PPIAL4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.16733913
2ribosomal small subunit assembly (GO:0000028)6.97619346
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.73915136
4ATP synthesis coupled proton transport (GO:0015986)4.84103378
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.84103378
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66510429
7water-soluble vitamin biosynthetic process (GO:0042364)4.57678156
8cytidine metabolic process (GO:0046087)4.45876248
9cytidine catabolic process (GO:0006216)4.45876248
10cytidine deamination (GO:0009972)4.45876248
11behavioral response to nicotine (GO:0035095)4.12320267
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11617920
13pyrimidine ribonucleoside catabolic process (GO:0046133)4.05488277
14protein neddylation (GO:0045116)3.98856193
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.97699109
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.97699109
17ribosomal large subunit biogenesis (GO:0042273)3.96022158
18protein complex biogenesis (GO:0070271)3.95999518
19maturation of SSU-rRNA (GO:0030490)3.95403929
20proteasome assembly (GO:0043248)3.89059734
21piRNA metabolic process (GO:0034587)3.86603645
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86048489
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.86048489
24NADH dehydrogenase complex assembly (GO:0010257)3.86048489
25protein polyglutamylation (GO:0018095)3.85377571
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.75636856
27respiratory electron transport chain (GO:0022904)3.74883346
28electron transport chain (GO:0022900)3.73689444
29chaperone-mediated protein transport (GO:0072321)3.65664838
30viral transcription (GO:0019083)3.47655797
31translational termination (GO:0006415)3.41575188
32mitochondrial respiratory chain complex assembly (GO:0033108)3.40927188
33platelet dense granule organization (GO:0060155)3.40324669
34protein-cofactor linkage (GO:0018065)3.39967418
35pyrimidine nucleotide catabolic process (GO:0006244)3.38565710
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.36570987
37negative regulation of mast cell activation (GO:0033004)3.28711679
38phosphorylated carbohydrate dephosphorylation (GO:0046838)3.28654710
39inositol phosphate dephosphorylation (GO:0046855)3.28654710
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.28342782
41termination of RNA polymerase III transcription (GO:0006386)3.28342782
42ribosomal small subunit biogenesis (GO:0042274)3.23076390
43regulation of cilium movement (GO:0003352)3.20932248
44negative regulation of telomere maintenance (GO:0032205)3.18985491
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18319313
46translational elongation (GO:0006414)3.16370841
47regulation of chronic inflammatory response (GO:0002676)3.15784829
48protein targeting to ER (GO:0045047)3.12976243
49ketone body metabolic process (GO:1902224)3.12975770
50cotranslational protein targeting to membrane (GO:0006613)3.09613120
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06526279
52pseudouridine synthesis (GO:0001522)3.04289012
53hydrogen ion transmembrane transport (GO:1902600)2.99334154
54base-excision repair, AP site formation (GO:0006285)2.98789832
55establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98277456
56cellular ketone body metabolic process (GO:0046950)2.96506688
57axoneme assembly (GO:0035082)2.96193194
58positive regulation of defense response to virus by host (GO:0002230)2.93481086
59inositol phosphate catabolic process (GO:0071545)2.92677569
60protein localization to endoplasmic reticulum (GO:0070972)2.91707289
61ATP biosynthetic process (GO:0006754)2.89088860
62mannosylation (GO:0097502)2.87393320
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85317584
64cellular component biogenesis (GO:0044085)2.84504752
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84096405
66regulation of action potential (GO:0098900)2.83100652
67purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.81609297
68regulation of cellular amino acid metabolic process (GO:0006521)2.80706705
69proton transport (GO:0015992)2.79634508
70translation (GO:0006412)2.77650670
