PPIAL4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.22608667
2ATP synthesis coupled proton transport (GO:0015986)5.94723567
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.94723567
4DNA deamination (GO:0045006)5.43179373
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.59051751
6cytidine metabolic process (GO:0046087)4.47398304
7cytidine catabolic process (GO:0006216)4.47398304
8cytidine deamination (GO:0009972)4.47398304
9respiratory electron transport chain (GO:0022904)4.46929820
10electron transport chain (GO:0022900)4.41743640
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.23758286
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.12375816
13proteasome assembly (GO:0043248)4.06090106
14positive regulation of protein homodimerization activity (GO:0090073)4.01644282
15regulation of cellular amino acid metabolic process (GO:0006521)3.95524008
16chaperone-mediated protein transport (GO:0072321)3.84140676
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79232119
18actin nucleation (GO:0045010)3.78493713
19protein complex biogenesis (GO:0070271)3.76320990
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.75728393
21positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.71437879
22preassembly of GPI anchor in ER membrane (GO:0016254)3.70784985
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.65847030
24negative regulation of calcium ion transport into cytosol (GO:0010523)3.64808808
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.61851575
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.61851575
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.61851575
28protein neddylation (GO:0045116)3.59677054
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58611746
30protein-cofactor linkage (GO:0018065)3.55148453
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.53884168
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.53884168
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.52567806
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.51884033
35ATP biosynthetic process (GO:0006754)3.46643134
36regulation of chronic inflammatory response (GO:0002676)3.44677817
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.43377572
38signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43377572
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.41548821
40negative regulation of ligase activity (GO:0051352)3.40989041
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40989041
42mitochondrial respiratory chain complex assembly (GO:0033108)3.38626517
43antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.35928313
44hydrogen ion transmembrane transport (GO:1902600)3.33358957
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32770292
46sequestering of actin monomers (GO:0042989)3.30569567
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27375672
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27375672
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25084894
50regulation of B cell receptor signaling pathway (GO:0050855)3.24757046
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23943820
52cellular response to interleukin-15 (GO:0071350)3.23602461
53platelet dense granule organization (GO:0060155)3.22775721
54GPI anchor biosynthetic process (GO:0006506)3.20136550
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.19785814
56NADH dehydrogenase complex assembly (GO:0010257)3.19785814
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19785814
58protein maturation by protein folding (GO:0022417)3.19536789
59proton transport (GO:0015992)3.18954342
60iron-sulfur cluster assembly (GO:0016226)3.17506077
61metallo-sulfur cluster assembly (GO:0031163)3.17506077
62hydrogen transport (GO:0006818)3.12089431
63ubiquinone biosynthetic process (GO:0006744)3.08498845
64cytochrome complex assembly (GO:0017004)3.06694657
65anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05807334
66negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.05255824
67protein deneddylation (GO:0000338)3.02222482
68transcription elongation from RNA polymerase III promoter (GO:0006385)3.02006757
69termination of RNA polymerase III transcription (GO:0006386)3.02006757
