PPIAL4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.72732045
2cytidine metabolic process (GO:0046087)7.42456957
3cytidine catabolic process (GO:0006216)7.42456957
4cytidine deamination (GO:0009972)7.42456957
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.01209898
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.44172619
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.29085993
8sequestering of actin monomers (GO:0042989)5.01829128
9actin nucleation (GO:0045010)4.70876627
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.69348118
11negative regulation of T cell apoptotic process (GO:0070233)4.67031285
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31163692
13positive T cell selection (GO:0043368)4.17841848
14positive thymic T cell selection (GO:0045059)4.15952161
15negative regulation by host of viral transcription (GO:0043922)4.13452259
16regulation of B cell receptor signaling pathway (GO:0050855)4.08950238
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.08063088
18ATP synthesis coupled proton transport (GO:0015986)4.08063088
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.04760346
20T cell migration (GO:0072678)3.91972511
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90829154
22ribosomal small subunit assembly (GO:0000028)3.86985835
23negative T cell selection (GO:0043383)3.85327747
24positive regulation of B cell differentiation (GO:0045579)3.76682847
25respiratory electron transport chain (GO:0022904)3.67990271
26electron transport chain (GO:0022900)3.63085562
27negative regulation of lymphocyte apoptotic process (GO:0070229)3.62946898
28positive regulation of natural killer cell mediated immunity (GO:0002717)3.62443073
29negative regulation of viral genome replication (GO:0045071)3.61299477
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.58518171
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53693897
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.53531025
33pyrimidine nucleoside catabolic process (GO:0046135)3.50153242
34purine deoxyribonucleotide catabolic process (GO:0009155)3.49911609
35response to interferon-beta (GO:0035456)3.47876825
36regulation of activation of Janus kinase activity (GO:0010533)3.46372332
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43319291
38positive regulation of interleukin-8 secretion (GO:2000484)3.43152468
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.39535026
40deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.38851407
41cytolysis (GO:0019835)3.38594591
42regulation of cellular amino acid metabolic process (GO:0006521)3.38412170
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.36956796
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35708443
45regulation of regulatory T cell differentiation (GO:0045589)3.34840251
46metallo-sulfur cluster assembly (GO:0031163)3.34222861
47iron-sulfur cluster assembly (GO:0016226)3.34222861
48eosinophil chemotaxis (GO:0048245)3.32409933
49positive regulation of tolerance induction (GO:0002645)3.32033944
50macrophage chemotaxis (GO:0048246)3.31431634
51positive regulation of calcium-mediated signaling (GO:0050850)3.29772175
52cellular response to interleukin-15 (GO:0071350)3.29531307
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24664254
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24664254
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23716987
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23716987
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23716987
58regulation of T cell receptor signaling pathway (GO:0050856)3.20753775
59negative regulation of stress fiber assembly (GO:0051497)3.20412524
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.18423750
61proteasome assembly (GO:0043248)3.18164291
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16293744
63regulation of T cell tolerance induction (GO:0002664)3.16047459
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15462942
65regulation of B cell differentiation (GO:0045577)3.14245579
66regulation of natural killer cell mediated immunity (GO:0002715)3.14220588
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14220588