71preassembly of GPI anchor in ER membrane (GO:0016254)2.77587470
72ubiquinone biosynthetic process (GO:0006744)2.76449934
73hydrogen transport (GO:0006818)2.76186213
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75502160
75regulation of mitochondrial translation (GO:0070129)2.74549938
76positive regulation of humoral immune response (GO:0002922)2.74096581
77GPI anchor metabolic process (GO:0006505)2.74052565
78branched-chain amino acid catabolic process (GO:0009083)2.70280747
79negative regulation of calcium ion transport into cytosol (GO:0010523)2.69510235
80tRNA processing (GO:0008033)2.69428936
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69360103
82anterograde synaptic vesicle transport (GO:0048490)2.68370941
83protein K6-linked ubiquitination (GO:0085020)2.65604653
84L-fucose catabolic process (GO:0042355)2.65349186
85fucose catabolic process (GO:0019317)2.65349186
86L-fucose metabolic process (GO:0042354)2.65349186
87GPI anchor biosynthetic process (GO:0006506)2.65171671
88cellular protein complex disassembly (GO:0043624)2.64075564
89male meiosis I (GO:0007141)2.62979491
90deoxyribonucleotide catabolic process (GO:0009264)2.62821152
91cellular response to exogenous dsRNA (GO:0071360)2.60670781
92phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60053776
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.58932138
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58329356
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58329356
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58329356
97deoxyribose phosphate catabolic process (GO:0046386)2.58294502
98vitamin biosynthetic process (GO:0009110)2.57947128
99GTP biosynthetic process (GO:0006183)2.57924017
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57563427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88471235
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79749724
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77218548
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.76998859
5ZNF274_21170338_ChIP-Seq_K562_Hela3.50904796
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18009639
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.14826719
8VDR_22108803_ChIP-Seq_LS180_Human3.13945005
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06283364
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.03365902
11IGF1R_20145208_ChIP-Seq_DFB_Human2.56417748
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.52958149
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42523171
14VDR_23849224_ChIP-Seq_CD4+_Human2.40746106
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.31482040
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29396045
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03351379
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02569182
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97679061
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.91965291
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91056894
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78924279
23IRF1_19129219_ChIP-ChIP_H3396_Human1.77327504
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74749358
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74274526
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72436422
27MYC_18940864_ChIP-ChIP_HL60_Human1.72142704
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68330099
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66417467
30ELK1_19687146_ChIP-ChIP_HELA_Human1.66349917
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.63336164
32EWS_26573619_Chip-Seq_HEK293_Human1.60959401
33FOXP3_21729870_ChIP-Seq_TREG_Human1.56323718
34TP53_22573176_ChIP-Seq_HFKS_Human1.55462435
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54730532
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.47337226
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46756163
38FUS_26573619_Chip-Seq_HEK293_Human1.41845022
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40960653
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40635836
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33808648
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28171747