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01193559
71negative regulation of mast cell activation (GO:0033004)3.00654317
72base-excision repair, AP site formation (GO:0006285)2.99852314
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97431164
74respiratory chain complex IV assembly (GO:0008535)2.96683294
75ubiquinone metabolic process (GO:0006743)2.95645537
76GPI anchor metabolic process (GO:0006505)2.94656742
77pseudouridine synthesis (GO:0001522)2.93560177
78negative regulation of heart rate (GO:0010459)2.91190234
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88670034
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85299319
81positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85122695
82response to pheromone (GO:0019236)2.82325492
83positive regulation of ligase activity (GO:0051351)2.81736561
84cullin deneddylation (GO:0010388)2.81082615
85ribosomal small subunit assembly (GO:0000028)2.80411680
86maturation of SSU-rRNA (GO:0030490)2.78231491
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.76752546
88mannosylation (GO:0097502)2.76094277
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74433224
90regulation of cellular amine metabolic process (GO:0033238)2.74087210
91regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.68913364
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67547265
93response to interleukin-15 (GO:0070672)2.66842175
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63847943
95regulation of interleukin-8 secretion (GO:2000482)2.63806443
96positive regulation of cell cycle arrest (GO:0071158)2.63610482
97positive regulation of defense response to virus by host (GO:0002230)2.62483967
98regulation of cellular respiration (GO:0043457)2.60763844
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.59258442
100regulation of hypersensitivity (GO:0002883)2.58928577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.58458315
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.98504409
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94533033
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.92735774
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72319971
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.71696789
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.56670083
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20270421
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98216155
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87389878
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69887401
12VDR_23849224_ChIP-Seq_CD4+_Human2.60427262
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.60206792
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.56790402
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49763633
16ZNF274_21170338_ChIP-Seq_K562_Hela2.22680779
17VDR_22108803_ChIP-Seq_LS180_Human2.19441617
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13500297
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.10677997
20ELK1_19687146_ChIP-ChIP_HELA_Human2.10242070
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09806978
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.09104337
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98156773
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.95754740
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90680068
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89542560
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74228512
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.73513610
29FOXP3_21729870_ChIP-Seq_TREG_Human1.73235876
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63965974
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55053437
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54456298
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.51355160
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47460033
35* GATA3_26560356_Chip-Seq_TH2_Human1.47385671
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46554864
37* MYB_26560356_Chip-Seq_TH2_Human1.46284051
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45404704
39IGF1R_20145208_ChIP-Seq_DFB_Human1.43389992
40TP53_22573176_ChIP-Seq_HFKS_Human1.39857500
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38568397
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36512766
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32982048
44DCP1A_22483619_ChIP-Seq_HELA_Human1.32777879
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32448471
46CIITA_25753668_ChIP-Seq_RAJI_Human1.28771040
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28567789
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27048465
49MYC_18940864_ChIP-ChIP_HL60_Human1.26237186
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23500881
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21606144
52GABP_19822575_ChIP-Seq_HepG2_Human1.21362212
53AR_20517297_ChIP-Seq_VCAP_Human1.19325280
54SOX2_19829295_ChIP-Seq_ESCs_Human1.18046820
55NANOG_19829295_ChIP-Seq_ESCs_Human1.18046820
56NCOR_22424771_ChIP-Seq_293T_Human1.15614308
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.14532738
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11545035
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10837947
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10126200
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09281057
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09159231
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08740108
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07339397
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07255572
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.05997776
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05659350
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05238554
69GATA3_27048872_Chip-Seq_THYMUS_Human1.03685148
70STAT1_20625510_ChIP-Seq_HELA_Human1.03474702
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03187845
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02574820
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02223127
74ERG_20517297_ChIP-Seq_VCAP_Human1.01844893
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.01760233
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01760233
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01493782
78* TAF15_26573619_Chip-Seq_HEK293_Human1.01393474
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.00609449
80HTT_18923047_ChIP-ChIP_STHdh_Human0.99651591
81E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99368226
82EWS_26573619_Chip-Seq_HEK293_Human0.99329568
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98811902
84ER_23166858_ChIP-Seq_MCF-7_Human0.98697370
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98605067
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98383858
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98105566
88PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97980419
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97096539
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96970460
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.95340246
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93513585
93P300_19829295_ChIP-Seq_ESCs_Human0.93258868
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92896617
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92737684
96TTF2_22483619_ChIP-Seq_HELA_Human0.92660902
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.92030801
98TAF2_19829295_ChIP-Seq_ESCs_Human0.91036348
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90768187
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90596278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.52356189
2MP0009785_altered_susceptibility_to2.94075958
3MP0005645_abnormal_hypothalamus_physiol2.82429481
4MP0004147_increased_porphyrin_level2.79743633
5MP0001835_abnormal_antigen_presentation2.73723531
6MP0005360_urolithiasis2.62460657
7MP0000685_abnormal_immune_system2.37352635
8MP0009333_abnormal_splenocyte_physiolog2.31305144
9MP0003763_abnormal_thymus_physiology2.27772003
10MP0001800_abnormal_humoral_immune2.26719830
11MP0003724_increased_susceptibility_to2.25653556
12MP0003646_muscle_fatigue2.12371584
13MP0006072_abnormal_retinal_apoptosis2.07906379
14MP0008872_abnormal_physiological_respon1.98195318
15MP0002148_abnormal_hypersensitivity_rea1.97028832
16MP0002102_abnormal_ear_morphology1.90345804
17MP0003011_delayed_dark_adaptation1.88982368
18MP0005000_abnormal_immune_tolerance1.84302024
19MP0005084_abnormal_gallbladder_morpholo1.76087937
20MP0002723_abnormal_immune_serum1.74945138
21MP0002736_abnormal_nociception_after1.73050454
22MP0003866_abnormal_defecation1.71967533
23MP0005646_abnormal_pituitary_gland1.71274694
24MP0005387_immune_system_phenotype1.70439857
25MP0001790_abnormal_immune_system1.70439857
26MP0002452_abnormal_antigen_presenting1.65151010
27MP0002420_abnormal_adaptive_immunity1.64188150
28MP0005253_abnormal_eye_physiology1.63890496
29MP0002876_abnormal_thyroid_physiology1.63433651
30MP0001819_abnormal_immune_cell1.62871886
31MP0003786_premature_aging1.60425943
32MP0008875_abnormal_xenobiotic_pharmacok1.60098851
33MP0009764_decreased_sensitivity_to1.58893045
34MP0005075_abnormal_melanosome_morpholog1.54695319
35MP0005551_abnormal_eye_electrophysiolog1.52316027
36MP0001905_abnormal_dopamine_level1.46749320
37MP0005025_abnormal_response_to1.42584620
38MP0008877_abnormal_DNA_methylation1.39428732
39MP0001986_abnormal_taste_sensitivity1.39309170
40MP0002166_altered_tumor_susceptibility1.39283034
41MP0001501_abnormal_sleep_pattern1.38663837
42MP0004142_abnormal_muscle_tone1.35745929
43MP0001873_stomach_inflammation1.32664600
44MP0010155_abnormal_intestine_physiology1.32310540
45MP0001968_abnormal_touch/_nociception1.29504693
46MP0006082_CNS_inflammation1.27802895
47MP0002006_tumorigenesis1.25738994
48MP0002638_abnormal_pupillary_reflex1.23802009
49MP0001845_abnormal_inflammatory_respons1.22739191
50MP0006036_abnormal_mitochondrial_physio1.19847744
51MP0003252_abnormal_bile_duct1.19833260
52MP0008995_early_reproductive_senescence1.17962815
53MP0005085_abnormal_gallbladder_physiolo1.17597253
54MP0006292_abnormal_olfactory_placode1.17483185
55MP0000716_abnormal_immune_system1.16273286
56MP0000689_abnormal_spleen_morphology1.13546429
57MP0005377_hearing/vestibular/ear_phenot1.13428067
58MP0003878_abnormal_ear_physiology1.13428067
59MP0002398_abnormal_bone_marrow1.13357818
60MP0002138_abnormal_hepatobiliary_system1.09973234
61MP0000372_irregular_coat_pigmentation1.09647420
62MP0002277_abnormal_respiratory_mucosa1.08183843
63MP0003718_maternal_effect1.07101106
64MP0003436_decreased_susceptibility_to1.06777958
65MP0001984_abnormal_olfaction1.06303088
66MP0004145_abnormal_muscle_electrophysio1.03759525
67MP0002419_abnormal_innate_immunity1.01857158
68MP0003638_abnormal_response/metabolism_0.99730412
69MP0002405_respiratory_system_inflammati0.99166129
70MP0003806_abnormal_nucleotide_metabolis0.97280954
71MP0001764_abnormal_homeostasis0.94481023
72MP0008058_abnormal_DNA_repair0.94216663
73MP0008789_abnormal_olfactory_epithelium0.92279437
74MP0005636_abnormal_mineral_homeostasis0.91327007
75MP0002722_abnormal_immune_system0.91218978
76MP0002429_abnormal_blood_cell0.91148995
77MP0005410_abnormal_fertilization0.90247005
78MP0008469_abnormal_protein_level0.89834539
79MP0005167_abnormal_blood-brain_barrier0.87462615
80MP0000230_abnormal_systemic_arterial0.87256516
81MP0009763_increased_sensitivity_to0.87147349
82MP0001533_abnormal_skeleton_physiology0.85161136
83MP0002272_abnormal_nervous_system0.82074277
84MP0004885_abnormal_endolymph0.80693082
85MP0001919_abnormal_reproductive_system0.79536163
86MP0002163_abnormal_gland_morphology0.78561130
87MP0006276_abnormal_autonomic_nervous0.78388200
88MP0005332_abnormal_amino_acid0.78044910
89MP0009046_muscle_twitch0.75885816
90MP0005367_renal/urinary_system_phenotyp0.75862641
91MP0000516_abnormal_urinary_system0.75862641
92MP0001853_heart_inflammation0.75155985
93MP0004215_abnormal_myocardial_fiber0.74510487
94MP0005365_abnormal_bile_salt0.73909734
95MP0003137_abnormal_impulse_conducting0.72248127
96MP0003075_altered_response_to0.72055983
97MP0002837_dystrophic_cardiac_calcinosis0.71601524
98MP0001765_abnormal_ion_homeostasis0.71209718
99MP0000703_abnormal_thymus_morphology0.70896851
100MP0004043_abnormal_pH_regulation0.69239639

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.38151440
2Acute necrotizing encephalopathy (HP:0006965)4.23118828
3Increased CSF lactate (HP:0002490)4.15110152
4IgG deficiency (HP:0004315)3.94705473
5Hepatocellular necrosis (HP:0001404)3.80354736
6Lipid accumulation in hepatocytes (HP:0006561)3.79836083
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.78118248
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.78118248
9Abnormal mitochondria in muscle tissue (HP:0008316)3.77828328
10Increased hepatocellular lipid droplets (HP:0006565)3.72307176
11Hepatic necrosis (HP:0002605)3.57275872
12Acute encephalopathy (HP:0006846)3.50318281
13Hypoproteinemia (HP:0003075)3.49587787
14Elevated erythrocyte sedimentation rate (HP:0003565)3.43661826
15Renal Fanconi syndrome (HP:0001994)3.43329073
16Progressive macrocephaly (HP:0004481)3.38237190
17Aplastic anemia (HP:0001915)3.34126949
18Increased intramyocellular lipid droplets (HP:0012240)3.20095733
19Congenital stationary night blindness (HP:0007642)3.16369846
20Stomatitis (HP:0010280)3.09799631
21T lymphocytopenia (HP:0005403)3.02065940
22Increased serum lactate (HP:0002151)2.99978570
23Abnormality of T cell number (HP:0011839)2.98402379
24Abnormality of B cell number (HP:0010975)2.94259940
25Abolished electroretinogram (ERG) (HP:0000550)2.89864340
26Cerebral edema (HP:0002181)2.89554149
27Increased muscle lipid content (HP:0009058)2.88761417
28Congenital, generalized hypertrichosis (HP:0004540)2.84723906
29Type II lissencephaly (HP:0007260)2.77194108
30Renal cortical cysts (HP:0000803)2.71592697
31Pancreatic cysts (HP:0001737)2.71451533
32B lymphocytopenia (HP:0010976)2.64764872
33Autoimmune hemolytic anemia (HP:0001890)2.62195487
34Exertional dyspnea (HP:0002875)2.59241562
35Severe combined immunodeficiency (HP:0004430)2.59066527
36Lactic acidosis (HP:0003128)2.56135598
37Abnormality of the prostate (HP:0008775)2.54901767
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52676432
39Generalized aminoaciduria (HP:0002909)2.47784649
40Abnormality of midbrain morphology (HP:0002418)2.43536220
41Molar tooth sign on MRI (HP:0002419)2.43536220
42Neonatal respiratory distress (HP:0002643)2.41475089
43Optic disc pallor (HP:0000543)2.39608388
44Respiratory failure (HP:0002878)2.34379972
45Abnormality of the renal cortex (HP:0011035)2.31414258
46Retrobulbar optic neuritis (HP:0100654)2.30482217
47Optic neuritis (HP:0100653)2.30482217
48CNS demyelination (HP:0007305)2.29079654
49Increased IgM level (HP:0003496)2.27622231
503-Methylglutaconic aciduria (HP:0003535)2.22527872
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22112017
52Lethargy (HP:0001254)2.21606943
53Exercise intolerance (HP:0003546)2.18915108
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18375079
55Abnormality of T cells (HP:0002843)2.17856418
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17154666
57Retinal dysplasia (HP:0007973)2.10613791
58Abnormality of urine glucose concentration (HP:0011016)2.07250940
59Glycosuria (HP:0003076)2.07250940
60Pancreatic fibrosis (HP:0100732)2.05656900
61Azoospermia (HP:0000027)2.04574597
62Nephronophthisis (HP:0000090)2.04069860
63Myositis (HP:0100614)2.03701590
64Pancytopenia (HP:0001876)1.96007172
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95114974
66Constricted visual fields (HP:0001133)1.94389595
67Pendular nystagmus (HP:0012043)1.92243017
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91881461
69Combined immunodeficiency (HP:0005387)1.91784994
70Abnormality of renal resorption (HP:0011038)1.91391547
71Oral leukoplakia (HP:0002745)1.90763074
72Abnormal spermatogenesis (HP:0008669)1.90673964
73Abnormal rod and cone electroretinograms (HP:0008323)1.87778098
74Thyroiditis (HP:0100646)1.87585864
75Keratoconus (HP:0000563)1.87507947
76Increased corneal curvature (HP:0100692)1.87507947
77Gangrene (HP:0100758)1.86754285
78Leukodystrophy (HP:0002415)1.86565489
79Pulmonary infiltrates (HP:0002113)1.86084609
80Chronic diarrhea (HP:0002028)1.85749730
81Orchitis (HP:0100796)1.81595479
82Abnormality of the renal medulla (HP:0100957)1.81301363
83Prostate neoplasm (HP:0100787)1.81155711
84Brittle hair (HP:0002299)1.80619591
85Stomach cancer (HP:0012126)1.79789155
86True hermaphroditism (HP:0010459)1.79188283
87Type I transferrin isoform profile (HP:0003642)1.78031789