68thymic T cell selection (GO:0045061)3.14189391
69regulation of chronic inflammatory response (GO:0002676)3.10883620
70regulation of T cell apoptotic process (GO:0070232)3.07339833
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06777407
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06661504
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.06661504
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04872868
75positive regulation of gamma-delta T cell activation (GO:0046645)3.02681059
76negative regulation of ligase activity (GO:0051352)3.02549623
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02549623
78eosinophil migration (GO:0072677)3.02418314
79protein complex biogenesis (GO:0070271)3.02350284
80deoxyribonucleotide catabolic process (GO:0009264)3.01427437
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.00630978
82negative thymic T cell selection (GO:0045060)2.99345751
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99119017
84regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97815903
85positive regulation of cell killing (GO:0031343)2.96491051
86negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.95950068
87positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93539920
88regulation of interleukin-8 secretion (GO:2000482)2.91513393
89deoxyribose phosphate catabolic process (GO:0046386)2.90380896
90T cell receptor signaling pathway (GO:0050852)2.89613137
91T cell selection (GO:0045058)2.79315433
92protein neddylation (GO:0045116)2.79302989
93negative regulation of actin filament bundle assembly (GO:0032232)2.78129881
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76407035
95T cell costimulation (GO:0031295)2.74076319
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73972883
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73906833
98base-excision repair, AP site formation (GO:0006285)2.72920073
99mannosylation (GO:0097502)2.71498582
100regulation of viral genome replication (GO:0045069)2.71271577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.71949206
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.73228375
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53916959
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36412462
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34221670
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.32614961
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31488170
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.25432894
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08715632
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.85782790
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.79669384
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76192173
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52291420
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.51098743
15* MYB_26560356_Chip-Seq_TH2_Human2.48729478
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46266805
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.44046901
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19823176
19VDR_22108803_ChIP-Seq_LS180_Human2.19275487
20VDR_23849224_ChIP-Seq_CD4+_Human2.19040009
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10872209
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97321302
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.91508456
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89624790
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84907505
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83719125
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83582138
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76486414
29RUNX_20019798_ChIP-Seq_JUKART_Human1.74838309
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74365094
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.73378714
32FOXP3_21729870_ChIP-Seq_TREG_Human1.73318460
33GATA3_27048872_Chip-Seq_THYMUS_Human1.70830699
34* MYB_26560356_Chip-Seq_TH1_Human1.65915503
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62906039
36UTX_26944678_Chip-Seq_JUKART_Human1.59140196
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56483791