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.27282294
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26613075
45AR_20517297_ChIP-Seq_VCAP_Human1.25746685
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24828967
47* FOXA1_25329375_ChIP-Seq_VCAP_Human1.24708946
48* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24708946
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23613175
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22285014
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.22009404
52TTF2_22483619_ChIP-Seq_HELA_Human1.21342550
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19736659
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.19542208
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19163856
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18951870
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.17454974
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16240078
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13356984
60TAF2_19829295_ChIP-Seq_ESCs_Human1.12321958
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12066931
62SOX2_19829295_ChIP-Seq_ESCs_Human1.11549853
63NANOG_19829295_ChIP-Seq_ESCs_Human1.11549853
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10411169
65BCAT_22108803_ChIP-Seq_LS180_Human1.09873874
66MYC_19829295_ChIP-Seq_ESCs_Human1.09349384
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08109118
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08065397
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07095224
70ER_23166858_ChIP-Seq_MCF-7_Human1.05583518
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.04206041
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03102673
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03031825
74CBP_20019798_ChIP-Seq_JUKART_Human1.02759149
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02759149
76* GATA3_26560356_Chip-Seq_TH2_Human1.01879721
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01103011
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.00134597
79GABP_19822575_ChIP-Seq_HepG2_Human0.98564144
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97884055
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.97721581
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96012219
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95871095
84HOXB7_26014856_ChIP-Seq_BT474_Human0.95322975
85ERG_20517297_ChIP-Seq_VCAP_Human0.95231899
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94576010
87P300_19829295_ChIP-Seq_ESCs_Human0.94551557
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92470876
89* NANOG_20526341_ChIP-Seq_ESCs_Human0.91576581
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90957926
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90247849
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88651961
93NCOR_22424771_ChIP-Seq_293T_Human0.88461518
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88426982
95ERA_21632823_ChIP-Seq_H3396_Human0.88248294
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87649535
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87632970
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86959323
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85562866
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85030273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol3.60894787
2MP0006292_abnormal_olfactory_placode3.18863776
3MP0002102_abnormal_ear_morphology2.96713871
4MP0005671_abnormal_response_to2.72634269
5MP0009379_abnormal_foot_pigmentation2.61905149
6MP0008875_abnormal_xenobiotic_pharmacok2.23569015
7MP0008877_abnormal_DNA_methylation2.20974083
8MP0006276_abnormal_autonomic_nervous2.15486543
9MP0003724_increased_susceptibility_to2.14061786
10MP0006072_abnormal_retinal_apoptosis2.02675532
11MP0005084_abnormal_gallbladder_morpholo2.00552429
12MP0008872_abnormal_physiological_respon1.98772664
13MP0005551_abnormal_eye_electrophysiolog1.93191877
14MP0002138_abnormal_hepatobiliary_system1.91073400
15MP0004142_abnormal_muscle_tone1.85887383
16MP0005377_hearing/vestibular/ear_phenot1.85093511
17MP0003878_abnormal_ear_physiology1.85093511
18MP0001986_abnormal_taste_sensitivity1.81684472
19MP0001968_abnormal_touch/_nociception1.79434562
20MP0001485_abnormal_pinna_reflex1.75318181
21MP0002653_abnormal_ependyma_morphology1.74491901
22MP0000372_irregular_coat_pigmentation1.73167676
23MP0003195_calcinosis1.70368147
24MP0000465_gastrointestinal_hemorrhage1.70022717
25MP0002733_abnormal_thermal_nociception1.65018895
26MP0004885_abnormal_endolymph1.63769620
27MP0001529_abnormal_vocalization1.61026304
28MP0002163_abnormal_gland_morphology1.58678265
29MP0002272_abnormal_nervous_system1.58659714
30MP0003011_delayed_dark_adaptation1.58538899
31MP0008058_abnormal_DNA_repair1.57359481
32MP0002254_reproductive_system_inflammat1.53554427
33MP0002736_abnormal_nociception_after1.53221516
34MP0001905_abnormal_dopamine_level1.50527299
35MP0005646_abnormal_pituitary_gland1.48247642
36MP0005253_abnormal_eye_physiology1.47748419
37MP0005075_abnormal_melanosome_morpholog1.45422830
38MP0006036_abnormal_mitochondrial_physio1.43562839
39MP0003806_abnormal_nucleotide_metabolis1.42146566
40MP0004742_abnormal_vestibular_system1.41498865
41MP0002277_abnormal_respiratory_mucosa1.39330992
42MP0005389_reproductive_system_phenotype1.37505169
43MP0002837_dystrophic_cardiac_calcinosis1.36334453
44MP0004145_abnormal_muscle_electrophysio1.36244638
45MP0001919_abnormal_reproductive_system1.34672990
46MP0002234_abnormal_pharynx_morphology1.32791112
47MP0001970_abnormal_pain_threshold1.32588501
48MP0002876_abnormal_thyroid_physiology1.30148375
49MP0001486_abnormal_startle_reflex1.29805486
50MP0003880_abnormal_central_pattern1.28617196
51MP0008789_abnormal_olfactory_epithelium1.19272767
52MP0004043_abnormal_pH_regulation1.18688342
53MP0002909_abnormal_adrenal_gland1.17556466
54MP0009764_decreased_sensitivity_to1.16623000
55MP0001501_abnormal_sleep_pattern1.15975646
56MP0003786_premature_aging1.12431011
57MP0009745_abnormal_behavioral_response1.11947163
58MP0003136_yellow_coat_color1.10696317
59MP0009785_altered_susceptibility_to1.09713786
60MP0002638_abnormal_pupillary_reflex1.09434232
61MP0008995_early_reproductive_senescence1.06023818
62MP0001293_anophthalmia1.05223763
63MP0001835_abnormal_antigen_presentation1.04235049
64MP0003186_abnormal_redox_activity1.01378870
65MP0002148_abnormal_hypersensitivity_rea0.99124884
66MP0010386_abnormal_urinary_bladder0.98207580
67MP0001963_abnormal_hearing_physiology0.96238239
68MP0001873_stomach_inflammation0.94884556
69MP0002095_abnormal_skin_pigmentation0.94316166
70MP0005174_abnormal_tail_pigmentation0.94141996
71MP0003763_abnormal_thymus_physiology0.93731991
72MP0000685_abnormal_immune_system0.93056104
73MP0003646_muscle_fatigue0.92567574
74MP0001800_abnormal_humoral_immune0.92257752
75MP0009333_abnormal_splenocyte_physiolog0.90679563
76MP0003718_maternal_effect0.90509735
77MP0005000_abnormal_immune_tolerance0.90392263
78MP0005379_endocrine/exocrine_gland_phen0.90290413
79MP0004147_increased_porphyrin_level0.90110280
80MP0000631_abnormal_neuroendocrine_gland0.90031247
81MP0005410_abnormal_fertilization0.89486118
82MP0003635_abnormal_synaptic_transmissio0.88748058
83MP0001790_abnormal_immune_system0.87065818
84MP0005387_immune_system_phenotype0.87065818
85MP0002184_abnormal_innervation0.83127705
86MP0004381_abnormal_hair_follicle0.82550044
87MP0002723_abnormal_immune_serum0.82086244
88MP0002557_abnormal_social/conspecific_i0.80533284
89MP0003137_abnormal_impulse_conducting0.79553522
90MP0002160_abnormal_reproductive_system0.77105763
91MP0001929_abnormal_gametogenesis0.76984806
92MP0002210_abnormal_sex_determination0.76954742
93MP0005167_abnormal_blood-brain_barrier0.75989697
94MP0002006_tumorigenesis0.74299492
95MP0005195_abnormal_posterior_eye0.74211275
96MP0002572_abnormal_emotion/affect_behav0.73462505
97MP0002420_abnormal_adaptive_immunity0.73170303
98MP0003866_abnormal_defecation0.73085706
99MP0003122_maternal_imprinting0.72384026
100MP0004133_heterotaxia0.72106111

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.81584966
2Acute necrotizing encephalopathy (HP:0006965)4.53019390
3Mitochondrial inheritance (HP:0001427)4.20433628
4Hepatocellular necrosis (HP:0001404)4.12146586