88Abnormal albumin level (HP:0012116)1.77949413
89Hypoalbuminemia (HP:0003073)1.77949413
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76115907
91Sclerocornea (HP:0000647)1.74966318
92Abnormality of eosinophils (HP:0001879)1.73461218
93Abnormality of the pleura (HP:0002103)1.73142326
94Aplasia/hypoplasia of the uterus (HP:0008684)1.72929513
95Reduced antithrombin III activity (HP:0001976)1.72666264
96Progressive microcephaly (HP:0000253)1.71678121
97Attenuation of retinal blood vessels (HP:0007843)1.70131339
98Hypothermia (HP:0002045)1.68841499
99Increased serum pyruvate (HP:0003542)1.68404638
100Pancreatitis (HP:0001733)1.67841025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.32970343
2TAOK33.51590012
3ZAK3.44422019
4MAP3K123.12511835
5KDR2.97897397
6SCYL22.93117760
7GRK12.84582433
8VRK22.73894011
9TLK12.40377338
10TESK12.20433046
11STK162.18432425
12ADRBK21.96085828
13MST41.95146520
14BUB11.91264763
15TESK21.83567376
16BMPR21.73192433
17MUSK1.66758268
18ITK1.65089964
19MAP4K21.60169711
20NME11.53636327
21MAPKAPK31.52308681
22MYLK1.49570174
23DAPK11.41382583
24BCKDK1.41131504
25VRK11.38004776
26CDK81.37922977
27TIE11.36787178
28TEC1.34309236
29ERBB31.33069139
30NUAK11.27140846
31LIMK11.25722466
32SRPK11.23906814
33TRIM281.18562450
34SYK1.14309516
35WNK41.09722213
36MAP4K11.06080930
37BMPR1B1.05503542
38BTK1.03920387
39IKBKB1.03098701
40CCNB11.00889943
41MAP2K60.96825407
42TSSK60.96324107
43IKBKE0.94843343
44MAP2K70.88871556
45GRK60.87987737
46WNK30.87326172
47NEK10.81444328
48PHKG20.80517702
49PHKG10.80517702
50CSNK1G30.79887576
51MAP3K140.78781930
52INSRR0.78056337
53MAPK130.77307027
54OXSR10.76997014
55PDK20.75759374
56FRK0.74677158
57EIF2AK30.74322243
58TBK10.71156381
59PLK30.70833363
60DAPK20.66728880
61PLK40.65164686
62GRK70.64971937
63JAK30.64820751
64LYN0.64515281
65EIF2AK20.63731477
66TRPM70.63616617
67CSNK1G10.56116774
68FES0.55183661
69CSNK1A1L0.55104767
70PRKCQ0.52038126
71IGF1R0.51964691
72DAPK30.49758806
73ADRBK10.48946056
74RPS6KA50.47277041
75DYRK20.46937143
76LCK0.45443757
77GRK50.44745832
78CSNK1G20.43557117
79CAMK2A0.42914799
80PRKCA0.41178832
81CSK0.39278863
82AURKB0.39066312
83OBSCN0.38876522
84PIM20.38696004
85CSNK2A10.38476917
86FLT30.37726433
87ILK0.37086052
88PAK40.36624036
89PRKACA0.36371176
90ATR0.36208078
91MAP3K40.35031207
92MAPKAPK50.34878745
93TGFBR10.34597055
94PBK0.34189936
95CHEK20.32851893
96KIT0.32020469
97PASK0.31491738
98CDK190.30871474
99ROCK10.29584842
100CSNK2A20.28856556

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.83531808
2Oxidative phosphorylation_Homo sapiens_hsa001903.93900437
3Parkinsons disease_Homo sapiens_hsa050123.35978062
4Primary immunodeficiency_Homo sapiens_hsa053402.70954411
5Asthma_Homo sapiens_hsa053102.64881445
6Allograft rejection_Homo sapiens_hsa053302.44971592
7Autoimmune thyroid disease_Homo sapiens_hsa053202.40714080
8Protein export_Homo sapiens_hsa030602.34359657
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34239778
10Ribosome_Homo sapiens_hsa030102.23041918
11Graft-versus-host disease_Homo sapiens_hsa053322.17566808
12RNA polymerase_Homo sapiens_hsa030202.15254507
13Type I diabetes mellitus_Homo sapiens_hsa049402.14506696
14Alzheimers disease_Homo sapiens_hsa050102.13534081
15Huntingtons disease_Homo sapiens_hsa050162.08641427
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.08136372
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99465166
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82559404
19Homologous recombination_Homo sapiens_hsa034401.81067230
20One carbon pool by folate_Homo sapiens_hsa006701.61933952
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58381064
22Cardiac muscle contraction_Homo sapiens_hsa042601.58194652
23Antigen processing and presentation_Homo sapiens_hsa046121.45613527
24Rheumatoid arthritis_Homo sapiens_hsa053231.38599414
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37738190
26Mismatch repair_Homo sapiens_hsa034301.36349221
27Hematopoietic cell lineage_Homo sapiens_hsa046401.29818138
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27207165
29Phototransduction_Homo sapiens_hsa047441.12195466
30Pyrimidine metabolism_Homo sapiens_hsa002401.10144079
