homo sapiens_hsa030303.18042133
5Ribosome_Homo sapiens_hsa030102.91708555
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75142921
7Propanoate metabolism_Homo sapiens_hsa006402.53254217
8Fatty acid degradation_Homo sapiens_hsa000712.51639356
9Carbon metabolism_Homo sapiens_hsa012002.40078582
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35652924
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31436992
12Mismatch repair_Homo sapiens_hsa034302.23034174
13Bladder cancer_Homo sapiens_hsa052192.21329588
14Osteoclast differentiation_Homo sapiens_hsa043802.18318379
15Lysosome_Homo sapiens_hsa041422.17483168
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15661916
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.99663268
18Leishmaniasis_Homo sapiens_hsa051401.96906289
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95669023
20Biosynthesis of amino acids_Homo sapiens_hsa012301.94534949
21TNF signaling pathway_Homo sapiens_hsa046681.88846874
22Parkinsons disease_Homo sapiens_hsa050121.87081556
23One carbon pool by folate_Homo sapiens_hsa006701.86637818
24Prion diseases_Homo sapiens_hsa050201.84588537
25Salmonella infection_Homo sapiens_hsa051321.75369864
26Proteasome_Homo sapiens_hsa030501.71572358
27Pyruvate metabolism_Homo sapiens_hsa006201.70714199
28Rheumatoid arthritis_Homo sapiens_hsa053231.67081302
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.66230383
30Oxidative phosphorylation_Homo sapiens_hsa001901.65374875
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64329279
32Base excision repair_Homo sapiens_hsa034101.63981150
33Pyrimidine metabolism_Homo sapiens_hsa002401.63271462
34Folate biosynthesis_Homo sapiens_hsa007901.61766791
35Staphylococcus aureus infection_Homo sapiens_hsa051501.59752671
36Tuberculosis_Homo sapiens_hsa051521.59682984
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58941008
38Fatty acid metabolism_Homo sapiens_hsa012121.57516642
39Pertussis_Homo sapiens_hsa051331.55088435
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54551960
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.53837827
42Sulfur relay system_Homo sapiens_hsa041221.52984974
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.49923635
44Shigellosis_Homo sapiens_hsa051311.49364147
45Malaria_Homo sapiens_hsa051441.47330713
46Influenza A_Homo sapiens_hsa051641.46058582
47Selenocompound metabolism_Homo sapiens_hsa004501.42609057
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40385248
49RNA polymerase_Homo sapiens_hsa030201.40298497
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39492253
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38923901
52Cardiac muscle contraction_Homo sapiens_hsa042601.36107755
53Tryptophan metabolism_Homo sapiens_hsa003801.35780972
54Arginine biosynthesis_Homo sapiens_hsa002201.35257090
55Homologous recombination_Homo sapiens_hsa034401.34431518
56B cell receptor signaling pathway_Homo sapiens_hsa046621.33694039
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33681620
58Chronic myeloid leukemia_Homo sapiens_hsa052201.33193473
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32426146
60Pentose phosphate pathway_Homo sapiens_hsa000301.31990937
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30502153
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28840002
63Apoptosis_Homo sapiens_hsa042101.26865833
64Spliceosome_Homo sapiens_hsa030401.24915269
65Drug metabolism - other enzymes_Homo sapiens_hsa009831.24297065
66Peroxisome_Homo sapiens_hsa041461.23044675
67Nucleotide excision repair_Homo sapiens_hsa034201.22581614
68Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18195544
69beta-Alanine metabolism_Homo sapiens_hsa004101.18098758
70Hepatitis B_Homo sapiens_hsa051611.17813505
71Cyanoamino acid metabolism_Homo sapiens_hsa004601.17637579
72* Toxoplasmosis_Homo sapiens_hsa051451.16774358
73Huntingtons disease_Homo sapiens_hsa050161.15110031
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14775901
75Pancreatic cancer_Homo sapiens_hsa052121.10896873
76Butanoate metabolism_Homo sapiens_hsa006501.08904132
77RNA transport_Homo sapiens_hsa030131.06634297
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04520552
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03725854
80Hepatitis C_Homo sapiens_hsa051601.00711138
81Epstein-Barr virus infection_Homo sapiens_hsa051691.00396077
82Alzheimers disease_Homo sapiens_hsa050101.00241697
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99871623
84VEGF signaling pathway_Homo sapiens_hsa043700.97412549
85Phagosome_Homo sapiens_hsa041450.96697199
86PPAR signaling pathway_Homo sapiens_hsa033200.94289744
87Starch and sucrose metabolism_Homo sapiens_hsa005000.92131904