5Abnormal mitochondria in muscle tissue (HP:0008316)4.09226788
6Acute encephalopathy (HP:0006846)4.07136184
7Increased CSF lactate (HP:0002490)4.01552296
8Hepatic necrosis (HP:0002605)3.67549340
9Progressive macrocephaly (HP:0004481)3.66741250
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.49775167
11Increased hepatocellular lipid droplets (HP:0006565)3.45794699
12Congenital stationary night blindness (HP:0007642)3.33050483
13Pancreatic cysts (HP:0001737)3.27048247
14Lipid accumulation in hepatocytes (HP:0006561)3.24717523
15Pancreatic fibrosis (HP:0100732)3.16392575
16Cerebral edema (HP:0002181)3.09730926
17Molar tooth sign on MRI (HP:0002419)3.05498080
18Abnormality of midbrain morphology (HP:0002418)3.05498080
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.00461026
20Abnormality of the labia minora (HP:0012880)2.90583154
21Increased serum lactate (HP:0002151)2.81978374
22Elevated erythrocyte sedimentation rate (HP:0003565)2.81229589
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80241121
24Type 2 muscle fiber atrophy (HP:0003554)2.75262210
25Abnormality of cells of the erythroid lineage (HP:0012130)2.73148102
26Abnormal rod and cone electroretinograms (HP:0008323)2.71890757
27Reticulocytopenia (HP:0001896)2.68900877
28True hermaphroditism (HP:0010459)2.63753057
29Renal Fanconi syndrome (HP:0001994)2.60759055
30Aplasia/hypoplasia of the uterus (HP:0008684)2.58461074
31Optic disc pallor (HP:0000543)2.51262541
32Abnormal number of erythroid precursors (HP:0012131)2.50106843
33Muscle fiber atrophy (HP:0100295)2.46920475
34Abnormality of alanine metabolism (HP:0010916)2.43206795
35Hyperalaninemia (HP:0003348)2.43206795
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43206795
37Increased intramyocellular lipid droplets (HP:0012240)2.42692410
38Methylmalonic acidemia (HP:0002912)2.41357992
39Nephronophthisis (HP:0000090)2.40577009
40Lactic acidosis (HP:0003128)2.40415534
41IgG deficiency (HP:0004315)2.40365366
42Respiratory failure (HP:0002878)2.38707738
43Pendular nystagmus (HP:0012043)2.36988327
44Abolished electroretinogram (ERG) (HP:0000550)2.36837181
45Hypomagnesemia (HP:0002917)2.35823227
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35143782
47Hypoplasia of the uterus (HP:0000013)2.29165357
48Short tibia (HP:0005736)2.24728600
49Medial flaring of the eyebrow (HP:0010747)2.24561179
50Lethargy (HP:0001254)2.23976323
51Exertional dyspnea (HP:0002875)2.18710107
52Abnormality of the renal medulla (HP:0100957)2.18626899
53Exercise intolerance (HP:0003546)2.18426368
54Methylmalonic aciduria (HP:0012120)2.17751556
55Decreased central vision (HP:0007663)2.17502609
56Chorioretinal atrophy (HP:0000533)2.17250454
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.16692623
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15354097
59Abnormal protein N-linked glycosylation (HP:0012347)2.15354097
60Abnormal protein glycosylation (HP:0012346)2.15354097
61Abnormal glycosylation (HP:0012345)2.15354097
62Congenital hepatic fibrosis (HP:0002612)2.14270607
63Parakeratosis (HP:0001036)2.12836248
64Asplenia (HP:0001746)2.11170592
65Hyperglycinemia (HP:0002154)2.08108329
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.06708298
67Abnormality of the renal cortex (HP:0011035)2.05741136
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03893516
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03893516
70Increased muscle lipid content (HP:0009058)2.01163777
71Aplastic anemia (HP:0001915)1.98888853
72Macrocytic anemia (HP:0001972)1.98881157
73Attenuation of retinal blood vessels (HP:0007843)1.97110865
74Leukodystrophy (HP:0002415)1.94789341
75Abnormality of B cell number (HP:0010975)1.93647610
76Colon cancer (HP:0003003)1.93020349
77Absent thumb (HP:0009777)1.89703195
78Ketosis (HP:0001946)1.88583109
79Abnormality of magnesium homeostasis (HP:0004921)1.88355794
80Retinal dysplasia (HP:0007973)1.88339582
81Congenital, generalized hypertrichosis (HP:0004540)1.87730053
82B lymphocytopenia (HP:0010976)1.86866324
83CNS demyelination (HP:0007305)1.86063568
84Cystic liver disease (HP:0006706)1.85256464
85Agitation (HP:0000713)1.84763889
86Myositis (HP:0100614)1.84516867
87Adactyly (HP:0009776)1.83995656
88Thyroid-stimulating hormone excess (HP:0002925)1.83935948
89Increased corneal curvature (HP:0100692)1.80534110
90Keratoconus (HP:0000563)1.80534110
91Abnormal biliary tract physiology (HP:0012439)1.80224791
92Bile duct proliferation (HP:0001408)1.80224791
93Emotional lability (HP:0000712)1.79492585
94Supernumerary spleens (HP:0009799)1.77166447
95Inability to walk (HP:0002540)1.76233901
96Abnormality of urine glucose concentration (HP:0011016)1.76001293
97Glycosuria (HP:0003076)1.76001293
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.73783899
99Hypoplasia of the fovea (HP:0007750)1.73783899
100Abnormality of the anterior horn cell (HP:0006802)1.72752107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.61861242
2BCKDK3.41099066
3TLK13.24191142
4ZAK2.87178658
5TXK2.58648691
6WNK42.34013377
7NME12.22766121
8GRK12.15262665
9ADRBK22.12502689
10TAOK32.10967332
11VRK22.00046128
12GRK61.91408130
13NUAK11.85905357
14FES1.71676950
15MAP4K11.63419342
16VRK11.58779840
17CSNK1G31.53082129
18KDR1.52702208
19WNK31.52399132
20INSRR1.51163413
21PINK11.51152009
22MAP3K121.50300058
23FRK1.48979401
24TESK21.47123363
25CSNK1G21.44714589
26CSNK1G11.41145387
27DAPK11.40046139
28STK391.39839846
29BUB11.29711242
30CSNK1A1L1.23701123
31MST41.18874228
32MAP2K61.17961730
33OXSR11.11932438
34DYRK21.11158979
35PASK1.11123069
36MAP3K41.00716892
37TIE10.98717832
38MAP3K110.92025862
39PRKCQ0.91506621
40MAP2K70.88798021
41CAMKK20.86367685
42STK160.85425973
43CDK190.84138178
44OBSCN0.84002906
45IKBKB0.81883345
46TSSK60.81822388
47TRIM280.80199314
48PIM10.78291919
49LIMK10.77371690
50DAPK20.75512758
51BMPR1B0.73194901
52NEK10.71189807
53MKNK10.70658720
54BTK0.70277733
55NEK20.67349403
56ITK0.66585602
57ALK0.65095129
58TEC0.64056333
59SYK0.63117978
60PBK0.62101954
61DAPK30.61001724
62PHKG10.59851504
63PHKG20.59851504
64MATK0.58995355
65RPS6KA50.57943365
66ADRBK10.57407236
67BRSK20.55942954
68MAPKAPK30.55565704
69LYN0.53979548
70MAP3K50.52402885
71LRRK20.51254226
72PRKCG0.50825635
73NME20.50277280
74KIT0.50208932
75TNK20.49015775
76SRPK10.48981019
77IKBKE0.46819900
78CSNK2A20.46278532
79CAMK2A0.44037631
80TAF10.43836440
81NTRK20.43058701
82MAP2K20.42889010
83MAPKAPK50.41544793
84MINK10.40934556
85CSNK2A10.40490596
86CAMK10.39568813
87PIK3CG0.38189969
88PIK3CA0.38121415
89IGF1R0.37442112
90PRKACA0.37437808
91MARK30.37326421
92PLK30.36918275
93CSNK1D0.35779141
94ATR0.35103187
95LCK0.35012667
96EIF2AK30.34839899
97PRKCI0.34772803
98CSNK1A10.34268663
99CCNB10.33891283
100MAPK130.33639004

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.83615695
2Ribosome_Homo sapiens_hsa030103.66272857
3Proteasome_Homo sapiens_hsa030503.45981529
4Parkinsons disease_Homo sapiens_hsa050123.26412382
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81873423
6RNA polymerase_Homo sapiens_hsa030202.75361528
7Protein export_Homo sapiens_hsa030602.39485485
8Alzheimers disease_Homo sapiens_hsa050102.16533726
9Huntingtons disease_Homo sapiens_hsa050162.11101500
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09853021
11Primary immunodeficiency_Homo sapiens_hsa053402.08708092
12Cardiac muscle contraction_Homo sapiens_hsa042602.07408736
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99027094
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95906650
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91123159
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85711443
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84467564
18Linoleic acid metabolism_Homo sapiens_hsa005911.78997982
19One carbon pool by folate_Homo sapiens_hsa006701.75616159
20Propanoate metabolism_Homo sapiens_hsa006401.65088644
21Phototransduction_Homo sapiens_hsa047441.63766631
22Butanoate metabolism_Homo sapiens_hsa006501.56455861
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55079475
24Regulation of autophagy_Homo sapiens_hsa041401.47424534
25RNA degradation_Homo sapiens_hsa030181.45179448
26Homologous recombination_Homo sapiens_hsa034401.43792980
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41969615
28Peroxisome_Homo sapiens_hsa041461.38435220
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37423200
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34744423
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31194797
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28670003
33Type I diabetes mellitus_Homo sapiens_hsa049401.27966553
34Pyrimidine metabolism_Homo sapiens_hsa002401.20956666
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15712698
36Purine metabolism_Homo sapiens_hsa002301.15141216
37Steroid biosynthesis_Homo sapiens_hsa001001.09362306
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01627928
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98836482
40Primary bile acid biosynthesis_Homo sapiens_hsa001200.97987857
41Basal transcription factors_Homo sapiens_hsa030220.95981929
42Chemical carcinogenesis_Homo sapiens_hsa052040.94540303
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.93799779
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.91566938
45Asthma_Homo sapiens_hsa053100.86266240
46Caffeine metabolism_Homo sapiens_hsa002320.85945333
47Nucleotide excision repair_Homo sapiens_hsa034200.83777128
48Fanconi anemia pathway_Homo sapiens_hsa034600.83093904
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.83017178
50Arachidonic acid metabolism_Homo sapiens_hsa005900.80908611
51Metabolic pathways_Homo sapiens_hsa011000.80764285
52Tryptophan metabolism_Homo sapiens_hsa003800.79169561
53Base excision repair_Homo sapiens_hsa034100.78432356
54Graft-versus-host disease_Homo sapiens_hsa053320.78307937
55Autoimmune thyroid disease_Homo sapiens_hsa053200.77902832
56Allograft rejection_Homo sapiens_hsa053300.76534876
57RNA transport_Homo sapiens_hsa030130.76152743
58Ether lipid metabolism_Homo sapiens_hsa005650.73550916
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73495213
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70432343
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69347942
62Hematopoietic cell lineage_Homo sapiens_hsa046400.68459126
63Taste transduction_Homo sapiens_hsa047420.64266364
64Sulfur metabolism_Homo sapiens_hsa009200.63431101
65Retinol metabolism_Homo sapiens_hsa008300.62950480
66Folate biosynthesis_Homo sapiens_hsa007900.61344422
67Fatty acid biosynthesis_Homo sapiens_hsa000610.59231048
68Olfactory transduction_Homo sapiens_hsa047400.58921273
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57463553
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57017216
71Ovarian steroidogenesis_Homo sapiens_hsa049130.56249611
72Spliceosome_Homo sapiens_hsa030400.55919449
73Morphine addiction_Homo sapiens_hsa050320.55889107
74Antigen processing and presentation_Homo sapiens_hsa046120.53743427
75Non-homologous end-joining_Homo sapiens_hsa034500.53279504
76Nicotine addiction_Homo sapiens_hsa050330.52750323
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51635165
78Nitrogen metabolism_Homo sapiens_hsa009100.49573031
79Collecting duct acid secretion_Homo sapiens_hsa049660.49539440
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.47572866
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.46627965
82Salivary secretion_Homo sapiens_hsa049700.45981569
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45129474
84Fatty acid metabolism_Homo sapiens_hsa012120.45109747
85N-Glycan biosynthesis_Homo sapiens_hsa005100.44670426
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44442229
87Serotonergic synapse_Homo sapiens_hsa047260.43986000
88Systemic lupus erythematosus_Homo sapiens_hsa053220.43302899
89Glutathione metabolism_Homo sapiens_hsa004800.43260870
90Mismatch repair_Homo sapiens_hsa034300.39666275
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38834171
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.37945491
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36506910
94Fat digestion and absorption_Homo sapiens_hsa049750.35400357
95Insulin secretion_Homo sapiens_hsa049110.32383840
96Glycerolipid metabolism_Homo sapiens_hsa005610.28450626
97GABAergic synapse_Homo sapiens_hsa047270.27820435
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26950437
99Sulfur relay system_Homo sapiens_hsa041220.26551529
100Dorso-ventral axis formation_Homo sapiens_hsa043200.25542177

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »