PPIEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of energy homeostasis (GO:2000505)5.05014423
2limb bud formation (GO:0060174)4.37042023
3positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.35487284
4mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.35487284
5establishment of mitochondrion localization (GO:0051654)4.32018983
6tachykinin receptor signaling pathway (GO:0007217)4.26281607
7pyrimidine nucleobase catabolic process (GO:0006208)4.08438915
8negative regulation of mast cell activation (GO:0033004)4.06243467
9axoneme assembly (GO:0035082)3.83073256
10intraciliary transport (GO:0042073)3.79702536
11epithelial cilium movement (GO:0003351)3.79258610
12postsynaptic membrane organization (GO:0001941)3.62079265
13mitochondrion transport along microtubule (GO:0047497)3.57025750
14establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.57025750
15neural tube formation (GO:0001841)3.56535575
16platelet dense granule organization (GO:0060155)3.54363703
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50270769
18photoreceptor cell maintenance (GO:0045494)3.45654051
19negative regulation of neurological system process (GO:0031645)3.44268825
20negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.27804756
21DNA integration (GO:0015074)3.24628369
22DNA double-strand break processing (GO:0000729)3.17958564
23response to pheromone (GO:0019236)3.16748033
24DNA methylation involved in gamete generation (GO:0043046)3.16533840
25activated T cell proliferation (GO:0050798)3.15907729
26peptidyl-histidine modification (GO:0018202)3.15550255
27cilium organization (GO:0044782)3.15264379
28inositol phosphate catabolic process (GO:0071545)3.14565314
29regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.14413519
30cilium movement (GO:0003341)3.14200017
31cilium assembly (GO:0042384)3.13177045
32positive regulation of amino acid transport (GO:0051957)3.06364877
33nucleobase catabolic process (GO:0046113)3.05046543
34presynaptic membrane assembly (GO:0097105)3.04798816
35regulation of cilium movement (GO:0003352)3.02314977
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01876607
37negative regulation of translation, ncRNA-mediated (GO:0040033)3.01876607
38regulation of translation, ncRNA-mediated (GO:0045974)3.01876607
39protein K11-linked deubiquitination (GO:0035871)3.00605747
40piRNA metabolic process (GO:0034587)3.00047823
41ubiquinone biosynthetic process (GO:0006744)2.97515771
42adaptation of signaling pathway (GO:0023058)2.97498070
43retinal cone cell development (GO:0046549)2.93335201
44cilium morphogenesis (GO:0060271)2.90368783
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89560125
46protein polyglutamylation (GO:0018095)2.87013296
47regulation of penile erection (GO:0060405)2.86065690
48ubiquinone metabolic process (GO:0006743)2.85007060
49L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83316737
50regulation of heat generation (GO:0031650)2.82275569
51mannosylation (GO:0097502)2.82252482
52nonmotile primary cilium assembly (GO:0035058)2.80871843
53tryptophan catabolic process (GO:0006569)2.78597859
54indole-containing compound catabolic process (GO:0042436)2.78597859
55indolalkylamine catabolic process (GO:0046218)2.78597859
56regulation of collateral sprouting (GO:0048670)2.78488631
57cytochrome complex assembly (GO:0017004)2.77076099
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74132394
59negative regulation of protein oligomerization (GO:0032460)2.72921292
60positive regulation of uterine smooth muscle contraction (GO:0070474)2.72529151
61regulation of action potential (GO:0098900)2.69915570
62regulation of feeding behavior (GO:0060259)2.69084753
63protein localization to cilium (GO:0061512)2.66952309
64pyrimidine dimer repair (GO:0006290)2.65699938
65positive regulation of amine transport (GO:0051954)2.62917735
66iron-sulfur cluster assembly (GO:0016226)2.62011772
67metallo-sulfur cluster assembly (GO:0031163)2.62011772
68positive regulation of mitochondrial fission (GO:0090141)2.61150156
69acrosome reaction (GO:0007340)2.57020986
70indolalkylamine metabolic process (GO:0006586)2.55650427
71regulation of hexokinase activity (GO:1903299)2.54603978
72regulation of glucokinase activity (GO:0033131)2.54603978
73glycosphingolipid biosynthetic process (GO:0006688)2.54106261
74positive regulation of catecholamine secretion (GO:0033605)2.53442922
75amine catabolic process (GO:0009310)2.51640083
76cellular biogenic amine catabolic process (GO:0042402)2.51640083
77retinal ganglion cell axon guidance (GO:0031290)2.51142876
78regulation of dopamine secretion (GO:0014059)2.50667850
79inner ear receptor stereocilium organization (GO:0060122)2.50608277
80brain morphogenesis (GO:0048854)2.50535879
81tryptophan metabolic process (GO:0006568)2.50251899
82oxidative demethylation (GO:0070989)2.49814018
83negative regulation of thymocyte apoptotic process (GO:0070244)2.49335787
84respiratory chain complex IV assembly (GO:0008535)2.49283106
85energy homeostasis (GO:0097009)2.48510765
86aggressive behavior (GO:0002118)2.48161578
87positive regulation of glycolytic process (GO:0045821)2.48107673
88cellular response to zinc ion (GO:0071294)2.47244573
89behavioral response to nicotine (GO:0035095)2.45969266
90positive regulation of synaptic transmission, GABAergic (GO:0032230)2.45708298
91regulation of telomere maintenance (GO:0032204)2.44692074
92DNA demethylation (GO:0080111)2.43789742
93cellular component assembly involved in morphogenesis (GO:0010927)2.42755653
94amino acid salvage (GO:0043102)2.42602190
95L-methionine salvage (GO:0071267)2.42602190
96L-methionine biosynthetic process (GO:0071265)2.42602190
97glial cell proliferation (GO:0014009)2.42259749
98quinone biosynthetic process (GO:1901663)2.41521080
99coenzyme catabolic process (GO:0009109)2.41111913
100male meiosis (GO:0007140)2.40483508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.49842636
2ZNF274_21170338_ChIP-Seq_K562_Hela4.42085544
3GBX2_23144817_ChIP-Seq_PC3_Human3.51454344
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75088081
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45804628
6VDR_22108803_ChIP-Seq_LS180_Human2.41101257
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32956902
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29081318
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28472775
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25487184
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24495662
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.21593323
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.09636941
14ER_23166858_ChIP-Seq_MCF-7_Human1.93318462
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.91104672
16P300_19829295_ChIP-Seq_ESCs_Human1.88891602
17TAF15_26573619_Chip-Seq_HEK293_Human1.88282646
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83992439
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.83263113
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80463161
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70677007
22CBP_20019798_ChIP-Seq_JUKART_Human1.70677007
23EWS_26573619_Chip-Seq_HEK293_Human1.69798793
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.68575212
25FUS_26573619_Chip-Seq_HEK293_Human1.67636643
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63363654
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63346298
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59629664
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58875770
30EZH2_22144423_ChIP-Seq_EOC_Human1.57256015
31SMAD4_21799915_ChIP-Seq_A2780_Human1.53861045
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.49643652
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49193595
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.48052878
35* AR_25329375_ChIP-Seq_VCAP_Human1.45000825
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44493629
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41952249
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41178178
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41178178
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39320061
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39094363
42VDR_23849224_ChIP-Seq_CD4+_Human1.38508069
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35915617
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34057582
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32839766
46BCAT_22108803_ChIP-Seq_LS180_Human1.31648831
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30522991
48STAT3_23295773_ChIP-Seq_U87_Human1.27766011
49* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26834928
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26602353
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26132954
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25579405
53AR_21572438_ChIP-Seq_LNCaP_Human1.24588157
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.23723023
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23497007
56NANOG_19829295_ChIP-Seq_ESCs_Human1.23164979
57SOX2_19829295_ChIP-Seq_ESCs_Human1.23164979
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20565408
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19830603
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18426749
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18343040
62TCF4_23295773_ChIP-Seq_U87_Human1.17658092
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.15250074
64TP53_22573176_ChIP-Seq_HFKS_Human1.12340632
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11327505
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11298386
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11035933
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.10470645
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.09836813
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09358939
71TCF4_22108803_ChIP-Seq_LS180_Human1.08743482
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.08554059
73ELK1_19687146_ChIP-ChIP_HELA_Human1.06341113
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.04963105
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.04415518
76MYC_18940864_ChIP-ChIP_HL60_Human1.03859673
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03026812
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.02903874
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02092949
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02000523
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01836138
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.01562409
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.01107632
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00338995
85RXR_22108803_ChIP-Seq_LS180_Human0.99990515
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99781225
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99099044
88REST_21632747_ChIP-Seq_MESCs_Mouse0.98804138
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.97241472
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97241472
91IRF1_19129219_ChIP-ChIP_H3396_Human0.96938390
92* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95821807
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94564608
94MYC_19829295_ChIP-Seq_ESCs_Human0.94352557
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.93398091
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.93116141
97* NCOR_22424771_ChIP-Seq_293T_Human0.92852374
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92695627
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92652644
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92126642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.12810949
2MP0003880_abnormal_central_pattern3.41472416
3MP0001984_abnormal_olfaction3.34770315
4MP0001529_abnormal_vocalization3.07344493
5MP0002822_catalepsy2.85317099
6MP0001968_abnormal_touch/_nociception2.52853312
7MP0002653_abnormal_ependyma_morphology2.51268880
8MP0002736_abnormal_nociception_after2.47577011
9MP0003646_muscle_fatigue2.36962129
10MP0005645_abnormal_hypothalamus_physiol2.30122145
11MP0008877_abnormal_DNA_methylation2.26431389
12MP0002102_abnormal_ear_morphology2.19957083
13MP0008995_early_reproductive_senescence2.16333777
14MP0002837_dystrophic_cardiac_calcinosis2.14584112
15MP0005253_abnormal_eye_physiology2.03097685
16MP0002938_white_spotting1.84765715
17MP0006072_abnormal_retinal_apoptosis1.75227219
18MP0008058_abnormal_DNA_repair1.74319286
19MP0002735_abnormal_chemical_nociception1.73167561
20MP0005171_absent_coat_pigmentation1.71908659
21MP0005551_abnormal_eye_electrophysiolog1.70831120
22MP0001501_abnormal_sleep_pattern1.68416782
23MP0001486_abnormal_startle_reflex1.67874299
24MP0001905_abnormal_dopamine_level1.67702007
25MP0003195_calcinosis1.53448768
26MP0005075_abnormal_melanosome_morpholog1.53285461
27MP0008789_abnormal_olfactory_epithelium1.50555602
28MP0005394_taste/olfaction_phenotype1.49603264
29MP0005499_abnormal_olfactory_system1.49603264
30MP0001764_abnormal_homeostasis1.47596490
31MP0000516_abnormal_urinary_system1.43963404
32MP0005367_renal/urinary_system_phenotyp1.43963404
33MP0004043_abnormal_pH_regulation1.43822478
34MP0009046_muscle_twitch1.42767315
35MP0004142_abnormal_muscle_tone1.42267855
36MP0006276_abnormal_autonomic_nervous1.41859980
37MP0002751_abnormal_autonomic_nervous1.40350459
38MP0005671_abnormal_response_to1.34864927
39MP0002638_abnormal_pupillary_reflex1.27523045
40MP0003045_fibrosis1.25151585
41MP0009745_abnormal_behavioral_response1.24009792
42MP0003806_abnormal_nucleotide_metabolis1.22942878
43MP0003122_maternal_imprinting1.21362380
44MP0003172_abnormal_lysosome_physiology1.17943532
45MP0003786_premature_aging1.14398076
46MP0002272_abnormal_nervous_system1.14322394
47MP0003635_abnormal_synaptic_transmissio1.13125669
48MP0003787_abnormal_imprinting1.11522528
49MP0003698_abnormal_male_reproductive1.11478259
50MP0001970_abnormal_pain_threshold1.09502919
51MP0005410_abnormal_fertilization1.06742658
52MP0009697_abnormal_copulation1.03926268
53MP0002064_seizures1.02072875
54MP0001986_abnormal_taste_sensitivity1.00386306
55MP0005310_abnormal_salivary_gland0.98640482
56MP0004924_abnormal_behavior0.96871730
57MP0005386_behavior/neurological_phenoty0.96871730
58MP0006292_abnormal_olfactory_placode0.96321003
59MP0002557_abnormal_social/conspecific_i0.96013034
60MP0002067_abnormal_sensory_capabilities0.95114879
61MP0002572_abnormal_emotion/affect_behav0.94897454
62MP0006036_abnormal_mitochondrial_physio0.94595944
63MP0006082_CNS_inflammation0.93696526
64MP0009785_altered_susceptibility_to0.92277098
65MP0002095_abnormal_skin_pigmentation0.92253926
66MP0005647_abnormal_sex_gland0.91956212
67MP0009764_decreased_sensitivity_to0.89034967
68MP0003633_abnormal_nervous_system0.88215489
69MP0004133_heterotaxia0.87621157
70MP0009278_abnormal_bone_marrow0.86884183
71MP0010386_abnormal_urinary_bladder0.86030558
72MP0001929_abnormal_gametogenesis0.85044851
73MP0002063_abnormal_learning/memory/cond0.82046359
74MP0000383_abnormal_hair_follicle0.81152370
75MP0008872_abnormal_physiological_respon0.81103190
76MP0005174_abnormal_tail_pigmentation0.81091372
77MP0000749_muscle_degeneration0.80691020
78MP0003221_abnormal_cardiomyocyte_apopto0.79588949
79MP0004811_abnormal_neuron_physiology0.78466553
80MP0005391_vision/eye_phenotype0.76275753
81MP0002733_abnormal_thermal_nociception0.75051810
82MP0002752_abnormal_somatic_nervous0.73751452
83MP0002876_abnormal_thyroid_physiology0.73587927
84MP0008875_abnormal_xenobiotic_pharmacok0.73214196
85MP0003718_maternal_effect0.69564404
86MP0000015_abnormal_ear_pigmentation0.68740645
87MP0001545_abnormal_hematopoietic_system0.68705558
88MP0005397_hematopoietic_system_phenotyp0.68705558
89MP0002229_neurodegeneration0.68688255
90MP0002882_abnormal_neuron_morphology0.68094817
91MP0000778_abnormal_nervous_system0.66848901
92MP0003136_yellow_coat_color0.66714357
93MP0003121_genomic_imprinting0.66238309
94MP0004859_abnormal_synaptic_plasticity0.65853924
95MP0002069_abnormal_eating/drinking_beha0.65815794
96MP0002168_other_aberrant_phenotype0.65806880
97MP0002277_abnormal_respiratory_mucosa0.65401463
98MP0006035_abnormal_mitochondrial_morpho0.63626429
99MP0002132_abnormal_respiratory_system0.63280901
100MP0000653_abnormal_sex_gland0.63054063

Predicted human phenotypes

RankGene SetZ-score
1Thyroiditis (HP:0100646)3.48318728
2Amyotrophic lateral sclerosis (HP:0007354)3.47104439
3Severe combined immunodeficiency (HP:0004430)3.46110767
4Medial flaring of the eyebrow (HP:0010747)3.44078281
5Abnormality of midbrain morphology (HP:0002418)3.43318935
6Molar tooth sign on MRI (HP:0002419)3.43318935
7Abnormality of B cell number (HP:0010975)3.38620109
8Absent speech (HP:0001344)3.34159924
9Gait imbalance (HP:0002141)3.32231114
10Pancreatic cysts (HP:0001737)3.29043448
11B lymphocytopenia (HP:0010976)3.20305486
12Congenital primary aphakia (HP:0007707)3.16456074
13Pancreatic fibrosis (HP:0100732)3.15594599
14Nephrogenic diabetes insipidus (HP:0009806)3.12542404
15Hyperventilation (HP:0002883)3.10005007
16Abnormality of the metopic suture (HP:0005556)3.04645074
17Nephronophthisis (HP:0000090)2.91385769
18Tubulointerstitial nephritis (HP:0001970)2.91013540
19Cerebellar dysplasia (HP:0007033)2.85765711
20Abnormality of the labia minora (HP:0012880)2.82310986
21Polyphagia (HP:0002591)2.73261772
22Progressive inability to walk (HP:0002505)2.72316715
23Microvesicular hepatic steatosis (HP:0001414)2.69750583
24True hermaphroditism (HP:0010459)2.68477966
25Combined immunodeficiency (HP:0005387)2.68472473
26Inability to walk (HP:0002540)2.68264786
27Type I transferrin isoform profile (HP:0003642)2.64066146
28Congenital stationary night blindness (HP:0007642)2.63179075
29Focal motor seizures (HP:0011153)2.62003981
30Eosinophilia (HP:0001880)2.52741778
31Abnormality of macular pigmentation (HP:0008002)2.47365689
32Panhypogammaglobulinemia (HP:0003139)2.46719958
33Cystic liver disease (HP:0006706)2.44058697
34Type II lissencephaly (HP:0007260)2.43658806
35Thyroid-stimulating hormone excess (HP:0002925)2.43558319
36Abnormality of the renal medulla (HP:0100957)2.41609945
37Abnormal protein glycosylation (HP:0012346)2.40960494
38Abnormal glycosylation (HP:0012345)2.40960494
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40960494
40Abnormal protein N-linked glycosylation (HP:0012347)2.40960494
41Prominent metopic ridge (HP:0005487)2.40646616
42Focal seizures (HP:0007359)2.39171357
43Failure to thrive in infancy (HP:0001531)2.33257110
44Hepatocellular necrosis (HP:0001404)2.29833013
45Vaginal atresia (HP:0000148)2.26778421
46Genital tract atresia (HP:0001827)2.26739852
47Ketoacidosis (HP:0001993)2.22240700
48Long clavicles (HP:0000890)2.18220436
49Hypoproteinemia (HP:0003075)2.16361940
50Widely spaced teeth (HP:0000687)2.15196225
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.13527756
52Dialeptic seizures (HP:0011146)2.11170380
53Bile duct proliferation (HP:0001408)2.10988177
54Abnormal biliary tract physiology (HP:0012439)2.10988177
55Hypoplasia of the thymus (HP:0000778)2.10696680
56Abnormal rod and cone electroretinograms (HP:0008323)2.10333867
57Abnormality of eosinophils (HP:0001879)2.09001362
58Postaxial hand polydactyly (HP:0001162)2.07806812
59Ketosis (HP:0001946)2.07027045
60Methylmalonic aciduria (HP:0012120)2.05626336
61Hemiparesis (HP:0001269)2.03131158
62Poor coordination (HP:0002370)2.00819004
63Decreased lacrimation (HP:0000633)2.00239747
64Chronic hepatic failure (HP:0100626)1.99976824
65Methylmalonic acidemia (HP:0002912)1.99319197
66Granulocytopenia (HP:0001913)1.99127705
67Occipital encephalocele (HP:0002085)1.98721996
68Retinal dysplasia (HP:0007973)1.98268375
69Hepatic necrosis (HP:0002605)1.98080472
70Narrow forehead (HP:0000341)1.97157713
71Clumsiness (HP:0002312)1.95404572
72Retinitis pigmentosa (HP:0000510)1.94073340
73Hypothermia (HP:0002045)1.93616506
74Entropion (HP:0000621)1.90009046
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89949758
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89949758
77Abnormal respiratory motile cilium morphology (HP:0005938)1.89189027
78Abnormal respiratory epithelium morphology (HP:0012253)1.89189027
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88764159
80Dicarboxylic aciduria (HP:0003215)1.88764159
81Stomach cancer (HP:0012126)1.87867386
82Abnormality of endocrine pancreas physiology (HP:0012093)1.87863581
83Abnormality of the pancreatic islet cells (HP:0006476)1.87863581
84Congenital hepatic fibrosis (HP:0002612)1.86927817
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.84713435
86Facial diplegia (HP:0001349)1.81445042
87Anencephaly (HP:0002323)1.80973199
88Short foot (HP:0001773)1.80520510
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80489140
90Lissencephaly (HP:0001339)1.79561846
91Attenuation of retinal blood vessels (HP:0007843)1.77220678
92Abnormal ciliary motility (HP:0012262)1.76150885
93Hypoplastic pelvis (HP:0008839)1.76004351
94Opisthotonus (HP:0002179)1.75479536
95Abnormality of DNA repair (HP:0003254)1.73847538
96Colon cancer (HP:0003003)1.73091552
97Neurodegeneration (HP:0002180)1.73034201
98Median cleft lip (HP:0000161)1.73026419
99Hypoglycemic seizures (HP:0002173)1.72599893
100Erythroderma (HP:0001019)1.72167185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.93700734
2MAP4K24.03090474
3FRK3.87470329
4CASK3.17575159
5TAOK33.08375159
6MAPK132.95748561
7MARK12.77785171
8WNK32.66692811
9MARK32.35078690
10NUAK12.08643722
11MAP2K72.07184510
12MAP3K41.79703647
13ZAK1.74372017
14BMPR1B1.56166520
15BCKDK1.45868912
16FLT31.43281519
17ADRBK21.39912384
18CSNK1A1L1.34016574
19DYRK31.33688381
20EIF2AK31.26890132
21PTK2B1.25558249
22TRIM281.23334409
23STK38L1.19941495
24BCR1.19342437
25KSR11.19051033
26TNK21.15409049
27CSNK1G31.12987723
28PDK21.10334815
29TXK1.07739138
30INSRR1.03165217
31KIT1.02834068
32RPS6KA41.01202628
33DYRK21.00263034
34GRK70.98102626
35LATS10.96797449
36CSNK1G10.95903588
37MAP3K50.95401241
38BRD40.93332846
39PAK60.86840704
40OBSCN0.85248702
41IKBKB0.82674450
42PLK20.78699236
43PAK30.78682348
44CSNK1G20.78184797
45GRK10.76363395
46ERBB30.74298148
47MAP4K10.73767135
48PKN10.72852054
49SGK20.72069183
50FGFR20.68398267
51DYRK1A0.66484020
52TNIK0.65351497
53SGK4940.64879926
54SGK2230.64879926
55SRPK10.62043610
56OXSR10.61663701
57RPS6KA50.61249746
58CDK30.61241411
59CAMKK20.60972610
60PNCK0.60661740
61PRKCE0.60222935
62MAPK150.60100447
63MAP2K40.58832457
64FGR0.55076438
65PRKCG0.54567535
66PRKCQ0.54244302
67PIM20.53703484
68TGFBR10.52882934
69PRKAA20.52468181
70RPS6KB10.52047423
71SIK20.48269844
72CSF1R0.47140143
73CLK10.47013355
74PRKCZ0.44055912
75PIM10.42768839
76CSNK1A10.40934489
77DYRK1B0.40579586
78DAPK10.40054678
79STK110.39667613
80PRKCI0.38930639
81BLK0.38107169
82CSNK1D0.37796960
83DAPK20.37248733
84CAMK10.37193137
85CAMK2A0.36166786
86KDR0.35646424
87SYK0.35561765
88PRKD20.35231528
89MINK10.35146080
90MAP3K70.35109494
91LYN0.34139543
92ABL10.34032549
93PRKAA10.33056531
94MKNK10.32406422
95EPHA40.30733867
96PIK3CG0.30577038
97ATM0.29712952
98CDK50.28418730
99PHKG20.28058443
100PHKG10.28058443

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.46838442
2Propanoate metabolism_Homo sapiens_hsa006403.09023848
3Butanoate metabolism_Homo sapiens_hsa006502.99991586
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.78390662
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35411369
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29055723
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27699905
8Non-homologous end-joining_Homo sapiens_hsa034502.21909202
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21154319
10Primary immunodeficiency_Homo sapiens_hsa053402.19568226
11Regulation of autophagy_Homo sapiens_hsa041402.13832623
12Fanconi anemia pathway_Homo sapiens_hsa034602.08641399
13Collecting duct acid secretion_Homo sapiens_hsa049661.92844624
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88791239
15Basal transcription factors_Homo sapiens_hsa030221.85356059
16Nicotine addiction_Homo sapiens_hsa050331.82251033
17Taste transduction_Homo sapiens_hsa047421.70991994
18Fatty acid metabolism_Homo sapiens_hsa012121.60644376
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55360106
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54066684
21Tryptophan metabolism_Homo sapiens_hsa003801.53415497
22Olfactory transduction_Homo sapiens_hsa047401.46774959
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46394417
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46154054
25Other glycan degradation_Homo sapiens_hsa005111.45152646
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.44456676
27Peroxisome_Homo sapiens_hsa041461.43647296
28Fatty acid elongation_Homo sapiens_hsa000621.43040178
29Protein export_Homo sapiens_hsa030601.41353352
30Steroid biosynthesis_Homo sapiens_hsa001001.29918757
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.22872875
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21816715
33Linoleic acid metabolism_Homo sapiens_hsa005911.17233165
34Fatty acid degradation_Homo sapiens_hsa000711.15781969
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14116036
36Ether lipid metabolism_Homo sapiens_hsa005651.13570381
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08176590
38ABC transporters_Homo sapiens_hsa020101.07582673
39Rheumatoid arthritis_Homo sapiens_hsa053231.05849631
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02263944
41Circadian rhythm_Homo sapiens_hsa047100.95034629
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90481536
43GABAergic synapse_Homo sapiens_hsa047270.86318822
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.84653285
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84648154
46Glutamatergic synapse_Homo sapiens_hsa047240.84637899
47Selenocompound metabolism_Homo sapiens_hsa004500.83613609
48RNA degradation_Homo sapiens_hsa030180.83178428
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82724076
50Chemical carcinogenesis_Homo sapiens_hsa052040.80435271
51Circadian entrainment_Homo sapiens_hsa047130.79848682
52Legionellosis_Homo sapiens_hsa051340.77787864
53Morphine addiction_Homo sapiens_hsa050320.75843341
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.75448017
55Sphingolipid metabolism_Homo sapiens_hsa006000.74740472
56Nitrogen metabolism_Homo sapiens_hsa009100.74555328
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74345115
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70430351
59N-Glycan biosynthesis_Homo sapiens_hsa005100.70231311
60One carbon pool by folate_Homo sapiens_hsa006700.68730762
61Type II diabetes mellitus_Homo sapiens_hsa049300.67115036
62Lysosome_Homo sapiens_hsa041420.64169314
63Arachidonic acid metabolism_Homo sapiens_hsa005900.63210029
64Type I diabetes mellitus_Homo sapiens_hsa049400.61807665
65Nucleotide excision repair_Homo sapiens_hsa034200.61469721
66Graft-versus-host disease_Homo sapiens_hsa053320.60303945
67Homologous recombination_Homo sapiens_hsa034400.60028217
68Asthma_Homo sapiens_hsa053100.59964183
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58111560
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55323623
71beta-Alanine metabolism_Homo sapiens_hsa004100.54751802
72Hedgehog signaling pathway_Homo sapiens_hsa043400.54293851
73Glutathione metabolism_Homo sapiens_hsa004800.53356639
74Dopaminergic synapse_Homo sapiens_hsa047280.52226999
75mTOR signaling pathway_Homo sapiens_hsa041500.49877524
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49675429
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48885277
78Lysine degradation_Homo sapiens_hsa003100.48526341
79Calcium signaling pathway_Homo sapiens_hsa040200.48136615
80Caffeine metabolism_Homo sapiens_hsa002320.47877099
81Metabolic pathways_Homo sapiens_hsa011000.46711926
82RNA polymerase_Homo sapiens_hsa030200.45374746
83TGF-beta signaling pathway_Homo sapiens_hsa043500.45173669
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44736468
85Insulin secretion_Homo sapiens_hsa049110.44468865
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.43534234
87Allograft rejection_Homo sapiens_hsa053300.42884597
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.42855921
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41928228
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40965002
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40647879
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.39685970
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39236896
94Carbon metabolism_Homo sapiens_hsa012000.37314797
95Cocaine addiction_Homo sapiens_hsa050300.35977466
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35876553
97Hematopoietic cell lineage_Homo sapiens_hsa046400.34961517
98Synaptic vesicle cycle_Homo sapiens_hsa047210.34492931
99Pertussis_Homo sapiens_hsa051330.34458000
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34416035

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