38GATA3_26560356_Chip-Seq_TH2_Human1.55468879
39HTT_18923047_ChIP-ChIP_STHdh_Human1.48480620
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47386922
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40723159
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36297779
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36124262
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34604477
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33133185
46ELK1_19687146_ChIP-ChIP_HELA_Human1.32224637
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31749893
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.31698108
49IGF1R_20145208_ChIP-Seq_DFB_Human1.31303422
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25896134
51ZNF274_21170338_ChIP-Seq_K562_Hela1.25169327
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24734664
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23721738
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23009706
55SPI1_23547873_ChIP-Seq_NB4_Human1.22319413
56BCL6_27268052_Chip-Seq_Bcells_Human1.21013718
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18881637
58* MAF_26560356_Chip-Seq_TH1_Human1.17444307
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16787840
60* MAF_26560356_Chip-Seq_TH2_Human1.16438714
61SCL_19346495_ChIP-Seq_HPC-7_Human1.16288151
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14223709
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12588226
64TAF2_19829295_ChIP-Seq_ESCs_Human1.12252402
65MYC_18940864_ChIP-ChIP_HL60_Human1.11909981
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09829432
67AR_20517297_ChIP-Seq_VCAP_Human1.09233673
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08732757
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08209834
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07827899
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.07671567
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07671567
73NANOG_20526341_ChIP-Seq_ESCs_Human1.05944366
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05678884
75TP53_22573176_ChIP-Seq_HFKS_Human1.02784297
76P300_27268052_Chip-Seq_Bcells_Human1.02058561
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01632842
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.00279691
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99323575
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98070184
81FLI1_27457419_Chip-Seq_LIVER_Mouse0.95959859
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94624972
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93838467
84* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90607147
85NCOR_22424771_ChIP-Seq_293T_Human0.90528341
86E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90471122
87CIITA_25753668_ChIP-Seq_RAJI_Human0.89803604
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.89620007
89CTCF_20526341_ChIP-Seq_ESCs_Human0.88984964
90ERG_20517297_ChIP-Seq_VCAP_Human0.88175267
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87900912
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87655666
93STAT1_20625510_ChIP-Seq_HELA_Human0.86681130
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.86522862
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85132160
96E2F7_22180533_ChIP-Seq_HELA_Human0.84638131
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81635507
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.81447963
99MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81295707
100* GATA3_21878914_ChIP-Seq_MCF-7_Human0.81185718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.75942728
2MP0009785_altered_susceptibility_to3.46907978
3MP0001835_abnormal_antigen_presentation3.25297579
4MP0003763_abnormal_thymus_physiology3.13267661
5MP0009333_abnormal_splenocyte_physiolog2.71488668
6MP0005000_abnormal_immune_tolerance2.57400104
7MP0002148_abnormal_hypersensitivity_rea2.48806557
8MP0005025_abnormal_response_to2.45466023
9MP0001800_abnormal_humoral_immune2.39498079
10MP0002420_abnormal_adaptive_immunity2.38258663
11MP0002166_altered_tumor_susceptibility2.37021809
12MP0009379_abnormal_foot_pigmentation2.30568372
13MP0001819_abnormal_immune_cell2.30378574
