PPIAP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.24320136
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.17699273
3cytidine deamination (GO:0009972)6.14629457
4cytidine metabolic process (GO:0046087)6.14629457
5cytidine catabolic process (GO:0006216)6.14629457
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.62516751
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.55023728
8ATP synthesis coupled proton transport (GO:0015986)5.30611051
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30611051
10sequestering of actin monomers (GO:0042989)4.92932624
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.47324189
12respiratory electron transport chain (GO:0022904)4.39647241
13electron transport chain (GO:0022900)4.33726048
14regulation of cellular amino acid metabolic process (GO:0006521)4.31554047
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26786046
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.19041450
17ribosomal small subunit assembly (GO:0000028)4.16703257
18signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.07147931
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.07147931
20signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.07147931
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.06769118
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.06769118
23water-soluble vitamin biosynthetic process (GO:0042364)3.98782005
24proteasome assembly (GO:0043248)3.97346078
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93542352
26protein deneddylation (GO:0000338)3.86942443
27signal transduction involved in DNA integrity checkpoint (GO:0072401)3.86188295
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.86188295
29signal transduction involved in cell cycle checkpoint (GO:0072395)3.81414885
30protein neddylation (GO:0045116)3.80121063
31negative regulation of ligase activity (GO:0051352)3.79704698
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.79704698
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.78312147
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78295599
35chaperone-mediated protein transport (GO:0072321)3.73712603
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.70903742
37cullin deneddylation (GO:0010388)3.67737385
38protein complex biogenesis (GO:0070271)3.65281237
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.62373512
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.57881627
41termination of RNA polymerase III transcription (GO:0006386)3.57881627
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54173133
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52634794
44antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.47450687
45ubiquinone biosynthetic process (GO:0006744)3.43850228
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.43577210
47NADH dehydrogenase complex assembly (GO:0010257)3.43577210
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43577210
49mitochondrial respiratory chain complex assembly (GO:0033108)3.40471210
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38345901
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36868724
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32373375
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32373375
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25411814
55actin nucleation (GO:0045010)3.24597430
56base-excision repair, AP site formation (GO:0006285)3.23587824
57platelet dense granule organization (GO:0060155)3.22108465
58deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.19814163
59positive regulation of ligase activity (GO:0051351)3.18285068
60regulation of cellular amine metabolic process (GO:0033238)3.13730021
61pyrimidine nucleoside catabolic process (GO:0046135)3.12750860
62DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.12132670
63ubiquinone metabolic process (GO:0006743)3.08535713
64hydrogen ion transmembrane transport (GO:1902600)3.08184676
65regulation of chronic inflammatory response (GO:0002676)3.05708197
66positive regulation of cell cycle arrest (GO:0071158)3.03364798
67iron-sulfur cluster assembly (GO:0016226)2.94133324
68metallo-sulfur cluster assembly (GO:0031163)2.94133324