31Tryptophan metabolism_Homo sapiens_hsa003801.10083737
32Nitrogen metabolism_Homo sapiens_hsa009101.04146474
33Linoleic acid metabolism_Homo sapiens_hsa005910.99390168
34Systemic lupus erythematosus_Homo sapiens_hsa053220.98225642
35Base excision repair_Homo sapiens_hsa034100.95080936
36Viral myocarditis_Homo sapiens_hsa054160.94501786
37Basal transcription factors_Homo sapiens_hsa030220.92833065
38Nucleotide excision repair_Homo sapiens_hsa034200.92478265
39RNA degradation_Homo sapiens_hsa030180.91437840
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91276092
41DNA replication_Homo sapiens_hsa030300.90965026
42Propanoate metabolism_Homo sapiens_hsa006400.88991687
43Purine metabolism_Homo sapiens_hsa002300.88558383
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86374659
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.86046292
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85763735
47Peroxisome_Homo sapiens_hsa041460.84190501
48Selenocompound metabolism_Homo sapiens_hsa004500.81904394
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81607782
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81500292
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80008500
52Butanoate metabolism_Homo sapiens_hsa006500.79425057
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78789811
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78290734
55Spliceosome_Homo sapiens_hsa030400.76731237
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.75840206
57Ether lipid metabolism_Homo sapiens_hsa005650.75284453
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73148603
59Fanconi anemia pathway_Homo sapiens_hsa034600.72917570
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68268866
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65677018
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.65256358
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64452640
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64352365
65beta-Alanine metabolism_Homo sapiens_hsa004100.63501351
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61092673
67RNA transport_Homo sapiens_hsa030130.60414824
68Metabolic pathways_Homo sapiens_hsa011000.59741431
69Regulation of autophagy_Homo sapiens_hsa041400.57318387
70T cell receptor signaling pathway_Homo sapiens_hsa046600.56744488
71Collecting duct acid secretion_Homo sapiens_hsa049660.55309707
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50919405
73Caffeine metabolism_Homo sapiens_hsa002320.49416360
74Fat digestion and absorption_Homo sapiens_hsa049750.48642312
75Fatty acid elongation_Homo sapiens_hsa000620.46379158
76Pyruvate metabolism_Homo sapiens_hsa006200.46062207
77Olfactory transduction_Homo sapiens_hsa047400.44364087
78Chemical carcinogenesis_Homo sapiens_hsa052040.41730864
79Arachidonic acid metabolism_Homo sapiens_hsa005900.39531865
80Staphylococcus aureus infection_Homo sapiens_hsa051500.38760157
81Herpes simplex infection_Homo sapiens_hsa051680.37046573
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36506793
83Retinol metabolism_Homo sapiens_hsa008300.36197842
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35907446
85Epstein-Barr virus infection_Homo sapiens_hsa051690.35792928
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34777766
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33027411
88Non-homologous end-joining_Homo sapiens_hsa034500.32747186
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31975727
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31923120
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31589614
92Measles_Homo sapiens_hsa051620.30054596
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29750274
94Sulfur metabolism_Homo sapiens_hsa009200.29540914
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.28842449
96Vitamin digestion and absorption_Homo sapiens_hsa049770.28769688
97Taste transduction_Homo sapiens_hsa047420.28291300
98Leishmaniasis_Homo sapiens_hsa051400.27764668
99Salmonella infection_Homo sapiens_hsa051320.26893799
100Nicotine addiction_Homo sapiens_hsa050330.25427249

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