14MP0004147_increased_porphyrin_level2.29358232
15MP0002723_abnormal_immune_serum2.27614414
16MP0003866_abnormal_defecation2.05844951
17MP0006082_CNS_inflammation2.05388220
18MP0005084_abnormal_gallbladder_morpholo2.04581403
19MP0005645_abnormal_hypothalamus_physiol1.93517743
20MP0002398_abnormal_bone_marrow1.92489454
21MP0002452_abnormal_antigen_presenting1.89731233
22MP0005387_immune_system_phenotype1.88977376
23MP0001790_abnormal_immune_system1.88977376
24MP0002006_tumorigenesis1.88767961
25MP0000716_abnormal_immune_system1.88580335
26MP0000372_irregular_coat_pigmentation1.79072018
27MP0002102_abnormal_ear_morphology1.72549281
28MP0001873_stomach_inflammation1.71324430
29MP0002722_abnormal_immune_system1.70121283
30MP0002405_respiratory_system_inflammati1.68634233
31MP0000689_abnormal_spleen_morphology1.67113033
32MP0003806_abnormal_nucleotide_metabolis1.59352552
33MP0000685_abnormal_immune_system1.59202024
34MP0008872_abnormal_physiological_respon1.56947874
35MP0000703_abnormal_thymus_morphology1.52456066
36MP0002419_abnormal_innate_immunity1.51195874
37MP0002429_abnormal_blood_cell1.50574829
38MP0002933_joint_inflammation1.47561287
39MP0008058_abnormal_DNA_repair1.44827646
40MP0010155_abnormal_intestine_physiology1.43593907
41MP0003786_premature_aging1.43562850
42MP0001845_abnormal_inflammatory_respons1.41621197
43MP0005464_abnormal_platelet_physiology1.39830542
44MP0001905_abnormal_dopamine_level1.37421796
45MP0006072_abnormal_retinal_apoptosis1.36785940
46MP0009697_abnormal_copulation1.30252569
47MP0006036_abnormal_mitochondrial_physio1.26693474
48MP0005377_hearing/vestibular/ear_phenot1.26194893
49MP0003878_abnormal_ear_physiology1.26194893
50MP0000465_gastrointestinal_hemorrhage1.23696067
51MP0002138_abnormal_hepatobiliary_system1.21103778
52MP0003448_altered_tumor_morphology1.20873720
53MP0005075_abnormal_melanosome_morpholog1.17686114
54MP0008469_abnormal_protein_level1.14605836
55MP0003724_increased_susceptibility_to1.11768413
56MP0008875_abnormal_xenobiotic_pharmacok1.10542492
57MP0001853_heart_inflammation1.10097386
58MP0001919_abnormal_reproductive_system1.08826377
59MP0000858_altered_metastatic_potential1.08230183
60MP0002736_abnormal_nociception_after1.08049267
61MP0002019_abnormal_tumor_incidence1.06465979
62MP0001764_abnormal_homeostasis1.05016415
63MP0009763_increased_sensitivity_to1.03521830
64MP0010386_abnormal_urinary_bladder1.03282432
65MP0001968_abnormal_touch/_nociception1.02899489
66MP0003436_decreased_susceptibility_to1.02836610
67MP0005646_abnormal_pituitary_gland0.98561940
68MP0006292_abnormal_olfactory_placode0.97413542
69MP0002132_abnormal_respiratory_system0.95357672
70MP0002277_abnormal_respiratory_mucosa0.94007042
71MP0005085_abnormal_gallbladder_physiolo0.92339925
72MP0002693_abnormal_pancreas_physiology0.92110711
73MP0004145_abnormal_muscle_electrophysio0.92072486
74MP0005551_abnormal_eye_electrophysiolog0.91230189
75MP0005389_reproductive_system_phenotype0.90225851
76MP0003638_abnormal_response/metabolism_0.90128001
77MP0002837_dystrophic_cardiac_calcinosis0.89119606
78MP0009764_decreased_sensitivity_to0.85997638
79MP0003646_muscle_fatigue0.84438992
80MP0002163_abnormal_gland_morphology0.82548483
81MP0003075_altered_response_to0.82341075
82MP0001542_abnormal_bone_strength0.81158972
83MP0002876_abnormal_thyroid_physiology0.79480059
84MP0005083_abnormal_biliary_tract0.78656190
85MP0001485_abnormal_pinna_reflex0.77631449
86MP0005410_abnormal_fertilization0.77279736
87MP0008873_increased_physiological_sensi0.76398144
88MP0003252_abnormal_bile_duct0.74715380
89MP0003011_delayed_dark_adaptation0.74290889
90MP0002396_abnormal_hematopoietic_system0.74281077
91MP0005166_decreased_susceptibility_to0.74266504
92MP0003137_abnormal_impulse_conducting0.73895093
93MP0005636_abnormal_mineral_homeostasis0.71755558
94MP0004134_abnormal_chest_morphology0.70425628
95MP0001501_abnormal_sleep_pattern0.69807215
96MP0001119_abnormal_female_reproductive0.69099854
97MP0001533_abnormal_skeleton_physiology0.68196547
98MP0002928_abnormal_bile_duct0.66760712
99MP0010094_abnormal_chromosome_stability0.66659118
100MP0008995_early_reproductive_senescence0.64999859

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.09911284