69ATP biosynthetic process (GO:0006754)2.89646538
70proton transport (GO:0015992)2.88403502
71protein peptidyl-prolyl isomerization (GO:0000413)2.85738976
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85240962
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.84401563
74quinone biosynthetic process (GO:1901663)2.83970924
75respiratory chain complex IV assembly (GO:0008535)2.82625323
76regulation of ubiquitin-protein transferase activity (GO:0051438)2.82438993
77behavioral response to nicotine (GO:0035095)2.82348738
78purine deoxyribonucleotide catabolic process (GO:0009155)2.81597568
79hydrogen transport (GO:0006818)2.81297565
80positive regulation of prostaglandin secretion (GO:0032308)2.80553694
81mannosylation (GO:0097502)2.76678067
82cytolysis (GO:0019835)2.74653997
83response to interferon-beta (GO:0035456)2.74077291
84protein targeting to mitochondrion (GO:0006626)2.72831150
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.70771493
86aldehyde catabolic process (GO:0046185)2.70109734
87deoxyribonucleotide catabolic process (GO:0009264)2.69711719
88regulation of ligase activity (GO:0051340)2.69177646
89regulation of mitochondrial translation (GO:0070129)2.68765706
90antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68606002
91GTP biosynthetic process (GO:0006183)2.67792474
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67667396
93cytochrome complex assembly (GO:0017004)2.65568662
94negative regulation of T cell apoptotic process (GO:0070233)2.63325992
95establishment of protein localization to mitochondrion (GO:0072655)2.62162542
96maturation of SSU-rRNA (GO:0030490)2.60307049
97ribosomal large subunit biogenesis (GO:0042273)2.59907195
98positive regulation of calcium-mediated signaling (GO:0050850)2.59234233
99negative regulation of calcium ion transport into cytosol (GO:0010523)2.58210440
100spliceosomal snRNP assembly (GO:0000387)2.58209854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89048963
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.39464321
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.98675545
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.94359480
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59110420
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45389289
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.10396149
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07268088
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.92825764
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90451377
11VDR_23849224_ChIP-Seq_CD4+_Human2.83296349
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62015811
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54084439
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.37204972
15FOXP3_21729870_ChIP-Seq_TREG_Human2.36516470
16ELK1_19687146_ChIP-ChIP_HELA_Human2.32843204
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.25108709
18VDR_22108803_ChIP-Seq_LS180_Human2.22725874
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18117240
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07502297
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.99774716
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93286819
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92980059
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92854706
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89958661
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.83551419
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81034870
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80141569
29E2F7_22180533_ChIP-Seq_HELA_Human1.78863602
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70567640
31ZNF274_21170338_ChIP-Seq_K562_Hela1.69711372
32IGF1R_20145208_ChIP-Seq_DFB_Human1.68624536
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61256240
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59821261
35MYC_18940864_ChIP-ChIP_HL60_Human1.56754349
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55776835
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.54954792
38GABP_19822575_ChIP-Seq_HepG2_Human1.52553822
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51649614
40DCP1A_22483619_ChIP-Seq_HELA_Human1.51501045
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51335201
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44655593
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41585992
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40967762
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.40836971
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39021955
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38762181
48PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37461798
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35907766
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35695404
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.35690200
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34127978
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32839329
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31821928
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.27220889
56TP53_22573176_ChIP-Seq_HFKS_Human1.26974145
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26833219
58CIITA_25753668_ChIP-Seq_RAJI_Human1.26721739
59TTF2_22483619_ChIP-Seq_HELA_Human1.26452961
60AR_20517297_ChIP-Seq_VCAP_Human1.26167935
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24882603
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23415628
63XRN2_22483619_ChIP-Seq_HELA_Human1.23341977
64GATA3_26560356_Chip-Seq_TH2_Human1.22694128
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22097415
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.21853386
67MYB_26560356_Chip-Seq_TH2_Human1.21146985
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16992965
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16149932
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12500668
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10685109
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10063723
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09404017
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08173730
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06725189
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06251648
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05796132
78EWS_26573619_Chip-Seq_HEK293_Human1.04713781
79NANOG_20526341_ChIP-Seq_ESCs_Human1.04182216
80ERG_20517297_ChIP-Seq_VCAP_Human1.03788808
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03677356
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02173626
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.02173626
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00726167
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97738118
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95565999
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95525092
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94499209
89IRF1_19129219_ChIP-ChIP_H3396_Human0.91071712
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90408474
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90233625
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89740556
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89589515
94NCOR_22424771_ChIP-Seq_293T_Human0.88901470
95BCL6_27268052_Chip-Seq_Bcells_Human0.87831544
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87613719
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.87188205
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.87179847
99HTT_18923047_ChIP-ChIP_STHdh_Human0.85608887
100TAF2_19829295_ChIP-Seq_ESCs_Human0.85482591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.53899071
2MP0002102_abnormal_ear_morphology2.88377247
3MP0008872_abnormal_physiological_respon2.48521188
4MP0003786_premature_aging2.38648943
5MP0002138_abnormal_hepatobiliary_system2.37341805
6MP0006072_abnormal_retinal_apoptosis2.34436427
7MP0006292_abnormal_olfactory_placode2.22650126
8MP0003763_abnormal_thymus_physiology2.19124988
9MP0009785_altered_susceptibility_to2.16636743
10MP0008875_abnormal_xenobiotic_pharmacok2.15568099
11MP0002166_altered_tumor_susceptibility2.10668288
12MP0001835_abnormal_antigen_presentation1.98977588
13MP0002006_tumorigenesis1.97810291
14MP0006036_abnormal_mitochondrial_physio1.97209070