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89949058
89Measles_Homo sapiens_hsa051620.88897613
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88028770
91Arginine and proline metabolism_Homo sapiens_hsa003300.87215905
92Non-small cell lung cancer_Homo sapiens_hsa052230.86912745
93Vibrio cholerae infection_Homo sapiens_hsa051100.86538252
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86164865
95Galactose metabolism_Homo sapiens_hsa000520.84488169
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84327110
97Amoebiasis_Homo sapiens_hsa051460.83208440
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82652523
99Fatty acid elongation_Homo sapiens_hsa000620.82548638
100Viral carcinogenesis_Homo sapiens_hsa052030.81877372
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81247891
102Caffeine metabolism_Homo sapiens_hsa002320.79012776
103Glutathione metabolism_Homo sapiens_hsa004800.77580503
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76310342
105Fructose and mannose metabolism_Homo sapiens_hsa000510.75836664
106Allograft rejection_Homo sapiens_hsa053300.74163497
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.73621593
108Sphingolipid metabolism_Homo sapiens_hsa006000.73403358
109Cell cycle_Homo sapiens_hsa041100.73042740
110Renal cell carcinoma_Homo sapiens_hsa052110.72258324
111RNA degradation_Homo sapiens_hsa030180.71690442
112Purine metabolism_Homo sapiens_hsa002300.71009057
113Fat digestion and absorption_Homo sapiens_hsa049750.69806932
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69484321
115Chemokine signaling pathway_Homo sapiens_hsa040620.67889925
116HTLV-I infection_Homo sapiens_hsa051660.67827628
117Graft-versus-host disease_Homo sapiens_hsa053320.66944980
118Metabolic pathways_Homo sapiens_hsa011000.66444652
119Nitrogen metabolism_Homo sapiens_hsa009100.65767128
120African trypanosomiasis_Homo sapiens_hsa051430.65460179
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64434106
122Phenylalanine metabolism_Homo sapiens_hsa003600.63519055
123Hematopoietic cell lineage_Homo sapiens_hsa046400.62966676
124Small cell lung cancer_Homo sapiens_hsa052220.62419299
125Lysine degradation_Homo sapiens_hsa003100.61942353
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61722628
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61072383
128Asthma_Homo sapiens_hsa053100.56967267
129Chemical carcinogenesis_Homo sapiens_hsa052040.53542852
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.51515878
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51487647
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51092187
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50789362
134Dilated cardiomyopathy_Homo sapiens_hsa054140.49803350
135Prolactin signaling pathway_Homo sapiens_hsa049170.47849246
136Notch signaling pathway_Homo sapiens_hsa043300.47699282
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46840701
138Insulin signaling pathway_Homo sapiens_hsa049100.45547129
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44901449
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.44790207
141Viral myocarditis_Homo sapiens_hsa054160.43470448
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43230998
143Autoimmune thyroid disease_Homo sapiens_hsa053200.41952924
144Non-homologous end-joining_Homo sapiens_hsa034500.41285718
145p53 signaling pathway_Homo sapiens_hsa041150.41178045
146Fatty acid biosynthesis_Homo sapiens_hsa000610.40929940
147T cell receptor signaling pathway_Homo sapiens_hsa046600.40790706
148Thyroid cancer_Homo sapiens_hsa052160.40666281
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40098584
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36356704
151Complement and coagulation cascades_Homo sapiens_hsa046100.35356646
152Tyrosine metabolism_Homo sapiens_hsa003500.34165859
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.33860720
154Retinol metabolism_Homo sapiens_hsa008300.33427318
155Sulfur metabolism_Homo sapiens_hsa009200.33026468
156Herpes simplex infection_Homo sapiens_hsa051680.32507098
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.31161513
158ABC transporters_Homo sapiens_hsa020100.30928910
159Insulin resistance_Homo sapiens_hsa049310.30398218
160Legionellosis_Homo sapiens_hsa051340.30046380
161Fanconi anemia pathway_Homo sapiens_hsa034600.29551056
162Acute myeloid leukemia_Homo sapiens_hsa052210.28598425
163Bile secretion_Homo sapiens_hsa049760.25783352
164Histidine metabolism_Homo sapiens_hsa003400.24191163
165HIF-1 signaling pathway_Homo sapiens_hsa040660.20154310
166Antigen processing and presentation_Homo sapiens_hsa046120.20044902
167Vitamin digestion and absorption_Homo sapiens_hsa049770.19851201

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