2Abnormality of T cell number (HP:0011839)4.59861190
3T lymphocytopenia (HP:0005403)4.57292130
4Autoimmune hemolytic anemia (HP:0001890)4.55505247
5Abnormality of B cell number (HP:0010975)4.30550347
6Elevated erythrocyte sedimentation rate (HP:0003565)4.15874054
7Mitochondrial inheritance (HP:0001427)4.08798541
8Severe combined immunodeficiency (HP:0004430)4.02924878
9IgG deficiency (HP:0004315)3.97548384
10Increased IgM level (HP:0003496)3.83750303
11Acute necrotizing encephalopathy (HP:0006965)3.83087806
12Abnormal mitochondria in muscle tissue (HP:0008316)3.69805062
13Abnormality of the prostate (HP:0008775)3.67888780
14B lymphocytopenia (HP:0010976)3.59774402
15Hepatocellular necrosis (HP:0001404)3.49421565
16Hypoproteinemia (HP:0003075)3.47249406
17Abnormality of T cells (HP:0002843)3.38655611
18Increased intramyocellular lipid droplets (HP:0012240)3.38271889
19Increased CSF lactate (HP:0002490)3.29454793
20Combined immunodeficiency (HP:0005387)3.23218164
21Acute encephalopathy (HP:0006846)3.20847583
22Congenital stationary night blindness (HP:0007642)3.15087834
23Hepatic necrosis (HP:0002605)3.14509570
24Autoimmune thrombocytopenia (HP:0001973)3.09610516
25Progressive macrocephaly (HP:0004481)3.08536925
26Abnormality of eosinophils (HP:0001879)3.06868949
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05936201
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05936201
29Absent rod-and cone-mediated responses on ERG (HP:0007688)3.04935333
30Increased hepatocellular lipid droplets (HP:0006565)3.04757644
31Renal Fanconi syndrome (HP:0001994)3.04339963
32Thyroiditis (HP:0100646)3.03201056
33Pancytopenia (HP:0001876)2.97982873
34Agammaglobulinemia (HP:0004432)2.94172731
35Increased muscle lipid content (HP:0009058)2.90727464
363-Methylglutaconic aciduria (HP:0003535)2.88992333
37Eosinophilia (HP:0001880)2.84437219
38Lipid accumulation in hepatocytes (HP:0006561)2.82425955
39Cerebral edema (HP:0002181)2.81132822
40Encephalitis (HP:0002383)2.80342753
41Prostate neoplasm (HP:0100787)2.75055895
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.49908050
43Chronic diarrhea (HP:0002028)2.45571447
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44354363
45Leukocytosis (HP:0001974)2.44252604
46Meningitis (HP:0001287)2.43120604
47Stomatitis (HP:0010280)2.42942537
48Granulocytopenia (HP:0001913)2.41098637
49Abnormal rod and cone electroretinograms (HP:0008323)2.40226723
50Stomach cancer (HP:0012126)2.33256074
51Cerebral palsy (HP:0100021)2.29469569
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27701076
53Obstructive lung disease (HP:0006536)2.26871230
54Chronic obstructive pulmonary disease (HP:0006510)2.26871230
55Panhypogammaglobulinemia (HP:0003139)2.26718585
56IgM deficiency (HP:0002850)2.23278507
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22640617
58Lactic acidosis (HP:0003128)2.21763374
59Myositis (HP:0100614)2.20291700
60Optic disc pallor (HP:0000543)2.19506696
61Type I transferrin isoform profile (HP:0003642)2.14447679
62Increased serum lactate (HP:0002151)2.12851904
63Pancreatic cysts (HP:0001737)2.12535839
64Exertional dyspnea (HP:0002875)2.11923523
65Recurrent bronchitis (HP:0002837)2.11803820
66Severe visual impairment (HP:0001141)2.09567843
67Lymphopenia (HP:0001888)2.09527019
68Abnormality of male internal genitalia (HP:0000022)2.08784687
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.08750229
70Generalized aminoaciduria (HP:0002909)2.08441124
71Hypergammaglobulinemia (HP:0010702)2.08224167
72Abnormality of T cell physiology (HP:0011840)2.07607710
73Abnormality of macrophages (HP:0004311)2.06643011
74Dicarboxylic aciduria (HP:0003215)2.06588034
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06588034
76Respiratory failure (HP:0002878)2.04900596
77Exercise intolerance (HP:0003546)2.01155239
78Amyotrophic lateral sclerosis (HP:0007354)1.99431361
79Recurrent viral infections (HP:0004429)1.99272962
80Congenital, generalized hypertrichosis (HP:0004540)1.97503167
81Lethargy (HP:0001254)1.95635437
82Acute hepatic failure (HP:0006554)1.95047025
83Decreased central vision (HP:0007663)1.92868965
84Attenuation of retinal blood vessels (HP:0007843)1.89932870
85Oral leukoplakia (HP:0002745)1.88010953
86Methylmalonic aciduria (HP:0012120)1.87507723
87Lymphoma (HP:0002665)1.86200318
88Methylmalonic acidemia (HP:0002912)1.84928952
89Hypoplasia of the thymus (HP:0000778)1.83028891
90Pancreatic fibrosis (HP:0100732)1.80720918
91Neutropenia (HP:0001875)1.76876704
92Recurrent fungal infections (HP:0002841)1.76552651
93Abolished electroretinogram (ERG) (HP:0000550)1.75400203
94Joint swelling (HP:0001386)1.75300779
95Recurrent cutaneous fungal infections (HP:0011370)1.74874447
96Chronic mucocutaneous candidiasis (HP:0002728)1.74874447
97Constricted visual fields (HP:0001133)1.74165588
98Abnormal number of erythroid precursors (HP:0012131)1.73947110
99Absent thumb (HP:0009777)1.73630877
100Gangrene (HP:0100758)1.72995565

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.89818388
2KDR5.86796380
3TXK4.28564761
4VRK23.54844306
5BCKDK3.52651021
6MAP4K12.36681514
7MAP3K122.31536718
8VRK12.25601683
9ZAK2.23410986
10TESK12.19559748
11SCYL22.15473385
12BUB12.01489422
13ITK1.94259508
14ADRBK21.92671521
15MAP4K21.83463484
16LIMK11.82154510
17TAOK31.82058427
18MAP3K111.72212401
19GRK11.64713446
20NUAK11.56775634
21TEC1.53591493
22SYK1.40322667
23TIE11.37256046
24TLK11.36981513
25FES1.36271385
26GRK61.34428387
27GRK71.27629037
28MAPKAPK31.27467657
29PASK1.26233421
30MAPK151.22253633
31PRKCQ1.20242089
32DAPK11.18518563
33PINK11.15306860
34MUSK1.14867681
35BTK1.11045616
36CDK191.00768990
37MYLK0.98240111
38LCK0.97554246
39STK160.97323835
40KIT0.94722150
41MST40.93891031
42IKBKE0.86027569
43NME10.80719122
44LYN0.77934145
45RPS6KA50.76977891
46PIK3CA0.75735826
47TBK10.74432321
48CSK0.74000891
49ZAP700.72303310
50NME20.72251988
51TNK20.71435731
52CSF1R0.69831980
53IKBKB0.68367547
54TSSK60.67521076
55PIM10.67469074
56BMPR20.62124963
57INSRR0.60676746
58EIF2AK30.54942653
59AURKA0.52921013
60MAP3K50.51312078
61PIM20.51127795
62MATK0.48998423
63OXSR10.47275537
64PIK3CG0.46737994
65ADRBK10.44440920
66JAK30.41485938
67CSNK1G30.39998214
68IGF1R0.39872458
69MAP2K70.38146572
70FYN0.37050021
71OBSCN0.36829223
72CDK80.36727438
73STK390.34926926
74ROCK10.34367935
75PRKCA0.33760902
76WEE10.33728417
77CAMKK20.32541717
78CSNK2A10.32020029
79RPS6KA40.31983667
80WNK40.31628260
81RIPK40.30405468
82CSNK2A20.29553635
83DAPK30.29323463
84MAP2K60.28557270
85AURKB0.27010747
86BMPR1B0.26605962
87CDC70.25521036
88PAK10.25161242
89DYRK20.24947268
90GRK50.24821236
91MAPKAPK50.24667967
92TAOK20.23577803
93PRKACA0.23508966
94PRKCD0.23448246
95PLK40.22623000
96CSNK1G10.22269755
97ILK0.22017621
98CAMKK10.21793660
99ABL20.21640289
100MAPK130.21006576

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.19946255
2Proteasome_Homo sapiens_hsa030504.69332902
3Oxidative phosphorylation_Homo sapiens_hsa001903.69109734
4Parkinsons disease_Homo sapiens_hsa050123.17870999
5Ribosome_Homo sapiens_hsa030102.85932115
6Antigen processing and presentation_Homo sapiens_hsa046122.74403619
7Graft-versus-host disease_Homo sapiens_hsa053322.66673312
8Autoimmune thyroid disease_Homo sapiens_hsa053202.47367042
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44748103
10Hematopoietic cell lineage_Homo sapiens_hsa046402.37073566
11Allograft rejection_Homo sapiens_hsa053302.34580611
12RNA polymerase_Homo sapiens_hsa030202.21676974
13Alzheimers disease_Homo sapiens_hsa050102.08563918
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92930325
15Type I diabetes mellitus_Homo sapiens_hsa049401.91704854
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87339845
17Huntingtons disease_Homo sapiens_hsa050161.82308982
18DNA replication_Homo sapiens_hsa030301.67186596
19T cell receptor signaling pathway_Homo sapiens_hsa046601.63010111
20Rheumatoid arthritis_Homo sapiens_hsa053231.51798591
21Cardiac muscle contraction_Homo sapiens_hsa042601.49553808
22Protein export_Homo sapiens_hsa030601.49171740
23Phototransduction_Homo sapiens_hsa047441.47689869
24Pyrimidine metabolism_Homo sapiens_hsa002401.40031977
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.34765024
26Homologous recombination_Homo sapiens_hsa034401.33858575
27Nitrogen metabolism_Homo sapiens_hsa009101.25719736
28Mismatch repair_Homo sapiens_hsa034301.20639797
29Base excision repair_Homo sapiens_hsa034101.15926223
30Asthma_Homo sapiens_hsa053101.11161041
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09317931
32Systemic lupus erythematosus_Homo sapiens_hsa053221.03759425
33Fanconi anemia pathway_Homo sapiens_hsa034601.03389409
34Malaria_Homo sapiens_hsa051441.00081873
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99720115
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98880087
37Measles_Homo sapiens_hsa051620.98608948
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.97144397
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96637458
40Viral myocarditis_Homo sapiens_hsa054160.95668016
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95255378
42Salmonella infection_Homo sapiens_hsa051320.94107960
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93601520
44Purine metabolism_Homo sapiens_hsa002300.89079099
45Shigellosis_Homo sapiens_hsa051310.87013138
46RNA degradation_Homo sapiens_hsa030180.86368685
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82736387
48Caffeine metabolism_Homo sapiens_hsa002320.82625279
49Peroxisome_Homo sapiens_hsa041460.80451642
50Nucleotide excision repair_Homo sapiens_hsa034200.79868911
51One carbon pool by folate_Homo sapiens_hsa006700.77036380
52Spliceosome_Homo sapiens_hsa030400.76454333
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74831003
54Chemical carcinogenesis_Homo sapiens_hsa052040.71524976
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.69044527
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68581148
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68419885
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67209860
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.66347598
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66164632
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66076588
62Propanoate metabolism_Homo sapiens_hsa006400.63785189
63Retinol metabolism_Homo sapiens_hsa008300.61740372
64Olfactory transduction_Homo sapiens_hsa047400.60466465
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58842607
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54007566
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53999152
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.53785095
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.53518323
70Fatty acid elongation_Homo sapiens_hsa000620.51659442
71Linoleic acid metabolism_Homo sapiens_hsa005910.50992392
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50854274
73Herpes simplex infection_Homo sapiens_hsa051680.49524957
74African trypanosomiasis_Homo sapiens_hsa051430.49479623
75Metabolic pathways_Homo sapiens_hsa011000.46586747
76Butanoate metabolism_Homo sapiens_hsa006500.43982473
77Glutathione metabolism_Homo sapiens_hsa004800.41146873
78Epstein-Barr virus infection_Homo sapiens_hsa051690.39201977
79Tryptophan metabolism_Homo sapiens_hsa003800.35637769
80Staphylococcus aureus infection_Homo sapiens_hsa051500.35250049
81N-Glycan biosynthesis_Homo sapiens_hsa005100.34584494
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33897793
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32236199
84Arachidonic acid metabolism_Homo sapiens_hsa005900.31065071
85Folate biosynthesis_Homo sapiens_hsa007900.29459885
86Leishmaniasis_Homo sapiens_hsa051400.28268114
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28200127
88Legionellosis_Homo sapiens_hsa051340.27216375
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24659737
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24374781
91RNA transport_Homo sapiens_hsa030130.24018834
92HTLV-I infection_Homo sapiens_hsa051660.23672963
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23552287
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23122188
95Alcoholism_Homo sapiens_hsa050340.22890931
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20660078
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20564926
98Pyruvate metabolism_Homo sapiens_hsa006200.19451225
99Taste transduction_Homo sapiens_hsa047420.19376709
100Salivary secretion_Homo sapiens_hsa049700.18977557

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