15MP0009333_abnormal_splenocyte_physiolog1.94893666
16MP0005645_abnormal_hypothalamus_physiol1.94554817
17MP0008058_abnormal_DNA_repair1.91514109
18MP0001529_abnormal_vocalization1.80880060
19MP0008877_abnormal_DNA_methylation1.79484325
20MP0006035_abnormal_mitochondrial_morpho1.77341494
21MP0001873_stomach_inflammation1.71383280
22MP0002837_dystrophic_cardiac_calcinosis1.70020136
23MP0004147_increased_porphyrin_level1.68642135
24MP0008789_abnormal_olfactory_epithelium1.66473595
25MP0005084_abnormal_gallbladder_morpholo1.66283792
26MP0000372_irregular_coat_pigmentation1.64975655
27MP0002163_abnormal_gland_morphology1.64582084
28MP0001905_abnormal_dopamine_level1.59119435
29MP0001800_abnormal_humoral_immune1.57202052
30MP0001968_abnormal_touch/_nociception1.56524740
31MP0002736_abnormal_nociception_after1.54959605
32MP0002148_abnormal_hypersensitivity_rea1.46569890
33MP0002638_abnormal_pupillary_reflex1.46238697
34MP0003718_maternal_effect1.45858847
35MP0006276_abnormal_autonomic_nervous1.45281444
36MP0001919_abnormal_reproductive_system1.44449996
37MP0005000_abnormal_immune_tolerance1.44017486
38MP0010094_abnormal_chromosome_stability1.41359671
39MP0003878_abnormal_ear_physiology1.40947212
40MP0005377_hearing/vestibular/ear_phenot1.40947212
41MP0003646_muscle_fatigue1.40512282
42MP0009697_abnormal_copulation1.40225296
43MP0002420_abnormal_adaptive_immunity1.38367700
44MP0002723_abnormal_immune_serum1.37049461
45MP0005360_urolithiasis1.37017298
46MP0003866_abnormal_defecation1.36300119
47MP0003806_abnormal_nucleotide_metabolis1.35088822
48MP0001819_abnormal_immune_cell1.34845980
49MP0002653_abnormal_ependyma_morphology1.31020601
50MP0005551_abnormal_eye_electrophysiolog1.30013998
51MP0005025_abnormal_response_to1.27971759
52MP0001984_abnormal_olfaction1.24530729
53MP0001485_abnormal_pinna_reflex1.22910816
54MP0002452_abnormal_antigen_presenting1.21542547
55MP0008995_early_reproductive_senescence1.19149547
56MP0000685_abnormal_immune_system1.17630235
57MP0005389_reproductive_system_phenotype1.16134655
58MP0003195_calcinosis1.13663082
59MP0005085_abnormal_gallbladder_physiolo1.13103059
60MP0002876_abnormal_thyroid_physiology1.12394710
61MP0001764_abnormal_homeostasis1.11675007
62MP0002277_abnormal_respiratory_mucosa1.11356232
63MP0003693_abnormal_embryo_hatching1.09321328
64MP0001986_abnormal_taste_sensitivity1.09036569
65MP0002234_abnormal_pharynx_morphology1.07862801
66MP0005646_abnormal_pituitary_gland1.07371115
67MP0000716_abnormal_immune_system1.06295941
68MP0001790_abnormal_immune_system1.05978067
69MP0005387_immune_system_phenotype1.05978067
70MP0005253_abnormal_eye_physiology1.05832649
71MP0006082_CNS_inflammation1.05167634
72MP0003787_abnormal_imprinting1.04441370
73MP0004142_abnormal_muscle_tone1.04422356
74MP0005410_abnormal_fertilization1.03899889
75MP0009764_decreased_sensitivity_to1.02732256
76MP0010386_abnormal_urinary_bladder1.02216801
77MP0004957_abnormal_blastocyst_morpholog1.01727510
78MP0002398_abnormal_bone_marrow1.01520652
79MP0002822_catalepsy1.00623225
80MP0000689_abnormal_spleen_morphology1.00525923
81MP0001845_abnormal_inflammatory_respons0.99880096
82MP0000703_abnormal_thymus_morphology0.98574820
83MP0005379_endocrine/exocrine_gland_phen0.96820746
84MP0001853_heart_inflammation0.96746614
85MP0003011_delayed_dark_adaptation0.95155013
86MP0005636_abnormal_mineral_homeostasis0.94599693
87MP0004742_abnormal_vestibular_system0.94021097
88MP0003186_abnormal_redox_activity0.90851539
89MP0002722_abnormal_immune_system0.89499911
90MP0005075_abnormal_melanosome_morpholog0.89473406
91MP0008469_abnormal_protein_level0.89130519
92MP0005499_abnormal_olfactory_system0.88744134
93MP0005394_taste/olfaction_phenotype0.88744134
94MP0009379_abnormal_foot_pigmentation0.88271984
95MP0002405_respiratory_system_inflammati0.85497839
96MP0002429_abnormal_blood_cell0.83020586
97MP0003252_abnormal_bile_duct0.82142974
98MP0001501_abnormal_sleep_pattern0.78818355
99MP0002019_abnormal_tumor_incidence0.78106268
100MP0001119_abnormal_female_reproductive0.77140244

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.98263873
2Mitochondrial inheritance (HP:0001427)4.74907172
3Aplastic anemia (HP:0001915)4.64755892
4Abnormal mitochondria in muscle tissue (HP:0008316)4.60914099
5Acute encephalopathy (HP:0006846)4.42356688
6Increased CSF lactate (HP:0002490)4.20996592
7Hepatocellular necrosis (HP:0001404)4.08837402
8Progressive macrocephaly (HP:0004481)4.04927327
9Increased hepatocellular lipid droplets (HP:0006565)3.85065146
10Hepatic necrosis (HP:0002605)3.74359580
11IgG deficiency (HP:0004315)3.47477548
12Lipid accumulation in hepatocytes (HP:0006561)3.43517357
13Cerebral edema (HP:0002181)3.42830047
14Renal Fanconi syndrome (HP:0001994)3.30653649
15Abnormality of T cell number (HP:0011839)3.27222386
16Abnormality of B cell number (HP:0010975)3.12937203
17Increased intramyocellular lipid droplets (HP:0012240)3.08089039
18T lymphocytopenia (HP:0005403)3.06201634
19Pancytopenia (HP:0001876)3.05524917
20Increased serum lactate (HP:0002151)3.03192996
21Severe combined immunodeficiency (HP:0004430)3.00976118
223-Methylglutaconic aciduria (HP:0003535)2.96861564
23Hypoproteinemia (HP:0003075)2.95604512
24Elevated erythrocyte sedimentation rate (HP:0003565)2.89173999
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89016435
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89016435
27Congenital stationary night blindness (HP:0007642)2.88228632
28Lactic acidosis (HP:0003128)2.87317673
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79275070
30Hyperglycinemia (HP:0002154)2.74032571
31Respiratory failure (HP:0002878)2.70719536
32Pancreatic cysts (HP:0001737)2.70450563
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68265008
34Optic disc pallor (HP:0000543)2.63747385
35Increased IgM level (HP:0003496)2.61809856
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54191341
37Lethargy (HP:0001254)2.54135693
38Methylmalonic aciduria (HP:0012120)2.53282371
39Autoimmune hemolytic anemia (HP:0001890)2.52042705
40Colon cancer (HP:0003003)2.51510997
41Increased muscle lipid content (HP:0009058)2.51497846
42Exertional dyspnea (HP:0002875)2.51203631
43Abolished electroretinogram (ERG) (HP:0000550)2.49993430
44Methylmalonic acidemia (HP:0002912)2.45011039
45Generalized aminoaciduria (HP:0002909)2.44829969
46Combined immunodeficiency (HP:0005387)2.44530972
47Exercise intolerance (HP:0003546)2.43003592
48Oral leukoplakia (HP:0002745)2.38394066
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38042570
50Abnormality of midbrain morphology (HP:0002418)2.36635615
51Molar tooth sign on MRI (HP:0002419)2.36635615
52Reduced antithrombin III activity (HP:0001976)2.33983870
53Abnormal rod and cone electroretinograms (HP:0008323)2.33212460
54Abnormality of eosinophils (HP:0001879)2.31686055
55Pancreatic fibrosis (HP:0100732)2.31411272
56Congenital, generalized hypertrichosis (HP:0004540)2.31197968
57Autoimmune thrombocytopenia (HP:0001973)2.25342877
58True hermaphroditism (HP:0010459)2.22236539
59Type I transferrin isoform profile (HP:0003642)2.20786646
60Abnormality of T cells (HP:0002843)2.18394379
61Eosinophilia (HP:0001880)2.17299273
62Leukodystrophy (HP:0002415)2.15042105
63B lymphocytopenia (HP:0010976)2.11231070
64Thyroiditis (HP:0100646)2.09214039
65Abnormality of serum amino acid levels (HP:0003112)2.05981074
66Pendular nystagmus (HP:0012043)2.04684216
67Abnormality of the renal cortex (HP:0011035)2.03347083
68Dicarboxylic aciduria (HP:0003215)2.02160199
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02160199
70Abnormality of glycine metabolism (HP:0010895)1.96571061
71Abnormality of serine family amino acid metabolism (HP:0010894)1.96571061
72Aplasia/hypoplasia of the uterus (HP:0008684)1.94678996
73Stomach cancer (HP:0012126)1.93039081
74Abnormality of renal resorption (HP:0011038)1.91054775
75CNS demyelination (HP:0007305)1.89685176
76Hyperphosphaturia (HP:0003109)1.88023655
77Constricted visual fields (HP:0001133)1.87610851
78Attenuation of retinal blood vessels (HP:0007843)1.86426085
79Abnormality of urine glucose concentration (HP:0011016)1.85637508
80Glycosuria (HP:0003076)1.85637508
81Neonatal respiratory distress (HP:0002643)1.84828689
82Renal cortical cysts (HP:0000803)1.84450611
83Opisthotonus (HP:0002179)1.81276629
84Abnormality of the prostate (HP:0008775)1.81093063
85Delayed CNS myelination (HP:0002188)1.79711047
86Granulocytopenia (HP:0001913)1.78113383
87Abnormality of the ileum (HP:0001549)1.75535845
88Reticulocytopenia (HP:0001896)1.75322983
89Emotional lability (HP:0000712)1.73311170
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72615935
91Abnormality of alanine metabolism (HP:0010916)1.72615935
92Hyperalaninemia (HP:0003348)1.72615935
93Respiratory difficulties (HP:0002880)1.72338772
94Meckel diverticulum (HP:0002245)1.71087620
95Abnormal biliary tract physiology (HP:0012439)1.68697444
96Bile duct proliferation (HP:0001408)1.68697444
97Abnormal glycosylation (HP:0012345)1.68161055
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68161055
99Abnormal protein N-linked glycosylation (HP:0012347)1.68161055
100Abnormal protein glycosylation (HP:0012346)1.68161055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.98105994
2VRK23.72895673
3TESK23.60610731
4TXK3.57578322
5ZAK3.15065956
6STK162.68855638
7MAP4K22.61801322
8BUB12.61118726
9TLK12.55874004
10BCKDK2.48842079
11TAOK32.15016748
12VRK12.13931013
13MST41.92510428
14LIMK11.84583097
15MAP3K121.82794539
16TESK11.82457215
17ADRBK21.82018078
18NUAK11.73267205
19GRK11.62037733
20NEK11.53385114
21SRPK11.47622119
22EIF2AK31.43684922
23TIE11.41733718
24MAP4K11.39336813
25NME11.38533202
26CSNK1G31.30811667
27PASK1.29173836
28PINK11.24794118
29GRK61.21317552
30DAPK11.20596312
31MAP3K111.19148994
32WNK41.16763086
33BCR1.11350160
34OXSR11.05238269
35CSNK1A1L1.02855000
36MYLK1.02259703
37CSNK1G10.96848283
38TRIM280.95485380
39ITK0.95457762
40CSNK1G20.94666093
41DYRK20.94467930
42MAPKAPK30.87738048
43INSRR0.86953345
44MAP2K70.86798571
45WNK30.85124669
46CDC70.83753936
47TEC0.83727437
48EIF2AK10.83556453
49STK390.83034516
50SCYL20.81285584
51PBK0.79392607
52TSSK60.76872742
53PLK40.75205966
54PLK20.75130011
55SYK0.75002022
56PLK30.74748298
57PRKCQ0.73194763
58MUSK0.68852503
59CDK190.68307562
60FRK0.67898917
61PIM20.63232562
62RPS6KA50.61368760
63CDK80.57226179
64PLK10.57101276
65ERBB30.56312490
66AURKA0.55741525
67PIK3CG0.55317489
68CAMKK20.53463712
69AURKB0.52990564
70IKBKE0.52941736
71PHKG10.52887159
72PHKG20.52887159
73IKBKB0.51834811
74BTK0.51431322
75GRK70.50913248
76LCK0.49161443
77TNK20.48709039
78CSNK2A10.46955036
79CLK10.46258072
80LMTK20.45860732
81ADRBK10.45320532
82GRK50.44977617
83LYN0.42932363
84ATR0.41626731
85MAP2K60.41053273
86MAPK130.40922101
87CSNK2A20.39900725
88TAF10.39485331
89FES0.38390364
90IGF1R0.37959970
91BMPR1B0.36688238
92ABL20.35514109
93ZAP700.34380153
94EIF2AK20.34014049
95DAPK30.33583577
96WEE10.33069537
97CAMKK10.32931269
98PRKCE0.32010180
99KIT0.31722650
100PRKACA0.30066301

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.39737673
2Oxidative phosphorylation_Homo sapiens_hsa001904.01287081
3Parkinsons disease_Homo sapiens_hsa050123.46588573
4RNA polymerase_Homo sapiens_hsa030202.94738351
5Primary immunodeficiency_Homo sapiens_hsa053402.91067463
6Ribosome_Homo sapiens_hsa030102.71480906
7Huntingtons disease_Homo sapiens_hsa050162.27602480
8Alzheimers disease_Homo sapiens_hsa050102.23027021
9DNA replication_Homo sapiens_hsa030302.16120224
10Mismatch repair_Homo sapiens_hsa034302.14504209
11Protein export_Homo sapiens_hsa030602.08054598
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92856534
13Homologous recombination_Homo sapiens_hsa034401.86807679
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83620942
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80918310
16Pyrimidine metabolism_Homo sapiens_hsa002401.71947632
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70227613
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64892827
19Base excision repair_Homo sapiens_hsa034101.60295506
20Antigen processing and presentation_Homo sapiens_hsa046121.60244570
21Cardiac muscle contraction_Homo sapiens_hsa042601.51717798
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51081888
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48189234
24Propanoate metabolism_Homo sapiens_hsa006401.44028328
25Spliceosome_Homo sapiens_hsa030401.35157032
26Nucleotide excision repair_Homo sapiens_hsa034201.30451855
27Autoimmune thyroid disease_Homo sapiens_hsa053201.29960564
28RNA degradation_Homo sapiens_hsa030181.28470110
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27154330
30Allograft rejection_Homo sapiens_hsa053301.26997019
31One carbon pool by folate_Homo sapiens_hsa006701.26601294
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24927231
33Graft-versus-host disease_Homo sapiens_hsa053321.20436973
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14083137
35Purine metabolism_Homo sapiens_hsa002301.10351271
36Hematopoietic cell lineage_Homo sapiens_hsa046401.10083015
37Peroxisome_Homo sapiens_hsa041461.06254291
38Asthma_Homo sapiens_hsa053101.03718953
39Fanconi anemia pathway_Homo sapiens_hsa034601.02749738
40Non-homologous end-joining_Homo sapiens_hsa034501.00172678
41Caffeine metabolism_Homo sapiens_hsa002320.95334861
42Nitrogen metabolism_Homo sapiens_hsa009100.93655326
43Phototransduction_Homo sapiens_hsa047440.92772967
44RNA transport_Homo sapiens_hsa030130.92638452
45Type I diabetes mellitus_Homo sapiens_hsa049400.91972530
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.91256716
47Pyruvate metabolism_Homo sapiens_hsa006200.88514382
48Chemical carcinogenesis_Homo sapiens_hsa052040.87406007
49Linoleic acid metabolism_Homo sapiens_hsa005910.86428761
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86055351
51Tryptophan metabolism_Homo sapiens_hsa003800.85006233
52Fatty acid elongation_Homo sapiens_hsa000620.84756899
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.83576472
54Butanoate metabolism_Homo sapiens_hsa006500.83045789
55Folate biosynthesis_Homo sapiens_hsa007900.82092972
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80900297
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80557864
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77225295
59Basal transcription factors_Homo sapiens_hsa030220.74405568
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73185980
61Steroid biosynthesis_Homo sapiens_hsa001000.72338731
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.71830387
63Metabolic pathways_Homo sapiens_hsa011000.71822511
64Glutathione metabolism_Homo sapiens_hsa004800.71297734
65Systemic lupus erythematosus_Homo sapiens_hsa053220.71133348
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67556699
67T cell receptor signaling pathway_Homo sapiens_hsa046600.67064212
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66525944
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65738187
70Rheumatoid arthritis_Homo sapiens_hsa053230.64310025
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63288668
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.61337277
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.59574298
74Regulation of autophagy_Homo sapiens_hsa041400.58802902
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57139901
76Retinol metabolism_Homo sapiens_hsa008300.55156730
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54723306
78Sulfur relay system_Homo sapiens_hsa041220.51868249
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49190425
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47079792
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47005465
82Collecting duct acid secretion_Homo sapiens_hsa049660.46805775
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46407789
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44916104
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44407674
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41931264
87Fatty acid degradation_Homo sapiens_hsa000710.41384055
88Arachidonic acid metabolism_Homo sapiens_hsa005900.41073678
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40529627
90Epstein-Barr virus infection_Homo sapiens_hsa051690.38504322
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.38211073
92Carbon metabolism_Homo sapiens_hsa012000.37824585
93Shigellosis_Homo sapiens_hsa051310.36808681
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34511630
95Selenocompound metabolism_Homo sapiens_hsa004500.33972374
96beta-Alanine metabolism_Homo sapiens_hsa004100.33168333
97Fat digestion and absorption_Homo sapiens_hsa049750.32316532
98Olfactory transduction_Homo sapiens_hsa047400.30018760
99Sulfur metabolism_Homo sapiens_hsa009200.29347119
100Viral myocarditis_Homo sapiens_hsa054160.28009733

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »