PPIB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.57847960
2SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45347450
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.41402855
4cotranslational protein targeting to membrane (GO:0006613)4.40828440
5protein targeting to ER (GO:0045047)4.39555934
6ribosomal small subunit assembly (GO:0000028)4.30149794
7signal peptide processing (GO:0006465)4.24693559
8protein retention in ER lumen (GO:0006621)4.18650029
9protein localization to endoplasmic reticulum (GO:0070972)4.18520814
10GDP-mannose metabolic process (GO:0019673)4.16426895
11viral transcription (GO:0019083)4.15812909
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15441430
13translational termination (GO:0006415)4.00068149
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.84822432
15ribosomal small subunit biogenesis (GO:0042274)3.67898665
16Golgi transport vesicle coating (GO:0048200)3.67876385
17COPI coating of Golgi vesicle (GO:0048205)3.67876385
18nucleotide-sugar biosynthetic process (GO:0009226)3.59314805
19aldehyde catabolic process (GO:0046185)3.56114908
20activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.53705313
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41219315
22L-phenylalanine catabolic process (GO:0006559)3.41219315
23translational elongation (GO:0006414)3.39661803
24pinocytosis (GO:0006907)3.37926082
25nucleobase-containing small molecule interconversion (GO:0015949)3.31367014
26protein N-linked glycosylation via asparagine (GO:0018279)3.31061907
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.27240961
28L-phenylalanine metabolic process (GO:0006558)3.27240961
29peptidyl-asparagine modification (GO:0018196)3.26007705
30protein hydroxylation (GO:0018126)3.17419220
31regulation of nuclease activity (GO:0032069)3.16850351
32viral life cycle (GO:0019058)3.14975747
33protein N-linked glycosylation (GO:0006487)3.14898572
34hyaluronan catabolic process (GO:0030214)3.14029035
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13070751
36cell adhesion mediated by integrin (GO:0033627)3.12308693
37cellular response to unfolded protein (GO:0034620)3.04724962
38glyoxylate metabolic process (GO:0046487)3.02795478
39vesicle coating (GO:0006901)3.02383764
40pentose-phosphate shunt (GO:0006098)3.00556166
41protein targeting to membrane (GO:0006612)2.99483672
42ER-nucleus signaling pathway (GO:0006984)2.95878052
43peptidyl-glutamic acid carboxylation (GO:0017187)2.95462380
44protein carboxylation (GO:0018214)2.95462380
45intestinal cholesterol absorption (GO:0030299)2.94472449
46L-serine metabolic process (GO:0006563)2.93224990
47serine family amino acid biosynthetic process (GO:0009070)2.92666047
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.92093164
49cellular protein complex disassembly (GO:0043624)2.86296303
50nuclear envelope reassembly (GO:0031468)2.85843253
51mitotic nuclear envelope reassembly (GO:0007084)2.85843253
52regulation of cellular amino acid metabolic process (GO:0006521)2.85513795
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85122274
54translational initiation (GO:0006413)2.83105857
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82545665
56proteasome assembly (GO:0043248)2.81802995
57cellular response to topologically incorrect protein (GO:0035967)2.80919172
58exocrine pancreas development (GO:0031017)2.79716054
59apoptotic cell clearance (GO:0043277)2.78796939
60maturation of SSU-rRNA (GO:0030490)2.77245788
61regulation of metalloenzyme activity (GO:0048552)2.76844669
62endodermal cell differentiation (GO:0035987)2.74309055
63cell redox homeostasis (GO:0045454)2.73632738
64translation (GO:0006412)2.70458829
65positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.68394521
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67065313
67fatty acid elongation (GO:0030497)2.66761169
684-hydroxyproline metabolic process (GO:0019471)2.65697226
69sulfur amino acid catabolic process (GO:0000098)2.64686111
70regulation of plasminogen activation (GO:0010755)2.64609722
71glucose catabolic process (GO:0006007)2.64453722
72regulation of extracellular matrix disassembly (GO:0010715)2.63790239
73ER overload response (GO:0006983)2.63392963
74nucleotide transmembrane transport (GO:1901679)2.62205230
75positive regulation of extracellular matrix organization (GO:1903055)2.62165969
76establishment of viral latency (GO:0019043)2.61729548
77establishment of integrated proviral latency (GO:0075713)2.61314048
78aromatic amino acid family catabolic process (GO:0009074)2.60794703
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59474849
80negative regulation of ligase activity (GO:0051352)2.59474849
81extracellular fibril organization (GO:0043206)2.57197143
82negative regulation of fibrinolysis (GO:0051918)2.56442283
83purine ribonucleotide transport (GO:0015868)2.54903415
84regulation of translational fidelity (GO:0006450)2.52032854
85response to endoplasmic reticulum stress (GO:0034976)2.51977238
86keratan sulfate catabolic process (GO:0042340)2.51941981
87fibrinolysis (GO:0042730)2.51697980
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51292895
89formation of translation preinitiation complex (GO:0001731)2.50544355
90ribosome assembly (GO:0042255)2.49877674
91regulation of protein activation cascade (GO:2000257)2.48496261
92glutamine family amino acid biosynthetic process (GO:0009084)2.48445347
93regulation of fibrinolysis (GO:0051917)2.48117018
94collagen fibril organization (GO:0030199)2.47621879
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47611277
96chondrocyte proliferation (GO:0035988)2.47180274
97cysteine metabolic process (GO:0006534)2.46387812
98response to unfolded protein (GO:0006986)2.45263809
99regulation of cholesterol esterification (GO:0010872)2.44625775
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43831715
101regulation of complement activation (GO:0030449)2.43299006
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43268107
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42937623
104signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42937623
105proline biosynthetic process (GO:0006561)2.40764891
106COPII vesicle coating (GO:0048208)2.40619479
107amyloid precursor protein catabolic process (GO:0042987)2.40221304
108barbed-end actin filament capping (GO:0051016)2.38245679
109hemidesmosome assembly (GO:0031581)2.37908485
110ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.37741244
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.37282174
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.36930715
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.36930715
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.36930715
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.35345131
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.35345131
117gap junction assembly (GO:0016264)2.34649211
118opsonization (GO:0008228)2.34102635
119bile acid biosynthetic process (GO:0006699)2.32714983
120peptidyl-proline hydroxylation (GO:0019511)2.32695280
121protein complex disassembly (GO:0043241)2.32326440
122response to topologically incorrect protein (GO:0035966)2.31193847
123cholesterol biosynthetic process (GO:0006695)2.30398465
124antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.28674316
125anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.28556194
126membrane raft organization (GO:0031579)2.28379148
127fibril organization (GO:0097435)2.28259036
128membrane protein ectodomain proteolysis (GO:0006509)2.27514265
129* chaperone-mediated protein folding (GO:0061077)2.26967279
130UV protection (GO:0009650)2.26893436
131dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.26171654
132lipopolysaccharide biosynthetic process (GO:0009103)2.26154947
133glucuronate metabolic process (GO:0019585)2.25871619
134uronic acid metabolic process (GO:0006063)2.25871619
135negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.25553122
136complement activation, alternative pathway (GO:0006957)2.25192453
137collagen metabolic process (GO:0032963)2.24601715
138cellular aldehyde metabolic process (GO:0006081)2.23777063
139multicellular organismal catabolic process (GO:0044243)2.22655287
140type B pancreatic cell proliferation (GO:0044342)2.22514289
141transcytosis (GO:0045056)2.21454317
142collagen catabolic process (GO:0030574)2.20316734
143primary alcohol catabolic process (GO:0034310)2.17950433
144ethanol oxidation (GO:0006069)2.16710672
145alpha-linolenic acid metabolic process (GO:0036109)2.16423579
146hydrogen peroxide catabolic process (GO:0042744)2.16073526
147cellular glucuronidation (GO:0052695)2.15951103
148peptide catabolic process (GO:0043171)2.15849888
149skin morphogenesis (GO:0043589)2.15721981
150regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.15485031
151endothelial cell morphogenesis (GO:0001886)2.13353509
152high-density lipoprotein particle remodeling (GO:0034375)2.11854742
153homocysteine metabolic process (GO:0050667)2.11721144
154macromolecular complex disassembly (GO:0032984)2.11480764
155NADPH regeneration (GO:0006740)2.11206378
156multicellular organismal metabolic process (GO:0044236)2.10335243
157pyrimidine-containing compound transmembrane transport (GO:0072531)2.09776351
158branched-chain amino acid catabolic process (GO:0009083)2.07511540
159mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.06295697
160extracellular matrix disassembly (GO:0022617)2.05981212
161ribosomal large subunit biogenesis (GO:0042273)2.05432241
162basement membrane organization (GO:0071711)2.05135627
163valine metabolic process (GO:0006573)2.05088275
164regulation of lipoprotein particle clearance (GO:0010984)2.03385042
165proline metabolic process (GO:0006560)2.03179607
166positive regulation of nuclease activity (GO:0032075)2.03053643
167multicellular organismal macromolecule metabolic process (GO:0044259)2.02771593
168response to nitrosative stress (GO:0051409)2.01640062
169endoplasmic reticulum unfolded protein response (GO:0030968)2.01292713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.61357389
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80228892
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97952933
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.96587245
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.96262315
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.79270315
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77729202
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.77270568
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.75264758
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71739143
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.62176011
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.58496074
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57914673
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38421312
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38018954
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31006591
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30698230
18ZNF263_19887448_ChIP-Seq_K562_Human2.29920649
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.27557964
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26647684
21CLOCK_20551151_ChIP-Seq_293T_Human2.25472402
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20077647
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12240364
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.09933086
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09381733
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.03770755
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.00308185
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87968737
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84753135
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.82305226
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81658028
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77785115
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77062481
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75980795
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73531589
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72004833
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71697991
38ELK1_19687146_ChIP-ChIP_HELA_Human1.64975147
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60689428
40DCP1A_22483619_ChIP-Seq_HELA_Human1.59847362
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57710634
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57501889
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53689079
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51760577
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.50465210
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.49433494
47RACK7_27058665_Chip-Seq_MCF-7_Human1.45824521
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45099890
49XRN2_22483619_ChIP-Seq_HELA_Human1.45026106
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43188065
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41912839
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41017982
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40025021
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39519878
55LXR_22292898_ChIP-Seq_THP-1_Human1.37576441
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36702548
57* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36634921
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36500184
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35732018
60ATF3_27146783_Chip-Seq_COLON_Human1.35464593
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.33704472
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32967212
63AR_21909140_ChIP-Seq_LNCAP_Human1.32508350
64* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.32291169
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32261469
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31037275
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29528551
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.29285016
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28107314
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27622004
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27454638
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27114472
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26956260
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26572637
75* VDR_23849224_ChIP-Seq_CD4+_Human1.23445990
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23436673
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22726978
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22499401
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20163234
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19580340
81VDR_21846776_ChIP-Seq_THP-1_Human1.18424171
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17838659
83* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16377372
84SOX2_20726797_ChIP-Seq_SW620_Human1.16129868
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15845656
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.14840272
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14653838
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13786631
89GATA4_25053715_ChIP-Seq_YYC3_Human1.12262077
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11208207
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10848256
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.09625040
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08660030
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08547688
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08262205
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08025340
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.07471199
98* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06599410
99MYC_22102868_ChIP-Seq_BL_Human1.05122957
100GATA1_22025678_ChIP-Seq_K562_Human1.03686730
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03101852
102* GABP_19822575_ChIP-Seq_HepG2_Human1.02751556
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02285589
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02274067
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99325703
106TTF2_22483619_ChIP-Seq_HELA_Human0.99322422
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99248227
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.99065056
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98709782
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98550762
111SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97897592
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97749213
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97332475
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97141204
115KDM5A_27292631_Chip-Seq_BREAST_Human0.96542951
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95646341
117* SPI1_23547873_ChIP-Seq_NB4_Human0.94779252
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93018766
119TFEB_21752829_ChIP-Seq_HELA_Human0.92366321
120FOXP3_21729870_ChIP-Seq_TREG_Human0.92162113
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91515939
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90583186
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88109832
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.87713023
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87261159
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86278604
127E2F7_22180533_ChIP-Seq_HELA_Human0.85965693
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85890376
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84686205
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84398084
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84272850
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84272850
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84272850
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84174796
135* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83279590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen3.70090122
2MP0003806_abnormal_nucleotide_metabolis3.33445049
3MP0005083_abnormal_biliary_tract2.90706676
4MP0002139_abnormal_hepatobiliary_system2.86240018
5MP0006054_spinal_hemorrhage2.82320235
6MP0005257_abnormal_intraocular_pressure2.80943438
7MP0005503_abnormal_tendon_morphology2.79425244
8MP0001666_abnormal_nutrient_absorption2.56405400
9MP0005275_abnormal_skin_tensile2.45635941
10MP0005360_urolithiasis2.44299869
11MP0005365_abnormal_bile_salt2.42037968
12MP0005085_abnormal_gallbladder_physiolo2.32755304
13MP0003705_abnormal_hypodermis_morpholog2.20970187
14MP0004272_abnormal_basement_membrane2.06412945
15MP0009384_cardiac_valve_regurgitation1.97797086
16MP0002877_abnormal_melanocyte_morpholog1.95745500
17MP0003186_abnormal_redox_activity1.94185399
18MP0005408_hypopigmentation1.89115897
19MP0005220_abnormal_exocrine_pancreas1.81255284
20MP0003941_abnormal_skin_development1.78073020
21MP0003950_abnormal_plasma_membrane1.70090645
22MP0010234_abnormal_vibrissa_follicle1.63384281
23MP0009379_abnormal_foot_pigmentation1.61252055
24MP0003279_aneurysm1.59303775
25MP0002933_joint_inflammation1.58333786
26MP0001958_emphysema1.56135658
27MP0004858_abnormal_nervous_system1.54068524
28MP0001542_abnormal_bone_strength1.52615616
29MP0005023_abnormal_wound_healing1.47239328
30MP0002295_abnormal_pulmonary_circulatio1.44692170
31MP0002282_abnormal_trachea_morphology1.39933580
32MP0001849_ear_inflammation1.36857337
33MP0004134_abnormal_chest_morphology1.35872597
34MP0005623_abnormal_meninges_morphology1.33102923
35MP0005058_abnormal_lysosome_morphology1.31075009
36MP0005084_abnormal_gallbladder_morpholo1.30907834
37MP0008260_abnormal_autophagy1.30506162
38MP0008007_abnormal_cellular_replicative1.29588845
39MP0001243_abnormal_dermal_layer1.28041105
40MP0008875_abnormal_xenobiotic_pharmacok1.26681752
41MP0009840_abnormal_foam_cell1.24427138
42MP0003091_abnormal_cell_migration1.21643592
43MP0005165_increased_susceptibility_to1.20462962
44* MP0002060_abnormal_skin_morphology1.19871366
45MP0005508_abnormal_skeleton_morphology1.18827568
46MP0005332_abnormal_amino_acid1.17906408
47MP0001533_abnormal_skeleton_physiology1.17900352
48MP0001661_extended_life_span1.16593267
49MP0003252_abnormal_bile_duct1.14674944
50MP0010352_gastrointestinal_tract_polyps1.13694506
51MP0003436_decreased_susceptibility_to1.13114875
52MP0003195_calcinosis1.12620578
53MP0009053_abnormal_anal_canal1.11858407
54MP0003693_abnormal_embryo_hatching1.09138475
55MP0009643_abnormal_urine_homeostasis1.09115118
56MP0005451_abnormal_body_composition1.09050346
57MP0003191_abnormal_cellular_cholesterol1.07969239
58MP0008932_abnormal_embryonic_tissue1.07288107
59MP0000537_abnormal_urethra_morphology1.06709203
60MP0003566_abnormal_cell_adhesion1.05992949
61MP0005390_skeleton_phenotype1.05501851
62MP0005501_abnormal_skin_physiology1.04082203
63MP0009333_abnormal_splenocyte_physiolog1.01715333
64MP0002796_impaired_skin_barrier1.00977365
65MP0005164_abnormal_response_to1.00949958
66MP0010030_abnormal_orbit_morphology1.00371427
67MP0009250_abnormal_appendicular_skeleto1.00042113
68MP0003448_altered_tumor_morphology0.99765721
69MP0003868_abnormal_feces_composition0.99694600
70MP0001881_abnormal_mammary_gland0.99554400
71MP0002254_reproductive_system_inflammat0.99437023
72MP0003172_abnormal_lysosome_physiology0.98840528
73MP0000163_abnormal_cartilage_morphology0.98612468
74MP0004233_abnormal_muscle_weight0.98455348
75MP0003011_delayed_dark_adaptation0.98174426
76MP0010368_abnormal_lymphatic_system0.97734953
77MP0003786_premature_aging0.97117875
78MP0010329_abnormal_lipoprotein_level0.95917932
79MP0000685_abnormal_immune_system0.94819463
80MP0001835_abnormal_antigen_presentation0.94191834
81MP0004782_abnormal_surfactant_physiolog0.93903873
82MP0009785_altered_susceptibility_to0.93735165
83MP0005197_abnormal_uvea_morphology0.92027601
84MP0000358_abnormal_cell_content/0.90590719
85MP0002148_abnormal_hypersensitivity_rea0.89930881
86MP0003453_abnormal_keratinocyte_physiol0.88900044
87MP0003111_abnormal_nucleus_morphology0.88324037
88MP0001216_abnormal_epidermal_layer0.87853352
89MP0002115_abnormal_skeleton_extremities0.87275912
90MP0006082_CNS_inflammation0.86774521
91MP0000343_altered_response_to0.85788333
92MP0000003_abnormal_adipose_tissue0.85594717
93MP0005171_absent_coat_pigmentation0.84237560
94MP0001730_embryonic_growth_arrest0.83773701
95MP0003075_altered_response_to0.83376499
96MP0003724_increased_susceptibility_to0.83095968
97MP0004264_abnormal_extraembryonic_tissu0.82913226
98MP0008469_abnormal_protein_level0.82724693
99MP0000604_amyloidosis0.82030843
100MP0001915_intracranial_hemorrhage0.81414653
101* MP0003795_abnormal_bone_structure0.81371408
102MP0002113_abnormal_skeleton_development0.81222289
103MP0002896_abnormal_bone_mineralization0.81203826
104MP0002419_abnormal_innate_immunity0.80706587
105MP0001879_abnormal_lymphatic_vessel0.80328253
106MP0000465_gastrointestinal_hemorrhage0.79664930
107MP0000609_abnormal_liver_physiology0.79622251
108MP0000598_abnormal_liver_morphology0.79313548
109MP0000858_altered_metastatic_potential0.79142755
110MP0000762_abnormal_tongue_morphology0.78886572
111MP0005330_cardiomyopathy0.78707180
112MP0005076_abnormal_cell_differentiation0.78000683
113MP0005621_abnormal_cell_physiology0.77537136
114MP0002138_abnormal_hepatobiliary_system0.77531418
115MP0001873_stomach_inflammation0.76625273
116MP0005025_abnormal_response_to0.76576584
117MP0003300_gastrointestinal_ulcer0.76417395
118MP0002938_white_spotting0.76409434
119MP0005319_abnormal_enzyme/_coenzyme0.76080519
120MP0001845_abnormal_inflammatory_respons0.75851131
121MP0009697_abnormal_copulation0.75839365
122MP0008004_abnormal_stomach_pH0.75799705
123MP0000383_abnormal_hair_follicle0.75572561
124MP0002098_abnormal_vibrissa_morphology0.75398046
125MP0002089_abnormal_postnatal_growth/wei0.74645969
126MP0000767_abnormal_smooth_muscle0.73590093
127MP0000490_abnormal_crypts_of0.73245553
128MP0001853_heart_inflammation0.73178782
129MP0000627_abnormal_mammary_gland0.71839833
130MP0010678_abnormal_skin_adnexa0.71103017
131MP0002166_altered_tumor_susceptibility0.70057329
132MP0002405_respiratory_system_inflammati0.69308084
133MP0003942_abnormal_urinary_system0.69090981
134MP0000350_abnormal_cell_proliferation0.68787958
135MP0010155_abnormal_intestine_physiology0.68542459
136MP0000467_abnormal_esophagus_morphology0.68507098
137MP0005384_cellular_phenotype0.68506448
138MP0002136_abnormal_kidney_physiology0.67594040
139MP0009763_increased_sensitivity_to0.67110248
140MP0004957_abnormal_blastocyst_morpholog0.67101630
141MP0005464_abnormal_platelet_physiology0.66685127
142MP0003656_abnormal_erythrocyte_physiolo0.66625582
143MP0002080_prenatal_lethality0.66278909
144MP0005193_abnormal_anterior_eye0.65616032
145MP0002396_abnormal_hematopoietic_system0.65481405
146MP0000377_abnormal_hair_follicle0.65245600
147MP0002132_abnormal_respiratory_system0.65154025
148* MP0009931_abnormal_skin_appearance0.64045426
149MP0001348_abnormal_lacrimal_gland0.63712876
150* MP0010771_integument_phenotype0.61893482

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)3.99965833
2Premature rupture of membranes (HP:0001788)3.66842956
3Protrusio acetabuli (HP:0003179)3.55544240
4Abnormal tarsal ossification (HP:0008369)3.37166363
5Abnormality of cells of the erythroid lineage (HP:0012130)3.23450477
6Abnormal number of erythroid precursors (HP:0012131)2.90451024
7Abnormal foot bone ossification (HP:0010675)2.88789722
8Beaking of vertebral bodies (HP:0004568)2.87404293
9Deep venous thrombosis (HP:0002625)2.86532238
10Abnormality of glycolipid metabolism (HP:0010969)2.86403380
11Abnormality of liposaccharide metabolism (HP:0010968)2.86403380
12Abnormality of glycosphingolipid metabolism (HP:0004343)2.86403380
13Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86208153
14Irregular epiphyses (HP:0010582)2.82391120
15Fragile skin (HP:0001030)2.81090242
16Steatorrhea (HP:0002570)2.81071459
17Small epiphyses (HP:0010585)2.79512906
18Intrahepatic cholestasis (HP:0001406)2.78514655
19Cholecystitis (HP:0001082)2.74464546
20Abnormal gallbladder physiology (HP:0012438)2.74464546
21Vacuolated lymphocytes (HP:0001922)2.71186087
22Cervical subluxation (HP:0003308)2.68467068
23Elbow flexion contracture (HP:0002987)2.65531131
24Fat malabsorption (HP:0002630)2.64782972
25Abnormality of the intrinsic pathway (HP:0010989)2.62805299
26Hypobetalipoproteinemia (HP:0003563)2.56277337
27Bladder diverticulum (HP:0000015)2.52935373
28Cupped ribs (HP:0000887)2.51811677
29Trismus (HP:0000211)2.48690710
30Abnormality of the common coagulation pathway (HP:0010990)2.48322257
31Nonimmune hydrops fetalis (HP:0001790)2.46459104
32Aortic dissection (HP:0002647)2.46392833
33Vitreoretinal degeneration (HP:0000655)2.45392668
34Abnormal cartilage morphology (HP:0002763)2.41503030
35Vascular tortuosity (HP:0004948)2.41342515
36Peritonitis (HP:0002586)2.41245985
37Neonatal short-limb short stature (HP:0008921)2.41069006
38Prolonged partial thromboplastin time (HP:0003645)2.40806344
39Type I transferrin isoform profile (HP:0003642)2.39633849
40Vertebral compression fractures (HP:0002953)2.38941185
41Rough bone trabeculation (HP:0100670)2.38765696
42Short nail (HP:0001799)2.34483557
43Abnormality of the Achilles tendon (HP:0005109)2.33590456
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33450778
45Biconcave vertebral bodies (HP:0004586)2.31909073
46Achilles tendon contracture (HP:0001771)2.31452208
47Systemic lupus erythematosus (HP:0002725)2.30939874
48Platyspondyly (HP:0000926)2.30079461
49Reticulocytopenia (HP:0001896)2.29953924
50Spondylolisthesis (HP:0003302)2.29804877
51Soft skin (HP:0000977)2.27931048
52* Abnormality of dentin (HP:0010299)2.25412490
53Osteolytic defects of the hand bones (HP:0009699)2.24951404
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.24951404
55Metaphyseal dysplasia (HP:0100255)2.24832810
56Abnormality of carpal bone ossification (HP:0006257)2.24750603
57Generalized amyotrophy (HP:0003700)2.24364794
58Cerebral aneurysm (HP:0004944)2.18464315
59Back pain (HP:0003418)2.18197183
60Arterial tortuosity (HP:0005116)2.16217179
61Complement deficiency (HP:0004431)2.15060144
62Glossoptosis (HP:0000162)2.14742929
63Xanthomatosis (HP:0000991)2.14445786
64Dysostosis multiplex (HP:0000943)2.13933314
65Nuclear cataract (HP:0100018)2.13362567
66Hypokinesia (HP:0002375)2.10140662
67Orthostatic hypotension (HP:0001278)2.08745140
68Dilatation of the ascending aorta (HP:0005111)2.08254613
69Distal upper limb amyotrophy (HP:0007149)2.07489483
70Upper limb amyotrophy (HP:0009129)2.07489483
71Delayed epiphyseal ossification (HP:0002663)2.05645769
72Osteoarthritis (HP:0002758)2.05626922
73Abnormality of the umbilical cord (HP:0010881)2.04158203
74Mitral stenosis (HP:0001718)2.03017379
75Atrophic scars (HP:0001075)2.01045414
76* Blue sclerae (HP:0000592)1.98634161
77Hand muscle atrophy (HP:0009130)1.97958127
78Premature skin wrinkling (HP:0100678)1.97266732
79Joint stiffness (HP:0001387)1.97248391
80Metaphyseal cupping (HP:0003021)1.97050099
81Microvesicular hepatic steatosis (HP:0001414)1.96834968
82Macrocytic anemia (HP:0001972)1.96596589
83Urinary glycosaminoglycan excretion (HP:0003541)1.96494316
84Mucopolysacchariduria (HP:0008155)1.96494316
85Flat acetabular roof (HP:0003180)1.95928691
86Abnormality of the lumbar spine (HP:0100712)1.95492267
87Spinal rigidity (HP:0003306)1.93695910
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91119132
89Genu recurvatum (HP:0002816)1.91012642
90Abnormal vertebral ossification (HP:0100569)1.90747603
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90592186
92Abnormality of polysaccharide metabolism (HP:0011012)1.90592186
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90592186
94Abnormality of the acetabulum (HP:0003170)1.90420655
95Abnormality of complement system (HP:0005339)1.89476897
96Cardiovascular calcification (HP:0011915)1.88886471
97Abnormal trabecular bone morphology (HP:0100671)1.87550183
98Breech presentation (HP:0001623)1.87335138
99Multiple enchondromatosis (HP:0005701)1.87305053
100J-shaped sella turcica (HP:0002680)1.86940956
101* Wormian bones (HP:0002645)1.86187787
102Ankle contracture (HP:0006466)1.85647494
103Abnormalities of placenta or umbilical cord (HP:0001194)1.84868530
104Prolonged neonatal jaundice (HP:0006579)1.83997405
105Purpura (HP:0000979)1.82351552
106Abnormality of the 2nd finger (HP:0004100)1.82333918
107Ectopia lentis (HP:0001083)1.81816746
108Spinal cord compression (HP:0002176)1.80761735
109Thrombocytosis (HP:0001894)1.80612507
110Aortic aneurysm (HP:0004942)1.80563146
111Shallow orbits (HP:0000586)1.78881652
112Abnormality of methionine metabolism (HP:0010901)1.78609502
113Abnormality of the distal phalanges of the toes (HP:0010182)1.78353141
114Reduced antithrombin III activity (HP:0001976)1.78061123
115Protuberant abdomen (HP:0001538)1.77173269
116Abnormal protein glycosylation (HP:0012346)1.76676331
117Abnormal glycosylation (HP:0012345)1.76676331
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76676331
119Abnormal protein N-linked glycosylation (HP:0012347)1.76676331
120Abnormal ossification of hand bones (HP:0005921)1.75751863
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75175842
122Coxa vara (HP:0002812)1.74335328
123Irregular vertebral endplates (HP:0003301)1.74305035
124Vascular calcification (HP:0004934)1.74300423
125Glucose intolerance (HP:0000833)1.72516224
126Abnormal hemoglobin (HP:0011902)1.72383470
127Abnormality of the vertebral endplates (HP:0005106)1.72333927
128Genu varum (HP:0002970)1.71172392
129Abnormal umbilical cord blood vessels (HP:0011403)1.71054512
130Single umbilical artery (HP:0001195)1.71054512
131Abnormality of the fetal cardiovascular system (HP:0010948)1.71054512
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69803660
133Testicular atrophy (HP:0000029)1.69563724
134Hyperextensible skin (HP:0000974)1.68724477
135Myocardial infarction (HP:0001658)1.68346681
136Respiratory distress (HP:0002098)1.68261990
137Delayed cranial suture closure (HP:0000270)1.67054489
138Hypolipoproteinemia (HP:0010981)1.66573638
139Thin skin (HP:0000963)1.66186759
140Vertebral hypoplasia (HP:0008417)1.66175674
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.66175674
142Thoracolumbar scoliosis (HP:0002944)1.65203635
143Hypoplasia of the odontoid process (HP:0003311)1.64533523
144Abnormality of sulfur amino acid metabolism (HP:0004339)1.63625701
145Abnormal hand bone ossification (HP:0010660)1.63132838
146Opisthotonus (HP:0002179)1.62838519
147Increased serum pyruvate (HP:0003542)1.62749823
148Abnormality of glycolysis (HP:0004366)1.62749823
149Ulnar bowing (HP:0003031)1.60526194
150Barrel-shaped chest (HP:0001552)1.59556005
151Follicular hyperkeratosis (HP:0007502)1.59047571
152Glomerulonephritis (HP:0000099)1.57965778
153Poor head control (HP:0002421)1.57428875
154Stridor (HP:0010307)1.57324456
155Abnormal delivery (HP:0001787)1.56738988
156Ovoid vertebral bodies (HP:0003300)1.55965652
157Abnormality of fatty-acid metabolism (HP:0004359)1.54733815
158Hepatocellular carcinoma (HP:0001402)1.54712904
159Spastic diplegia (HP:0001264)1.54611472
160Flattened epiphyses (HP:0003071)1.53978122
161Joint hemorrhage (HP:0005261)1.52773647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.28813557
2NME23.28150318
3ERN13.23952450
4BCKDK3.04331920
5MST42.68613923
6PBK2.52733050
7SMG12.28203950
8MAP3K122.10174760
9EIF2AK32.05871597
10LRRK21.95290137
11MAP3K31.93153759
12TRIB31.88032990
13KDR1.84768070
14DDR21.81925373
15ARAF1.80980450
16PIM21.80415571
17MET1.79160165
18PDK21.77314788
19LIMK11.71766202
20NEK11.64044889
21TESK11.57593734
22STK391.52598290
23TGFBR11.51312084
24TESK21.50266526
25PKN21.49644697
26EPHB11.47844380
27MYLK1.47122195
28ILK1.43914348
29RPS6KB21.39693272
30SIK11.38004238
31MST1R1.35461000
32EIF2AK11.32703188
33BLK1.31098977
34TBK11.29904966
35PAK41.28172938
36NEK91.23987893
37BUB11.23600977
38RPS6KA41.19550400
39MAP2K21.15792345
40EEF2K1.14888075
41TRPM71.14687174
42EPHA21.14511545
43PIK3CG1.11277250
44TGFBR21.11170202
45IRAK41.10941265
46TYK21.10357314
47LMTK21.10105468
48FGFR41.08553604
49TAOK21.06584360
50STK101.03320376
51STK161.02402332
52PAK21.01612088
53PASK0.98733620
54LATS20.94814898
55ZAP700.94148917
56MAP3K140.93797314
57FLT30.92269710
58NUAK10.91581013
59MOS0.91482316
60ICK0.91074625
61ACVR1B0.90976062
62PTK60.90938951
63FRK0.90116420
64CDK80.86910403
65SRPK10.86782074
66NTRK10.86767424
67MAP2K30.86745760
68ABL20.84572601
69DAPK10.83661092
70DAPK30.83642557
71TSSK60.82272653
72LATS10.80287573
73SCYL20.77518370
74BMPR1B0.74742736
75MAP4K10.73406078
76IKBKB0.72129311
77TTK0.71748442
78BTK0.71608448
79VRK10.69124252
80NME10.69055328
81CSF1R0.68755539
82EPHB20.68689471
83MAP3K80.68190191
84STK30.67887056
85PRPF4B0.67105248
86EPHA30.66545612
87MAPKAPK30.62220895
88KIT0.61802617
89BRSK10.61432505
90AURKA0.61137189
91WNK40.61117987
92PTK20.60788074
93PDGFRA0.60021351
94IKBKE0.58647692
95JAK30.58068146
96STK38L0.57850198
97IRAK30.57679561
98PRKG20.57336415
99BCR0.56962092
100PDGFRB0.56598909
101CSK0.56071819
102PIM10.55798871
103ERBB30.55422327
104FGFR20.52968337
105ITK0.52908970
106ERBB40.50499432
107STK240.50154951
108PAK10.49747944
109MAPK110.49021526
110BMX0.48764305
111AURKB0.48457273
112CLK10.48120553
113CDK70.47937634
114LYN0.46796759
115STK40.46702263
116TTN0.46416029
117BRAF0.46119895
118CHUK0.45879660
119RPS6KA50.45637097
120PIK3CA0.45297940
121MKNK10.44743128
122MAP3K100.44253931
123MAPKAPK20.43443743
124DYRK20.43127816
125PRKCI0.42432593
126ROCK20.41673842
127MTOR0.41435418
128GSK3A0.41290374
129WEE10.39347798
130PRKD20.38868700
131FER0.37193244
132RIPK10.36060556
133CDK60.35591860
134CDK40.32679973
135CSNK2A20.32109229
136AKT20.30777611
137CHEK20.27632362
138RAF10.27304148
139CSNK2A10.26881964
140MAPKAPK50.25106685
141EIF2AK20.25047228
142CDK90.23850398

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.61560942
2Ribosome_Homo sapiens_hsa030103.06985938
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.85311196
4Proteasome_Homo sapiens_hsa030502.38803300
5Steroid biosynthesis_Homo sapiens_hsa001002.16336039
6Fructose and mannose metabolism_Homo sapiens_hsa000512.10776100
7Sulfur metabolism_Homo sapiens_hsa009202.02539458
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.02163422
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95679805
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90594526
11Folate biosynthesis_Homo sapiens_hsa007901.75861636
12Vibrio cholerae infection_Homo sapiens_hsa051101.75037134
13Complement and coagulation cascades_Homo sapiens_hsa046101.72571744
14Fatty acid elongation_Homo sapiens_hsa000621.69805589
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61113908
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59433873
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58555752
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53421557
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53347824
20Glutathione metabolism_Homo sapiens_hsa004801.52905019
21Protein digestion and absorption_Homo sapiens_hsa049741.51254141
22Histidine metabolism_Homo sapiens_hsa003401.50581397
23Fat digestion and absorption_Homo sapiens_hsa049751.50504965
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45358814
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40814130
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40572056
27Chemical carcinogenesis_Homo sapiens_hsa052041.40225806
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38398878
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37252874
30ECM-receptor interaction_Homo sapiens_hsa045121.32890921
31One carbon pool by folate_Homo sapiens_hsa006701.31824760
32Fatty acid degradation_Homo sapiens_hsa000711.31630847
33Selenocompound metabolism_Homo sapiens_hsa004501.30991363
34Staphylococcus aureus infection_Homo sapiens_hsa051501.30388321
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26419762
36Peroxisome_Homo sapiens_hsa041461.22145729
37Tryptophan metabolism_Homo sapiens_hsa003801.21351087
38Other glycan degradation_Homo sapiens_hsa005111.18616292
39Arginine and proline metabolism_Homo sapiens_hsa003301.18452389
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.16947513
41Caffeine metabolism_Homo sapiens_hsa002321.16422515
42Prion diseases_Homo sapiens_hsa050201.14979890
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11274078
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07012861
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05301549
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.04921717
47Propanoate metabolism_Homo sapiens_hsa006401.04701934
48N-Glycan biosynthesis_Homo sapiens_hsa005101.04082297
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.02658860
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.00231313
51Vitamin digestion and absorption_Homo sapiens_hsa049770.99798664
52DNA replication_Homo sapiens_hsa030300.99657909
53Bladder cancer_Homo sapiens_hsa052190.99159106
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98258274
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97796645
56Vitamin B6 metabolism_Homo sapiens_hsa007500.97707337
57Oxidative phosphorylation_Homo sapiens_hsa001900.97466189
58RNA polymerase_Homo sapiens_hsa030200.97185234
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94229189
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94120553
61Retinol metabolism_Homo sapiens_hsa008300.93523615
62Tyrosine metabolism_Homo sapiens_hsa003500.93247731
63Sulfur relay system_Homo sapiens_hsa041220.91351230
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.90823940
65Arachidonic acid metabolism_Homo sapiens_hsa005900.85869031
66Pyrimidine metabolism_Homo sapiens_hsa002400.85554803
67Fatty acid metabolism_Homo sapiens_hsa012120.83670564
68Malaria_Homo sapiens_hsa051440.82606916
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80307675
70Shigellosis_Homo sapiens_hsa051310.79627578
71beta-Alanine metabolism_Homo sapiens_hsa004100.78520124
72Phenylalanine metabolism_Homo sapiens_hsa003600.78355893
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76954527
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76122261
75Antigen processing and presentation_Homo sapiens_hsa046120.75432079
76Parkinsons disease_Homo sapiens_hsa050120.74962260
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74912015
78Lysosome_Homo sapiens_hsa041420.71228324
79Legionellosis_Homo sapiens_hsa051340.69192385
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68877881
81Starch and sucrose metabolism_Homo sapiens_hsa005000.66937072
82Pyruvate metabolism_Homo sapiens_hsa006200.66841601
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66802161
84Biosynthesis of amino acids_Homo sapiens_hsa012300.66676274
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.66220528
86PPAR signaling pathway_Homo sapiens_hsa033200.64143335
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62027888
88Metabolic pathways_Homo sapiens_hsa011000.60706002
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58636241
90Alzheimers disease_Homo sapiens_hsa050100.58626897
91Proteoglycans in cancer_Homo sapiens_hsa052050.58565078
92Huntingtons disease_Homo sapiens_hsa050160.57580951
93Amoebiasis_Homo sapiens_hsa051460.57572529
94Nucleotide excision repair_Homo sapiens_hsa034200.57568891
95Linoleic acid metabolism_Homo sapiens_hsa005910.57244483
96Spliceosome_Homo sapiens_hsa030400.56362796
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56179850
98RNA transport_Homo sapiens_hsa030130.56140416
99Arginine biosynthesis_Homo sapiens_hsa002200.55608932
100Mismatch repair_Homo sapiens_hsa034300.55603256
101Renin-angiotensin system_Homo sapiens_hsa046140.53487678
102Carbon metabolism_Homo sapiens_hsa012000.53220853
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.53061152
104Pentose phosphate pathway_Homo sapiens_hsa000300.51691475
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49591444
106Thyroid cancer_Homo sapiens_hsa052160.47934369
107Small cell lung cancer_Homo sapiens_hsa052220.47686083
108Autoimmune thyroid disease_Homo sapiens_hsa053200.47223609
109Phagosome_Homo sapiens_hsa041450.46990065
110Sphingolipid metabolism_Homo sapiens_hsa006000.46980048
111Systemic lupus erythematosus_Homo sapiens_hsa053220.46758732
112Base excision repair_Homo sapiens_hsa034100.46211233
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45061713
114Pancreatic secretion_Homo sapiens_hsa049720.45032487
115Butanoate metabolism_Homo sapiens_hsa006500.42558339
116TGF-beta signaling pathway_Homo sapiens_hsa043500.41243538
117Focal adhesion_Homo sapiens_hsa045100.39981431
118Pertussis_Homo sapiens_hsa051330.39808559
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39446218
120Apoptosis_Homo sapiens_hsa042100.39093570
121p53 signaling pathway_Homo sapiens_hsa041150.38788371
122Salmonella infection_Homo sapiens_hsa051320.38332742
123Galactose metabolism_Homo sapiens_hsa000520.36369187
124Ether lipid metabolism_Homo sapiens_hsa005650.34852798
125Purine metabolism_Homo sapiens_hsa002300.33640875
126Thyroid hormone synthesis_Homo sapiens_hsa049180.33636388
127Mineral absorption_Homo sapiens_hsa049780.28279834

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